2015 Scientific Publications

Advanced Magnetic Resonance Center

De Souza PC, Balasubramanian K, Njoku C, Smith N, Gillespie DL, Schwager A, Abdullah O, Ritchey JW, Fung KM, Saunders D, Jensen RL, Towner RA. OKN-007 decreases tumor necrosis and tumor cell proliferation and increases apoptosis in a preclinical F98 rat glioma model. J Magn Reson Imaging 2015. [Abstract] EPub

De Souza PC, Ranjan A, Towner RA. Nanoformulations for therapy of pancreatic and liver cancers. Nanomedicine (Lond) 10:1515-1534, 2015. [Abstract]

* De Souza PC, Smith N, Atolagbe O, Ziegler J, Njoku C, Lerner M, Ehrenshaft M, Mason RP, Meek B, Plafker SM, Saunders D, Mamedova N, Towner RA. OKN-007 decreases free radicals levels in a preclinical F98 rat glioma model. Free Radic Biol Med 2015. [Abstract] EPub

*Dong Y, Wu H, Rahman HN, Liu Y, Pasula S, Tessneer KL, Cai X, Liu X, Chang B, McManus J, Hahn S, Dong J, Brophy ML, Yu L, Song K, Silasi-Mansat R, Saunders D, Njoku C, Song H, Mehta-D’Souza P, Towner R, Lupu F, McEver RP, Xia L, Boerboom D, Srinivasan RS, Chen H. Motif mimetic of epsin perturbs tumor growth and metastasis. J Clin Invest. 2015 Dec;125(12):4349-64. [Abstract] Epub 2015 Nov 16.

Greenwood-Van Meerveld B, Mohammadi E, Tyler K, Van Gordon S, Parker A, Towner R, Hurst R. Mechanisms of visceral organ crosstalk: importance of alterations in permeability in rodent models. J Urol 194:804-811, 2015. [Abstract]

Seong J, Jeong W, Smith N, Towner RA. Hemodynamic effects of long-term morphological changes in the human carotid sinus. J Biomech 48:956-962, 2015. [Abstract]

Tarantini S, Hertelendy P, Tucsek Z, Valcarcel-Ares MN, Smith N, Menyhart A, Farkas E, Hodges EL, Towner R, Deak F, Sonntag WE, Csiszar A, Ungvari Z, Toth P. Pharmacologically-induced neurovascular uncoupling is associated with cognitive impairment in mice. J Cereb Blood Flow Metab 2015. [Abstract] EPub

Towner RA, Ihnat M, Saunders D, Bastian A, Smith N, Pavana RK, Gangjee A. A new anti-glioma therapy, AG119: pre-clinical assessment in a mouse GL261 glioma model. BMC Cancer 15:522, 2015. [Abstract]

* Towner RA, Smith N, Saunders D, Carrizales J, Lupu F, Silasi-Mansat R, Ehrenshaft M, Mason RP. In Vivo targeted molecular magnetic resonance imaging of free radicals in diabetic cardiomyopathy within mice. Free Radic Res 1-17, 2015. [Abstract]

Towner RA, Smith N, Saunders D, Van Gordon SB, Wisniewski AB, Tyler KR, Greenwood-Van Meerveld B, Hurst RE. Contrast enhanced magnetic resonance imaging as a diagnostic tool for assessing bladder permeability and associated colon cross-talk: pre-clinical studies in a rat model. J Urol 193:1394-1400, 2015. [Abstract]

Aging and Metabolism Research Program

Bastian A, Thorpe JE, Disch BC, Bailey-Downs LC, Gangjee A, Devambatla RK, Henthorn J, Humphries KM, Vadvalkar SS, Ihnat MA. A small molecule with anticancer and antimetastatic activities induces rapid mitochondrial-associated necrosis in breast cancer. J Pharmacol Exp Ther 353:392-404, 2015. [Abstract]

Bockus LB, Humphries KM. cAMP-dependent protein kinase (PKA) signaling is impaired in the diabetic heart. J Biol Chem 290:29250-29258, 2015. [Abstract]

* Duan H, Li Y, Lim HY, Wang W. Identification of 5-nitrofuran-2-amide derivatives that induce apoptosis in triple negative breast cancer cells by activating C/EBP-homologous protein expression. Bioorg Med Chem 23:4514-4521,2015. [Abstract]

Evans TM, Jaramillo CA, Sataranatarajan K, Watts L, Sabia M, Qi W, Van Remmen H. The effect of mild traumatic brain injury on peripheral nervous system pathology in wild-type mice and the G93A mutant mouse model of motor neuron disease. Neuroscience 298:410-423, 2015. [Abstract]

Evans TM, Van Remmen H, Purkar A, Mahesula S, Gelfond JA, Sabia M, Qi W, Lin AL, Jaramillo CA, Haskins WE. Microwave & Magnetic (M2) proteomics of a mouse model of mild traumatic brain injury. Transl Proteom 3:10-21, 2014. [Abstract]

Fernandes J, Weddle A, Kinter CS, Humphries KM, Mather T, Szweda LI, Kinter M. Lysine acetylation activates mitochondrial aconitase in the heart. Biochemistry 54:4008-4018, 2015. [Abstract]

Fu Y, Huebner JL, Kraus VB, Griffin TM. Effect of Aging on Adipose Tissue Inflammation in the Knee Joints of F344BN Rats. J Gerontol A Biol Sci Med Sci. 2015 Oct 8. pii: glv151. [Epub ahead of print] PMID: 26450946 [Abstract]

Fu, Y and Griffin, TM. (2015) Obesity, Osteoarthritis, and Aging: The Biomechanical Links. In: Stud Mechanobiol Tissue Eng Biomater. 16:181-201. Editors: Amit Gefen and Dafna Benayahu. Springer

Griffin TM, Humphries KM, Kinter M, Lim HY, Szweda LI. Nutrient sensing and utilization: Getting to the heart of metabolic flexibility. Biochimie. 2016 May;124:74-83. Epub 2015 Oct 22. Review. PMCID: PMC4828282 [Abstract]

Hofmann JW, Zhao X, De Cecco M., Peterson AL, Pagliaroli L, Manivannan J, Hubbard GB, Ikeno Y, Zhang Y, Feng B, Li X, Serre T, Qi W, Van Remmen H, Miller RA, Bath KG, de Cabo R., Xu H, Neretti N, Sedivy JM. Reduced expression of MYC increases longevity and enhances healthspan. Cell 160:477-488,2015. [Abstract]

Ivannikov MV, Van Remmen H. Sod1 ablation in adult mice leads to physiological changes at the neuromuscular junction similar to changes that occur in old wild type mice. Free Radic Biol Med 84:254-262,2015. [Abstract]

Kwak HB, Lee Y, Kim JH, Van Remmen H, Richardson AG, Lawler JM. MnSOD overexpression reduces fibrosis and pro-apoptotic signaling in the aging mouse heart. J Gerontol A Biol Sci Med Sci 70:533-544,2015. [Abstract]

Lane RS, Fu Y, Matsuzaki S, Kinter M, Humphries KM, Griffin TM. Mitochondrial respiration and redox coupling in articular chondrocytes. Arthritis Res Ther 17:54, 2015. [Abstract]

Matsuzaki S, Humphries KM. Selective inhibition of deactivated mitochondrial complex I by biguanides. Biochemistry 54:2011-2021, 2015. [Abstract]

Meyer RE, Chuong HH, Hild M, Hansen CL, Kinter M, Dawson DS. Ipl1/Aurora-B is necessary for kinetochore restructuring in meiosis I in Saccharomyces cerevisiae. Mol Biol Cell 26:2986-3000, 2015. [Abstract]

