Blood and lymphatic vessels are critical to human health. Blood vessels supply every tissue in the body with blood and oxygen, while lymphatic vessels pick up rogue fluids that leak into tissues from the bloodstream and return them to the circulatory system for disposal.
When problems arise in these systems, the consequences can be dire and may cause diabetic retinopathy, a blindness-causing eye disease frequently seen in diabetic patients, or lymphedema, a painful swelling of the limbs. They can also contribute to cancer metastasis and atherosclerosis, among other serious conditions.
My lab is specifically interested in studying the endothelial cells that make up the lining of the blood and lymphatic vessels. We study cellular glucose metabolism, which governs how these cells use sugar and convert it into energy. This process can go wrong, with either too much or too little sugar converted, and in some cases, it can contribute to disease.
Using novel methods for studying these mechanisms, we hope to gain a better understanding of how to manipulate these cellular processes and develop new means of controlling the pathways that can lead to disease.
B.S., Shandong University, China, 2005
Ph.D., Institute of Neuroscience, Chinese Academy of Sciences, China, 2010
Postdoctoral training, Yale University School of Medicine, 2012-2018
Honors and Awards
2018 Travel Award, International Vascular Biology Meeting, Helsinki
2015 American Heart Association Postdoctoral Fellowship
2010 ZhuLiYueHua Award for Outstanding Ph.D. Graduates, Chinese Academy of Sciences
Joined OMRF’s scientific staff in 2018
Yu P, Wilhelm K, Dubrac A, Tung JK, Alves TC, Fang JS, Xie Y, Zhu J, Chen Z, Smet FD, Zhang J, Jin SW, Sun L, Sun H, Kibbey RG, Hirschi KK, Hay N, Carmeliet P, Chittenden TW, Eichmann A, Potente M, & Simons M (2017). FGF-dependent metabolic control of vascular development. Nature 545(7653):224-228. PMID: 28467822
Yu P, Wu G, Lee HW, & Simons M (2018). Endothelial Metabolic Control of Lymphangiogenesis. BioEssays 40(6):e1700245. PMID: 29750374
Yu P, Tung JK, & Simons M (2014). Lymphatic fate specification: an ERK-controlled transcriptional program. Microvascular Research 96:10-15. PMID: 25132472
Tirziu D, Jaba IM, Yu P, Larrivée B, Coon BG, Cristofaro B, Zhuang ZW, Lanahan AA, Schwartz MA, Eichmann A, & Simons M (2012). Endothelial nuclear factor-κB-dependent regulation of arteriogenesis and branching. Circulation 126(22):2589-2600. PMID: 23091063
Yu P* & Du JL* (2011). Transient receptor potential canonical channels in angiogenesis and axon guidance. Cellular and Molecular Life Sciences 68(23):3815-3821. PMID: 21755360. (* Co-corresponding authors)
Yu P, Gu SY, Bu JW, & Du JL (2010). TRPC1 is essential for in vivo angiogenesis in zebrafish. Circulation Research 106(7):1221-1232. PMID: 20185799. (Highlighted in Faculty of 1000)
Huang C, Gu S, Yu P, Yu F, Feng C, Gao N, & Du J (2010). Deficiency of smarcal1 causes cell cycle arrest and developmental abnormalities in zebrafish. Developmental Biology 339(1):89-100. PMID: 20036229
Chen YM, Wang QJ, Hu HS, Yu P, Zhu J, Drewes G, Piwnica-Worms H, & Luo ZG (2006). Microtubule affinity-regulating kinase 2 functions downstream of the PAR-3/PAR-6/atypical PKC complex in regulating hippocampal neuronal polarity. Proc. Natl. Acad. Sci. USA 103(22):8534-8539. PMID: 16717194
Cardiovascular Biology Research Program
Oklahoma Medical Research Foundation
825 N.E. 13th Street
Oklahoma City, OK 73104