2025 Scientific Publications

All Publications

Tsaliki M, Cavett J, Kurien BT, Bruxvoort C, Lewis VM, Ice JA, Dave D, Khosravani S, Grundahl K, Lessard CJ, Rasmussen A, Sivils KL, Farris AD, Koelsch KA, Scofield RH. A cross-sectional observational study of patients with sicca with salivary autoantibodies defines a potential new phenotype of Sjögren's disease. Ann Rheum Dis, 2025 May, PMID: 40320334

Wagner CA, James JA. Risks and benefits of immunosuppressant withdrawal in systemic lupus erythematosus. Nat Rev Rheumatol, 2025 May, PMID: 40316794

O'Reilly CL, Davidyan A, Cizio K, Doidge SM, Bubak MP, Borowik AK, Lewis TL Jr, Miller BF. Combining In Vivo 2-Photon Imaging with Photoactivatable Fluorescent Labeling Shows Low Rates of Mitochondrial Dynamics in Skeletal Muscle. Med Sci Sports Exerc, 2025 May, PMID: 40310022

Faakye A, Harold KM, Matsuzaki S, Pranay A, Mendez Garcia MF, Loveland BL, Rigsby SN, Peelor FF 3rd, Eyster C, Miller BF, Griffin TM, Kinter M, Chiao YA, Humphries KM. The effect of enhanced glycolysis on cardiac aging. Geroscience, 2025 May, PMID: 40310487

Woods JP, Rackley A, Kwon HR, Olson LE. PDGFRα signaling regulates cartilage and fibrous tissue differentiation during synovial joint development. Nat Commun 16:4041, 2025 April, PMID: 40301343, PMCID: PMC12041487

Kurien BT, Ice JA, Wood RA, Pharaoh G, Cavett J, Lewis V, Bhaskaran S, Rasmussen A, Lessard CJ, Farris AD, Sivilis K, Koelsch KA, Van Remmen H, Scofield RH. Mitochondrial dysfunction and fatigue in Sjögren's disease. RMD Open 11, 2025 April, PMID: 40274303, PMCID: PMC12020762

Wood TWP, Henriques WS, Cullen HB, Romero M, Blengini CS, Sarathy S, Sorkin J, Bekele H, Jin C, Kim S, Wang X, Laureau R, Chemiakine A, Khondker RC, Isola JVV, Stout MB, Gennarino VA, Mogessie B, Jain D, Schindler K, Suh Y, Wiedenheft B, Berchowitz LE. The retrotransposon-derived capsid genes PNMA1 and PNMA4 maintain reproductive capacity. Nat Aging, 2025 April, PMID: 40263616

Chandrakesan P, Yao J, Qu D, May R, Weygant N, Ge Y, Ali N, Sureban SM, Gude M, Vega K, Bannerman-Menson E, Xia L, Bronze M, An G, Houchen CW. Retraction Note: Dclk1, a tumor stem cell marker, regulates pro-survival signaling and self-renewal of intestinal tumor cells. Mol Cancer 24:120, 2025 April, PMID: 40253332, PMCID: PMC12008944

Fox RJ, Cohan S, Mao-Draayer Y, Weinstock-Guttman B, Cruz LA, Arnould S, Cox GM, Bar-Or A. Safety and tolerability of conversion to siponimod from other disease-modifying therapies in patients with advancing forms of relapsing MS: Results from the EXCHANGE study. Mult Scler:13524585251330085, 2025 April, PMID: 40248858

Mahendrawada L, Warfield L, Donczew R, Hahn S. Low overlap of transcription factor DNA binding and regulatory targets. Nature, 2025 April, PMID: 40240607

Basu A, Hooyman A, Groven S, Devillez P, Scofield RH, Ebersole JL, Champion A, Izuora K. Strawberries improve insulin resistance and related cardiometabolic markers in adults with prediabetes: a randomized controlled crossover trial. J Nutr, 2025 April, PMID: 40250566