Plafker KS, Plafker SM. The ubiquitin conjugating enzyme, UBE2E3 and its import receptor, Importin-11 regulate the localization and activity of the anti-oxidant transcription factor NRF2. Mol Biol Cell 26:327-338, 2015. [Abstract]

Tsutsui Y, Johnson JM, Demeler B, Kinter M, Hays FA. Conformation-Dependent Human p52Shc Phosphorylation by Human c-Src. Biochemistry 54:3469-3482, 2015. [Abstract]

Walsh ME, Bhattacharya A, Sataranatarajan K, Qaisar R, Sloane L, Rahman MM, Kinter M, Van Remmen H. The histone deacetylase inhibitor butyrate improves metabolism and reduces muscle atrophy during aging. Aging Cell 2015. [Abstract] EPub

* Wiley MM, Muthukumar V, Griffin TM, Griffin CT. SWI/SNF Chromatin-Remodeling Enzymes Brahma-Related Gene 1 (BRG1) and Brahma (BRM) are dispensable in multiple models of postnatal angiogenesis but are required for vascular integrity in infant mice. J Am Heart Assoc 4: e001972, 2015. [Abstract]

Wong KE, Mikus CR, Slentz DH, Seiler SE, Debalsi KL, Ilkayeva OR, Crain KI, Kinter MT, Kien CL, Stevens RD, Muoio DM. Muscle-specific overexpression of PGC-1alpha does not augment metabolic improvements in response to exercise and caloric restriction. Diabetes 64:1532-1543, 2015. [Abstract]

Arthritis and Clinical Immunology Research Program

Aggarwal R, Anaya JM, Koelsch KA, Kurien BT, Scofield RH. Association between secondary and primary Sjogren’s syndrome in a large collection of lupus families. Autoimmune Dis 2015:298506, 2015. [Abstract]

Amaya-Amaya J, Rojas-Villarraga A, Molano-Gonzalez N, Montoya-Sanchez L, Nath SK, Anaya JM. GDF15(MIC1) H6D polymorphism does not influence cardiovascular disease in a Latin American population with rheumatoid arthritis. J Immunol Res 2015:270763, 2015. [Abstract]

Bourn R, James JA. Preclinical lupus. Curr Opin Rheumatol 27:433-439,2015. [Abstract]

* Buyon JP, Cohen P, Merrill JT, Gilkeson G, Kaplan M, James J, McCune WJ, Bernatsky S, Elkon K. A highlight from the LUPUS 2014 meeting: eight great ideas. Lupus Sci Med 2:e000087, 2015. [Abstract]

Canzler U, Bartsch H, Grossmann K, Lehmann W, Conrad K, Kurien BT, Dorri Y, Scofield RH, Bachmann MP. A miniaturized blotting system for simultaneous detection of different autoantibodies. Methods Mol Biol 1312:165-173, 2015. [Abstract]

Chakravarty EF, Martyanov V, Fiorentino D, Wood TA, Haddon DJ, Jarrell JA, Utz PJ, Genovese MC, Whitfield ML, Chung L. Gene expression changes reflect clinical response in a placebo-controlled randomized trial of abatacept in patients with diffuse cutaneous systemic sclerosis. Arthritis Res Ther 17:159, 2015. [Abstract]

Clark EG, Knoll G, Bugeja A, Burns KD, Scofield RH. Lupus after kidney donation to an affected male relative. Transplantation 99:e27-e28, 2015. [Abstract]

Coit P, Yalavarthi S, Ognenovski M, Zhao W, Hasni S, Wren JD, Kaplan MJ, Sawalha AH. Epigenome profiling reveals significant DNA demethylation of interferon signature genes in lupus neutrophils. J Autoimmun 58:59-66,2015. [Abstract]

Dao HD, Kota P, James JA, Stoner JA, Akins DR. Assessment of translational and interdisciplinary clinical research at an Oklahoma Health Sciences Center. J Okla State Med Assoc 108:93-101, 2015. [Abstract]

Demirci FY, Wang X, Kelly JA, Morris DL, Barmada MM, Feingold E, Kao AH, Sivils KL, Bernatsky S, Pineau C, Clarke A, Ramsey-Goldman R, Vyse TJ, Gaffney PM, Manzi S, Kamboh MI. Identification of a new susceptibility locus for systemic lupus erythematosus on Chromosome 12 in individuals of European ancestry. Arthritis Rheumatol 2015. [Abstract] EPub

* Edgar CE, Terrell DR, Vesely SK, Wren JD, Dozmorov IM, Niewold TB, Brown M, Zhou F, Frank MB, Merrill JT, Kremer Hovinga JA, Lammle B, James JA, George JN, Farris AD. Ribosomal and immune transcripts associate with relapse in acquired ADAMTS13-deficient thrombotic thrombocytopenic purpura. PLoS One 10:e0117614, 2015. [Abstract]

Fayyaz A, Igoe A, Kurien BT, Danda D, James JA, Stafford HA, Scofield RH. Haematological manifestations of lupus. Lupus Sci Med 2:e000078, 2015. [Abstract]

Fischer A, Ellinghaus D, Nutsua M, Hofmann S, Montgomery CG, Iannuzzi MC, Rybicki BA, Petrek M, Mrazek F, Pabst S, Grohe C, Grunewald J, Ronninger M, Eklund A, Padyukov L, Mihailovic-Vucinic V, Jovanovic D, Sterclova M, Homolka J, Nothen MM, Herms S, Gieger C, Strauch K, Winkelmann J, Boehm BO, Brand S, Buning C, Schurmann M, Ellinghaus E, Baurecht H, Lieb W, Nebel A, Muller-Quernheim J, Franke A, Schreiber S, GenPhenReSa Consortium. Identification of immune-relevant factors conferring sarcoidosis genetic risk. Am J Respir Crit Care Med 2015. [Abstract] EPub

G’sell RT, Gaffney PM, Powell DW. ABIN1 a physiological inhibitor of NF-kappaB: a molecular switch for inflammation and autoimmunity. Arthritis Rheumatol 67:2292-2302, 2015. [Abstract]

Gandhapudi SK, Tan C, Marino JH, Taylor AA, Pack CC, Gaikwad J, Van De Wiele CJ, Wren JD, Teague TK. IL-18 acts in synergy with IL-7 to promote ex vivo expansion of T lymphoid progenitor cells. J Immunol 194:3820-3828, 2015. [Abstract]

Gunther C, Kind B, Reijns MA, Berndt N, Martinez-Bueno M, Wolf C, Tungler V, Chara O, Lee YA, Hubner N, Bicknell L, Blum S, Krug C, Schmidt F, Kretschmer S, Koss S, Astell KR, Ramantani G, Bauerfeind A, Morris DL, Cunninghame Graham DS, Bubeck D, Leitch A, Ralston SH, Blackburn EA, Gahr M, Witte T, Vyse TJ, Melchers I, Mangold E, Nothen MM, Aringer M, Kuhn A, Luthke K, Unger L, Bley A, Lorenzi A, Isaacs JD, Alexopoulou D, Conrad K, Dahl A, Roers A, Alarcón-Riquelme ME, Jackson AP, Lee-Kirsch MA. Defective removal of ribonucleotides from DNA promotes systemic autoimmunity. J Clin Invest 125:413-424, 2015. [Abstract]

