2016 Scientific Publications
Advanced Magnetic Resonance Center
Coutinho de Souza P, Mallory S, Smith N, Saunders D, Li XN, McNall-Knapp RY, Fung KM, Towner RA. Inhibition of Pediatric Glioblastoma Tumor Growth by the Anti-Cancer Agent OKN-007 in Orthotopic Mouse Xenografts. PLoS One. 2015 Aug 6;10(8):e0134276. PMCID:PMC4527837
*Dong Y, Wu H, Rahman HN, Liu Y, Pasula S, Tessneer KL, Cai X, Liu X, Chang B, McManus J, Hahn S, Dong J, Brophy ML, Yu L, Song K, Silasi-Mansat R, Saunders D, Njoku C, Song H, Mehta-D’Souza P, Towner R, Lupu F, McEver RP, Xia L, Boerboom D, Srinivasan RS, Chen H. Motif mimetic of epsin perturbs tumor growth and metastasis. J Clin Invest. 2016 Apr 1;126(4):1607. PMCID:PMC4811111
Madka V, Mohammed A, Li Q, Zhang Y, Biddick L, Patlolla JM, Lightfoot S, Towner RA, Wu XR, Steele VE, Kopelovich L, Rao CV. Targeting mTOR and p53 Signaling Inhibits Muscle Invasive Bladder Cancer In Vivo. Cancer Prev Res (Phila). 2016 Jan;9(1):53-62. PMCID:PMC4839263
Mohammadi E, Prusator DK, Healing E, Hurst R, Towner RA, Wisniewski AB, Greenwood-Van Meerveld B. Sexually dimorphic effects of early life stress in rat pups on urinary bladder detrusor muscle contractility in adulthood. Biol Sex Differ. 2016 Jan 27;7:8. PMCID:PMC4730611
Rajagopalan V, Zhang Y, Ojamaa K, Chen YF, Pingitore A, Pol CJ, Saunders D, Balasubramanian K, Towner RA, Gerdes AM. Safe Oral Triiodo-L-Thyronine Therapy Protects from Post-Infarct Cardiac Dysfunction and Arrhythmias without Cardiovascular Adverse Effects. PLoS One. 2016 Mar 16;11(3):e0151413. PMCID:PMC4794221
*Ziegler J, Pody R, Coutinho de Souza P, Evans B, Saunders D, Smith N, Mallory S, Njoku C, Dong Y, Chen H, Dong J, Lerner M, Mian O, Tummala S, Battiste J, Fung KM, Wren JD, Towner RA. ELTD1, an effective anti-angiogenic target for gliomas: preclinical assessment in mouse GL261 and human G55 xenograft glioma models. Neuro Oncol. 2017 Feb 1;19(2):175-85. PMCID:PMC5464087
Aging and Metabolism Research Program
Alund AW, Mercer KE, Suva LJ, Pulliam CF, Chen JR, Badger TM, Van Remmen H, Ronis MJ. Reactive Oxygen Species Differentially Regulate Bone Turnover in an Age-Specific Manner in Catalase Transgenic Female Mice. J Pharmacol Exp Ther. 2016 Jul;358(1):50-60. PMCID:PMC4931876
Berenbaum F, Griffin TM, Liu-Bryan R. Metabolic Regulation of Inflammation in Osteoarthritis. Arthritis Rheumatol. 2017 Jan;69(1):9-21. Review. PMCID:PMC5341385
Crewe C, Schafer C, Lee I, Kinter M, Szweda LI. Regulation of Pyruvate Dehydrogenase Kinase 4 in the Heart Through Degradation by the Lon Protease in Response to Mitochondrial Substrate Availability. J Biol Chem. 2017 Jan 6;292(1):305-12. PMCID:PMC5217688
Deepa SS, Bhaskaran S, Ranjit R, Qaisar R, Nair BC, Liu Y, Walsh ME, Fok WC, Van Remmen H. Down-regulation of the mitochondrial matrix peptidase ClpP in muscle cells causes mitochondrial dysfunction and decreases cell proliferation. Free Radic Biol Med. 2016 Feb;91:281-92. PMID: 26721594
Duan H, Arora D, Li Y, Setiadi H, Xu D, Lim HY, Wang W. Identification of 1,2,3-triazole derivatives that protect pancreatic β cells against endoplasmic reticulum stress-mediated dysfunction and death through the inhibition of C/EBP-homologous protein expression. Bioorg Med Chem. 2016 Jun 15;24(12):2621-30. PMCID:PMC5176337
Evans TM, Bhattacharya A, Shi Y, Qi W, Block TJ, Chaudhuri A, Chaudhuri AR, Hawker K, Van Remmen H. Moderate modulation of disease in the G93A model of ALS by the compound 2-(2-hydroxyphenyl)-benzoxazole (HBX). Neurosci Lett. 2016 Jun 15;624:1-7. Epub 2016 Apr 29. PMID: 27138280
Fu Y, Kinter M, Hudson J, Humphries KM, Lane RS, White JR, Hakim M, Pan Y, Verdin E, Griffin TM. Aging Promotes SIRT3-dependent Cartilage SOD2 Acetylation and Osteoarthritis. Arthritis Rheumatol. 2016 Aug;68(8):1887-98. PMCID:PMC5331855
Griffin TM, Humphries KM, Kinter M, Lim HY, Szweda LI. Nutrient sensing and utilization: Getting to the heart of metabolic flexibility. Biochimie. 2016 May;124:74-83. Review. PMCID:PMC4828282
Griffin TM, Huffman KM. Insulin Resistance: Releasing the Brakes on Synovial Inflammation and Osteoarthritis? Arthritis Rheumatol. 2016 Jun;68(6):1330-3. PMCID:PMC5371020
Gurley JM, Ilkayeva O, Jackson RM, Griesel BA, White P, Matsuzaki S, Qaisar R, Van Remmen H, Humphries KM, Newgard CB, Olson AL. Enhanced GLUT4-Dependent Glucose Transport Relieves Nutrient Stress in Obese Mice Through Changes in Lipid and Amino Acid Metabolism. Diabetes. 2016 Dec;65(12):3585-97. PMCID:PMC5127250
James KL, Ríos-Hernández LA, Wofford NQ, Mouttaki H, Sieber JR, Sheik CS, Nguyen HH, Yang Y, Xie Y, Erde J, Rohlin L, Karr EA, Loo JA, Ogorzalek Loo RR, Hurst GB, Gunsalus RP, Szweda LI, McInerney MJ. Pyrophosphate-Dependent ATP Formation from Acetyl Coenzyme A in Syntrophus aciditrophicus, a New Twist on ATP Formation. MBio. 2016 Aug 16;7(4). pii: e01208-16. PMCID:PMC4992975
