Arthritis & Clinical Immunology Research Program
What We Do
The human immune system is critical for protection against infections and cancer, but diseases of the immune system can be devastating. These include allergic responses, immunodeficiencies and immune reactions directed against self, called autoimmunity. Autoimmune diseases afflict at least one in twelve Americans and are a leading cause of disability and early death in young women of child-bearing age. Our mission is to improve the lives of patients through a continuum of basic mechanistic studies, clinical research, industry collaborations and clinical care.
Scientists in Arthritis & Clinical Immunology focus on understanding systemic autoimmunity and deciphering basic immunologic concepts. Our studies address the etiology, pathogenesis and molecular mechanisms of complex human autoimmune diseases, such as systemic lupus erythematosus, Sjögren’s disease, rheumatoid arthritis, inflammatory myositis, multiple sclerosis (MS) and thrombotic thrombocytopenic purpura. Our studies on immune development and mechanisms of immune protection or perturbation have broad impact on immune responses to vaccination or infection.
Our investigators use a wide range of genetic, genomic, proteomic, immunologic and molecular approaches. To facilitate these patient-oriented research activities, some of our scientists are also developing novel methods to mine large datasets and evaluate complex human genetic diseases.
In addition, the Arthritis & Clinical Immunology program houses resources that are essential for many investigators in our program and in the larger autoimmune disease research community. These include the Biorepository Core, Clinical Immunology Laboratory, Myositis Testing Laboratory, Human Antibody Core, Clinical Genomics Center and Phenotyping Core. Many of these cores were established and funded through ongoing federal grants, leveraging equipment purchased and serviced by OMRF. Our investigators also benefit from departmental journal clubs, seminar series, intentional mentorship and collaborative, multi-investigator scientific projects.
Our Scientists
Judith A. James, M.D., Ph.D.OMRF Executive Vice President & Chief Medical Officer, Professor and Program Chair
José Alberola-Ila, M.D., Ph.D.
Umesh Deshmukh, Ph.D.
A. Darise Farris, Ph.D.
Susan Kovats, Ph.D.
Yang Mao-Draayer, M.D., Ph.D.
Joan T. Merrill, M.D.
Swapan K. Nath, Ph.D.
Robert H. “Hal” Scofield, M.D.
Xiao-Hong Sun, Ph.D.
Linda F. Thompson, Ph.D.
Robert Axtell, Ph.D.
Joel Guthridge, Ph.D.
Matlock Jeffries, M.D.
Jacquelyn Gorman, Ph.D.
Rufei Lu, M.D., Ph.D.
Meng Zhao, Ph.D.
Harini Bagavant, Ph.D.
Melissa E. Munroe, M.D., Ph.D.
Kenneth Smith, Ph.D.Multiple Sclerosis Center of Excellence
Gabriel Pardo, M.D.
Chelsea Berkley, M.D.Rheumatology Center of Excellence
Ira N. Targoff, M.D.
Cristina Arriens, M.D., MSCSOur Publications
2025
Horisberger A, Griffith A, Keegan J, Arazi A, Pulford J, Murzin E, Howard K, Hancock B, Fava A, Sasaki T, Ghosh T, Inamo J, Beuschel R, Cao Y, Preisinger K, Gutierrez-Arcelus M, Eisenhaure TM, Guthridge J, Hoover PJ, Dall'Era M, Wofsy D, Kamen DL, Kalunian KC, Furie R, Belmont M, Izmirly P, Clancy R, Hildeman D, Woodle ES, Apruzzese W, McMahon MA, Grossman J, Barnas JL, Payan-Schober F, Ishimori M, Weisman M, Kretzler M, Berthier CC, Hodgin JB, Demeke DS, Putterman C, Brenner MB, Anolik JH, Raychaudhuri S, Hacohen N, James JA, Davidson A, Petri MA, Buyon JP, Diamond B, Zhang F, Lederer JA, Rao DA. Blood immunophenotyping identifies distinct kidney histopathology and outcomes in patients with lupus nephritis. J Clin Invest, 2025 June, PMID: 40536813
Sok SPM, Cheng J, Strucinska K, Popescu NI, Wu L, Ke Q, Kiosses WB, Stanford D, Freeman WM, Matsuzaki S, Lewis TL Jr, Zhao M. P-glycoprotein expression skews mitochondrial dye measurements in T cells. Front Immunol 16:1560104, 2025 June, PMID: 40607427, PMCID: PMC12213397
Liu Y, Gan T, Qi YY, Tan M, Xu LL, Li Y, Liu J, Qu S, Wang L, Chen G, Lv JC, Zhao ZZ, Bi W, Zhang P, Zhao MH, Tan Y, Nath SK, Zhang H, Zhou XJ. Genetic susceptibility to membranous lupus nephritis: a genome-wide association study. Ann Rheum Dis, 2025 June, PMID: 40537343
