OMRF Publications for 2013
Advanced Magnetic Resonance Center
Floyd RA, Castro Faria Neto HC, Zimmerman GA, Hensley K, Towner RA. Nitrone-based Therapeutics for Neurodegenerative Diseases. Their use alone or in Combination with Lanthionines. Free Radic Biol Med 2013. [Abstract] EPub
Gomez-Mejiba SE, Zhai Z, Della-Vedova MC, Munoz MD, Chatterjee S, Towner RA, Hensley K, Floyd RA, Mason RP, Ramirez DC. Immuno-spin trapping from biochemistry to medicine: Advances, challenges, and pitfalls. Focus on protein-centered radicals. Biochim Biophys Acta 2013. [Abstract] EPub
Piao D, Towner RA, Smith N, Chen WR. Magnetothermoacoustics from magnetic nanoparticles by short bursting or frequency chirped alternating magnetic field: A theoretical feasibility analysis. Med Phys 40:063301, 2013. [Abstract] EPub
Towner RA, Gillespie DL, Schwager A, Saunders DG, Smith N, Njoku CE, Krysiak RS, III, Larabee C, Iqbal H, Floyd RA, Bourne DW, Abdullah O, Hsu EW, Jensen RL. Regression of glioma tumor growth in F98 and U87 rat glioma models by the Nitrone OKN-007. Neuro Oncol 15:330-340, 2013. [Abstract]
* Towner RA, Jensen RL, Colman H, Vaillant B, Smith N, Casteel R, Saunders D, Gillespie DL, Silasi-Mansat R, Lupu F, Giles CB, Wren JD. ELTD1, A Potential new biomarker for gliomas. Neurosurgery 72:77-791, 2013. [Abstract]
* Towner RA, Smith N, Saunders D, Lupu F, Silasi-Mansat R, West M, Ramirez DC, Gomez-Mejiba SE, Bonini MG, Mason RP, Ehrenshaft M, Hensley K. In Vivo Detection of Free Radicals using Molecular MRI and Immuno-Spin-Trapping in a Mouse Models for Amyotrophic Lateral Sclerosis (ALS). Free Radic Biol Med 2013. [Abstract] EPub
Arthritis and Clinical Immunology Research Program
Aggarwal R, Sestak AL, Chakravarty EF, Harley JB, Scofield RH. Excess Female Siblings and Male Fetal Loss in Families with Systemic Lupus Erythematosus. J Rheumatol 40:430-434, 2013. [Abstract]
Andrews SF, Zhang Q, Lim S, Li L, Lee JH, Zheng NY, Huang M, Taylor WM, Farris AD, Ni D, Meng W, Luning Prak ET, Wilson PC. Global analysis of B cell selection using an immunoglobulin light chain-mediated model of autoreactivity. J Exp Med 210:125-142,2013. [Abstract]
Belot A, Kasher PR, Trotter EW, Foray AP, Debaud AL, Rice GI, Szynkiewicz M, Zabot MT, Rouvet I, Bhaskar SS, Daly SB, Dickerson JE, Mayer J, O’Sullivan J, Juillard L, Urquhart JE, Fawdar S, Marusiak AA, Stephenson N, Waszkowycz B, Beresford MW, Biesecker LG, Black GM, Rene C, Eliaou JF, Fabien N, Ranchin B, Cochat P, Gaffney PM, Rozenberg F, Lebon P, Malcus C, Crow YJ, Brognard J, Bonnefoy N. Protein kinase C delta deficiency causes mendelian systemic lupus erythematosus with B-cell defective apoptosis and hyperproliferation. Arthritis Rheum 2013. [Abstract] EPub
Boackle SA, Freedman BI, Scofield RH, Stevens AM, Vyse TJ, Criswell LA, Moser KL, Alarcón-Riquelme ME, Langefeld CD, Harley JB, Gilkeson GS. Variable Association of Reactive Intermediate Genes with Systemic Lupus Erythematosus in Populations with Different African Ancestry. J Rheumatol 2013. [Abstract] EPub
Centola M, Cavet G, Shen Y, Ramanujan S, Knowlton N, Swan KA, Turner M, Sutton C, Smith DR, Haney DJ, Chernoff D, Hesterberg LK, Carulli JP, Taylor PC, Shadick NA, Weinblatt ME, Curtis JR. Development of a multi-biomarker disease activity test for rheumatoid arthritis. PLoS One 8:e60635, 2013. [Abstract]
Chakravarty E, Michaud K, Katz R, Wolfe F. Increased incidence of herpes zoster among patients with systemic lupus erythematosus. Lupus 22:238-0244, 2013. [Abstract]