June RK, Liu-Bryan R, Long F, Griffin TM. Emerging role of metabolic signaling in synovial joint remodeling and osteoarthritis. J Orthop Res. 2016 Dec;34(12):2048-58. PMCID:PMC5365077
Masser DR, Clark NW, Van Remmen H, Freeman WM. Loss of the antioxidant enzyme CuZnSOD (Sod1) mimics an age-related increase in absolute mitochondrial DNA copy number in the skeletal muscle. Age (Dordr). 2016 Aug;38(4):323-3. PMCID:PMC5061674
Nakada Y, Canseco DC, Thet S, Abdisalaam S, Asaithamby A, Santos CX, Shah A, Zhang H, Faber JE, Kinter MT, Szweda LI, Xing C, Deberardinis R, Oz O, Lu Z, Zhang CC, Kimura W, Sadek HA. Hypoxia induces heart regeneration in adult mice. Nature. 2017 Jan 12;541(7636):222-7. PMID: 27798600
O’Mealey GB, Berry WL, Plafker SM. Sulforaphane is a Nrf2-independent inhibitor of mitochondrial fission. Redox Biol. 2016 Nov 21;11:103-10. PMCID:PMC5126150
Pharaoh G, Pulliam D, Hill S, Sataranatarajan K, Van Remmen H. Ablation of the mitochondrial complex IV assembly protein Surf1 leads to increased expression of the UPR(MT) and increased resistance to oxidative stress in primary cultures of fibroblasts. Redox Biol. 2016 Aug;8:430-8. PMCID:PMC4878459
Qaisar R, Bhaskaran S, Van Remmen H. Muscle fiber type diversification during exercise and regeneration. Free Radic Biol Med. 2016 Sep;98:56-67 PMID: 27032709
Rindler PM, Cacciola A, Kinter M, Szweda LI. Catalase-Dependent H2O2 Consumption by Cardiac Mitochondria and Redox-Mediated Loss in Insulin Signaling. Am J Physiol Heart Circ Physiol. 2016 Nov 1;311(5):H1091-6. PMID: 27614223
Sataranatarajan K, Qaisar R, Davis C, Sakellariou GK, Vasilaki A, Zhang Y, Liu Y, Bhaskaran S, McArdle A, Jackson M, Brooks SV, Richardson A, Van Remmen H. Neuron specific reduction in CuZnSOD is not sufficient to initiate a full sarcopenia phenotype. Redox Biol. 2015 Aug;5:140-8. PMCID:PMC5022075
Zhang Y, Liu Y, Walsh M, Bokov A, Ikeno Y, Jang YC, Perez VI, Van Remmen H, Richardson A. Liver specific expression of Cu/ZnSOD extends the lifespan of Sod1 null mice. Mech Ageing Dev. 2016 Mar;154:1-8. PMCID:PMC4855307
Arthritis and Clinical Immunology Research Program
Bajaña S, Turner S, Paul J, Ainsua-Enrich E, Kovats S. IRF4 and IRF8 Act in CD11c+ Cells To Regulate Terminal Differentiation of Lung Tissue Dendritic Cells. J Immunol. 2016 Feb 15;196(4):1666-77. PMCID:PMC4744567
Bello GA, Brown MA, Kelly JA, Thanou A, James JA, Montgomery CG. Development and validation of a simple lupus severity index using ACR criteria for classification of SLE. Lupus Sci Med. 2016 Mar 10;3(1):e000136. PMCID:PMC4800735
Booth JL, Duggan ES, Patel VI, Langer M, Wu W, Braun A, Coggeshall KM, Metcalf JP. Bacillus anthracis spore movement does not require a carrier cell and is not affected by lethal toxin in human lung models. Microbes Infect. 2016 Oct;18(10):615-26. PMCID:PMC5534360
Brito-Zerón P, Baldini C, Bootsma H, Bowman SJ, Jonsson R, Mariette X, Sivils K, Theander E, Tzioufas A, Ramos-Casals M. Sjögren syndrome. Nat Rev Dis Primers. 2016 Jul 7;2:16047. PMID: 27383445
Brito-Zerón P, Acar-Denizli N, Zeher M, Rasmussen A, …, Sivils K, et al. EULAR-SS Task Force Big Data Consortium. Influence of geolocation and ethnicity on the phenotypic expression of primary Sjögren’s syndrome at diagnosis in 8310 patients: a cross-sectional study from the Big Data Sjögren Project Consortium. Ann Rheum Dis. 2017 Jun;76(6):1042-50. PMID: 27899373
Carsons SE, Vivino FB, Parke A, …, Scofield H, Hammitt KM, Birnbaum J, Kassan S, Mandel S. Treatment Guidelines for Rheumatologic Manifestations of Sjögren’s: Use of Biologics, Management of Fatigue and Inflammatory Musculoskeletal Pain. Arthritis Care Res (Hoboken). 2017 Apr;69(4):517-27. PMID: 27390247
Chakravarty EF. Incidence and Prevention of Herpes Zoster Reactivation in Patients with Autoimmune Diseases. Rheum Dis Clin North Am. 2017 Feb;43(1):111-121. Review. PMID: 27890168
Deng Y, Zhao J, Sakurai D, Sestak AL, Osadchiy V, Langefeld CD, Kaufman KM, Kelly JA, James JA, Petri MA, Bae SC, Alarcón-Riquelme ME, Alarcón GS, Anaya JM, Criswell LA, Freedman BI, Kamen DL, Gilkeson GS, Jacob CO, Merrill JT, Gaffney PM, Sivils KM, Niewold TB, Ramsey-Goldman R, Reveille JD, Scofield RH, Stevens AM, Boackle SA, Vilá LM, Sohn II, Lee S, Chang DM, Song YW, Vyse TJ, Harley JB, Brown EE, Edberg JC, Kimberly RP, Cantor RM, Hahn BH, Grossman JM, Tsao BP. Decreased SMG7 expression associates with lupus-risk variants and elevated antinuclear antibody production. Ann Rheum Dis. 2016 Nov;75(11):2007-13. PMCID:PMC4949149
