2003 Scientific Publications
Arthritis Research Program
Arbuckle,M.R., J.A.James, G.J.Dennis, M.V.Rubertone, M.T.McClain, X.R.Kim, and J.B.Harley. 2003. Rapid clinical progression to diagnosis among African-American men with systemic lupus erythematosus. Lupus 12:99-106. [Abstract]
Arbuckle,M.R., M.T.McClain, M.V.Rubertone, R.H.Scofield, G.J.Dennis, J.A.James, and J.B.Harley. 2003. Development of autoantibodies before the clinical onset of systemic lupus erythematosus. N.Engl.J Med. 349:1526-1533. [Abstract]
Aringer,M., S.R.Hofmann, D.M.Frucht, M.Chen, M.Centola, A.Morinobu, R.Visconti, D.L.Kastner, J.S.Smolen, and J.J.O’Shea. 2003. Characterization and analysis of the proximal Janus Kinase 3 promoter. J Immunol. 170:6057-6064. [Abstract]
Aston,C.E. 2003. Reply to AP Polednak. Am.J Clin.Nutr. 77:1528.
Astrom,K., J.E.Cohen, J.E.Willett-Brozick, C.E.Aston, and B.E.Baysal. 2003. Altitude is a phenotypic modifier in hereditary paraganglioma type 1: evidence for an oxygen-sensing defect. Hum.Genet. 113:228-37. [Abstract
Burch,J.M., R.J.Sokol, M.R.Narkewicz, M.Reichlin, M.B.Frank, T.MacKenzie, and L.A.Lee. 2003. Autoantibodies in mothers of children with neonatal liver disease. J Pediatr.Gastroenterol.Nutr. 37:262-267. [Abstract]
Dozmorov,I. and M.Centola. 2003. An associative analysis of gene expression array data. Bioinformatics. 19:204-211. [Abstract]
Dozmorov,I., M.R.Saban, N.P.Gerard, B.Lu, N.B.Nguyen, M.Centola, and R.Saban. 2003. Neurokinin 1 receptors and neprilysin modulation of mouse bladder gene-regulation. Physiol Genomics 12: 239-250. [Abstract]
Dozmorov,I., M.R.Saban, N.Knowlton, M.Centola, and R.Saban. 2003. Connective molecular pathways of experimental bladder inflammation. Physiol Genomics 15:209-222. [Abstract]
Foster,M.W. and C.E.Aston. 2003. A practice approach for identifying previously unsuspected environmental contributors to systemic lupus erythematosus and other complex diseases. Environ.Health Perspect. 111:593-597. [Abstract]
* Gonzalez,M.L., M.B.Frank, P.A.Ramsland, J.S.Hanas, and F.J.Waxman. 2003. Structural analysis of IgG2A monoclonal antibodies in relation to complement deposition and renal immune complex deposition. Molecular Immunology 40:307-317. [Abstract]
Heinlen,L.D., M.T.McClain, X.Kim, D.R.Quintero, J.A.James, J.B.Harley, and R.H.Scofield. 2003. Anti-Ro and anti-nRNP response in unaffected family members of SLE patients. Lupus 12:335-337.
Kaufman,K.M., M.Y.Kirby, J.B.Harley, and J.A.James. 2003. Peptide mimics of a major lupus epitope of SmB/B’. Ann.N.Y.Acad.Sci 987:215-29. {Abstract]
Kurien,B.T. and R.H.Scofield. 2003. Free radical mediated peroxidative damage in systemic lupus erythematosus. Life Sci 73:1655-1666. [Abstract]
Kurien,B.T. and R.H.Scofield. 2003. Protein blotting: a review. J Immunol.Methods 274:1-15.
McClain,M.T., E.C.Rapp, J.B.Harley, and J.A.James. 2003. Infectious mononucleosis patients temporarily recognize a unique, cross-reactive epitope of Epstein-Barr virus nuclear antigen-1. J Med Virol. 70:253-257. [Abstract]
Nakken,B., K.E.Davis, Z.J.Pan, M.Bachmann, and A.D.Farris. 2003. T-helper cell tolerance to ubiquitous nuclear antigens. Scand.J Immunol. 58:478-492. [Abstract]
Namjou,B. 2003. Antiphospholipid syndrome: genetic review. Curr.Rheumatol.Rep. 5:391-394. [Abstract]
Okada,S., E.Weatherhead, I.N.Targoff, R.Wesley, and F.W.Miller. 2003. Global surface ultraviolet radiation intensity may modulate the clinical and immunologic expression of autoimmune muscle disease. Arthritis Rheum. 48:2285-2293. [Abstract]
Reichlin,M. and M.Wolfson-Reichlin. 2003. Correlations of anti-dsDNA and anti-ribosomal P autoantibodies with lupus nephritis. Clin.Immunol. 108:69-72. [Abstract]
Sawalha,A.H., B.D.Lutz, N.A.Chaudhary, W.Kern, J.B.Harley, and R.A.Greenfield. 2003. Panniculitis – A presenting manifestation of disseminated histoplasmosis in a patient with rheumatoid arthritis. JCR-Journal of Clinical Rheumatology 9:259-262.
