2025 Scientific Publications

All Publications

Hoover PJ, Raparia C, Lieb DJ, Tzur Y, Kang J, Arazi A, Leavitt R, Mishra R, Shah SI, Simmons D, Li S, Peters M, Eisenhaure T, Few-Cooper TJ, Gurajala SS, Sonny A, Hodgin JB, Berthier CC, Guthridge JM, Fava A, Clancy RM, Putterman C, Izmirly PM, Belmont HM, Kalunian K, Kamen D, Wofsy D, Buyon JP, James JA, Petri M, Diamond B, Raychaudhuri S, Shen-Orr SS, Accelerating Medicines Partnership in RA/SLE network, Hacohen N, Davidson A. A human-mouse atlas of intrarenal myeloid cells identifies conserved disease-associated macrophages in lupus nephritis. J Exp Med 222, 2025 November, PMID: 40900124

Narozna M, Latham MC, Gorbsky GJ. Origin of chromosome 12 trisomy surge in human induced pluripotent stem cells. J Cell Biol 224, 2025 November, PMID: 40801878

Thakolwiboon S, Redenbaugh V, Chen B, Hewitt S, Shah S, Lotan I, Levy M, Forcadela M, Huda S, Pique J, Marignier R, Boutiere C, Audoin B, Poullin P, Champsas D, Choi D, Danesh-Meyer HV, Vasileiou E, Sotirchos ES, Davis JB, Henderson AD, Wilf-Yarkoni A, Stiebel-Kalish H, Maillart E, Bonelli L, Arnold AC, Boudot De La Motte M, Deschamps R, Jitprapaikulsan J, Moss HE, Villarreal Navarro SE, Mao-Draayer Y, Mishra M, Vorasoot N, Cacciaguerra L, Tisavipat N, Tajfirouz DA, Tillema JM, Lopez-Chiriboga SA, Palace J, Hacohen Y, Pittock SJ, Flanagan EP, Chen JJ. Outcomes After Acute Plasma Exchange for Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease. Neurology 105:e213903, 2025 September, PMID: 40882166

Olsen NJ, Liao D, James JA, Guthridge JM, Arriens C, Kamen D, Ishimori M, Wallace DJ, Striebich C, Narain S, Chong BF, He F, Schaefer EW, Chinchilli VM, Karp DR. A randomized, placebo-controlled trial of hydroxychloroquine in incomplete lupus. Arthritis Rheumatol, 2025 September, PMID: 40955637

Negri S, Nyul-Toth A, Milan M, Troyano-Rodriguez E, Tavakol S, Ihuoma J, Reyff Z, Rudraboina R, Gulej R, Jang R, Csiszar A, Ungvari Z, Cleuren A, Miller DR, Yabluchanskiy A, Tanter M, Tarantini S. A Minimally Invasive Framework Reveals Region-Specific Cerebrovascular Remodeling in Aging Using Intravital Functional Ultrasound Imaging and Ultrasound Localization Microscopy (fUS-ULM). Adv Sci (Weinh):e10754, 2025 September, PMID: 40946188

Arriens C, Morand EF, Askanase AD, Furie R, van Vollenhoven RF, Tanaka Y, Connors K, Davey M, Young K, Franchin G, Meier R, Shah V, de Oliveria CL, Hobar C. Design of Two Randomized, Placebo-Controlled, Phase 3 Trials of Deucravacitinib, an Oral, Selective, Allosteric TYK2 Inhibitor, in Systemic Lupus Erythematosus. Adv Ther, 2025 September, PMID: 40920289

Geng X, Chen L, Ahmed Z, Formigari GP, Ho YC, Del Gaudio I, Datilo MN, Azartash-Namin ZJ, Heron C, Shan X, Keshari RS, Pal S, Chen H, Lupu F, Xia L, Randolph GJ, Zawieja SD, Camerer E, Davis MJ, Srinivasan RS. S1PR1 regulates lymphatic valve development and tertiary lymphoid organ formation in the ileum. J Exp Med 222, 2025 September, PMID: 40553105, PMCID: PMC12187108

Li R, Gagliano Taliun SA, Liao K, Flickinger M, Sobell JL, Genovese G, Locke AE, Chiu RR, LeFaive J, Wang J, Martins T, Chapman S, Neumann A, Handsaker RE, Arnett DK, Barnes KC, Boerwinkle E, Braff D, Cade BE, Fornage M, Gibbs RA, Hoth KF, Hou L, Kooperberg C, Loos RJF, Metcalf GA, Montgomery CG, Morrison AC, Qin ZS, Redline S, Reiner AP, Rich SS, Rotter JI, Taylor KD, Viaud-Martinez KA, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Genomic Psychiatry Cohort investigators, Bigdeli TB, Gabriel S, Zollner S, Smith AV, Abecasis G, McCarroll S, Pato MT, Pato CN, Boehnke M, Knowles J, Kang HM, Ophoff RA, Ernst J, Scott LJ. Whole genome sequence-based association analysis of African American individuals with bipolar disorder and schizophrenia. HGG Adv:100499, 2025 August, PMID: 40886051

Deane KD, Striebich CC, Feser ML, O'Dell JR, James JA, Sparks JA, Davis JM, Graf J, McMahon MA, Solow EB, Forbess L, Tiliakos A, Schiopu E, Danila MI, Horowitz DL, Kay J, Strickland CD, Guthridge JM, Arriens C, Grossman JM, Demoruelle MK, Bemis EA, Frazer-Abel A, Fleischer CL, Fox DA, Mikuls TR, Greenleaf M, York K, Walker S, Keyes-Elstein L, Byron M, Fedler J, Goldmuntz EA, Holers VM. A phase 2 trial of hydroxychloroquine in individuals at risk for rheumatoid arthritis. Arthritis Rheumatol, 2025 August, PMID: 40884017

Al-Naggar IM, Quinn CG, LaHue SC, Ocañas SR, Yousefzadeh M, Kozikowski C, McAbee-Sevick H, Campellone KG, Curran S, Justice JN, Orr ME, Thatcher C, Espinoza S, Newman JC, Pignolo RJ, Kuchel GA. Building an Interdisciplinary Workforce in Geroscience: Aligning Perspectives and Educational Goals. J Gerontol A Biol Sci Med Sci 80, 2025 August, PMID: 40850699, PMCID: PMC12375410

