Aging & Metabolism Research Program

Metabolism produces the building blocks and energy necessary for life through an elegant series of dynamically regulated biochemical transformations. Defects in metabolism arise as we age. Scientists in the Aging & Metabolism Research Program have a common interest in the metabolic basis of age-related disease and in extending the health of our aging population.

Our investigators study a variety of age-related diseases integrated across multiple organ systems, including heart failure, diabetic cardiomyopathy, macular degeneration, osteoarthritis, sarcopenia, and neurodegenerative disorders. Common among these afflictions are alterations in cellular metabolism and energy production. Mitochondria are intracellular organelles that play an essential role in metabolism and in the response of cells to physiologic and pathophysiologic stress.

The laboratories that comprise our Program investigate distinct aspects of mitochondrial and cellular metabolism, identifying alterations that occur with age that are exacerbated by obesity and diabetes. Associated defects in energy homeostasis, cellular and mitochondrial quality control, production and removal of toxic free radical species, and the inflammatory response are explored to define underlying causes of diseases that primarily afflict the elderly. Together, these multidisciplinary approaches create a synergistic, collaborative, and creative environment that fosters discovery and training.

2025

Mesquita PHC, Halle JL, Fuqua JD, Miller BF. Applying lessons from limb muscle disuse and ageing to better understand ventilator-induced diaphragm dysfunction. Exp Physiol, 2025 July, PMID: 40638619

Converse A, Perry MJ, Dipali SS, Isola JVV, Kelly EB, Varberg JM, Zelinski MB, Stout MB, Pritchard MT, Duncan FE. Multinucleated giant cells are hallmarks of ovarian aging with unique immune and degradation-associated molecular signatures. PLoS Biol 23:e3003204, 2025 June, PMID: 40550000, PMCID: PMC12185119

Sok SPM, Cheng J, Strucinska K, Popescu NI, Wu L, Ke Q, Kiosses WB, Stanford D, Freeman WM, Matsuzaki S, Lewis TL Jr, Zhao M. P-glycoprotein expression skews mitochondrial dye measurements in T cells. Front Immunol 16:1560104, 2025 June, PMID: 40607427, PMCID: PMC12213397

Szulta A, Wang L, Hasan A, Kinter M, Pranay A, Zhu J, Humphries KM, Loveland B, Griffin TM, Bieniasz M. The Identification of a Key Regulator of Mitochondrial Metabolism, the LRPPRC Protein, as a Novel Therapeutic Target in SDHA-Overexpressing Ovarian Tumors. Cancers (Basel) 17, 2025 June, PMID: 40563592, PMCID: PMC12190274

Das S, Varshney RR, Farriester JW, Kyere-Davies G, Martinez AE, Hill KB, Kinter M, Mullen GP, Nagareddy PR, Rudolph MC. Activating nuclear receptor subfamily 2 group F member 2 in adipocyte stem cells rescues beige adipocyte metabolism impaired by excess early-life omega-6 fatty acids. Clin Nutr 51:63-80, 2025 June, PMID: 40527120, PMCID: PMC12257918

Eeda V, Hedrick AF, Pranay A, Humphries KM, Heidenreich E, Awasthi V. Cardiotropic ligand-guided liposomes for myocardial delivery of atorvastatin in a mouse model of myocardial infarction. Int J Pharm 681:125841, 2025 June, PMID: 40499599

Graham ZA, Bubak MP, Raymond-Pope CJ, Cutter GR, McAdam JS, Tuggle SC, Siedlik JA, de Sousa LGO, Chappe EJ, Meece K, Kaur A, Ruiz BSR, Bamman SC, Vanselow KM, Perry TW, Acosta-Arreguin JS, Bohmke NJ, Addison GJ, Bowers JM, Wright RL, Fuentes LD, Smith JE, Esser KA, Miller BF, Bodine SC, Bamman MM. Multidimensional Modeling to Maximize Adaptations to eXercise: The M(3)AX Trial Rationale and Study Design. medRxiv, 2025 May, PMID: 40492097, PMCID: PMC12148272

