What We Do
The Cell Cycle and Cancer Biology Research Program focuses on basic biological processes that control cell growth and cell division. Researchers within this program use cutting edge technologies in molecular biology, genetics, and advanced microscopy to investigate the factors that regulate genome stability in experimental systems such as budding yeast, Xenopus laevis, and cultured mammalian cells.
The contributions made by members of CCCB in illuminating the normal pathways of cell division and the malfunctions that lead to chromosome abnormalities have important implications for human diseases including birth defects and cancer.
The members of CCCB place strong emphasis on research training of students and postdoctoral fellows.
da Silva EML, Rankin S. Chromosome Cohesion and Condensation in Xenopus Egg Extracts. Cold Spring Harb Protoc. 2018 Feb 23. PMID:29475994
Guiraldelli MF, Felberg A, Almeida LP, Parikh A, de Castro RO, Pezza RJ. SHOC1 is a ERCC4-(HhH)2-like protein, integral to the formation of crossover recombination intermediates during mammalian meiosis. PLoS Genet. 2018 May 9;14(5):e1007381. May. PMID:29742103
Kurdzo EL, Chuong HH, Evatt JM, Dawson DS. A ZIP1 separation-of-function allele reveals that centromere pairing drives meiotic segregation of achiasmate chromosomes in budding yeast. Kurdzo EL, Chuong HH, Evatt JM, Dawson DS. PLoS Genet. 2018 Aug 9;14(8):e1007513. PMID:30091974
Rankin S. Reconstituting Nuclear and Chromosome Dynamics Using Xenopus Extracts. Cold Spring Harb Protoc. 2018 Aug 27. PMID:30150319
Sansam CG, Pietrzak K, Majchrzycka B, Kerlin MA, Chen J, Rankin S, Sansam CL. A mechanism for epigenetic control of DNA replication. Genes Dev. 2018 Feb 1;32(3-4):224-9. PMID: 29483155
Sapkota H, Wasiak E, Daum JR, Gorbsky GJ. Multiple determinants and consequences of cohesion fatigue in mammalian cells. Mol Biol Cell. 2018 May 30:mbcE18050315. PMID:29846129
Siefert JC, Clowdus EA, Goins D, Koren A, Sansam CL. Profiling DNA Replication Timing Using Zebrafish as an In Vivo Model System. J Vis Exp. 2018 Apr 30;(134). PMID:29757277
* Publications with other research Programs
Gary J. Gorbsky, Ph.D.
WH and Betty Phelps Chair in Developmental Biology
Chair, Cell Cycle and Cancer Biology
Oklahoma Medical Research Foundation
825 NE 13th Street, MS 48
Oklahoma City, OK 73104
Phone: (405) 271-8168
Fax: (405) 271-7312