2017 Scientific Publications

Advanced Magnetic Resonance Center

*Barboza E, Hudson J, Chang WP, Kovats S, Towner RA, Silasi-Mansat R, Lupu F, Kent C, Griffin TM. Pro-fibrotic infrapatellar fat pad remodeling without M1-macrophage polarization precedes knee osteoarthritis in diet-induced obese mice. Arthritis Rheumatol. 2017 Jun;69(6):1221-32. PMCID: PMC5449220

Dong Y, Fernandes C, Liu Y, Wu Y, Wu H, Brophy ML, Deng L, Song K, Wen A, Wong S, Yan D, Towner R, Chen H. Role of endoplasmic reticulum stress signaling in diabetic endothelial dysfunction and atherosclerosis. Diab Vasc Dis Res. 2017 Jan;14(1):14-23. Review. PMCID: PMC5161113

*Hopiavuori BR, Deák F, Wilkerson JL, Brush RS, Rocha-Hopiavuori NA, Hopiavuori AR, Ozan KG, Sullivan MT, Wren JD, Georgescu C, Szweda L, Awasthi V, Towner R, Sherry DM, Anderson RE, Agbaga MP. Homozygous Expression of Mutant ELOVL4 Leads to Seizures and Death in a Novel Animal Model of Very Long-Chain Fatty Acid Deficiency. Mol Neurobiol. 2017 Nov 22. PMID: 29168048

Towner R, Smith N. In vivo and in situ detection of macromolecular free radicals using immuno-spin trapping and molecular MRI. Antioxid Redox Signal. 2017 Oct 30. PMID:29084431

Ziegler J, Bastian A, Lerner M, Bailey-Downs L, Saunders D, Smith N, Sutton J, Battiste JD, Ihnat MA, Gangjee A, Towner RA. AG488 as a therapy against gliomas. Oncotarget. 2017 May 30. [Epub ahead of print] PMID: 28621261

Aging and Metabolism Research Program

Bastian A, Matsuzaki S, Humphries KM, Pharaoh GA, Doshi A, Zaware N, Gangjee A, Ihnat MA. AG311, a small molecule inhibitor of complex I and hypoxia-induced HIF-1α stabilization. Cancer Lett. 2017 Mar 1;388:149-57. PMCID: PMC5318233

Bhaskaran S, Unnikrishnan A, Ranjit R, Qaisar R, Pharaoh G, Matyi S, Kinter M, Deepa SS. A fish oil diet induces mitochondrial uncoupling and mitochondrial unfolded protein response in epididymal white adipose tissue of mice. Free Radic Biol Med. 2017 Apr 26;108:704-14. Epub ahead of print. PMID: 28455142

Chen M, Nowak DG, Narula N, Robinson B, Watrud K, Ambrico A, Herzka TM, Zeeman ME, Minderer M, Zheng W, Ebbesen SH, Plafker KS, Stahlhut C, Wang VM, Wills L, Nasar A, Castillo-Martin M, Cordon-Cardo C, Wilkinson JE, Powers S, Sordella R, Altorki NK, Mittal V, Stiles BM, Plafker SM, Trotman LC. The nuclear transport receptor Importin-11 is a tumor suppressor that maintains PTEN protein. J Cell Biol. 2017 Mar 6;216(3):641-56. Epub 2017 Feb 13. PMCID: PMC5350510

Deepa SS, Bhaskaran S, Espinoza S, Brooks SV, McArdle A, Jackson MJ, Van Remmen H, Richardson A. A new mouse model of frailty: the Cu/Zn superoxide dismutase knockout mouse. Geroscience. 2017 Apr;39(2):187-98. PMCID: PMC5411367

Fu Z, Löfqvist CA, Liegl R, Wang Z, Sun Y, Gong Y, Liu CH, Meng SS, Burnim SB, Arellano I, Chouinard MT, Duran R, Poblete A, Cho SS, Akula JD, Kinter M, Ley D, Pupp IH, Talukdar S, Hellström A, Smith LE. Photoreceptor glucose metabolism determines normal retinal vascular growth. EMBO Mol Med. 2017 Nov 27. pii: e201707966. PMID:29180355

Hill S, Deepa SS, Sataranatarajan K, Premkumar P, Pulliam D, Liu Y, Soto VY, Fischer KE, Van Remmen H. Sco2 deficient mice develop increased adiposity and insulin resistance. Mol Cell Endocrinol. 2017 Apr 18. pii: S0303-7207(17)30190-9. Epub ahead of print. PMID: 28428045

Kalaitzoglou E, Griffin TM, Humphrey MB. Innate Immune Responses and Osteoarthritis. Curr Rheumatol Rep. 2017 Aug;19(8):45. Review. PMID: 28718060

Pearsall EA, Cheng R, Zhou K, Takahashi Y, Matlock HG, Vadvalkar SS, Shin Y, Fredrick TW, Gantner ML, Meng S, Fu Z, Gong Y, Kinter M, Humphries KM, Szweda LI, Smith LEH, Ma JX. PPARα is essential for retinal lipid metabolism and neuronal survival. BMC Biol. 2017 Nov 28;15(1):113.PMCID:PMC5706156

Sandoval IT, Delacruz RG, Miller BN, Hill S, Olson KA, Gabriel AE, Boyd K, Satterfield C, Remmen HV, Rutter J, Jones DA. A metabolic switch controls intestinal differentiation downstream of Adenomatous polyposis coli (APC). Elife. 2017 Apr 11;6. pii: e22706. PMCID: PMC5388534