Harold KM, Matsuzaki S, Pranay A, Zhu J, Faakye A, Humphries KM. PFKFB2 is Pivotal for Metabolic Flexibility and Differential Glucose Utilization. bioRxiv, 2025 May, PMID: 40502119, PMCID: PMC12154713

Eyster C, Matsuzaki S, Pranay A, Giorgione JR, Faakye A, Ahmed M, Humphries KM. Mechanistic studies of PFKFB2 reveal a novel inhibitor of its kinase activity. PLoS One 20:e0317167, 2025 May, PMID: 40402947, PMCID: PMC12097583

Bodine SC, Goodman CA. Mechanically sensitive MAPK signalling mediates resistance exercise-induced muscle growth. Nat Metab, 2025 May, PMID: 40374924

Nguyen NGT, Sapkota H, Shibata Y, Fesiuk A, Antalek M, Sail V, Ansel DJ, Amici DR, Peelor FF, Van Remmen H, Miller BF, Mendillo ML, Morimoto RI, Li J. HSF1 remodels mitochondrial biogenesis and function in cancer cells via TIMM17A. bioRxiv, 2025 May, PMID: 40463013, PMCID: PMC12132197

Drumond-Bock AL, Blankenship HE, Pham KD, Carter KA, Freeman WM, Beckstead MJ. Parallel gene expression changes in ventral midbrain dopamine and GABA neurons during normal aging. eNeuro, 2025 May, PMID: 40360281, PMCID: PMC12121937

O'Reilly CL, Davidyan A, Cizio K, Doidge SM, Bubak MP, Borowik AK, Lewis TL Jr, Miller BF. Combining In Vivo 2-Photon Imaging with Photoactivatable Fluorescent Labeling Shows Low Rates of Mitochondrial Dynamics in Skeletal Muscle. Med Sci Sports Exerc, 2025 May, PMID: 40310022

Faakye A, Harold KM, Matsuzaki S, Pranay A, Mendez Garcia MF, Loveland BL, Rigsby SN, Peelor FF 3rd, Eyster C, Miller BF, Griffin TM, Kinter M, Chiao YA, Humphries KM. The effect of enhanced glycolysis on cardiac aging. Geroscience, 2025 May, PMID: 40310487

Wood TWP, Henriques WS, Cullen HB, Romero M, Blengini CS, Sarathy S, Sorkin J, Bekele H, Jin C, Kim S, Wang X, Laureau R, Chemiakine A, Khondker RC, Isola JVV, Stout MB, Gennarino VA, Mogessie B, Jain D, Schindler K, Suh Y, Wiedenheft B, Berchowitz LE. The retrotransposon-derived capsid genes PNMA1 and PNMA4 maintain reproductive capacity. Nat Aging, 2025 April, PMID: 40263616, PMCID: PMC12180178

Sharpe AL, Liter LR, Donohue D, Carter KA, Vangeneugden P, Weaver SM, Stout MB, Beckstead MJ. Aged mice exhibit faster acquisition of intravenous opioid self-administration with variable effects on intake. Neuropharmacology:110464, 2025 April, PMID: 40228626, PMCID: PMC12065658

Kobak KA, Zarzycka W, King CJ, Borowik AK, Peelor FF 3rd, Baehr LM, Leutert M, Rodriguez-Mias RA, Villén J, Bodine SC, Kinter MT, Miller BF, Chiao YA. Proteostatic Imbalance Drives the Pathogenesis and Age-Related Exacerbation of Heart Failure With Preserved Ejection Fraction. JACC Basic Transl Sci 10:475-497, 2025 April, PMID: 40306856, PMCID: PMC12134603

Wu C, Chen D, Stout MB, Wu M, Wang S. Hallmarks of ovarian aging. Trends Endocrinol Metab, 2025 February, PMID: 40000274