Dozmorov MG, Cara LR, Giles CB, Wren JD. GenomeRunner web server: regulatory similarity and differences define the functional impact of SNP sets. Bioinformatics. 2016 Aug 1;32(15):2256-63. PMCID:PMC4965636
Fayyaz A, Kurien BT, Scofield RH. Autoantibodies in Sjögren’s Syndrome. Rheum Dis Clin North Am. 2016 Aug;42(3):419-34. Review. PMCID:PMC4955792
Fedorowski A, Li H, Yu X, Koelsch KA, Harris VM, Liles C, Murphy TA, Quadri SM, Scofield RH, Sutton R, Melander O, Kem DC. Antiadrenergic autoimmunity in postural tachycardia syndrome. Europace. 2016 Oct 4. pii: euw154. PMID:27702852
Fuchs T, Kelly JA, Simon E, Sivils KL, Hermel E. The anti-inflammatory CASPASE-12 gene does not influence SLE phenotype in African-Americans. Immunol Lett. 2016 May;173:21-5. PMID: 26973091
Garman L, Smith K, Muns EE, Velte CA, Spooner CE, Munroe ME, Farris AD, Nelson MR, Engler RJ, James JA. Unique Inflammatory Mediators and Specific IgE Levels Distinguish Local from Systemic Reactions After AVA Vaccination. Clin Vaccine Immunol. 016 Aug 5;23(8):664-71. PMCID:PMC4979178
Gerosa M, Poletti B, Pregnolato F, Castellino G, Lafronza A, Silani V, Riboldi P, Meroni PL, Merrill JT. Antiglutamate Receptor Antibodies and Cognitive Impairment in Primary Antiphospholipid Syndrome and Systemic Lupus Erythematosus. Front Immunol. 2016 Feb 1;7:5. Review. PMCID:PMC4740786
Hadad N, Masser DR, Logan S, Wronowski B, Mangold CA, Clark N, Otalora L, Unnikrishnan A, Ford MM, Giles CB, Wren JD, Richardson A, Sonntag WE, Stanford DR, Freeman W. Absence of genomic hypomethylation or regulation of cytosine-modifying enzymes with aging in male and female mice. Epigenetics Chromatin. 2016 Jul 13;9:30. PMCID:PMC4942942
Handley N, Eide J, Taylor R, Wuertz B, Gaffney P, Ondrey F. PPARγ targeted oral cancer treatment and additional utility of genomics analytic techniques. Laryngoscope. 2017 Apr;127(4):E124-31. PMCID:PMC5360511
Hanly JG, Su L, Urowitz MB, Romero-Diaz J, Gordon C, Bae SC, Bernatsky S, Clarke AE, Wallace DJ, Merrill JT, Isenberg DA, Rahman A, Ginzler EM, Petri M, Bruce IN, Dooley MA, Fortin P, Gladman DD, Sanchez-Guerrero J, Steinsson K, Ramsey-Goldman R, Khamashta MA, Aranow C, Alarcón GS, Fessler BJ, Manzi S, Nived O, Sturfelt GK, Zoma AA, van Vollenhoven RF, Ramos-Casals M, Ruiz-Irastorza G, Sam Lim S, Kalunian KC, Inanc M, Kamen DL, Peschken CA, Jacobsen S, Askanase A, Theriault C, Farewell V. A Longitudinal Analysis of Outcomes of Lupus Nephritis in an International Inception Cohort Using a Multistate Model Approach. Arthritis Rheumatol. 2016 Aug;68(8):1932-44. PMID: 26991067
Hoffman RW, Merrill JT, Alarcón-Riquelme MM, Petri M, Dow ER, Nantz E, Nisenbaum LK, Schroeder KM, Komocsar WJ, Perumal NB, Linnik MD, Airey DC, Liu Y, Rocha GV, Higgs RE. Gene Expression and Pharmacodynamic-Induced Changes in 1,760 SLE Patients from Two Phase III Trials of B Cell Activating Factor Blockade with Tabalumab. Arthritis Rheumatol. 2016 Aug;68(8):1932-44. PMID: 27723281
Isenberg DA, Merrill JT. Why, why, why de-lupus (does so badly in clinical trials). Expert Rev Clin Immunol. 2016;12(2):95-8. PMID: 26786849
Joachims ML, Leehan KM, Lawrence C, Pelikan RC, Moore JS, Pan Z, Rasmussen A, Radfar L, Lewis DM, Grundahl KM, Kelly JA, Wiley GB, Shugay M, Chudakov DM, Lessard CJ, Stone DU, Scofield RH, Montgomery CG, Sivils KL, Thompson LF, Farris AD. Single-cell analysis of glandular T cell receptors in Sjögren’s syndrome. JCI Insight. 2016 Jun 2;1(8). pii: e85609. PMCID:PMC4922426
Kalunian KC, Kim M, Xie X, Baskaran A, Daly RP, Merrill JT. Impact of standard of care treatments and disease variables on outcomes in systemic lupus erythematosus trials: analysis from the Lupus Foundation of America Collective Data Analysis Initiative. Eur J Rheumatol. 2016 Mar;3(1):13-9. PMCID:PMC5042268
Kim K, Bang SY, Yoo DH, Cho SK, Choi CB, Sung YK, Kim TH, Jun JB, Kang YM, Suh CH, Shim SC, Lee SS, Lee J, Chung WT, Kim SK, Choe JY, Nath SK, Lee HS, Bae SC. Imputing Variants in HLA-DR Beta Genes Reveals That HLA-DRB1 Is Solely Associated with Rheumatoid Arthritis and Systemic Lupus Erythematosus. PLoS One. 2016 Feb 26;11(2):e0150283. PMCID:PMC4769216
Kim MY, Buyon JP, Guerra MM, Rana S, Zhang D, Laskin CA, Petri M, Lockshin MD, Sammaritano LR, Branch DW, Porter TF, Merrill JT, Stephenson MD, Gao Q, Karumanchi SA, Salmon JE. Angiogenic factor imbalance early in pregnancy predicts adverse outcomes in patients with lupus and antiphospholipid antibodies: results of the PROMISSE study. Am J Obstet Gynecol. 2016 Jan;214(1):108.e1-108.e14. PMCID:PMC4698098
Kim TD, Jin F, Shin S, Oh S, Lightfoot SA, Grande JP, Johnson AJ, van Deursen JM, Wren JD, Janknecht R. Histone demethylase JMJD2A drives prostate tumorigenesis through transcription factor ETV1. J Clin Invest. 2016 Feb;126(2):706-20. PMCID:PMC4731184