Sakellariou G, McDonagh B, Porter H, Giakoumaki I, Earl K, Nye G, Vasilaki A, Brooks S, Richardson A, Van Remmen H, McArdle A, Jackson MJ. Comparison of whole body SOD1 knockout with muscle specific SOD1 knockout mice reveals a role for nerve redox signaling in regulation of degenerative pathways in skeletal muscle. Antioxid Redox Signal. 2017 Oct 25. PMID:29065712

Vadvalkar SS, Matsuzaki S, Eyster CA, Giorgione JR, Bockus LB, Kinter CS, Kinter M, Humphries KM. Decreased Mitochondrial Pyruvate Transport Activity in the Diabetic Heart: role of mitrochondrial pyruvate carrier 2 (MPC2) acetylation. J Biol Chem. 2017 Mar 17;292(11):4423-33. PMCID: PMC537776

Walsh ME, Van Remmen H. Emerging roles for histone deacetylases in age-related muscle atrophy. Nutr Healthy Aging. 2016 Oct 27;4(1):17-30. Review. PMCID: PMC5166515

Zahra A, Fath MA, Opat E, Mapuskar KA, Bhatia SK, Ma DC, Iii SNR, Snyders TP, Chenard CA, Eichenberger-Gilmore JM, Bodeker KL, Ahmann L, Smith BJ, Vollstedt SA, Brown HA, Hejleh TA, Clamon GH, Berg DJ, Szweda LI, Spitz DR, Buatti JM, Allen BG. Consuming a Ketogenic Diet while Receiving Radiation and Chemotherapy for Locally Advanced Lung Cancer and Pancreatic Cancer: The University of Iowa Experience of Two Phase 1 Clinical Trials. Radiat Res. 2017 Jun;187(6):743-54. PMID: 28437190

Zhang N, Valentine JM, Zhou Y, Li ME, Zhang Y, Bhattacharya A, Walsh ME, Fischer KE, Austad SN, Osmulski P, Gaczynska M, Shoelson SE, Van Remmen H, Chen HI, Chen Y, Liang H, Musi N. Sustained NFκB inhibition improves insulin sensitivity but is detrimental to muscle health. Aging Cell. 2017 May 29. [Epub ahead of print] PMID: 28556540

Arthritis and Clinical Immunology Research Program

Aberle T, Bourn RL, Chen H, Roberts VC, Guthridge JM, Bean K, Robertson JM, Sivils KL, Rasmussen A, Liles M, Merrill JT, Harley JB, Olsen NJ, Karp DR, James JA. Use of SLICC criteria in a large, diverse lupus registry enables SLE classification of a subset of ACR-designated subjects with incomplete lupus. Lupus Sci Med. 2017 Mar 17;4(1):e000176. eCollection 2017. PMCID: PMC5372139

Aberle T, Bourn RL, Munroe ME, Chen H, Roberts VC, Guthridge JM, Bean K, Robertson JM, Sivils KL, Rasmussen A, Liles M, Merrill JT, Harley JB, Olsen NJ, Karp DR, James JA. Clinical and serological features distinguish patients with incomplete lupus classification from systemic lupus erythematosus patients and controls. Arthritis Care Res (Hoboken). 2017 Dec;69(12):1780-8. PMCID: PMC5524597

Adrianto I, Montgomery C. Estimating Allele Frequencies. Methods Mol Biol. 2017;1666:61-81. PMID:28980242

Ainsworth HC, Marion MC, Bertero T, Brucato A, Cimaz R, Costedoat-Chalumeau N, Fredi M, Gaffney P, Kelly J, Levesque K, Maltret A, Morel N, Ramoni V, Ruffatti A, Langefeld CD, Buyon JP, Clancy RM. Association of Natural Killer Cell Ligand Polymorphism HLA-C Asn80Lys with the Development of Anti-SSA/Ro-Associated Congenital Heart Block. Arthritis Rheumatol. 2017 Nov;69(11):2170-4. PMCID:PMC5679096

Arriens C, Chen S, Karp DR, Saxena R, Sambandam K, Chakravarty E, James JA, Merrill JT. Prognostic significance of repeat biopsy in lupus nephritis: Histopathologic worsening and a short time between biopsies is associated with significantly increased risk for end stage renal disease and death. Clin Immunol. 2016 Dec 3. pii: S1521-6616(16)30668-4. Epub ahead of print. PMCID: PMC5457715

Arriens C, Wren JD, Munroe ME, Mohan C. Systemic lupus erythematosus biomarkers: the challenging quest. Rheumatology (Oxford). 2017 Apr 1;56(suppl_1):i32-i45. PMID: 28013203

Askanase AD, Nguyen SC, Costenbader K, Lim SS, Kamen D, Aranow C, Grossman J, Kapoor TM, Baker-Frost D, Aberle T, Thanou-Stavraki A, Hanrahan LM, Kim M, Merrill JT. A Rapid Evaluation of Activity in Lupus (LFA-REAL^™) Correlates with More Complex Disease Activity Instruments Whether Evaluated by Clinical Investigators or Real-World Clinicians. Arthritis Care Res (Hoboken). 2017 Oct 9. PMID:28992399

Bandyopadhyay S, Connolly SE, Jabado O, Ye J, Kelly S, Maldonado MA, Westhovens R, Nash P, Merrill JT, Townsend RM. Identification of biomarkers of response to abatacept in patients with SLE using deconvolution of whole blood transcriptomic data from a phase IIb clinical trial. Lupus Sci Med. 2017 Jul 28;4(1):e000206. PMCID: PMC5704740

Basu A, Schell J, Scofield RH. Dietary fruits and arthritis. Food Funct. 2017 Dec 11. Review. PMID: 29227497

