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Home - Science - Scientist Directory - Lessard, Christopher J.

Christopher J. Lessard, Ph.D.

Associate Member
Genes & Human Disease Research Program

Adjunct Associate Professor, Department of Pathology, University of Oklahoma Health Sciences Center

My 101

When the initial draft of the human genome was sequenced and released (2003) to researchers, many scientists thought it would immediately reveal the genetic basis for human disease. We soon realized that the human genome is much more complex than was ever imagined. Since then, technological advances have allowed us to evaluate thousands of genetic variants in large populations and conduct genome-wide association studies to identify which genes predispose a person to a particular disease or trait. More recently, we have entered a new era of affordable, rapid sequencing, which has provided scientists with unparalleled access to the high-quality, informative data needed to unravel the genetic relationships to human disease.

Not all diseases are created equal. Some diseases result from disruptions in a single gene, while others, including autoimmune diseases like lupus and Sjögren’s syndrome, are influenced by multiple genes. In autoimmunity, the immune system mistakenly recognizes self-molecules as foreign, leading to inflammatory processes and tissue damage to organs and worse prognosis if not treated. While the precise causes of autoimmune diseases are not fully known, it is well accepted that most arise from a complex interplay of multiple genetic risk factors and environmental triggers. Genetic studies in these diseases require international collaborations to assemble the large patient and healthy control populations needed to conduct large-scale genome-wide associations studies. To date researchers have identified more than 100 genes in lupus. In contrast, only 15 genes have been identified in Sjögren’s syndrome.  The disparity between Sjögren’s and lupus is largely due to the lack of large, well-characterized patient collections and the later age of disease onset.

My lab studies the genetics of autoimmune-related traits. Our goal is to understand the complex interactions between the elements of the human genome to identify new biomarkers and to develop therapeutics that will ultimately improve the lives of patients affected by these serious autoimmune disorders.

Research

In the post genome-wide association (GWA) era, my lab has been focused on determining the mechanisms by which these associations contribute to disease risk.  Since more than 80% of the variants associated with complex traits are not coding and many of the molecular methods used to determine the functional/causal variant(s) have been low throughput, most risk loci have not been characterized mechanistically.  Many large consortiums have worked to catalog features of the human genome outside of the coding sequence, which has helped us prioritize variants for functional characterization; however, many regulatory elements are cell type and/or context specific.  Thus, these data only provide a selected view of the possible ways a variant may alter genomic regulation.  One major observation made by ENCODE and other groups was that more than 60% of the human genome yields RNA molecules of more than 200bp in length; the functions of which are largely unknown.  However, many of those that have been functionally determined work to regulate transcription both in cis and trans.  Recent work, driven by advances in technology to evaluate single cells, have also opened new avenues into our understanding of cell populations, differentiation, and cell type specific differences between patients and healthy subjects.

The goal of my research is to better understand how regulation of protein coding gene expression is controlled by the non-coding genome, and how genetic variation and long non-coding RNAs can lead to dysregulation.  We use bioinformatics, high throughput genotyping, short and long read sequencing, basic cell biology, biochemistry, and various in vitro cellular models. To date, my research has primarily focused on understanding the genetics of systemic lupus erythematosus and Sjögren’s syndrome. However, more recently, my work has expanded to include neuromyelitis optica (NMO), multiple sclerosis (MS), and rheumatoid arthritis. While all of these diseases have autoimmune phenotypes and established genetic influences, our research is aimed at uncovering how similarities and differences between these traits could synergistically improve our understanding of genomic regulation of the human immune system.