Kovats S, Turner S, Simmons A, Powe T, Chakravarty E, Alberola-Ila J. West Nile Virus Infected Human Dendritic Cells Fail to Fully Activate Invariant Natural Killer T cells. Clin Exp Immunol. 2016 Nov;186(2):214-26. PMCID:PMC5054575
Kurien BT, Fesmire J, Anderson CJ, Scofield RH. Anti-Ro and Concomitant Anti-La Autoantibodies Strongly Associated With Anti-oxLDL or Anti-Phospholipid Antibody in Systemic Lupus Erythematosus. J Clin Rheumatol. 2016 Dec;22(8):418-25. PMID: 27870764
Kushwaha G, Dozmorov M, Wren JD, Qiu J, Shi H, Xu D. Hypomethylation coordinates antagonistically with hypermethylation in cancer development: a case study of leukemia. Hum Genomics. 2016 Jul 25;10 Suppl 2:18. PMCID:PMC4965721
Li G, Bankhead P, Dunne PD, O’Reilly PG, James JA, Salto-Tellez M, Hamilton PW, McArt DG. Embracing an integromic approach to tissue biomarker research in cancer: Perspectives and lessons learned. Brief Bioinform. 2016 Jun 2. pii: bbw044. PMID: 27255914
Liu K, Kurien BT, Zimmerman SL,…, Guthridge JM, James JA, Lessard CJ, Kelly JA, Thompson SD, Gaffney PM,…, Merrill JT,…, Sivils KL, Harley JB, Scofield RH. X Chromosome Dose and Sex Bias in Autoimmune Diseases: Increased Prevalence of 47,XXX in Systemic Lupus Erythematosus and Sjögren’s Syndrome. Arthritis Rheumatol. 2016 May;68(5):1290-1300. PMCID:PMC5019501
Lu R, Munroe ME, Guthridge JM, Bean KM, Fife DA, Chen H, Slight-Webb SR, Keith MP, Harley JB, James JA. Dysregulation of innate and adaptive serum mediators precedes systemic lupus erythematosus classification and improves prognostic accuracy of autoantibodies. J Autoimmun. 2016 Nov;74:182-193. PMCID:PMC5079766
Mangold CA, Masser DR, Stanford DR, Bixler GV, Pisupati A, Giles CB, Wren JD, Ford MM, Sonntag WE, Freeman WM. CNS-wide Sexually Dimorphic Induction of the Major Histocompatibility Complex 1 Pathway With Aging. J Gerontol A Biol Sci Med Sci. 2017 Jan;72(1):16-29. PMCID:PMC5155655
Masser DR, Stanford DR, Hadad N, Giles CB, Wren JD, Sonntag WE, Richardson A, Freeman WM. Bisulfite oligonucleotide-capture sequencing for targeted base- and strand-specific absolute 5-methylcytosine quantitation. Age (Dordr). 2016 Jun;38(3):49. PMCID:PMC5005917
Mishra A, Nizammuddin S, Basu Mallick C, Singh S, Prakash S, Siddiqui NA, Rai N, Carlus SJ, Sudhakar DV, Tripathi VP, Möls M, Kim-Howard X, Dewangan H, Mishra A, Reddy AG, Roy B, Pandey K, Chaubey G, Das P, Nath SK, Singh L, Thangaraj K. Genotype-phenotype study of Middle Gangetic Plain in India reveals association of rs2470102 with skin pigmentation. J Invest Dermatol. 2017 Mar;137(3):670-677. PMID: 27866970
Morris DL, Sheng Y, Zhang Y, …, Gaffney PM, Lau YL, Zhang X, Yang W, Cui Y, Vyse TJ. Genome-wide association meta-analysis in Chinese and European individuals identifies ten new loci associated with systemic lupus erythematosus. Nat Genet. 2016 Aug;48(8):940-6. PMCID:PMC4966635
Munroe ME, Lu R, Zhao YD, Fife DA, Robertson JM, Guthridge JM, Niewold TB, Tsokos GC, Keith MP, Harley JB, James JA. Altered type II interferon precedes autoantibody accrual and elevated type I interferon activity prior to systemic lupus erythematosus classification. Ann Rheum Dis. 2016 Nov;75(11):2014-21. PMCID:PMC4959992
Munroe ME, Young KA, Kamen DL, Guthridge JM, Niewold TB, Costenbader KH, Weisman MH, Ishimori ML, Wallace DJ, Gilkeson GS, Karp DR, Harley JB, Norris JM, James JA. Soluble Mediators and Clinical Features Discern Risk of Transitioning to Classified Disease in Relatives of Systemic Lupus Erythematosus Patients. Arthritis Rheumatol. 2017 Mar;69(3):630-42. PMCID:PMC5329053
Pan ZJ, Horton CG, Lawrence C, Farris AD. Plasmacytoid dendritic cells and type 1 IFN promote peripheral expansion of Foxp3(+) regulatory T cells specific for the ubiquitous RNA-binding nuclear antigen La/SS-B. Clin Exp Immunol. 2016 Oct;186(1):18-29. PMCID:PMC5011359
Raj P, Rai E, Song R, Khan S, Wakeland BE, Viswanathan K, Arana C, Liang C, Zhang B, Dozmorov I, Carr-Johnson F, Mitrovic M, Wiley GB, Kelly JA, Lauwerys BR, Olsen NJ, Cotsapas C, Garcia CK, Wise CA, Harley JB, Nath SK, James JA, Jacob CO, Tsao BP, Pasare C, Karp DR, Li QZ, Gaffney PM, Wakeland EK. Regulatory polymorphisms modulate the expression of HLA class II molecules and promote autoimmunity. Elife. 2016 Feb 16;5. pii: e12089. PMCID:PMC4811771
Rasmussen A, Radfar L, Lewis D, Grundahl K, Stone DU, Kaufman CE, Rhodus NL, Segal B, Wallace DJ, Weisman MH, Venuturupalli S, Kurien BT, Lessard CJ, Sivils KL, Scofield RH. Previous diagnosis of Sjögren’s Syndrome as rheumatoid arthritis or systemic lupus erythematosus. Rheumatology (Oxford). 2016 Jul;55(7):1195-201. PMID: 26998859