Berkovich R, Bakshi R, Amezcua L, Axtell RC, Cen SY, Tauhid S, Neema M, Steinman L. Adrenocorticotropic hormone versus methylprednisolone added to interferon β in patients with multiple sclerosis experiencing breakthrough disease: a randomized, rater-blinded trial. Ther Adv Neurol Disord. 2017 Jan;10(1):3-17. PMCID: PMC5400152

Bernatsky S, …, Gaffney P, Smedby KE, et al. Lupus-related single nucleotide polymorphisms and risk of diffuse large B-cell lymphoma. Lupus Sci Med. 2017 Nov 12;4(1):e000187. PMCID: PMC5715504

Bockus LB, Matsuzaki S, Vadvalkar SS, Young ZT, Giorgione JR, Newhardt MF, Kinter M, Humphries KM. Cardiac Insulin Signaling Regulates Glycolysis Through Phosphofructokinase 2 Content and Activity. J Am Heart Assoc. 2017 Dec 4;6(12). pii: e007159. PMID: 29203581

Braun DA, Rao J, Mollet G, …, Gaffney PM, et al. Mutations in KEOPS-complex genes cause nephrotic syndrome with primary microcephaly. Nat Genet. 2017 Oct;49(10):1529-38. PMID:28805828

Buckley DA, Jennings EM, Burke NN, Roche M, McInerney V, Wren JD, Finn DP, McHugh PC. Erratum to: The Development of Translational Biomarkers as a Tool for Improving the Understanding, Diagnosis and Treatment of Chronic Neuropathic Pain. Mol Neurobiol. 2017 Jul 1. [Epub ahead of print] PMID: 28669124

Carapito R, Gottenberg JE, Kotova I, Untrau M, Michel S, Naegely L, Aouadi I, Kwemou M, Paul N, Pichot A, Locke J, Bowman SJ, Griffiths B, Sivils KL, Sibilia J, Inoko H, Micelli-Richard C, Nocturne G, Ota M, Ng WF, Mariette X, Bahram S. A new MHC-linked susceptibility locus for primary Sjögren’s syndrome: MICA. Hum Mol Genet. 2017 Apr 4. Epub ahead of print. PMID: 28379387

Choi MY, Clarke AE, St Pierre Y, Hanly JG, Urowitz MB, Romero-Diaz J, Gordon C, Bae SC, Bernatsky S, Wallace DJ, Merrill JT, Isenberg DA, Rahman A, Ginzler EM, Petri M, Bruce IN, Dooley MA, Fortin P, Gladman DD, Sanchez-Guerrero J, Steinsson K, Ramsey-Goldman R, Khamashta MA, Aranow C, Alarcón GS, Manzi S, Nived O, Zoma AA, van Vollenhoven RF, Ramos-Casals M, Ruiz-Irastorza G, Lim SS, Kalunian KC, Inanc M, Kamen DL, Peschken CA, Jacobsen S, Askanase A, Buyon J, Mahler M, Fritzler MJ. The prevalence and determinants of anti-DFS70 autoantibodies in an international inception cohort of systemic lupus erythematosus patients. Lupus. 2017 Jan 1:961203317692437. Epub ahead of print. PMID: 28420054

Danda D, Goel R, Danda S, Mohan H, Joseph G, Kabeerdoss J, Nath SK. Interleukin-17F and Interleukin-6 gene polymorphisms in Asian Indian patients with Takayasu arteritis. Hum Immunol. 2017 Apr 21. pii: S0198-8859(17)30070-8. Epub ahead of print. PMID: 28438554

Danda D, Sharma R, Truong D, Koelsch KA, Kurien BT, Bagavant H, Deshmukh U, Kaufman CE, Lewis DM, Stone DU, Radfar L, Rasmussen A, Sivils KL, Scofield RH. Anti-La positive, anti-Ro negative subset of primary Sjögren’s syndrome: anti-La is a reality but is the disease? Clin Exp Rheumatol. 2017 Feb 20. Epub ahead of print. PMID: 28229827

Dumas EK, Garman L, Cuthbertson H, Charlton S, Hallis B, Engler RJM, Choudhari S, Picking WD, James JA, Farris AD. Lethal factor antibodies contribute to lethal toxin neutralization in recipients of anthrax vaccine precipitated. Vaccine. 2017 Jun 8;35(26):3416-22. Epub 2017 May 11. PMID: 28504191

Ferreira I, Croca S, Raimondo MG, …, Merrill J, et al. Nitrated nucleosome levels and neuropsychiatric events in systemic lupus erythematosus; a multi-center retrospective case-control study. Arthritis Res Ther. 2017 Dec 22;19(1):287. PMID:29273092

*Fields E, Wren JD, Georgescu C, Daum JR, Gorbsky GJ. Predictive bioinformatics identifies novel regulators of proliferation in a cancer stem cell model. Stem Cell Res. 2017 Nov 21;26:1-7. PMID:29179130

Furie R, Khamashta M, Merrill JT, Werth VP, Kalunian K, Brohawn P, Illei GG, Drappa J, Wang L, Yoo S; CD1013 Study Investigators. Anifrolumab, an Anti-Interferon-α Receptor Monoclonal Antibody, in Moderate-to-Severe Systemic Lupus Erythematosus. Arthritis Rheumatol. 2017 Feb;69(2):376-86. PMCID: PMC5299497

Garbett NC, Brock GN, Chaires JB, Mekmaysy CS, DeLeeuw L, Sivils KL, Harley JB, Rovin BH, Kulasekera KB, Jarjour WN. Characterization and classification of lupus patients based on plasma thermograms. PLoS One. 2017 Nov 17;12(11):e0186398. PMCID:PMC5693473