Brief CV

Education
B.Sc., University of Minnesota, Minneapolis, MN, 2000
Ph.D., Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 2010
Postdoctoral Studies, Oklahoma Medical Research Foundation, 2012

Honors and Awards

1999-present Member, Golden Key National Honor Society
2008-2009 Barrett Predoctoral Scholarship Fund Award
2008 Notable Poster Award, American College of Rheumatology Annual Scientific Meeting, San Francisco, CA
2009 Paul Kimmelstiel Graduate Student Award for Excellence in Research and Presentation Skills, Department of Pathology, University of Oklahoma Health Sciences Center
2009 American College of Rheumatology Research and Education Foundation/Abbott Health Professional Graduate Student Research Preceptorship Award
2010 Paul Kimmelstiel Graduate Student Award for Excellence in Research and Presentation Skills, Department of Pathology, OUHSC
2010 Graduate Student Association Award for Outstanding Academic Achievement, OUHSC
2010 Outstanding Graduate Award (for a 4.0 GPA), OUHSC
2010 Notable Poster Award, American College of Rheumatology Annual Scientific Meeting, Atlanta GA
2011-present Visiting Professor, Center for Autoimmune Disease Research (CREA), Universidad Del Rosario, Bogotá, Colombia
2011 OMRF Outstanding Paper Award for FY 2010-2011
2015 Notable Translational Abstract, EULAR 2015 (Rome, Italy)
2016 J. Donald and Patricia Capra Award for Scientific Achievement
2020 European League Against Rheumatism (EULAR) E-Congress Basic Science Abstract Award

Professional Membership
American Society of Human Genetics, 2007-present
American College of Rheumatology, 2016-present
American Academy of Neurology, 2015-2016
 

Joined OMRF Scientific Staff in 2007

Publications

View more publications

Recent Publications

Norheim KB, Imgenberg-Kreuz J, Alexsson A, Johnsen SJA, Bårdsen K, Brun JG, Dehkordi RK, Theander E, Mandl T, Jonsson R, Ng WF, Lessard CJ, Rasmussen A, Sivilis K, Ronnblom L, Omdal R. Genetic variants at the RTP4/MASP1 locus are associated with fatigue in Scandinavian patients with primary Sjögren's syndrome. RMD Open 7, 2021 December, PMID: 34907023, PMCID: PMC8671987

Witas R, Rasmussen A, Scofield RH, Radfar L, Stone DU, Grundahl K, Lewis D, Sivils KL, Lessard CJ, Farris AD, Nguyen CQ. Defective Efferocytosis in a Murine Model of Sjögren's Syndrome Is Mediated by Dysfunctional Mer Tyrosine Kinase Receptor. Int J Mol Sci 22, 2021 September, PMID: 34575873, PMCID: PMC8466327

Oyelakin A, Horeth E, Song EC, Min S, Che M, Marzullo B, Lessard CJ, Rasmussen A, Radfar L, Scofield RH, Lewis DM, Stone DU, Grundahl K, De Rossi SS, Kurago Z, Farris AD, Sivils KL, Sinha S, Kramer JM, Romano RA. Transcriptomic and Network Analysis of Minor Salivary Glands of Patients With Primary Sjögren's Syndrome. Front Immunol 11:606268, 2021 January, PMID: 33488608, PMCID: PMC7821166

Selected Publications

Lessard CJ, Li H, Adrianto I, Ice JA, Rasmussen A, Grundahl KM, Kelly JA, Dozmorov MG, Miceli-Richard C, Bowman S, Lester S, Eriksson P, Eloranta ML, Brun JG, Gøransson LG, Harboe E, Gutheridge JM, Kaufman KM, Kvarnström M, Jazebi H, Graham DSC, Grandits ME, Nazmul-Hossain ANM, Patel K, Adler AJ, Maier-Moore JS, Farris AD, Brennan MT, Lessard JA, Chodosh J, Gopalakrishnan R, Hefner KS, Houston GD, Huang AJW, Hughes PJ, Lewis DM, Radfar L, Rohrer MD, Stone DU, Wren JD, Vyse TJ, Gaffney PM, James JA, Omdal R, Wahren-Herlenius M, Illei GG, Witte T, Jonsson R, Rischmueller M, Rönnblom L, Nordmark G, Ng WF, Mariette X, Anaya JM, Rhodus NL, Segal BM, Scofield RH, Montgomery CG, Harley JB, Sivils KL. Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome. Nat Genet. 2013 Nov;45(11):1284-92. Epub 2013 Oct 6. PMID: 24097067 PMCID: PMC3867192

