Autoimmunity Center of Excellence (ACE)

The Oklahoma ACE Program has successfully forged numerous collaborations across scientific disciplines, across medical specialties, and between basic and clinical scientists in the search for effective treatments for autoimmune diseases.

Clinical studies:

• SRA01
• ASJ02 – Studies Baminercept in primary Sjögren’s syndrome; led by Judith A. James, MD, PhD
• ALE06 – Investigates the withdrawal of MMF in suppressed SLE; led by Eliza Chakravarty, MD
• ARA08 – A collaboration with Kevin Deane, MD, PhD and Michael Holers, MD of the University of Colorado to prevent the onset of clinically-apparent rheumatoid arthritis (also known as StopRA)
• ALE09
• AMS04

Mechanistic studies:

• ASJ02 – A collaboration with Duke University that studied the mechanisms of B cell responses in autoimmune disease
• ALE06 – A collaboration with Duke University to determine the mechanisms of B cell responses in autoimmune disease; Directed by Judith A. James, MD, PhD and Joel Guthridge, PhD
• ARA08
• ALE09