* Coit P, Jeffries M, Altorok N, Dozmorov MG, Koelsch KA, Wren JD, Merrill JT, McCune WJ, Sawalha AH. Genome-wide DNA methylation study suggests epigenetic accessibility and transcriptional poising of interferon-regulated genes in naive CD4+ T cells from lupus patients. J Autoimmun 2013. [Abstract] EPub
* Deng Y, Zhao J, Sakurai D, Kaufman KM, Edberg JC, Kimberly RP, Kamen DL, Gilkeson GS, Jacob CO, Scofield RH, Langefeld CD, Kelly JA, Ramsey-Goldman R, Petri MA, Reveille JD, Vila LM, Alarcon GS, Vyse TJ, Pons-Estel BA, gentine Collaborative Group, Freedman BI, Gaffney PM, Sivils KM, James JA, Gregersen PK, Anaya JM, Niewold TB, Merrill JT, Criswell LA, Stevens AM, Boackle SA, Cantor RM, Chen W, Grossman JM, Hahn BH, Harley JB, Alarcon-Riquelme ME, BIOLUPUS and GENLES Networks, Brown EE, Tsao BP. MicroRNA-3148 Modulates Allelic Expression of Toll-Like Receptor 7 Variant Associated with Systemic Lupus Erythematosus. PLoS Genet 9:e1003336, 2013. [Abstract]
Dumas EK, Nguyen ML, Cox PM, Rodgers H, Peterson JL, James JA, Farris AD. Stochastic humoral immunity to Bacillus anthracis protective antigen: Identification of anti-peptide IgG correlating with seroconversion to Lethal Toxin neutralization. Vaccine 31:1856-1863,2013. [Abstract]
Herraez DL, Martinez-Bueno M, Riba L, de la Torre IG, Sacnun M, Goni M, Berbotto G, Paira S, Musuruana JL, Graf C, Alvarellos A, Messina OD, Babini A, Strusberg I, Marcos JC, Scherbarth H, Spindler A, Quinteros A, Toloza S, Moreno JL, Catoggio LJ, Tate G, Eimon A, Citera G, Pellet AC, Nasswetter G, Cardiel MH, Miranda P, Ballesteros F, Esquivel-Valerio JA, Maradiaga-Cecena A, Acevedo-Vasquez EM, Garcia CG, Tusie-Luna T, Pons-Estel B, Alarcon-Riquelme ME. Rheumatoid arthritis in Latin Americans enriched for Amerindian ancestry is associated with loci in chromosomes 1, 12,13, and HLA class II region. Arthritis Rheum 2013. [Abstract] EPub
Hinks A, Cobb J, Marion MC, Prahalad S, Sudman M, Bowes J, Martin P, Comeau ME, Sajuthi S, Andrews R, Brown M, Chen WM, Concannon P, Deloukas P, Edkins S, Eyre S, Gaffney PM, Guthery SL, Guthridge JM, Hunt SE, James JA, Keddache M, Moser KL, Nigrovic PA, Onengut-Gumuscu S, Onslow ML, Rose CD, Rich SS, Steel KJ, Wakeland EK, Wallace CA, Wedderburn LR, Woo P, Boston Children’s JIA Registry, British Society of Paediatric and Adolescent Rheumatology (BSPAR) Study Group, Childhood Arthritis Prospective Study (CAPS), Childhood Arthritis Response to Medication Study (CHARMS), German Society for Pediatric Rheumatology (GKJR), JIA Gene Expression Study, NIAMS JIA Genetic Registry, TREAT Study, United Kingdom Juvenile Idiopathic Arthritis Genetics Consortium (UKJIAGC), Bohnsack JF, Haas JP, Glass DN, Langefeld CD, Thomson W, Thompson SD. Dense genotyping of immune-related disease regions identifies 14 new susceptibility loci for juvenile idiopathic arthritis. Nat Genet 45:664-669, 2013. [Abstract]
Igoe A, Scofield RH. Autoimmunity and infection in Sjogren’s syndrome. Curr Opin Rheumatol 25:480-487, 2013. [Abstract]