Ramos-Casals M, Baer AN, Brito-Zerón MDP, Hammitt KM, Bouillot C, Retamozo S, Mackey A, Yarowsky D, Turner B, Blanck J, Fisher BA, Akpek EK, Baldini C, Bootsma H, Bowman SJ, Dörner T, Laing L, Lieberman SM, Mariette X, Pflugfelder SC, Sankar V, Sisó-Almirall A, Tzioufas AG, Anaya JM, Armağan B, Bombardieri M, Carsons S, de Vita S, Fox RI, Gerli R, Giacomelli R, Gottenberg JE, Hernández-Molina G, Jonsson R, Kruize A, Kwok SK, Li X, McCoy SS, Ng WF, Olsson P, Rischmueller M, Saraux A, Scofield RH, Valim V, Vitali C, Vivino F, Wahren-Herlenius M, Moutsopoulos HM, International Task Force on Nomenclature of Sjögren Disease. 2023 International Rome consensus for the nomenclature of Sjögren disease. Nat Rev Rheumatol, 2025 June, PMID: 40494962
Williams AP, Turner S, Chlebicz M, Carter H, Miller RAJ, Allushi B, Roe MM, Mejia LL, Labombarde J, Alberola-Ila J, Kovats S. Cutting edge: Extrinsic and intrinsic sex effects differentially regulate pulmonary ILC2 numbers, phenotype, and function. J Immunol, 2025 June, PMID: 40489769
Brawner CM, Sturdy C, Arbeeva L, Golightly YM, Nelson AE, Jeffries MA. Borderline acceleration in blood epigenetic age of unclear biological importance in knee OA progression: Specimens and data from the Osteoarthritis Initiative and Johnston County Osteoarthritis Project. Osteoarthritis Cartilage, 2025 June, PMID: 40480605
Wiley MM, Radziszewski M, Khatri B, Joachims ML, Tessneer KL, Stolarczyk AM, Yao S, Li J, Pritchett-Frazee C, Johnston AA, Rasmussen A, Anaya JM, Aqrawi LA, Bae SC, Baecklund E, Björk A, Brun JG, Bucher SM, Dand N, Eloranta ML, Engelke F, Forsblad-d'Elia H, Fugmann C, Glenn SB, Gong C, Gottenberg JE, Hammenfors D, Imgenberg-Kreuz J, Jensen JL, Johnsen SJA, Jonsson MV, Kelly JA, Khanam S, Kim K, Kvarnström M, Mandl T, Martín J, Morris DL, Nocturne G, Norheim KB, Olsson P, Palm Ø, Pers JO, Rhodus NL, Sjöwall C, Skarstein K, Taylor KE, Tombleson P, Thorlacius GE, Venuturupalli SR, Vital EM, Wallace DJ, Radfar L, Brennan MT, James JA, Scofield RH, Gaffney PM, Criswell LA, Jonsson R, Appel S, Eriksson P, Bowman SJ, Omdal R, Rönnblom L, Warner BM, Rischmueller M, Witte T, Farris AD, Mariette X, Shiboski CH, Sjögren’s International Collaborative Clinical Alliance (SICCA), Wahren-Herlenius M, Alarcón-Riquelme ME, PRECISESADS Clinical Consortium, Ng WF, UK Primary Sjögren’s Syndrome Registry, Sivils KL, Guthridge JM, Adrianto I, Vyse TJ, Tsao BP, Nordmark G, Lessard CJ. Variants in the DDX6-CXCR5 autoimmune disease risk locus influence the regulatory network in immune cells and salivary gland. Ann Rheum Dis, 2025 May, PMID: 40447495, PMCID: PMC12236377
Allushi B, Chlebicz M, Kumar G, Massey K, Labombarde JG, Turner S, Miller RAJ, Williams AP, Quinn A, Kovats S, Axtell RC. Interferon-β treatment reverses the detrimental effect of B-cell depletion therapy on respiratory virus infection. J Immunol, 2025 May, PMID: 40334083
Tsaliki M, Cavett J, Kurien BT, Bruxvoort C, Lewis VM, Ice JA, Dave D, Khosravani S, Grundahl K, Lessard CJ, Rasmussen A, Sivils KL, Farris AD, Koelsch KA, Scofield RH. A cross-sectional observational study of patients with sicca with salivary autoantibodies defines a potential new phenotype of Sjögren's disease. Ann Rheum Dis, 2025 May, PMID: 40320334
Wagner CA, James JA. Risks and benefits of immunosuppressant withdrawal in systemic lupus erythematosus. Nat Rev Rheumatol, 2025 May, PMID: 40316794
Kurien BT, Ice JA, Wood RA, Pharaoh G, Cavett J, Lewis V, Bhaskaran S, Rasmussen A, Lessard CJ, Farris AD, Sivilis K, Koelsch KA, Van Remmen H, Scofield RH. Mitochondrial dysfunction and fatigue in Sjögren's disease. RMD Open 11, 2025 April, PMID: 40274303, PMCID: PMC12020762
Reidy M, Khan M, Mills EA, Wu Q, Garton J, Draayer DE, Zahoor I, Giri S, Axtell RC, Mao-Draayer Y. New Frontiers in Multiple Sclerosis Treatment: From Targeting Costimulatory Molecules to Bispecific Antibodies. Int J Mol Sci 26, 2025 April, PMID: 40332536, PMCID: PMC12028294