Sawalha,A.H., R.Potts, W.R.Schmid, R.H.Scofield, and J.B.Harley. 2003. The genetics of primary Sjogren’s syndrome. Curr.Rheumatol.Rep. 5:324-332. [Abstract]
Scofield,R.H., G.R.Bruner, J.A.Kelly, J.Kilpatrick, D.Bacino, S.K.Nath, and J.B.Harley. 2003. Thrombocytopenia identifies a severe familial phenotype of systemic lupus erythematosus and reveals genetic linkages at 1q22 and 11p13. Blood 101:992-997. [Abstract]
Shoham,N.G., M.Centola, E.Mansfield, K.M.Hull, G.Wood, C.A.Wise, and D.L.Kastner. 2003. Pyrin binds the PSTPIP1/CD2BP1 protein, defining familial Mediterranean fever and PAPA syndrome as disorders in the same pathway. Proc.Natl.Acad.Sci.U.S.A 100:13501-13506. [Abstract]
Soares,M.L., M.Centola, J.Chae, M.J.Saraiva, and D.L.Kastner. 2003. Human transthyretin intronic open reading frames are not independently expressed in vivo or part of functional transcripts. Biochim.Biophys.Acta 1626:65-74. [Abstract]
Tucker,A.E., I.I.Salles, D.E.Voth, W.Ortiz-Leduc, H.Wang, I.Dozmorov, M.Centola, and J.D.Ballard. 2003. Decreased glycogen synthase kinase 3-beta levels and related physiological changes in Bacillus anthracis lethal toxin-treated macrophages. Cellular Microbiology 5:523-532. [Abstract]
Visvanathan,S., J.K.Scott, K.K.Hwang, M.Banares, J.M.Grossman, J.T.Merrill, J.FitzGerald, R.U.Chukwuocha, B.P.Tsao, B.H.Hahn, and P.P.Chen. 2003. Identification and characterization of a peptide mimetic that may detect a species of disease-associated anticardiolipin antibodies in patients with the antiphospholipid syndrome. Arthritis Rheum 48:737-745. [Abstract]
Cardiovascular Research Program
Battistini,L., L.Piccio, B.Rossi, S.Bach, S.Galgani, C.Gasperini, L.Ottoboni, D.Ciabini, M.D.Caramia, G.Bernardi, C.Laudanna, E.Scarpini, R.P.McEver, E.C.Butcher, G.Borsellino, and G.Constantin. 2003. CD8+ T cells from acute multiple sclerosis patients display selective increase of adhesiveness in brain venules: a critical role for P-selectin glycoprotein ligand-1. Blood 101:4775-82 [Abstract]
Bridges,L.C., K.R.Hanson, P.H.Tani, T.Mather, and R.D.Bowditch. 2003. Integrin alpha4beta1-Dependent Adhesion to ADAM 28 (MDC-L) Requires an Extended Surface of the Disintegrin Domain. Biochemistry 42:3734-3741. [Abstract]
Carlyon,J.A., M.Akkoyunlu, L.Xia, T.Yago, T.Wang, R.D.Cummings, R.P.McEver, and E.Fikrig. 2003. Murine neutrophils require alpha1,3-fucosylation but not PSGL-1 for productive infection with Anaplasma phagocytophilum. Blood 102:3387-3395. [Abstract]
Chakraborty,R., E.A.Lemke, Z.H.Cao, P.E.Klebba, and D.van der Helm. 2003. Identification and mutational studies of conserved amino acids in the outer membrane receptor protein, FepA, which affect transport but not binding of ferric-enterobactin in Escherichia coli. Biometals 16:507-518. [Abstract]
Collen,A., R.Hanemaaijer, F.Lupu, P.H.Quax, N.Van Lent, J.Grimbergen, E.Peters, P.Koolwijk, and V.W.Van Hinsbergh. 2003. Membrane-type matrix metalloproteinase mediated angiogenesis in a fibrin-collagen matrix. Blood 101: 1810-1817. [Abstract]
Comp,P.C. 2003. Selective factor Xa inhibition improves efficacy of venous thromboembolism prophylaxis in orthopedic surgery. Pharmacotherapy 23:772-787. [Abstract]
Dhainaut,J.F., S.B.Yan, B.D.Margolis, J.A.Lorente, J.A.Russell, R.C.Freebairn, H.D.Spapen, H.Riess, B.Basson, G.Johnson, III, and G.T.Kinasewitz. 2003. Drotrecogin alfa (activated) (recombinant human activated protein C) reduces host coagulopathy response in patients with severe sepsis. Thromb Haemost 90:642-653. [Abstract]
