Robert Silasi-Mansat, Ph.D.
Research Assistant Professor
Cardiovascular Biology Research Program
Research
Sepsis is a multi-stage, life-threatening condition that arises when the body has to fight a severe infection that has spread throughout the circulatory system and to the organs. In its most severe form, sepsis can produce cardiovascular collapse and death within hours. Often, it leads to a progressive multiple organ failure that results from widespread blood clot formation and loss of blood flow.
Despite important strides made in understanding sepsis, the related morbidity and mortality rates remain high. Our group aims to investigate bacterial sepsis and to find molecular mechanisms that are dysregulated in the presence of the bacteria or bacterial components in the bloodstream. We are testing new therapies that would prevent or reduce the formation of blood clots during sepsis, which could ultimately prevent organ failure and death.
Publications
Silasi R, Keshari RS, Regmi G, Lupu C, Georgescu C, Simmons JH, Wallisch M, Kohs TCL, Shatzel JJ, Olson SR, Lorentz CU, Puy C, Tucker EI, Gailani D, Strickland S, Gruber A, McCarty OJT, Lupu F. Factor XII plays a pathogenic role in organ failure and death in baboons challenged with Staphylococcus aureus. Blood. 2021 Jul 15;138(2):178-189. doi: 10.1182/blood.2020009345. PMID: 33598692; PMCID: PMC8288658.
Keshari RS, Silasi R, Popescu NI, Georgescu C, Chaaban H, Lupu C, McCarty OJT, Esmon CT, Lupu F. Fondaparinux pentasaccharide reduces sepsis coagulopathy and promotes survival in the baboon model of Escherichia coli sepsis. J Thromb Haemost. 2020 Jan;18(1):180-190. doi: 10.1111/jth.14642. Epub 2019 Oct 16. PMID:31549765; PMCID: PMC6940562.
Silasi R, Keshari RS, Lupu C, Van Rensburg WJ, Chaaban H, Regmi G, Shamanaev A, Shatzel JJ, Puy C, Lorentz CU, Tucker EI, Gailani D, Gruber A, McCarty OJT, Lupu F. Inhibition of contact-mediated activation of factor XI protects baboons against S aureus-induced organ damage and death. Blood Adv. 2019 Feb 26;3(4):658-669. doi: 10.1182/bloodadvances.2018029983. Erratum in: Blood Adv. 2020 Aug 11;4(15):3741. PMID: 30808684; PMCID: PMC6391670.
Keshari RS, Silasi R, Lupu C, Taylor FB Jr, Lupu F. In vivo-generated thrombin and plasmin do not activate the complement system in baboons. Blood. 2017 Dec 14;130(24):2678-2681. doi: 10.1182/blood-2017-06-788216. Epub 2017 Oct 11. PMID: 29021229; PMCID: PMC5731087.
Keshari RS, Silasi R, Popescu NI, Patel MM, Chaaban H, Lupu C, Coggeshall KM, Mollnes TE, DeMarco SJ, Lupu F. Inhibition of complement C5 protects against organ failure and reduces mortality in a baboon model of Escherichia coli sepsis. Proc Natl Acad Sci U S A. 2017 Aug 1;114(31):E6390-E6399. doi:10.1073/pnas.1706818114. Epub 2017 Jul 18. PMID: 28720697; PMCID: PMC5547645.
Contact
Cardiovascular Biology Research Program, MS 45
Oklahoma Medical Research Foundation
825 N.E. 13th Street
Oklahoma City, OK 73104
Phone: 405-271-7483
E-mail: Robert-SilasiMansat@omrf.org