Efthymiou S, Leo CP, Deng C, Lin SJ, Maroofian R, Lin R, Karagoz I, Zhang K, Kaiyrzhanov R, Scardamaglia A, Owrang D, Turchetti V, Jahnke F, Huang K, Petree C, Derrick AV, Rees MI, Alvi JR, Sultan T, Li C, Jacquemont ML, Tran-Mau-Them F, Valenzuela-Palafoll M, Sidlow R, Yoon G, Morrow MM, Carere DA, O'Connor M, Fleischer J, Gerkes EH, Phornphutkul C, Isidor B, Rivier-Ringenbach C, Philippe C, Kurul SH, Soydemir D, Kara B, Sunnetci-Akkoyunlu D, Bothe V, Platzer K, Wieczorek D, Koch-Hogrebe M, Rahner N, Thuresson AC, Matsson H, Frykholm C, Bozdoğan ST, Bisgin A, Chatron N, Lesca G, Cabet S, Tümer Z, Hjortshøj TD, Rønde G, Marquardt T, Reunert J, Afzal E, Zamani M, Azizimalamiri R, Galehdari H, Nourbakhsh P, Chamanrou N, Chung SK, Suri M, Benke PJ, Zaki MS, Gleeson JG, Calame DG, Pehlivan D, Yilmaz HI, Gezdirici A, Rad A, Abumansour IS, Oprea G, Bereketoğlu MB, Banneau G, Julia S, Zeighami J, Ashoori S, Shariati G, Sedaghat A, Sabri A, Hamid M, Parvas S, Tajudin TA, Abdullah U, Baig SM, Chung WK, Glazunova OO, Sabine S, Cheema HA, Zifarelli G, Bauer P, Sidpra J, Mankad K, Vona B, Fry AE, Varshney GK, Houlden H, Fu D. Biallelic pathogenic variants in TRMT1 disrupt tRNA modification and induce a neurodevelopmental disorder. Am J Hum Genet, 2025 April, PMID: 40245862

Sharpe AL, Liter LR, Donohue D, Carter KA, Vangeneugden P, Weaver SM, Stout MB, Beckstead MJ. Aged mice exhibit faster acquisition of intravenous opioid self-administration with variable effects on intake. Neuropharmacology:110464, 2025 April, PMID: 40228626

Hatipoglu I, Ainsua-Enrich E, Kadel S, Turner S, Singh S, Kovats S. IRF4-regulated transcriptional and functional heterogeneity of lung-resident CD11b cDC2 subsets during influenza virus infection. J Immunol, 2025 April, PMID: 40209091

Nyul-Toth A, Shanmugarama S, Patai R, Gulej R, Faakye J, Nagy D, Nagykaldi M, Kiss T, Csipo T, Milan M, Ekambaram S, Negri S, Nagaraja RY, Csiszar A, Brown JL, Van Remmen H, Ungvari A, Yabluchanskiy A, Tarantini S, Ungvari Z. Endothelial IGF- 1R deficiency disrupts microvascular homeostasis, impairing skeletal muscle perfusion and endurance: implications for age-related sarcopenia. Geroscience, 2025 April, PMID: 40199795

Kobak KA, Zarzycka W, King CJ, Borowik AK, Peelor FF 3rd, Baehr LM, Leutert M, Rodriguez-Mias RA, Villén J, Bodine SC, Kinter MT, Miller BF, Chiao YA. Proteostatic Imbalance Drives the Pathogenesis and Age-Related Exacerbation of Heart Failure With Preserved Ejection Fraction. JACC Basic Transl Sci 10:475-497, 2025 April, PMID: 40306856

Tsou PS, Ali RA, Lu C, Sule G, Carmona-Rivera C, Lucotti S, Ikari Y, Wu Q, Campbell P, Gurrea-Rubio M, Maeda K, Fox SE, Brodie WD, Mattichak MN, Foster C, Tambralli A, Yalavarthi S, Amin MA, Kmetova K, Mazetto Fonseca B, Chong E, Zuo Y, Maile M, Imberti L, Caruso A, Caccuri F, Quaresima V, Sottini A, Kuhns DB, Fink DL, Castagnoli R, Delmonte O, Kenney H, Zhang Y, Magliocco M, Su HC, Notarangelo LD, Zemans RL, Mao-Draayer Y, Matei I, Salvatore M, Lyden DC, Kanthi Y, Kaplan MJ, Knight JS, Fox DA. Soluble CD13 is a potential mediator of neutrophil-induced thrombogenic inflammation in SARS-CoV-2 infection. JCI Insight, 2025 April, PMID: 40168094

