Cardiovascular Biology Research Program

The Cardiovascular Biology Research Program investigates fundamental mechanisms involved in blood and lymphatic vessel function, atherogenesis, blood coagulation, inflammation, and sepsis.

This program utilizes a multidisciplinary approach to address these questions at a molecular level. This approach encompasses structural biology, structure-function analysis of enzymes and receptors, regulation of the relevant genes, in vivo studies using transgenic and gene deletion approaches, cell biology, protein chemistry, physiological studies, and biophysical methods for analyzing protein-protein, membrane-protein, and cell-cell interactions.

The multidisciplinary approach provides insights into processes with relevance to many human diseases, including heart attack, stroke, septic shock, cancer, and inflammatory bowel disease. Several findings by program members have generated patents and licenses that may lead to new diagnostics and therapeutics.

2025

Keshari RS, Silasi R, Byrum SD, Popescu NI, Regmi G, Abe T, Lupu C, Georgescu C, Taylor VE, Province D, Edmondson RD, Mackintosh SG, Avaritt NL, Kovats S, Farris AD, Simmons JH, McCarty OJT, Tackett AJ, Lupu F. Anthrax Toxins Exacerbate Sepsis-Induced Coagulopathy and Endothelial Dysfunction in a Baboon Model of Anthrax. J Thromb Haemost, 2025 November, PMID: 41192570

Johnson CF, Schafer CM, Burge KY, Coon BG, Chaaban H, Griffin CT. RIPK3 Protects Against Endothelial Activation and Vascular Permeability in a Mouse Model of Ischemia-Reperfusion Injury. Arterioscler Thromb Vasc Biol, 2025 October, PMID: 41164879

Rathnakar BH, Rackley A, Kwon HR, Kim JH, Berry WL, Olson LE. Mouse scalp development requires Rac1 and SRF for the maintenance of mechanoresponsive mesenchyme. Development, 2025 October, PMID: 41126757

Kondo Y, Jiang Y, Geng X, Song J, Simeroth S, McDaniel JM, Yu P, Srinivasan RS, Xia L. Site-1 protease-mediated cholesterol metabolism is essential for lymphatic development in mice. JCI Insight 10, 2025 October, PMID: 41122969, PMCID: PMC12581667

Kim JD, Chaudhary S, Chen W, Astin J, Crosier PS, Yu P, Cooke JP, Pownall HJ, Bellen HJ, Le NT, Kiss DL, Wang G, Rockson SG, Chen H, Fang L. APOA1 binding protein promotes lymphatic cell fate and lymphangiogenesis by relieving caveolae-mediated inhibition of VEGFR3 signaling. Nat Commun 16:9286, 2025 October, PMID: 41120256, PMCID: PMC12540785

Ma E, Schafer CM, Xie J, Rudenko Y, Knapp JTH, Randi AM, Birdsey GM, Griffin CT. Targeting endothelial ERG to mitigate vascular regression in retinopathies. Proc Natl Acad Sci U S A 122:e2507194122, 2025 September, PMID: 40986356, PMCID: PMC12501155

Negri S, Nyul-Toth A, Milan M, Troyano-Rodriguez E, Tavakol S, Ihuoma J, Reyff Z, Rudraboina R, Gulej R, Jang R, Csiszar A, Ungvari Z, Cleuren A, Miller DR, Yabluchanskiy A, Tanter M, Tarantini S. A Minimally Invasive Framework Reveals Region-Specific Cerebrovascular Remodeling in Aging Using Intravital Functional Ultrasound Imaging and Ultrasound Localization Microscopy (fUS-ULM). Adv Sci (Weinh):e10754, 2025 September, PMID: 40946188

Geng X, Chen L, Ahmed Z, Formigari GP, Ho YC, Del Gaudio I, Datilo MN, Azartash-Namin ZJ, Heron C, Shan X, Keshari RS, Pal S, Chen H, Lupu F, Xia L, Randolph GJ, Zawieja SD, Camerer E, Davis MJ, Srinivasan RS. S1PR1 regulates lymphatic valve development and tertiary lymphoid organ formation in the ileum. J Exp Med 222, 2025 September, PMID: 40553105, PMCID: PMC12187108

York LR, Ma H, Le Y, Griffin CT, Ding XQ. RIPK3 Contributes to Thyroid Hormone-Induced Photoreceptor Degeneration. Int J Mol Sci 26, 2025 August, PMID: 40943078, PMCID: PMC12428710

Rajala R, Griffin CT. Novel Function for Endothelial Protease-Activated Receptors in Modulating Insulin Receptor Activity With Implications for Diabetes. Arterioscler Thromb Vasc Biol, 2025 July, PMID: 40740132, PMCID: PMC12321246

Davis MJ, Castorena-Gonzalez JA, Li M, Simon AM, Srinivasan RS. Hierarchical requirement for endothelial cell connexins Cx37, Cx47, Cx43 and Cx45 in lymphatic valve function. Function (Oxf), 2025 July, PMID: 40720769, PMCID: PMC12448487

Bouhatous YM, Bredrup C, Maurer A, Mirakovska L, Foster A, Kosaki K, Jost C, Demoulin JB, Luu M, Vabres P, Kurtz JE, Schaefer E, Guimier A, Cormier-Daire V, Lim D, Thompson S, Olson L, Kwon HR, Aguirre-Rodriguez C, Hernandez-Dorronsoro U, Martinez-Soroa I, Iznardo H, Mascaró JM Jr, Baselga E, Kalantari S, Mussa A, Gazzin A, Carli D, Svinvik I, Mutlu-Albayrak H, Bluefeather S, Zarate Y, Takenouchi T, Naicker T, Chateau A, Gokhul A, Dube-Pule A, Haniffa M, Ong Peitee W, Nordgren A, Carpentier M, Binquet C, Briffaut AS, Bal L, Pond D, Rustad CF, Bardou M, Faivre L. 'Knowing and Treating Kosaki/Penttinen syndrome' international collaborative consortium: recommendations for follow-up, natural history and a real-life observational study about safety and efficacy profile of tyrosine kinase inhibitors. J Med Genet, 2025 July, PMID: 40707250

Lira AL, Puy C, Shatzel JJ, Lupu F, McCarty OJT. Bacterial infection and activation of the contact pathway of coagulation. Blood Vessel Thromb Hemost 2:100091, 2025 July, PMID: 40995104, PMCID: PMC12455109

Silasi R, Keshari RS, Abe T, Byrum SD, Regmi G, Lupu C, Georgescu C, Simmons JH, Shamanaev A, Moellmer SA, Puy C, Shatzel JJ, Province D, Edmondson RD, Mackintosh SG, Avaritt NL, Bloomfield D, Gailani D, Tackett AJ, McCarty OJT, Lupu F. Protective Effects of FXI Inhibition by Abelacimab in a Baboon Model of Live Staphylococcus aureus Sepsis. J Thromb Haemost, 2025 June, PMID: 40582699, PMCID: PMC12668790

