Cell Cycle & Cancer Biology Research Program
What We Do
The Cell Cycle & Cancer Biology Research Program focuses on basic biological processes that control cell growth and cell division. Researchers within this program use cutting-edge technologies in molecular biology, genetics, and advanced microscopy to investigate the factors that regulate genome stability in experimental systems such as budding yeast, Xenopus laevis, mouse, zebrafish, and cultured mammalian cells.
The contributions made by members of CCCB in illuminating the normal pathways of cell division and the malfunctions that lead to chromosome abnormalities have important implications for human diseases including birth defects and cancer.
The members of CCCB place strong emphasis on research training of students and postdoctoral fellows.
Our Scientists
Gary J. Gorbsky, Ph.D.
Dean Dawson, Ph.D.
Susannah Rankin, Ph.D.
Roberto Jose Pezza, Ph.D.
Christopher L. Sansam, Ph.D.
Rafal Donczew, Ph.D.
Elizabeth Finn, Ph.D.
Jacob G. Kirkland, Ph.D.Our Publications
2025
Mahendrawada L, Warfield L, Donczew R, Hahn S. Low overlap of transcription factor DNA binding and regulatory targets. Nature, 2025 April, PMID: 40240607
2024
Narozna M, Latham MC, Gorbsky GJ. Origin of Chromosome 12 Trisomy Surge in Human Induced Pluripotent Stem Cells (iPSCs). bioRxiv, 2024 December, PMID: 39677655, PMCID: PMC11642788
Park J, Kirkland JG. The role of the Polybromo-associated BAF complex in development. Biochem Cell Biol, 2024 November, PMID: 39541575, PMCID: PMC11752563
Bergwell M, Park J, Kirkland JG. Differential modulation of polycomb-associated histone marks by cBAF, pBAF, and gBAF complexes. Life Sci Alliance 7, 2024 August, PMID: 39209535, PMCID: PMC11361369
Mian Y, Wang L, Keikhosravi A, Guo K, Misteli T, Arda HE, Finn EH. Cell type- and transcription-independent spatial proximity between enhancers and promoters. Mol Biol Cell:mbcE24020082, 2024 May, PMID: 38717453, PMCID: PMC11244156
Evatt JM, Sadli AD, Rapacz BK, Chuong HH, Meyer RE, Ridenour JB, Donczew R, Dawson DS. Centromere pairing enables correct segregation of meiotic chromosomes. Curr Biol, 2024 April, PMID: 38670094, PMCID: PMC11111343
Rankin BD, Rankin S. The MCM2-7 Complex: Roles beyond DNA Unwinding. Biology (Basel) 13, 2024 April, PMID: 38666870, PMCID: PMC11048021
Noble TD, Sansam CG, Wittig KA, Majchrzycka B, Sansam CL. Cell Cycle-Dependent TICRR/TRESLIN and MTBP Chromatin Binding Mechanisms and Patterns. bioRxiv, 2024 February, PMID: 38370757, PMCID: PMC10871258
Carbajal A, Gryniuk I, de Castro RO, Pezza RJ. Efficient Enrichment of Synchronized Mouse Spermatocytes Suitable for Genome-Wide Analysis. Methods Mol Biol 2818:65-80, 2024 January, PMID: 39126467
de Almeida LP, Lee CY, Carbajal A, de Castro RO, Pezza RJ. Visualization and Quantification of Rapid Chromosome Movements at Early Stages of Mouse Meiosis. Methods Mol Biol 2818:171-177, 2024 January, PMID: 39126474
Chuong HH, Evatt JM, Dawson DS. Dynamic Live Cell Imaging of Budding Yeast Meiosis. Methods Mol Biol 2818:161-169, 2024 January, PMID: 39126473
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Contact Us
Gary J. Gorbsky, Ph.D.
WH and Betty Phelps Chair in Developmental Biology
Chair, Cell Cycle & Cancer Biology
Oklahoma Medical Research Foundation
825 NE 13th Street, MS 48
Oklahoma City, OK 73104
Phone: (405) 271-8168
Fax: (405) 271-7312
Email: gary-gorbsky@omrf.org