Fox RJ, Cohan S, Mao-Draayer Y, Weinstock-Guttman B, Cruz LA, Arnould S, Cox GM, Bar-Or A. Safety and tolerability of conversion to siponimod from other disease-modifying therapies in patients with advancing forms of relapsing MS: Results from the EXCHANGE study. Mult Scler:13524585251330085, 2025 April, PMID: 40248858
Basu A, Hooyman A, Groven S, Devillez P, Scofield RH, Ebersole JL, Champion A, Izuora K. Strawberries improve insulin resistance and related cardiometabolic markers in adults with prediabetes: a randomized controlled crossover trial. J Nutr, 2025 April, PMID: 40250566
Hatipoglu I, Ainsua-Enrich E, Kadel S, Turner S, Singh S, Kovats S. IRF4-regulated transcriptional and functional heterogeneity of lung-resident CD11b cDC2 subsets during influenza virus infection. J Immunol, 2025 April, PMID: 40209091, PMCID: PMC12123216
Tsou PS, Ali RA, Lu C, Sule G, Carmona-Rivera C, Lucotti S, Ikari Y, Wu Q, Campbell P, Gurrea-Rubio M, Maeda K, Fox SE, Brodie WD, Mattichak MN, Foster C, Tambralli A, Yalavarthi S, Amin MA, Kmetova K, Mazetto Fonseca B, Chong E, Zuo Y, Maile M, Imberti L, Caruso A, Caccuri F, Quaresima V, Sottini A, Kuhns DB, Fink DL, Castagnoli R, Delmonte O, Kenney H, Zhang Y, Magliocco M, Su HC, Notarangelo LD, Zemans RL, Mao-Draayer Y, Matei I, Salvatore M, Lyden DC, Kanthi Y, Kaplan MJ, Knight JS, Fox DA. Soluble CD13 is a potential mediator of neutrophil-induced thrombogenic inflammation in SARS-CoV-2 infection. JCI Insight, 2025 April, PMID: 40168094, PMCID: PMC12128962
Pachman LM, Khojah A, Morgan G, Marin W, James J, Kadri S, Yap KL. Monozygotic twins discordant for juvenile dermatomyositis: clinical, serological and gene expression studies. Pediatr Rheumatol Online J 23:32, 2025 March, PMID: 40140985, PMCID: PMC11938629
Inamo J, Keegan J, Griffith A, Ghosh T, Horisberger A, Howard K, Pulford JF, Murzin E, Hancock B, Dominguez ST, Gurra MG, Gurajala S, Jonsson AH, Seifert JA, Feser ML, Norris JM, Cao Y, Apruzzese W, Bridges SL, Bykerk VP, Goodman S, Donlin LT, Firestein GS, Bathon JM, Hughes LB, Filer A, Pitzalis C, Anolik JH, Moreland L, Hacohen N, Guthridge JM, James JA, Cuda CM, Perlman H, Brenner MB, Raychaudhuri S, Sparks JA, Accelerating Medicines Partnership RA/SLE Network, Holers VM, Deane KD, Lederer J, Rao DA, Zhang F. Deep immunophenotyping reveals circulating activated lymphocytes in individuals at risk for rheumatoid arthritis. J Clin Invest 135, 2025 March, PMID: 40091833, PMCID: PMC11910230
Abboud H, Steingo B, Vargas D, Patel J, Nealon N, Willis MA, Mao-Draayer Y, Khaitov D, Tsai M, Kim A, Pandey K, Levy M, Molazadeh N, Romero RS, Ferayorni L, Gholizadeh S. Satralizumab treatment in patients with AQP4-IgG-seropositive neuromyelitis optica spectrum disorder after rituximab treatment: A case series. J Neuroimmunol 403:578585, 2025 March, PMID: 40132364
Cerqueira JJ, Berthele A, Cree BAC, Filippi M, Pardo G, Pearson OR, Traboulsee A, Ziemssen T, Vollmer T, Bernasconi C, Mandel CR, Kulyk I, Chognot C, Raposo C, Schneble HM, Thanei GA, Incera E, Havrdová EK. Long-Term Treatment With Ocrelizumab in Patients With Early-Stage Relapsing MS: Nine-Year Data From the OPERA Studies Open-Label Extension. Neurology 104:e210142, 2025 February, PMID: 39883906, PMCID: PMC11781784
Zaslavsky ME, Craig E, Michuda JK, Sehgal N, Ram-Mohan N, Lee JY, Nguyen KD, Hoh RA, Pham TD, Röltgen K, Lam B, Parsons ES, Macwana SR, DeJager W, Drapeau EM, Roskin KM, Cunningham-Rundles C, Moody MA, Haynes BF, Goldman JD, Heath JR, Chinthrajah RS, Nadeau KC, Pinsky BA, Blish CA, Hensley SE, Jensen K, Meyer E, Balboni I, Utz PJ, Merrill JT, Guthridge JM, James JA, Yang S, Tibshirani R, Kundaje A, Boyd SD. Disease diagnostics using machine learning of B cell and T cell receptor sequences. Science 387:eadp2407, 2025 February, PMID: 39977494, PMCID: PMC12061481
Scofield RH, Wren JD, Lewis VM. The toll like receptor 7 pathway and the sex bias of systemic lupus erythematosus. Front Immunol 16:1479814, 2025 February, PMID: 40051623, PMCID: PMC11882868