Drumond-Bock AL, Beckstead MJ. Ketones on the Brain: Can Diet Help Turn the Tables on Parkinson's?-Commentary on Mahajan et al. (2024). Eur J Neurosci 61:e70025, 2025 February, PMID: 39937087

Sklivas AB, Hettinger ZR, Rose S, Mantuano A, Confides AL, Rigsby S, Peelor FF 3rd, Miller BF, Butterfield TA, Dupont-Versteegden EE. Responses of skeletal muscle to mechanical stimuli in female rats following and during muscle disuse atrophy. J Appl Physiol (1985), 2025 January, PMID: 39884317, PMCID: PMC12184423

Tang W, Wang K, Feng Y, Tsui KH, Singh KK, Stout MB, Wang S, Wu M. Exploration of the mechanism and therapy of ovarian aging by targeting cellular senescence. Life Med 4:lnaf004, 2025 January, PMID: 40110109, PMCID: PMC11916902

Laumonnerie C, Shamambo M, Stabley DR, Lewis TL Jr, Trivedi N, Howell D, Solecki DJ. Siah2 antagonism of Pard3/JamC modulates Ntn1-Dcc signaling to regulate cerebellar granule neuron germinal zone exit. Nat Commun 16:355, 2025 January, PMID: 39774925, PMCID: PMC11706986

Strucinska K, Kneis P, Pennington T, Cizio K, Szybowska P, Morgan A, Weertman J, Lewis TL Jr. Fis1 is required for the development of the dendritic mitochondrial network in pyramidal cortical neurons. bioRxiv, 2025 January, PMID: 39829888, PMCID: PMC11741399

Plafker KS, Georgescu C, Pezant N, Pranay A, Plafker SM. Sulforaphane acutely activates multiple starvation response pathways. Front Nutr 11:1485466, 2025 January, PMID: 39867556, PMCID: PMC11758633

2024

Borowik AK, Murach KA, Miller BF. The expanding roles of myonuclei in adult skeletal muscle health and function. Biochem Soc Trans 52:1-14, 2024 December, PMID: 39700019

Isola JVV, Biswas S, Jayarathne H, Hubbart CR, Hense JD, Matsuzaki S, Kinter MT, Humphries KM, Ocañas SR, Sadagurski M, Stout MB. Canagliflozin treatment prevents follicular exhaustion and attenuates hallmarks of ovarian aging in genetically heterogenous mice. Geroscience, 2024 December, PMID: 39672978, PMCID: PMC12181533

Griffin TM, Lopes EBP, Cortassa D, Batushansky A, Jeffries MA, Makosa D, Jopkiewicz A, Mehta-D'souza P, Komaravolu RK, Kinter MT. Sexually dimorphic metabolic effects of a high fat diet on knee osteoarthritis in mice. Biol Sex Differ 15:103, 2024 December, PMID: 39639386, PMCID: PMC11619521

Corder KM, Hoffman JM, Sogorovic A, Yang Y, Banerjee A, Sun Y, Stout MB, Austad SN. Negative effects of lifespan extending intervention on resilience in mice. PLoS One 19:e0312440, 2024 November, PMID: 39570905, PMCID: PMC11581327

Ortlund E, Hou Z, Chen CY, Gaul D, Zhang T, Moore S, Liu X, Ivanova A, Maner-Smith K, Newgard C, Bodine S, Savage E, Bennett A, Fernandez F. Endurance Exercise Training Alters Lipidomic Profiles of Plasma and Eight Tissues in Rats: a MoTrPAC study. Res Sq, 2024 November, PMID: 39606465, PMCID: PMC11601870

Blankenship HE, Carter KA, Pham KD, Cassidy NT, Markiewicz AN, Thellmann MI, Sharpe AL, Freeman WM, Beckstead MJ. VTA dopamine neurons are hyperexcitable in 3xTg-AD mice due to casein kinase 2-dependent SK channel dysfunction. Nat Commun 15:9673, 2024 November, PMID: 39516200, PMCID: PMC11549218

