The human immune system is critical for protection against infections and cancer, but diseases of the immune system can be devastating. These include allergic responses, immunodeficiencies and immune reactions directed against self, called autoimmunity. Autoimmune diseases afflict at least one in twelve Americans and are a leading cause of disability and early death in young women of child-bearing age. Our mission is to improve the lives of patients through a continuum of basic mechanistic studies, clinical research, industry collaborations and clinical care.

Scientists in Arthritis and Clinical Immunology focus on understanding systemic autoimmunity and deciphering basic immunologic concepts. Our studies address the etiology, pathogenesis and molecular mechanisms of complex human autoimmune diseases, such as systemic lupus erythematosus, Sjögren’s syndrome, rheumatoid arthritis, inflammatory myositis, multiple sclerosis (MS) and thrombotic thrombocytopenic purpura. Our studies on immune development and mechanisms of immune protection or perturbation have broad impact on immune responses to vaccination or infection.

Our investigators use a wide range of genetic, genomic, proteomic, immunologic and molecular approaches. To facilitate these patient-oriented research activities, some of our scientists are also developing novel methods to mine large datasets and evaluate complex human genetic diseases.

In addition, the Arthritis and Clinical Immunology program houses resources that are essential for many investigators in our program and in the larger autoimmune disease research community. These include the Biorepository Core, Clinical Immunology Laboratory, Myositis Testing Laboratory, Human Antibody Core, Quantitative Analysis Core, Clinical Genomics Center and Phenotyping Core. Many of these cores were established and funded through ongoing federal grants, leveraging equipment purchased and serviced by OMRF. Our investigators also benefit from departmental journal clubs, seminar series, intentional mentorship and collaborative, multi-investigator scientific projects.

Arthritis & Clinical Immunology

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Division of Genomics & Data Sciences

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Multiple Sclerosis Center of Excellence

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Rheumatology Center of Excellence

2018

Bagavant H, Dunkleberger ML, Wolska N, Sroka M, Rasmussen A, Adrianto I, Montgomery C, Sivils K, Guthridge JM, James JA, Merrill JT, Deshmukh US.   Antibodies to periodontogenic bacteria are associated with higher disease activity in lupus patients.  Clin Exp Rheumatol. 2018 Jun 25. PMID:29998833

Bermas BL, Tassinari M, Clowse M, Chakravarty E.  The new FDA labeling rule: impact on prescribing rheumatological medications during pregnancy.   Rheumatology (Oxford). 2018 Jul 1;57(suppl_5):v2-v8. Review.  PMID:30137587

Bin Joo Y, Lim J, Tsao BP, Nath SK, Kim K, Bae SC.  Genetic variants in systemic lupus erythematosus susceptibility loci, XKR6 and GLT1D1 are associated with childhood-onset SLE in a Korean cohort. Sci Rep. 2018 Jul 2;8(1):9962. PMID:29967481

Black CD, Schubert DJ, Szczyglowski MK, Wren JD.  Carbohydrate Mouth Rinsing Does Not Prevent the Decline in Maximal Strength After Fatiguing Exercise.  J Strength Cond Res. 2018 Sep;32(9):2466-73.   PMID:29334582

Brito-Zerón P, Acar-Denizli N, Ng WF, Zeher M, Rasmussen A, Mandl T, Seror R, Li X, Baldini C, Gottenberg JE, Danda D, Quartuccio L, Priori R, Hernandez-Molina G, Armagan B, Kruize AA, Kwok SK, Kvarnström M, Praprotnik S, Sène D, Bartoloni E, Solans R, Rischmueller M, Suzuki Y, Isenberg DA, Valim V, Wiland P, Nordmark G, Fraile G, Bootsma H, Nakamura T, Giacomelli R, Devauchelle-Pensec V, Knopf A, Bombardieri M, Trevisani VF, Hammenfors D, Pasoto SG, Retamozo S, Gheita TA, Atzeni F, Morel J, Vollenveider C, Horvath IF, Sivils KL, Olsson P, De Vita S, Sánchez-Guerrero J, Kilic L, Wahren-Herlenius M, Mariette X, Ramos-Casals M; Sjögren Big Data Consortium.  How immunological profile drives clinical phenotype of primary Sjögren's syndrome at diagnosis: analysis of 10,500 patients (Sjögren Big Data Project).    Clin Exp Rheumatol. 2018 May-Jun;36 Suppl 112(3):102-12.  PMID:30156539

Celada LJ, Kropski JA, Herazo-Maya JD, Luo W, Creecy A, Abad AT, Chioma OS, Lee G, Hassell NE, Shaginurova GI, Wang Y, Johnson JE, Kerrigan A, Mason WR, Baughman RP, Ayers GD, Bernard GR, Culver DA, Montgomery CG, Maher TM, Molyneaux PL, Noth I, Mutsaers SE, Prele CM, Peebles RS Jr, Newcomb DC, Kaminski N, Blackwell TS, Van Kaer L, Drake WP.    PD-1 up-regulation on CD4⁺ T cells promotes pulmonary fibrosis through STAT3-mediated IL-17A and TGF-β1 production.  Sci Transl Med. 2018 Sep 26;10(460). pii: eaar8356.  PMID:30257954

Choi MY, Clarke AE, St Pierre Y, Hanly JG, Urowitz MB, Romero-Diaz J, Gordon C, Bae SC, Bernatsky S, Wallace DJ, Merrill JT, Isenberg DA, Rahman A, Ginzler EM, Petri M, Bruce IN, Dooley MA, Fortin PR, Gladman DD, Sanchez-Guerrero J, Steinsson K, Ramsey-Goldman R, Khamashta MA, Aranow C, Alarcón GS, Manzi S, Nived O, Zoma AA, van Vollenhoven RF, Ramos-Casals M, Ruiz-Irastorza G, Lim SS, Kalunian KC, Inanc M, Kamen DL, Peschken CA, Jacobsen S, Askanase A, Stoll T, Buyon J, Mahler M, Fritzler MJ.    Antinuclear Antibody-Negative Systemic Lupus Erythematosus in an International Inception Cohort.   Arthritis Care Res (Hoboken). 2018 Jul 25.   PMID:30044551