York LR, Ma H, Le Y, Griffin CT, Ding XQ. RIPK3 Contributes to Thyroid Hormone-Induced Photoreceptor Degeneration. Int J Mol Sci 26, 2025 August, PMID: 40943078, PMCID: PMC12428710

Ding Y, Chen J, Liu S, Hays JM, Gu X, Wren JD, Georgescu C, Reuter DN, Liu B, He F, Wang X, Wei Q, Wang J, Subramaniyan B, Wu Z, Kodali K, Reagan AM, Freeman WM, Miranti CK, Csiszar A, Ungvari Z, Mehla K, Walters MS, Elliott MH, Peng J, Kanie T, Papin JF, Hays FA, Zhang XA. Publisher Correction: Tetraspanin-enriched membrane domains regulate vascular leakage by altering membrane cholesterol accessibility to balance antagonistic GTPases. Nat Cardiovasc Res, 2025 August, PMID: 40841835

Merrill JT, Saxena A, Aringer M, Tanaka Y, Zeng X, Cheng L, Doan TT, D'Cruz D, Masri KR, D'Silva KM. Efficacy and safety of upadacitinib as monotherapy or combined with elsubrutinib for the treatment of systemic lupus erythematosus: results through 104 weeks in a long-term extension study. RMD Open 11, 2025 August, PMID: 40829888, PMCID: PMC12366599

Ali SR, Nguyen NUN, Elhelaly W, Hsu CC, Li S, Menendez-Montes I, Wang Z, Cui M, Elnwasany A, Xiao F, Sun J, Thet S, Lam NT, Cardoso A, Pereira AH, Wang J, Olson EN, Kinter MT, Szweda LI, Shelton J, Kimura W, Sadek HA. Paracrine IGFBP3 spatially coordinates IGF signaling to induce myocardial regeneration in mice. J Mol Cell Cardiol, 2025 August, PMID: 40829695

Hughes DC, Hettinger ZR, Deane CS. Androgen-Mediated Regulation of Skeletal Muscle Mass: A Ticking Clock. Function (Oxf), 2025 August, PMID: 40815271

Houmam S, Siodlak D, Pham KD, Salinas-Salinas C, Ocañas SR, Freeman WM, Rice HC. Protocol to isolate oligodendrocytes, microglia, endothelial cells, astrocytes, and neurons from a single mouse brain using magnetic-activated cell sorting. bioRxiv, 2025 August, PMID: 40832248, PMCID: PMC12363854

Wu Q, Mills EA, Wang Q, Mao G, Mao-Draayer Y. JCV-specific cell-based assays for PML risk assessment in lupus and multiple sclerosis patients with and without natalizumab. Front Neurol 16:1584083, 2025 August, PMID: 40832152, PMCID: PMC12360262

Castell SD, Fernandez CM, Tumas IN, Margara LM, Miserendino MC, Ceschin DG, Pezza RJ, Monti MR. The low-fidelity DNA Pol IV accelerates evolution of pathogenicity genes in Pseudomonas aeruginosa. Commun Biol 8:1148, 2025 August, PMID: 40753298, PMCID: PMC12318082

Blankenship HE, Higgs MH, Beckstead MJ. Enhanced synaptic excitation of VTA dopamine neurons in a mouse model of Alzheimer's disease. bioRxiv, 2025 July, PMID: 40766396, PMCID: PMC12324210

Rajala R, Griffin CT. Novel Function for Endothelial Protease-Activated Receptors in Modulating Insulin Receptor Activity With Implications for Diabetes. Arterioscler Thromb Vasc Biol, 2025 July, PMID: 40740132, PMCID: PMC12321246

Kennedy WM, Troyano-Rodriguez E, Higgs MH, Blankenship HE, Korukonda A, Weinshenker D, Rice HC, Beckstead MJ. Tau conveys intrinsic hyperactivity of VTA dopamine neurons but an inability to sustain burst firing. bioRxiv, 2025 July, PMID: 40766411, PMCID: PMC12324307

Ding Y, Chen J, Liu S, Hays JM, Gu X, Wren JD, Georgescu C, Reuter DN, Liu B, He F, Wang X, Wei Q, Wang J, Subramaniyan B, Wu Z, Kodali K, Reagan AM, Freeman WM, Miranti CK, Csiszar A, Ungvari Z, Mehla K, Walters MS, Elliott MH, Peng J, Kanie T, Papin JF, Hays FA, Zhang XA. Tetraspanin-enriched membrane domains regulate vascular leakage by altering membrane cholesterol accessibility to balance antagonistic GTPases. Nat Cardiovasc Res, 2025 July, PMID: 40731107

Porter HL, Ansere VA, Undi RB, Hoolehan W, Giles CB, Brown CA, Stanford D, Huycke MM, Freeman WM, Wren JD. Methylation array signals are predictive of chronological age without bisulfite conversion. Geroscience, 2025 July, PMID: 40721571

Baehr LM, de Sousa LGO, Goodman CA, Sharples AP, Waddell DS, Bodine SC, Hughes DC. Response of UBR-box E3 ubiquitin ligases and protein quality control pathways to perturbations in protein synthesis and skeletal muscle size. bioRxiv, 2025 July, PMID: 40777329, PMCID: PMC12330723

Davis MJ, Castorena-Gonzalez JA, Li M, Simon AM, Srinivasan RS. Hierarchical requirement for endothelial cell connexins Cx37, Cx47, Cx43 and Cx45 in lymphatic valve function. Function (Oxf), 2025 July, PMID: 40720769