Pachman LM, Khojah A, Morgan G, Marin W, James J, Kadri S, Yap KL. Monozygotic twins discordant for juvenile dermatomyositis: clinical, serological and gene expression studies. Pediatr Rheumatol Online J 23:32, 2025 March, PMID: 40140985, PMCID: PMC11938629

Rajala R, Griffin CT. A novel function for endothelial protease-activated receptors in modulating insulin receptor activity with implications for diabetes. bioRxiv, 2025 March, PMID: 40196641, PMCID: PMC11974755

Myers JM, Sandel C, Alvarez K, Garman L, Wiley G, Montgomery C, Gaffney P, Stavrakis S, Fairweather D, Bruno KA, Zhao YD, Cooper LT, Cunningham MW. Cardiac autoantibodies promote a fibrotic transcriptome and reduced ventricular recovery in human myocarditis. Front Immunol 16:1500909, 2025 March, PMID: 40181955, PMCID: PMC11965655

Inamo J, Keegan J, Griffith A, Ghosh T, Horisberger A, Howard K, Pulford JF, Murzin E, Hancock B, Dominguez ST, Gurra MG, Gurajala S, Jonsson AH, Seifert JA, Feser ML, Norris JM, Cao Y, Apruzzese W, Bridges SL, Bykerk VP, Goodman S, Donlin LT, Firestein GS, Bathon JM, Hughes LB, Filer A, Pitzalis C, Anolik JH, Moreland L, Hacohen N, Guthridge JM, James JA, Cuda CM, Perlman H, Brenner MB, Raychaudhuri S, Sparks JA, Accelerating Medicines Partnership RA/SLE Network, Holers VM, Deane KD, Lederer J, Rao DA, Zhang F. Deep immunophenotyping reveals circulating activated lymphocytes in individuals at risk for rheumatoid arthritis. J Clin Invest 135, 2025 March, PMID: 40091833, PMCID: PMC11910230

Abboud H, Steingo B, Vargas D, Patel J, Nealon N, Willis MA, Mao-Draayer Y, Khaitov D, Tsai M, Kim A, Pandey K, Levy M, Molazadeh N, Romero RS, Ferayorni L, Gholizadeh S. Satralizumab treatment in patients with AQP4-IgG-seropositive neuromyelitis optica spectrum disorder after rituximab treatment: A case series. J Neuroimmunol 403:578585, 2025 March, PMID: 40132364

Murach KA, Englund DA, Chambers TL, Dungan CM, Porter HL, Wren JD, Freeman WM, Dupont-Versteegden EE, Wen Y. A satellite cell-dependent epigenetic fingerprint in skeletal muscle identity genes after lifelong physical activity. FASEB J 39:e70435, 2025 March, PMID: 40047419, PMCID: PMC11884312

Burge KY, Georgescu C, Zhong H, Wilson AP, Gunasekaran A, Yu Z, Franca A, Eckert JV, Wren JD, Chaaban H. Spatial transcriptomics delineates potential differences in intestinal phenotypes of cardiac and classical necrotizing enterocolitis. iScience 28:112166, 2025 March, PMID: 40201118, PMCID: PMC11978348

Lin SJ, Huang K, Petree C, Qin W, Varshney P, Varshney GK. Optimizing gRNA selection for high-penetrance F0 CRISPR screening for interrogating disease gene function. Nucleic Acids Res 53, 2025 February, PMID: 40103232, PMCID: PMC11915512