Clowse MEB, Eudy AM, Kiernan E, Williams MR, Bermas B, Chakravarty E, Sammaritano LR, Chambers CD, Buyon J.  The prevention, screening and treatment of congenital heart block from neonatal lupus: a survey of provider practices.   Rheumatology (Oxford). 2018 Jul 1;57(suppl_5):v9-v17.   PMID:30137589

Fjeldstad-Pardo C, Thiessen A, Pardo G. Telerehabilitation in Multiple Sclerosis: Results of a Randomized Feasibility and Efficacy Pilot Study.  Int J Telerehabil. 2018 Dec 11;10(2):55-64. PMID:30588276

Fu Y, Tessneer KL, Li C, Gaffney PM.  From association to mechanism in complex disease genetics: the role of the 3D genome.  Arthritis Res Ther. 2018 Sep 29;20(1):216.  Review. PMID:30268153

Georgescu C, Wren JD.  Algorithmic identification of discrepancies between published ratios and their reported confidence intervals and p-values.   Bioinformatics. 2017 Dec 22. PMID:29309530

Hanly JG, Li Q, …, Merrill JT, et al.  Cerebrovascular Events in Systemic Lupus Erythematosus.   Arthritis Care Res (Hoboken). 2018 Jan 5. PMID:29316357 

Hanly JG, Li Q, Su L, Urowitz MB, Gordon C, Bae SC, Romero-Diaz J, Sanchez-Guerrero J, Bernatsky S, Clarke AE, Wallace DJ, Isenberg DA, Rahman A, Merrill JT, Fortin PR, Gladman DD, Bruce IN, Petri M, Ginzler EM, Dooley MA, Steinsson K, Ramsey-Goldman R, Zoma AA, Manzi S, Nived O, Jonsen A, Khamashta MA, Alarcón GS, van Vollenhoven RF, Aranow C, Mackay M, Ruiz-Irastorza G, Ramos-Casals M, Sam Lim S, Inanc M, Kalunian KC, Jacobsen S, Peschken CA, Kamen DL, Askanase A, Theriault C, Farewell V.    Psychosis in Systemic Lupus Erythematosus.  Arthritis Rheumatol. 2018 Oct 30.   PMID:30375754

Hanscombe KB, Morris DL, Noble JA, Dilthey AT, Tombleson P, Kaufman KM, Comeau M, Langefeld CD, Alarcon-Riquelme ME, Gaffney PM, Jacob CO, Sivils KL, Tsao BP, Alarcon GS, Brown EE, Croker J, Edberg J, Gilkeson G, James JA, Kamen DL, Kelly JA, McCune J, Merrill JT, Petri M, Ramsey-Goldman R, Reveille JD, Salmon JE, Scofield H, Utset T, Wallace DJ, Weisman MH, Kimberly RP, Harley JB, Lewis CM, Criswell LA, Vyse TJ. Genetic fine mapping of systemic lupus erythematosus MHC associations in Europeans and African Americans.  Hum Mol Genet. 2018 Nov 1;27(21):3813-24.   PMID:30085094

Harper AR, Le AT, Mather T, Burgett A, Berry W, Summers JA. Design, synthesis, and ex vivo evaluation of a selective inhibitor for retinaldehyde dehydrogenase enzymes.  Bioorg Med Chem. 2018 Dec 1;26(22):5766-79.  Oct 24.  PMID:30409702

Huang C, Fu C, Wren JD, Wang X, Zhang F, Zhang YH, Connel SA, Chen T, Zhang XA.   Tetraspanin-enriched microdomains regulate digitation junctions.  Cell Mol Life Sci. 2018 Sep;75(18):3423-39. Mar 27. Erratum in: Cell Mol Life Sci. 2018 Nov;75(21):4077. PMID:29589089

Correction to: Tetraspanin-enriched microdomains regulate digitation junctions.  Huang C, Fu C, Wren JD, Wang X, Zhang F, Zhang YH, Connell SA, Chen T, Zhang XA.  Cell Mol Life Sci. 2018 Nov;75(21):4077.  PMID:30196315

Jog NR, Chakravarty EF, Guthridge JM, James JA.  Epstein Barr Virus Interleukin 10 Suppresses Anti-inflammatory Phenotype in Human Monocytes.    Front Immunol. 2018 Oct 9;9:2198.   PMID:30356670

Kadel S, Kovats S.  Infection.  Front Immunol. 2018 Jul 20;9:1653. Review.  PMID:30079065

Karp DR, Chong BF, James JA, Arriens C, Ishimori M, Wallace DJ, Liao D, Olsen NJ.  Mock Recruitment for the Study of Antimalarials in Incomplete Lupus Erythematosus Trial.  Arthritis Care Res (Hoboken). 2018 Oct 28.  PMID:30369087

Kim M, Merrill JT, Kalunian K, Hanrahan L, Izmirly P. Evaluating duration of response to treatment in systemic lupus erythematosus clinical trials.  Lupus Sci Med. 2018 Aug 6;5(1):e000266.  PMID:30319781

Kim MY, Guerra MM, Kaplowitz E, Laskin CA, Petri M, Branch DW, Lockshin MD, Sammaritano LR, Merrill JT, Porter TF, Sawitzke A, Lynch AM, Buyon JP, Salmon JE.  Complement activation predicts adverse pregnancy outcome in patients with systemic lupus erythematosus and/or antiphospholipid antibodies.  Ann Rheum Dis. 2018 Jan 25:annrheumdis-2017-212224. PMID:29371202

Kinney N, Titus-Glover K, Wren JD, Varghese RT, Michalak P, Liao H, Anandakrishnan R, Pulenthiran A, Kang L, Garner HR.  CAGm: a repository of germline microsatellite variations in the 1000 genomes project.   Nucleic Acids Res. 2018 Oct 17.  PMID:30329086

Kishi T, Bayat N, Ward MM, Huber AM, Wu L, Mamyrova G, Targoff IN, Warren-Hicks WJ, Miller FW, Rider LG; Childhood Myositis Heterogeneity Study Group. Medications received by patients with juvenile dermatomyositis. Semin Arthritis Rheum. 2018 Mar 28. pii: S0049-0172(17)30753-9.  PMID:29773230