Dias-Baruffi,M., H.Zhu, M.Cho, S.Karmakar, R.P.McEver, and R.D.Cummings. 2003. Dimeric galectin-1 induces surface exposure of phosphatidylserine and phagocytic recognition of leukocytes without inducing apoptosis. J Biol.Chem. 278:41282-41293. [Abstract]
Esmon,C.T. 2003. Coagulation and inflammation. J Endotoxin.Res. 9:192-198. [Abstract]
Esmon,C.T. 2003. Inflammation and thrombosis. J Thromb.Haemost. 1:1343-1348. [Abstract]
Esmon,C.T. 2003. The protein C pathway. Chest 124:26S-32S. [Abstract]
Hrachovinova,I., B.Cambien, A.Hafezi-Moghadam, J.Kappelmayer, R.T.Camphausen, A.Widom, L.J.Xia, H.H.Kazazian, R.G.Schaub, R.P.McEver, and D.D.Wagner. 2003. Interaction of P-selectin and PSGL-1 generates microparticles that correct hemostasis in a mouse model of hemophilia A. Nature Medicine 9:1020-1025. [Abstract]
Huntington,J.A. and C.T.Esmon. 2003. The molecular basis of thrombin allostery revealed by a 1.8 a structure of the “Slow” form. Structure.(Camb.) 11:469-479. [Abstract]
Karmakar,S. and R.Mukherjee. 2003. Integrin receptors and ECM proteins involved in preferential adhesion of colon carcinoma cells to lung cells. Cancer Letters 196:217-227.
Leppanen,A., T.Yago, V.I.Otto, R.P.McEver, and R.D.Cummings. 2003. Model glycosulfopeptides from PSGL-1 require tyrosine sulfation and a core-2 branched O-glycan to bind to L-selectin. J Biol Chem 278:26391-400. [Abstract]
Liaw,P.C.Y., G.Ferrell, and C.T.Esmon. 2003. A monoclonal antibody against activated protein C allows rapid detection of activated protein C in plasma and reveals a calcium ion dependent epitope involved in factor Va inactivation. J Thromb Haemost 1:662-670. [Abstract]
Marshall,B.T., M.Long, J.W.Piper, T.Yago, R.P.McEver, and C.Zhu. 2003. Direct observation of catch bonds involving cell-adhesion molecules. Nature 423:190-193. [Abstract]
Matthay,M.A., G.A.Zimmerman, C.Esmon, J.Bhattacharya, B.Coller, C.M.Doerschuk, J.Floros, M.A.Gimbrone, Jr., E.Hoffman, R.D.Hubmayr, M.Leppert, S.Matalon, R.Munford, P.Parsons, A.S.Slutsky, K.J.Tracey, P.Ward, D.B.Gail, and A.L.Harabin. 2003. Future research directions in acute lung injury: summary of a national heart, lung, and blood institute working group. Am.J Respir.Crit Care Med 167:1027-1035. [Abstract]
Moore,K.L. 2003. The biology and enzymology of protein tyrosine O-sulfation. J.Biol.Chem. 278:24243-24246. [Abstract]
Opal,S.M. and C.T.Esmon. 2003. Bench-to-bedside review: Functional relationships between coagulation and the innate immune response and their respective roles in the pathogenesis of sepsis. Crit Care 7:23-38. [Abstract]
Rossi,M.I., T.Yokota, K.L.Medina, K.P.Garrett, P.C.Comp, A.H.Schipul, Jr., and P.W.Kincade. 2003. B lymphopoiesis is active throughout human life, but there are developmental age-related changes. Blood 101: 576-584. [Abstract]
Setiadi,H. and R.P.McEver. 2003. Signal-dependent distribution of cell surface P-selectin in clathrin-coated pits affects leukocyte rolling under flow. J.Cell Biol. 163:1385-1395. [Abstract]
Siegler,R.L., T.G.Obrig, T.J.Pysher, V.L.Tesh, N.D.Denkers, and F.B.Taylor. 2003. Response to Shiga toxin 1 and 2 in a baboon model of hemolytic uremic syndrome. Pediatr.Nephrol. 18:92-96. [Abstract]
Sperandio,M., M.L.Smith, S.B.Forlow, T.S.Olson, L.Xia, R.P.McEver, and K.Ley. 2003. P-selectin Glycoprotein Ligand-1 Mediates L-Selectin-dependent Leukocyte Rolling in Venules. J Exp.Med 197:1355-1363. [Abstract]
Taylor,F. 2003. Comment on “Drotrecogin Alfa (activated) (recombinant human protein C, rhAPC) reduces host coagulopathy response in patients with severe sepsis”. Thromb.Haemost. 90:560-561.