* Kaufman KM, Zhao J, Kelly JA, Hughes T, Adler A, Sanchez E, Ojwang JO, Langefeld CD, Ziegler JT, Williams AH, Comeau ME, Marion MC, Glenn SB, Cantor RM, Grossman JM, Hahn BH, Song YW, Yu CY, James JA, Guthridge JM, Brown EE, Alarcon GS, Kimberly RP, Edberg JC, Ramsey-Goldman R, Petri MA, Reveille JD, Vila LM, Anaya JM, Boackle SA, Stevens AM, Freedman BI, Criswell LA, Pons-Estel BA, on behalf of the Argentine Collaborative Group, Lee JH, Lee JS, Chang DM, Scofield RH, Gilkeson GS, Merrill JT, Niewold TB, Vyse TJ, Bae SC, Alarcon-Riquelme ME, on behalf of the BIOLUPUS network, Jacob CO, Sivils KM, Gaffney PM, Harley JB, Sawalha AH, Tsao BP. Fine mapping of Xq28: both MECP2 and IRAK1 contribute to risk for systemic lupus erythematosus in multiple ancestral groups. Ann Rheum Dis 72:437-444, 2013. [Abstract]
Koelsch KA, Wang Y, Maier-Moore JS, Sawalha AH, Wren JD. GFP Affects Human T Cell Activation and Cytokine Production following In Vitro Stimulation. PLoS One 8:e50068, 2013. [Abstract]
Koelsch KA, Webb R, Jeffries M, Dozmorov MG, Frank MB, Guthridge JM, James JA, Wren JD, Sawalha AH. Functional characterization of the MECP2/IRAK1 lupus risk haplotype in human T cells and a human MECP2 transgenic mouse. J Autoimmun 41:168-174, 2013. [Abstract]
Kurien BT, Dsouza A, Igoe A, Lee YJ, Maier-Moore JS, Gordon T, Jackson M, Scofield RH. Immunization with 60 kD Ro peptide produces different stages of pre-clinical autoimmunity in a Sjogren’s syndrome-model among multiple strains of inbred mice. Clin Exp Immunol 2013. [Abstract] EPub
Langen ES, Chakravarty EF, Liaquat M, El-Sayed YY, Druzin ML. High Rate of Preterm Birth in Pregnancies Complicated by Rheumatoid Arthritis. Am J Perinatol 2013. [Abstract] EPub
Levin AM, Iannuzzi MC, Montgomery CG, Trudeau S, Datta I, McKeigue P, Fischer A, Nebel A, Rybicki BA. Association of ANXA11 genetic variation with sarcoidosis in African Americans and European Americans. Genes Immun 14:13-18,2013. [Abstract]
Maiti AK, Nath SK. Gene network analysis of small molecules with autoimmune disease associated genes predicts a novel strategy for drug efficacy. Autoimmun Rev 12:510-522,2013. [Abstract]
* Molineros JE, Maiti AK, Sun C, Looger LL, Han S, Kim-Howard X, Glenn S, Adler A, Kelly JA, Niewold TB, Gilkeson GS, Brown EE, Alarcon GS, Edberg JC, Petri M, Ramsey-Goldman R, Reveille JD, Vila LM, Freedman BI, Tsao BP, Criswell LA, Jacob CO, Moore JH, Vyse TJ, Langefeld CL, Guthridge JM, Gaffney PM, Moser KL, Scofield RH, Alarcon-Riquelme ME, BIOLUPUS Network, Williams SM, Merrill JT, James JA, Kaufman KM, Kimberly RP, Harley JB, Nath SK. Admixture Mapping in Lupus Identifies Multiple Functional Variants within IFIH1 Associated with Apoptosis, Inflammation, and Autoantibody Production. PLoS Genet 9:e1003222, 2013. [Abstract]
* Ramos PS, Oates JC, Kamen DL, Williams AH, Gaffney PM, Kelly JA, Kaufman KM, Kimberly RP, Niewold TB, Jacob CO, Tsao BP, Alarcón GS, Brown EE, Edberg JC, Petri MA, Ramsey-Goldman R, Reveille JD, Vilá LM, James JA, Guthridge JM, Merrill JT, Boackle SA, Freedman BI, Scofield RH, Stevens AM, Vyse TJ, Criswell LA, Moser KL, Alarcón-Riquelme ME, Langefeld CD, Harley JB, Gilkeson GS. Variable Association of Reactive Intermediate Genes with Systemic Lupus Erythematosus in Populations with Different African Ancestry. J Rheumatol 2013. [Abstract] EPub
Requena T, Gazquez I, Moreno A, Batuecas A, Aran I, Soto-Varela A, Santos-Perez S, Perez N, Perez-Garrigues H, Lopez-Nevot A, Martin E, Sanz R, Perez P, Trinidad G, Alarcón-Riquelme ME, Teggi R, Zagato L, Lopez-Nevot MA, Lopez-Escamez JA. Allelic variants in TLR10 gene may influence bilateral affectation and clinical course of Meniere’s disease. Immunogenetics 65:345-355,2013. [Abstract]