Ratliff ML, Mishra M, Frank MB, Guthridge JM, Webb CF. The Transcription Factor ARID3a Is Important for In Vitro Differentiation of Human Hematopoietic Progenitors. J Immunol. 2016 Jan 15;196(2):614-23. PMCID:PMC4858324
Reksten TR, Lessard CJ, Sivils KL. Genetics in Sjögren Syndrome. Rheum Dis Clin North Am. 2016 Aug;42(3):435-47. Review. PMID: 27431346
Salmon AB, Kim G, Liu C, Wren JD, Georgescu C, Richardson A, Levine RL. Effects of transgenic methionine sulfoxide reductase A (MsrA) expression on lifespan and age-dependent changes in metabolic function in mice. Redox Biol. 2016 Dec;10:251-6. PMCID:PMC5099276
Sandhya P, Kurien BT, Danda D, Scofield RH. Update on Pathogenesis of Sjögren’s syndrome. Curr Rheumatol Rev. 2016 Jul 14. PMCID:PMC5280579
Scofield RH. Sjögren Syndrome in the Twenty-First Century. Rheum Dis Clin North Am. 2016 Aug;42(3):xiii-xiv. PMID: 27431355
Shapiro VS, Kovats S, Parent MA, Gaffen SL, Hedrick CC, Jain P, Denzin LK, Raghavan M, Stephens R. Update on Gender Equity in Immunology, 2001 to 2016. J Immunol. 2016 Nov 15;197(10):3751-3. PMID: 27798172
Shiboski CH, Shiboski SC, Seror R, Criswell LA, Labetoulle M, Lietman TM, Rasmussen A, Scofield H, Vitali C, Bowman SJ, Mariette X; International Sjögren’s Syndrome Criteria Working Group.. 2016 American College of Rheumatology/European League Against Rheumatism Classification Criteria for Primary Sjögren’s Syndrome: A Consensus and Data-Driven Methodology Involving Three International Patient Cohorts. Arthritis Rheumatol. 2017 Jan;69(1):35-45. PMID: 27785888
Smith S, Elliot AJ, Hajat S, Bone A, Bates C, Smith GE, Kovats S. The Impact of Heatwaves on Community Morbidity and Healthcare Usage: A Retrospective Observational Study Using Real-Time Syndromic Surveillance. Int J Environ Res Public Health. 2016 Jan 16;13(1). pii: E132. PMCID:PMC4730523
Stock AJ, Kasus-Jacobi A, Wren JD, Sjoelund VH, Prestwich GD, Pereira HA. The Role of Neutrophil Proteins on the Amyloid Beta-RAGE Axis. PLoS One. 2016 Sep 27;11(9):e0163330. PMCID:PMC5038948
Sun C, Molineros JE, Looger LL, Zhou XJ, Kim K, Okada Y, Ma J, Qi YY, Kim-Howard X, Motghare P, Bhattarai K, Adler A, Bang SY, Lee HS, Kim TH, Kang YM, Suh CH, Chung WT, Park YB, Choe JY, Shim SC, Kochi Y, Suzuki A, Kubo M, Sumida T, Yamamoto K, Lee SS, Kim YJ, Han BG, Dozmorov M, Kaufman KM, Wren JD, Harley JB, Shen N, Chua KH, Zhang H, Bae SC, Nath SK. High-density genotyping of immune-related loci identifies new SLE risk variants in individuals with Asian ancestry. Nat Genet. 2016 Mar;48(3):323-30. PMCID:PMC4767573
Tarantini S, Giles CB, Wren JD, Ashpole NM, Valcarcel-Ares MN, Wei JY, Sonntag WE, Ungvari Z, Csiszar A. IGF-1 deficiency in a critical period early in life influences the vascular aging phenotype in mice by altering miRNA-mediated post-transcriptional gene regulation: implications for the developmental origins of health and disease hypothesis. Age (Dordr). 2016 Aug 26. 2016 Aug;38(4):239-58. PMCID:PMC5061677
Tarantini S, Tucsek Z, Valcarcel-Ares MN, Toth P, Gautam T, Giles CB, Ballabh P, Wei JY, Wren JD, Ashpole NM, Sonntag WE, Ungvari Z, Csiszar A. Circulating IGF-1 deficiency exacerbates hypertension-induced microvascular rarefaction in the mouse hippocampus and retrosplenial cortex: implications for cerebromicrovascular and brain aging. Age (Dordr). 2016 Aug;38(4):273-89. PMCID:PMC5061685
Thanou A, Stavrakis S, Dyer JW, Munroe ME, James JA, Merrill JT. Impact of heart rate variability, a marker for cardiac health, on lupus disease activity. Arthritis Res Ther. 2016 Sep 2;18(1):197. PMCID:PMC5010705
Tsou PS, Wren JD, Amin MA, Schiopu E, Fox DA, Khanna D, Sawalha AH. Histone Deacetylase 5 is Overexpressed in Scleroderma Endothelial Cells and Impairs Angiogenesis via Repressing Pro-angiogenic Factors. Arthritis Rheumatol. 2016 Dec;68(12):2975-85. PMCID: PMC5125850
Urowitz MB, Gladman DD, Anderson NM, Su J, Romero-Diaz J, Bae SC, Fortin PR, Sanchez-Guerrero J, Clarke A, Bernatsky S, Gordon C, Hanly JG, Wallace DJ, Isenberg D, Rahman A, Merrill J, Ginzler E, Alarcón GS, Fessler BF, Petri M, Bruce IN, Khamashta M, Aranow C, Dooley M, Manzi S, Ramsey-Goldman R, Sturfelt G, Nived O, Steinsson K, Zoma A, Ruiz-Irastorza G, Lim S, Kalunian KC, Ỉnanç M, van Vollenhoven R, Ramos-Casals M, Kamen DL, Jacobsen S, Peschken C, Askanase A, Stoll T. Cardiovascular events prior to or early after diagnosis of systemic lupus erythematosus in the systemic lupus international collaborating clinics cohort. Lupus Sci Med. 2016 Apr 12;3(1):e000143. PMCID:PMC4836282
Vivino FB, Carsons SE, Foulks G, Daniels TE, Parke A, Brennan MT, Forstot SL, Scofield RH, Hammitt KM. New Treatment Guidelines for Sjögren’s Disease. Rheum Dis Clin North Am. 2016 Aug;42(3):531-51. Review. PMID: 27431353