Kivitz A, Olech E, Borofsky MA, Zazueta B, Navarro-Sarabia F, Radominski SC, Merrill JT, Pacheco-Tena C, Pei J, Nasmyth-Miller C, Pope JE.   Two-year Efficacy and Safety of Subcutaneous Tocilizumab in Combination with Disease-modifying Antirheumatic Drugs Including Escalation to Weekly Dosing in Rheumatoid Arthritis. J Rheumatol. 2017 Dec 15:jrheum.161539. PMID:29247149

* Kondo Y, Fu J, Wang H, Hoover C, McDaniel JM, Steet R, Patra D, Song J, Pollard L, Cathey S, Yago T, Wiley G, Macwana S, Guthridge J, McGee S, Li S, Griffin C, Furukawa K, James JA, Ruan C, McEver RP, Wierenga KJ, Gaffney PM, Xia L.  Site-1 protease deficiency causes human skeletal dysplasia due to defective inter-organelle protein trafficking.   JCI Insight. 2018 Jul 26;3(14). pii: 121596.   PMID:30046013

Kottyan LC, Maddox A, Braxton JR, Stucke EM, Mukkada V, Putnam PE, Abonia JP, Chehade M, Wood RA, Pesek RD, Vickery BP, Furuta GT, Dawson P, Sampson HA, Martin LJ, Kelly JA, Kimberly RP, Sivils K, Gaffney PM, Kaufman K, Harley JB, Rothenberg ME.  Genetic variants at the 16p13 locus confer risk for eosinophilic esophagitis. Genes Immun. 2018 Jun 8.  PMID 29904099

Kurien BT, Dorri Y, Scofield RH.   Curcumin/Turmeric as an Environment-Friendly Protein Gel Stain.  Methods Mol Biol. 2018;1853:121-31.   PMID:30097937

Kurien BT, Scofield RH.   Sex Hormones Regulate Innate Immune Cells and Promote Sex Differences in Respiratory Virus Stained Gels Can Be Stored for Several Months in Nonsealed Polyethylene Bags.  Methods Mol Biol. 2018;1853:273-9.  PMID:30097954

Kurien BT, Scofield RH.  Application of Heat to Quickly Stain and Destain Proteins Stained with Coomassie Blue.  Methods Mol Biol. 2018;1853:37-45.   PMID:30097928

Kurien BT, Thomas R, Payne A, Scofield RH.  Heat/Pressure Treatment with Detergents Significantly Increases Curcumin Solubility and Stability: Its Use as an Environment-Friendly Protein Gel Stain.  Methods Mol Biol. 2018;1853:237-46.  PMID:30097949

Le TT, Savitz J, Suzuki H, Misaki M, Teague TK, White BC, Marino JH, Wiley G, Gaffney PM, Drevets WC, McKinney BA, Bodurka J.   Identification and replication of RNA-Seq gene network modules associated with depression severity.   Transl Psychiatry. 2018 Sep 5;8(1):180. PMID:30185774

Little J, Parker B, Lunt M, …, Merrill JT, et al.  Glucocorticoid use and factors associated with variability in this use in the Systemic Lupus International Collaborating Clinics Inception Cohort.   Rheumatology (Oxford). 2018 Jan 18. PMID:29361147

Mamyrova G, Kishi T, Targoff IN, Ehrlich A, Curiel RV, Rider LG; Childhood Myositis Heterogeneity Collaborative Study Group.  Features distinguishing clinically amyopathic juvenile dermatomyositis from juvenile dermatomyositis.  Rheumatology (Oxford). 2018 Nov 1;57(11):1956-63.   PMID:30016492

Martínez-Bueno M, Oparina N, Dozmorov MG, Marion MC, Comeau ME, Gilkeson G, Kamen D, Weisman M, Salmon J, McCune JW, Harley JB, Kimberly R, James JA, Merrill J, Montgomery C, Langefeld CD, Alarcón-Riquelme ME.  Trans-Ethnic Mapping of BANK1 Identifies Two Independent SLE-Risk Linkage Groups Enriched for Co-Transcriptional Splicing Marks.   Int J Mol Sci. 2018 Aug 8;19(8). pii: E2331.   PMID:30096841

Mendel A, Bernatsky SB, Hanly JG, Urowitz MB, Clarke AE, Romero-Diaz J, Gordon C, Bae SC, Wallace DJ, Merrill JT, Buyon JP, Isenberg DA, Rahman A, Ginzler EM, Petri M, Dooley MA, Fortin PR, Gladman DD, Steinsson K, Ramsey-Goldman R, Khamashta MA, Aranow C, Mackay M, Alarcón GS, Manzi S, Nived O, Jönsen A, Zoma AA, van Vollenhoven RF, Ramos-Casals M, Ruiz-Irastorza G, Lim S, Kalunian KC, Inanc M, Kamen DL, Peschken CA, Jacobsen S, Askanase A, Sanchez-Guerrero J, Bruce IN, Costedoat-Chalumeau N, Vinet É.   Low aspirin use and high prevalence of pre-eclampsia risk factors among pregnant women in a multinational SLE inception cohort. Ann Rheum Dis. 2018 Dec 20. pii: annrheumdis-2018-214434 No abstract available.  PMID:30573656

Merrill JT, Furie R, Werth VP, Khamashta M, Drappa J, Wang L, Illei G, Tummala R.  Anifrolumab effects on rash and arthritis: impact of the type I interferon gene signature in the phase IIb MUSE study in patients with systemic lupus erythematosus. Lupus Sci Med. 2018 Nov 26;5(1):e000284. PMID:30588322

Merrill JT, Petri MA, Buyon J, Ramsey-Goldman R, Kalunian K, Putterman C, Conklin J, Furie RA, Dervieux T. Erythrocyte-bound C4d in combination with complement and autoantibody status for the monitoring of SLE.  Lupus Sci Med. 2018 May 23;5(1):e000263. PMID:29868177

