Autoimmune and autoinflammatory disorders are a significant cause of morbidity and mortality worldwide. Complex interactions between multiple genetic and environmental factors are essential for the development of these disorders. Our laboratory is interested in understanding how autoimmune responses are initiated, amplified and how they cause tissue injury and pathology.
Sjögren’s syndrome is a chronic autoimmune disorder responsible for causing severe dry mouth, dry eyes, and fatigue. Our laboratory investigates how non-specific activation of the immune system by viruses and bacteria can lead to the development of Sjögren’s syndrome.
Recently, our laboratory has started working on an inflammatory disorder, Sarcoidosis, that mainly affects the lungs. We are developing experimental model systems to test the efficacy of different therapeutics to treat this enigmatic disorder.
Activation of innate immunity by danger signals emanating from external and internal sources is a crucial first-line defense mechanism. However, excessive and chronic activation of innate immunity can lead to autoinflammatory and autoimmune disorders.
The primary focus of my laboratory is to investigate how innate immune responses contribute to the pathology of Sjogren’s syndrome and Sarcoidosis. Our lab integrates human clinical research with disease-relevant animal model systems to gain in-depth knowledge of disease mechanisms. We feel this is key for developing novel diagnostic and therapeutic strategies to treat autoimmune and autoinflammatory disorders.
For details, please follow the lab website link: http://deshmukh.omrf.org/
M.Sc., University of Poona, Pune, India 1988
Ph.D., Jawaharlal Nehru University, New Delhi, India 1995
Honors and Awards
1993 Young Scientist Award, Indian Immunology Society
1998 Postdoctoral Fellowship, Arthritis Foundation
2007 Young Investigator Award, International Congress in SLE, China
2009 Excellence in Research Award, Dept of Medicine, University of Virginia
2001 Scientist Development Grant, American Heart Association
2017 J. Donald and Patricia Capra Award for Scientific Achievement, Oklahoma Medical Research Foundation, Oklahoma City, OK
Standing Member Oral Dental and Craniofacial Sciences Study Section, NIH (2019-2023)
Associate Editor, Frontiers in Immunology (Autoimmune and Autoinflammatory Disorders)
Program Coordinator for the OMRF BioLabs program (Traineeship for students from Polish Universities)
American Association of Immunologists
Joined OMRF Scientific Staff in 2013
Bagavant H, Cizio K, Araszkiewicz AM, Papinska JA, Garman L, Li C, Pezant N, Drake WP, Montgomery CG, Deshmukh US. Systemic immune response to vimentin and granuloma formation in a model of pulmonary sarcoidosis. J Transl Autoimmun 5:100153, 2022 April, PMID: 35434591, PMCID: PMC9006845
Bagavant H, Araszkiewicz AM, Ingram JK, Cizio K, Merrill JT, Arriens C, Guthridge JM, James JA, Deshmukh US. Immune Response to Enterococcus gallinarum in Lupus Patients Is Associated With a Subset of Lupus-Associated Autoantibodies. Front Immunol 12:635072, 2021 May, PMID: 34122404, PMCID: PMC8193979
Garman L, Pelikan RC, Rasmussen A, Lareau CA, Savoy KA, Deshmukh US, Bagavant H, Levin AM, Daouk S, Drake WP, Montgomery CG. Single Cell Transcriptomics Implicate Novel Monocyte and T Cell Immune Dysregulation in Sarcoidosis. Front Immunol 11:567342, 2020 December, PMID: 33363531, PMCID: PMC7753017
Papinska J, Bagavant H, Gymrek GB, Deshmukh US. Pulmonary Involvement in a Mouse Model of Sjögren's Syndrome Induced by STING Activation. Int J Mol Sci. 2020 Jun 25;21(12):4512. doi:10.3390/ijms21124512. PMID: 32630417, PMCID: PMC7349948.
Allushi B, Bagavant H, Papinska J, Deshmukh US. Hyperglycemia and Salivary Gland Dysfunction in the Non-obese Diabetic Mouse: Caveats for Preclinical Studies in Sjögren's Syndrome. Sci Rep. 2019 Nov 29;9(1):17969. doi: 10.1038/s41598-019-54410-9. PMID: 31784615, PMCID: PMC6884560
Papinska J, Bagavant H, Gmyrek GB, Sroka M, Tummala S, Fitzgerald KA, Deshmukh US. Activation of Stimulator of Interferon Genes (STING) and Sjögren's Syndrome. J Dent Res. 2018 Jul;97(8):893-900. doi: 10.1177/0022034518760855. Epub 2018 Mar 5. PMID: 29505322, PMCID: PMC6728552.
Szczerba BM, Kaplonek P, Wolska N, Podsiadlowska A, Rybakowska PD, Dey P, Rasmussen A, Grundahl K, Hefner KS, Stone DU, Young S, Lewis DM, Radfar L, Scofield RH, Sivils KL, Bagavant H, Deshmukh US. Interaction between innate immunity and Ro52-induced antibody causes Sjögren's syndrome-like disorder in mice. Ann Rheum Dis. 2016 Mar;75(3):617-622. doi: 10.1136/annrheumdis-2014-206297. Epub 2015 Feb 5. PMID: 25906316, PMCID: PMC4526450.
Szczerba BM, Rybakowska PD, Dey P, Payerhin KM, Peck AB, Bagavant H, Deshmukh US. Type I interferon receptor deficiency prevents murine Sjögren's syndrome. J Dent Res 92: 444-449, 2013. PMID: 23533183 PMCID: PMC3627507
News from the Deshmukh lab
When Chip Morgan met the first class of Polish biology students to come to OMRF for a year-long training program in 2013, he couldn’t help but notice something. “They were all women,” says the foundation’s long-time executive vice president and chief operating officer. The next year, the story was the same. Ditto in 2015. “I […]