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Home - Science - Scientist Directory - Kovats, Susan

Susan Kovats, Ph.D.

Associate Member
Arthritis & Clinical Immunology Research Program

Adjunct Associate Professor, Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center

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My 101

Optimal immunity upon respiratory infection depends on lung-resident immune cells. These cells are the first responders to infectious agents, allergens or tissue damage at the lung barrier. We use murine models and human engineered lung tissue models to understand how these resident immune cells respond to infection by influenza virus and respiratory syncytial virus. This new knowledge will help in vaccine design and to understand differences in neonatal and adult immunity.

We are particularly interested in sex differences in immunity. Women often experience a more severe course of influenza virus infection and make up more than 80 percent of patients with autoimmune disease. Cells in the immune system have sex hormone receptors, places that estrogen and androgen can attach and trigger responses, so we know that sex hormones play a role in the system’s function. Our focus is to determine what that role is and how to apply that knowledge to disease.

By learning more about how sex-related hormones like estrogen and androgen impact the immune response, we hope one day to apply that knowledge to fight autoimmune diseases that preferentially affect women such as lupus and Sjögren’s syndrome.

Research

Tissue-resident cells of the innate immune system are the first responders upon infection or tissue damage at mucosal barrier sites. We use a murine model of influenza virus infection to understand the specific roles of lung resident dendritic cells and innate lymphocytes in antiviral responses. We also work with a tissue-engineered lung model in which human respiratory tract myeloid cells are exposed to respiratory syncytial virus, with the goal of understanding differences in neonatal and adult immunity.  Our newest project will explore mechanisms by which sepsis induced by Gram-positive bacteria leads to immunosuppression.

Females often experience increased morbidity upon influenza virus infection, as well as increased incidence and severity of autoimmune disease and asthma. A major focus of the lab is to understand sex differences in numbers and function of innate type 2 lymphocytes (ILC2s) in homeostasis and upon inflammation. We published that female mice harbor significantly greater numbers of lung ILC2s in homeostasis, and we would like to understand how this sex difference contributes to ILC2 responses during infection and inflammatory disease. Ongoing projects will dissect the molecular basis of the differential regulation of female and male ILC2s by inflammatory stimuli and sex hormones in a model of influenza virus infection. This project also will help us to understand the female predominance of autoimmune disease.

We also seek to understand how lung-resident dendritic cells (DCs) regulate T cell memory responses to influenza virus. Acute respiratory disease caused by influenza viruses is imperfectly mitigated by annual vaccination to select strains. Understanding how DCs regulate resident memory CD8+ T cells will aid the development of vaccines that elicit more universal protection to seasonal and emerging pandemic viruses. Mice lacking lung-resident IRF4-dependent DCs showed defective CD8+ T cell memory responses, and ongoing experiments will investigate IRF4-regulated pathways in DCs that promote T cell memory. Our work suggests that vaccination strategies to harness the function of IRF4-dependent DCs could promote the development of CD8+ resident memory T cells during influenza infection.

Brief CV

Education
B.A., University of California, Berkeley, 1984
Ph.D., University of Wisconsin, Madison, 1991

Honors and Awards
1983 Honor Scholarship, University of California, Berkeley
1984-1985 Wisconsin Alumni Research Foundation Fellowship
1985-1988 National Science Foundation Graduate Fellowship
1989 Scholar, designated by the American Society for Histocompatibility and Immunogenetics
1993-1994 Leukemia Society of America Fellowship
1994-1997 National Research Service Award – individual fellowship
1998-1999 Arthritis National Research Foundation fellow
1999-2004 Arthritis Foundation Investigator Award – Duggan Award
2004-2005 Arthritis National Research Foundation fellow
2020 J. Donald and Patricia Capra Award for Scientific Achievement

Other Activities
Associate Editor, The Journal of Immunology (2001-2005)
Editorial board member, Current Immunology Reviews
Ad-hoc member, NIH special emphasis and CMI-A, CMI-B, LCMI grant review panels
Ad-hoc reviewer for scientific journals
AAI Committee on the Status of Women (2013-2016)
Adjunct Associate Professor, Dept. of Microbiology & Immunology, OUHSC

Memberships
American Association of Immunologists
American Association for the Advancement of Science
Society for Mucosal Immunology
Organization for the Study of Sex Differences

Joined OMRF Scientific Staff in 2005

Publications

View more publications

Recent Publications

Jørgensen TN, Kovats S, Lotter H. Editorial: Effects of Androgens on Immunity to Self and Foreign. Front Immunol 11:630066, 2020 December, PMID: 33408721, PMCID: PMC7779623

Bajana S, Thomas K, Georgescu C, Zhao Y, Wren JD, Kovats S, Sun XH. Augmenting E Protein Activity Impairs cDC2 Differentiation at the Pre-cDC Stage. Front Immunol 11:577718, 2020 December, PMID: 33391258, PMCID: PMC7775562

Ainsua-Enrich E, Hatipoglu I, Kadel S, Turner S, Paul J, Singh S, Bagavant H, Kovats S. IRF4-dependent dendritic cells regulate CD8+ T-cell differentiation and memory responses in influenza infection. Mucosal Immunol, 2019 May, PMID: 31089186, PMCID: PMC6527354