Mollard E, Pedro S, Chakravarty E, Clowse M, Schumacher R, Michaud K. The impact of menopause on functional status in women with rheumatoid arthritis.  Rheumatology (Oxford). 2018 Jan 29. PMID:29385538

Olsen NJ, James JA, Arriens C, Ishimori ML, Wallace DJ, Kamen DL, Chong BF, Liao D, Chinchilli VM, Karp DR. Study of Anti-Malarials in Incomplete Lupus Erythematosus (SMILE): study protocol for a randomized controlled trial.  Trials. 2018 Dec 20;19(1):694.  PMID:30572906

Patel Z, Lu X, Miller D, Forney CR, Lee J, Lynch A, Schroeder C, Parks L, Magnusen AF, Chen X, Pujato M, Maddox A, Zoller EE, Namjou B, Brunner HI, Henrickson M, Huggins JL, Williams AH, Ziegler JT, Comeau ME, Marion MC, Glenn SB, Adler A, Shen N, Nath SK, Stevens AM, Freedman BI, Pons-Estel BA, Tsao BP, Jacob CO, Kamen DL, Brown EE, Gilkeson GS, Alarcón GS, Martin J, Reveille JD, Anaya JM, James JA, Sivils KL, Criswell LA, Vilá LM, Petri M, Scofield RH, Kimberly RP, Edberg JC, Ramsey-Goldman R, Bang SY, Lee HS, Bae SC, Boackle SA, Cunninghame Graham D, Vyse TJ, Merrill JT, Niewold TB, Ainsworth HC, Silverman ED, Weisman MH, Wallace DJ, Raj P, Guthridge JM, Gaffney PM, Kelly JA, Alarcón-Riquelme ME, Langefeld CD, Wakeland EK, Kaufman KM, Weirauch MT, Harley JB, Kottyan LC.   A plausibly causal functional lupus-associated risk variant in the STAT1-STAT4 locus.  Hum Mol Genet. 2018 Apr 18. PMID:29912393

Pelikan RC, Kelly JA, Fu Y, Lareau CA, Tessneer KL, Wiley GB, Wiley MM, Glenn SB, Harley JB, Guthridge JM, James JA, Aryee MJ, Montgomery C, Gaffney PM.  Enhancer histone-QTLs are enriched on autoimmune risk haplotypes and influence gene expression within chromatin networks.  Nat Commun. 2018 Jul 25;9(1):2905.   PMID:30046115

*Popescu NI, Silasi R, Keshari RS, Girton A, Burgett T, Zeerleder SS, Gailani D, Gruber A, Lupu F, Coggeshall KM.  Peptidoglycan induces disseminated intravascular coagulation in baboons through activation of both coagulation pathways.  Blood. 2018 Jun 19. pii: blood-2017-10-813618. PMID:29921614

Quinn JL, Axtell RC.   Emerging Role of Follicular T Helper Cells in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis. Int J Mol Sci. 2018 Oct 19;19(10). pii: E3233. Review.  PMID:30347676

Ratliff ML, Garton J, Garman L, Barron MD, Georgescu C, White KA, Chakravarty E, Wren JD, Montgomery CG, James JA, Webb CF.  ARID3a gene profiles are strongly associated with human interferon alpha production.  J Autoimmun. 2018 Oct 5. pii: S0896-8411(18)30433-5.  PMID:30297159

Scofield RH.  Physical Examination - Still Relevant in Sjögren Syndrome.    J Rheumatol. 2018 Nov;45(11):1495-6. No abstract available.  PMID:30385694

Singh B, Nath SK.   Identification of Proteins Interacting with Single Nucleotide Polymorphisms (SNPs) by DNA Pull-Down Assay.  Methods Mol Biol. 2019;1855:355-62.   PMID:30426431

Sroka M, Bagavant H, Biswas I, Ballard A, Deshmukh US.  Immune response against the coiled coil domain of Sjögren's syndrome associated autoantigen Ro52 induces salivary gland dysfunction.  Clin Exp Rheumatol. 2018 Jan 31.  PMID:29465352

Thanou A, Merrill JT.  Curr Rheumatol Rep. 2018 May 3;20(6):34. Review. PMID:29725880

Trieu EP, Targoff IN. SDS-PAGE for ³⁵S Immunoprecipitation and Immunoprecipitation Western Blotting.   Methods Mol Biol. 2019;1855:417-36.   PMID:30426436

Trzeciak M, Bagavant H, Papinska J, Deshmukh US.   Immune Response Targeting Sjögren's Syndrome Antigen Ro52 Suppresses Tear Production in Female Mice.   Int J Mol Sci. 2018 Sep 27;19(10). pii: E2935.   PMID:30261673

Ungvari Z, Tarantini S, Kiss T, Wren JD, Giles CB, Griffin CT, Murfee WL, Pacher P, Csiszar A.  Endothelial dysfunction and angiogenesis impairment in the ageing vasculature.  Nat Rev Cardiol. 2018 May 24. Review. PMID:29795441

Unnikrishnan A, Freeman WM, Jackson J, Wren JD, Porter H, Richardson A.  The role of DNA methylation in epigenetics of aging.   Pharmacol Ther. 2018 Nov 9. pii: S0163-7258(18)30198-0. Review.  PMID:30419258

Vinet E, Chakravarty EF, Clowse MEB.  Power in numbers.    Rheumatology (Oxford). 2018 Jul 1;57(suppl_5):v40-v47.  PMID:30137590

Wang CC, Ortiz-González XR, Yum SW, Gill SM, White A, Kelter E, Seaver LH, Lee S, Wiley G, Gaffney PM, Wierenga KJ, Rasband MN.  βIV Spectrinopathies Cause Profound Intellectual Disability, Congenital Hypotonia, and Motor Axonal Neuropathy.  Am J Hum Genet. 2018 Jun 7;102(6):1158-68. PMID:29861105

Wren JD.  Algorithmically outsourcing the detection of statistical errors and other problems.  EMBO J. 2018 May 24.e99651. No abstract available.  PMID:29794111