Gensterblum E, Renauer P, Coit P, Strickland FM, Kilian NC, Miller S, Ognenovski M, Wren JD, Tsou PS, Lewis EE, Maksimowicz-McKinnon K, McCune WJ, Richardson BC, Sawalha AH. CD4+CD28+KIR+CD11a^hi T cells correlate with disease activity and are characterized by a pro-inflammatory epigenetic and transcriptional profile in lupus patients. J Autoimmun. 2017 Oct 20. pii: S0896-8411(17)30596-6. PMID:29066026

Giles CB, Brown CA, Ripperger M, Dennis Z, Roopnarinesingh X, Porter H, Perz A, Wren JD. ALE: automated label extraction from GEO metadata. BMC Bioinformatics. 2017 Dec 28;18(Suppl 14):509. PMID:29297276

Glauzy S, Boccitto M, Bannock JM, Delmotte FR, Saadoun D, Cacoub P, Ice JA, Sivils KL, James JA, Wolin SL, Meffre E. Antigen-driven lymphoproliferations in Sjögren’s Syndrome patients accumulate in complement receptor 2/CD21^-/low B cells. Arthritis Rheumatol. 2017 Oct 26. PMID:29073352

Gough AT, Fieraru G, Gaffney P, Butler M, Kincaid RJ, Middleton RG. A novel use of QR code stickers after orthopaedic cast application. Ann R Coll Surg Engl. 2017 Jul;99(6):476-8. PMID: 28660817

Harris VM, Sharma R, Cavett J, Kurien BT, Liu K, Koelsch KA, Rasmussen A, …, Lessard CJ, Harley JB, Sivils KL, Scofield HR. Corrigendum to “Klinefelter’s syndrome (47,XXY) is in excess among men with Sjögren’s syndrome” Clin Immunol. 2017 Nov 28. pii: S1521-6616(17)30854-9. PMID:29195081

He X, Cheng R, Park K, Benyajati S, Moiseyev G, Sun C, Olson LE, Yang Y, Eby BK, Lau K, Ma JX. Pigment epithelium-derived factor, a noninhibitory serine protease inhibitor, is renoprotective by inhibiting the Wnt pathway. Kidney Int. 2017 Mar;91(3):642-57. PMCID:PMC5313326

Heinlen L, Chakravarty EF. Reproductive Health Screening in Women with Autoimmune Diseases. Rheum Dis Clin North Am. 2017 May;43(2):161-71. Review. PMID:28390560

Isenberg D, Sturgess J, Allen E, …, Merrill J, Gordon C. A study of flare assessment in systemic lupus erythematosus (SLE) based on paper patients. Arthritis Care Res (Hoboken). 2017 Apr 7. Epub ahead of print. PMID: 28388813

Jog NR, James JA. Biomarkers in connective tissue diseases. J Allergy Clin Immunol. 2017 Dec;140(6):1473-1483. Review. PMID: 29221579

Kalunian KC, Urowitz MB, Isenberg D, Merrill JT, Petri M, Furie RA, Morgan-Cox MA, Taha R, Watts S, Silk M, Linnik MD. Clinical trial parameters that influence outcomes in lupus trials that use the systemic lupus erythematosus responder index. Rheumatology (Oxford). 2017 Oct 17. PMID:29045736

Kaplowitz ET, Ferguson S, Guerra M, Laskin CA, Buyon JP, Petri M, Lockshin MD, Sammaritano LR, Branch DW, Merrill JT, Katz P, Salmon JE. Socioeconomic Status Contributes to Racial/Ethnic Disparities in Adverse Pregnancy Outcomes among Women with Systemic Lupus Erythematosus. Arthritis Care Res (Hoboken). 2017 May 8. Epub ahead of print. PMID: 28480528

Kim M, Merrill J, Kalunian K, Hahn B, Roach A, Izmirly P; Lupus Foundation of America Collective Data Analysis Initiative Group.. Brief Report: Longitudinal Patterns of Response to Standard of Care Therapy for Systemic Lupus Erythematosus: Implications for Clinical Trial Design. Arthritis Rheumatol. 2017 Apr;69(4):785-90. PMID: 27992696

Kishi T, Rider LG, Pak K, Barillas-Arias L, Henrickson M, McCarthy PL, Shaham B, Weiss PF, Horkayne-Szakaly I, Targoff IN, Miller FW, Mammen AL; Childhood Myositis Heterogeneity Study Group.. Anti-3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase Autoantibodies are Associated with DRB1*07:01 and Severe Myositis in Pediatric Myositis Patients. Arthritis Care Res (Hoboken). 2017 Jan 27. Epub ahead of print. PMID: 28129483

Kolstad KD, Fiorentino D, Li S, Chakravarty EF, Chung L. Pregnancy outcomes in adult patients with dermatomyositis and polymyositis. Semin Arthritis Rheum. 2017 Nov 20. pii: S0049-0172(17):30316-5. PMID: 29217291

Kurien BT, Matsumoto H, Scofield RH. Nutraceutical Value of Pure Curcumin. Pharmacogn Mag. 2017 Jan;13(Suppl 1):S161-63. PMCID: PMC5407110

Kurien BT, Scofield RH. Validating Antibody Specificities for Immunohistochemistry by Protein Blotting Methods. Methods Mol Biol. 2017;1554:61-73. PMID: 28185183

Landrian I, McFarland KN, Liu J, Mulligan CJ, Rasmussen A, Ashizawa T. Inheritance patterns of ATCCT repeat interruptions in spinocerebellar ataxia type 10 (SCA10) expansions. PLoS One. 2017 Apr 19;12(4):e0175958. eCollection 2017. PMCID: PMC5397023