* Hanly JG, Su L, Urowitz MB, Romero-Diaz J, Gordon C, Bae SC, Bernatsky S, Clarke AE, Wallace DJ, Merrill JT, Isenberg DA, Rahman A, Ginzler EM, Petri M, Bruce IN, Dooley MA, Fortin P, Gladman DD, Sanchez-Guerrero J, Steinsson K, Ramsey-Goldman R, Khamashta MA, Aranow C, Alarcon GS, Fessler BJ, Manzi S, Nived O, Sturfelt GK, Zoma AA, Van Vollenhoven RF, Ramos-Casals M, Ruiz-Irastorza G, Sam Lim S, Kalunian KC, Inanc M, Kamen DL, Peschken CA, Jacobsen S, Askanase A, Theriault C, Thompson K, Farewell V. Mood disorders in systemic lupus erythematosus: Results from an international, inception cohort study. Arthritis Rheumatol 67:1837-1847, 2015. [Abstract]

Herlea-Pana O, Yao L, Heuser-Baker J, Wang Q, Wang Q, Georgescu C, Zou MH, Barlic-Dicen J. Chemokine receptors CXCR2 and CX3CR1 differentially regulate functional responses of bone-marrow endothelial progenitors during atherosclerotic plaque regression. Cardiovasc Res. 2015 May 1;106(2):324-37. [Abstract]

Hofmann-Apitius M, Alarcon-Riquelme ME, Chamberlain C, McHale D. Towards the taxonomy of human disease. Nat Rev Drug Discov 14:75-76, 2015. [Abstract]

Isenberg D, Gordon C, Licu D, Copt S, Rossi CP, Wofsy D. Efficacy and safety of Atacicept for prevention of flares in patients with moderate-to-severe systemic lupus erythematosus (SLE): 52-week data (APRIL-SLE randomised trial). Ann Rheum Dis 2015. [Abstract] EPub (Chakravarty, E. – collaborator)

* Iwayama T, Steele C, Yao L, Dozmorov MG, Karamichos D, Wren JD, Olson LE. PDGFRalpha signaling drives adipose tissue fibrosis by targeting progenitor cell plasticity. Genes Dev 29:1106-1119, 2015. [Abstract]

* James JA, Thompson LF, Budd RC. J. Donald Capra, M.D. (1937-2015). J Immunol 194:5575-5576, 2015. [Abstract]

Kariuki SN, Ghodke-Puranik Y, Dorschner JM, Chrabot BS, Kelly JA, Tsao BP, Kimberly RP, Alarcón-Riquelme ME, Jacob CO, Criswell LA, Sivils KL, Langefeld CD, Harley JB, Skol AD, Niewold TB. Genetic analysis of the pathogenic molecular sub-phenotype interferon-alpha identifies multiple novel loci involved in systemic lupus erythematosus. Genes Immun 16:15-23, 2015. [Abstract]

Kattah NH, Newell EW, Jarrell JA, Chu AD, Xie J, Kattah MG, Goldberger O, Ye J, Chakravarty EF, Davis MM, Utz PJ. Tetramers reveal IL-17-secreting CD4+ T cells that are specific for U1-70 in lupus and mixed connective tissue disease. Proc Natl Acad Sci U S A 112:3044-3049, 2015. [Abstract]

Kaur K, Zheng NY, Smith K, Huang M, Li L, Pauli NT, Henry Dunand CJ, Lee JH, Morrissey M, Wu Y, Joachims ML, Munroe ME, Lau D, Qu X, Krammer F, Wrammert J, Palese P, Ahmed R, James JA, Wilson PC. High affinity antibodies against influenza characterize the plasmablast response in SLE patients after vaccination. PLoS One 10:e0125618, 2015. [Abstract]

Kavanaugh A, Cush JJ, Ahmed MS, Bermas BL, Chakravarty E, Chambers C, Clowse M, Curtis JR, Dao K, Hankins GD, Koren G, Kim SC, Lapteva L, Mahadevan U, Moore T, Nolan M, Ren Z, Sammaritano LR, Seymour S, Weisman MH. Proceedings from the American College of Rheumatology Reproductive Health Summit: The management of fertility, pregnancy and lactation in women with autoimmune and systemic inflammatory diseases. Arthritis Care Res (Hoboken) 67:313-325, 2015. [Abstract]

Kim K, Bang SY, Lee HS, Cho SK, Choi CB, Sung YK, Kim TH, Jun JB, Yoo DH, Kang YM, Kim SK, Suh CH, Shim SC, Lee SS, Lee J, Chung WT, Choe JY, Shin HD, Lee JY, Han BG, Nath SK, Eyre S, Bowes J, Pappas DA, Kremer JM, Gonzalez-Gay MA, Rodriguez-Rodriguez L, Arlestig L, Okada Y, Diogo D, Liao KP, Karlson EW, Raychaudhuri S, Rantapaa-Dahlqvist S, Martin J, Klareskog L, Padyukov L, Gregersen PK, Worthington J, Greenberg JD, Plenge RM, Bae SC. High-density genotyping of immune loci in Koreans and Europeans identifies eight new rheumatoid arthritis risk loci. Ann Rheum Dis 74:e13, 2015. [Abstract]

* Kottyan LC, Zoller EE, Bene J, Lu X, Kelly JA, Rupert AM, Lessard CJ, Vaughn SE, Marion M, Weirauch MT, Namjou B, Adler A, Rasmussen A, Glenn S, Montgomery CG, Hirschfield GM, Xie G, Coltescu C, Amos C, Li H, Ice JA, Nath SK, Mariette X, Simon Bowman for UK primary Sjogren’s syndrome registry, Rischmueller M, Lester S, Brun JG, Goransson LG, Harboe E, Omdal R, Cunninghame-Graham DS, Vyse T, Miceli-Richard C, Brennan MT, Lessard JA, Wahren-Herlenius M, Kvarnstrom M, Illei GG, Witte T, Jonsson R, Eriksson P, Nordmark G, Wan-Fai Ng for UK primary Sjogren’s syndrome registry, Anaya JM, Rhodus NL, Segal BM, Merrill JT, James JA, Guthridge JM, Scofield RH, Alarcón-Riquelme M, Bae SC, Boackle SA, Criswell LA, Gilkeson G, Kamen DL, Jacob CO, Kimberly R, Brown E, Edberg J, Alarcon GS, Reveille JD, Vila LM, Petri M, Ramsey-Goldman R, Freedman BI, Niewold T, Stevens AM, Tsao BP, Ying J, Mayes MD, Gorlova OY, Wakeland W, Radstake T, Martin E, Martin J, Siminovitch K, Moser Sivils KL, Gaffney PM, Langefeld CD, Harley JB, Kaufman KM. The IRF5-TNPO3 association with systemic lupus erythematosus (SLE) has two components that other autoimmune disorders variably share. Hum Mol Genet 24:582-596, 2015. [Abstract]

Kovats S. Estrogen receptors regulate innate immune cells and signaling pathways. Cell Immunol 294:63-69,2015. [Abstract]

Kurien BT, Danda D, Scofield RH. Fingerprint deposition on nitrocellulose and polyvinylidene difluoride membranes using alkaline phosphatase. Methods Mol Biol 1312:481-485, 2015. [Abstract]

Kurien BT, Danda D, Scofield RH. Therapeutic potential of curcumin and curcumin analogues in rheumatology. Int J Rheum Dis 18:591-593, 2015. [Abstract]

Kurien BT, Danda D, Bachmann MP, Scofield RH. SDS-PAGE to Immunoblot in One Hour. Methods Mol Biol 1312:449-454, 2015. [Abstract]