Yeker RM, Pinal-Fernandez I, Kishi T, Pak K, Targoff IN, Miller FW, Rider LG, Mammen AL; Childhood Myositis Heterogeneity Collaborative Study Group.  Anti-NT5C1A autoantibodies are associated with more severe disease in patients with juvenile myositis.  Ann Rheum Dis.  2018 May;77(5):714-9.  PMID:29363513

Young KA, Munroe ME, Harley JB, Guthridge JM, Kamen DL, Gilkensen GS, Weisman MH, Karp DR, Wallace DJ, James JA, Norris JM. Less than 7 hours of sleep per night is associated with transitioning to systemic lupus erythematosus. Lupus.2018 Jan 1:961203318778368. PMID: 29804502

2017

Aberle T, Bourn RL, Chen H, Roberts VC, Guthridge JM, Bean K, Robertson JM, Sivils KL, Rasmussen A, Liles M, Merrill JT, Harley JB, Olsen NJ, Karp DR, James JA. Use of SLICC criteria in a large, diverse lupus registry enables SLE classification of a subset of ACR-designated subjects with incomplete lupus. Lupus Sci Med. 2017 Mar 17;4(1):e000176. eCollection 2017.  PMCID: PMC5372139

Aberle T, Bourn RL, Munroe ME, Chen H, Roberts VC, Guthridge JM, Bean K, Robertson JM, Sivils KL, Rasmussen A, Liles M, Merrill JT, Harley JB, Olsen NJ, Karp DR, James JA. Clinical and serological features distinguish patients with incomplete lupus classification from systemic lupus erythematosus patients and controls. Arthritis Care Res (Hoboken). 2017 Jan 24.  PMID: 28118528

Adrianto I, Montgomery C.  Estimating Allele Frequencies. Methods Mol Biol. 2017;1666:61-81. PMID:22307694

Ainsworth HC, Marion MC, Bertero T, Brucato A, Cimaz R, Costedoat-Chalumeau N, Fredi M, Gaffney P, Kelly J, Levesque K, Maltret A, Morel N, Ramoni V, Ruffatti A, Langefeld CD, Buyon JP, Clancy RM.  Association of Natural Killer Cell Ligand Polymorphism HLA-C Asn80Lys with the Development of Anti-SSA/Ro-Associated Congenital Heart Block.  Arthritis Rheumatol. 2017 Nov;69(11):2170-4.PMCID:PMC5679096

Arriens C, Chen S, Karp DR, Saxena R, Sambandam K, Chakravarty E, James JA, Merrill JT. Prognostic significance of repeat biopsy in lupus nephritis: Histopathologic worsening and a short time between biopsies is associated with significantly increased risk for end stage renal disease and death. Clin Immunol. 2016 Dec 3. pii: S1521-6616(16)30668-4.   PMCID: PMC5457715

Arriens C, Wren JD, Munroe ME, Mohan C. Systemic lupus erythematosus biomarkers: the challenging quest. Rheumatology (Oxford). 2017 Apr 1;56(suppl_1):i32-i45.  PMID: 28013203

Askanase AD, Nguyen SC, Costenbader K, Lim SS, Kamen D, Aranow C, Grossman J, Kapoor TM, Baker-Frost D, Aberle T, Thanou-Stavraki A, Hanrahan LM, Kim M, Merrill JT.  A Rapid Evaluation of Activity in Lupus (LFA-REAL^™) Correlates with More Complex Disease Activity Instruments Whether Evaluated by Clinical Investigators or Real-World Clinicians. Arthritis Care Res (Hoboken). 2017 Oct 9. PMID:28992399

*Barboza E, Hudson J, Chang WP, Kovats S, Towner RA, Silasi-Mansat R, Lupu F, Kent C, Griffin TM. Pro-fibrotic infrapatellar fat pad remodeling without M1-macrophage polarization precedes knee osteoarthritis in diet-induced obese mice. Arthritis Rheumatol. 2017 Jun;69(6):1221-32. PMCID: PMC5449220

Berkovich R, Bakshi R, Amezcua L, Axtell RC, Cen SY, Tauhid S, Neema M, Steinman L. Adrenocorticotropic hormone versus methylprednisolone added to interferon β in patients with multiple sclerosis experiencing breakthrough disease: a randomized, rater-blinded trial. Ther Adv Neurol Disord. 2017 Jan;10(1):3-17. PMCID: PMC5400152

Bhat R, Mahapatra S, Axtell RC, Steinman L. Amelioration of ongoing experimental autoimmune encephalomyelitis with fluoxetine. J Neuroimmunol. 2017 Dec 15;313:77-81.  PMID: 29153612

Braun DA, Rao J, Mollet G, …, Gaffney PM, et al.  Mutations in KEOPS-complex genes cause nephrotic syndrome with primary microcephaly. Nat Genet. 2017 Oct;49(10):1529-38. PMID:28805828

Buckley DA, Jennings EM, Burke NN, Roche M, McInerney V, Wren JD, Finn DP, McHugh PC. Erratum to: The Development of Translational Biomarkers as a Tool for Improving the Understanding, Diagnosis and Treatment of Chronic Neuropathic Pain. Mol Neurobiol. 2017 Jul 1.  PMID: 28669124

Carapito R, Gottenberg JE, Kotova I, Untrau M, Michel S, Naegely L, Aouadi I, Kwemou M, Paul N, Pichot A, Locke J, Bowman SJ, Griffiths B, Sivils KL, Sibilia J, Inoko H, Micelli-Richard C, Nocturne G, Ota M, Ng WF, Mariette X, Bahram S. A new MHC-linked susceptibility locus for primary Sjögren's syndrome: MICA. Hum Mol Genet. 2017 Apr 4.  PMID: 28379387

Choi MY, Clarke AE, St Pierre Y, Hanly JG, Urowitz MB, Romero-Diaz J, Gordon C, Bae SC, Bernatsky S, Wallace DJ, Merrill JT, Isenberg DA, Rahman A, Ginzler EM, Petri M, Bruce IN, Dooley MA, Fortin P, Gladman DD, Sanchez-Guerrero J, Steinsson K, Ramsey-Goldman R, Khamashta MA, Aranow C, Alarcón GS, Manzi S, Nived O, Zoma AA, van Vollenhoven RF, Ramos-Casals M, Ruiz-Irastorza G, Lim SS, Kalunian KC, Inanc M, Kamen DL, Peschken CA, Jacobsen S, Askanase A, Buyon J, Mahler M, Fritzler MJ. The prevalence and determinants of anti-DFS70 autoantibodies in an international inception cohort of systemic lupus erythematosus patients. Lupus. 2017 Jan 1:961203317692437.  PMID: 28420054

