Cell Cycle & Cancer Biology Research Program

The Cell Cycle and Cancer Biology Research Program focuses on basic biological processes that control cell growth and cell division. Researchers within this program use cutting edge technologies in molecular biology, genetics, and advanced microscopy to investigate the factors that regulate genome stability in experimental systems such as budding yeast, Xenopus laevis, mouse,  zebrafish, and cultured mammalian cells.

The contributions made by members of CCCB in illuminating the normal pathways of cell division and the malfunctions that lead to chromosome abnormalities have important implications for human diseases including birth defects and cancer.

The members of CCCB place strong emphasis on research training of students and postdoctoral fellows.

2022

Daum JR, DuBose CO, Sivakumar S, Gorbsky GJ. Live Fluorescence Imaging of Chromosome Segregation in Cultured Cells. Methods Mol Biol 2415:61-86, 2022 January, PMID: 34972946

2021

Tipton AR, Gorbsky GJ. More than Two Populations of Microtubules Comprise the Dynamic Mitotic Spindle. J Cell Sci, 2021 December, PMID: 34907446

Laine LJ, Mäki-Jouppila JHE, Kutvonen E, Tiikkainen P, Nyholm TKM, Tien JF, Umbreit NT, Härmä V, Kallio L, Davis TN, Asbury CL, Poso A, Gorbsky GJ, Kallio MJ. VTT-006, an anti-mitotic compound, binds to the Ndc80 complex and suppresses cancer cell growth in vitro. Oncoscience 8:134-153, 2021 December, PMID: 34926718, PMCID: PMC8667816

Sarkar R, Petrushenko ZM, Dawson DS, Rybenkov VV. Ycs4 Subunit of Saccharomyces cerevisiae Condensin Binds DNA and Modulates the Enzyme Turnover. Biochemistry, 2021 November, PMID: 34723504, PMCID: PMC8668321

Wittig KA, Sansam CG, Noble TD, Goins D, Sansam CL. The CRL4DTL E3 ligase induces degradation of the DNA replication initiation factor TICRR/TRESLIN specifically during S phase. Nucleic Acids Res, 2021 September, PMID: 34534348, PMCID: PMC8501952

Meyer RE, Tipton AR, LaVictoire R, Gorbsky GJ, Dawson DS. Mps1 promotes poleward chromosome movements in meiotic prometaphase. Mol Biol Cell:mbcE20080525T, 2021 March, PMID: 33788584, PMCID: PMC8101486

Gary J. Gorbsky, Ph.D.
WH and Betty Phelps Chair in Developmental Biology
Chair, Cell Cycle and Cancer Biology
Oklahoma Medical Research Foundation
825 NE 13th Street, MS 48
Oklahoma City, OK 73104

Phone: (405) 271-8168
Fax: (405) 271-7312
Email: gary-gorbsky@omrf.org