Endothelial VWF is critical for the pathogenesis of vaso-occlusive episode in a mouse model of sickle cell disease.
Deletion of platelet CLEC-2 decreases GPIba-mediated integrin aIIbb3 activation and decreases thrombosis in TTP.
Heightened activation of embryonic megakaryocytes causes aneurysms in the developing brain of mice lacking podoplanin.