Segal BM, Pogatchnik B, Henn L, Rudser K, Sivils KM. Pain Severity and Neuropathic Pain symptoms in primary Sjogren’s syndrome: A comparison study of seropositive and seronegative Sjogren’s syndrome. Arthritis Care Res (Hoboken) 2013. [Abstract] EPub
Shah D, Sah S, Nath SK. Interaction between glutathione and Apoptosis in Systemic Lupus Erythematosus. Autoimmun Rev 12:741-751,2013. [Abstract]
Shah M, Mamyrova G, Targoff IN, Huber AM, Malley JD, Rice MM, Miller FW, Rider LG, with the Childhood Myositis Heterogeneity Collaborative Study Group. The Clinical Phenotypes of the Juvenile Idiopathic Inflammatory Myopathies. Medicine (Baltimore) 2013:92:25-41. [Abstract]
Shah M, Targoff IN, Rice MM, Miller FW, Rider LG, with the Childhood Myositis Heterogeneity Collaborative Study Group. Ultraviolet radiation exposure is associated with clinical and autoantibody phenotypes in Juvenile Myositis. Arthritis Rheum 2013. [Abstract] EPub
Smith K, Muther JJ, Duke AL, McKee E, Zheng NY, Wilson PC, James JA. Fully human monoclonal antibodies from antibody secreting cells after vaccination with Pneumovax(R)23 are serotype specific and facilitate opsonophagocytosis. Immunobiology 218:745-754, 2013. [Abstract]
Thanou A, Ali T, Haq O, Kaitha S, Morton J, Stavrakis S, Humphrey MB. Utilization of Preventive Measures for Glucocorticoid-Induced Osteoporosis among Veterans with Inflammatory Bowel Disease. ISRN Gastroenterol 2013:862312, 2013. [Abstract]
* Towner RA, Jensen RL, Colman H, Vaillant B, Smith N, Casteel R, Saunders D, Gillespie DL, Silasi-Mansat R, Lupu F, Giles CB, Wren JD. ELTD1, A Potential New Biomarker for Gliomas. Neurosurgery 72:77-91, 2013. [Abstract]
Waubant E, Mowry EM, Krupp L, Chitnis T, Yeh EA, Kuntz N, Ness J, Belman A, Milazzo M, Gorman M, Weinstock-Guttman B, Rodriguez M, James JA. Antibody response to common viruses and human leukocyte antigen-DRB1 in pediatric multiple sclerosis. Mult Scler 19:891-895,2013. [Abstract]
Cardiovascular Biology Research Program
Ahmed I, Roy B, Chandrakesan P, Venugopal A, Xia L, Jensen R, Anant S, Umar S. Evidence of functional cross talk between the Notch and NF-kappaB pathways in nonneoplastic hyperproliferating colonic epithelium. Am J Physiol Gastrointest Liver Physiol 304:G356-G370, 2013. [Abstract]
Davis RB, Curtis CD, Griffin CT. BRG1 promotes COUP-TFII expression and venous specification during embryonic vascular development. Development 140:1272-1281, 2013. [Abstract]
Huang Q, Qin L, Dai S, Zhang H, Pasula S, Zhou H, Chen H, Min W. AIP1 Suppresses Atherosclerosis by Limiting Hyperlipidemia-Induced Inflammation and Vascular Endothelial Dysfunction. Arterioscler Thromb Vasc Biol 33:795-804, 2013. [Abstract]
Johansson ME, Gustafsson JK, Holmen-Larsson J, Jabbar KS, Xia L, Xu H, Ghishan FK, Carvalho FA, Gewirtz AT, Sjovall H, Hansson GC. Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis. Gut 2013. [Abstract]
Kim YM, Lee JY, Xia L, Mulvihill JJ, Li S. Trisomy 8: a common finding in mouse embryonic stem (ES) cell lines. Mol Cytogenet 6:3, 2013. [Abstract]
Lupu C, Herlea O, Tang H, Lijnen RH, Lupu F. Plasmin-dependent proteolysis of Tissue Factor Pathway Inhibitor in a mouse model of endotoxemia. J Thromb Haemost 11:142-148, 2013.2013. [Abstract]
Qu H, Ricklin D, Bai H, Chen H, Reis ES, Maciejewski M, Tzekou A, Deangelis RA, Resuello RR, Lupu F, Barlow PN, Lambris JD. New analogs of the clinical complement inhibitor compstatin with subnanomolar affinity and enhanced pharmacokinetic properties. Immunobiology 218:496-505,2013. [Abstract]