Kurien BT, Scofield RH. Analysis of antibody clonotype by affinity immunoblotting. Methods Mol Biol 1312:109-117, 2015. [Abstract]

Kurien BT, Scofield RH. Multiple Immunoblots by Passive Diffusion of Proteins from a Single SDS-PAGE Gel. Methods Mol Biol 1312:77-86, 2015. [Abstract]

Kurien BT, Scofield RH. Other notable protein blotting methods: a brief review. Methods Mol Biol 1312:487-503, 2015. [Abstract]

Kurien BT, Scofield RH. Western blotting: an introduction. Methods Mol Biol 1312:17-30, 2015. [Abstract]

Kurien BT, Scofield RH. Western blotting of high and low molecular weight proteins using heat. Methods Mol Biol 1312:247-255, 2015. [Abstract]

Levin AM, Adrianto I, Datta I, Iannuzzi MC, Trudeau S, Drake WP, Li J, Montgomery CG, Rybicki BA. Association of HLA-DRB1 with Sarcoidosis susceptibility and progression in African Americans. Am J Respir Cell Mol Biol 53:206-216,2015. [Abstract]

Lu X, Zoller EE, Weirauch MT, Wu Z, Namjou B, Williams AH, Ziegler JT, Comeau ME, Marion MC, Glenn SB, Adler A, Shen N, Nath SK, Stevens AM, Freedman BI, Tsao BP, Jacob CO, Kamen DL, Brown EE, Gilkeson GS, Alarcon GS, Reveille JD, Anaya JM, James JA, Sivils KL, Criswell LA, Vila LM, Alarcon-Riquelme ME, Petri M, Scofield RH, Kimberly RP, Ramsey-Goldman R, Joo YB, Choi J, Bae SC, Boackle SA, Graham DC, Vyse TJ, Guthridge JM, Gaffney PM, Langefeld CD, Kelly JA, Greis KD, Kaufman KM, Harley JB, Kottyan LC. Lupus risk variant increases pSTAT1 binding and decreases ETS1 expression. Am J Hum Genet 96:731-739, 2015. [Abstract]

Maier-Moore JS, Kurien BT, D’Souza A, Bockus L, Asfa S, Dorri Y, Hubbell S, Yeliosof O, Obeso D, Schoeb TR, Jonsson R, Scofield RH. Passive transfer of antibodies to the linear epitope 60 kD Ro 273-289 induces features of Sjogren’s syndrome in naive mice. Clin Exp Immunol 180:19-27,2015. [Abstract]

* Martins M, Williams AH, Comeau M, Marion M, Ziegler JT, Freedman BI, Merrill JT, Glenn SB, Kelly JA, Sivils KM, James JA, Guthridge JM, Alarcon-Riquelme ME, Bae S, Kim J, Kim D, Anaya J, Boackle SA, Criswell LA, Kimberly RP, Alarcon GS, Brown EE, Vila LM, Petri MA, Ramsey-Goldman R, Niewold TB, Tsao BP, Gilkeson GS, Kamen DL, Jacob CO, Stevens AM, Gaffney PM, Harley JB, Langefeld CD, Fesel C. Genetic association of CD247 (CD3zeta) with SLE in a large-scale multiethnic study. Genes Immun 16:142-150, 2015. [Abstract]

Miller DH, Fox RJ, Phillips JT, Hutchinson M, Havrdova E, Kita M, Wheeler-Kingshott CA, Tozer DJ, MacManus DG, Yousry TA, Goodsell M, Yang M, Zhang R, Viglietta V, Dawson KT, For the CONFIRM study investigators. Effects of delayed-release dimethyl fumarate on MRI measures in the phase 3 CONFIRM study. Neurology 84:1145-1152,2015. [Abstract] (Pardo collaborator)

Obregon-Tito AJ, Tito RY, Metcalf J, Sankaranarayanan K, Clemente JC, Ursell LK, Zech XZ, Van TW, Knight R, Gaffney PM, Spicer P, Lawson P, Marin-Reyes L, Trujillo-Villarroel O, Foster M, Guija-Poma E, Troncoso-Corzo L, Warinner C, Ozga AT, Lewis CM. Subsistence strategies in traditional societies distinguish gut microbiomes. Nat Commun 6:6505, 2015. [Abstract]

Oparina NY, Delgado-Vega AM, Martinez-Bueno M, Magro-Checa C, Fernandez C, Castro RO, Pons-Estel BA, D’Alfonso S, Sebastiani GD, Witte T, Lauwerys BR, Endreffy E, Kovacs L, Escudero A, Lopez-Pedrera C, Vasconcelos C, da Silva BM, Frostegard J, Truedsson L, Martin J, Raya E, Ortego-Centeno N, de Los Angeles AM, de Ramon GE, Palma MJ, Alarcón-Riquelme ME, Kozyrev SV. PXK locus in systemic lupus erythematosus: fine mapping and functional analysis reveals novel susceptibility gene ABHD6. Ann Rheum Dis 74:e14, 2015. [Abstract]

Pons-Estel GJ, Catoggio LJ, Cardiel MH, Bonfa E, Caeiro F, Sato E, Massardo L, Molina-Restrepo JF, Toledano MG, Barile-Fabris LA, Amigo MC, Acevedo-Vasquez EM, Abadi I, Wojdyla D, Alarcon-Riquelme ME, Alarcon GS, Pons-Estel BA. Lupus in Latin-American patients: lessons from the GLADEL cohort. Lupus 24:535-545, 2015.[Abstract]

* Ratliff ML, Ward JM, Merrill JT, James JA, Webb CF. Differential expression of the transcription factor ARID3a in lupus patient hematopoietic progenitor cells. J Immunol 194:940-949, 2015. [Abstract]

Renauer P, Saruhan-Direskeneli G, Coit P, Adler A, Aksu K, Keser G, Alibaz-Oner F, Aydin SZ, Kamali S, Inanc M, Carette S, Cuthbertson D, Hoffman GS, Akar S, Onen F, Akkoc N, Khalidi NA, Koening C, Karadag O, Kiraz S, Langford CA, Maksimowicz-McKinnon K, McAlear CA, Ozbalkan Z, Ates A, Karaaslan Y, Duzgun N, Monach PA, Ozer HT, Erken E, Ozturk MA, Yazici A, Cefle A, Onat AM, Kisacik B, Pagnoux C, Kasifoglu T, Seyahi E, Fresko I, Seo P, Sreih A, Warrington KJ, Ytterberg SR, Cobankara V, Cunninghame-Graham DS, Vyse TJ, Pamuk ON, Tunc E, Dalkilic E, Bicakcigil M, Yentur SP, Wren JD, Merkel PA, Direskeneli H, Sawalha AH. Genome-wide association study identifies susceptibility loci in IL6, RPS9/LILRB3, and an intergenic locus on chromosome 21q22 in Takayasu’s arteritis. Arthritis Rheumatol 2015. [Abstract]

Sandhya P, Jeyaseelan L, Scofield RH, Danda D. Clinical characteristics and outcome of primary Sjogren’s syndrome: A large Asian Indian cohort. Open Rheumatol J 9:36-45, 2015. [Abstract]

Schaffert SA, Loh C, Wang S, Arnold CP, Axtell RC, Newell EW, Nolan G, Ansel KM, Davis MM, Steinman L, Chen CZ. mir-181a-1/b-1 Modulates tolerance through opposing activities in selection and peripheral T cell function. J Immunol 195:1470-1479, 2015. [Abstract]