Xia,L., V.Ramachandran, J.M.McDaniel, K.N.Nguyen, R.D.Cummings, and R.P.McEver. 2003. N-terminal residues in murine P-selectin glycoprotein ligand-1 required for binding to murine P-selectin. Blood 101: 552-9. [Abstract]
Yago,T., A.Leppanen, J.A.Carlyon, M.Akkoyunlu, S.Karmakar, E.Fikrig, R.D.Cummings, and R.P.McEver. 2003. Structurally distinct requirements for binding of P-selectin glycoprotein ligand-1 and sialyl Lewis x to Anaplasma phagocytophilum and P-selectin. J Biol Chem 278:37987-37997. [Abstract]
Clinical Pharmacology Research Program
Bertolaccini,M.L., G.Sanna, S.Ralhan, L.C.Gennari, J.T.Merrill, M.A.Khamashta, and G.R.Hughes. 2003. Antibodies directed to protein S in patients with systemic lupus erythematosus: prevalence and clinical significance. Thromb.Haemost. 90:636-641. [Abstract]
Knopp,R.H., H.Gitter, T.Truitt, H.Bays, C.V.Manion, L.J.Lipka, A.P.LeBeaut, R.Suresh, B.Yang, and E.P.Veltri. 2003. Effects of ezetimibe, a new cholesterol absorption inhibitor, on plasma lipids in patients with primary hypercholesterolemia. Eur.Heart J 24:729-741. [Abstract]
Lopez,D., K.Kobayashi, J.T.Merrill, E.Matsuura, and L.R.Lopez. 2003. IgG autoantibodies against beta2-glycoprotein I complexed with a lipid ligand derived from oxidized low-density lipoprotein are associated with arterial thrombosis in antiphospholipid syndrome. Clin.Dev.Immunol. 10:203-211. [Abstract]
Merrill,J.T. 2003. The antiphospholipid syndrome and atherosclerosis: clue to pathogenesis. Curr.Rheumatol.Rep. 5:401-406. [Abstract]
Merrill,J.T. 2003. Cyclosporin a in antiphospholipid syndrome. Curr.Rheumatol.Rep. 5:382.
Merrill,J.T. 2003. Dehydroepiandrosterone, a sex steroid metabolite in development for systemic lupus erythematosus. Expert.Opin.Investig.Drugs 12:1017-1025. [Abstract]
Merrill,J.T. 2003. Etanercept in antiphospholipid syndrome. Curr.Rheumatol.Rep. 5:381.
Merrill,J.T. 2003. Mycophenolate mofetil in antiphospholipid syndrome. Curr.Rheumatol.Rep. 5:381.
Merrill,J.T. 2003. Rituximab in antiphospholipid syndrome. Curr.Rheumatol.Rep. 5:381-382.