Danda D, Goel R, Danda S, Mohan H, Joseph G, Kabeerdoss J, Nath SK. Interleukin-17F and Interleukin-6 gene polymorphisms in Asian Indian patients with Takayasu arteritis. Hum Immunol. 2017 Apr 21. pii: S0198-8859(17)30070-8.   PMID: 28438554

Danda D, Sharma R, Truong D, Koelsch KA, Kurien BT, Bagavant H, Deshmukh U, Kaufman CE, Lewis DM, Stone DU, Radfar L, Rasmussen A, Sivils KL, Scofield RH. Anti-La positive, anti-Ro negative subset of primary Sjögren's syndrome: anti-La is a reality but is the disease? Clin Exp Rheumatol. 2017 Feb 20.  PMID: 28229827

Dumas EK, Garman L, Cuthbertson H, Charlton S, Hallis B, Engler RJM, Choudhari S, Picking WD, James JA, Farris AD. Lethal factor antibodies contribute to lethal toxin neutralization in recipients of anthrax vaccine precipitated. Vaccine. 2017 Jun 8;35(26):3416-22.   PMID: 28504191

*Fields E, Wren JD, Georgescu C, Daum JR, Gorbsky GJ. Predictive bioinformatics identifies novel regulators of proliferation in a cancer stem cell model. Stem Cell Res. 2017 Nov 21;26:1-7. PMID:29179130

Furie R, Khamashta M, Merrill JT, Werth VP, Kalunian K, Brohawn P, Illei GG, Drappa J, Wang L, Yoo S; CD1013 Study Investigators.  Anifrolumab, an Anti-Interferon-α Receptor Monoclonal Antibody, in Moderate-to-Severe Systemic Lupus Erythematosus. Arthritis Rheumatol. 2017 Feb;69(2):376-86.   PMCID: PMC5299497

Garbett NC, Brock GN, Chaires JB, Mekmaysy CS, DeLeeuw L, Sivils KL, Harley JB, Rovin BH, Kulasekera KB, Jarjour WN.  Characterization and classification of lupus patients based on plasma thermograms.  PLoS One. 2017 Nov 17;12(11):e0186398. eCollection 2017. PMCID:PMC5693473

Gensterblum E, Renauer P, Coit P, Strickland FM, Kilian NC, Miller S, Ognenovski M, Wren JD, Tsou PS, Lewis EE, Maksimowicz-McKinnon K, McCune WJ, Richardson BC, Sawalha AH.  CD4+CD28+KIR+CD11a^hi T cells correlate with disease activity and are characterized by a pro-inflammatory epigenetic and transcriptional profile in lupus patients.  J Autoimmun. 2017 Oct 20. pii: S0896-8411(17)30596-6. PMID:29066026 

Georgescu C, Wren JD.  Algorithmic identification of discrepancies between published ratios and their reported confidence intervals and p-values.  Bioinformatics. 2017 Dec 22.  PMID:29309530

Glauzy S, Boccitto M, Bannock JM, Delmotte FR, Saadoun D, Cacoub P, Ice JA, Sivils KL, James JA, Wolin SL, Meffre E.  Antigen-driven lymphoproliferations in Sjögren's Syndrome patients accumulate in complement receptor 2/CD21^-/low B cells.  Arthritis Rheumatol. 2017 Oct 26. PMID:29073352

Gough AT, Fieraru G, Gaffney P, Butler M, Kincaid RJ, Middleton RG. A novel use of QR code stickers after orthopaedic cast application. Ann R Coll Surg Engl. 2017 Jul;99(6):476-478. PMID: 28660817

Harris VM, Sharma R, Cavett J, Kurien BT, Liu K, Koelsch KA, Rasmussen A, …, Lessard CJ, Harley JB, Sivils KL, Scofield HR.  Corrigendum to "Klinefelter's syndrome (47,XXY) is in excess among men with Sjögren's syndrome" Clin Immunol. 2017 Nov 28. pii: S1521-6616(17)30854-9. PMID:29195081 

He X, Cheng R, Park K, Benyajati S, Moiseyev G, Sun C, Olson LE, Yang Y, Eby BK, Lau K, Ma JX. Pigment epithelium-derived factor, a noninhibitory serine protease inhibitor, is renoprotective by inhibiting the Wnt pathway. Kidney Int. 2017 Mar;91(3):642-57.   PMCID: PMC5313326

Heinlen L, Chakravarty EF.  Reproductive Health Screening in Women with Autoimmune Diseases. Rheum Dis Clin North Am. 2017 May;43(2):161-71. Review. PMID: 28390560

*Hopiavuori BR, Deák F, Wilkerson JL, Brush RS, Rocha-Hopiavuori NA, Hopiavuori AR, Ozan KG, Sullivan MT, Wren JD, Georgescu C, Szweda L, Awasthi V, Towner R, Sherry DM, Anderson RE, Agbaga MP.  Homozygous Expression of Mutant ELOVL4 Leads to Seizures and Death in a Novel Animal Model of Very Long-Chain Fatty Acid Deficiency.  Mol Neurobiol. 2017 Nov 22. PMID:29168048

Isenberg D, Sturgess J, Allen E, Aranow C, Askanase A, Sang-Cheol B, Bernatsky S, Bruce I, Buyon J, Cervera R, Clarke A, Dooley MA, Fortin P, Ginzler E, Gladman D, Hanly J, Inanc M, Jacobsen S, Kamen D, Khamashta M, Lim S, Manzi S, Nived O, Peschken C, Petri M, Kalunian K, Rahman A, Ramsey-Goldman R, Ruiz-Irastorza G, Sanchez-Guerrero J, Steinsson K, Sturfelt G, Urowitz M, van Vollenhoven R, Wallace DJ, Zoma A, Merrill J, Gordon C. A study of flare assessment in systemic lupus erythematosus (SLE) based on paper patients. Arthritis Care Res (Hoboken). 2017 Apr 7.   PMID: 28388813