Bouhatous YM, Bredrup C, Maurer A, Mirakovska L, Foster A, Kosaki K, Jost C, Demoulin JB, Luu M, Vabres P, Kurtz JE, Schaefer E, Guimier A, Cormier-Daire V, Lim D, Thompson S, Olson L, Kwon HR, Aguirre-Rodriguez C, Hernandez-Dorronsoro U, Martinez-Soroa I, Iznardo H, Mascaró JM Jr, Baselga E, Kalantari S, Mussa A, Gazzin A, Carli D, Svinvik I, Mutlu-Albayrak H, Bluefeather S, Zarate Y, Takenouchi T, Naicker T, Chateau A, Gokhul A, Dube-Pule A, Haniffa M, Ong Peitee W, Nordgren A, Carpentier M, Binquet C, Briffaut AS, Bal L, Pond D, Rustad CF, Bardou M, Faivre L. 'Knowing and Treating Kosaki/Penttinen syndrome' international collaborative consortium: recommendations for follow-up, natural history and a real-life observational study about safety and efficacy profile of tyrosine kinase inhibitors. J Med Genet, 2025 July, PMID: 40707250

Ahn C, Hevener AL, Goodyear LJ, Bodine SC, Esser KA, Seldin MM, Sparks LM. Exercise training remodels inter-organ endocrine networks. Mol Metab:102219, 2025 July, PMID: 40701293, PMCID: PMC12340562

Qin W, Lin SJ, Zhang Y, Huang K, Petree C, Boyd K, Varshney P, Varshney GK. Rationally Designed TadA-Derived Cytosine Editors Enable Context-Independent Zebrafish Genome Editing. Adv Sci (Weinh):e09800, 2025 July, PMID: 40685751

Hwang J, Gipson J, Xu C, VanWagoner T, Xu X, Agnew RJ, Freeman WM. Effects of Residual PAH Exposure from Firefighters' Skin and Turnout Gear on Biospecimen microRNA Expression. Environ Res:122348, 2025 July, PMID: 40659202

Mesquita PHC, Halle JL, Fuqua JD, Miller BF. Applying lessons from limb muscle disuse and ageing to better understand ventilator-induced diaphragm dysfunction. Exp Physiol, 2025 July, PMID: 40638619

Noble TD, Sansam CG, Wittig KA, Majchrzycka B, Sansam CL. Cell cycle-dependent TICRR/TRESLIN and MTBP chromatin binding mechanisms and patterns. Genome Biol 26:194, 2025 July, PMID: 40624716, PMCID: PMC12235874

Wu W, Alexander JS, Booth JL, Chlebicz M, Miller CA, Xu C, Kovats S, Metcalf JP. CYP1B1 knockout enhanced IFN-γ production is required but not sufficient for protection of cigarette smoke-exposed mice against lethal influenza virus infection. Front Immunol 16:1600025, 2025 July, PMID: 40688072, PMCID: PMC12271145

Varshney GK, Burgess SM. CRISPR-based functional genomics tools in vertebrate models. Exp Mol Med 57:1355-1372, 2025 July, PMID: 40745001, PMCID: PMC12322193

Silasi R, Keshari RS, Abe T, Byrum SD, Regmi G, Lupu C, Georgescu C, Simmons JH, Shamanaev A, Moellmer SA, Puy C, Shatzel JJ, Province D, Edmondson RD, Mackintosh SG, Avaritt NL, Bloomfield D, Gailani D, Tackett AJ, McCarty OJT, Lupu F. Protective Effects of FXI Inhibition by Abelacimab in a Baboon Model of Live Staphylococcus aureus Sepsis. J Thromb Haemost, 2025 June, PMID: 40582699

Shoctor NA, Brady MP, Lightman RR, Overton KN, Tandon S, Mathis SP, Rane MJ, Barati MT, Arriens CG, Powell DW, Caster DJ. Serum NF-κB-Regulated Biomarkers of Proliferative Lupus Nephritis. Glomerular Dis 5:328-343, 2025 June, PMID: 40786963, PMCID: PMC12334151

Converse A, Perry MJ, Dipali SS, Isola JVV, Kelly EB, Varberg JM, Zelinski MB, Stout MB, Pritchard MT, Duncan FE. Multinucleated giant cells are hallmarks of ovarian aging with unique immune and degradation-associated molecular signatures. PLoS Biol 23:e3003204, 2025 June, PMID: 40550000, PMCID: PMC12185119

Horisberger A, Griffith A, Keegan J, Arazi A, Pulford J, Murzin E, Howard K, Hancock B, Fava A, Sasaki T, Ghosh T, Inamo J, Beuschel R, Cao Y, Preisinger K, Gutierrez-Arcelus M, Eisenhaure TM, Guthridge J, Hoover PJ, Dall'Era M, Wofsy D, Kamen DL, Kalunian KC, Furie R, Belmont M, Izmirly P, Clancy R, Hildeman D, Woodle ES, Apruzzese W, McMahon MA, Grossman J, Barnas JL, Payan-Schober F, Ishimori M, Weisman M, Kretzler M, Berthier CC, Hodgin JB, Demeke DS, Putterman C, Brenner MB, Anolik JH, Raychaudhuri S, Hacohen N, James JA, Davidson A, Petri MA, Buyon JP, Diamond B, Zhang F, Lederer JA, Rao DA. Blood immunophenotyping identifies distinct kidney histopathology and outcomes in patients with lupus nephritis. J Clin Invest, 2025 June, PMID: 40536813, PMCID: PMC12352894

Liu Y, Gan T, Qi YY, Tan M, Xu LL, Li Y, Liu J, Qu S, Wang L, Chen G, Lv JC, Zhao ZZ, Bi W, Zhang P, Zhao MH, Tan Y, Nath SK, Zhang H, Zhou XJ. Genetic susceptibility to membranous lupus nephritis: a genome-wide association study. Ann Rheum Dis, 2025 June, PMID: 40537343

Sok SPM, Cheng J, Strucinska K, Popescu NI, Wu L, Ke Q, Kiosses WB, Stanford D, Freeman WM, Matsuzaki S, Lewis TL Jr, Zhao M. P-glycoprotein expression skews mitochondrial dye measurements in T cells. Front Immunol 16:1560104, 2025 June, PMID: 40607427, PMCID: PMC12213397

Ogunsanya ME, Beebe LA, Campbell JE, Holmes N, VanWagoner T, James J. Exploring barriers, needs, and facilitators for clinical and translational research in Oklahoma: A sequential mixed-methods study. J Clin Transl Sci 9:e155, 2025 June, PMID: 40895451, PMCID: PMC12392360