Anderson M, Scofield RH. The "Fixed Period," the Wildfire News, and an Unpublished Manuscript: Osler's Farewell Speech Revisited in Geographical Breadth and Emotional Depth. Am J Med Sci, 2025 February, PMID: 39947325
Yuan X, Qin X, Takemoto K, Zhao J, Sanderson M, Xu X, Zhang Y, Helke KL, Jacobs Wolf B, Guthridge JM, James JA, Zhou X, Assassi S, Feghali-Bostwick C, Wang D, Sun L, Tsao BP. Human hypofunctional NCF1 variants promote pulmonary fibrosis in the bleomycin-induced mouse model and patients with systemic sclerosis via expansion of SPP1( ) monocytes-derived macrophages. Ann Rheum Dis 84:294-306, 2025 February, PMID: 39919902, PMCID: PMC11907366
Merrill JT, Gaudreau MC, D'Silva KM. Reply. Arthritis Rheumatol, 2025 January, PMID: 39953664
Radhakrishna U, Kuracha MR, Hamzavi I, Saiyed N, Prajapati J, Rawal RM, Uppala LV, Damiani G, Ratnamala U, Nath SK. Impaired Molecular Mechanisms Contributing to Chronic Pain in Patients with Hidradenitis Suppurativa: Exploring Potential Biomarkers and Therapeutic Targets. Int J Mol Sci 26, 2025 January, PMID: 39940809, PMCID: PMC11817842
Zahoor I, Nematullah M, Ahmed ME, Fatma M, Sajad M, Ayasolla K, Cerghet M, Palaniyandi S, Ceci V, Carrera G, Buttari F, Centonze D, Mao-Draayer Y, Rattan R, Chiurchiù V, Giri S. Maresin-1 promotes neuroprotection and modulates metabolic and inflammatory responses in disease-associated cell types in preclinical models of Multiple Sclerosis. J Biol Chem:108226, 2025 January, PMID: 39864620, PMCID: PMC11903811
Griffin TM, Komaravolu RK, Lopes EBP, Mehta-D'souza P, Conner T, Kovats T, Kovats S, Allen M, Harris P, Humphrey MB, Welhaven HD, Brahmachary P, June RK. Exercise induces dynamic changes in intra-articular metabolism and inflammation associated with remodeling of the infrapatellar fat pad in mice. Sci Rep 15:2428, 2025 January, PMID: 39827311, PMCID: PMC11743197
Gurrea-Rubio M, Lin F, Wicha MS, Mao-Draayer Y, Fox DA. Ligands of CD6: roles in the pathogenesis and treatment of cancer. Front Immunol 15:1528478, 2025 January, PMID: 39840036, PMCID: PMC11747410
Rallabandi HR, Singh MK, Looger LL, Nath SK. Defining Mechanistic Links Between the Non-Coding Variant rs17673553 in CLEC16A and Lupus Susceptibility. Int J Mol Sci 26, 2025 January, PMID: 39796169, PMCID: PMC11720054
Dyson G, Barrett M, Schlupp L, Prinz E, Hannebut N, Szymczak A, Brawner CM, Jeffries MA. Ketogenic Diet-Associated Worsening of Osteoarthritis Histologic Secerity, Increased Pain Sensitivity and Gut Microbiome Dysbiosis in Mice. ACR Open Rheumatol 7:e11794, 2025 January, PMID: 39853943, PMCID: PMC11760994
2024
Hoover AR, Liu K, Furrer C, Lam SSK, Anderson DW, Zhou Z, Yang J, Wong CF, Medcalf AD, Sun XH, Hode T, Alleruzzo L, Delawder A, Raker J, Abousleiman G, Valerio TI, Sun Y, Papin JF, Li M, Chen WR. N-Dihydrogalactochitosan Drives Conventional and Alternative Activations of STING to Synergize Type I IFN and IL-1β Productions for Antitumor Immunity. Adv Funct Mater 34, 2024 December, PMID: 39896882, PMCID: PMC11784597
Popescu NI, Kluza J, Reidy MA, Duggan E, Lambris JD, Thompson LF, Coggeshall KM. Monocyte uptake of polymeric peptidoglycan is bimodal and governed by complement C3 and C4 opsonins. JCI Insight, 2024 December, PMID: 39656526, PMCID: PMC11790019
Kurien BT, Dave D, Tsaliki M, Quadri SMS, Lewis VM, Scofield RH. Experimental Induction of Anti-Muscarinic Type-3-Receptor Extracellular Loop Antibodies by Immunization with 4-Hydroxy-2-nonenal Modified Ro60 and Unmodified Ro60. Clin Exp Immunol, 2024 December, PMID: 39658078, PMCID: PMC11748001
Thomas DE, Enfrein A, Scofield RH. The first use of "lupus" as a disease. Lupus:9612033241306790, 2024 December, PMID: 39648842
Griffin TM, Lopes EBP, Cortassa D, Batushansky A, Jeffries MA, Makosa D, Jopkiewicz A, Mehta-D'souza P, Komaravolu RK, Kinter MT. Sexually dimorphic metabolic effects of a high fat diet on knee osteoarthritis in mice. Biol Sex Differ 15:103, 2024 December, PMID: 39639386, PMCID: PMC11619521
