What We Do
The Cell Cycle and Cancer Biology Research Program focuses on basic biological processes that control cell growth and cell division. Researchers within this program use cutting edge technologies in molecular biology, genetics, and advanced microscopy to investigate the factors that regulate genome stability in experimental systems such as budding yeast, Xenopus laevis, and cultured mammalian cells.
The contributions made by members of CCCB in illuminating the normal pathways of cell division and the malfunctions that lead to chromosome abnormalities have important implications for human diseases including birth defects and cancer.
The members of CCCB place strong emphasis on research training of students and postdoctoral fellows.
Lee CY, Bisig CG, Conrad MM, Ditamo Y, Previato de Almeida L, Dresser ME, Pezza RJ. Extranuclear Structural Components that Mediate Dynamic Chromosome Movements in Yeast Meiosis. Curr Biol, 2020 February, PMID: 32059771, PMCID: PMC7181386
Lee CY, Bisig CG, Conrad MN, Ditamo Y, Previato de Almeida L, Dresser ME, Pezza RJ. Telomere-led meiotic chromosome movements: recent update in structure and function. Nucleus, 2020 May, PMID: 32412326
Sapkota H, Wren JD, Gorbsky GJ. Chondrosarcoma-associated gene 1 (CSAG1) maintains the integrity of the mitotic centrosome in cells with defective p53. J Cell Sci, 2020 April, PMID: 32295846, PMCID: PMC7272337
Bender D, Da Silva EML, Chen J, Poss A, Gawey L, Rulon Z, Rankin S. Multivalent interaction of ESCO2 with the replication machinery is required for sister chromatid cohesion in vertebrates. Proc Natl Acad Sci U S A, 2019 December, PMID: 31879348, PMCID: PMC6969535
Eyster C, Chuong HH, Lee CY, Pezza RJ, Dawson D. The pericentromeric heterochromatin of homologous chromosomes remains associated after centromere pairing dissolves in mouse spermatocyte meiosis. Chromosoma, 2019 June, PMID: 31165256, PMCID: PMC6823320
Hulke ML, Siefert JC, Sansam CL, Koren A. Germline Structural Variations Are Preferential Sites of DNA Replication Timing Plasticity during Development. Genome Biol Evol, 2019 May, PMID: 31076752, PMCID: PMC6582765
Previato de Almeida L, Evatt JM, Chuong HH, Kurdzo EL, Eyster CA, Gladstone MN, Gómez-H L, Llano E, Meyer R, Pendas AM, Pezza RJ, Dawson DS. Shugoshin protects centromere pairing and promotes segregation of nonexchange partner chromosomes in meiosis. Proc Natl Acad Sci U S A 116:9417-9422, 2019 May, PMID: 31019073, PMCID: PMC6511000
Seibert M, Krüger M, Watson NA, Sen O, Daum JR, Slotman JA, Braun T, Houtsmuller AB, Gorbsky GJ, Jacob R, Kracht M, Higgins JMG, Schmitz ML. CDK1-mediated phosphorylation at H2B serine 6 is required for mitotic chromosome segregation. J Cell Biol 218:1164-1181, 2019 April, PMID: 30765437, PMCID: PMC6446833
Gary J. Gorbsky, Ph.D.
WH and Betty Phelps Chair in Developmental Biology
Chair, Cell Cycle and Cancer Biology
Oklahoma Medical Research Foundation
825 NE 13th Street, MS 48
Oklahoma City, OK 73104
Phone: (405) 271-8168
Fax: (405) 271-7312