Schubert RD, Hu Y, Kumar G, Szeto S, Abraham P, Winderl J, Guthridge JM, Pardo G, Dunn J, Steinman L, Axtell RC. IFN-beta Treatment Requires B Cells for Efficacy in Neuroautoimmunity. J Immunol 194:2110-2116,2015. [Abstract]

Segan J, Staples MP, March L, Lassere M, Chakravarty EF, Buchbinder R. Risk factors for herpes zoster in rheumatoid arthritis patients: The role of tumor necrosis factor alpha inhibitors. Intern Med J 45:310-318,2015. [Abstract]

Seror R, Bootsma H, Saraux A, Bowman SJ, Theander E, Brun JG, Baron G, Le Guern V, Devauchelle-Pensec V, Ramos-Casals M, Valim V, Dorner T, Tzioufas A, Gottenberg JE, Solans LR, Mandl T, Hachulla E, Sivils KL, Ng WF, Fauchais AL, Bombardieri S, Priori R, Bartoloni E, Goeb V, Praprotnik S, Sumida T, Nishiyama S, Caporali R, Kruize AA, Vollenweider C, Ravaud P, Meiners P, Brito-Zeron P, Vitali C, Mariette X, on behalf of the EULAR Sjogren’s Task Force. Defining disease activity states and clinically meaningful improvement in primary Sjogren’s syndrome with EULAR primary Sjogren’s syndrome disease activity (ESSDAI) and patient-reported indexes (ESSPRI). Ann Rheum Dis 2015. [Abstract] EPub

Seror R, Theander E, Brun JG, Ramos-Casals M, Valim V, Dorner T, Bootsma H, Tzioufas A, Solans-Laque R, Mandl T, Gottenberg JE, Hachulla E, Sivils KL, Ng WF, Fauchais AL, Bombardieri S, Valesini G, Bartoloni E, Saraux A, Tomsic M, Sumida T, Nishiyama S, Caporali R, Kruize AA, Vollenweider C, Ravaud P, Vitali C, Mariette X, Bowman SJ, on behalf of the EULAR Sjogren’s Task Force. Validation of EULAR primary Sjogren’s syndrome disease activity (ESSDAI) and patient indexes (ESSPRI). Ann Rheum Dis 74:859-866,2015. [Abstract]

Shen L, Zhang H, Caimol M, Benike CJ, Chakravarty EF, Strober S, Engleman EG. Invariant natural killer T cells in lupus patients promote IgG and IgG autoantibody production. Eur J Immunol 45:612-623, 2015. [Abstract]

Slight-Webb SR, Bagavant H, Crowe SR, James JA. Influenza A (H1N1) virus infection triggers severe pulmonary inflammation in lupus-prone mice following viral clearance. J Autoimmun 57:66-67,2015. [Abstract]

Szczerba BM, Kaplonek P, Wolska N, Podsiadlowska A, Rybakowska PD, Dey P, Rasmussen A, Grundahl K, Hefner KS, Stone DU, Young S, Lewis DM, Radfar L, Scofield RH, Sivils KL, Bagavant H, Deshmukh US. Interaction between innate immunity and Ro52-induced antibody causes Sjogren’s syndrome-like disorder in mice. Ann Rheum Dis 2015. [Abstract] EPub

Toth P, Tarantini S, Springo Z, Tucsek Z, Gautam T, Giles CB, Wren JD, Koller A, Sonntag WE, Csiszar A, Ungvari Z. Aging exacerbates hypertension-induced cerebral microhemorrhages in mice: role of resveratrol treatment in vasoprotection. Aging Cell 14:400-408, 2015. [Abstract]

Trieu EP, Targoff IN. Immunoprecipitation: Western blot for proteins of low abundance. Methods Mol Biol 1312:327-342, 2015. [Abstract]

Tulunay A, Dozmorov MG, Ture-Ozdemir F, Yilmaz V, Eksioglu-Demiralp E, Alibaz-Oner F, Ozen G, Wren JD, Saruhan-Direskeneli G, Sawalha AH, Direskeneli H. Activation of the JAK/STAT pathway in Behcet’s disease. Genes Immun 16:170-175, 2015. [Abstract]

Vaughn SE, Foley C, Lu X, Patel ZH, Zoller EE, Magnusen AF, Williams AH, Ziegler JT, Comeau ME, Marion MC, Glenn SB, Adler A, Shen N, Nath S, Stevens AM, Freedman BI, Tsao BP, Jacob CO, Kamen DL, Brown EE, Gilkeson GS, Alarcon GS, Reveille JD, Anaya JM, James JA, Moser KL, Criswell LA, Vila LM, Alarcon-Riquelme ME, Petri M, Scofield RH, Kimberly RP, Ramsey-Goldman R, Binjoo Y, Choi J, Bae SC, Boackle SA, Vyse TJ, Guthridge JM, Namjou B, Gaffney PM, Langefeld CD, Kaufman KM, Kelly JA, Harley IT, Harley JB, Kottyan LC. Lupus risk variants in the PXK locus alter B-cell receptor internalization. Front Genet 5:450, 2014. [Abstract]

Vuckovic F, Kristic J, Gudelj I, Teruel AM, Keser T, Pezer M, Pucic-Bakovic M, Stambuk J, Trbojevic-Akmacic I, Barrios C, Pavic T, Menni C, Wang Y, Zhou Y, Cui L, Song H, Zeng Q, Guo X, Pons-Estel BA, McKeigue P, Patrick AL, Gornik O, Spector TD, Harjacek M, Alarcon-Riquelme M, Molokhia M, Wang W, Lauc G. Systemic lupus erythematosus associates with the decreased immunosuppressive potential of the IgG glycome. Arthritis Rheumatol 2015. [Abstract] EPub

Wang S, Wiley GB, Kelly JA, Gaffney PM. Disease mechanisms in rheumatology–tools and pathways: defining functional genetic variants in autoimmune diseases. Arthritis Rheumatol 67:1-10, 2015. [Abstract]

Wu YY, Georg I, Diaz-Barreiro A, Varela N, Lauwerys B, Kumar R, Bagavant H, Castillo-Martin M, El Salem F, Maranon C, Alarcon-Riquelme ME. Concordance of increased B1 cell subset and lupus phenotypes in mice and humans is dependent on BLK expression levels. J Immunol 194:5692-5702, 2015. [Abstract]

Yaciuk JC, Pan Y, Schwarz K, Pan ZJ, Maier-Moore JS, Kosanke SD, Lawrence C, Farris AD. Defective selection of thymic regulatory T cells accompanies autoimmunity and pulmonary infiltrates in Tcra-deficient mice double transgenic for human La/Sjogren’s syndrome-B and human La-specific TCR. J Immunol 194:1514-1522,2015. [Abstract]

Yapundich R, Applebee A, Bethoux F, Goldman MD, Hutton GJ, Mass M, Pardo G, Klingler M, Henney HR, III, Blight AR, Carrazana EJ. Evaluation of Dalfampridine extended release 5 and 10 mg in multiple sclerosis: A randomized controlled trial. Int J MS Care 17:138-145, 2015. [Abstract]

Yeliosof O, Scofield RH. Grid-immunoblotting. Methods Mol Biol 1312:375-378, 2015. [Abstract]