Gupta N, Carsons SE, Carteron NL, Scofield RH, Lee AS, Thomas DE, Moua T, Ussavarungsi K, Clair EWS, Meehan R, Dunleavy K, Makara M, Hammitt KM. Integrating Patient Advocacy Groups in the Development of Clinical Practice Guidelines. Arthritis Care Res (Hoboken), 2024 November, PMID: 39605233
Askanase AD, D'Cruz D, Kalunian K, Merrill JT, Navarra SV, Cahuzac C, Cornelisse P, Murphy MJ, Strasser DS, Trokan L, Berkani O. Cenerimod, a sphingosine-1-phosphate receptor modulator, versus placebo in patients with moderate-to-severe systemic lupus erythematosus (CARE): an international, double-blind, randomised, placebo-controlled, phase 2 trial. Lancet Rheumatol, 2024 November, PMID: 39586304
Mao-Draayer Y, Bar-Or A, Balashov K, Foley J, Smoot K, Longbrake EE, Robertson D, Mendoza JP, Lewin JB, Everage N, Božin I, Lyons J, Mokliatchouk O, Bame E, Giuliani F. Real-World Safety and Effectiveness of Dimethyl Fumarate in Patients with MS: Results from the ESTEEM Phase 4 and PROCLAIM Phase 3 Studies with a Focus on Older Patients. Adv Ther, 2024 November, PMID: 39570545, PMCID: PMC11782338
Noaiseh G, Deboo A, King JK, Varadhachary A, Sarka G, Goodman BP, Hammitt KM, Frantsve-Hawley J, Fox R, Baker MC, Danielides S, Mandel S, Pavlakis PP, Scofield RH, Wallace DJ, Carteron N, Carsons S. Recommendations for Aligned Nomenclature of Peripheral Nervous System Disorders Across Rheumatology and Neurology. Arthritis Rheumatol, 2024 November, PMID: 39489692, PMCID: PMC11936496
Werth VP, Merrill JT, Furie R, Dörner T, van Vollenhoven R, Lipsky P, Weiswasser M, Korish S, Schafer PH, Stern M, Li S, Delev N. Effect of iberdomide on cutaneous manifestations in systemic lupus erythematosus: a randomized phase 2 clinical trial. J Am Acad Dermatol, 2024 October, PMID: 39461504
Fava A, Wagner CA, James JA. Role of Autoantibodies in Lupus Nephritis: reply. Arthritis Rheumatol, 2024 October, PMID: 39415486, PMCID: PMC11945607
Chu D, Schwartz N, Ampudia J, Guthridge J, James J, Buyon JP, Connelly S, Fung M, Ng CT, Accelerating Medicines Partnership: RA/SLE Network, Fava A, Petri M, Mohan C, Putterman C. Soluble urine activated leukocyte cell adhesion molecule is a strong predictor of lupus nephritis. Rheumatology (Oxford), 2024 October, PMID: 39404817, PMCID: PMC12048083
Yuan X, Qin X, Takemoto K, Zhao J, Sanderson M, Xu X, Zhang Y, Helke KL, Jacobs Wolf B, Guthridge JM, James JA, Zhou X, Assassi S, Feghali-Bostwick C, Wang D, Sun L, Tsao BP. Human hypofunctional NCF1 variants promote pulmonary fibrosis in the bleomycin-induced mouse model and patients with systemic sclerosis via expansion of SPP1( ) monocytes-derived macrophages. Ann Rheum Dis, 2024 September, PMID: 39299725
Huang KT, Wagner LE, Takano T, Lin XX, Bagavant H, Deshmukh U, Yule DI. Dysregulated Ca(2 ) signaling, fluid secretion, and mitochondrial function in a mouse model of early Sjögren's disease. Elife 13, 2024 September, PMID: 39259200, PMCID: PMC11390111
Scofield RH, Lewis VM. Is X chromosome inactivation a cause or effect of SLE? Nat Rev Rheumatol, 2024 September, PMID: 39223392
Cordeiro B, Ahn JJ, Gawde S, Ucciferri C, Alvarez-Sanchez N, Revelo XS, Stickle N, Massey K, Brooks DG, Guthridge JM, Pardo G, Winer DA, Axtell RC, Dunn SE. Obesity intensifies sex-specific interferon signaling to selectively worsen central nervous system autoimmunity in females. Cell Metab, 2024 August, PMID: 39168127, PMCID: PMC11463735
Lawrence S, Scofield RH. Post traumatic stress disorder associated hypothalamic-pituitary-adrenal axis dysregulation and physical illness. Brain Behav Immun Health 41:100849, 2024 August, PMID: 39280087, PMCID: PMC11401111
Sok SPM, Pipkin K, Popescu NI, Reidy M, Li B, Van Remmen H, Kinter M, Sun XH, Fan Z, Zhao M. Gpx4 Regulates Invariant NKT Cell Homeostasis and Function by Preventing Lipid Peroxidation and Ferroptosis. J Immunol, 2024 August, PMID: 39158281, PMCID: PMC11408103
Zahoor I, Pan G, Cerghet M, Elbayoumi T, Mao-Draayer Y, Giri S, Palaniyandi SS. Current understanding of cardiovascular autonomic dysfunction in multiple sclerosis. Heliyon 10:e35753, 2024 August, PMID: 39170118, PMCID: PMC11337049