Tessneer KL, Pasula S, Cai X, Dong Y, Liu X, Yu L, Hahn S, McManus J, Chen Y, Chang B, Chen H. Endocytic adaptor protein epsin is elevated in prostate cancer and required for cancer progression. ISRN Oncol 2013:420597, 2013. [Abstract]
Wang Y, Zhao L, Suzuki A, Lian L, Min SH, Wang Z, Litvinov RI, Stalker TJ, Yago T, Klopocki AG, Schmidtke DW, Yin H, Choi JK, McEver RP, Weisel JW, Hartwig JH, Abrams CS. Platelets lacking PIP5KIgamma have normal integrin activation but impaired cytoskeletal-membrane integrity and adhesion. Blood 2013. [Abstract] EPub
Yao L, Heuser-Baker J, Herlea-Pana O, Barlic-Dicen J. Bone marrow endothelial progenitors in atherosclerotic plaque resolution. Organogenesis 9: 2013. [Abstract] EPub
Zhang Y, Jiang N, Zarnitsyna VI, Klopocki AG, McEver RP, Zhu C. P-selectin glycoprotein ligand-1 forms dimeric interactions with e-selectin but monomeric interactions with L-selectin on cell surfaces. PLoS One 8:e57202, 2013. [Abstract]
Cell Cycle and Cancer Biology Research Program
Earnshaw WC, Allshire RC, Black BE, Bloom K, Brinkley BR, Brown W, Cheeseman IM, Choo KH, Copenhaver GP, Deluca JG, Desai A, Diekmann S, Erhardt S, Fitzgerald-Hayes M, Foltz D, Fukagawa T, Gassmann R, Gerlich DW, Glover DM, Gorbsky GJ, Harrison SC, Heun P, Hirota T, Jansen LE, Karpen G, Kops GJ, Lampson MA, Lens SM, Losada A, Luger K, Maiato H, Maddox PS, Margolis RL, Masumoto H, McAinsh AD, Mellone BG, Meraldi P, Musacchio A, Oegema K, O’Neill RJ, Salmon ED, Scott KC, Straight AF, Stukenberg PT, Sullivan BA, Sullivan KF, Sunkel CE, Swedlow JR, Walczak CE, Warburton PE, Westermann S, Willard HF, Wordeman L, Yanagida M, Yen TJ, Yoda K, Cleveland DW. Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant. Chromosome Res 2013. [Abstract] EPub
Guiraldelli MF, Eyster C, Wilkerson JL, Dresser ME, Pezza RJ. Mouse HFM1/Mer3 Is Required for Crossover Formation and Complete Synapsis of Homologous Chromosomes during Meiosis. PLoS Genet 9:e1003383, 2013. [Abstract]
Liu H, Rankin S, Yu H. Phosphorylation-enabled binding of SGO1-PP2A to cohesin protects sororin and centromeric cohesion during mitosis. Nat Cell Biol 15:40-49,2013. [Abstract]
Meyer RE, Kim S, Obeso D, Straight PD, Winey M, Dawson DS. Mps1 and Ipl1/Aurora B Act Sequentially to Correctly Orient Chromosomes on the Meiotic Spindle of Budding Yeast. Science 339:1071-1074, 2013. [Abstract]
Clinical Pharmacology Research Program
* Coit P, Jeffries M, Altorok N, Dozmorov MG, Koelsch KA, Wren JD, Merrill JT, McCune WJ, Sawalha AH. Genome-wide DNA methylation study suggests epigenetic accessibility and transcriptional poising of interferon-regulated genes in naive CD4+ T cells from lupus patients. J Autoimmun 2013. [Abstract] EPub
* Deng Y, Zhao J, Sakurai D, Kaufman KM, Edberg JC, Kimberly RP, Kamen DL, Gilkeson GS, Jacob CO, Scofield RH, Langefeld CD, Kelly JA, Ramsey-Goldman R, Petri MA, Reveille JD, Vila LM, Alarcon GS, Vyse TJ, Pons-Estel BA, gentine Collaborative Group, Freedman BI, Gaffney PM, Sivils KM, James JA, Gregersen PK, Anaya JM, Niewold TB, Merrill JT, Criswell LA, Stevens AM, Boackle SA, Cantor RM, Chen W, Grossman JM, Hahn BH, Harley JB, Alarcon-Riquelme ME, BIOLUPUS and GENLES Networks, Brown EE, Tsao BP. MicroRNA-3148 Modulates Allelic Expression of Toll-Like Receptor 7 Variant Associated with Systemic Lupus Erythematosus. PLoS Genet 9:e1003336, 2013. [Abstract]