Sansam CG, Masser EA, Goins D, Sansam CL. Due-B Is dispensable for early development and genome duplication in vertebrates. bioRxiv, 2025 June, PMID: 40667299, PMCID: PMC12262730

Hossain MS, Sansam CG, Wittig KA, Noble TD, Boyd KA, Sansam CL. Dynamic regulation of origin firing factors links CDK activity to dormant origin activation. bioRxiv, 2025 June, PMID: 40661636, PMCID: PMC12259077

Szulta A, Wang L, Hasan A, Kinter M, Pranay A, Zhu J, Humphries KM, Loveland B, Griffin TM, Bieniasz M. The Identification of a Key Regulator of Mitochondrial Metabolism, the LRPPRC Protein, as a Novel Therapeutic Target in SDHA-Overexpressing Ovarian Tumors. Cancers (Basel) 17, 2025 June, PMID: 40563592, PMCID: PMC12190274

Ramos-Casals M, Baer AN, Brito-Zerón MDP, Hammitt KM, Bouillot C, Retamozo S, Mackey A, Yarowsky D, Turner B, Blanck J, Fisher BA, Akpek EK, Baldini C, Bootsma H, Bowman SJ, Dörner T, Laing L, Lieberman SM, Mariette X, Pflugfelder SC, Sankar V, Sisó-Almirall A, Tzioufas AG, Anaya JM, Armağan B, Bombardieri M, Carsons S, de Vita S, Fox RI, Gerli R, Giacomelli R, Gottenberg JE, Hernández-Molina G, Jonsson R, Kruize A, Kwok SK, Li X, McCoy SS, Ng WF, Olsson P, Rischmueller M, Saraux A, Scofield RH, Valim V, Vitali C, Vivino F, Wahren-Herlenius M, Moutsopoulos HM, International Task Force on Nomenclature of Sjögren Disease. 2023 International Rome consensus for the nomenclature of Sjögren disease. Nat Rev Rheumatol, 2025 June, PMID: 40494962

Das S, Varshney RR, Farriester JW, Kyere-Davies G, Martinez AE, Hill KB, Kinter M, Mullen GP, Nagareddy PR, Rudolph MC. Activating nuclear receptor subfamily 2 group F member 2 in adipocyte stem cells rescues beige adipocyte metabolism impaired by excess early-life omega-6 fatty acids. Clin Nutr 51:63-80, 2025 June, PMID: 40527120, PMCID: PMC12257918

Eeda V, Hedrick AF, Pranay A, Humphries KM, Heidenreich E, Awasthi V. Cardiotropic ligand-guided liposomes for myocardial delivery of atorvastatin in a mouse model of myocardial infarction. Int J Pharm 681:125841, 2025 June, PMID: 40499599

Williams AP, Turner S, Chlebicz M, Carter H, Miller RAJ, Allushi B, Roe MM, Mejia LL, Labombarde J, Alberola-Ila J, Kovats S. Cutting edge: Extrinsic and intrinsic sex effects differentially regulate pulmonary ILC2 numbers, phenotype, and function. J Immunol, 2025 June, PMID: 40489769, PMCID: PMC12394977

Biswas I, Kudo M, Rezaie AR. Endothelial Protein C Receptor and Thrombomodulin Facilitate Protease-Activated Receptor 1 Cleavage at Arginine-46 by Thrombin and Activated Protein C. J Biol Chem:110339, 2025 June, PMID: 40480637, PMCID: PMC12269503

Brawner CM, Sturdy C, Arbeeva L, Golightly YM, Nelson AE, Jeffries MA. Borderline acceleration in blood epigenetic age of unclear biological importance in knee OA progression: Specimens and data from the Osteoarthritis Initiative and Johnston County Osteoarthritis Project. Osteoarthritis Cartilage, 2025 June, PMID: 40480605, PMCID: PMC12354273

Kurup K, Chan M, Moore E, Ranjo-Bishop M, Pham K, Stanford DR, Freeman WM, Unnikrishnan A. Late-life short-term dietary restriction improves intestinal stem cell function and alters intestinal stem cell DNA methylation in mice. J Nutr, 2025 May, PMID: 40456408, PMCID: PMC12346696

Wiley MM, Radziszewski M, Khatri B, Joachims ML, Tessneer KL, Stolarczyk AM, Yao S, Li J, Pritchett-Frazee C, Johnston AA, Rasmussen A, Anaya JM, Aqrawi LA, Bae SC, Baecklund E, Björk A, Brun JG, Bucher SM, Dand N, Eloranta ML, Engelke F, Forsblad-d'Elia H, Fugmann C, Glenn SB, Gong C, Gottenberg JE, Hammenfors D, Imgenberg-Kreuz J, Jensen JL, Johnsen SJA, Jonsson MV, Kelly JA, Khanam S, Kim K, Kvarnström M, Mandl T, Martín J, Morris DL, Nocturne G, Norheim KB, Olsson P, Palm Ø, Pers JO, Rhodus NL, Sjöwall C, Skarstein K, Taylor KE, Tombleson P, Thorlacius GE, Venuturupalli SR, Vital EM, Wallace DJ, Radfar L, Brennan MT, James JA, Scofield RH, Gaffney PM, Criswell LA, Jonsson R, Appel S, Eriksson P, Bowman SJ, Omdal R, Rönnblom L, Warner BM, Rischmueller M, Witte T, Farris AD, Mariette X, Shiboski CH, Sjögren’s International Collaborative Clinical Alliance (SICCA), Wahren-Herlenius M, Alarcón-Riquelme ME, PRECISESADS Clinical Consortium, Ng WF, UK Primary Sjögren’s Syndrome Registry, Sivils KL, Guthridge JM, Adrianto I, Vyse TJ, Tsao BP, Nordmark G, Lessard CJ. Variants in the DDX6-CXCR5 autoimmune disease risk locus influence the regulatory network in immune cells and salivary gland. Ann Rheum Dis, 2025 May, PMID: 40447495, PMCID: PMC12236377