Nguyen HVM, Ran Q, Salmon AB, Ahn B, Chiao YA, Bhaskaran S, Richardson A. Mouse Models Used to Test the Role of Reactive Oxygen Species in Aging and Age-Related Chronic Diseases. Free Radic Biol Med, 2024 October, PMID: 39419456, PMCID: PMC11624111

Zarzycka W, Kobak KA, King CJ, Peelor FF 3rd, Miller BF, Chiao YA. Hyperactive mTORC1/4EBP1 signaling dysregulates proteostasis and accelerates cardiac aging. Geroscience, 2024 October, PMID: 39379739, PMCID: PMC11979070

Ramirez-Sagredo A, Sunny AT, Cupp-Sutton KA, Chowdhury T, Zhao Z, Wu S, Chiao YA. Characterizing age-related changes in intact mitochondrial proteoforms in murine hearts using quantitative top-down proteomics. Clin Proteomics 21:57, 2024 September, PMID: 39343872, PMCID: PMC11440756

Laumonnerie C, Shamambo M, Stabley DR, Lewis TL Jr, Trivedi N, Howell D, Solecki DJ. Antagonistic action of Siah2 and Pard3/JamC to promote germinal zone exit of differentiated cerebellar granule neurons by modulating Ntn1 signaling via Dcc. Res Sq, 2024 September, PMID: 39399669, PMCID: PMC11469462

Musci RV, Fuqua JD, Peelor FF 3rd, Nguyen HVM, Richardson A, Choi S, Miller BF, Wanagat J. Age-induced changes in skeletal muscle mitochondrial DNA synthesis, quantity, and quality in genetically unique rats. Geroscience, 2024 September, PMID: 39312152, PMCID: PMC11872842

Das S, Varshney R, Farriester JW, Kyere-Davies G, Martinez AE, Hill K, Kinter M, Mullen GP, Nagareddy PR, Rudolph MC. NR2F2 Reactivation in Early-life Adipocyte Stem-like Cells Rescues Adipocyte Mitochondrial Oxidation. bioRxiv, 2024 September, PMID: 39314382, PMCID: PMC11419096

Sharpe AL, Liter LR, Donohue D, Carter KA, Vangeneugden P, Weaver S, Stout MB, Beckstead MJ. Aged mice exhibit faster acquisition of intravenous opioid self-administration with variable effects on intake. bioRxiv, 2024 September, PMID: 39282417, PMCID: PMC11398421

Kemna RE, Kueck PJ, Blankenship A, John CS, Johnson CN, Green ZD, Chamberlain T, Thyfault JP, Mahnken JD, Miller BF, Morris JK. Methods to characterize lactate turnover in aging and Alzheimer's disease; The LEAN study. Contemp Clin Trials:107682, 2024 September, PMID: 39236780, PMCID: PMC11938302

Kim H, Ranjit R, Claflin DR, Georgescu C, Wren JD, Brooks SV, Miller BF, Ahn B. Unacylated Ghrelin Protects Against Age-Related Loss of Muscle Mass and Contractile Dysfunction in Skeletal Muscle. Aging Cell:e14323, 2024 September, PMID: 39223708, PMCID: PMC11634730

Nasuhidehnavi A, Zarzycka W, Górecki I, Chiao YA, Lee CF. Emerging interactions between mitochondria and NAD( ) metabolism in cardiometabolic diseases. Trends Endocrinol Metab, 2024 August, PMID: 39198117, PMCID: PMC11794032

Sok SPM, Pipkin K, Popescu NI, Reidy M, Li B, Van Remmen H, Kinter M, Sun XH, Fan Z, Zhao M. Gpx4 Regulates Invariant NKT Cell Homeostasis and Function by Preventing Lipid Peroxidation and Ferroptosis. J Immunol, 2024 August, PMID: 39158281, PMCID: PMC11408103