Selected Publications

Kadel S, Ainsua-Enrich E, Hatipoglu I, Turner S, Singh S, Khan S, Kovats S. A major population of functional KLRG1– ILC2s in female lungs contributes to a sex bias in ILC2 numbers. Immunohorizons. 2018 Feb;2(2):74-86. PMID: 29568816 PMCID: PMC5860819

Bajaña S, Turner S, Paul J, Ainsua-Enrich E, Kovats S. IRF4 and IRF8 Act in CD11c+ Cells To Regulate Terminal Differentiation of Lung Tissue Dendritic Cells. J Immunol. 2016 Feb 15;196(4):1666-77. Epub 2016 Jan 8. PMID: 26746189 PMCID: PMC4744567

Kovats S, Turner S, Simmons A, Powe T, Chakravarty E, Alberola-Ila J. West Nile virus-infected human dendritic cells fail to fully activate invariant natural killer T cells. Clin Exp Immunol. 2016 Nov;186(2):214-226. Epub 2016 Sep 22. PMID: 27513522 PMCID: PMC5054575

Kovats S. Estrogen receptors regulate innate immune cells and signaling pathways. Cell Immunol. 2015 Apr;294(2):63-9. PMID: 25682174 PMCID: PMC4380804

Bajaña S, Roach K, Turner S, Paul J, Kovats S. IRF4 promotes cutaneous dendritic cell migration to lymph nodes during homeostasis and inflammation. J Immunol. 2012 Oct 1;189(7):3368-77. PMID: 22933627 PMCID: PMC3448873

Carreras E, Turner S, Frank MB, Knowlton N, Osban J, Centola M, Park CG, Simmons A, Alberola-Ila J, Kovats S. Estrogen receptor signaling promotes dendritic cell differentiation by increasing expression of the transcription factor IRF4. Blood. 2010 Jan 14;115(2):238-46. PMID: 19880499 PMCID: PMC2808152

Contact

Arthritis & Clinical Immunology Research Program, MS 24
Oklahoma Medical Research Foundation
825 N.E. 13th Street
Oklahoma City, OK 73104

Phone: (405) 271-8583
Fax: (405) 271-7063
E-mail: Susan-Kovats@omrf.org

Lab Staff

Mandi Roe, Ph.D.
Postdoctoral Fellow

Sean Turner
Lab Manager

Abigail Wegrzynski
Research Technician

Magdalena Chlebicz
Research Trainee (Polish Student Exchange Program)

News from the Kovats lab

Dr. Kovats in the Media

News from the Kovats lab

Presbyterian Health Foundation awards $4.6 million in new research grants
July 20, 2020

The Presbyterian Health Foundation has awarded nearly $4.6 million in biomedical research grants to OMRF and OUHSC.

Weakened immune system leaves elderly prone to virus
June 2, 2020

According to the Centers for Disease Control and Prevention, 8 out of every 10 Covid-19 deaths in the U.S. have occurred in adults age 65 and older. Why?

OMRF honors scientists, board member
April 21, 2020

OMRF doled out awards at its annual spring board meeting on Tuesday.

Oklahoma researchers win $2.16 million grant to use 3D model to study lung virus
November 27, 2018

RSV is the leading cause of viral bronchiolitis and pneumonia worldwide, infecting more than 50 percent of children in their first year of life and nearly 100 percent by age 2.

Investigating the role of obesity in arthritis
February 21, 2017

Osteoarthritis, or OA, is the most common form of disability in the U.S.

Nerdy Holidays to You: Gift Ideas for Budding Scientists
December 17, 2015

Looking for something special for that whiz kid on your holiday list?

Will record rainfall bring more cases of West Nile?
June 16, 2015

Mosquitoes can transmit up to 1 million viruses in a single bite.

Three new grants bring $5.1 million to OMRF and Oklahoma
October 7, 2014

New funding streams will launch studies in cancer, influenza and lupus.

High school student gets crash course in lupus research
May 1, 2014

Logann Wyatt has a personal interest in autoimmune disease.

OMRF focuses on women’s health
May 14, 2012

Scientists are working year-round on diseases that affect women

OMRF scientists discover clue to link between estrogen and lupus
December 22, 2009

Clues tell why women have lupus more often than men

New OMRF finding could help improve vaccines
September 8, 2009

As a resurgent H1N1 flu virus worries medical professionals and families, more people are looking to vaccines to keep them safe. Now a new discovery by scientists at OMRF could shed light on why vaccines are ineffective in some patients. In a paper published in the current issue of the Journal of Biological Chemistry, OMRF researchers Shikha […]

Four new scientists boost OMRF’s research programs
March 23, 2006

Four scientists from some of the nation’s leading research institutions have joined the faculty of the Oklahoma Medical Research Foundation. The new researchers bring additional strength to OMRF’s research in cancer, genetic disorders and immunology. Susannah Rankin, Ph.D., and Dean Dawson, Ph.D., come to OMRF from Boston, where Rankin studied cell division in the Systems […]

Dr. Kovats in the Media

OKC researchers study virus that threatens infants
NewsOk.com

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