Kalunian KC, Urowitz MB, Isenberg D, Merrill JT, Petri M, Furie RA, Morgan-Cox MA, Taha R, Watts S, Silk M, Linnik MD.  Clinical trial parameters that influence outcomes in lupus trials that use the systemic lupus erythematosus responder index. Rheumatology (Oxford). 2017 Oct 17. PMID:29045736

Kaplowitz ET, Ferguson S, Guerra M, Laskin CA, Buyon JP, Petri M, Lockshin MD, Sammaritano LR, Branch DW, Merrill JT, Katz P, Salmon JE.  Socioeconomic Status Contributes to Racial/Ethnic Disparities in Adverse Pregnancy Outcomes among Women with Systemic Lupus Erythematosus. Arthritis Care Res (Hoboken). 2017 May 8.   PMID: 28480528

Kim M, Merrill J, Kalunian K, Hahn B, Roach A, Izmirly P; Lupus Foundation of America Collective Data Analysis Initiative Group.. Brief Report: Longitudinal Patterns of Response to Standard of Care Therapy for Systemic Lupus Erythematosus: Implications for Clinical Trial Design. Arthritis Rheumatol. 2017 Apr;69(4):785-90.  PMID: 27992696

Kishi T, Rider LG, Pak K, Barillas-Arias L, Henrickson M, McCarthy PL, Shaham B, Weiss PF, Horkayne-Szakaly I, Targoff IN, Miller FW, Mammen AL; Childhood Myositis Heterogeneity Study Group.. Anti-3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase Autoantibodies are Associated with DRB1*07:01 and Severe Myositis in Pediatric Myositis Patients. Arthritis Care Res (Hoboken). 2017 Jan 27. PMID: 28129483

Kivitz A, Olech E, Borofsky MA, Zazueta B, Navarro-Sarabia F, Radominski SC, Merrill JT, Pacheco-Tena C, Pei J, Nasmyth-Miller C, Pope JE.  Two-year Efficacy and Safety of Subcutaneous Tocilizumab in Combination with Disease-modifying Antirheumatic Drugs Including Escalation to Weekly Dosing in Rheumatoid Arthritis.  J Rheumatol. 2017 Dec 15. pii: jrheum.161539.  PMID:29247149 

Kurien BT, Matsumoto H, Scofield RH. Nutraceutical Value of Pure Curcumin. Pharmacogn Mag. 2017 Jan;13(Suppl 1):S161-63.   PMCID: PMC5407110

Kurien BT, Scofield RH. Validating Antibody Specificities for Immunohistochemistry by Protein Blotting Methods. Methods Mol Biol. 2017;1554:61-73. PMID: 28185183

Landrian I, McFarland KN, Liu J, Mulligan CJ, Rasmussen A, Ashizawa T. Inheritance patterns of ATCCT repeat interruptions in spinocerebellar ataxia type 10 (SCA10) expansions. PLoS One. 2017 Apr 19;12(4):e0175958.  eCollection 2017.  PMCID: PMC5397023

Langefeld CD, Ainsworth HC, Cunninghame Graham DS, ...Guthridge JM, Huggins  JL, James JA, ... Merrill JT, Miranda P, Moctezuma JF, Nath SK, ... Sivils KL, ... Alarcón-Riquelme ME, ..., Gaffney PM, Vyse TJ. Transancestral mapping and genetic load in systemic lupus erythematosus. Nat Commun. 2017 Jul 17;8:16021.  PMCID: PMC5520018

Leehan KM, Pezant NP, Rasmussen A, Grundahl K, Moore JS, Radfar L, Lewis DM, Stone DU, Lessard CJ, Rhodus NL, Segal BM, Kaufman CE, Scofield RH, Sivils KL, Montgomery C, Farris AD.  Fatty infiltration of the minor salivary glands is a selective feature of aging but not Sjögren's syndrome. Autoimmunity. 2017 Oct 8:1-7. PMID:28988489 

Leehan KM, Pezant NP, Rasmussen A, Grundahl K, Moore JS, Radfar L, Lewis DM, Stone DU, Lessard CJ, Rhodus NL, Segal BM, Scofield RH, Sivils KL, Montgomery C, Farris AD.  Minor salivary gland fibrosis in Sjögren's syndrome is elevated, associated with focus score and not solely a consequence of aging.  Clin Exp Rheumatol. 2017 Oct 23.PMID:29148407

Li H, Reksten TR, Ice JA, Kelly JA, Adrianto I, Rasmussen A, Wang S, He B, Grundahl KM, Glenn SB, Miceli-Richard C, Bowman S, Lester S, Eriksson P, Eloranta ML, Brun JG, Gøransson LG, Harboe E, Guthridge JM, Kaufman KM, Kvarnström M, Cunninghame Graham DS, Patel K, Adler AJ, Farris AD, Brennan MT, Chodosh J, Gopalakrishnan R, Weisman MH, Venuturupalli S, Wallace DJ, Hefner KS, Houston GD, Huang AJW, Hughes PJ, Lewis DM, Radfar L, Vista ES, Edgar CE, Rohrer MD, Stone DU, Vyse TJ, Harley JB, Gaffney PM, James JA, Turner S, Alevizos I, Anaya JM, Rhodus NL, Segal BM, Montgomery CG, Scofield RH, Kovats S, Mariette X, Rönnblom L, Witte T, Rischmueller M, Wahren-Herlenius M, Omdal R, Jonsson R, Ng WF; for UK Primary Sjögren's Syndrome Registry, Nordmark G, Lessard CJ, Sivils KL.  Identification of a Sjögren's syndrome susceptibility locus at OAS1 that influences isoform switching, protein expression, and responsiveness to type I interferons. PLoS Genet. 2017 Jun 22;13(6):e1006820.  PMID: 28640813