Sathiaseelan R, Isola JVV, Santín-Márquez R, Adekunbi D, Fornalik M, Salmon AB, Stout MB. A pilot study evaluating dosing tolerability of 17α-estradiol in male common marmosets (Callithrix jacchus). Geroscience, 2024 August, PMID: 39107620, PMCID: PMC11872862

Iannitelli AF, Hassenein L, Mulvey B, Blankenship HE, Liles LC, Sharpe AL, Pare JF, Segal A, Sloan SA, Martinowich K, McCann KE, Dougherty JD, Smith Y, Beckstead MJ, Weinshenker D. Tyrosinase-induced neuromelanin accumulation triggers rapid dysregulation and degeneration of the mouse locus coeruleus. bioRxiv, 2024 August, PMID: 36945637, PMCID: PMC10028911

Tandon I, Woessner A, Ferreira LA, Shamblin C, Vaca-Diez G, Walls A, Kuczwara P, Applequist A, Nascimento DF, Tandon S, Kim JW, Rausch M, Timek T, Padala M, Kinter MT, Province D, Byrum SD, Quinn KP, Balachandran K. A Three-Dimensional Valve-on-Chip Microphysiological System Implicates Cell Cycle Progression, Cholesterol Metabolism and Protein Homeostasis in Early Calcific Aortic Valve Disease Progression. Acta Biomater, 2024 July, PMID: 39084496, PMCID: PMC11702842

Hense JD, Garcia DN, Zanini BM, Barreto MM, Perreira GC, Isola JVV, de Brito C, Fornalik M, Mondal SA, Ávila BM, Oliveira TL, Rice HC, Lacy CI, Vaucher RA, Mason JB, Masternak MM, Stout MB, Schneider A. MASLD does not affect fertility and senolytics fail to prevent MASLD progression in male mice. Sci Rep 14:17332, 2024 July, PMID: 39068167, PMCID: PMC11283523

Deberneh HM, Taylor ME, Borowik AK, Miyagi M, Miller BF, Sadygov RG. Numbers of Exchangeable Hydrogens from LC-MS Data of Heavy Water Metabolically Labeled Samples. J Am Soc Mass Spectrom, 2024 July, PMID: 39057601

Hense JD, Isola JVV, Garcia DN, Magalhães LS, Masternak MM, Stout MB, Schneider A. The role of cellular senescence in ovarian aging. NPJ Aging 10:35, 2024 July, PMID: 39033161, PMCID: PMC11271274

Schenk S, Sagendorf TJ, Many GM, Lira AK, de Sousa LGO, Bae D, Cicha M, Kramer KS, Muehlbauer M, Hevener AL, Rector RS, Thyfault JP, Williams JP, Goodyear LJ, Esser KA, Newgard CB, Bodine SC, MoTrPAC Study Group. Physiological Adaptations to Progressive Endurance Exercise Training in Adult and Aged Rats: Insights from the Molecular Transducers of Physical Activity Consortium (MoTrPAC). Function (Oxf) 5, 2024 July, PMID: 38984994, PMCID: PMC11245678

Wood TWP, Henriques WS, Cullen HB, Romero M, Blengini CS, Sarathy S, Sorkin J, Bekele H, Jin C, Kim S, Chemiakine A, Khondker RC, Isola JVV, Stout MB, Gennarino VA, Mogessie B, Jain D, Schindler K, Suh Y, Wiedenheft B, Berchowitz LE. The retrotransposon-derived capsid genes PNMA1 and PNMA4 maintain reproductive capacity. Res Sq, 2024 July, PMID: 39041030, PMCID: PMC11261967

Higgs MH, Beckstead MJ. Impact of unitary synaptic inhibition on spike timing in ventral tegmental area dopamine neurons. eNeuro, 2024 July, PMID: 38969500, PMCID: PMC11287791