Wallace DJ, Strand V, Merrill JT, et al. Efficacy and safety of an interleukin 6 monoclonal antibody for the treatment of systemic lupus erythematosus: a phase II dose-ranging randomised controlled trial. Ann Rheum Dis. 2017 Mar;76(3):534-42. PMCID:PMC5446001
Wang S, Wen F, Tessneer KL, Gaffney PM. TALEN-mediated enhancer knockout influences TNFAIP3 gene expression and mimics a molecular phenotype associated with systemic lupus erythematosus. Genes Immun. 2016 Apr;17(3):165-70. PMCID:PMC4840072
Ward JM, Ratliff ML, Dozmorov MG, Wiley G, Guthridge JM, Gaffney PM, James JA, Webb CF. Human effector B lymphocytes express ARID3a and secrete interferon alpha. J Autoimmun. 2016 Dec;75:130-40. PMCID:PMC5134920
Ward JM, Ratliff ML, Dozmorov MG, Wiley G, Guthridge JM, Gaffney PM, James JA, Webb CF. Expression and methylation data from SLE patient and healthy control blood samples subdivided with respect to ARID3a levels. Data Brief. 2016 Aug 31;9:213-9. PMCID:PMC5021782
Wirsdörfer F, de Leve S, Cappuccini F, Eldh T, Meyer AV, Gau E, Thompson LF, Chen NY, Karmouty-Quintana H, Fischer U, Kasper M, Klein D, Ritchey JW, Blackburn MR, Westendorf AM, Stuschke M, Jendrossek V. Extracellular adenosine production by ecto-5′-nucleotidase (CD73) enhances radiation-induced lung fibrosis. Cancer Res. 2016 May 15;76(10):3045-56. PMCID:PMC4960984
Wolf AJ, Reyes CN, Liang W, Becker C, Shimada K, Wheeler ML, Cho HC, Popescu NI, Coggeshall KM, Arditi M, Underhill DM. Hexokinase Is an Innate Immune Receptor for the Detection of Bacterial Peptidoglycan. Cell. 2016 Jul 28;166(3):624-36. PMCID:PMC5534359
Wren JD. Bioinformatics programs are 31-fold over-represented among the highest impact scientific papers of the past two decades. Bioinformatics. 2016 Sep 1;32(17):2686-91. PMID: 27153671
Wren JD. Clinical trial IDs need to be validated prior to publication because hundreds of invalid National Clinical Trial Identifications are regularly entering MEDLINE. Clin Trials. 2017 Feb;14(1):109. PMID: 27625315
Wren JD, Toby I, Hong H, Nanduri B, Kaundal R, Dozmorov MG, Thakkar S. Proceedings of the 2016 MidSouth Computational Biology and Bioinformatics Society (MCBIOS) Conference. BMC Bioinformatics. 2016 Oct 6;17(Suppl 13):356. PMCID:PMC5073803
Wright SK, Wuertz BR, Harris G, Abu Ghazallah R, Miller WA, Gaffney PM, Ondrey FG. Functional activation of PPARγ in human upper aerodigestive cancer cell lines. Mol Carcinog. 2017 Jan;56(1):149-62. PMID: 26999671
Wu YY, Kumar R, Iida R, Bagavant H, Alarcón-Riquelme ME. BANK1 Regulates IgG Production in a Lupus Model by Controlling TLR7-Dependent STAT1 Activation. PLoS One. 2016 May 26;11(5):e0156302. PMCID:PMC4882053
Yelnik CM, Laskin CA, Porter TF, Branch DW, Buyon JP, Guerra MM, Lockshin MD, Petri M, Merrill JT, Sammaritano LR, Kim MY, Salmon JE. Lupus anticoagulant is the main predictor of adverse pregnancy outcomes in aPL-positive patients: validation of PROMISSE study results. Lupus Sci Med. 2016 Jan 12;3(1):e000131. PMCID:PMC4716418
Yelnik CM, Porter TF, Branch DW, Laskin CA, Merrill JT, Guerra MM, Lockshin MD, Buyon JP, Petri M, Sammaritano LR, Stephenson MD, Kim MY, Salmon JE. Changes in Antiphospholipid Antibody Titers during Pregnancy: Data from the PROMISSE Study. Arthritis Rheumatol. 2016 Aug;68(8):1964-9. PMCID:PMC5380363
Young KA, Munroe ME, Guthridge JM, Kamen DL, Niewold TB, Gilkeson GS, Weisman MH, Ishimori ML, Kelly J, Gaffney PM, Sivils KH, Lu R, Wallace DJ, Karp DR, Harley JB, James JA, Norris JM. Combined role of vitamin D status and CYP24A1 in the transition to systemic lupus erythematosus. Ann Rheum Dis. 2017 Jan;76(1):153-8. PMCID:PMC5360632
*Ziegler J, Pody R, Coutinho de Souza P, Evans B, Saunders D, Smith N, Mallory S, Njoku C, Dong Y, Chen H, Dong J, Lerner M, Mian O, Tummala S, Battiste J, Fung KM, Wren JD, Towner RA. ELTD1, an effective anti-angiogenic target for gliomas: preclinical assessment in mouse GL261 and human G55 xenograft glioma models. Neuro Oncol. 2017 Feb 1;19(2):175-85. PMCID:PMC5464087
Zhou XJ, Nath SK, Qi YY, Sun C, Hou P, Zhang YM, Lv JC, Shi SF, Liu LJ, Chen R, Yang W, He KZ, Li Y, Zhang H. Novel identified associations of RGS1 and RASGRP1 variants in IgA Nephropathy. Sci Rep. 2016 Nov 2;6:35781. PMCID:PMC5090199
Zhang Y, Unnikrishnan A, Deepa SS, Liu Y, Li Y, Ikeno Y, Sosnowska D, Van Remmen H, Richardson A. A new role for oxidative stress in aging: The accelerated aging phenotype in Sod1(-/)(-) mice is correlated to increased cellular senescence. Redox Biol. 2016 Nov 2;11:30-7. PMCID:PMC5109248
Cardiovascular Biology Research Program
Ahamed J, Terry H, Choi ME, Laurence J. Transforming growth factor-β1-mediated cardiac fibrosis: potential role in HIV and HIV/antiretroviral therapy-linked cardiovascular disease. AIDS. 2016 Feb 20;30(4):535-42. [Abstract] PMCID: PMC4738098