Visvanathan,S., J.K.Scott, K.K.Hwang, M.Banares, J.M.Grossman, J.T.Merrill, J.FitzGerald, R.U.Chukwuocha, B.P.Tsao, B.H.Hahn, and P.P.Chen. 2003. Identification and characterization of a peptide mimetic that may detect a species of disease-associated anticardiolipin antibodies in patients with the antiphospholipid syndrome. Arthritis Rheum. 48:737-745. [Abstract]
Comparative Medicine/LARC
Gruber,H.E., B.Gordon, C.Williams, N.H.James, and E.N.Hanley, Jr. 2003. Bone mineral density of lumbar vertebral end plates in the aging male sand rat spine. Spine 28:1766-1772. [Abstract]
Crystallography Research Program
* Gonzalez,M.L., M.B.Frank, P.A.Ramsland, J.S.Hanas, and F.J.Waxman. 2003. Structural analysis of IgG2A monoclonal antibodies in relation to complement deposition and renal immune complex deposition. Molecular Immunology 40:307-317. [Abstract]
* He,X., G.Zhu, G.Koelsch, K.K.Rodgers, X.C.Zhang, and J.Tang. 2003. Biochemical and Structural Characterization of the Interaction of Memapsin 2 (beta-Secretase) Cytosolic Domain with the VHS Domain of GGA Proteins. Biochemistry 42:12174-12180. [Abstract]
Ramsland,P.A., W.Farrugia, E.Yuriev, A.B.Edmundson, and M.S.Sandrin. 2003. Evidence for structurally conserved recognition of the major carbohydrate xenoantigen by natural antibodies. Cell Mol.Biol (Noisy.-le-grand) 49:307-317. [Abstract]
Terzyan,S.S., C.R.Bourne, P.A.Ramsland, P.C.Bourne, and A.B.Edmundson. 2003. Comparison of the three-dimensional structures of a human Bence-Jones dimer crystallized on Earth and aboard US Space Shuttle Mission STS-95. J Mol.Recognit. 16:83-90. [Abstract]
Wingren,C., A.B.Edmundson, and C.A.Borrebaeck. 2003. Designing proteins to crystallize through beta-strand pairing. Protein Eng 16:255-264. [Abstract]
* Zhai,P., X.He, J.Liu, N.Wakeham, G.Zhu, G.Li, J.Tang, and X.C.Zhang. 2003. The Interaction of the Human GGA1 GAT Domain with Rabaptin-5 Is Mediated by Residues on Its Three-Helix Bundle. Biochemistry 42:13901-13908. [Abstract]
* Zhai,P., N.Wakeham, J.A.Loy, and X.C.Zhang. 2003. Functional roles of streptokinase C-terminal flexible Peptide in active site formation and substrate recognition in plasminogen activation. Biochemistry 42:114-120. [Abstract]
* Zhu,G., X.He, P.Zhai, S.Terzyan, J.Tang, and X.C.Zhang. 2003. Crystal structure of GGA2 VHS domain and its implication in plasticity in the ligand binding pocket. FEBS Lett 537:171-176. [Abstract]
Zhu,G., J.Liu, S.Terzyan, P.Zhai, G.Li, and X.C.Zhang. 2003. High resolution crystal structures of human Rab5a and five mutants with substitutions in the catalytically important phosphate-binding loop. J Biol Chem 278:2452-60. [Abstract]
* Zhu,G., P.Zhai, X.He, S.Terzyan, R.Zhang, A.Joachimiak, J.Tang, and X.C.Zhang. 2003. Crystal Structure of the Human GGA1 GAT Domain. Biochemistry 42:6392-6399. [Abstract]
Developmental Biology Research Program
Brennan,M.B., J.L.Costa, S.Forbes, P.Reed, S.Bui, and U.Hochgeschwender. 2003. Alpha-melanocyte-stimulating hormone is a peripheral, integrative regulator of glucose and fat metabolism. Ann.N.Y.Acad.Sci 994:282-7. [Abstract]
Hochgeschwender,U., J.L.Costa, P.Reed, S.Bui, and M.B.Brennan. 2003. Altered glucose homeostasis in proopiomelanocortin-null mouse mutants lacking central and peripheral melanocortin. Endocrinology 144:5194-5202. [Abstract]
Le,Y., S.Gagneten, T.Larson, E.Santha, A.Dobi, D.Agoston, and B.Sauer. 2003. Far-upstream elements are dispensable for tissue-specific proenkephalin expression using a Cre-mediated knock-in strategy. J Neurochem. 84:689-697. [Abstract]
O’Shaughnessy,P.J., L.M.Fleming, G.Jackson, U.Hochgeschwender, P.Reed, and P.J.Baker. 2003. Adrenocorticotropic hormone directly stimulates testosterone production by the fetal and neonatal mouse testis. Endocrinology 144:3279-3284. [Abstract]
Videau,C., U.Hochgeschwender, H.J.Kreienkamp, M.B.Brennan, C.Viollet, D.Richter, and J.Epelbaum. 2003. Characterisation of [(125)I]-Tyr(o)DTrp(8)-somatostatin binding in sst1- to sst4- and SRIF-gene-invalidated mouse brain. Naunyn Schmiedebergs Arch Pharmacol 367:562-71. [Abstract]