Biswas I, Kudo M, Rezaie AR. Endothelial Protein C Receptor and Thrombomodulin Facilitate Protease-Activated Receptor 1 Cleavage at Arginine-46 by Thrombin and Activated Protein C. J Biol Chem:110339, 2025 June, PMID: 40480637, PMCID: PMC12269503

Tang Y, Song X, Zhang Z, Yao Y, Pan T, Qi J, Xia L, Wu D, Han Y. Hypermethylation of DNA impairs megakaryogenesis in delayed platelet recovery after allogeneic hematopoietic stem cell transplantation. Sci Adv 11:eads3630, 2025 May, PMID: 40333970, PMCID: PMC12057652

Han F, Simeroth S, Zhu J, Gryniuk I, Pranay A, Chen W, Wang Y, Cai Y, Shen Z, Wang G, Griffin CT, Xia L, Yu P. Lymphatic endothelial mTORC1 instructs metabolic and developmental signaling during lymphangiogenesis. Dev Cell, 2025 May, PMID: 40339577, PMCID: PMC12353337

Woods JP, Rackley A, Kwon HR, Olson LE. PDGFRα signaling regulates cartilage and fibrous tissue differentiation during synovial joint development. Nat Commun 16:4041, 2025 April, PMID: 40301343, PMCID: PMC12041487

Chandrakesan P, Yao J, Qu D, May R, Weygant N, Ge Y, Ali N, Sureban SM, Gude M, Vega K, Bannerman-Menson E, Xia L, Bronze M, An G, Houchen CW. Retraction Note: Dclk1, a tumor stem cell marker, regulates pro-survival signaling and self-renewal of intestinal tumor cells. Mol Cancer 24:120, 2025 April, PMID: 40253332, PMCID: PMC12008944

Rajala R, Griffin CT. A novel function for endothelial protease-activated receptors in modulating insulin receptor activity with implications for diabetes. bioRxiv, 2025 March, PMID: 40196641, PMCID: PMC11974755

Rajala R, Griffin CT. Kinome profiling: A veritable Rosetta stone for protease-activated receptor 1 biased signaling. Vascul Pharmacol:107469, 2025 February, PMID: 39904417, PMCID: PMC11890924

Rajala R, Griffin CT. Endothelial protease-activated receptor 4: impotent or important? Front Cardiovasc Med 12:1541879, 2025 January, PMID: 39935714, PMCID: PMC11810968

2024

Lira AL, Taskin B, Puy C, Keshari RS, Silasi R, Pang J, Aslan JE, Shatzel JJ, Lorentz CU, Tucker EI, Schmaier AH, Gailani D, Lupu F, McCarty OJT. The physicochemical properties of lipopolysaccharide chemotypes regulate activation of the contact pathway of blood coagulation. J Biol Chem:108110, 2024 December, PMID: 39706265, PMCID: PMC11773025

Biswas I, Panicker SR, Lupu F, Rezaie AR. Physiological significance of antithrombin D-helix interaction with vascular GAGs. Blood Adv, 2024 December, PMID: 39671300, PMCID: PMC11907474

Baeyens N, Coon BG, Mack JJ. Editorial: Mechanotransduction in vascular development and disease. Front Physiol 15:1525184, 2024 December, PMID: 39720312, PMCID: PMC11666544

Rajala R, Griffin CT. INTERCELLULAR SYNERGY BETWEEN PROTEASE-ACTIVATED RECEPTORS 1 AND 4 DURING MOUSE DEVELOPMENT. J Thromb Haemost, 2024 December, PMID: 39667689, PMCID: PMC11890951

Rajala R, Cleuren ACA, Griffin CT. Acetaminophen Overdose Reveals PAR4 as a Low-Expressing but Potent Receptor on the Hepatic Endothelium in Mice. Arterioscler Thromb Vasc Biol, 2024 October, PMID: 39360412, PMCID: PMC11668627

Chucair-Elliott AJ, Pham K, Cleuren ACA, Schafer CM, Griffin CT, Ocanas SR, Freeman WM, Elliott MH. Comparative Analysis of In vivo Endothelial Cell Translatomes Across Central Nervous System Vascular Beds. Exp Eye Res:110101, 2024 September, PMID: 39303842, PMCID: PMC11532013

Ma X, Wu W, Hara M, Zhou J, Panzarin C, Schafer CM, Griffin CT, Cai J, Ma JX, Takahashi Y. Deficient RPE mitochondrial energetics leads to subretinal fibrosis in age-related neovascular macular degeneration. Commun Biol 7:1075, 2024 September, PMID: 39223298, PMCID: PMC11369096

Nasuhidehnavi A, Zarzycka W, Górecki I, Chiao YA, Lee CF. Emerging interactions between mitochondria and NAD( ) metabolism in cardiometabolic diseases. Trends Endocrinol Metab, 2024 August, PMID: 39198117, PMCID: PMC11794032

Puy C, Moellmer SA, Pang J, Vu H, Melrose A, Lorentz CU, Tucker EI, Shatzel JJ, Keshari RS, Lupu F, Gailani D, McCarty OJT. Coagulation factor XI regulates endothelial cell permeability and barrier function in vitro and in vivo. Blood, 2024 August, PMID: 39158072, PMCID: PMC11830974

Riecan M, Domanska V, Lupu C, Patel M, Vondrackova M, Rossmeisl M, Saghatelian A, Lupu F, Kuda O. Tissue-specific sex-dependent difference in the metabolism of fatty acid esters of hydroxy fatty acids. Biochim Biophys Acta Mol Cell Biol Lipids:159543, 2024 August, PMID: 39097081

Szybowska PE, Nasuhidehnavi A, Lee CF. Heartbreak to Immune Breakdown: myocardial infarction is causing thymic injury mediated by activation of the hypothalamus-pituitary-adrenal axis. Am J Physiol Heart Circ Physiol, 2024 July, PMID: 39028278

Davis MJ, Castorena-Gonzalez JA, Li M, Zawieja SD, Simon AM, Geng X, Srinivasan RS. Connexin45 (GJC1) is expressed in mouse lymphatic endothelium and required for normal lymphatic valve function. JCI Insight, 2024 July, PMID: 39074069, PMCID: PMC11343601

Xia L. Gasdermin D and TMA. Blood 144:247-248, 2024 July, PMID: 39023873, PMCID: PMC11302444

Shan X, Rathore S, Kniffen D, Gao L, Nitin, Letef CL, Shi H, Ghosh S, Zandberg W, Xia L, Bergstrom KSB. Ablation of intestinal epithelial sialylation predisposes to acute and chronic intestinal inflammation in mice. Cell Mol Gastroenterol Hepatol:101378, 2024 July, PMID: 38992465, PMCID: PMC11459652

Shi H, Song J, Gao L, Shan X, Panicker SR, Yao L, McDaniel M, Zhou M, McGee S, Zhong H, Griffin CT, Xia L, Shao B. Deletion of Talin1 in Myeloid Cells Facilitates Atherosclerosis in Mice. Arterioscler Thromb Vasc Biol, 2024 June, PMID: 38899470