Jiang K, Fu Y, Kelly JA, Gaffney PM, Holmes LC, Jarvis JN. Defining three dimensional chromatin structures of pediatric and adolescent B cells using primary B cell and EBV-immortalized B cell reference genomes. BMC Med Genomics 18:97, 2025 May, PMID: 40437445, PMCID: PMC12117681

Graham ZA, Bubak MP, Raymond-Pope CJ, Cutter GR, McAdam JS, Tuggle SC, Siedlik JA, de Sousa LGO, Chappe EJ, Meece K, Kaur A, Ruiz BSR, Bamman SC, Vanselow KM, Perry TW, Acosta-Arreguin JS, Bohmke NJ, Addison GJ, Bowers JM, Wright RL, Fuentes LD, Smith JE, Esser KA, Miller BF, Bodine SC, Bamman MM. Multidimensional Modeling to Maximize Adaptations to eXercise: The M(3)AX Trial Rationale and Study Design. medRxiv, 2025 May, PMID: 40492097, PMCID: PMC12148272

Harold KM, Matsuzaki S, Pranay A, Zhu J, Faakye A, Humphries KM. PFKFB2 is Pivotal for Metabolic Flexibility and Differential Glucose Utilization. bioRxiv, 2025 May, PMID: 40502119, PMCID: PMC12154713

Eyster C, Matsuzaki S, Pranay A, Giorgione JR, Faakye A, Ahmed M, Humphries KM. Mechanistic studies of PFKFB2 reveal a novel inhibitor of its kinase activity. PLoS One 20:e0317167, 2025 May, PMID: 40402947, PMCID: PMC12097583

Bodine SC, Goodman CA. Mechanically sensitive MAPK signalling mediates resistance exercise-induced muscle growth. Nat Metab, 2025 May, PMID: 40374924

Pasionek I, Machowska A, Ridenour JB, Donczew M, Donczew R. The extra-terminal domain drives the role of BET proteins in transcription. bioRxiv, 2025 May, PMID: 40463266, PMCID: PMC12132590

Nguyen NGT, Sapkota H, Shibata Y, Fesiuk A, Antalek M, Sail V, Ansel DJ, Amici DR, Peelor FF, Van Remmen H, Miller BF, Mendillo ML, Morimoto RI, Li J. HSF1 remodels mitochondrial biogenesis and function in cancer cells via TIMM17A. bioRxiv, 2025 May, PMID: 40463013, PMCID: PMC12132197

Drumond-Bock AL, Blankenship HE, Pham KD, Carter KA, Freeman WM, Beckstead MJ. Parallel gene expression changes in ventral midbrain dopamine and GABA neurons during normal aging. eNeuro, 2025 May, PMID: 40360281, PMCID: PMC12121937

Tang Y, Song X, Zhang Z, Yao Y, Pan T, Qi J, Xia L, Wu D, Han Y. Hypermethylation of DNA impairs megakaryogenesis in delayed platelet recovery after allogeneic hematopoietic stem cell transplantation. Sci Adv 11:eads3630, 2025 May, PMID: 40333970, PMCID: PMC12057652

Allushi B, Chlebicz M, Kumar G, Massey K, Labombarde JG, Turner S, Miller RAJ, Williams AP, Quinn A, Kovats S, Axtell RC. Interferon-β treatment reverses the detrimental effect of B-cell depletion therapy on respiratory virus infection. J Immunol, 2025 May, PMID: 40334083, PMCID: PMC12311375

Dominguez D, Vaclaw S, McClard CK, Jeffries MA, Noori J. Successful Use of Upadacitinib, a Selective JAK Inhibitor, in the Treatment of Two Cases of Recalcitrant Chronic Uveitis. J Ophthalmic Vis Res 20, 2025 May, PMID: 40689111, PMCID: PMC12258069

Ahn C, Hevener AL, Goodyear LJ, Bodine SC, Esser KA, Seldin MM, Sparks LM. Exercise training remodels inter-organ endocrine networks. bioRxiv, 2025 May, PMID: 40654889, PMCID: PMC12248110

Tsaliki M, Cavett J, Kurien BT, Bruxvoort C, Lewis VM, Ice JA, Dave D, Khosravani S, Grundahl K, Lessard CJ, Rasmussen A, Sivils KL, Farris AD, Koelsch KA, Scofield RH. A cross-sectional observational study of patients with sicca with salivary autoantibodies defines a potential new phenotype of Sjögren's disease. Ann Rheum Dis, 2025 May, PMID: 40320334

Han F, Simeroth S, Zhu J, Gryniuk I, Pranay A, Chen W, Wang Y, Cai Y, Shen Z, Wang G, Griffin CT, Xia L, Yu P. Lymphatic endothelial mTORC1 instructs metabolic and developmental signaling during lymphangiogenesis. Dev Cell, 2025 May, PMID: 40339577, PMCID: PMC12353337

Wagner CA, James JA. Risks and benefits of immunosuppressant withdrawal in systemic lupus erythematosus. Nat Rev Rheumatol, 2025 May, PMID: 40316794

Faakye A, Harold KM, Matsuzaki S, Pranay A, Mendez Garcia MF, Loveland BL, Rigsby SN, Peelor FF 3rd, Eyster C, Miller BF, Griffin TM, Kinter M, Chiao YA, Humphries KM. The effect of enhanced glycolysis on cardiac aging. Geroscience, 2025 May, PMID: 40310487

O'Reilly CL, Davidyan A, Cizio K, Doidge SM, Bubak MP, Borowik AK, Lewis TL Jr, Miller BF. Combining In Vivo 2-Photon Imaging with Photoactivatable Fluorescent Labeling Shows Low Rates of Mitochondrial Dynamics in Skeletal Muscle. Med Sci Sports Exerc, 2025 May, PMID: 40310022, PMCID: PMC12323594

Woods JP, Rackley A, Kwon HR, Olson LE. PDGFRα signaling regulates cartilage and fibrous tissue differentiation during synovial joint development. Nat Commun 16:4041, 2025 April, PMID: 40301343, PMCID: PMC12041487