Cerqueira JJ, Berthele A, Cree BAC, Filippi M, Pardo G, Pearson OR, Traboulsee A, Ziemssen T, Vollmer T, Bernasconi C, Mandel CR, Kulyk I, Chognot C, Raposo C, Schneble HM, Thanei GA, Incera E, Havrdová EK. Long-Term Treatment With Ocrelizumab in Patients With Early-Stage Relapsing MS: Nine-Year Data From the OPERA Studies Open-Label Extension. Neurology 104:e210142, 2025 February, PMID: 39883906, PMCID: PMC11781784

Wu C, Chen D, Stout MB, Wu M, Wang S. Hallmarks of ovarian aging. Trends Endocrinol Metab, 2025 February, PMID: 40000274

Zaslavsky ME, Craig E, Michuda JK, Sehgal N, Ram-Mohan N, Lee JY, Nguyen KD, Hoh RA, Pham TD, Röltgen K, Lam B, Parsons ES, Macwana SR, DeJager W, Drapeau EM, Roskin KM, Cunningham-Rundles C, Moody MA, Haynes BF, Goldman JD, Heath JR, Chinthrajah RS, Nadeau KC, Pinsky BA, Blish CA, Hensley SE, Jensen K, Meyer E, Balboni I, Utz PJ, Merrill JT, Guthridge JM, James JA, Yang S, Tibshirani R, Kundaje A, Boyd SD. Disease diagnostics using machine learning of B cell and T cell receptor sequences. Science 387:eadp2407, 2025 February, PMID: 39977494

Gui H, Lessard CJ, Liu J, Li M, Adrianto I. Editorial: Integrative genetics and multi-omics of complex human disorders. Front Genet 16:1574431, 2025 February, PMID: 40061127, PMCID: PMC11885495

Scofield RH, Wren JD, Lewis VM. The toll like receptor 7 pathway and the sex bias of systemic lupus erythematosus. Front Immunol 16:1479814, 2025 February, PMID: 40051623, PMCID: PMC11882868

Anderson M, Scofield RH. The "Fixed Period," the Wildfire News, and an Unpublished Manuscript: Osler's Farewell Speech Revisited in Geographical Breadth and Emotional Depth. Am J Med Sci, 2025 February, PMID: 39947325

Rajala R, Griffin CT. Kinome profiling: A veritable Rosetta stone for protease-activated receptor 1 biased signaling. Vascul Pharmacol:107469, 2025 February, PMID: 39904417, PMCID: PMC11890924

Yuan X, Qin X, Takemoto K, Zhao J, Sanderson M, Xu X, Zhang Y, Helke KL, Jacobs Wolf B, Guthridge JM, James JA, Zhou X, Assassi S, Feghali-Bostwick C, Wang D, Sun L, Tsao BP. Human hypofunctional NCF1 variants promote pulmonary fibrosis in the bleomycin-induced mouse model and patients with systemic sclerosis via expansion of SPP1( ) monocytes-derived macrophages. Ann Rheum Dis 84:294-306, 2025 February, PMID: 39919902, PMCID: PMC11907366

Drumond-Bock AL, Beckstead MJ. Ketones on the Brain: Can Diet Help Turn the Tables on Parkinson's?-Commentary on Mahajan et al. (2024). Eur J Neurosci 61:e70025, 2025 February, PMID: 39937087

Sklivas AB, Hettinger ZR, Rose S, Mantuano A, Confides AL, Rigsby S, Peelor FF 3rd, Miller BF, Butterfield TA, Dupont-Versteegden EE. Responses of skeletal muscle to mechanical stimuli in female rats following and during muscle disuse atrophy. J Appl Physiol (1985), 2025 January, PMID: 39884317

Rajala R, Griffin CT. Endothelial protease-activated receptor 4: impotent or important? Front Cardiovasc Med 12:1541879, 2025 January, PMID: 39935714, PMCID: PMC11810968

Merrill JT, Gaudreau MC, D'Silva KM. Reply. Arthritis Rheumatol, 2025 January, PMID: 39953664