* Kaufman KM, Zhao J, Kelly JA, Hughes T, Adler A, Sanchez E, Ojwang JO, Langefeld CD, Ziegler JT, Williams AH, Comeau ME, Marion MC, Glenn SB, Cantor RM, Grossman JM, Hahn BH, Song YW, Yu CY, James JA, Guthridge JM, Brown EE, Alarcon GS, Kimberly RP, Edberg JC, Ramsey-Goldman R, Petri MA, Reveille JD, Vila LM, Anaya JM, Boackle SA, Stevens AM, Freedman BI, Criswell LA, Pons-Estel BA, on behalf of the Argentine Collaborative Group, Lee JH, Lee JS, Chang DM, Scofield RH, Gilkeson GS, Merrill JT, Niewold TB, Vyse TJ, Bae SC, Alarcon-Riquelme ME, on behalf of the BIOLUPUS network, Jacob CO, Sivils KM, Gaffney PM, Harley JB, Sawalha AH, Tsao BP. Fine mapping of Xq28: both MECP2 and IRAK1 contribute to risk for systemic lupus erythematosus in multiple ancestral groups. Ann Rheum Dis 72:437-444,2013. [Abstract]
Merrill JT. Co-stimulatory molecules as targets for treatment of lupus. Clin Immunol 2013. [Abstract] EPub
* Molineros JE, Maiti AK, Sun C, Looger LL, Han S, Kim-Howard X, Glenn S, Adler A, Kelly JA, Niewold TB, Gilkeson GS, Brown EE, Alarcon GS, Edberg JC, Petri M, Ramsey-Goldman R, Reveille JD, Vila LM, Freedman BI, Tsao BP, Criswell LA, Jacob CO, Moore JH, Vyse TJ, Langefeld CL, Guthridge JM, Gaffney PM, Moser KL, Scofield RH, Alarcon-Riquelme ME, BIOLUPUS Network, Williams SM, Merrill JT, James JA, Kaufman KM, Kimberly RP, Harley JB, Nath SK. Admixture Mapping in Lupus Identifies Multiple Functional Variants within IFIH1 Associated with Apoptosis, Inflammation, and Autoantibody Production. PLoS Genet 9:e1003222, 2013. [Abstract]
Parker B, Urowitz MB, Gladman DD, Lunt M, Bae SC, Sanchez-Guerrero J, Romero-Diaz J, Gordon C, Wallace DJ, Clarke AE, Bernatsky S, Ginzler EM, Isenberg DA, Rahman A, Merrill JT, Alarcon GS, Fessler BJ, Fortin PR, Hanly JG, Petri M, Steinsson K, Dooley MA, Manzi S, Khamashta MA, Ramsey-Goldman R, Zoma AA, Sturfelt GK, Nived O, Arranow C, Mackay M, Ramos-Casals M, Van Vollenhoven RF, Kalunian KC, Ruiz-Irastorza G, Lim S, Kamen DL, Peschken CA, Inanc M, Bruce IN. Clinical associations of the metabolic syndrome in systemic lupus erythematosus: data from an international inception cohort. Ann Rheum Dis 2013. [Abstract] EPub
Peterfy CG, Olech E, Dicarlo JC, Merrill JT, Countryman PJ, Gaylis NB. Monitoring cartilage loss in the hands and wrists in rheumatoid arthritis with magnetic resonance imaging in a multi-center clinical trial: IMPRESS (NCT00425932). Arthritis Res Ther 15:R44, 2013. [Abstract]
* Ramos PS, Oates JC, Kamen DL, Williams AH, Gaffney PM, Kelly JA, Kaufman KM, Kimberly RP, Niewold TB, Jacob CO, Tsao BP, Alarcón GS, Brown EE, Edberg JC, Petri MA, Ramsey-Goldman R, Reveille JD, Vilá LM, James JA, Guthridge JM, Merrill JT, Boackle SA, Freedman BI, Scofield RH, Stevens AM, Vyse TJ, Criswell LA, Moser KL, Alarcón-Riquelme ME, Langefeld CD, Harley JB, Gilkeson GS. Variable Association of Reactive Intermediate Genes with Systemic Lupus Erythematosus in Populations with Different African Ancestry. J Rheumatol 2013. [Abstract] EPub
Stohl W, Merrill JT, McKay JD, Lisse JR, Zhong ZJ, Freimuth WW, Genovese MC. Efficacy and Safety of Belimumab in Patients with Rheumatoid Arthritis: A Phase II, Randomized, Double-blind, Placebo-controlled, Dose-ranging Study. J Rheumatol 40:579-589, 2013. [Abstract]
Thanou A, Merrill JT. Top 10 things to know about lupus activity measures. Curr Rheumatol Rep 15:334, 2013. [Abstract]
Coagulation Biology Laboratory