Wu ML, Wheeler K, Silasi R, Lupu F, Griffin CT. Endothelial Chromatin-Remodeling Enzymes Regulate the Production of Critical ECM Components During Murine Lung Development. Arterioscler Thromb Vasc Biol, 2024 June, PMID: 38868942, PMCID: PMC11624602

Nyúl-Tóth Á, Negri S, Sanford M, Jiang R, Patai R, Budda M, Petersen B, Pinckard J, Chandragiri SS, Shi H, Reyff Z, Ballard C, Gulej R, Csik B, Ferrier J, Balasubramanian P, Yabluchanskiy A, Cleuren A, Conley S, Ungvari Z, Csiszar A, Tarantini S. Novel intravital approaches to quantify deep vascular structure and perfusion in the aging mouse brain using ultrasound localization microscopy (ULM). J Cereb Blood Flow Metab:271678X241260526, 2024 June, PMID: 38867576, PMCID: PMC11542130

Rajala R, Cleuren ACA, Griffin CT. Acetaminophen Overdose Reveals Protease-Activated Receptor 4 as a Low-Expressing but Potent Receptor on the Hepatic Endothelium. bioRxiv, 2024 June, PMID: 38895465, PMCID: PMC11185779

Simeroth S, Yu P. The role of lymphatic endothelial cell metabolism in lymphangiogenesis and disease. Front Cardiovasc Med 11:1392816, 2024 May, PMID: 38798921, PMCID: PMC11119333

Aleman M, Arepally GM, Baglin T, Buitrago L, Davizon-Castillo P, Dayal S, Flick MJ, Gerber G, Hisada Y, Kolev K, O'Loghlen A, Rezaie AR, Sparkenbaugh EM, Stavrou EX, Ünlü B, Vercellotti GM. Coagulation and platelet biology at the intersection of health and disease: illustrated capsules of the 11th Symposium on Hemostasis at the University of North Carolina. Res Pract Thromb Haemost 8:102395, 2024 April, PMID: 38699410, PMCID: PMC11063502

Hatch CJ, Piombo SD, Fang JS, Gach JS, Ewald ML, Van Trigt WK, Coon BG, Tong JM, Forthal DN, Hughes CCW. SARS-CoV-2 infection of endothelial cells, dependent on flow-induced ACE2 expression, drives hypercytokinemia in a vascularized microphysiological system. Front Cardiovasc Med 11:1360364, 2024 March, PMID: 38576426, PMCID: PMC10991679

Yang J, Zhu L, Pan H, Ueharu H, Toda M, Yang Q, Hallett SA, Olson LE, Mishina Y. A BMP-controlled metabolic-epigenetic signaling cascade directs midfacial morphogenesis. J Clin Invest, 2024 March, PMID: 38466355, PMCID: PMC11014657

Zuo B, Yang F, Huang L, Han J, Li T, Ma Z, Cao L, Li Y, Bai X, Jiang M, He Y, Xia L. Endothelial Slc35a1 deficiency causes loss of LSEC identity and exacerbates neonatal lipid deposition in the liver in mice. Cell Mol Gastroenterol Hepatol, 2024 March, PMID: 38467191, PMCID: PMC11061248

Huang L, Kondo Y, Cao L, Han J, Li T, Zuo B, Yang F, Li Y, Ma Z, Bai X, Jiang M, Ruan C, Xia L. Novel GNE missense variants impair de novo sialylation and cause defective angiogenesis in the developing brain in mice. Blood Adv 8:991-1001, 2024 February, PMID: 38237079, PMCID: PMC10879683

Giri H, Biswas I, Rezaie AR. Thrombomodulin: A multifunctional receptor modulating the endothelial quiescence. J Thromb Haemost, 2024 January, PMID: 38266676, PMCID: PMC10960680

Boutagy NE, Gamez-Mendez A, Fowler JW, Zhang H, Chaube BK, Esplugues E, Lee S, Horikami D, Zhang J, Citrin KM, Singh AK, Coon BG, Suarez Y, Fernandez-Hernando C, Sessa WC. Dynamic metabolism of endothelial triglycerides protects against atherosclerosis in mice. J Clin Invest, 2024 January, PMID: 38175710, PMCID: PMC10866653

Biswas I, Giri H, Panicker SR, Rezaie AR. Thrombomodulin Switches Signaling and Protease-Activated Receptor 1 Cleavage Specificity of Thrombin. Arterioscler Thromb Vasc Biol, 2024 January, PMID: 38174561, PMCID: PMC10922642

2023

Shi H, Gao L, Kirby N, Shao B, Shan X, Kudo M, Silasi R, McDaniel MJ, Zhou M, McGee S, Jing W, Lupu F, Cleuren A, George JN, Xia L. Clearance of VWF by hepatic macrophages is critical for the protective effect of ADAMTS13 in sickle cell anemia mice. Blood, 2023 December, PMID: 38142410, PMCID: PMC10997916

Giri H, Biswas I, Rezaie AR. Thrombomodulin Regulates PTEN/AKT Signaling Axis in Endothelial Cells. Arterioscler Thromb Vasc Biol, 2023 December, PMID: 38059351, PMCID: PMC10841639

Pfeffer MA, Kohs TCL, Vu HH, Jordan KR, Si Han Wang J, Lorentz CU, Tucker EI, Puy C, Olson SR, DeLoughery TG, Hinds MT, Keshari RS, Gailani D, Lupu F, McCarty OJT, Shatzel JJ. Factor XI Inhibition for the Prevention of Catheter-Associated Thrombosis in Patients With Cancer Undergoing Central Line Placement: A Phase 2 Clinical Trial. Arterioscler Thromb Vasc Biol, 2023 November, PMID: 37970718, PMCID: PMC10877270

Riecan M, Domanska V, Lupu C, Patel M, Vondrackova M, Rossmeisl M, Saghatelian A, Lupu F, Kuda O. Tissue-specific sex difference in the metabolism of fatty acid esters of hydroxy fatty acids. bioRxiv, 2023 November, PMID: 38014093, PMCID: PMC10680750

Cleuren A, Molema G. Organotypic heterogeneity in microvascular endothelial cell responses in sepsis-a molecular treasure trove and pharmacological Gordian knot. Front Med (Lausanne) 10:1252021, 2023 November, PMID: 38020105, PMCID: PMC10665520

Subramani K, Bander J, Chen S, Suárez-Fariñas M, Venkatesan T, Subrahmanian S, Varshney R, Kini A, Sharma S, Rifkin DB, Cho J, Coller BS, Ahamed J. Evidence That Anemia Accelerates AS Progression Via Shear-Induced TGF-β1 Activation: Heyde's Syndrome Comes Full Circle. JACC Basic Transl Sci 9:185-199, 2023 November, PMID: 38510715, PMCID: PMC10950403

Wan Y, Adair K, Herrmann A, Shan X, Xia L, Duckworth CA, Yu LG. C1GalT1 expression reciprocally controls tumour cell-cell and tumour-macrophage interactions mediated by galectin-3 and MGL with double impact on cancer development and progression. Cell Death Dis 14:547, 2023 August, PMID: 37612278, PMCID: PMC10447578

