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Home - Science - Scientist Directory - Sun, Xiao-Hong

Xiao-Hong Sun, Ph.D.

Member
Arthritis & Clinical Immunology Research Program

Lew and Myra Ward Chair in Biomedical Research

Adjunct Professor, Departments of Microbiology & Immunology and Cell Biology, University of Oklahoma Health Sciences Center

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My 101

My lab is focused on a specific family of proteins called E proteins, which are decision makers that control genetic information and decide what kinds of cells are made.

We want to understand how these lineage decisions are made and what the implications of these decisions are in human health.

We know that E proteins are important for making B cells and T cells, which are a types of immune cells, but how this process works is poorly understood.

We are investigating how this complex process works by studying mice who do not have E proteins. We specifically looked at the thymus, a small organ that sits at the top of the chest and exists specifically to train the immune system to recognize what is normal and what is not.

When E proteins were removed from the thymus, we discovered the organ made an entirely different kind of cells in their place: innate lymphoid cells. Innate lymphoid cells trigger an immediate immune response and respond to tissue damage or infections very quickly but are less sophisticated in immunity than B or T cells.

We were the first to show the thymus can make these cells, and we are investigating the biological significance to understand why the thymus has this function and how it contributes to health in mice and, ultimately, in humans.

This has important potential for drug development because innate lymphoid cells, while they do some good things, have been implicated in a number of diseases, including asthma, inflammatory bowel disease and psoriasis.

 

Research

Hematopoiesis is a developmental process where hematopoietic stem cells differentiate into different cell types through a series of lineage decisions, which are largely orchestrated by precise transcriptional programs. The basic helix-loop-helix family of transcriptional regulators includes E proteins encoded by the E2A, HEB and E2-2 genes and their inhibitors called Id proteins (Id1-4). Id proteins dimerize with E proteins and inhibit the DNA binding activity of E proteins. Therefore, the net E protein activity in a cell is determined by the concentration of both E and Id proteins. Work from our laboratory and others have shown that these proteins play important roles in several steps in hematopoiesis. E proteins are indispensable for the development of B and T lymphoid cells whereas Id proteins favor myeloid differentiation. These proteins have also been shown to be important for the maintenance of hematopoietic stem cells.

Recently, we have found that E proteins play crucial roles in suppressing the innate lymphoid fates while ensuring the robust production of B and T cells. Innate lymphoid cells are newly discovered classes of immune cells implicated in a variety of ailments such as asthma and inflammatory bowel diseases. We are interested in understanding how alternations in E protein function regulates the production of these cells, thus affecting the disease activities. The animal models we have collected over the years also offer us excellent opportunities to study the impact of these cells on immunity as well as tumor microenvironments.

Brief CV

Education
Ph.D., Cornell University, Ithaca, New York, 1987

Honors and Awards
1989-1991 Cancer Research Institute Postdoctoral Fellowship
1992-1996 Cancer Research Institute Investigator Award
1994-1998 Irma T. Hirschl Trust Career Scientist Award
2002-2005 S. Graham Smith Distinguished Scientist Award
2012   Elected Fellow of the American Association for the Advancement of Science
2014  J.Donald and Patricia H. Capra Award for Scientific Achievement

Other Activities
Reviewer for Immunity, Nature Genetics and Nature Immunology
Member of Scientific Advisory Committee of the Damon Runyon Cancer Research Foundation
Member of the NIH CMI-A and CMI-B study section

Memberships
American Association for the Advancement of Science
American Association of Immunologists
Society of Chinese Bioscientists in America

Joined OMRF Scientific Staff in 1999

Publications

View more publications

Recent Publications

Bajana S, Thomas K, Georgescu C, Zhao Y, Wren JD, Kovats S, Sun XH. Augmenting E Protein Activity Impairs cDC2 Differentiation at the Pre-cDC Stage. Front Immunol 11:577718, 2020 December, PMID: 33391258, PMCID: PMC7775562

Liu C, Yu S, Jin R, Long Y, Lu S, Song Y, Sun X, Sun XH, Zhang Y. Correlation of the levels of DNA-binding inhibitor Id3 and regulatory T cells with SLE disease severity. J Autoimmun:102498, 2020 June, PMID: 32536579

Berrett H, Qian L, Roman O, Cordova A, Simmons A, Sun XH, Alberola-Ila J. Development of Type 2 Innate Lymphoid Cells Is Selectively Inhibited by Sustained E Protein Activity. Immunohorizons 3:593-605, 2019 December, PMID: 31852728, PMCID: PMC6938226