Bergstrom K, Fu J, Johansson ME, Liu X, Gao N, Wu Q, Song J, McDaniel JM, McGee S, Chen W, Braun J, Hansson GC, Xia L. Core 1- and 3-derived O-glycans collectively maintain the colonic mucus barrier and protect against spontaneous colitis in mice. Mucosal Immunol. 2016 May 4. [Epub ahead of print] [Abstract] PMID: 27143302
Cha B, Geng X, Mahamud MR, Fu J, Mukherjee A, Kim Y, Jho EH, Kim TH, Kahn ML, Xia L, Dixon JB, Chen H, Srinivasan RS. Mechanotransduction activates canonical Wnt/β-catenin signaling to promote lymphatic vascular patterning and the development of lymphatic and lymphovenous valves. Genes Dev. 2016 Jun 16. [Epub ahead of print] [Abstract] PMID: 27313318
Cha B, Srinivasan RS. Mechanosensitive β-catenin signaling regulates lymphatic vascular development. BMB Rep. 2016 Aug;49(8):403-4. [Abstract]PMCID: PMC5070726
Chen WS, Cao Z, Sugaya S, Lopez MJ, Sendra VG, Laver N, Leffler H, Nilsson UJ, Fu J, Song J, Xia L, Hamrah P, Panjwani N. Pathological lymphangiogenesis is modulated by galectin-8-dependent crosstalk between podoplanin and integrin-associated VEGFR-3. Nat Commun. 2016 Apr 12;7:11302. [Abstract] PMID: 27066737
Crosswhite PL, Podsiadlowska JJ, Curtis CD, Gao S, Xia L, Srinivasan RS, Griffin CT. CHD4-regulated plasmin activation impacts lymphovenous hemostasis and hepatic vascular integrity. J Clin Invest. 2016 Jun 1;126(6):2254-66. Epub 2016 May 3. [Abstract] PMCID: PMC4887170
*Dong Y, Wu H, Rahman HN, Liu Y, Pasula S, Tessneer KL, Cai X, Liu X, Chang B, McManus J, Hahn S, Dong J, Brophy ML, Yu L, Song K, Silasi-Mansat R, Saunders D, Njoku C, Song H, Mehta-D’Souza P, Towner R, Lupu F, McEver RP, Xia L, Boerboom D, Srinivasan RS, Chen H. Motif mimetic of epsin perturbs tumor growth and metastasis. J Clin Invest. 2016 Mar 21. pii: 87344. [Abstract] [Epub ahead of print] PMID: 26999611
Frej C, Linder A, Happonen KE, Taylor FB, Lupu F, Dahlbäck B. Sphingosine 1-phosphate and its carrier apolipoprotein M in human sepsis and in Escherichia coli sepsis in baboons. J Cell Mol Med. 2016 Mar 17. [Abstract] [Epub ahead of print] PMID: 26990127
Fu J, Xia L. CLEC-2 and podoplanin, partners again. Blood. 2016 Mar 31;127(13):1629-30. [Abstract] PMCID: PMC4817307
Gao N, Bergstrom K, Fu J, Xie B, Chen W, Xia L. Loss of intestinal O-glycans promotes spontaneous duodenal tumors. Am J Physiol Gastrointest Liver Physiol. 2016 May 26:ajpgi.00060.2016. [Epub ahead of print] [Abstract] PMID: 27229122
Geng X, Cha B, Mahamud MR, Lim KC, Silasi-Mansat R, Uddin MK, Miura N, Xia L, Simon AM, Engel JD, Chen H, Lupu F, Srinivasan RS. Multiple mouse models of primary lymphedema exhibit distinct defects in lymphovenous valve development. Dev Biol. 2016 Jan 1;409(1):218-33. Epub 2015 Nov 2. [Abstract] PMCID: PMC4688075
Giza DE, Fuentes-Mattei E, Bullock MD, Tudor S, Goblirsch MJ, Fabbri M, Lupu F, Yeung SJ, Vasilescu C, Calin GA. Cellular and viral microRNAs in sepsis: mechanisms of action and clinical applications. Cell Death Differ. 2016 Oct 14. [Epub ahead of print] Review. [Abstract] PMID: 27740627
He X, Cheng R, Park K, Benyajati S, Moiseyev G, Sun C, Olson LE, Yang Y, Eby BK, Lau K, Ma JX. Pigment epithelium-derived factor, a noninhibitory serine protease inhibitor, is renoprotective by inhibiting the Wnt pathway. Kidney Int. 2016 Nov 30. pii: S0085-2538(16)30588-9. [Epub ahead of print] [Abstract] PMID: 27914705
Kumar P, Kuhlmann FM, Bhullar K, Yang H, Vallance BA, Xia L, Luo Q, Fleckenstein JM. Dynamic interactions of a conserved enterotoxigenic Escherichia coli adhesin with intestinal mucins govern epithelial engagement and toxin delivery. Infect Immun. 2016 Oct 10. pii: IAI.00692-16. [Epub ahead of print] [Abstract] PMID: 27736776
Liu Z, Zhang N, Shao B, Panicker SR, Fu J, McEver RP. Replacing the Promoter of the Murine Gene Encoding P-selectin with the Human Promoter Confers Human-like Basal and Inducible Expression in Mice. J Biol Chem. 2016 Jan 15;291(3):1441-7. [Abstract] PMCID: PMC4714226
McEver RP. Dampening neutrophil integrins. Blood. 2016 Jul 28;128(4):467-8. PMCID:PMC4965902
Munger SJ, Geng X, Srinivasan RS, Witte MH, Paul DL, Simon AM. Segregated Foxc2, NFATc1 and Connexin expression at normal developing venous valves, and connexin-specific differences in the valve phenotypes of Cx37, Cx43, and Cx47 knockout mice. Dev Biol. 2016 Mar 4. pii: S0012-1606(15)30258-X. [Abstract] [Epub ahead of print] PMID: 26953188
Pan J, Dinh TT, Rajaraman A, Lee M, Scholz A, Czupalla CJ, Kiefel H, Zhu L, Xia L, Morser J, Jiang H, Santambrogio L, Butcher EC. Patterns of expression of factor VIII and von Willebrand factor by endothelial cell subsets in vivo. Blood. 2016 May 12. pii: blood-2015-12-684688. [Epub ahead of print] [Abstract] PMID: 27207787