Bock F, Shahzad K, Wang H, Stoyanov S, Wolter J, Dong W, Pelicci PG, Kashif M, Ranjan S, Schmidt S, Ritzel R, Schwenger V, Reymann KG, Esmon CT, Madhusudhan T, Nawroth PP, Isermann B. Activated protein C ameliorates diabetic nephropathy by epigenetically inhibiting the redox enzyme p66Shc. Proc Natl Acad Sci U S A 110:648-653, 2013. [Abstract]
Borissoff JI, Otten JJ, Heeneman S, Leenders P, van Oerle R., Soehnlein O, Loubele ST, Hamulyak K, Hackeng TM, Daemen MJ, Degen JL, Weiler H, Esmon CT, van Ryn J., Biessen EA, Spronk HM, Ten Cate H. Genetic and Pharmacological Modifications of Thrombin Formation in Apolipoprotein E-deficient Mice Determine Atherosclerosis Severity and Atherothrombosis Onset in a Neutrophil-Dependent Manner. PLoS One 8:e55784, 2013. [Abstract]
Esmon CT. Molecular circuits in thrombosis and inflammation. Thromb Haemost 109:416-420, 2013. [Abstract]
Kager LM, Wiersinga WJ, Roelofs JJ, Meijers JC, Zeerleder SS, Esmon CT, Van’t Veer C, van der Poll T. Endogenous protein C has a protective role during gram-negative pneumosepsis (melioidosis). J Thromb Haemost 11:282-292,2013. [Abstract]
Kager LM, Roelofs JJ, de Vos AF, Wieland CW, Schouten M, Meijers JC, Isermann B, Van’t Veer C, Esmon CT, van der Poll T. The endothelial protein C receptor and activated protein C play a limited role in host defense during experimental tuberculosis. Thromb Haemost 109: 726-737,2013. [Abstract]
Nayak RC, Keshava S, Esmon CT, Pendurthi UR, Rao LV. Rab GTPases Regulate Endothelial Cell Protein C Receptor-Mediated Endocytosis and Trafficking of Factor VIIa. PLoS One 8:e59304, 2013. [Abstract]
Schaffner F, Yokota N, Carneiro-Lobo T, Kitano M, Schaffer M, Anderson GM, Mueller BM, Esmon CT, Ruf W. Endothelial Protein C Receptor Function in Murine and Human Breast Cancer Development. PLoS One 8:e61071, 2013. [Abstract]
Vadivel K, Agah S, Messer AS, Cascio D, Bajaj MS, Krishnaswamy S, Esmon CT, Padmanabhan K, Bajaj SP. Structural and Functional Studies of gamma-Carboxyglutamic Acid Domains of Factor VIIa and Activated Protein C: Role of Magnesium at Physiological Calcium. J Mol Biol 425:1961-1981,2013. [Abstract]
Free Radical Biology and Aging Research Program
Bhatnagar A, Unal H, Jagannathan R, Kaveti S, Duan ZH, Yong S, Vasanji A, Kinter M, Desnoyer R, Karnik SS. Interaction of G-Protein betagamma Complex with Chromatin Modulates GPCR-Dependent Gene Regulation. PLoS One 8:e52689, 2013. [Abstract]
Ghosh S, Willard B, Comhair S, Dibello P, Xu W, Shiva S, Aulak KS, Kinter M, Erzurum SC. Disulfide bond as a switch for copper-zinc superoxide dismutase activity in asthma. Antioxid Redox Signal 18:412-423, 2013. [Abstract]
Hallgren KW, Zhang D, Kinter M, Willard B, Berkner KL. Methylation of gamma-carboxylated Glu (Gla) allows detection by liquid chromatography-mass spectrometry and the identification of Gla residues in the gamma-glutamyl carboxylase. J Proteome Res 2013. [Abstract] EPub
Macdonald MJ, Langberg EC, Tibell A, Sabat G, Kendrick MA, Szweda LI, Ostenson CG. Identification of ATP Synthase As a Lipid Peroxide Protein Adduct in Pancreatic Islets From Humans With and Without Type 2 Diabetes Mellitus. J Clin Endocrinol Metab 98:E727-E731, 2013. [Abstract]
McLain AL, Cormier PJ, Kinter M, Szweda LI. Glutathionylation of alpha-Ketoglutarate Dehydrogenase: The Chemical Nature and Relative Susceptibility of the Cofactor Lipoic Acid to Modification. Free Radic Biol Med 61C:161-169, 2013. [Abstract]