Selected Publications

Zhang P, Zhao Y, Sun XH. (2013) Notch-Regulated Periphery B Cell Differentiation Involves Suppression of E Protein Function. J Immunol. 191:726-36. PMID: 23752615 PMCID: PMC3702643

Zhao Y, Ling F, Wang HC, Sun XH. (2013) Chronic TLR signaling impairs the long-term repopulating potential of hematopoietic stem cells of wild type but not Id1 deficient mice. PLoS One 8(2):e55552. PMID: 23383338 PMCID: PMC3562238

Liu C, Wang HC, Yu S, Jin R, Tang H, Liu YF, Ge Q, Sun XH, Zhang Y. (2014) Id1 expression promotes T regulatory cell differentiation by facilitating TCR co-stimulation. J Immunol. 193: 663-672. PMID: 24920844 PMCID: PMC4082736

Wu W, Sun XH. (2011) A mechanism underlying Notch-induced and ubiquitin-mediated Jak3 degradation. J Biol Chem. 286:41153-41162. PMID: 21969365PMCID: PMC3308829

Nie L, Zhao Y, Wu W, Yang Y, Wang HC, Sun XH. (2011) Notch-induced Asb2 expression promotes protein ubiquitination by forming non-canonical E3 ligase complexes. Cell Research 21:754-769. PMID: 21119685 PMCID: PMC3085721

Cochrane, SW, Zhao Y, Sun XH. (2009) Balance between Id and E proteins regulates myeloid versus lymphoid lineage decisions. Blood 113:1016-1026. PMID: 18927439 PMCID: PMC2635070

 

Contact

Immunobiology and Cancer Research Program, MS 29
Oklahoma Medical Research Foundation
825 N.E. 13th Street
Oklahoma City, OK 73104

Phone: (405) 271-7103
Fax: (405) 271-7128
E-mail: Xiao-Hong-Sun@omrf.org

Lab Staff

Sandra Bajana, Ph.D.
Associate Staff Scientist

Monica Davis
Laboratory Technician

Aneta Pankow
Research Technician

Martyna Michniowska
Research Trainee (Polish Student Exchange Program)

Ashley Hoover
Affiliate

Anand Srinivasan
Affiliate

Amie Simmons
Executive Assistant

News from the Sun lab

Dr. Sun in the Media

News from the Sun lab

Discovery casts light on workings of the immune system
May 23, 2019

The discovery could lead to new therapeutic approaches to a wide range of illnesses, including asthma, inflammatory bowel disease and psoriasis.

New OMRF grant will study immune cell linked to asthma
August 4, 2016

The role of the new cell is to protect the body from parasitic infection.

OMRF honors scientists, long-time director
April 18, 2014

Dr. Kathy Sivils received the Gaylord Prize for Scientific Achievement.

OMRF welcomes five new board members, names new chairs
May 19, 2010

Anoatubby, Burgess, 3 others join OMRF board of directors

OMRF research could curb infections in the elderly
February 23, 2010

OMRF discovery may help body fight infection, disease

OMRF scientists cast new light on cancer-related genes
August 18, 2009

Findings offer clues about stopping breast cancer, leukemias

OMRF uncovers on-and-off switch for adult stem cells: Discovery holds “a great deal of therapeutic potential” for cancer treatment
October 29, 2007

Scientists at the Oklahoma Medical Research Foundation have discovered a protein that acts as a gas pedal and brake for so-called “adult” stem cells. The findings, which appear in the current issue of the scientific journal Blood, could have important treatment implications for cancer and other life-threatening diseases. “This work has a great deal of […]

OMRF to name new board members, chairs
May 24, 2005

At its annual honors and awards banquet this evening, the Oklahoma Medical Research Foundation will name a pair of scientists as endowed chairs and add two new members to its board of directors. Xiao-Hong Sun, Ph.D., will be installed as the Eli Lilly Distinguished Chair in Biomedical Research, while Gary Gorbsky, Ph.D., will become the […]

OMRF Board Meeting Spring 2002
April 24, 2002

In recognition of her highly regarded immunobiology and leukemia research, the Oklahoma Medical Research Foundation named OMRF investigator Dr. Xiao-Hong Sun its S. Graham Smith Distinguished Scientist at the OMRF Board of Directors biannual meeting Tuesday in Oklahoma City. Also Tuesday, two longtime OMRF board members were named life directors and two distinguished Oklahoma women […]

Dr. Sun in the Media

Researchers find new role for thymus
MuskogeePhoenix.com

Discovery casts light on workings of the immune system
OKNursingTimes.com

Discovery casts light on workings of the immune system
JournalRecord.com

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