Langefeld CD, Ainsworth HC, Cunninghame Graham DS, …Guthridge JM, Huggins JL, James JA, … Merrill JT, Miranda P, Moctezuma JF, Nath SK, … Sivils KL, … Alarcón-Riquelme ME, …, Gaffney PM, Vyse TJ. Transancestral mapping and genetic load in systemic lupus erythematosus. Nat Commun. 2017 Jul 17;8:16021. PMCID: PMC5520018

Leehan KM, Pezant NP, Rasmussen A, Grundahl K, Moore JS, Radfar L, Lewis DM, Stone DU, Lessard CJ, Rhodus NL, Segal BM, Kaufman CE, Scofield RH, Sivils KL, Montgomery C, Farris AD. Fatty infiltration of the minor salivary glands is a selective feature of aging but not Sjögren’s syndrome. Autoimmunity. 2017 Oct 8:1-7. PMID:28988489

Leehan KM, Pezant NP, Rasmussen A, Grundahl K, Moore JS, Radfar L, Lewis DM, Stone DU, Lessard CJ, Rhodus NL, Segal BM, Scofield RH, Sivils KL, Montgomery C, Farris AD. Minor salivary gland fibrosis in Sjögren’s syndrome is elevated, associated with focus score and not solely a consequence of aging. Clin Exp Rheumatol. 2017 Oct 23. PMID: 29148407

Li H, Reksten TR, Ice JA,…, Farris AD, B…, Gaffney PM, James JA, Turner S, Alevizos I, Anaya JM, Rhodus NL, Segal BM, Montgomery CG, Scofield RH, Kovats S, …., Lessard CJ, Sivils KL. Identification of a Sjögren’s syndrome susceptibility locus at OAS1 that influences isoform switching, protein expression, and responsiveness to type I interferons. PLoS Genet. 2017 Jun 22;13(6):e1006820. Epub ahead of print. PMID: 28640813

Manzi S, Merrill J. Editorial: Lupus, the Chameleon: Many Disguises Difficult to Capture. Arthritis Rheumatol. 2017 Oct;69(10):1921-4. PMID:28891123

Mariette X, Förger F, Abraham B, Flynn AD, Moltó A, Flipo RM, van Tubergen A, Shaughnessy L, Simpson J, Teil M, Helmer E, Wang M, Chakravarty EF. Lack of placental transfer of certolizumab pegol during pregnancy: results from CRIB, a prospective, postmarketing, pharmacokinetic study. Ann Rheum Dis. 2017 Oct 13. pii: annrheumdis-2017-212196. PMID:29030361

Molineros JE, Yang W, Zhou XJ, Sun C, Okada Y, Zhang H, Heng Chua K, Lau YL, Kochi Y, Suzuki A, Yamamoto K, Ma J, Bang SY, Lee HS, Kim K, Bae SC, Zhang H, Shen N, Looger LL, Nath SK. Confirmation of five novel susceptibility loci for systemic lupus erythematosus (SLE) and integrated network analysis of 82 SLE susceptibility loci. Hum Mol Genet. 2017 Mar 15;26(6):1205-16. PMID: 28108556

Moller DR, Rybicki BA, Hamzeh NY, Montgomery CG, Chen ES, Drake W, Fontenot AP. Genetic, Immunologic, and Environmental Basis of Sarcoidosis. Ann Am Thorac Soc. 2017 Dec;14(Supplement_6):S429-36. PMID:29073364

Munroe ME, Vista ES, Merrill JT, Guthridge JM, Roberts VC, James JA. Pathways of impending disease flare in African-American systemic lupus erythematosus patients. J Autoimmun. 2017 Mar;78:70-8. PMCID: PMC5340190

Piccini A, Castroflorio E, Valente P, Guarnieri FC, Aprile D, Michetti C, Bramini M, Giansante G, Pinto B, Savardi A, Cesca F, Bachi A, Cattaneo A, Wren JD, Fassio A, Valtorta F, Benfenati F, Giovedì S. APache Is an AP2-Interacting Protein Involved in Synaptic Vesicle Trafficking and Neuronal Development. Cell Rep. 2017 Dec 19;21(12):3596-3611. PMID:29262337

Pardo G, Jones DE. The sequence of disease-modifying therapies in relapsing multiple sclerosis: safety and immunologic considerations. J Neurol. 2017 Dec;264(12):2351-74. Review. Erratum in: J Neurol. 2017 Dec;264(12 ):2375-7.PMCID:PMC5688209

Patel VI, Booth JL, Duggan ES, Cate S, White VL, Hutchings D, Kovats S, Burian DM, Dozmorov M, Metcalf JP. Transcriptional Classification and Functional Characterization of Human Airway Macrophage and Dendritic Cell Subsets. J Immunol. 2017 Feb 1;198(3):1183-1201. PMCID:PMC5262539

Schell J, Betts NM, Foster M, Scofield RH, Basu A. Cranberries improve postprandial glucose excursions in type 2 diabetes. Food Funct. 2017 Jul 27. Epub ahead of print. PMID: 28748974

Sharma R, Harris VM, Cavett J, …, Lessard CJ, Harley JB, Ng WF, Rasmussen A, Sivils KL, Scofield RH. Rare X Chromosome Abnormalities in Systemic Lupus Erythematosus and Sjögren’s Syndrome. Arthritis Rheumatol. 2017 Nov;69(11):2187-92. PMID: 28692793

Shirley E, Chakravarty EF. The Herpes Zoster Vaccine in Rheumatic Diseases: Duration of Response. J Rheumatol. 2017 Jul;44(7):968-9. PMID: 28668813

*Siefert JC, Georgescu C, Wren JD, Koren A, Sansam CL. DNA replication timing during development anticipates transcriptional programs and parallels enhancer activation. Genome Res. 2017 May 16. pii: gr.218602.116. Epub ahead of print. PMID: 28512193