* Zhao J, Giles BM, Taylor RL, Yette GA, Lough KM, Ng HL, Abraham LJ, Wu H, Kelly JA, Glenn SB, Adler AJ, Williams AH, Comeau ME, Ziegler JT, Marion M, Alarcón-Riquelme ME, Alarcon GS, Anaya JM, Bae SC, Kim D, Lee HS, Criswell LA, Freedman BI, Gilkeson GS, Guthridge JM, Jacob CO, James JA, Kamen DL, Merrill JT, Sivils KM, Niewold TB, Petri MA, Ramsey-Goldman R, Reveille JD, Scofield RH, Stevens AM, Vila LM, Vyse TJ, Kaufman KM, Harley JB, Langefeld CD, Gaffney PM, Brown EE, Edberg JC, Kimberly RP, Ulgiati D, Tsao BP, Boackle SA, for the BIOLUPUS and GENLES Networks. Preferential association of a functional variant in complement receptor 2 with antibodies to double-stranded DNA. Ann Rheum Dis 2015. [Abstract] EPub

Zhou XJ, Mu R, Li C, Nath SK, Zhang YM, Qi YY, Li ZG, Zhao MH, Zhang H. Variants in CCR6 are associated with susceptibility to lupus nephritis in Chinese. Arthritis Rheumatol 2015. [Abstract]

Zhu Y, Tchkonia T, Pirtskhalava T, Gower A, Ding H, Giorgadze N, Palmer AK, Ikeno Y, Borden G, Lenburg M, O’Hara SP, LaRusso NF, Miller JD, Roos CM, Verzosa GC, LeBrasseur NK, Wren JD, Farr JN, Khosla S, Stout MB, McGowan SJ, Fuhrmann-Stroissnigg H, Gurkar AU, Zhao J, Colangelo D, Dorronsoro A, Ling YY, Barghouthy AS, Navarro DC, Sano T, Robbins PD, Niedernhofer LJ, Kirkland JL. The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs. Aging Cell 14:644-658,2015. [Abstract]

Cardiovascular Biology Research Program

Astarita JL, Cremasco V, Fu J, Darnell MC, Peck JR, Nieves-Bonilla JM, Song K, Kondo Y, Woodruff MC, Gogineni A, Onder L, Ludewig B, Weimer RM, Carroll MC, Mooney DJ, Xia L, Turley SJ. The CLEC-2-podoplanin axis controls the contractility of fibroblastic reticular cells and lymph node microarchitecture. Nat Immunol 16:75-84, 2015. [Abstract]

Chaaban H, Keshari RS, Silasi-Mansat R, Popescu NI, Mehta-D’souza P, Lim YP, Lupu F. Inter-alpha inhibitor protein and its associated glycosaminoglycans protect against histone-induced injury. Blood 125:2286-2296,2015. [Abstract]

Chang B, Tessneer KL, McManus J, Liu X, Hahn S, Pasula S, Wu H, Song H, Chen Y, Cai X, Dong Y, Brophy ML, Rahman R, Ma JX, Xia L, Chen H. Epsin is required for Dishevelled stability and Wnt signalling activation in colon cancer development. Nat Commun 6:6380, 2015. [Abstract]

De Souza PC, Smith N, Pody R, He T, Njoku C, Silasi-Mansat R, Lupu F, Meek B, Chen H, Dong Y, Saunders D, Orock A, Hodges E, Colijn S, Mamedova N, Towner RA. OKN-007 decreases VEGFR-2 levels in a preclinical GL261 mouse glioma model. Am J Nucl Med Mol Imaging 5:363-378, 2015. [Abstract]

*Dong Y, Wu H, Rahman HN, Liu Y, Pasula S, Tessneer KL, Cai X, Liu X, Chang B, McManus J, Hahn S, Dong J, Brophy ML, Yu L, Song K, Silasi-Mansat R, Saunders D, Njoku C, Song H, Mehta-D’Souza P, Towner R, Lupu F, McEver RP, Xia L, Boerboom D, Srinivasan RS, Chen H. Motif mimetic of epsin perturbs tumor growth and metastasis. J Clin Invest. 2015 Dec;125(12):4349-64. [Abstract] Epub 2015 Nov 16. PMCID: PMC4665789

* He C, Medley SC, Hu T, Hinsdale ME, Lupu F, Virmani R, Olson LE. PDGFRbeta signalling regulates local inflammation and synergizes with hypercholesterolaemia to promote atherosclerosis. Nat Commun 6:7770, 2015. [Abstract]

Herlea-Pana O, Yao L, Heuser-Baker J, Wang Q, Wang Q, Georgescu C, Zou MH, Barlic-Dicen J. Chemokine receptors CXCR2 and CX3CR1 differentially regulate functional responses of bone marrow endothelial progenitors during atherosclerotic plaque regression. Cardiovasc Res 106:324-337, 2015.[Abstract]

Jackson KW, Christiansen VJ, Yadav VR, Silasi-Mansat R, Lupu F, Awasthi V, Zhang RR, McKee PA. Suppression of tumor growth in mice by rationally designed pseudopeptide inhibitors of fibroblast activation protein and prolyl oligopeptidase. Neoplasia 17:43-54, 2015. [Abstract]

Mastellos DC, Yancopoulou D, Kokkinos P, Huber-Lang M, Hajishengallis G, Biglarnia AR, Lupu F, Nilsson B, Risitano AM, Ricklin D, Lambris JD. Compstatin: a C3-targeted complement inhibitor reaching its prime for bedside intervention. Eur J Clin Invest 45:423-440,2015. [Abstract]

McEver RP. Selectins: initiators of leukocyte adhesion and signaling at the vascular wall. Cardiovasc Res 107:331-339,2015. [Abstract]

Pruenster M, Kurz AR, Chung KJ, Cao-Ehlker X, Bieber S, Nussbaum CF, Bierschenk S, Eggersmann TK, Rohwedder I, Heinig K, Immler R, Moser M, Koedel U, Gran S, McEver RP, Vestweber D, Verschoor A, Leanderson T, Chavakis T, Roth J, Vogl T, Sperandio M. Extracellular MRP8/14 is a regulator of beta2 integrin-dependent neutrophil slow rolling and adhesion. Nat Commun 6:6915, 2015. [Abstract]

Shao B, Yago T, Setiadi H, Wang Y, Mehta-D’souza P, Fu J, Crocker PR, Rodgers W, Xia L, McEver RP. O-glycans direct selectin ligands to lipid rafts on leukocytes. Proc Natl Acad Sci U S A 112:8661-8666,2015. [Abstract]

Song K, Herzog BH, Fu J, Sheng M, Bergstrom K, McDaniel JM, Kondo Y, McGee S, Cai X, Li P, Chen H, Xia L. Loss of core 1-derived O-glycans decreases breast cancer development in mice. J Biol Chem 290:20159-20166, 2015. [Abstract]

Yago T, Petrich BG, Zhang N, Liu Z, Shao B, Ginsberg MH, McEver RP. Blocking neutrophil integrin activation prevents ischemia-reperfusion injury. J Exp Med 212:1267-1281, 2015. [Abstract]

Yan R, Chen M, Ma N, Zhao L, Cao L, Zhang Y, Zhang J, Yu Z, Wang Z, Xia L, Ruan C, Dai K. Glycoprotein Ibalpha clustering induces macrophage-mediated platelet clearance in the liver. Thromb Haemost 113:107-117, 2015. [Abstract]

Cell Cycle and Cancer Biology Research Program

Gorbsky GJ. The spindle checkpoint and chromosome segregation in meiosis. FEBS J 282:2458-2474,2015. [Abstract]

Kurdzo EL, Dawson DS. Centromere pairing – tethering partner chromosomes in meiosis I. FEBS J 282:2445-2457,2015. [Abstract]