Casares-Marfil D, Martínez-Bueno M, Borghi MO, Pons-Estel G, PRECISESADS Clinical Consortium, Reales G, Zuo Y, Espinosa G, Radstake T, van den Hoogen LL, Wallace C, Guthridge J, James JA, Cervera R, Luigi Meroni P, Martin J, Knight JS, Alarcón-Riquelme ME, Sawalha AH. A genome-wide association study suggests new susceptibility loci for primary antiphospholipid syndrome. Arthritis Rheumatol, 2024 July, PMID: 38973605, PMCID: PMC11521773
Fava A, Wagner CA, Guthridge CJ, Kheir J, Macwana S, DeJager W, Gross T, Izmirly P, Belmont HM, Diamond B, Davidson A, Utz PJ, Weisman MH, Magder LS, Accelerating Medicines Partnership (AMP) RA/SLE Network, Guthridge JM, Petri M, Buyon J, James JA. Association of autoantibody concentrations and trajectories with lupus nephritis histological features and treatment response. Arthritis Rheumatol, 2024 July, PMID: 38962936, PMCID: PMC11521769
Montgomery TL, Wang Q, Mirza A, Dwyer D, Wu Q, Dowling CA, Martens JWS, Yang J, Krementsov DN, Mao-Draayer Y. Identification of commensal gut microbiota signatures as predictors of clinical severity and disease progression in multiple sclerosis. Sci Rep 14:15292, 2024 July, PMID: 38961134, PMCID: PMC11222390
Gawde S, Siebert N, Ruprecht K, Kumar G, Ko RM, Massey K, Guthridge JM, Mao-Draayer Y, Schindler P, Hastermann M, Pardo G, Paul F, Axtell RC. Serum Proteomics Distinguish Subtypes of NMO Spectrum Disorder and MOG Antibody-Associated Disease and Highlight Effects of B-Cell Depletion. Neurol Neuroimmunol Neuroinflamm 11:e200268, 2024 July, PMID: 38885457, PMCID: PMC11186702
Ippolito GMR, Palanjian RR, Mao-Draayer Y, Capizzano A, Barboglio-Romo P, Clemens JQ, Gupta P, Dunn R, O'Dell D, Daignault-Newton S, Van Til M, Cameron AP, Stoffel JT. A Prospective Observational Study of Posterior Tibial Nerve Stimulation in Multiple Sclerosis. Int Urogynecol J, 2024 June, PMID: 38942931
Merrill JT, Tanaka Y, D'Cruz D, Vila-Rivera K, Siri D, Zeng X, Saxena A, Aringer M, D'Silva KM, Cheng L, Mohamed MF, Siovitz L, Bhatnagar S, Gaudreau MC, Doan TT, Friedman A. Efficacy and Safety of Upadacitinib or Elsubrutinib Alone or in Combination for Systemic Lupus Erythematosus: A Phase 2 Randomized Controlled Trial. Arthritis Rheumatol, 2024 June, PMID: 38923871
Anderson E, Powell M, Yang E, Kar A, Leung TM, Sison C, Steinberg R, Mims R, Choudhury A, Espinosa C, Zelmanovich J, Okoye NC, Choi EJ, Marder G, Narain S, Gregersen PK, Mackay M, Diamond B, Levy T, Zanos TP, Khosroshahi A, Sanz I, Luning Prak ET, Bar-Or A, Merrill J, Arriens C, Pardo G, Guthridge J, James J, Payne A, Utz PJ, Boss JM, Aranow C, Davidson A. Factors associated with immune responses to SARS-CoV-2 vaccination in autoimmune disease individuals. JCI Insight, 2024 June, PMID: 38833310, PMCID: PMC11383356
Papinska JA, Durślewicz J, Bagavant H, Deshmukh US. Deleting Mitochondrial Superoxide Dismutase 2 in Salivary Gland Ductal Epithelial Cells Recapitulates Non-Sjögren's Sicca Syndrome. Int J Mol Sci 25, 2024 May, PMID: 38892170, PMCID: PMC11172772
Morand EF, Pike M, Merrill J, F van Vollenhoven R, Werth VP, Hobar C, Delev N, Shah V, Sharkey B, Wegman T, Catlett I, Banerjee S, Singhal S. Plain Language Summary of the PAISLEY study: deucravacitinib as a treatment for people with systemic lupus erythematosus. Expert Opin Investig Drugs:1-11, 2024 May, PMID: 38807572
Barber MRW, Ugarte-Gil MF, Hanly JG, Urowitz MB, St-Pierre Y, Gordon C, Bae SC, Romero-Diaz J, Sanchez-Guerrero J, Bernatsky S, Wallace DJ, Isenberg DA, Rahman A, Merrill JT, Fortin PR, Gladman DD, Bruce IN, Petri M, Ginzler EM, Dooley MA, Ramsey-Goldman R, Manzi S, Jönsen A, van Vollenhoven RF, Aranow C, Mackay M, Ruiz-Irastorza G, Lim SS, Inanc M, Kalunian KC, Jacobsen S, Peschken CA, Kamen DL, Askanase A, Pons-Estel BA, Cardwell FS, Alarcón GS, Clarke AE. Remission and low disease activity are associated with lower healthcare costs: results from the Systemic Lupus International Collaborating Clinics (SLICC) inception cohort. Ann Rheum Dis, 2024 May, PMID: 38754981