Kurien BT, Ice JA, Wood RA, Pharaoh G, Cavett J, Lewis V, Bhaskaran S, Rasmussen A, Lessard CJ, Farris AD, Sivilis K, Koelsch KA, Van Remmen H, Scofield RH. Mitochondrial dysfunction and fatigue in Sjögren's disease. RMD Open 11, 2025 April, PMID: 40274303, PMCID: PMC12020762

Wood TWP, Henriques WS, Cullen HB, Romero M, Blengini CS, Sarathy S, Sorkin J, Bekele H, Jin C, Kim S, Wang X, Laureau R, Chemiakine A, Khondker RC, Isola JVV, Stout MB, Gennarino VA, Mogessie B, Jain D, Schindler K, Suh Y, Wiedenheft B, Berchowitz LE. The retrotransposon-derived capsid genes PNMA1 and PNMA4 maintain reproductive capacity. Nat Aging, 2025 April, PMID: 40263616, PMCID: PMC12180178

Chandrakesan P, Yao J, Qu D, May R, Weygant N, Ge Y, Ali N, Sureban SM, Gude M, Vega K, Bannerman-Menson E, Xia L, Bronze M, An G, Houchen CW. Retraction Note: Dclk1, a tumor stem cell marker, regulates pro-survival signaling and self-renewal of intestinal tumor cells. Mol Cancer 24:120, 2025 April, PMID: 40253332, PMCID: PMC12008944

Reidy M, Khan M, Mills EA, Wu Q, Garton J, Draayer DE, Zahoor I, Giri S, Axtell RC, Mao-Draayer Y. New Frontiers in Multiple Sclerosis Treatment: From Targeting Costimulatory Molecules to Bispecific Antibodies. Int J Mol Sci 26, 2025 April, PMID: 40332536, PMCID: PMC12028294

Fox RJ, Cohan S, Mao-Draayer Y, Weinstock-Guttman B, Cruz LA, Arnould S, Cox GM, Bar-Or A. Safety and tolerability of conversion to siponimod from other disease-modifying therapies in patients with advancing forms of relapsing MS: Results from the EXCHANGE study. Mult Scler:13524585251330085, 2025 April, PMID: 40248858, PMCID: PMC12280243

Mahendrawada L, Warfield L, Donczew R, Hahn S. Low overlap of transcription factor DNA binding and regulatory targets. Nature, 2025 April, PMID: 40240607

Basu A, Hooyman A, Groven S, Devillez P, Scofield RH, Ebersole JL, Champion A, Izuora K. Strawberries improve insulin resistance and related cardiometabolic markers in adults with prediabetes: a randomized controlled crossover trial. J Nutr, 2025 April, PMID: 40250566

Efthymiou S, Leo CP, Deng C, Lin SJ, Maroofian R, Lin R, Karagoz I, Zhang K, Kaiyrzhanov R, Scardamaglia A, Owrang D, Turchetti V, Jahnke F, Huang K, Petree C, Derrick AV, Rees MI, Alvi JR, Sultan T, Li C, Jacquemont ML, Tran-Mau-Them F, Valenzuela-Palafoll M, Sidlow R, Yoon G, Morrow MM, Carere DA, O'Connor M, Fleischer J, Gerkes EH, Phornphutkul C, Isidor B, Rivier-Ringenbach C, Philippe C, Kurul SH, Soydemir D, Kara B, Sunnetci-Akkoyunlu D, Bothe V, Platzer K, Wieczorek D, Koch-Hogrebe M, Rahner N, Thuresson AC, Matsson H, Frykholm C, Bozdoğan ST, Bisgin A, Chatron N, Lesca G, Cabet S, Tümer Z, Hjortshøj TD, Rønde G, Marquardt T, Reunert J, Afzal E, Zamani M, Azizimalamiri R, Galehdari H, Nourbakhsh P, Chamanrou N, Chung SK, Suri M, Benke PJ, Zaki MS, Gleeson JG, Calame DG, Pehlivan D, Yilmaz HI, Gezdirici A, Rad A, Abumansour IS, Oprea G, Bereketoğlu MB, Banneau G, Julia S, Zeighami J, Ashoori S, Shariati G, Sedaghat A, Sabri A, Hamid M, Parvas S, Tajudin TA, Abdullah U, Baig SM, Chung WK, Glazunova OO, Sabine S, Cheema HA, Zifarelli G, Bauer P, Sidpra J, Mankad K, Vona B, Fry AE, Varshney GK, Houlden H, Fu D. Biallelic pathogenic variants in TRMT1 disrupt tRNA modification and induce a neurodevelopmental disorder. Am J Hum Genet, 2025 April, PMID: 40245862, PMCID: PMC12120178

Sharpe AL, Liter LR, Donohue D, Carter KA, Vangeneugden P, Weaver SM, Stout MB, Beckstead MJ. Aged mice exhibit faster acquisition of intravenous opioid self-administration with variable effects on intake. Neuropharmacology:110464, 2025 April, PMID: 40228626, PMCID: PMC12065658

Hatipoglu I, Ainsua-Enrich E, Kadel S, Turner S, Singh S, Kovats S. IRF4-regulated transcriptional and functional heterogeneity of lung-resident CD11b cDC2 subsets during influenza virus infection. J Immunol, 2025 April, PMID: 40209091, PMCID: PMC12123216

Kobak KA, Zarzycka W, King CJ, Borowik AK, Peelor FF 3rd, Baehr LM, Leutert M, Rodriguez-Mias RA, Villén J, Bodine SC, Kinter MT, Miller BF, Chiao YA. Proteostatic Imbalance Drives the Pathogenesis and Age-Related Exacerbation of Heart Failure With Preserved Ejection Fraction. JACC Basic Transl Sci 10:475-497, 2025 April, PMID: 40306856, PMCID: PMC12134603