Bubak MP, Davidyan A, O'Reilly CL, Mondal SA, Keast J, Doidge SM, Borowik AK, Taylor ME, Volovičeva E, Kinter MT, Britton SL, Koch LG, Stout MB, Lewis TL Jr, Miller BF. Metformin treatment results in distinctive skeletal muscle mitochondrial remodeling in rats with different intrinsic aerobic capacities. Aging Cell:e14235, 2024 June, PMID: 38923664, PMCID: PMC11488331

Kobak KA, Batushansky A, Jopkiewicz A, Peelor FF 3rd, Kinter MT, Miller BF, Griffin TM. Effect of biological sex and short-term high-fat diet on cellular proliferation, ribosomal biogenesis, and targeted protein abundance in murine articular cartilage. Osteoarthr Cartil Open 6:100495, 2024 June, PMID: 39040627, PMCID: PMC11260562

Camon C, Prescott M, Neyt C, Decourt C, Stout MB, Campbell RE, Garratt M. Systemic metabolic benefits of 17α-estradiol are not exclusively mediated by ERα in glutamatergic or GABAergic neurons. Geroscience, 2024 May, PMID: 38776045, PMCID: PMC11493872

Milan M, Brown J, O'Reilly CL, Bubak MP, Negri S, Balasubramanian P, Dhanekula AS, Pharaoh G, Reyff Z, Ballard C, Shi H, Yabluchanskiy A, Rudolph MC, Ungvari Z, Marcinek DJ, Miller BF, Van Remmen H, Tarantini S. Time-restricted feeding improves aortic endothelial relaxation by enhancing mitochondrial function and attenuating oxidative stress in aged mice. Redox Biol 73:103189, 2024 May, PMID: 38788541, PMCID: PMC11140804

Chucair-Elliott AJ, Ocañas SR, Pham K, Machalinski A, Plafker S, Stout MB, Elliott MH, Freeman WM. Age- and sex- divergent translatomic responses of the mouse retinal pigmented epithelium. Neurobiol Aging 140:41-59, 2024 May, PMID: 38723422, PMCID: PMC11173338

Isola JVV, Hense JD, Osorio CAP, Biswas S, Alberola-Ila J, Ocanas SR, Schneider A, Stout MB. Inflammation, immune cells, and cellular senescence in the aging ovary. Reproduction, 2024 May, PMID: 38744316, PMCID: PMC11301429

Many GM, Sanford JA, Sagendorf TJ, Hou Z, Nigro P, Whytock KL, Amar D, Caputo T, Gay NR, Gaul DA, Hirshman MF, Jimenez-Morales D, Lindholm ME, Muehlbauer MJ, Vamvini M, Bergman BC, Fernández FM, Goodyear LJ, Hevener AL, Ortlund EA, Sparks LM, Xia A, Adkins JN, Bodine SC, Newgard CB, Schenk S, MoTrPAC Study Group. Sexual dimorphism and the multi-omic response to exercise training in rat subcutaneous white adipose tissue. Nat Metab, 2024 May, PMID: 38693320, PMCID: PMC11132991

Amar D, Gay NR, Jimenez-Morales D, Jean Beltran PM, Ramaker ME, Raja AN, Zhao B, Sun Y, Marwaha S, Gaul DA, Hershman SG, Ferrasse A, Xia A, Lanza I, Fernández FM, Montgomery SB, Hevener AL, Ashley EA, Walsh MJ, Sparks LM, Burant CF, Rector RS, Thyfault J, Wheeler MT, Goodpaster BH, Coen PM, Schenk S, Bodine SC, Lindholm ME, MoTrPAC Study Group. The mitochondrial multi-omic response to exercise training across rat tissues. Cell Metab, 2024 April, PMID: 38701776, PMCID: PMC11152996

Chakraborty P, Niewiadomska M, Farhat K, Morris L, Whyte S, Humphries KM, Stavrakis S. Effect of Low-Level Tragus Stimulation on Cardiac Metabolism in Heart Failure with Preserved Ejection Fraction: A Transcriptomics-Based Analysis. Int J Mol Sci 25, 2024 April, PMID: 38673896, PMCID: PMC11050145

