What We Do
The Cardiovascular Biology Research Program investigates fundamental mechanisms involved in blood and lymphatic vessel function, atherogenesis, blood coagulation, inflammation, and sepsis.
This program utilizes a multidisciplinary approach to address these questions at a molecular level. This approach encompasses structural biology, structure-function analysis of enzymes and receptors, regulation of the relevant genes, in vivo studies using transgenic and gene deletion approaches, cell biology, protein chemistry, physiological studies, and biophysical methods for analyzing protein-protein, membrane-protein, and cell-cell interactions.
The multidisciplinary approach provides insights into processes with relevance to many human diseases, including heart attack, stroke, septic shock, cancer, and inflammatory bowel disease. Several findings by program members have generated patents and licenses that may lead to new diagnostics and therapeutics.
Member and Program Chair
Ahamed J, Laurence J. Role of platelet-derived TGF-β1 and ROS in radiation-induced organ fibrosis. Antioxid Redox Signal. 2017 May 31. Epub ahead of print. PMID: 28562065
*Barboza E, Hudson J, Chang WP, Kovats S, Towner RA, Silasi-Mansat R, Lupu F, Kent C, Griffin TM. Pro-fibrotic infrapatellar fat pad remodeling without M1-macrophage polarization precedes knee osteoarthritis in diet-induced obese mice. Arthritis Rheumatol. 2017 Jun;69(6):1221-1232. PMID: 28141918
Chandrakesan P, Yao J, Qu D, May R, Weygant N, Ge Y, Ali N, Sureban SM, Gude M, Vega K, Bannerman-Menson E, Xia L, Bronze M, An G, Houchen CW. Dclk1, a tumor stem cell marker, regulates pro-survival signaling and self-renewal of intestinal tumor cells. Mol Cancer. 2017 Feb 1;16(1):30. PMCID:PMC5286867
Chen C, Yang L, Villoutreix BO, Wang X, Ding Q, Rezaie AR. Gly74Ser mutation in protein C causes thrombosis due to a defect in protein S-dependent anticoagulant function. Thromb Haemost. 2017 Apr 13. Epub ahead of print. PMID: 28405673
Fuentes-Mattei E, Giza DE, Shimizu M, Ivan C, Manning JT, Tudor S, Ciccone M, Kargin OA, Zhang X, Mur P, do Amaral NS, Chen M, Tarrand JJ, Lupu F, Ferrajoli A, Keating MJ, Vasilescu C, Yeung SJ, Calin GA. Plasma Viral miRNAs Indicate a High Prevalence of Occult Viral Infections. EBioMedicine. 2017 Apr 19. S2352-3964(17) 30162-7. Epub ahead of print. PMID: 28465156
Healy LD, Puy C, Fernández JA, Mitrugno A, Keshari RS, Taku NA, Chu TT, Xu X, Gruber A, Lupu F, Griffin JH, McCarty OJ. Activated protein C inhibits neutrophil extracellular trap formation in vitro and activation in vivo. J Biol Chem. 2017 May 26;292(21):8616-29. PMCID: PMC5448091
Liu Z, Yago T, Zhang N, Panicker SR, Wang Y, Yao L, Mehta-D'souza P, Xia L, Zhu C, McEver RP. L-selectin mechanochemistry restricts neutrophil priming in vivo. Nat Commun. 2017 May 12;8:15196. PMCID: PMC5437312
Mehta-D'souza P, Klopocki AG, Oganesyan V, Terzyan S, Mather T, Li Z, Panicker SR, Zhu C, McEver RP. Glycan Bound to the Selectin Low Affinity State Engages Glu-88 to Stabilize the High Affinity State under Force. J Biol Chem. 2017 Feb 10;292(6):2510-18. PMCID: PMC5313117
Sun C, Berry WL, Olson LE. PDGFRα controls the balance of stromal and adipogenic cells during adipose tissue organogenesis. Development. 2017 Jan 1;144(1):83-94. PMCID: PMC5278626
Yan B, Xu M, Zhao Y, Guo H, Xia L, Ruan C, Zhao Y. Development of a novel flow cytometric immunobead array to quantify VWF:Ag and VWF:GPIbR and its application in acute myocardial infarction. Eur J Haematol. 2017 May 18. Epub ahead of print. PMID: 28523822
* Publications with other research Programs
Cardiovascular Biology Research Program
Oklahoma Medical Research Foundation
825 NE 13th Street, MS 45
Oklahoma City, OK 73104
Phone: (405) 271-6480
Fax: (405) 271-3137