Tsou PS, Ali RA, Lu C, Sule G, Carmona-Rivera C, Lucotti S, Ikari Y, Wu Q, Campbell P, Gurrea-Rubio M, Maeda K, Fox SE, Brodie WD, Mattichak MN, Foster C, Tambralli A, Yalavarthi S, Amin MA, Kmetova K, Mazetto Fonseca B, Chong E, Zuo Y, Maile M, Imberti L, Caruso A, Caccuri F, Quaresima V, Sottini A, Kuhns DB, Fink DL, Castagnoli R, Delmonte O, Kenney H, Zhang Y, Magliocco M, Su HC, Notarangelo LD, Zemans RL, Mao-Draayer Y, Matei I, Salvatore M, Lyden DC, Kanthi Y, Kaplan MJ, Knight JS, Fox DA. Soluble CD13 is a potential mediator of neutrophil-induced thrombogenic inflammation in SARS-CoV-2 infection. JCI Insight, 2025 April, PMID: 40168094, PMCID: PMC12128962

Pachman LM, Khojah A, Morgan G, Marin W, James J, Kadri S, Yap KL. Monozygotic twins discordant for juvenile dermatomyositis: clinical, serological and gene expression studies. Pediatr Rheumatol Online J 23:32, 2025 March, PMID: 40140985, PMCID: PMC11938629

Rajala R, Griffin CT. A novel function for endothelial protease-activated receptors in modulating insulin receptor activity with implications for diabetes. bioRxiv, 2025 March, PMID: 40196641, PMCID: PMC11974755

Myers JM, Sandel C, Alvarez K, Garman L, Wiley G, Montgomery C, Gaffney P, Stavrakis S, Fairweather D, Bruno KA, Zhao YD, Cooper LT, Cunningham MW. Cardiac autoantibodies promote a fibrotic transcriptome and reduced ventricular recovery in human myocarditis. Front Immunol 16:1500909, 2025 March, PMID: 40181955, PMCID: PMC11965655

Inamo J, Keegan J, Griffith A, Ghosh T, Horisberger A, Howard K, Pulford JF, Murzin E, Hancock B, Dominguez ST, Gurra MG, Gurajala S, Jonsson AH, Seifert JA, Feser ML, Norris JM, Cao Y, Apruzzese W, Bridges SL, Bykerk VP, Goodman S, Donlin LT, Firestein GS, Bathon JM, Hughes LB, Filer A, Pitzalis C, Anolik JH, Moreland L, Hacohen N, Guthridge JM, James JA, Cuda CM, Perlman H, Brenner MB, Raychaudhuri S, Sparks JA, Accelerating Medicines Partnership RA/SLE Network, Holers VM, Deane KD, Lederer J, Rao DA, Zhang F. Deep immunophenotyping reveals circulating activated lymphocytes in individuals at risk for rheumatoid arthritis. J Clin Invest 135, 2025 March, PMID: 40091833, PMCID: PMC11910230

Abboud H, Steingo B, Vargas D, Patel J, Nealon N, Willis MA, Mao-Draayer Y, Khaitov D, Tsai M, Kim A, Pandey K, Levy M, Molazadeh N, Romero RS, Ferayorni L, Gholizadeh S. Satralizumab treatment in patients with AQP4-IgG-seropositive neuromyelitis optica spectrum disorder after rituximab treatment: A case series. J Neuroimmunol 403:578585, 2025 March, PMID: 40132364

Murach KA, Englund DA, Chambers TL, Dungan CM, Porter HL, Wren JD, Freeman WM, Dupont-Versteegden EE, Wen Y. A satellite cell-dependent epigenetic fingerprint in skeletal muscle identity genes after lifelong physical activity. FASEB J 39:e70435, 2025 March, PMID: 40047419, PMCID: PMC11884312

Burge KY, Georgescu C, Zhong H, Wilson AP, Gunasekaran A, Yu Z, Franca A, Eckert JV, Wren JD, Chaaban H. Spatial transcriptomics delineates potential differences in intestinal phenotypes of cardiac and classical necrotizing enterocolitis. iScience 28:112166, 2025 March, PMID: 40201118, PMCID: PMC11978348

Lin SJ, Huang K, Petree C, Qin W, Varshney P, Varshney GK. Optimizing gRNA selection for high-penetrance F0 CRISPR screening for interrogating disease gene function. Nucleic Acids Res 53, 2025 February, PMID: 40103232, PMCID: PMC11915512

Cerqueira JJ, Berthele A, Cree BAC, Filippi M, Pardo G, Pearson OR, Traboulsee A, Ziemssen T, Vollmer T, Bernasconi C, Mandel CR, Kulyk I, Chognot C, Raposo C, Schneble HM, Thanei GA, Incera E, Havrdová EK. Long-Term Treatment With Ocrelizumab in Patients With Early-Stage Relapsing MS: Nine-Year Data From the OPERA Studies Open-Label Extension. Neurology 104:e210142, 2025 February, PMID: 39883906, PMCID: PMC11781784

Wu C, Chen D, Stout MB, Wu M, Wang S. Hallmarks of ovarian aging. Trends Endocrinol Metab, 2025 February, PMID: 40000274

Zaslavsky ME, Craig E, Michuda JK, Sehgal N, Ram-Mohan N, Lee JY, Nguyen KD, Hoh RA, Pham TD, Röltgen K, Lam B, Parsons ES, Macwana SR, DeJager W, Drapeau EM, Roskin KM, Cunningham-Rundles C, Moody MA, Haynes BF, Goldman JD, Heath JR, Chinthrajah RS, Nadeau KC, Pinsky BA, Blish CA, Hensley SE, Jensen K, Meyer E, Balboni I, Utz PJ, Merrill JT, Guthridge JM, James JA, Yang S, Tibshirani R, Kundaje A, Boyd SD. Disease diagnostics using machine learning of B cell and T cell receptor sequences. Science 387:eadp2407, 2025 February, PMID: 39977494, PMCID: PMC12061481

Gui H, Lessard CJ, Liu J, Li M, Adrianto I. Editorial: Integrative genetics and multi-omics of complex human disorders. Front Genet 16:1574431, 2025 February, PMID: 40061127, PMCID: PMC11885495

Scofield RH, Wren JD, Lewis VM. The toll like receptor 7 pathway and the sex bias of systemic lupus erythematosus. Front Immunol 16:1479814, 2025 February, PMID: 40051623, PMCID: PMC11882868