Lee CY, Horn HF, Stewart CL, Burke B, Bolcun-Filas E, Schimenti JC, Dresser ME, Pezza RJ. Mechanism and regulation of rapid telomere prophase movements in mouse meiotic chromosomes. Cell Rep 11:551-563,2015. [Abstract]

Pezza RJ. Mechanisms of chromosome segregation in meiosis: new views on the old problem of aneuploidy. FEBS J 282:2411-2412,2015. [Abstract]

Rankin S. Complex elaboration: making sense of meiotic cohesin dynamics. FEBS J 282:2413-2430,2015. [Abstract]

Sansam CL, Pezza RJ. Connecting by breaking and repairing: mechanisms of DNA strand exchange in meiotic recombination. FEBS J 282:2431-2444,2015. [Abstract]

Sansam CG, Goins D, Siefert JC, Clowdus EA, Sansam CL. Cyclin-dependent kinase regulates the length of S phase through TICRR/TRESLIN phosphorylation. Genes Dev 29:555-566, 2015. [Abstract]

Sivakumar S, Gorbsky GJ. Spatiotemporal regulation of the anaphase-promoting complex in mitosis. Nat Rev Mol Cell Biol 16:82-94,2015. [Abstract]

Clinical Pharmacology Research Program

Askanase A, Li X, Pong A, Shum K, Kamp S, Carthen F, Aberle T, Hanrahan L, Daly P, Giles J, Merrill JT. Preliminary test of the LFA rapid evaluation of activity in lupus (LFA-REAL): an efficient outcome measure correlates with validated instruments. Lupus Sci Med 2:e000075, 2015. [Abstract]

Bourre-Tessier J, Urowitz MB, Clarke AE, Bernatsky S, Krantz MJ, Huynh T, Joseph L, Belisle P, Bae SC, Hanly JG, Wallace DJ, Gordon C, Isenberg D, Rahman A, Gladman DD, Fortin PR, Merrill JT, Romero-Diaz J, Sanchez-Guerrero J, Fessler B, Alarcon GS, Steinsson K, Bruce IN, Ginzler E, Dooley MA, Nived O, Sturfelt G, Kalunian K, Ramos-Casals M, Petri M, Zoma A, Pineau CA. Electrocardiographic findings in systemic lupus erythematosus: Data from an international inception cohort. Arthritis Care Res (Hoboken) 67:128-135, 2015. [Abstract]

Bruce IN, O’Keeffe AG, Farewell V, Hanly JG, Manzi S, Su L, Gladman DD, Bae SC, Sanchez-Guerrero J, Romero-Diaz J, Gordon C, Wallace DJ, Clarke AE, Bernatsky S, Ginzler EM, Isenberg DA, Rahman A, Merrill JT, Alarcon GS, Fessler BJ, Fortin PR, Petri M, Steinsson K, Dooley MA, Khamashta MA, Ramsey-Goldman R, Zoma AA, Sturfelt GK, Nived O, Aranow C, Mackay M, Ramos-Casals M, Van Vollenhoven RF, Kalunian KC, Ruiz-Irastorza G, Lim S, Kamen DL, Peschken CA, Inanc M, Urowitz MB. Factors associated with damage accrual in patients with systemic lupus erythematosus: results from the Systemic Lupus International Collaborating Clinics (SLICC) Inception Cohort. Ann Rheum Dis 74:1706-1713, 2015. [Abstract]

* Buyon JP, Cohen P, Merrill JT, Gilkeson G, Kaplan M, James J, McCune WJ, Bernatsky S, Elkon K. A highlight from the LUPUS 2014 meeting: eight great ideas. Lupus Sci Med 2:e000087, 2015. [Abstract]

Buyon JP, Kim MY, Guerra MM, Laskin CA, Petri M, Lockshin MD, Sammaritano L, Branch DW, Porter TF, Sawitzke A, Merrill JT, Stephenson MD, Cohn E, Garabet L, Salmon JE. Predictors of pregnancy outcomes in patients with lupus: a cohort study. Ann Intern Med 163:153-163,2015. [Abstract]

Coit P, Renauer P, Jeffries MA, Merrill JT, McCune WJ, Maksimowicz-McKinnon K, Sawalha AH. Renal involvement in lupus is characterized by unique DNA methylation changes in naive CD4+ T cells. J Autoimmun 61:29-35,2015. [Abstract]

Kalunian KC, Merrill JT, Maciuca R, McBride JM, Townsend MJ, Wei X, Davis JC, Jr., Kennedy WP. A Phase II study of the efficacy and safety of rontalizumab (rhuMAb interferon-alpha) in patients with systemic lupus erythematosus (ROSE). Ann Rheum Dis 2015. [Abstract] EPub

Merrill JT. Connective tissue diseases: Is SLE many single-organ diseases or an overlapping spectrum? Nat Rev Rheumatol 11:385-386,2015. [Abstract]

Merrill JT, Van Vollenhoven RF, Buyon JP, Furie RA, Stohl W, Morgan-Cox M, Dickson C, Anderson PW, Lee C, Berclaz PY, Dorner T. Efficacy and safety of subcutaneous tabalumab, a monoclonal antibody to B-cell activating factor, in patients with systemic lupus erythematosus: results from ILLUMINATE-2, a 52-week, phase III, multicentre, randomised, double-blind, placebo-controlled study. Ann Rheum Dis 2015. [Abstract] EPub

Orbai AM, Truedsson L, Sturfelt G, Nived O, Fang H, Alarcon G, Gordon C, Merrill J, Fortin P, Bruce I, Isenberg D, Wallace D, Ramsey-Goldman R, Bae SC, Hanly J, Sanchez-Guerrero J, Clarke A, Aranow C, Manzi S, Urowitz M, Gladman D, Kalunian K, Costner M, Werth V, Zoma A, Bernatsky S, Ruiz-Irastorza G, Khamashta M, Jacobsen S, Buyon J, Maddison P, Dooley M, Van Vollenhoven R., Ginzler E, Stoll T, Peschken C, Jorizzo J, Callen J, Lim S, Fessler B, Inanc M, Kamen D, Rahman A, Steinsson K, Franks A, Jr., Sigler L, Hameed S, Pham N, Brey R, Weisman M, McGwin G, Jr., Magder L, Petri M. Anti-C1q antibodies in systemic lupus erythematosus. Lupus 24:42-49, 2015. [Abstract]

Parker B, Urowitz MB, Gladman DD, Lunt M, Donn R, Bae SC, Sanchez-Guerrero J, Romero-Diaz J, Gordon C, Wallace DJ, Clarke AE, Bernatsky S, Ginzler EM, Isenberg DA, Rahman A, Merrill JT, Alarcon GS, Fessler BJ, Fortin PR, Hanly JG, Petri M, Steinsson K, Dooley MA, Manzi S, Khamashta MA, Ramsey-Goldman R, Zoma AA, Sturfelt GK, Nived O, Aranow C, Mackay M, Ramos-Casals M, Van Vollenhoven RF, Kalunian KC, Ruiz-Irastorza G, Lim SS, Kamen DL, Peschken CA, Inanc M, Bruce IN. Impact of early disease factors on metabolic syndrome in systemic lupus erythematosus: data from an international inception cohort. Ann Rheum Dis 74:1530-1536,2015. [Abstract]

Stohl W, Merrill JT, Looney RJ, Buyon J, Wallace DJ, Weisman MH, Ginzler EM, Cooke B, Holloway D, Kaliyaperumal A, Kuchimanchi KR, Cheah TC, Rasmussen E, Ferbas J, Belouski SS, Tsuji W, Zack DJ. Treatment of systemic lupus erythematosus patients with the BAFF antagonist “peptibody” blisibimod (AMG 623/A-623): results from randomized, double-blind phase 1a and phase 1b trials. Arthritis Res Ther 17:215, 2015. [Abstract]