Harold KM, Matsuzaki S, Pranay A, Loveland BL, Batushansky A, Mendez Garcia MF, Eyster C, Stavrakis S, Chiao YA, Kinter M, Humphries KM. Loss of Cardiac PFKFB2 Drives Metabolic, Functional, and Electrophysiological Remodeling in the Heart. J Am Heart Assoc 13:e033676, 2024 April, PMID: 38533937, PMCID: PMC11179765

Chen J, Ding Y, Jiang C, Qu R, Wren JD, Georgescu C, Wang X, Reuter DN, Liu B, Giles CB, Mayr CH, Schiller HB, Dai J, Stipp CS, Subramaniyan B, Wang J, Zuo H, Huang C, Fung KM, Rice HC, Sonnenberg A, Wu D, Walters MS, Zhao YY, Kanie T, Hays FA, Papin JF, Wang DW, Zhang XA. CD151 Maintains Endolysosomal Protein Quality to Inhibit Vascular Inflammation. Circ Res, 2024 April, PMID: 38557119, PMCID: PMC11081830

Noh JY, Farhataziz N, Kinter MT, Yan X, Sun Y. Colonic Dysregulation of Major Metabolic Pathways in Experimental Ulcerative Colitis. Metabolites 14, 2024 March, PMID: 38668322, PMCID: PMC11052278

Palakshappa JA, Batt JAE, Bodine SC, Connolly BA, Doles J, Falvey JR, Ferrante LE, Files DC, Harhay MO, Harrell K, Hippensteel JA, Iwashyna TJ, Jackson JC, Lane-Fall MB, Monje M, Moss M, Needham DM, Semler MW, Lahiri S, Larsson L, Sevin CM, Sharshar T, Singer B, Stevens T, Taylor SP, Gomez CR, Zhou G, Girard TD, Hough CL. Tackling Brain and Muscle Dysfunction in Acute Respiratory Distress Syndrome Survivors: National Heart, Lung, and Blood Institute Workshop Report. Am J Respir Crit Care Med, 2024 March, PMID: 38477657, PMCID: PMC11146564

Virga DM, Hamilton S, Osei B, Morgan A, Kneis P, Zamponi E, Park NJ, Hewitt VL, Zhang D, Gonzalez KC, Russell FM, Grahame Hardie D, Prudent J, Bloss E, Losonczy A, Polleux F, Lewis TL Jr. Activity-dependent compartmentalization of dendritic mitochondria morphology through local regulation of fusion-fission balance in neurons in vivo. Nat Commun 15:2142, 2024 March, PMID: 38459070, PMCID: PMC10923867

Hinton A Jr, Katti P, Mungai M, Hall DD, Koval O, Shao J, Vue Z, Lopez EG, Rostami R, Neikirk K, Ponce J, Streeter J, Schickling B, Bacevac S, Grueter C, Marshall A, Beasley HK, Do Koo Y, Bodine SC, Nava NGR, Quintana AM, Song LS, Grumbach IM, Pereira RO, Glancy B, Abel ED. ATF4-dependent increase in mitochondrial-endoplasmic reticulum tethering following OPA1 deletion in skeletal muscle. J Cell Physiol, 2024 February, PMID: 38419397, PMCID: PMC11144302

Ohene-Marfo P, Nguyen HVM, Mohammed S, Thadathil N, Tran A, Nicklas EH, Wang D, Selvarani R, Farriester JW, Varshney R, Kinter M, Richardson A, Rudolph MC, Deepa SS. Non-Necroptotic Roles of MLKL in Diet-Induced Obesity, Liver Pathology, and Insulin Sensitivity: Insights from a High-Fat, High-Fructose, High-Cholesterol Diet Mouse Model. Int J Mol Sci 25, 2024 February, PMID: 38474061, PMCID: PMC10931720