Ho YC, Geng X, O'Donnell A, Ibarrola J, Fernandez-Celis A, Varshney R, Subramani K, Azartash-Namin ZJ, Kim J, Silasi R, Wylie-Sears J, Alvandi Z, Chen L, Cha B, Chen H, Xia L, Zhou B, Lupu F, Burkhart HM, Aikawa E, Olson LE, Ahamed J, López-Andrés N, Bischoff J, Yutzey KE, Srinivasan RS. PROX1 Inhibits PDGF-B Expression to Prevent Myxomatous Degeneration of Heart Valves. Circ Res, 2023 August, PMID: 37555328, PMCID: PMC10487359

Tong Y, Wu Y, Ma J, Ikeda M, Ide T, Griffin CT, Ding XQ, Wang S. Comparative mechanistic study of RPE cell death induced by different oxidative stresses. Redox Biol 65:102840, 2023 August, PMID: 37566944, PMCID: PMC10440584

Tsitsikov EN, Phan KP, Liu Y, Tsytsykova AV, Kinter M, Selland L, Garman L, Griffin C, Dunn IF. TRAF7 is an essential regulator of blood vessel integrity during mouse embryonic and neonatal development. iScience 26:107474, 2023 July, PMID: 37583551, PMCID: PMC10424150

Schafer CM, Martin-Almedina S, Kurylowicz K, Dufton N, Osuna-Almagro L, Wu ML, Johnson CF, Shah AV, Haskard DO, Buxton A, Willis E, Wheeler K, Turner S, Chlebicz M, Scott RP, Kovats S, Cleuren A, Birdsey GM, Randi AM, Griffin CT. Cytokine-Mediated Degradation of the Transcription Factor ERG Impacts the Pulmonary Vascular Response to Systemic Inflammatory Challenge. Arterioscler Thromb Vasc Biol, 2023 June, PMID: 37317853, PMCID: PMC10364964

Jiang M, Yang F, Jiang Y, Cheng L, Han J, Yi J, Zuo B, Huang L, Ma Z, Li T, Cao L, Xia Z, Bai X, Jia C, Yang TTC, Esmon NL, Ruan C, Xia L, Esmon C, Han Y, Wu D, Xu J. Safety and efficacy of anti-human activated protein C antibody SR604 for prophylaxis of congenital factor deficiencies. Blood, 2023 June, PMID: 37294924

Chella Krishnan K, El Hachem EJ, Keller MP, Patel SG, Carroll L, Vegas AD, Gerdes Gyuricza I, Light C, Cao Y, Pan C, Kaczor-Urbanowicz KE, Shravah V, Anum D, Pellegrini M, Lee CF, Seldin MM, Rosenthal NA, Churchill GA, Attie AD, Parker B, James DE, Lusis AJ. Genetic architecture of heart mitochondrial proteome influencing cardiac hypertrophy. Elife 12, 2023 June, PMID: 37276142, PMCID: PMC10241513

Dragomir MP, Fuentes-Mattei E, Winkle M, Okubo K, Bayraktar R, Knutsen E, Qdaisat A, Chen M, Li Y, Shimizu M, Pang L, Liu K, Liu X, Anfossi S, Zhang H, Koch I, Tran AM, Mohapatra S, Ton A, Kaplan M, Anderson MW, Rothfuss SJ, Silasi R, Keshari RS, Ferracin M, Ivan C, Rodriguez-Aguayo C, Lopez-Berestein G, Georgescu C, Banerjee PP, Basar R, Li Z, Horst D, Vasilescu C, Bertilaccio MTS, Rezvani K, Lupu F, Yeung SC, Calin GA. Anti-miR-93-5p therapy prolongs sepsis survival by restoring the peripheral immune response. J Clin Invest, 2023 June, PMID: 37261908, PMCID: PMC10348769

Elhadad S, Redmond D, Tan A, Huang J, Rodriguez BL, Racine-Brzostek SE, Subrahmanian S, Ahamed J, Laurence J. Defibrotide mitigates endothelial cell injury induced by plasmas from patients with COVID-19 and related vasculopathies. Thromb Res 225:47-56, 2023 March, PMID: 37001283, PMCID: PMC10033153

Giri H, Biswas I, Rezaie AR. Activated protein C inhibits mesothelial-to-mesenchymal transition in experimental peritoneal fibrosis. J Thromb Haemost 21:133-144, 2023 January, PMID: 36695376, PMCID: PMC10726528

2022

Li P, Newhardt MF, Matsuzaki S, Eyster C, Pranay A, Peelor FF 3rd, Batushansky A, Kinter C, Subramani K, Subrahmanian S, Ahamed J, Yu P, Kinter M, Miller BF, Humphries KM. The loss of cardiac SIRT3 decreases metabolic flexibility and proteostasis in an age-dependent manner. Geroscience, 2022 December, PMID: 36460774, PMCID: PMC9886736

Tsai K, Ma C, Han X, Allaire J, Healey GR, Crowley SM, Yu H, Jacobson K, Xia L, Priatel JJ, Vallance BA. HIGHLY SENSITIVE, FLOW CYTOMETRY-BASED MEASUREMENT OF INTESTINAL PERMEABILITY IN MODELS OF EXPERIMENTAL COLITIS. Cell Mol Gastroenterol Hepatol, 2022 October, PMID: 36244647, PMCID: PMC9791122

Mahamud MR, Geng X, Chen L, Ahmed Z, Ho Y, Srinivasan RS. GATA2 regulates blood/lymph separation in a platelet-dependent and lymphovenous valve-independent manner. Microcirculation:e12787, 2022 October, PMID: 36197446, PMCID: PMC10073350

Iwayama T, Iwashita M, Miyashita K, Sakashita H, Matsumoto S, Tomita K, Bhongsatiern P, Kitayama T, Ikegami K, Shimbo T, Tamai K, Murayama MA, Ogawa S, Iwakura Y, Yamada S, Olson LE, Takedachi M, Murakami S. Plap-1 lineage tracing and single-cell transcriptomics reveal cellular dynamics in the periodontal ligament. Development 149, 2022 October, PMID: 36245218

Nizami HL, Minor KE, Chiao YA, Light CM, Lee CF. Sexually Dimorphic Effects of SARM1 Deletion on Cardiac NAD Metabolism and Function. Am J Physiol Heart Circ Physiol, 2022 September, PMID: 36053750, PMCID: PMC9529255

Shi H, Shao B, Gao L, Venkatesan T, McDaniel JM, Zhou M, McGee S, Yu P, Ahamed J, Journeycake J, George JN, Xia L. Endothelial VWF is critical for the pathogenesis of vaso-occlusive episode in a mouse model of sickle cell disease. Proc Natl Acad Sci U S A 119:e2207592119, 2022 August, PMID: 35969769, PMCID: PMC9407592

Yao L, Rathnakar BH, Kwon HR, Sakashita H, Kim JH, Rackley A, Tomasek JJ, Berry WL, Olson LE. Temporal control of PDGFRα regulates the fibroblast-to-myofibroblast transition in wound healing. Cell Rep 40:111192, 2022 August, PMID: 35977484, PMCID: PMC9423027