Isola JVV, Hense JD, Osorio CAP, Biswas S, Alberola-Ila J, Ocanas SR, Schneider A, Stout MB. Inflammation, immune cells, and cellular senescence in the aging ovary. Reproduction, 2024 May, PMID: 38744316, PMCID: PMC11301429
Zivadinov R, Bergsland N, Jakimovski D, Weinstock-Guttman B, Lorefice L, Schoonheim MM, Morrow SA, Ann Picone M, Pardo G, Zarif M, Gudesblatt M, Nicholas JA, Smith A, Hunter S, Newman S, AbdelRazek MA, Hoti I, Riolo J, Silva D, Fuchs TA, Dwyer MG, Hb Benedict R. Thalamic atrophy and dysconnectivity are associated with cognitive impairment in a multi-center, clinical routine, real-word study of people with relapsing-remitting multiple sclerosis. Neuroimage Clin 42:103609, 2024 April, PMID: 38718640, PMCID: PMC11098945
Bagavant H, Durslewicz J, Pyclik M, Makuch M, Papinska JA, Deshmukh US. Age-associated B cell infiltration in salivary glands represents a hallmark of Sjögren's-like disease in aging mice. Geroscience, 2024 April, PMID: 38656650, PMCID: PMC11493885
Krustev E, Hanly JG, Chin R, Buhler KA, Urowitz MB, Gordon C, Bae SC, Romero-Diaz J, Sánchez-Guerrero J, Bernatsky S, Wallace DJ, Isenberg D, Rahman A, Merrill JT, Fortin PR, Gladman DD, Bruce IN, Petri MA, Ginzler EM, Dooley MA, Ramsey-Goldman R, Manzi S, Jönsen A, Alarcón GS, van Vollenhoven RF, Aranow C, Mackay M, Ruiz-Irastorza G, Lim S, Inanc M, Kalunian KC, Jacobsen S, Peschken CA, Kamen DL, Askenase A, Buyon J, Fritzler MJ, Clarke AE, Choi MY. Anti-KIF20B autoantibodies are associated with cranial neuropathy in systemic lupus erythematosus. Lupus Sci Med 11, 2024 April, PMID: 38599670, PMCID: PMC11015279
Carlucci PM, Preisinger K, Deonaraine KK, Zaminski D, Dall'Era M, Gold HT, Kalunian K, Fava A, Belmont HM, Wu M, Putterman C, Anolik J, Barnas JL, Furie R, Diamond B, Davidson A, Wofsy D, Kamen D, James JA, Guthridge JM, Apruzzese W, Rao D, Weisman MH, Accelerating Medicines Partnership in RA/SLE Network, Izmirly PM, Buyon J, Petri M. Extrarenal symptoms associate with worse quality of life in patients enrolled in the AMP RA/SLE Lupus Nephritis Network. Rheumatology (Oxford), 2024 March, PMID: 38530774, PMCID: PMC11879353
Huang KT, Wagner LE, Takano T, Lin XX, Bagavant H, Deshmukh U, Yule DI. Dysregulated Ca(2 ) signaling, fluid secretion, and mitochondrial function in a mouse model of early Sjögren's syndrome. bioRxiv, 2024 March, PMID: 38562738, PMCID: PMC10983907
Cross AH, Gelfand JM, Thebault S, Bennett JL, von Büdingen HC, Cameron B, Carruthers R, Edwards K, Fallis R, Gerstein R, Giacomini PS, Greenberg B, Hafler DA, Ionete C, Kaunzner UW, Kodama L, Lock C, Longbrake EE, Musch B, Pardo G, Piehl F, Weber MS, Yuen S, Ziemssen T, Bose G, Freedman MS, Anania VG, Ramesh A, Winger RC, Jia X, Herman A, Harp C, Bar-Or A. Emerging Cerebrospinal Fluid Biomarkers of Disease Activity and Progression in Multiple Sclerosis. JAMA Neurol, 2024 March, PMID: 38466277, PMCID: PMC10928543
Jog NR, Wagner CA, Aberle T, Chakravarty EF, Arriens C, Guthridge JM, James JA. Neutrophils isolated from systemic lupus erythematosus patients exhibit a distinct functional phenotype. Front Immunol 15:1339250, 2024 March, PMID: 38524128, PMCID: PMC10957542
Mytych JS, Pan Z, Lopez-Davis C, Redinger N, Lawrence C, Ziegler J, Popescu NI, James JA, Farris AD. Peptidoglycan from Bacillus anthracis Inhibits Human Macrophage Efferocytosis in Part by Reducing Cell Surface Expression of MERTK and TIM-3. Immunohorizons 8:269-280, 2024 March, PMID: 38517345, PMCID: PMC10985058
Stock AJ, Gonzalez Paredes P, de Almeida LP, Kosanke SD, Chetlur S, Budde H, Wakenight P, Zwingman TA, Rosen ABI, Allenspach EJ, Millen KJ, Buckner JH, Rawlings DJ, Gorman JA. The IFIH1-A946T risk variant promotes diabetes in a sex-dependent manner. Front Immunol 15:1349601, 2024 February, PMID: 38487540, PMCID: PMC10937421
Izmirly PM, Kim MY, Carlucci PM, Preisinger K, Cohen BZ, Deonaraine K, Zaminski D, Dall'Era M, Kalunian K, Fava A, Belmont HM, Wu M, Putterman C, Anolik J, Barnas JL, Diamond B, Davidson A, Wofsy D, Kamen D, James JA, Guthridge JM, Apruzzese W, Rao DA, Weisman MH, Accelerating Medicines Partnership in RA/SLE Network, Petri M, Buyon J, Furie R. Longitudinal patterns and predictors of response to standard-of-care therapy in lupus nephritis: data from the Accelerating Medicines Partnership Lupus Network. Arthritis Res Ther 26:54, 2024 February, PMID: 38378664, PMCID: PMC10877793