Hirabayashi Y, Lewis TL Jr, Du Y, Virga DM, Decker AM, Coceano G, Alvelid J, Paul MA, Hamilton S, Kneis P, Takahashi Y, Gaublomme JT, Testa I, Polleux F. Most axonal mitochondria in cortical pyramidal neurons lack mitochondrial DNA and consume ATP. bioRxiv, 2024 February, PMID: 38405915, PMCID: PMC10888904

Deepa SS, Thadathil N, Corral J, Mohammed S, Pham S, Rose H, Kinter MT, Richardson A, Díaz-García CM. MLKL overexpression leads to Ca(2 ) and metabolic dyshomeostasis in a neuronal cell model. Cell Calcium 119:102854, 2024 February, PMID: 38430790, PMCID: PMC10990772

Veiga GB, Zanini BM, Garcia DN, Hense JD, Barreto MM, Isola JVV, Mondadori RG, Masternak MM, Stout MB, Schneider A. Effects of calorie, protein, and branched chain amino acid restriction on ovarian aging in mice. Reprod Biol 24:100856, 2024 January, PMID: 38295721, PMCID: PMC10978239

Larson KR, Jayakrishnan D, Soto Sauza KA, Goodson ML, Chaffin AT, Davidyan A, Pathak S, Fang Y, Gonzalez Magaña D, Miller BF, Ryan KK. FGF21 induces skeletal muscle atrophy and increases amino acids in female mice: a potential role for glucocorticoids. Endocrinology, 2024 January, PMID: 38244215, PMCID: PMC10849119

Borowik AK, Lawrence MM, Peelor FF 3rd, Piekarz KM, Crosswhite A, Richardson A, Miller BF, Van Remmen H, Brown JL. Senolytic treatment does not mitigate oxidative stress-induced muscle atrophy but improves muscle force generation in CuZn superoxide dismutase knockout mice. Geroscience, 2024 January, PMID: 38233728, PMCID: PMC11009189

Muñoz-Oreja M, Sandoval A, Bruland O, Perez-Rodriguez D, Fernandez-Pelayo U, de Arbina AL, Villar-Fernandez M, Hernández-Eguiazu H, Hernández I, Park Y, Goicoechea L, Pascual-Frías N, Garcia-Ruiz C, Fernandez-Checa J, Martí-Carrera I, Gil-Bea FJ, Hasan MT, Gegg ME, Bredrup C, Knappskog PM, Gereñu-Lopetegui G, Varhaug KN, Bindoff LA, Spinazzola A, Yoon WH, Holt IJ. Elevated cholesterol in ATAD3 mutants is a compensatory mechanism that leads to membrane cholesterol aggregation. Brain, 2024 January, PMID: 38242545, PMCID: PMC11068212

Isola JVV, Ocañas SR, Hubbart CR, Ko S, Mondal SA, Hense JD, Carter HNC, Schneider A, Kovats S, Alberola-Ila J, Freeman WM, Stout MB. A single-cell atlas of the aging mouse ovary. Nat Aging, 2024 January, PMID: 38200272, PMCID: PMC10798902

Bubak MP, Mann SN, Borowik AK, Pranay A, Batushansky A, Vieira de Sousa Neto I, Ali Mondal SA, Doidge SM, Davidyan A, Szczygiel MM, Peelor Iii FF, Rigsby S, Broomfield ME, Lacy CI, Rice HC, Stout MB, Miller BF. 17α-estradiol Alleviates High-Fat Diet-Induced Inflammatory and Metabolic Dysfunction in Skeletal Muscle of Male and Female Mice. Am J Physiol Endocrinol Metab, 2024 January, PMID: 38197793, PMCID: PMC11193529

Aging & Metabolism Research Program
Oklahoma Medical Research Foundation
825 NE 13th Street, MS 21
Oklahoma City, OK 73104

Phone: (405) 271-7570
Fax: (405) 271-1437
Email: Jeannie-Evans@omrf.org