Li H, Reksten TR, Ice JA, Kelly JA, Adrianto I, Rasmussen A, Wang S, He B, Grundahl KM, Glenn SB, Miceli-Richard C, Bowman S, Lester S, Eriksson P, Eloranta ML, Brun JG, Gøransson LG, Harboe E, Guthridge JM, Kaufman KM, Kvarnström M, Graham DSC, Patel K, Adler AJ, Farris AD, Brennan MT, Chodosh J, Gopalakrishnan R, Weisman MH, Venuturupalli S, Wallace DJ, Heffner KS, Houston GD, Huang AJW, Hughes PJ, Lewis DM, Radfar L, Vista ES, Edgar CE, Rohrer MD, Stone DU, Vyse TJ, Harley JB, Gaffney PM, James JA, Turner S, Alevizos I, Anaya JM, Rhodus NL, Segal BM, Montgomery CG, Scofield RH, Kovats S, Mariette X, Rönnblom L, Witte T, Rischmueller M, Wahren-Herlenius M, Omdal R, Jonsson R, Ng WF, Nordmark G, Lessard CJ*, Sivils KL*. Identification of a Sjögren's syndrome susceptibility locus at OAS1 that influences isoform switching, protein expression, and responsiveness to type I interferons. PLoS Genet. 2017 Jun 22;13(6):e1006820. doi: 10.1371/journal.pgen.1006820. eCollection 2017 Jun. PMID: 28640813 PMCID: PMC5501660 (*co-senior authors).

Zhao J, Ma J, Deng Y, Kelly JA, Kim K, Bang SY, Lee HS, Li QZ, Wakeland EK, Qiu R, Liu M, Guo J, Li Z, Tan W, Rasmussen A, Lessard CJ, Sivils KL, Hahn BH, Grossman JM, Kamen DK, Gilkeson GS, Bae SC, Gaffney PM, Shen N, Tsao BP. A missense variant in NCF1 is associated with susceptibility to multiple autoimmune diseases. Nat Genet, 2017 Mar;49(3):433-437. doi:10.1038/ng.3782. Epub 2017 Jan 30. PMID:28135245, PMCID: PMC5400098

Verstappen GM, Ice JA, Bootsma K, Pringle S, Haacke EA, de Lange K, van der Vries GB, Hickey P, Vissink A, Spijkervet FKL, Lessard CJ, Kroese FGM. Gene expression profiling of epithelium-associated FcRL4+B cells in primary Sjögren's syndrome reveals a pathogenic signature. J Autoimmun. 2020 May;109:102439. doi: 10.1016/j.jaut.2020.102439. Epub 2020 Mar 20. PMID: 32201227, PMCID: PMC7337041.

Adrianto I, Wen F, Templeton A, Wiley G, King JB, Lessard CJ, Bates JS, Hu Y, Kelly JA, Kaufman KM, Gutheridge JM, Alarcón-Riquelme ME, Anaya JM, Bae SC, Bang SY, Boackle SA, Brown EE, Petri MA, Gallant C, Ramsey-Goldman R, Reveille JD, Vila LM, Criswell LA, Edberg CJ, Freedman BI, Gregersen PK, Gilkeson GS, Jacob CO, James JA, Kamen DL, Kimberly RP, Martin J, Merrill JT, Niewold TB, Park SY, Pons-Estel BA, Scofield RH, Stevens AM, Tsao BP, Vyse TJ, Langefeld CD, Harley JB, Moser KL, Webb CF, Humphrey MB, Montgomery CG, Gaffney PM. Association of a functional variant downstream of TNFAIP3 with systemic lupus erythematosus. Nat Genet. 2011 Mar;43(3):253-258. doi: 10.1038/ng.766. Epub 2011 Feb 20. PMID: 21336280, PMCID: PMC3103780