Ahamed J, Laurence J. Long COVID endotheliopathy: hypothesized mechanisms and potential therapeutic approaches. J Clin Invest 132, 2022 August, PMID: 35912863, PMCID: PMC9337829

Kemp SS, Penn MR, Koller GM, Griffin CT, Davis GE. Proinflammatory mediators, TNFα, IFNγ, and thrombin, directly induce lymphatic capillary tube regression. Front Cell Dev Biol 10:937982, 2022 July, PMID: 35927983, PMCID: PMC9343954

Geng X, Srinivasan RS. Molecular Mechanisms Driving Lymphedema and Other Lymphatic Anomalies. Cold Spring Harb Perspect Med, 2022 July, PMID: 35817543, PMCID: PMC9341459

Ariëns RA, Hunt BJ, Agbani EO, Ahnström J, Ahrends R, Alikhan R, Assinger A, Bagoly Z, Balduini A, Barbon E, Barrett CD, Batty P, Carneiro JDA, Chan WS, de Maat M, de Wit K, Denis C, Ellis MH, Eslick R, Fu H, Hayward CPM, Ho-Tin-Noé B, Klok FA, Kumar R, Leiderman K, Litvinov RI, Mackman N, McQuilten Z, Neal MD, Parker WAE, Preston RJS, Rayes J, Rezaie AR, Roberts LN, Rocca B, Shapiro S, Siegal DM, Sousa LP, Suzuki-Inoue K, Zafar T, Zhou J. Illustrated State-of-the-Art Capsules of the ISTH 2022 Congress. Res Pract Thromb Haemost 6:e12747, 2022 July, PMID: 35814801, PMCID: PMC9257378

Gostynska S, Venkatesan T, Subramani K, Cortez B, Robertson A, Subrahmanian S, Dube P, Ahamed J. Megakaryocyte/platelet-derived TGF-β1 inhibits megakaryopoiesis in bone marrow by regulating thrombopoietin production in liver. Blood Adv 6:3321-3328, 2022 June, PMID: 35358295, PMCID: PMC9198906

Elhadad S, Chadburn A, Magro C, Van Besien K, Roberson EDO, Atkinson JP, Terry H, Greenberg J, Reid W, Chapin J, Copertino D, Geramfard S, Rodriguez LB, Orfali N, Gerghis U, Shore T, Mayer S, Ahamed J, Laurence J. C5b-9 and MASP2 deposition in skin and bone marrow microvasculature characterize hematopoietic stem cell transplant-associated thrombotic microangiopathy. Bone Marrow Transplant, 2022 June, PMID: 35661836

Laurence J, Nuovo G, Racine-Brzostek SE, Seshadri M, Elhadad S, Crowson AN, Mulvey JJ, Harp J, Ahamed J, Magro C. Pre-mortem skin biopsy assessing microthrombi, interferon-I antiviral and regulatory proteins, and complement deposition correlates with COVID-19 clinical stage. Am J Pathol, 2022 May, PMID: 35640675, PMCID: PMC9144849

Shao B, Nusrat S, George JN, Xia L. Aspirin Prophylaxis for Hereditary and Acquired Thrombotic Thrombocytopenic Purpura? Am J Hematol, 2022 May, PMID: 35593427, PMCID: PMC9262856

Van der Ent MA, Svilar D, Cleuren ACA. Molecular analysis of vascular gene expression. Res Pract Thromb Haemost 6:e12718, 2022 May, PMID: 35599705, PMCID: PMC9118339

de Castro RO, Carbajal A, Previato de Almeida L, Goitea V, Griffin CT, Pezza RJ. Mouse Chd4-NURD is required for neonatal spermatogonia survival and normal gonad development. Epigenetics Chromatin 15:16, 2022 May, PMID: 35568926, PMCID: PMC9107693

Chakraborty A, Minor KE, Nizami HL, Chiao YA, Lee CF. Harnessing NAD Metabolism as Therapy for Cardiometabolic Diseases. Curr Heart Fail Rep, 2022 May, PMID: 35556214, PMCID: PMC9339518

Lee CF. Regulation of NAD Metabolism in Diastolic Dysfunction Induced by Metabolic Stress. FASEB J 36 Suppl 1, 2022 May, PMID: 35554201

Lee CF, Nizami H, Gu H, Light C. SARM1 NAD Hydrolase Deficiency Normalizes Fibrosis and Ameliorates Cardiac Dysfunction in Diabetic Hearts. FASEB J 36 Suppl 1, 2022 May, PMID: 35555837

Jiang M, Yang F, Jiang Y, Cheng L, Han J, Yi J, Zhang G, Ma Z, Cao L, Zuo B, Zhou L, Huang L, Niu S, Xia Z, Zhou X, Bai X, Esmon NL, Ruan C, Xia L, Han Y, Esmon C, Wu D, Xu J. Blocking human protein C anticoagulant activity improves clotting defects of hemophilia mice expressing human protein C. Blood Adv, 2022 April, PMID: 35390147, PMCID: PMC9198932

Chaaban H, Patel MM, Burge K, Eckert JV, Lupu C, Keshari RS, Silasi R, Regmi G, Trammell M, Dyer D, McElroy SJ, Lupu F. Early Antibiotic Exposure Alters Intestinal Development and Increases Susceptibility to Necrotizing Enterocolitis: A Mechanistic Study. Microorganisms 10, 2022 February, PMID: 35336095, PMCID: PMC8951210

Shao B, Hoover CM, Shi H, Kondo Y, Lee RH, Chen J, Shan X, Song J, McDaniel M, Zhou M, McGee S, Vanhoorelbeke K, Bergmeier W, López JA, George JN, Xia L. Deletion of platelet CLEC-2 decreases GPIba-mediated integrin aIIbb3 activation and decreases thrombosis in TTP. Blood, 2022 February, PMID: 35157766, PMCID: PMC9029097

Menendez M, Drozd A, Borawska K, Chmielewska JJ, Wu ML, Griffin CT. IL-1β Impacts Vascular Integrity and Lymphatic Function in the Embryonic Omentum. Circ Res, 2022 January, PMID: 34986653, PMCID: PMC8813910

Geng X, Chen L, Srinivasan RS, Kylat RJ, Witte MH, Erickson RJ. Lack of embryonic homozygous or adult heterozygous lymphatic phenotypes for a Sos1 mutation and lack of lymphatic embryonic phenotypes for a homozygous Cx47 mutation in mice. Lymphology 55:129-134, 2022 January, PMID: 36446400, PMCID: PMC10583265

Bergstrom K, Xia L. The barrier and beyond: Roles of intestinal mucus and mucin-type O-glycosylation in resistance and tolerance defense strategies guiding host-microbe symbiosis. Gut Microbes 14:2052699, 2022 January, PMID: 35380912, PMCID: PMC8986245