Radhakrishna U, Kuracha MR, Hamzavi I, Saiyed N, Prajapati J, Rawal RM, Uppala LV, Damiani G, Ratnamala U, Nath SK. Impaired Molecular Mechanisms Contributing to Chronic Pain in Patients with Hidradenitis Suppurativa: Exploring Potential Biomarkers and Therapeutic Targets. Int J Mol Sci 26, 2025 January, PMID: 39940809, PMCID: PMC11817842

Zahoor I, Nematullah M, Ahmed ME, Fatma M, Sajad M, Ayasolla K, Cerghet M, Palaniyandi S, Ceci V, Carrera G, Buttari F, Centonze D, Mao-Draayer Y, Rattan R, Chiurchiù V, Giri S. Maresin-1 promotes neuroprotection and modulates metabolic and inflammatory responses in disease-associated cell types in preclinical models of Multiple Sclerosis. J Biol Chem:108226, 2025 January, PMID: 39864620, PMCID: PMC11903811

Tang W, Wang K, Feng Y, Tsui KH, Singh KK, Stout MB, Wang S, Wu M. Exploration of the mechanism and therapy of ovarian aging by targeting cellular senescence. Life Med 4:lnaf004, 2025 January, PMID: 40110109, PMCID: PMC11916902

Griffin TM, Komaravolu RK, Lopes EBP, Mehta-D'souza P, Conner T, Kovats T, Kovats S, Allen M, Harris P, Humphrey MB, Welhaven HD, Brahmachary P, June RK. Exercise induces dynamic changes in intra-articular metabolism and inflammation associated with remodeling of the infrapatellar fat pad in mice. Sci Rep 15:2428, 2025 January, PMID: 39827311, PMCID: PMC11743197

Brown JL, Xu H, Duggan E, Rosenfeld CS, Van Remmen H. Pharmacological reduction of lipid hydroperoxides as a potential modulator of sarcopenia. J Physiol, 2025 January, PMID: 39777675, PMCID: PMC12042244

Laumonnerie C, Shamambo M, Stabley DR, Lewis TL Jr, Trivedi N, Howell D, Solecki DJ. Siah2 antagonism of Pard3/JamC modulates Ntn1-Dcc signaling to regulate cerebellar granule neuron germinal zone exit. Nat Commun 16:355, 2025 January, PMID: 39774925, PMCID: PMC11706986

Strucinska K, Kneis P, Pennington T, Cizio K, Szybowska P, Morgan A, Weertman J, Lewis TL Jr. Fis1 is required for the development of the dendritic mitochondrial network in pyramidal cortical neurons. bioRxiv, 2025 January, PMID: 39829888, PMCID: PMC11741399

Gurrea-Rubio M, Lin F, Wicha MS, Mao-Draayer Y, Fox DA. Ligands of CD6: roles in the pathogenesis and treatment of cancer. Front Immunol 15:1528478, 2025 January, PMID: 39840036, PMCID: PMC11747410

Plafker KS, Georgescu C, Pezant N, Pranay A, Plafker SM. Sulforaphane acutely activates multiple starvation response pathways. Front Nutr 11:1485466, 2025 January, PMID: 39867556, PMCID: PMC11758633

Rallabandi HR, Singh MK, Looger LL, Nath SK. Defining Mechanistic Links Between the Non-Coding Variant rs17673553 in CLEC16A and Lupus Susceptibility. Int J Mol Sci 26, 2025 January, PMID: 39796169, PMCID: PMC11720054

Dyson G, Barrett M, Schlupp L, Prinz E, Hannebut N, Szymczak A, Brawner CM, Jeffries MA. Ketogenic Diet-Associated Worsening of Osteoarthritis Histologic Secerity, Increased Pain Sensitivity and Gut Microbiome Dysbiosis in Mice. ACR Open Rheumatol 7:e11794, 2025 January, PMID: 39853943, PMCID: PMC11760994

De Kumar B, Krishnan J. Guidelines to Analyze ChIP-Seq Data: Journey Through QC and Analysis Considerations. Methods Mol Biol 2889:193-206, 2025 January, PMID: 39745614