Anderson M, Scofield RH. The "Fixed Period," the Wildfire News, and an Unpublished Manuscript: Osler's Farewell Speech Revisited in Geographical Breadth and Emotional Depth. Am J Med Sci, 2025 February, PMID: 39947325

Rajala R, Griffin CT. Kinome profiling: A veritable Rosetta stone for protease-activated receptor 1 biased signaling. Vascul Pharmacol:107469, 2025 February, PMID: 39904417, PMCID: PMC11890924

Drumond-Bock AL, Beckstead MJ. Ketones on the Brain: Can Diet Help Turn the Tables on Parkinson's?-Commentary on Mahajan et al. (2024). Eur J Neurosci 61:e70025, 2025 February, PMID: 39937087

Yuan X, Qin X, Takemoto K, Zhao J, Sanderson M, Xu X, Zhang Y, Helke KL, Jacobs Wolf B, Guthridge JM, James JA, Zhou X, Assassi S, Feghali-Bostwick C, Wang D, Sun L, Tsao BP. Human hypofunctional NCF1 variants promote pulmonary fibrosis in the bleomycin-induced mouse model and patients with systemic sclerosis via expansion of SPP1( ) monocytes-derived macrophages. Ann Rheum Dis 84:294-306, 2025 February, PMID: 39919902, PMCID: PMC11907366

Sklivas AB, Hettinger ZR, Rose S, Mantuano A, Confides AL, Rigsby S, Peelor FF 3rd, Miller BF, Butterfield TA, Dupont-Versteegden EE. Responses of skeletal muscle to mechanical stimuli in female rats following and during muscle disuse atrophy. J Appl Physiol (1985), 2025 January, PMID: 39884317, PMCID: PMC12184423

Rajala R, Griffin CT. Endothelial protease-activated receptor 4: impotent or important? Front Cardiovasc Med 12:1541879, 2025 January, PMID: 39935714, PMCID: PMC11810968

Merrill JT, Gaudreau MC, D'Silva KM. Reply. Arthritis Rheumatol, 2025 January, PMID: 39953664

Radhakrishna U, Kuracha MR, Hamzavi I, Saiyed N, Prajapati J, Rawal RM, Uppala LV, Damiani G, Ratnamala U, Nath SK. Impaired Molecular Mechanisms Contributing to Chronic Pain in Patients with Hidradenitis Suppurativa: Exploring Potential Biomarkers and Therapeutic Targets. Int J Mol Sci 26, 2025 January, PMID: 39940809, PMCID: PMC11817842

Zahoor I, Nematullah M, Ahmed ME, Fatma M, Sajad M, Ayasolla K, Cerghet M, Palaniyandi S, Ceci V, Carrera G, Buttari F, Centonze D, Mao-Draayer Y, Rattan R, Chiurchiù V, Giri S. Maresin-1 promotes neuroprotection and modulates metabolic and inflammatory responses in disease-associated cell types in preclinical models of Multiple Sclerosis. J Biol Chem:108226, 2025 January, PMID: 39864620, PMCID: PMC11903811

Tang W, Wang K, Feng Y, Tsui KH, Singh KK, Stout MB, Wang S, Wu M. Exploration of the mechanism and therapy of ovarian aging by targeting cellular senescence. Life Med 4:lnaf004, 2025 January, PMID: 40110109, PMCID: PMC11916902

Griffin TM, Komaravolu RK, Lopes EBP, Mehta-D'souza P, Conner T, Kovats T, Kovats S, Allen M, Harris P, Humphrey MB, Welhaven HD, Brahmachary P, June RK. Exercise induces dynamic changes in intra-articular metabolism and inflammation associated with remodeling of the infrapatellar fat pad in mice. Sci Rep 15:2428, 2025 January, PMID: 39827311, PMCID: PMC11743197

Gurrea-Rubio M, Lin F, Wicha MS, Mao-Draayer Y, Fox DA. Ligands of CD6: roles in the pathogenesis and treatment of cancer. Front Immunol 15:1528478, 2025 January, PMID: 39840036, PMCID: PMC11747410

Laumonnerie C, Shamambo M, Stabley DR, Lewis TL Jr, Trivedi N, Howell D, Solecki DJ. Siah2 antagonism of Pard3/JamC modulates Ntn1-Dcc signaling to regulate cerebellar granule neuron germinal zone exit. Nat Commun 16:355, 2025 January, PMID: 39774925, PMCID: PMC11706986

Strucinska K, Kneis P, Pennington T, Cizio K, Szybowska P, Morgan A, Weertman J, Lewis TL Jr. Fis1 is required for the development of the dendritic mitochondrial network in pyramidal cortical neurons. bioRxiv, 2025 January, PMID: 39829888, PMCID: PMC11741399

Plafker KS, Georgescu C, Pezant N, Pranay A, Plafker SM. Sulforaphane acutely activates multiple starvation response pathways. Front Nutr 11:1485466, 2025 January, PMID: 39867556, PMCID: PMC11758633

De Kumar B, Krishnan J. Guidelines to Analyze ChIP-Seq Data: Journey Through QC and Analysis Considerations. Methods Mol Biol 2889:193-206, 2025 January, PMID: 39745614

Rallabandi HR, Singh MK, Looger LL, Nath SK. Defining Mechanistic Links Between the Non-Coding Variant rs17673553 in CLEC16A and Lupus Susceptibility. Int J Mol Sci 26, 2025 January, PMID: 39796169, PMCID: PMC11720054

Chhipa RR, Kurien BT, Scofield RH, Wolf RF, Huang H, Sundaram P. Amytrapper Catheter: A Prototype Extracorporeal Device That Traps Blood Amyloid-β in a Rat Model of Alzheimer's Disease. Am J Alzheimers Dis Other Demen 40:15333175251361265, 2025 January, PMID: 40676911, PMCID: PMC12276522

Dyson G, Barrett M, Schlupp L, Prinz E, Hannebut N, Szymczak A, Brawner CM, Jeffries MA. Ketogenic Diet-Associated Worsening of Osteoarthritis Histologic Secerity, Increased Pain Sensitivity and Gut Microbiome Dysbiosis in Mice. ACR Open Rheumatol 7:e11794, 2025 January, PMID: 39853943, PMCID: PMC11760994