Wallace DJ, Hobbs K, Clowse ME, Petri M, Strand V, Pike M, Merrill JT, Leszczynski P, Neuwelt CM, Jeka S, Houssiau F, Keiserman M, Ordi-Ros J, Bongardt S, Kilgallen B, Galateanu C, Kalunian K, Furie R, Gordon C. Long-term safety and efficacy of epratuzumab in the treatment of moderate-to-severe systemic lupus erythematosus: results from an open-label extension study. Arthritis Care Res (Hoboken) 2015. [Abstract] EPub

Coagulation Biology Laboratory

Dong W, Wang H, Shahzad K, Bock F, Al-Dabet MM, Ranjan S, Wolter J, Kohli S, Hoffmann J, Dhople VM, Zhu C, Lindquist JA, Esmon CT, Grone E, Grone HJ, Madhusudhan T, Mertens PR, Schluter D, Isermann B. Activated protein C ameliorates renal ischemia-reperfusion injury by restricting Y-box binding Protein-1 ubiquitination. J Am Soc Nephrol 2015. [Abstract] EPub

Greineder CF, Brenza JB, Carnemolla R, Zaitsev S, Hood ED, Pan DC, Ding BS, Esmon CT, Chacko AM, Muzykantov VR. Dual targeting of therapeutics to endothelial cells: collaborative enhancement of delivery and effect. FASEB J 29:3483-3492,2015. [Abstract]

Mann KG, Freeman K, TACTIC Investigator list. TACTIC: Trans-Agency Consortium for Trauma-Induced Coagulopathy. J Thromb Haemost 13 Suppl 1:S63-S71, 2015. [Abstract]

Ogbechi J, Ruf MT, Hall BS, Bodman-Smith K, Vogel M, Wu HL, Stainer A, Esmon CT, Ahnstrom J, Pluschke G, Simmonds RE. Mycolactone-dependent depletion of endothelial cell thrombomodulin is strongly associated with fibrin deposition in Buruli Ulcer lesions. PLoS Pathog 11:e1005011, 2015. [Abstract]

Rathbun S, Tafur A, Grant R, Esmon N, Mauer K, Marlar RA. Comparison of methods to determine rivaroxaban anti-factor Xa activity. Thromb Res 135:394-397, 2015. [Abstract]

Sampath S, Brazier AJ, Avril M, Bernabeu M, Vigdorovich V, Mascarenhas A, Gomes E, Sather DN, Esmon CT, Smith JD. Plasmodium falciparum adhesion domains linked to severe malaria differ in blockade of endothelial protein C receptor. Cell Microbiol 2015. [Abstract] EPub

Schouten M, van ‘t Veer C, Poulussen N, Meijers JC, Levi M, Esmon CT, van der Poll T. The cytoprotective effects of endogenous activated protein C reduce activation of coagulation during murine pneumococcal pneumonia and sepsis. Thromb Res 135:537-543, 2015. [Abstract]

Starr ME, Takahashi H, Okamura D, Zwischenberger BA, Mrazek AA, Ueda J, Stromberg AJ, Evers BM, Esmon CT, Saito H. Increased coagulation and suppressed generation of activated protein C in aged mice during intra-abdominal sepsis. Am J Physiol Heart Circ Physiol 308:H83-H91, 2015. [Abstract]

Genetic Models of Disease Research Program

Mathews EA, Mullen GP, Manjarrez JR, Rand JB. Unusual regulation of splicing of the cholinergic locus in Caenorhabditis elegans. Genetics 199:729-737, 2015. [Abstract]

Immunobiology and Cancer Research Program

Basham KJ, Leonard CJ, Kieffer C, Shelton DN, McDowell ME, Bhonde VR, Looper RE, Welm BE. Dioxin exposure blocks lactation through a direct effect on mammary epithelial cells mediated by the Aryl hydrocarbon receptor repressor. Toxicol Sci 143:36-45, 2015. [Abstract]

Bieniasz M, Radhakrishnan P, Faham N, De La OJ, Welm AL. Pre-clinical efficacy of Ron kinase inhibitors alone and in combination with PI3K inhibitors for treatment of sfRon-expressing breast cancer patient-derived xenografts. Clin Cancer Res 2015. [Abstract] EPub

* James JA, Thompson LF, Budd RC. J. Donald Capra, M.D. (1937-2015). J Immunol 194:5575-5576, 2015. [Abstract]

* Ratliff ML, Ward JM, Merrill JT, James JA, Webb CF. Differential expression of the transcription factor ARID3a in lupus patient hematopoietic progenitor cells. J Immunol 2015. [Abstract] EPub

Shen L, O’Shea JM, Kaadige MR, Cunha S, Wilde BR, Cohen AL, Welm AL, Ayer DE. Metabolic reprogramming in triple-negative breast cancer through Myc suppression of TXNIP. Proc Natl Acad Sci U S A 112:5425-5430,2015. [Abstract]

Simmons A, Alberola-Ila J. Retroviral transduction of T cells and T cell precursors. Methods Mol Biol 1323:99-108, 2016. [Abstract]

Webb CF, Ratliff ML, Powell R, Wirsig-Wiechmann CR, Lakiza O, Obara T. A developmentally plastic adult mouse kidney cell line spontaneously generates multiple adult kidney structures. Biochem Biophys Res Commun 463:1334-1340,2015. [Abstract]

Yokota T, Oritani K, Sudo T, Ishibashi T, Doi Y, Habuchi Y, Ichii M, Fukushima K, Okuzaki D, Tomizuka K, Yamawaki K, Kakitani M, Shimono A, Morii E, Kincade PW, Kanakura Y. Estrogen-inducible sFRP5 inhibits early B-lymphopoiesis in vivo, but not during pregnancy. Eur J Immunol 45:1390-1401,2015. [Abstract]

Lipid Studies Laboratory

Kiani AN, Fang H, Akhter E, Quiroga C, Simpson N, Alaupovic P, Magder LS, Petri M. Apolipoprotein-containing lipoprotein subclasses and subclinical atherosclerosis in systemic lupus erythematosus. Arthritis Care Res (Hoboken) 67:442-446, 2015. [Abstract]

Skulas-Ray AC, Alaupovic P, Kris-Etherton PM, West SG. Dose-response effects of marine omega-3 fatty acids on apolipoproteins, apolipoprotein-defined lipoprotein subclasses, and Lp-PLA2 in individuals with moderate hypertriglyceridemia. J Clin Lipidol 9:360-367, 2015. [Abstract]

Protein Studies

Devi L, Tang J, Ohno M. Beneficial effects of the beta-secretase inhibitor GRL-8234 in 5XFAD Alzheimer’s transgenic mice lessen during disease progression. Curr Alzheimer Res 12:13-21, 2015. [Abstract]

Ghosh AK, Brindisi M, Yen Y, Xu X, Huang X, Devasamudram T, Bilcer G, Lei H, Koelsch G, Mesecar AD, Tang J. Structure-based design, synthesis and biological evaluation of novel beta-secretase inhibitors containing a pyrazole or thiazole moiety as the P3 ligand. Bioorg Med Chem Lett 25:668-672, 2015. [Abstract]

Ghosh AK, Tang J. Prospects of beta-Secretase Inhibitors for the Treatment of Alzheimer’s Disease. ChemMedChem 10:1463-1466, 2015. [Abstract]

* Indicates publications by more than one department or group.

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