Free Radical Biology and Aging Program
Hamdheydari,L., A.Christov, T.Ottman, K.Hensley, and P.Grammas. 2003. Oxidized LDLs affect nitric oxide and radical generation in brain endothelial cells. Biochem.Biophys.Res.Commun. 311:486-490. [Abstract]
Hensley,K., J.Fedynyshyn, S.Ferrell, R.A.Floyd, B.Gordon, P.Grammas, L.Hamdheydari, M.Mhatre, S.Mou, Q.N.Pye, C.Stewart, M.West, S.West, and K.S.Williamson. 2003. Message and protein-level elevation of tumor necrosis factor alpha (TNFalpha) and TNFalpha-modulating cytokines in spinal cords of the G93A-SOD1 mouse model for amyotrophic lateral sclerosis. Neurobiol.Dis. 14:74-80. [Abstract]
Kaneko,T., D.J.Stearns-Kurosawa, J.F.Taylor, M.Twigg, K.Osaki, G.T.Kinasewitz, G.Peer, and S.Kurosawa. 2003. Reduced Neutrophil CD10 Expression in Nonhuman Primates and Humans After In Vivo Challenge with E. coli or Lipopolysaccharide. Shock 20:130-137. [Abstract]
Kotake,Y., D.R.Moore, A.Vasquez-Walden, T.Tabatabaie, and H.Sang. 2003. Antioxidant amplifies antibiotic protection in the cecal ligation and puncture model of microbial sepsis through interleukin-10 production. Shock 19:252-256. [Abstract]
Mhatre,M. and F.Holloway. 2003. Micro1-opioid antagonist naloxonazine alters ethanol discrimination and consumption. Alcohol 29:109-116. [Abstract]
Nakae,D., H.Kishida, T.Enami, Y.Konishi, K.L.Hensley, R.A.Floyd, and Y.Kotake. 2003. Effects of phenyl N-tert-butyl nitrone and its derivatives on the early phase of hepatocarcinogenesis in rats fed a choline-deficient, L-amino acid-defined diet. Cancer Sci 94:26-31. [Abstract]
Ranchon,I., M.M.LaVail, Y.Kotake, and R.E.Anderson. 2003. Free radical trap phenyl-N-tert-butylnitrone protects against light damage but does not rescue P23H and S334ter rhodopsin transgenic rats from inherited retinal degeneration. J Neurosci. 23:6050-6057. [Abstract]
Stearns-Kurosawa,D.J., C.Burgin, D.Parker, P.Comp, and S.Kurosawa. 2003. Bimodal distribution of soluble endothelial protein C receptor levels in healthy populations. J Thromb.Haemost. 1:855-856.
Tabatabaie,T., A.Vasquez-Weldon, D.R.Moore, and Y.Kotake. 2003. Free Radicals and the Pathogenesis of Type 1 Diabetes: beta-Cell Cytokine-Mediated Free Radical Generation Via Cyclooxygenase-2. Diabetes 52:1994-1999. [Abstract]
Thom,S.R., D.Fisher, J.Zhang, V.M.Bhopale, S.T.Ohnishi, Y.Kotake, T.Ohnishi, and D.G.Buerk. 2003. Stimulation of perivascular nitric oxide synthesis by oxygen. Am J Physiol Heart Circ Physiol 284:H1230-9. [Abstract]
Towner,R.A., S.Y.Qian, M.B.Kadiiska, and R.P.Mason. 2003. In vivo identification of aflatoxin-induced free radicals in rat bile. Free Radic.Biol.Med. 35:1330-1340. [Abstract]
Wrona,M.Z., X.R.Jiang, Y.Kotake, and G.Dryhurst. 2003. Stability of the Putative Neurotoxin Tryptamine-4,5-dione. Chem Res.Toxicol. 16:493-501. [Abstract]
Immunobiology Research Program
Fanzo,J.C., M.P.Lynch, H.Phee, M.Hyer, A.Cremesti, H.Grassme, J.S.Norris, K.M.Coggeshall, B.R.Rueda, A.B.Pernis, R.Kolesnick, and E.Gulbins. 2003. CD95 Rapidly Clusters in Cells of Diverse Origins. Cancer Biol.Ther. 2:392-395. [Abstract]
Garrison,H.H., S.A.Gerbi, and P.W.Kincade. 2003. In an Era of Scientific Opportunity, Are There Opportunities for Biomedical Scientists? FASEB J. 17: 2169-73. [Abstract]
Hashikawa,T., M.Takedachi, M.Terakura, T.Saho, S.Yamada, L.F.Thompson, Y.Shimabukuro, and S.Murakami. 2003. Involvement of CD73 (ecto-5′-nucleotidase) in Adenosine Generation by Human Gingival Fibroblasts. J Dent.Res. 82:888-892. [Abstract]
Katoh,S., N.Matsumoto, K.Kawakita, A.Tominaga, P.W.Kincade, and S.Matsukura. 2003. A role for CD44 in an antigen-induced murine model of pulmonary eosinophilia. J Clin.Invest 111:1563-1570. [Abstract]
Kincade,P.W. 2003. The importance of environment in the production of lymphocytes and immunologists. J Immunol. 171:4953-4956. [Abstract]
Kincade,P.W. and G.Kelsoe. 2003. A birthday for B cells: Lymphopoiesis II, a scientific symposium honoring Max Cooper. Nat.Immunol. 4:1155-1157. Corrigendum 5: 554.
