What We Do
The Cell Cycle and Cancer Biology Research Program focuses on basic biological processes that control cell growth and cell division. Researchers within this program use cutting edge technologies in molecular biology, genetics, and advanced microscopy to investigate the factors that regulate genome stability in experimental systems such as budding yeast, Xenopus laevis, and cultured mammalian cells.
The contributions made by members of CCCB in illuminating the normal pathways of cell division and the malfunctions that lead to chromosome abnormalities have important implications for human diseases including birth defects and cancer.
The members of CCCB place strong emphasis on research training of students and postdoctoral fellows.
Alomer RM, da Silva EML, Chen J, Piekarz KM, McDonald K, Sansam CG, Sansam CL, Rankin S. Esco1 and Esco2 regulate distinct cohesin functions during cell cycle progression. Proc Natl Acad Sci USA. 2017 Sep 12;114(37):9906-11. PMCID: PMC5604028
de Castro RO, Previato L, Goitea V, Felberg A, Guiraldelli MF, Filiberti A, Pezza RJ. The Chromatin-remodeling Subunit Baf200 Promotes Homology-directed DNA Repair and Regulates Distinct Chromatin-remodeling Complexes. J Biol Chem. 2017 May 19;292(20):8459-71. PMCID:PMC5437250
Jordan PW, Eyster C, Chen J, Pezza RJ, Rankin S. Sororin is enriched at the central region of synapsed meiotic chromosomes. Chromosome Res. 2017 Jun;25(2):115-128. PMCID: PMC5441961
Panicker SR, Mehta-D'souza P, Zhang N, Klopocki AG, Shao B, McEver RP. Circulating soluble P-selectin must dimerize to promote inflammation and coagulation in mice. Blood. 2017 May 17. pii: blood-2017-02-770479. [Epub ahead of print] PMID: 28515093
Potapova T, Gorbsky GJ. The Consequences of Chromosome Segregation Errors in Mitosis and Meiosis. Biology (Basel). 2017 Feb 8;6(1). pii: E12. Review. PMCID: PMC5372005
Rao HB, Qiao H, Bhatt SK, Bailey LR, Tran HD, Bourne SL, Qiu W, Deshpande A, Sharma AN, Beebout CJ, Pezza RJ, Hunter N. A SUMO-ubiquitin relay recruits proteasomes to chromosome axes to regulate meiotic recombination. Science. 2017 Jan 27;355(6323):403-7. PMID: 28059716
*Siefert JC, Georgescu C, Wren JD, Koren A, Sansam CL. DNA replication timing during development anticipates transcriptional programs and parallels enhancer activation. Genome Res. 2017 May 16. pii: gr.218602.116. Epub ahead of print. PMID: 28512193
Sivakumar S, Gorbsky GJ. Phosphatase-regulated recruitment of the spindle- and Kinetochore-Associated (Ska) Complex to kinetochores. Biol Open. 2017 Oct 5. pii: bio.026930. PMCID:PMC5703607
*Tipton AR, Wren JD, Daum JR, Siefert JC, Gorbsky GJ. GTSE1 regulates spindle microtubule dynamics to control Aurora B kinase and Kif4A chromokinesin on chromosome arms. J Cell Biol. 2017 Oct 2;216(10):3117-32. PMCID:PMC5626529
* Publications with other research Programs
Gary J. Gorbsky, Ph.D.
WH and Betty Phelps Chair in Developmental Biology
Chair, Cell Cycle and Cancer Biology
Oklahoma Medical Research Foundation
825 NE 13th Street, MS 48
Oklahoma City, OK 73104
Phone: (405) 271-8168
Fax: (405) 271-7312