Gurrea-Rubio M, Wang Q, Mills EA, Wu Q, Pitt D, Tsou PS, Fox DA, Mao-Draayer Y. Siponimod Attenuates Neuronal Cell Death Triggered by Neuroinflammation via NFκB and Mitochondrial Pathways. Int J Mol Sci 25, 2024 February, PMID: 38473703, PMCID: PMC10931690
Singh MK, Rallabandi HR, Zhou XJ, Qi YY, Zhao ZZ, Gan T, Zhang H, Looger LL, Nath SK. KLF2 enhancer variant rs4808485 increases lupus risk by modulating inflammasome machinery and cellular homoeostasis. Ann Rheum Dis, 2024 February, PMID: 38373841, PMCID: PMC11168881
Fazel-Najafabadi M, Looger LL, Rallabandi HR, Nath SK. A multilayered post-GWAS analysis pipeline defines functional variants and target genes for systemic lupus erythematosus (SLE). Arthritis Rheumatol, 2024 February, PMID: 38369936, PMCID: PMC11213670
Ziaei A, Solomon O, Casper TC, Waltz M, Weinstock-Guttman B, Aaen G, Wheeler Y, Graves J, Benson L, Gorman M, Rensel M, Mar S, Lotze T, Greenberg B, Chitnis T, Waldman AT, Krupp L, James JA, Hart J, Barcellos LF, Waubant E. Gene-environment interactions: Epstein-Barr virus infection and risk of pediatric-onset multiple sclerosis. Mult Scler:13524585231224685, 2024 February, PMID: 38332747, PMCID: PMC11093131
Chakravarty EF, Utset T, Kamen DL, Contreras G, McCune WJ, Aranow C, Kalunian K, Massarotti E, Clowse MEB, Rovin BH, Lim SS, Majithia V, Dall'Era M, Looney RJ, Erkan D, Saxena A, Olsen NJ, Ko K, Guthridge JM, Goldmuntz E, Springer J, D'Aveta C, Keyes-Elstein L, Barry B, Pinckney A, McNamara J, James JA. Mycophenolate mofetil withdrawal in patients with systemic lupus erythematosus: a multicentre, open-label, randomised controlled trial. Lancet Rheumatol, 2024 January, PMID: 38301682, PMCID: PMC10922882
Gurrea-Rubio M, Wu Q, Amin MA, Tsou PS, Campbell PL, Amarista CI, Ikari Y, Brodie WD, Mattichak MN, Muraoka S, Randon PM, Lind ME, Ruth JH, Mao-Draayer Y, Ding S, Shen X, Cooney LA, Lin F, Fox DA. Activation of cytotoxic lymphocytes through CD6 enhances killing of cancer cells. Cancer Immunol Immunother 73:34, 2024 January, PMID: 38280067, PMCID: PMC10821976
Sherman MA, Noroozi Farhadi P, Pak K, Trieu EP, Sarkar K, Targoff IN, Neely ML, Mammen AL, Rider LG, Childhood Myositis Heterogeneity Collaborative Study Group. Myositis-associated autoantibodies in juvenile myositis are associated with refractory disease and mortality. Arthritis Rheumatol, 2024 January, PMID: 38272842, PMCID: PMC11136598
Fava A, Buyon J, Magder L, Hodgin J, Rosenberg A, Demeke DS, Rao DA, Arazi A, Celia AI, Putterman C, Anolik JH, Barnas J, Dall'Era M, Wofsy D, Furie R, Kamen D, Kalunian K, James JA, Guthridge J, Atta MG, Monroy Trujillo J, Fine D, Clancy R, Belmont HM, Izmirly P, Apruzzese W, Goldman D, Berthier CC, Hoover P, Hacohen N, Raychaudhuri S, Davidson A, Diamond B, Accelerating Medicines Partnership in RA/SLE network, Petri M. Urine proteomic signatures of histological class, activity, chronicity, and treatment response in lupus nephritis. JCI Insight 9, 2024 January, PMID: 38258904, PMCID: PMC10906224
Isola JVV, Ocañas SR, Hubbart CR, Ko S, Mondal SA, Hense JD, Carter HNC, Schneider A, Kovats S, Alberola-Ila J, Freeman WM, Stout MB. A single-cell atlas of the aging mouse ovary. Nat Aging, 2024 January, PMID: 38200272, PMCID: PMC10798902
Radhakrishna U, Sadhasivam S, Radhakrishnan R, Forray A, Muvvala SB, Metpally RP, Patel S, Rawal RM, Vishweswaraiah S, Bahado-Singh RO, Nath SK. Placental cytochrome P450 methylomes in infants exposed to prenatal opioids: exploring the effects of neonatal opioid withdrawal syndrome on health horizons. Front Genet 14:1292148, 2024 January, PMID: 38264209, PMCID: PMC10805101
Kurien BT, Scofield RH. Current Trends in Validating Antibody Specificities for ELISpot by Western Blotting. Methods Mol Biol 2768:15-27, 2024 January, PMID: 38502385
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