Stone DU, Fife D, Brown M, Earley KE, Radfar L, Kaufman CE, Lewis DM, Rhodus NL, Segal BM, Wallace DJ, Weisman MH, Venuturupalli S, Brennan MT, Lessard CJ, Montgomery CG, Scofield RH, Sivils KL, Rasmussen A. Effect of Tobacco Smoking on The Clinical, Histopathological, and Serological Manifestations of Sjögren’s Syndrome. PLoS One. 2017 Feb 6;12(2):e0170249. PMCID: PMC5293551

Talsania M, Sharma R, Sughrue ME, Scofield RH, Lim J. Familial Pallister-Hall in adulthood. Neuro Endocrinol Lett. 2017 Oct;38(5):329-331. PMID: 29106787

*Tipton AR, Wren JD, Daum JR, Siefert JC, Gorbsky GJ. GTSE1 regulates spindle microtubule dynamics to control Aurora B kinase and Kif4A chromokinesin on chromosome arms. J Cell Biol. 2017 Oct 2;216(10):3117-32. PMCID:PMC5626529

Troyanov Y, Landon-Cardinal O, Fritzler MJ, Ferreira J, Targoff IN, Rich E, Goulet M, Goulet JR, Bourré-Tessier J, Robitaille Y, Drouin J, Albert A, Senécal JL. Atorvastatin-induced necrotizing autoimmune myositis: An emerging dominant entity in patients with autoimmune myositis presenting with a pure polymyositis phenotype. Medicine (Baltimore). 2017 Jan;96(3):e5694. PMCID: PMC5279076

Tung KS, Harakal J, Qiao H, Rival C, Li JC, Paul AG, Wheeler K, Pramoonjago P, Grafer CM, Sun W, Sampson RD, Wong EW, Reddi PP, Deshmukh US, Hardy DM, Tang H, Cheng CY, Goldberg E. Egress of sperm autoantigen from seminiferous tubules maintains systemic tolerance. J Clin Invest. 2017 Mar 1;127(3):1046-60. PMCID: PMC5330742

Unnikrishnan A, Jackson J, Matyi SA, Hadad N, Wronowski B, Georgescu C, Garrett KP, Wren JD, Freeman WM, Richardson A. Role of DNA methylation in the dietary restriction mediated cellular memory. Geroscience. 2017 May 5. Epub ahead of print. PMID: 28477138

Vista ES, Weisman MH, Ishimori ML, Chen H, Bourn RL, Bruner BF, Hamijoyo L, Tanangunan RD, Gal NJ, Robertson JM, Harley JB, Guthridge JM, Navarra SV, James JA. Strong viral associations with SLE among Filipinos. Lupus Sci Med. 2017 Jul 28;4(1):e000214. PMCID: PMC5704743

Wang HC, Qian L, Zhao Y, Mengarelli J, Adrianto I, Montgomery CG, Urban JF Jr, Fung KM, Sun XH. Downregulation of E Protein Activity Augments an ILC2 Differentiation Program in the Thymus. J Immunol. 2017 Apr 15;198(8):3149-56. Epub 2017 Mar 3. PMCID: PMC5404348

Wren JD, Dozmorov MG, Toby I, Nanduri B, Homayouni R, Manda P, Thakkar S. Proceedings of the 2017 MidSouth Computational Biology and Bioinformatics Society (MCBIOS) Conference. BMC Bioinformatics. 2017 Dec 28;18(Suppl 14):498. No abstract available. PMID:29297277

Zhang YM, Zhou XJ, Nath SK, Sun C, Zhao MH, Zhang H. Evaluation of 10 SLE susceptibility loci in Asian populations, which were initially identified in European populations. Sci Rep. 2017 Jan 27;7:41399. PMCID: PMC5269754

Zhao J, Ma J, Deng Y, Kelly JA, Kim K, Bang SY, Lee HS, Li QZ, Wakeland EK, Qiu R, Liu M, Guo J, Li Z, Tan W, Rasmussen A, Lessard CJ, Sivils KL, Hahn BH, Grossman JM, Kamen DL, Gilkeson GS, Bae SC, Gaffney PM, Shen N, Tsao BP. A missense variant in NCF1 is associated with susceptibility to multiple autoimmune diseases. Nat Genet. 2017 Mar;49(3):433-7. Epub 2017 Jan 30. PMID: PMC5400098

Cardiovascular Biology Research Program

Ahamed J, Laurence J. Role of platelet-derived TGF-β1 and ROS in radiation-induced organ fibrosis. Antioxid Redox Signal. 2017 May 31. Epub ahead of print. PMID: 28562065

Cates C, Rousselle T, Wang J, Quan N, Wang L, Chen X, Yang L, Rezaie AR, Li J. Activated protein C protects against pressure overload-induced hypertrophy through AMPK signaling. Biochem Biophys Res Commun. 2017 Dec 26. pii: S0006-291X(17)32525-1. PMID:29287725

Chandrakesan P, Yao J, Qu D, May R, Weygant N, Ge Y, Ali N, Sureban SM, Gude M, Vega K, Bannerman-Menson E, Xia L, Bronze M, An G, Houchen CW. Dclk1, a tumor stem cell marker, regulates pro-survival signaling and self-renewal of intestinal tumor cells. Mol Cancer. 2017 Feb 1;16(1):30. PMCID:PMC5286867

Chen C, Yang L, Villoutreix BO, Wang X, Ding Q, Rezaie AR. Gly74Ser mutation in protein C causes thrombosis due to a defect in protein S-dependent anticoagulant function. Thromb Haemost. 2017 Apr 13. Epub ahead of print. PMID: 28405673