O’Conor CJ, Griffin TM, Liedtke W, Guilak F. Increased susceptibility of Trpv4-deficient mice to obesity and obesity-induced osteoarthritis with very high-fat diet. Ann Rheum Dis 72:300-304, 2013. [Abstract]
Perry EA, Castellani RJ, Moreira PI, Nunomura AA, Liu Q, Harris PL, Sayre LM, Szweda PA, Szweda LI, Zhu X, Smith MA, Perry G. Neurofilaments are the Major Neuronal Target of Hydroxynonenal Mediated Protein Crosslinks. Free Radic Res 2013. [Abstract] EPub
Rindler PM, Plafker SM, Szweda LI, Kinter M. High dietary fat selectively increases catalase expression within cardiac mitochondria. J Biol Chem 288:1979-1990,2013. [Abstract]
* Towner RA, Smith N, Saunders D, Lupu F, Silasi-Mansat R, West M, Ramirez DC, Gomez-Mejiba SE, Bonini MG, Mason RP, Ehrenshaft M, Hensley K. In Vivo Detection of Free Radicals using Molecular MRI and Immuno-Spin-Trapping in a Mouse Models for Amyotrophic Lateral Sclerosis (ALS). Free Radic Biol Med 2013. [Abstract] EPub
Vadvalkar SS, Baily CN, Matsuzaki S, West M, Tesiram YA, Humphries KM. Metabolic inflexibility and protein lysine acetylation in heart mitochondria of a chronic model of Type 1 diabetes. Biochem J 449:253-261, 2013. [Abstract]
Genetic Models of Disease Research Program
Edwards SL, Yu SC, Hoover CM, Phillips BC, Richmond JE, Miller KG. An Organelle Gatekeeper Function for Caenorhabditis elegans UNC-16 (JIP3) at the Axon Initial Segment. Genetics 194:143-161, 2013. [Abstract]
Immunobiology and Cancer Research Program
Iwayama T, Olson LE. Involvement of PDGF in Fibrosis and Scleroderma: Recent Insights from Animal Models and Potential Therapeutic Opportunities. Curr Rheumatol Rep 15:304, 2013. [Abstract]
Liu C, Jin R, Wang HC, Tang H, Liu YF, Qian XP, Sun XY, Ge Q, Sun XH, Zhang Y. Id1 expression promotes peripheral CD4 T cell proliferation and survival upon TCR activation without co-stimulation. Biochem Biophys Res Commun 2013. [Abstract] EPub
Shen W, Tremblay MS, Deshmukh VA, Wang W, Filippi CM, Harb G, Zhang YQ, Kamireddy A, Baaten JE, Jin Q, Wu T, Swoboda JG, Cho CY, Li J, Laffitte BA, McNamara P, Glynne R, Wu X, Herman AE, Schultz PG. Small-Molecule Inducer of beta Cell Proliferation Identified by High-Throughput Screening. J Am Chem Soc 135:1669-1672, 2013. [Abstract]
Thompson LF, Tsukamoto H, Chernogorova P, Zeiser R. A delicate balance: CD73-generated adenosine limits the severity of graft vs. host disease but also constrains the allogeneic graft vs. tumor effect. Oncoimmunology 2:e22107, 2013. [Abstract]
Zhang Q, Iida R, Yokota T, Kincade PW. Early events in lymphopoiesis: an update. Curr Opin Hematol 2013. [Abstract] EPub
Zhao Y, Ling F, Wang HC, Sun XH. Chronic TLR Signaling Impairs the Long-Term Repopulating Potential of Hematopoietic Stem Cells of Wild Type but Not Id1 Deficient Mice. PLoS One 8:e55552, 2013. [Abstract]
Protein Studies Research Program
Coughlan K, Huang X, He X, Chung CH, Li G, Tang J. Expression and processing of fluorescent fusion proteins of amyloid precursor protein (APP). Biochim Biophys Acta 1833:1562-1571, 2013. [Abstract]
Wu H, Downs D, Ghosh K, Ghosh AK, Staib P, Monod M, Tang J, Puatanachokchai R. Candida albicans secreted aspartic proteases 4-6 induce apoptosis of epithelial cells by a novel Trojan horse mechanism. FASEB J 27:2132-2144,2013. [Abstract]
* Indicates publications by more than one department or group.
Additional Publications:
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