2021

Ren D, Fedorova J, Davitt K, Le TNV, Griffin JH, Liaw PC, Esmon C, Rezaie AR, Li J. Activated Protein C Strengthens Cardiac Tolerance to Ischemic Insults in Aging. Circ Res, 2021 December, PMID: 34930019, PMCID: PMC8882057

Jiang Y, Tang Y, Hoover C, Kondo Y, Huang D, Restagno D, Shao B, Gao L, Michael McDaniel J, Zhou M, Silasi-Mansat R, McGee S, Jiang M, Bai X, Lupu F, Ruan C, Marth JD, Wu D, Han Y, Xia L. Kupffer cell receptor CLEC4F is important for the destruction of desialylated platelets in mice. Cell Death Differ, 2021 November, PMID: 33993195, PMCID: PMC8564511

Biswas I, Panicker SR, Giri H, Cai XS, Rezaie AR. Antithrombin protects against Plasmodium falciparum histidine-rich protein II-mediated inflammation and coagulation. Blood Adv, 2021 November, PMID: 34768285, PMCID: PMC8945290

Kwon HR, Kim JH, Woods JP, Olson LE. Skeletal stem cell fate defects caused by Pdgfrb activating mutation. Development, 2021 November, PMID: 34738614, PMCID: PMC8714075

Biswas I, Panicker SR, Cai XS, Giri H, Rezaie AR. Extracellular Histones Bind Vascular Glycosaminoglycans and Inhibit the Anti-Inflammatory Function of Antithrombin. Cell Physiol Biochem 55:605-617, 2021 October, PMID: 34655467, PMCID: PMC8552502

Subrahmanian S, Varshney R, Subramani K, Murphy B, Woolington S, Ahamed J. N-acetylcysteine inhibits aortic stenosis progression in a murine model by blocking shear-induced activation of platelet latent TGF-β1. Antioxid Redox Signal, 2021 October, PMID: 34619980

Tang C, Wang L, Sheng Y, Zheng Z, Xie Z, Wu F, You T, Ren L, Xia L, Ruan C, Zhu L. CLEC-2-dependent platelet subendothelial accumulation by flow disturbance contributes to atherogenesis in mice. Theranostics 11:9791-9804, 2021 October, PMID: 34815786, PMCID: PMC8581433

Lin PK, Salvador J, Xie J, Aguera KN, Koller GM, Kemp SS, Griffin CT, Davis GE. Selective and marked blockade of endothelial sprouting behavior using paclitaxel and related pharmacologic agents. Am J Pathol, 2021 September, PMID: 34563512, PMCID: PMC8647436

Keshari RS, Popescu NI, Silasi R, Regmi G, Lupu C, Simmons JH, Ricardo A, Coggeshall KM, Lupu F. Complement C5 inhibition protects against hemolytic anemia and acute kidney injury in anthrax peptidoglycan-induced sepsis in baboons. Proc Natl Acad Sci U S A 118, 2021 September, PMID: 34507997, PMCID: PMC8449412

Song H, Zhu J, Li P, Han F, Fang L, Yu P. Metabolic flexibility maintains proliferation and migration of FGFR signaling-deficient lymphatic endothelial cells. J Biol Chem :101149, 2021 August, PMID: 34473994, PMCID: PMC8498002

Popescu NI, Lupu C, Lupu F. Disseminated intravascular coagulation and its immune mechanisms. Blood, 2021 August, PMID: 34428280, PMCID: PMC8972096

Chaftari P, Qdaisat A, Chaftari AM, Maamari J, Li Z, Lupu F, Raad I, Hachem R, Calin G, Yeung SJ. Prognostic Value of Procalcitonin, C-Reactive Protein, and Lactate Levels in Emergency Evaluation of Cancer Patients with Suspected Infection. Cancers (Basel) 13, 2021 August, PMID: 34439240, PMCID: PMC8393196

Chiao YA, Chakraborty AD, Light CM, Tian R, Sadoshima J, Shi X, Gu H, Lee CF. NAD Redox Imbalance in the Heart Exacerbates Diabetic Cardiomyopathy. Circ Heart Fail:CIRCHEARTFAILURE120008170, 2021 August, PMID: 34374300

Kondo Y, Larabee JL, Gao L, Shi H, Shao B, Hoover CM, McDaniel JM, Ho YC, Silasi-Mansat R, Archer-Hartmann SA, Azadi P, Srinivasan RS, Rezaie AR, Borczuk A, Laurence JC, Lupu F, Ahamed J, McEver RP, Papin JF, Yu Z, Xia L. L-SIGN is a receptor on liver sinusoidal endothelial cells for SARS-CoV-2 virus. JCI Insight 6, 2021 July, PMID: 34291736, PMCID: PMC8410055

Lu Y, Villoutreix BO, Biswas I, Ding Q, Wang X, Rezaie AR. Antithrombin Resistance Rescues Clotting Defect of Homozygous Prothrombin-Y510N Dysprothrombinemia. Thromb Haemost, 2021 July, PMID: 34256393, PMCID: PMC8755856

Geng X, Ho YC, Srinivasan RS. Biochemical and mechanical signals in the lymphatic vasculature. Cell Mol Life Sci, 2021 July, PMID: 34240226

Subrahmanian S, Borczuk A, Salvatore S, Fung KM, Merrill JT, Laurence J, Ahamed J. Tissue Factor upregulation is associated with SARS-CoV-2 in the lungs of COVID-19 patients. J Thromb Haemost, 2021 July, PMID: 34236752, PMCID: PMC8565501

Gao S, Menendez M, Kurylowicz K, Griffin CT. Genomic locus proteomic screening identifies the NF-κB signaling pathway components NFκB1 and IKBKG as transcriptional regulators of Ripk3 in endothelial cells. PLoS One 16:e0253519, 2021 June, PMID: 34153072, PMCID: PMC8216549

Zhou L, Yu T, Yang F, Han J, Zuo B, Huang L, Bai X, Jiang M, Wu D, Chen S, Xia L, Ruan J, Ruan C. G Protein-Coupled Estrogen Receptor Agonist G-1 Inhibits Mantle Cell Lymphoma Growth in Preclinical Models. Front Oncol 11:668617, 2021 June, PMID: 34211844, PMCID: PMC8239310

Chaaban H, Burge K, Eckert J, Trammell M, Dyer D, Keshari RS, Silasi R, Regmi G, Lupu C, Good M, McElroy SJ, Lupu F. Acceleration of Small Intestine Development and Remodeling of the Microbiome Following Hyaluronan 35 kDa Treatment in Neonatal Mice. Nutrients 13, 2021 June, PMID: 34204790, PMCID: PMC8231646

Woods JP, Srinivasan RS, Olson LE. Sweet Dre-ams about intersectional genetics. Cell Stem Cell 28:989-990, 2021 June, PMID: 34087159

Hoover CM, Kondo Y, Shao B, McDaniel M, Lee R, McGee S, Whiteheart SW, Bergmeier W, McEver RP, Xia L. Heightened activation of embryonic megakaryocytes causes aneurysms in the developing brain of mice lacking podoplanin. Blood, 2021 May, PMID: 33619517, PMCID: PMC8138551