Dinarvand P, Yang L, Villoutreix BO, Rezaie AR. Expression and Functional Characterization of Two Natural Heparin-binding Site Variants of Antithrombin. J Thromb Haemost. 2017 Dec 7. PMID: 29215785

Fuentes-Mattei E, Giza DE, Shimizu M, Ivan C, Manning JT, Tudor S, Ciccone M, Kargin OA, Zhang X, Mur P, do Amaral NS, Chen M, Tarrand JJ, Lupu F, Ferrajoli A, Keating MJ, Vasilescu C, Yeung SJ, Calin GA. Plasma Viral miRNAs Indicate a High Prevalence of Occult Viral Infections. EBioMedicine. 2017 Apr 19. S2352-3964(17) 30162-7. Epub ahead of print. PMID: 28465156

Geng X, Cha B, Mahamud MR, Srinivasan RS. Intraluminal valves: development, function and disease. Dis Model Mech. 2017 Nov 1;10(11):1273-1287. Review. PMID:29125824

Healy LD, Puy C, Fernández JA, Mitrugno A, Keshari RS, Taku NA, Chu TT, Xu X, Gruber A, Lupu F, Griffin JH, McCarty OJ. Activated protein C inhibits neutrophil extracellular trap formation in vitro and activation in vivo. J Biol Chem. 2017 May 26;292(21):8616-29. PMCID: PMC5448091

Keshari RS, Silasi R, Lupu C, Taylor FB Jr, Lupu F. In vivo generated thrombin and plasmin do not activate the complement system in baboons. Blood. 2017 Oct 11. pii: blood-2017-06-788216. PMID:29021229

Keshari RS, Silasi R, Popescu NI, Patel MM, Chaaban H, Lupu C, Coggeshall KM, Mollnes TE, DeMarco SJ, Lupu F. Inhibition of complement C5 protects against organ failure and reduces mortality in a baboon model of Escherichia coli sepsis. Proc Natl Acad Sci U S A. 2017 Jul 18. pii: 201706818. PMID: 28720697

Lee EJ, Dykas DJ, Leavitt AD, …, Rezaie AR, et al. Whole-exome sequencing in evaluation of patients with venous thromboembolism. Blood Adv. 2017 Jun 29;1(16):1224-37. PMCID:PMC5728544

Liu Z, Yago T, Zhang N, Panicker SR, Wang Y, Yao L, Mehta-D’souza P, Xia L, Zhu C, McEver RP. L-selectin mechanochemistry restricts neutrophil priming in vivo. Nat Commun. 2017 May 12;8:15196. PMCID: PMC5437312

Mancini D, Monteagudo J, Suárez-Fariñas M, Bander J, Varshney R, Gonzalez J, Coller BS, Ahamed J. New methodologies to accurately assess circulating active transforming growth factor-β1 levels: implications for evaluating heart failure and the impact of left ventricular assist devices. Transl Res. 2017 Nov 5. pii: S1931-5244(17)30290-6. PMID:29175264

Marsman G, von Richthofen H, Bulder I, Lupu F, Hazelzet J, Luken BM, Zeerleder S. DNA and factor VII-activating protease protect against the cytotoxicity of histones. Blood Adv. 2017 Nov 30;1(26):2491-2502. PMID:29296900

Mehta-D’souza P, Klopocki AG, Oganesyan V, Terzyan S, Mather T, Li Z, Panicker SR, Zhu C, McEver RP. Glycan Bound to the Selectin Low Affinity State Engages Glu-88 to Stabilize the High Affinity State under Force. J Biol Chem. 2017 Feb 10;292(6):2510-18. PMCID: PMC5313117

Menendez MT, Ong EC, Shepherd BT, Muthukumar V, Silasi-Mansat R, Lupu F, Griffin CT. BRG1 (Brahma-Related Gene 1) Promotes Endothelial Mrtf Transcription to Establish Embryonic Capillary Integrity. Arterioscler Thromb Vasc Biol. 2017 Jul 20. pii: ATVBAHA.117.309785. Epub ahead of print. PMID: 28729363

Sarangi PP, Lee HW, Lerman YV, Trzeciak A, Harrower EJ, Rezaie AR, Kim M. Activated Protein C Attenuates Severe Inflammation by Targeting VLA-3^high Neutrophil Subpopulation in Mice. J Immunol. 2017 Oct 15;199(8):2930-6. PMCID:PMC5658029

Song K, Fu J, Song J, Herzog BH, Bergstrom K, Kondo Y, McDaniel JM, McGee S, Silasi-Mansat R, Lupu F, Chen H, Bagavant H, Xia L. Loss of mucin-type O-glycans impairs the integrity of the glomerular filtration barrier in the mouse kidney. J Biol Chem. 2017 Oct 6;292(40):16491-7. PMCID:PMC5633109

Sun C, Berry WL, Olson LE. PDGFRα controls the balance of stromal and adipogenic cells during adipose tissue organogenesis. Development. 2017 Jan 1;144(1):83-94. PMCID: PMC5278626

Yan B, Xu M, Zhao Y, Guo H, Xia L, Ruan C, Zhao Y. Development of a novel flow cytometric immunobead array to quantify VWF:Ag and VWF:GPIbR and its application in acute myocardial infarction. Eur J Haematol. 2017 May 18. Epub ahead of print. PMID: 28523822

Xia L. Platelet CLEC-2: a molecule with 2 faces. Blood. 2017 Nov 16;130(20):2158-2160. PMCID:PMC5691247

Cell Cycle and Cancer Biology Research Program

Alomer RM, da Silva EML, Chen J, Piekarz KM, McDonald K, Sansam CG, Sansam CL, Rankin S. Esco1 and Esco2 regulate distinct cohesin functions during cell cycle progression. Proc Natl Acad Sci USA. 2017 Sep 12;114(37):9906-11. PMCID: PMC5604028