Rahman HA, Wu H, Dong Y, Pasula S, Wen A, Sun Y, Brophy ML, Tessneer KL, Cai X, McManus J, Chang B, Kwak S, Rahman NS, Xu W, Fernandes C, Mcdaniel JM, Xia L, Smith L, Srinivasan RS, Chen H. Selective Targeting of a Novel Epsin-VEGFR2 Interaction Promotes VEGF-Mediated Angiogenesis. Circ Res. 2016 Feb 15. pii: CIRCRESAHA.115.307679. [Epub ahead of print] [Abstract] PMID: 26879230
Zhang N, Liu Z, Yao L, Mehta-D’souza P, McEver RP. P-Selectin Expressed by a Human SELP Transgene Is Atherogenic in Apolipoprotein E-Deficient Mice. Arterioscler Thromb Vasc Biol. 2016 Apr 21. pii: ATVBAHA.116.307437. [Epub ahead of print] [Abstract] PMCID:PMC4882243
Cell Cycle and Cancer Biology Research Program
Kurdzo EL, Obeso D, Chuong H, Dawson DS. Meiotic Centromere Coupling and Pairing Function by Two Separate Mechanisms in Saccharomyces cerevisiae. Genetics. 2016 Dec 2. pii: genetics.116.190264. [Epub ahead of print] [Abstract] PMID: 27913618
Rankin S, Dawson DS. Recent advances in cohesin biology. F1000Res. 2016 Aug 3;5. pii: F1000 Faculty Rev-1909. eCollection 2016. Review. [Abstract] PMCID:PMC4975370
Sivakumar S, Janczyk PŁ, Qu Q, Brautigam CA, Stukenberg PT, Yu H, Gorbsky GJ. The human SKA complex drives the metaphase-anaphase cell cycle transition by recruiting protein phosphatase 1 to kinetochores. Elife. 2016 Mar 16;5. pii: e12902. [Abstract] PMCID: PMC4821802
Coagulation Biology Laboratory
Gur-Cohen SG, Itkin T, Chakrabarty S, Graf C, Kollet O, Ludin A, Golan K, Kalinkovich A, Ledergor G, Wong E, Niemeyer E, Porat Z, Erez A, Sagi I, Esmon CT, Ruf W, Lapidot T. PAR1 signaling regulates the retention and recruitment of EPCR-expressing bone marrow hematopoietic stem cells. Nat Med. 2015 Nov;21(11):1307-17. Epub 2015 Oct 12. [Abstract] PMCID:PMC4776769
Gur-Cohen S, Kollet O, Graf C, Esmon CT, Ruf W, Lapidot T. Regulation of long-term repopulating hematopoietic stem cells by EPCR/PAR1 signaling. Ann N Y Acad Sci. 2016 Apr;1370(1):65-81. Epub 2016 Mar 1. [Abstract] PMID: 26928241
Gur-Cohen S, Itkin T, Chakrabarty S, Graf C, Kollet O, Ludin A, Golan K, Kalinkovich A, Ledergor G, Wong E, Niemeyer E, Porat Z, Erez A, Sagi I, Esmon CT, Ruf W, Lapidot T. Corrigendum: PAR1 signaling regulates the retention and recruitment of EPCR-expressing bone marrow hematopoietic stem cells. Nat Med. 2016 Apr;22(4):446. [Abstract] PMID: 27050594
Lattenist L, Jansen MP, Teske G, Claessen N, Meijers JC, Rezaie AR, Esmon CT, Florquin S, Roelofs JJ. Activated protein C protects against renal ischaemia/reperfusion injury, independent of its anticoagulant properties. Thromb Haemost. 2016 Jul 4;116(1):124-33. Epub 2016 Apr 7. [Abstract] PMID: 27052416
Shaw MA, Kombrinck KW, McElhinney KE, Sweet DR, Flick MJ, Palumbo JS, Cheng M, Esmon NL, Esmon CT, Brill A, Wagner DD, Degen JL, Mullins ES. Limiting prothrombin activation to meizothrombin is compatible with survival but significantly alters hemostasis in mice. Blood. 2016 Jun 1. pii: blood-2015-11-680280. [Epub ahead of print] [Abstract] PMID: 27252233
Functional & Chemical Genomics Research Program
Borras E, San Lucas FA, Chang K,…, Jones DA, Davies GE, Edelmann W, Ehli EA, Lynch PM, Hawk ET, Capella G, Scheet P, Vilar E. Genomic Landscape of Colorectal Mucosa and Adenomas. Cancer Prev Res (Phila). 2016 Jun;9(6):417-27. [Abstract] PMCID: PMC4941624
Pei W, Xu L, Varshney GK, Carrington B, Bishop K, Jones M, Huang SC, Idol J, Pretorius PR, Beirl A, Schimmenti LA, Kindt KS, Sood R, Burgess SM. Additive reductions in zebrafish PRPS1 activity result in a spectrum of deficiencies modeling several human PRPS1-associated diseases. Sci Rep. 2016 Jul 18;6:29946. [Abstract] PMCID: PMC4947902
Varshney GK, Carrington B, Pei W, Bishop K, Chen Z, Fan C, Xu L, Jones M, LaFave MC, Ledin J, Sood R, Burgess SM. A high-throughput functional genomics workflow based on CRISPR/Cas9-mediated targeted mutagenesis in zebrafish. Nat Protoc. 2016 Dec;11(12):2357-2375. [Abstract] PMID: 27809318
Varshney GK, Burgess SM. DNA-guided genome editing using structure-guided endonucleases. Genome Biol. 2016 Sep 15;17(1):187. [Abstract] PMCID: PMC5025577
Genetic Models of Disease Research Program
Miller KG. Keeping Neuronal Cargoes on the Right Track: New Insights into Regulators of Axonal Transport. Neuroscientist. 2016 May 6. pii: 1073858416648307. [Epub ahead of print] Review. [Abstract] PMID: 27154488
Protein Studies
Ghosh AK, Reddy BS, Yen YC, Cardenas E, Rao KV, Downs D, Huang X, Tang J, Mesecar AD. Design of Potent and Highly Selective Inhibitors for Human β-Secretase 2 (Memapsin 1), a Target for Type 2 Diabetes. Chem Sci. 2016 May 1;7:3117-3122. Epub 2016 Feb 4. [Abstract] PMCID: PMC4916918
* Indicates publications by more than one department or group.