Lupu C, Patel MM, Lupu F. Insights into the Functional Role of ADTRP (Androgen-Dependent TFPI-Regulating Protein) in Health and Disease. Int J Mol Sci 22, 2021 April, PMID: 33923232, PMCID: PMC8123165

Puy C, Pang J, Reitsma SE, Lorentz CU, Tucker EI, Gailani D, Gruber A, Lupu F, McCarty OJT. Cross-Talk between the Complement Pathway and the Contact Activation System of Coagulation: Activated Factor XI Neutralizes Complement Factor H. J Immunol 206:1784-1792, 2021 April, PMID: 33811105, PMCID: PMC8030746

Giri H, Panicker SR, Cai X, Biswas I, Weiler H, Rezaie AR. Thrombomodulin is essential for maintaining quiescence in vascular endothelial cells. Proc Natl Acad Sci U S A 118, 2021 March, PMID: 33836597, PMCID: PMC7980409

Lu Y, Biswas I, Villoutreix BO, Rezaie AR. Role of Gly197 in the structure and function of protein C. Biochim Biophys Acta Gen Subj:129892, 2021 March, PMID: 33722640, PMCID: PMC8052293

Cai X, Panicker SR, Biswas I, Giri H, Rezaie AR. Protective Role of Activated Protein C against Viral Mimetic Poly(I:C)-Induced Inflammation. Thromb Haemost, 2021 March, PMID: 33706396, PMCID: PMC8433266

Nandadasa S, O'Donnell A, Murao A, Yamaguchi Y, Midura RJ, Olson L, Apte SS. The versican-hyaluronan complex provides an essential extracellular matrix niche for Flk1(+) hematoendothelial progenitors. Matrix Biol 97:40-57, 2021 March, PMID: 33454424, PMCID: PMC8039968

Ma X, Li Y, Kondo Y, Shi H, Han J, Jiang Y, Bai X, Archer-Hartmann SA, Azadi P, Ruan C, Fu J, Xia L. Slc35a1 deficiency causes thrombocytopenia due to impaired megakaryocytopoiesis and excessive platelet clearance in the liver. Haematologica 106:759-769, 2021 March, PMID: 32303557, PMCID: PMC7927894

Silasi R, Keshari RS, Regmi G, Lupu C, Georgescu C, Simmons JH, Wallisch M, Kohs TCL, Shatzel JJ, Olson SR, Lorentz C, Puy C, Tucker EI, Gailani D, Strickland S, Gruber A, McCarty O, Lupu F. Factor XII plays a pathogenic role in organ failure and death in baboons challenged with Staphylococcus aureus. Blood, 2021 February, PMID: 33598692, PMCID: PMC8288658

Gao S, Griffin CT. RIPK3 modulates growth factor receptor expression in endothelial cells to support angiogenesis. Angiogenesis, 2021 January, PMID: 33449298, PMCID: PMC8280251

2020

Seshadri M, Ahamed J, Laurence J. Intervention in COVID-19 linked hypercoaguable states characterized by circuit thrombosis utilizing a direct thrombin inhibitor. Thromb Update 1:100009, 2020 December, PMID: 38620488, PMCID: PMC7476895

Keshari RS, Silasi R, Popescu NI, Regmi G, Chaaban H, Lambris JD, Lupu C, Mollnes TE, Lupu F. CD14 inhibition improves survival and attenuates thrombo-inflammation and cardiopulmonary dysfunction in a baboon model of Escherichia coli sepsis. J Thromb Haemost, 2020 November, PMID: 33174372, PMCID: PMC8312235

Chen D, Geng X, Lapinski PE, Davis MJ, Srinivasan RS, King PD. RASA1-driven cellular export of collagen IV is required for the development of lymphovenous and venous valves in mice. Development, 2020 November, PMID: 33144395, PMCID: PMC7746672

Bergstrom K, Shan X, Casero D, Batushansky A, Lagishetty V, Jacobs JP, Hoover C, Kondo Y, Shao B, Gao L, Zandberg W, Noyovitz B, McDaniel JM, Gibson DL, Pakpour S, Kazemian N, McGee S, Houchen CW, Rao CV, Griffin TM, Sonnenburg JL, McEver RP, Braun J, Xia L. Proximal colon-derived O-glycosylated mucus encapsulates and modulates the microbiota. Science 370:467-472, 2020 October, PMID: 33093110, PMCID: PMC8132455

Cha B, Ho YC, Geng X, Mahamud MR, Chen L, Kim Y, Choi D, Kim TH, Randolph GJ, Cao X, Chen H, Srinivasan RS. YAP and TAZ maintain PROX1 expression in the developing lymphatic and lymphovenous valves in response to VEGF-C signaling. Development, 2020 October, PMID: 33060128, PMCID: PMC7758626

Schafer CM, Gurley JM, Kurylowicz K, Lin PK, Chen W, Elliott MH, Davis GE, Bhatti F, Griffin CT. An inhibitor of endothelial ETS transcription factors promotes physiologic and therapeutic vessel regression. Proc Natl Acad Sci U S A, 2020 October, PMID: 33020273, PMCID: PMC7584886

Song K, Cai X, Dong Y, Wu H, Wei Y, Shankavaram U, Cui K, Lee Y, Zhu B, Bhattacharjee S, Wang B, Zhang K, Wen A, Wong S, Yu L, Xia L, Welm AL, Bielenberg DR, Camphausen K, Kang Y, Chen H. Epsins 1 and 2 promote NEMO linear ubiquitination via LUBAC to drive breast cancer development. J Clin Invest, 2020 September, PMID: 32960814, PMCID: PMC7773373

Lupu F, Kinasewitz G, Dormer K. The role of endothelial shear stress on haemodynamics, inflammation, coagulation and glycocalyx during sepsis. J Cell Mol Med, 2020 September, PMID: 32951280, PMCID: PMC7687012

Ahamed J. Severe aortic stenosis patient risk during the COVID-19 pandemic. Open Heart 7, 2020 September, PMID: 32928913, PMCID: PMC7490908

Rezaie AR, Giri H. Anticoagulant and signaling functions of antithrombin. J Thromb Haemost, 2020 August, PMID: 32780936, PMCID: PMC7855051

Madhusudhan T, Ghosh S, Wang H, Dong W, Gupta D, Elwakiel A, Stoyanov S, Al-Dabet MM, Krishnan S, Biemann R, Nazir S, Zimmermann S, Mathew A, Gadi I, Rana R, Zeng-Brouwers J, Moeller MJ, Schaefer L, Esmon CT, Kohli S, Reiser J, Rezaie AR, Ruf W, Isermann B. Podocyte Integrin-β 3 and Activated Protein C Coordinately Restrict RhoA Signaling and Ameliorate Diabetic Nephropathy. J Am Soc Nephrol, 2020 July, PMID: 32709711, PMCID: PMC7460917