*Fields E, Wren JD, Georgescu C, Daum JR, Gorbsky GJ. Predictive bioinformaticsidentifies novel regulators of proliferation in a cancer stem cell model. StemCell Res. 2017 Nov 21;26:1-7. PMID:29179130

Jordan PW, Eyster C, Chen J, Pezza RJ, Rankin S. Sororin is enriched at the central region of synapsed meiotic chromosomes. Chromosome Res. 2017 Jun;25(2):115-28. PMCID:PMC5441961

de Castro RO, Previato L, Goitea V, Felberg A, Guiraldelli MF, Filiberti A, Pezza RJ. The Chromatin-remodeling Subunit Baf200 Promotes Homology-directed DNA Repair and Regulates Distinct Chromatin-remodeling Complexes. J Biol Chem. 2017 May 19;292(20):8459-71. PMCID:PMC5437250

Jordan PW, Eyster C, Chen J, Pezza RJ, Rankin S. Sororin is enriched at the central region of synapsed meiotic chromosomes. Chromosome Res. 2017 Jun;25(2):115-28. PMCID: PMC5441961

Meyer RE. Back to the Future . . . or . . . Is That All There Is? A Commentary on Courtney et al. J Stud Alcohol Drugs. 2018 Jan;79(1):39-40. PMID: 29227228

Meyer RE, Brown J, Beck L, Dawson DS. Mps1 promotes chromosome meiotic chromosome bi-orientation through Dam1. Mol Biol Cell. 2017 Dec 13. pii: mbc.E17-08-0503. PMID: 29237818

Panicker SR, Mehta-D’souza P, Zhang N, Klopocki AG, Shao B, McEver RP. Circulating soluble P-selectin must dimerize to promote inflammation and coagulation in mice. Blood. 2017 May 17. pii: blood-2017-02-770479. Epub ahead of print. PMID: 28515093

Potapova T, Gorbsky GJ. The Consequences of Chromosome Segregation Errors in Mitosis and Meiosis. Biology (Basel). 2017 Feb 8;6(1). pii: E12. Review. PMCID: PMC5372005

Rao HB, Qiao H, Bhatt SK, Bailey LR, Tran HD, Bourne SL, Qiu W, Deshpande A, Sharma AN, Beebout CJ, Pezza RJ, Hunter N. A SUMO-ubiquitin relay recruits proteasomes to chromosome axes to regulate meiotic recombination. Science. 2017 Jan 27;355(6323):403-7. PMID: 28059716

Sivakumar S, Gorbsky GJ. Phosphatase-regulated recruitment of the spindle- and Kinetochore-Associated (Ska) Complex to kinetochores. Biol Open. 2017 Oct 5. pii: bio.026930. PMCID:PMC5703607

Coagulation Biology Laboratory

Ashar HK, Mueller NC, Rudd JM, Snider TA, Achanta M, Prasanthi M, Pulavendran S, Thomas PG, Akhilesh R, Malayer JR, Ritchey JW, Rajasekhar R, Chow VT, Esmon CT, Teluguakula The role of extracellular histones in influenza virus pathogenesis. N Am J Pathol. 2017 Oct 26. pii: S0002-9440(17). PMID:29107075

Greineder CF, Johnston IH, Villa CH, Gollomp K, Esmon CT, Cines DB, Poncz M, Muzykantov VR. ICAM-1-targeted thrombomodulin mitigates tissue factor-driven inflammatory thrombosis in a human endothelialized microfluidic model. Blood Adv. 2017 Aug 8;1(18):1452-65. PMCID:PMC5727853

Li T, Lee W, Hara H, Long C, Ezzelarab M, Ayares D, Huang H, Wang Y, Esmon CT, Cooper DKC, Iwase H. An Investigation of Extracellular Histones in Pig-To-Baboon Organ Xenotransplantation. Transplantation. 2017 Oct;101(10):2330-9. PMID:28157735

Madhusudhan T, Wang H, Ghosh S, Dong W, Kumar V, Al-Dabet MM, Manoharan J, Nazir S, Elwakiel A, Bock F, Kohli S, Marquardt A, Sögüt I, Shahzad K, Müller AJ, Esmon CT, Nawroth PP, Reiser J, Chavakis T, Ruf W, Isermann B. Signal integration at the PI3K-p85-XBP1 hub endows coagulation protease activated protein C with insulin like function. Blood. 2017 Jul 7. pii: blood-2017-02-767921. PMID: 28687614

McDonald B, Davis RP, Kim SJ, Tse M, Esmon CT, Kolaczkowska E, Jenne CN. Platelets and neutrophil extracellular traps collaborate to promote intravascular coagulation during sepsis in mice. Blood. 2017 Mar 9;129(10):1357-67. PMCID:PMC5345735

Functional & Chemical Genomics Research Program

Yoon WH, Sandoval H, Nagarkar-Jaiswal S, et al. Loss of Nardilysin, a Mitochondrial Co-chaperone for α-Ketoglutarate Dehydrogenase, Promotes mTORC1 Activation and Neurodegeneration. Neuron. 2017 Jan 4;93(1):115-31. PMCID: PMC5242142

Genetic Models of Disease Research Program

Protein Studies

Ghosh AK, Brindisi M, Yen YC, Cárdenas EL, Ella-Menye JR, Kumaragurubaran N, Huang X, Tang J, Mesecar AD. Design, synthesis, and X-ray structural studies of BACE-1 inhibitors containing substituted 2-oxopiperazines as P1′-P2′ ligands. Bioorg Med Chem Lett. 2017 Jun 1;27(11):2432-8. PMID: 28427814

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