Lessard CJ, Sajuthi S, Zhao J, Kwangwoo K, Ice JA, Li H, Ainsworth H, Rasmussen A, Kelly JA, Marion M, Bang SY, Joo YB, Choi J, Lee HS, Kang YM, Suh CH, Chung WT, Lee SK, Choe JY, Shim SC, Oh JH, Kim YJ, Han BG, Shen N, Howe HS, Wakeland EK, Li QZ, Song YW, Gaffney PM, Alarcón-Riquelme ME, Criswell LA, Jacob CO, Kimberly RP, Vyse TJ, Harley JB, Sivils KL, Bae SC, Langefeld CD, Tsao BP. Identification of a systemic lupus erythematosus risk locus spanning ATG16L2, FCHSD2 and P2RY2 in Koreans. Arthritis Rheumatol. 2016 May;68(5):1197-209. PMID: 26663301 PMCID: PMC4981330. (#authors contributed equally).

Contact

Genes & Human Disease Research Program, MS 57
Oklahoma Medical Research Foundation
825 N.E. 13th Street
Oklahoma City, OK 73104

Phone: (405) 271-2539
Fax: (405) 271-2578
E-mail: chris-lessard@omrf.org

For media inquiries, please contact OMRF’s Office of Public Affairs at news@omrf.org.

Lab Staff

Astrid Rasmussen, M.D., Ph.D.
Research Associate Member

Michelle Joachims, Ph.D.
Staff Scientist

Mandi Wiley, Ph.D.
Associate Staff Scientist

Chuang Li, Ph.D.
Bioinformatics Scientist

Bhuwan Khatri, Ph.D.
Senior Computational Post-Doctoral Fellow

Anna Nagel, Ph.D.
Post-Doctoral Fellow

Kandice Tessneer, Ph.D.
Science Writer Specialist

Kiely Grundahl
Senior Manager of Laboratory

Cherilyn Pritchett Frazee
Research Technician IV

Anna "Ania" Stolarczyk
Research Technician III

Catelyn Jones
Research Technician

Marcin Radziszewski
Research Trainee

Anna Erol
Visiting Graduate Student Trainee

Shelby Thompson
Administrative Assistant III

News from the Lessard lab

Dr. Lessard in the Media

News from the Lessard lab

OMRF receives $3.7 million for autoimmune disease research
October 8, 2020

OMRF scientist Christopher Lessard received a five-year grant to identify genes associated with Sjögren’s syndrome.

OMRF launches new genetics research program
April 1, 2019

The new Genes and Human Disease Research Program will broaden OMRF’s investigation into genetic mechanisms in various diseases.

Researchers identify gene associated with lupus
May 18, 2017

The gene, NCF1, was known by researchers, but it had not previously been linked to lupus

New OMRF grant to investigate rare autoimmune disease
December 8, 2016

OMRF has received $646,000 to study the genetic origins of NMO.

Scientists discover clues about cause of dryness in Sjögren’s syndrome
June 29, 2016

Findings may point researchers to the origins of this autoimmune disease

Does X mark the spot? A new clue why autoimmune diseases target women
June 13, 2016

Gender bias of diseases like lupus and Sjögren’s could be linked X chromosomes.

OMRF adds board member, honors scientists at spring meeting
April 14, 2016

OMRF hosted its annual spring board meeting on Wednesday.

OMRF scientist discovers new multiple sclerosis biomarkers
March 10, 2016

Scientists have discovered subtle biological signs in the development of MS.

Researchers identify genes associated with lupus in Koreans
February 24, 2016

The study looked at genetic samples of nearly 8,000 Koreans.

New grant will investigate overlaps in autoimmune diseases
June 23, 2015

OMRF scientist receives grant for promising Sjögren’s research.

Does DNA determine happiness?
June 20, 2014

Some genes influence joy, but that’s not the whole story.

International coalition finds six new Sjögren’s syndrome genes
October 7, 2013

Researchers have exponentially increased their understanding of Sjögren’s genetics.

OMRF discovers three new lupus genes
March 29, 2012

The international study turns up new targets for lupus research

OMRF leads international team of scientists
January 11, 2011

Nearly 50 scientists at 33 institutions collaborate to pinpoint lupus genes

Dr. Lessard in the Media

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