Elhadad S, Chapin J, Copertino D, Van Besien K, Ahamed J, Laurence J. MASP2 levels are elevated in thrombotic microangiopathies: Association with microvascular endothelial cell injury and suppression by anti-MASP2 antibody narsoplimab. Clin Exp Immunol, 2020 July, PMID: 32681658, PMCID: PMC7405159

Xie J, Gao S, Schafer C, Colijn S, Muthukumar V, Griffin CT. The chromatin-remodeling enzyme CHD3 plays a role in embryonic viability but is dispensable for early vascular development. PLoS One 15:e0235799, 2020 July, PMID: 32658897, PMCID: PMC7357745

Popescu NI, Keshari RS, Cochran J, Coggeshall KM, Lupu F. C3 Opsonization of Anthrax Bacterium and Peptidoglycan Supports Recognition and Activation of Neutrophils. Microorganisms 8, 2020 July, PMID: 32668703, PMCID: PMC7409185

Xie Z, Shao B, Hoover C, McDaniel M, Song J, Jiang M, Ma Z, Yang F, Han J, Bai X, Ruan C, Xia L. Monocyte upregulation of podoplanin during early sepsis induces complement inhibitor release to protect liver function. JCI Insight 5, 2020 July, PMID: 32641582, PMCID: PMC7406268

Lu Y, Villoutreix BO, Biswas I, Ding Q, Wang X, Rezaie AR. Thr90Ser Mutation in Antithrombin is Associated with Recurrent Thrombosis in a Heterozygous Carrier. Thromb Haemost 120:1045-1055, 2020 July, PMID: 32422680, PMCID: PMC7444675

Avery EJ, Kenney SP, Byers BD, McIntosh JJ, Hoover C, Jiang Y, Xia L, Yu Z, George JN. Thrombotic Thrombocytopenic Purpura Masquerading as Preeclampsia With Severe Features at 13 Weeks' Gestation. Am J Hematol, 2020 June, PMID: 32602158, PMCID: PMC7770040

Geng X, Yanagida K, Akwii RG, Choi D, Chen L, Ho Y, Cha B, Mahamud MR, Berman de Ruiz K, Ichise H, Chen H, Wythe J, Mikelis CM, Hla T, Srinivasan RS. S1PR1 regulates the quiescence of lymphatic vessels by inhibiting laminar shear stress-dependent VEGF-C signaling. JCI Insight, 2020 June, PMID: 32544090, PMCID: PMC7453895

Chaaban H, Burge K, Eckert J, Keshari RS, Silasi R, Lupu C, Warner B, Escobedo M, Caplan M, Lupu F. Neutrophil extracellular trap inhibition increases inflammation, bacteraemia and mortality in murine necrotizing enterocolitis. J Cell Mol Med, 2020 June, PMID: 32515131

Panicker SR, Biswas I, Giri H, Cai X, Rezaie AR. PKC (Protein Kinase C)-δ Modulates AT (Antithrombin) Signaling in Vascular Endothelial Cells. Arterioscler Thromb Vasc Biol:ATVBAHA120314479, 2020 May, PMID: 32404004, PMCID: PMC7316612

Castorena-Gonzalez JA, Srinivasan RS, King PD, Simon AM, Davis MJ. Simplified method to quantify valve back-leak uncovers severe mesenteric lymphatic valve dysfunction in mice deficient in connexins 43 and 37. J Physiol, 2020 April, PMID: 32267537

Jiang Y, Huang D, Kondo Y, Jiang M, Ma Z, Zhou L, Su J, Bai X, Ruan C, Wang Z, Xia L. Novel mutations in ADAMTS13 CUB domains cause abnormal pre-mRNA splicing and defective secretion of ADAMTS13. J Cell Mol Med 24:4356-4361, 2020 April, PMID: 32073234, PMCID: PMC7171419

Sun C, Sakashita H, Kim J, Tang Z, Upchurch GM, Yao L, Berry WL, Griffin TM, Olson LE. Mosaic Mutant Analysis Identifies PDGFRα/PDGFRβ as Negative Regulators of Adipogenesis. Cell Stem Cell, 2020 March, PMID: 32229310, PMCID: PMC7214206

Medley SC, Rathnakar BH, Georgescu C, Wren JD, Olson LE. Fibroblast-specific Stat1 deletion enhances the myofibroblast phenotype during tissue repair. Wound Repair Regen, 2020 March, PMID: 32175700, PMCID: PMC7321860

Laurence J, Elhadad S, Gostynska S, Yu Z, Terry H, Varshney R, Fung KM, Choi ME, Ahamed J. HIV protease inhibitor ritonavir induces renal fibrosis and dysfunction: role of platelet-derived TGF-β1 and intervention via anti-oxidant pathways. AIDS, 2020 March, PMID: 32167970, PMCID: PMC7210074

Rezaie AR, Giri H. Antithrombin: An anticoagulant, anti-inflammatory and antibacterial serpin. J Thromb Haemost 18:528-533, 2020 March, PMID: 32112532, PMCID: PMC7080319

Gyulkhandanyan A, Rezaie AR, Roumenina L, Lagarde N, Fremeaux-Bacchi V, Miteva MA, Villoutreix BO. Analysis of protein missense alterations by combining sequence- and structure-based methods. Mol Genet Genomic Med:e1166, 2020 February, PMID: 32096919, PMCID: PMC7196459

Lu Y, Giri H, Villoutreix BO, Ding Q, Wang X, Rezaie AR. Gly197Arg mutation in protein C causes recurrent thrombosis in a heterozygous carrier. J Thromb Haemost, 2020 February, PMID: 32078247, PMCID: PMC7192786

Ho YC, Srinivasan RS. Lymphatic Vasculature in Energy Homeostasis and Obesity. Front Physiol 11:3, 2020 January, PMID: 32038308, PMCID: PMC6987243

Colijn S, Muthukumar V, Xie J, Gao S, Griffin CT. Cell-specific and athero-protective roles for RIPK3 in a murine model of atherosclerosis. Dis Model Mech, 2020 January, PMID: 31953345, PMCID: PMC6994951

Buhl EM, Djudjaj S, Klinkhammer BM, Ermert K, Puelles VG, Lindenmeyer MT, Cohen CD, He C, Borkham-Kamphorst E, Weiskirchen R, Denecke B, Trairatphisan P, Saez-Rodriguez J, Huber TB, Olson LE, Floege J, Boor P. Dysregulated mesenchymal PDGFR-β drives kidney fibrosis. EMBO Mol Med:e11021, 2020 January, PMID: 31943786, PMCID: PMC7059015

Yan B, Wang Q, Du W, Zhai S, Gou C, Hu T, Xia L, Ruan C, Zhao Y. Elevated Plasma von Willebrand Factor Antigen and Activity Levels Are Associated With the Severity of Coronary Stenosis. Clin Appl Thromb Hemost 26:1076029619900552, 2020 January, PMID: 31964151, PMCID: PMC7098204

Cardiovascular Biology Research Program
Oklahoma Medical Research Foundation
825 NE 13th Street, MS 45
Oklahoma City, OK 73104

Phone: (405) 271-6480
Fax: (405) 271-3137
Email:  Mia-Pederson-Rambo@omrf.org