Systemic Lupus Erythematosus is a systemic autoimmune disease affecting multiple organ systems including the kidney, joints, skin and brain. Renal failure is a major cause of morbidity in Lupus patients. Another autoimmune disease, Sjogren’s syndrome affects the saliva and tear producing glands. A characteristic feature of both these diseases is an immune response to intracellular proteins. I am interested in studying how the immune responses to these self-proteins are initiated; and how this activation of the immune system leads to organ damage.
The immune system is constantly responding to the environment, particularly to microbes present on skin and mucosal surfaces. We are currently investigating whether the microbes in the mouth or the gut can initiate autoimmunity and/or influence the severity of disease. This research into the interactions between the microbiota and the immune system will give us insights into disease mechanisms. It will give us some clues on why some patients develop worse kidney disease in Systemic Lupus Erythematosus or worse salivary gland dysfunction in Sjogren’s Syndrome.
1989 – MBBS – Government Medical College, Nagpur, India
1995 –PhD – National Institute of Immunology, New Delhi, India
Joined OMRF staff in 2013
Garman L, Pelikan RC, Rasmussen A, Lareau CA, Savoy KA, Deshmukh US, Bagavant H, Levin AM, Daouk S, Drake WP, Montgomery CG. Single Cell Transcriptomics Implicate Novel Monocyte and T Cell Immune Dysregulation in Sarcoidosis. Front Immunol 11:567342, 2020 December, PMID: 33363531, PMCID: PMC7753017
Bagavant H, Deshmukh US. Protocols for Experimental Sjögren's Syndrome. Curr Protoc Immunol 131:e114, 2020 December, PMID: 33252847
Bagavant H, Michrowska A, Deshmukh US. The NZB/W F1 mouse model for Sjögren's syndrome: A historical perspective and lessons learned. Autoimmun Rev:102686, 2020 October, PMID: 33131691, PMCID: PMC7781068
Bagavant H, Nandula SR, Kaplonek P, Rybakowska PD, Deshmukh US. Alum, an aluminum-based adjuvant, induces Sjögren's syndrome-like disorder in mice. Clin Exp Rheumatol. 2014 Mar-Apr;32(2):251-5. PubMed PMID: 24739520; PubMed Central PMCID: PMC3990870.
Nackiewicz D, Dey P, Szczerba B, Mohammad S, Kaplan JL, McNamara CA, Deshmukh US, Bagavant H. Inhibitor of differentiation 3, a transcription factor, regulates hyperlipidemia-associated kidney disease. Nephron Exp Nephrol. 2014;126(3):141-7. doi: 10.1159/000362452. PubMed PMID: 24854879; PubMed Central PMCID: PMC4113412.
Scindia Y, Nackiewicz D, Dey P, Szymula A, Bajwa A, Rosin DL, Bolton WK, Okusa MD, Deshmukh U, Bagavant H. Activated CD4+ T cells target mesangial antigens and initiate glomerulonephritis. Nephron Exp Nephrol. 2012;121(1-2):e1-9. doi:10.1159/000342368. PubMed PMID: 23095207; PubMed Central PMCID: PMC3606022.
Bagavant H, Scindia Y, Nackiewicz D, Nandula SR, Doran A, Cutchins A, Oldham S, Deshmukh U, McNamara C. Deficiency of a transcriptional regulator, inhibitor of differentiation 3, induces glomerulonephritis in apolipoprotein E-deficient mice: a model linking hyperlipidemia and renal disease. Am J Pathol. 2011 Aug;179(2):651-60. doi: 10.1016/j.ajpath.2011.04.029. PubMed PMID: 21801865; PubMed Central PMCID: PMC3157169.
Arthritis & Clinical Immunology Research Program, MS 24
Oklahoma Medical Research Foundation
825 N.E. 13th Street
Oklahoma City, OK 73104
Phone: (405) 271-2439