Manjeshwar,S., D.E.Branam, M.R.Lerner, D.J.Brackett, and E.R.Jupe. 2003. Tumor suppression by the prohibitin gene 3’untranslated region RNA in human breast cancer. Cancer Res. 63:5251-5256. [Abstract]
Nie,L., M.Xu, A.Vladimirova, and X.H.Sun. 2003. Notch-induced E2A ubiquitination and degradation are controlled by MAP kinase activities. EMBO J 22:5780-5792. [Abstract]
Oritani,K., S.Hirota, T.Nakagawa, I.Takahashi, S.Kawamoto, M.Yamada, N.Ishida, T.Kadoya, Y.Tomiyama, P.W.Kincade, and Y.Matsuzawa. 2003. T lymphocytes constitutively produce an interferonlike cytokine limitin characterized as a heat- and acid-stable and heparin-binding glycoprotein. Blood 101:178-185. [Abstract]
*Rossi,M.I., T.Yokota, K.L.Medina, K.P.Garrett, P.C.Comp, A.H.Schipul, Jr., and P.W.Kincade. 2003. B lymphopoiesis is active throughout human life, but there are developmental age-related changes. Blood 101: 576-584. [Abstract]
Thompson,L.F., J.G.Vaughn, A.B.Laurent, M.R.Blackburn, and C.J.Van De Wiele. 2003. Mechanisms of apoptosis in developing thymocytes as revealed by adenosine deaminase-deficient fetal thymic organ cultures. Biochem.Pharmacol. 66:1595-1599. [Abstract]
Xu,M., L.Nie, S.H.Kim, and X.H.Sun. 2003. STAT5-induced Id-1 transcription involves recruitment of HDAC1 and deacetylation of C/EBPbeta. EMBO J 22:893-904. [Abstract]
Yokota,T., T.Kouro, J.Hirose, H.Igarashi, K.P.Garrett, S.C.Gregory, N.Sakaguchi, J.J.Owen, and P.W.Kincade. 2003. Unique properties of fetal lymphoid progenitors identified according to RAG1 gene expression. Immunity. 19:365-375. [Abstract]
Yokota,T., C.S.Meka, T.Kouro, K.L.Medina, H.Igarashi, M.Takahashi, K.Oritani, T.Funahashi, Y.Tomiyama, Y.Matsuzawa, and P.W.Kincade. 2003. Adiponectin, a fat cell product, influences the earliest lymphocyte precursors in bone marrow cultures by activation of the cyclooxygenase-prostaglandin pathway in stromal cells. J Immunol. 171:5091-5099. [Abstract]
Lipid and Lipoprotein Laboratory
Alaupovic,P. 2003. The Concept of Apolipoprotein-defined Lipoprotein Families and Its Clinical Significance. Curr.Atheroscler.Rep. 5:459-467. [Abstract]
Attman,P.O., O.Samuelsson, A.C.Johansson, J.B.Moberly, and P.Alaupovic. 2003. Dialysis modalities and dyslipidemia. Kidney Int Suppl 110-112. [Abstract]
Blackett,P.R., R.Germany, B.Sambo, and P.Alaupovic. 2003. Apolipoprotein C-III Bound to Apolipoprotein B-containing Lipoproteins in Obese Girls. Clin.Chem 49:303-306.