Molineros JE, Yang W, Zhou XJ, Sun C, Okada Y, Zhang H, Heng Chua K, Lau YL, Kochi Y, Suzuki A, Yamamoto K, Ma J, Bang SY, Lee HS, Kim K, Bae SC, Zhang H, Shen N, Looger LL, Nath SK. Confirmation of five novel susceptibility loci for systemic lupus erythematosus (SLE) and integrated network analysis of 82 SLE susceptibility loci. Hum Mol Genet. 2017 Mar 15;26(6):1205-16. PMID: 28108556

Munroe ME, Vista ES, Merrill JT, Guthridge JM, Roberts VC, James JA. Pathways of impending disease flare in African-American systemic lupus erythematosus patients. J Autoimmun. 2017 Mar;78:70-78. PMCID: PMC5340190

Patel VI, Booth JL, Duggan ES, Cate S, White VL, Hutchings D, Kovats S, Burian DM, Dozmorov M, Metcalf JP. Transcriptional Classification and Functional Characterization of Human Airway Macrophage and Dendritic Cell Subsets. J Immunol. 2017 Feb 1;198(3):1183-1201.  PMCID:PMC5262539

Qi YY, Zhou XJ, Nath SK, Sun C, Wang YN, Hou P, Mu R, Li C, Guo JP, Li ZG, Wang G, Xu HJ, Hao YJ, Zhang ZL, Yue WH, Zhang HR, Zhao MH, Zhang H.  A rare variant (rs933717) at FBXO31-MAP1LC3B in Chinese is associated with systemic lupus erythematosus. Arthritis Rheumatol. 2017 Oct 17.  PMID:29044928

Schell J, Betts NM, Foster M, Scofield RH, Basu A. Cranberries improve postprandial glucose excursions in type 2 diabetes. Food Funct. 2017 Jul 27.   PMID: 28748974

Sharma R, Harris VM, Cavett J, …, Lessard CJ, Harley JB, Ng WF, Rasmussen A, Sivils KL, Scofield RH.  Rare X Chromosome Abnormalities in Systemic Lupus Erythematosus and Sjögren's Syndrome. Arthritis Rheumatol. 2017 Nov;69(11):2187-92. PMID: 28692793

Shirley E, Chakravarty EF. The Herpes Zoster Vaccine in Rheumatic Diseases: Duration of Response. J Rheumatol. 2017 Jul;44(7):968-969.  PMID: 28668813

*Siefert JC, Georgescu C, Wren JD, Koren A, Sansam CL. DNA replication timing during development anticipates transcriptional programs and parallels enhancer activation. Genome Res. 2017 May 16. pii: gr.218602.116.  PMID: 28512193

Stone DU, Fife D, Brown M, Earley KE, Radfar L, Kaufman CE, Lewis DM, Rhodus NL, Segal BM, Wallace DJ, Weisman MH, Venuturupalli S, Brennan MT, Lessard CJ, Montgomery CG, Scofield RH, Sivils KL, Rasmussen A. Effect of Tobacco Smoking on The Clinical, Histopathological, and Serological Manifestations of Sjögren's Syndrome. PLoS One. 2017 Feb 6;12(2):e0170249. PMCID: PMC5293551

*Tipton AR, Wren JD, Daum JR, Siefert JC, Gorbsky GJ.  GTSE1 regulates spindle microtubule dynamics to control Aurora B kinase and Kif4A chromokinesin on chromosome arms. J Cell Biol. 2017 Oct 2;216(10):3117-32. PMCID:PMC5626529

Troyanov Y, Landon-Cardinal O, Fritzler MJ, Ferreira J, Targoff IN, Rich E, Goulet M, Goulet JR, Bourré-Tessier J, Robitaille Y, Drouin J, Albert A, Senécal JL. Atorvastatin-induced necrotizing autoimmune myositis: An emerging dominant entity in patients with autoimmune myositis presenting with a pure polymyositis phenotype. Medicine (Baltimore). 2017 Jan;96(3):e5694. PMCID: PMC5279076

Tung KS, Harakal J, Qiao H, Rival C, Li JC, Paul AG, Wheeler K, Pramoonjago P, Grafer CM, Sun W, Sampson RD, Wong EW, Reddi PP, Deshmukh US, Hardy DM, Tang H, Cheng CY, Goldberg E. Egress of sperm autoantigen from seminiferous tubules maintains systemic tolerance. J Clin Invest. 2017 Mar 1;127(3):1046-60. PMCID: PMC5330742

Unnikrishnan A, Jackson J, Matyi SA, Hadad N, Wronowski B, Georgescu C, Garrett KP, Wren JD, Freeman WM, Richardson A. Role of DNA methylation in the dietary restriction mediated cellular memory. Geroscience. 2017 May 5.  PMID: 28477138

Wang HC, Qian L, Zhao Y, Mengarelli J, Adrianto I, Montgomery CG, Urban JF Jr, Fung KM, Sun XH. Downregulation of E Protein Activity Augments an ILC2 Differentiation Program in the Thymus. J Immunol. 2017 Apr 15;198(8):3149-56.  PMCID: PMC5404348

Zhang YM, Zhou XJ, Nath SK, Sun C, Zhao MH, Zhang H. Evaluation of 10 SLE susceptibility loci in Asian populations, which were initially identified in European populations. Sci Rep. 2017 Jan 27;7:41399.  PMCID: PMC5269754

Zhao J, Ma J, Deng Y, Kelly JA, Kim K, Bang SY, Lee HS, Li QZ, Wakeland EK, Qiu R, Liu M, Guo J, Li Z, Tan W, Rasmussen A, Lessard CJ, Sivils KL, Hahn BH, Grossman JM, Kamen DL, Gilkeson GS, Bae SC, Gaffney PM, Shen N, Tsao BP. A missense variant in NCF1 is associated with susceptibility to multiple autoimmune diseases. Nat Genet. 2017 Mar;49(3):433-37.  E PMID: PMC5400098

 

 

* Indicates publications by more than one department or program.

Arthritis & Clinical Immunology Research Program
Oklahoma Medical Research Foundation
825 NE 13th Street, MS 53
Oklahoma City, OK 73104

Phone: (405) 271-4987
Fax: (405) 271- 7063
Email:  judith-james@omrf.org