Lindholm,L.H., M.Persson, P.Alaupovic, B.Carlberg, A.Svensson, and O.Samuelsson. 2003. Metabolic outcome during 1 year in newly detected hypertensives: results of the Antihypertensive Treatment and Lipid Profile in a North of Sweden Efficacy Evaluation (ALPINE study). J Hypertens. 21:1563-1574. [Abstract]
Molecular and Cellular Biology Research Program
Grisoni,K., K.Gieseler, M.C.Mariol, E.Martin, M.Carre-Pierrat, G.Moulder, R.Barstead, and L.Segalat. 2003. The stn-1 Syntrophin Gene of C.elegans is Functionally Related to Dystrophin and Dystrobrevin. J Mol.Biol. 332:1037-1046. [Abstract]
Hochgeschwender,U., J.L.Costa, P.Reed, S.Bui, and M.B.Brennan. 2003. Altered Glucose Homeostasis in POMC Null Mouse Mutants Lacking Central and Peripheral Melanocortin. Endocrinology. 144:5194-5202 [Abstract]
Kaletta,T., C.M.Van Der, A.Van Geel, N.Dewulf, T.Bogaert, M.Branden, K.V.King, M.Buechner, R.Barstead, D.Hyink, H.P.Li, L.Geng,
C.Burrow, and P.Wilson. 2003. Towards understanding the polycystins. Nephron 93:E9-E17. [Abstract]
Loria,P.M., A.Duke, J.B.Rand, and O.Hobert. 2003. Two neuronal, nuclear-localized RNA binding proteins involved in synaptic transmission. Curr.Biol. 13:1317-1323. [Abstract]
Molecular Immunology Research Program
Capra,J.D. 2003. Some reflections on being a postdoc with Henry Kunkel. Lupus 12:157.
Gilmore,K.S., P.Srinivas, D.R.Akins, K.L.Hatter, and M.S.Gilmore. 2003. Growth, Development, and Gene Expression in a Persistent Streptococcus gordonii Biofilm. Infect.Immun. 71:4759-4766. [Abstract]
Jordan,S. and W.Rodgers. 2003. T cell glycolipid-enriched membrane domains are constitutively assembled as membrane patches that translocate to immune synapses. J Immunol. 171:78-87. [Abstract]
Kolar,G.R. and J.D.Capra. 2003. The NOD/SCID chimeric mouse model of human B cell development: studies on the VH4 family immunoglobulin repertoire and implications for SLE. Lupus 12:158-162. [Abstract]
Lee,S.J., N.Y.Zheng, M.Clavijo, and M.C.Nussenzweig. 2003. Normal Host Defense during Systemic Candidiasis in Mannose Receptor-Deficient Mice. Infect.Immun. 71:437-445. [Abstract]
Steiner,L.A., K.L.Knight, and J.D.Capra. 2003. Alfred Nisonoff. Biogr.Mem.Natl.Acad.Sci. 83:160-175.
Protein Studies Research Program
* He,X., G.Zhu, G.Koelsch, K.K.Rodgers, X.C.Zhang, and J.Tang. 2003. Biochemical and Structural Characterization of the Interaction of Memapsin 2 (beta-Secretase) Cytosolic Domain with the VHS Domain of GGA Proteins. Biochemistry 42:12174-12180. [Abstract]
Koelsch,G., R.T.Turner, III, L.Hong, A.K.Ghosh, and J.Tang. 2003. Memapsin 2, a drug target for Alzheimer’s disease. Biochem.Soc.Symp.213-220. [Abstract]
Tang,J., A.K.Ghosh, L.Hong, G.Koelsch, R.T.Turner, and W.Chang. 2003. Study of Memapsin 2 (beta-Secretase) and Strategy of Inhibitor Design. J Mol.Neurosci. 20:299-304 [Abstract]
* Zhai,P., X.He, J.Liu, N.Wakeham, G.Zhu, G.Li, J.Tang, and X.C.Zhang. 2003. The Interaction of the Human GGA1 GAT Domain with Rabaptin-5 Is Mediated by Residues on Its Three-Helix Bundle. Biochemistry 42:13901-13908. [Abstract]
* Zhai,P., N.Wakeham, J.A.Loy, and X.C.Zhang. 2003. Functional roles of streptokinase C-terminal flexible Peptide in active site formation and substrate recognition in plasminogen activation. Biochemistry 42:114-120. [Abstract]
* Zhu,G., X.He, P.Zhai, S.Terzyan, J.Tang, and X.C.Zhang. 2003. Crystal structure of GGA2 VHS domain and its implication in plasticity in the ligand binding pocket. FEBS Lett 537:171-176. [Abstract]
* Zhu,G., P.Zhai, X.He, S.Terzyan, R.Zhang, A.Joachimiak, J.Tang, and X.C.Zhang. 2003. Crystal Structure of the Human GGA1 GAT Domain. Biochemistry 42:6392-6399. [Abstract]
* Indicates publications by more than one department.
01/13/10