2008 Scientific Publications

Advanced Magnetic Resonance Center

* Asanuma T, Doblas S, Tesiram YA, Saunders D, Cranford R, Yasui H, Inanami O, Smith N, Floyd RA, Kotake Y, Towner RA. Visualization of the protective ability of a free radical trapping compound against rat C6 and F98 gliomas with diffusion tensor fiber tractography. J Magn Reson Imaging 28:574-587, 2008. [Abstract]

Asanuma T, Doblas S, Tesiram YA, Saunders D, Cranford R, Pearson J, Abbott A, Smith N, Towner RA. Diffusion tensor imaging and fiber tractography of C6 rat glioma. J Magn Reson Imaging 28:566-573, 2008. [Abstract]

Chen Y, Gnyawali SC, Wu F, Liu H, Tesiram YA, Abbott A, Towner RA, Chen WR. Magnetic resonance imaging guidance for laser photothermal therapy. J Biomed Opt 13:044033, 2008. [Abstract]

*Floyd RA, Kopke RD, Choi CH, Foster SB, Doblas S, Towner RA. Nitrones as therapeutics. Free Radic Biol Med 45:1361-1374, 2008. [Abstract]

Arthritis and Immunology Research Program

Bautista JF, Kelly JA, Harley JB, Gray-McGuire C. Addressing genetic heterogeneity in complex disease: finding seizure genes in systemic lupus erythematosus. Epilepsia 49:527-30, 2008. [Abstract]

Bingham A, Mamyrova G, Rother KI, Oral E, Cochran E, Premkumar A, Kleiner D, James-Newton L, Targoff IN, Pandey JP, Carrick DM, Sebring N, O’Hanlon TP, Ruiz-Hidalgo M, Turner M, Gordon LB, Laborda J, Bauer SR, Blackshear PJ, Imundo L, Miller FW, Rider LG, Childhood Myositis Heterogeneity Study Group. Predictors of acquired lipodystrophy in juvenile-onset dermatomyositis and a gradient of severity. Medicine (Baltimore) 87:70-86, 2008. [Abstract]

Carreras E, Turner S, Paharkova-Vatchkova V, Mao A, Dascher C, Kovats S. Estradiol acts directly on bone marrow myeloid progenitors to differentially regulate GM-CSF or Flt3 ligand-mediated dendritic cell differentiation. J Immunol 180:727-738, 2008. [Abstract]

Catera R, Silverman GJ, Hatzi K, Seiler T, Didier S, Zhang L, Herve M, Meffre E, Oscier DG, Vlassara H, Scofield RH, Chen Y, Allen SL, Kolitz J, Rai KR, Chu CC, Chiorazzi N. Chronic lymphocytic leukemia cells recognize conserved epitopes associated with apoptosis and oxidation. Mol Med 14:665-674, 2008. [Abstract]

Cobb BL, Lessard CJ, Harley JB, Moser KL. Genes and Sjögren’s syndrome. Rheum Dis Clin North Am 34:847-68, vii, 2008. [Abstract]

Cooper GS, Gilbert KM, Greidinger EL, James JA, Pfau JC, Reinlib L, Richardson BC, Rose NR. Recent advances and opportunities in research on lupus: environmental influences and mechanisms of disease. Environ Health Perspect 116:695-702, 2008. [Abstract]

* D’Souza A, Kurien BT, Rodgers R, Shenoi J, Kurono S, Matsumoto H, Hensley K, Nath SK, Scofield RH. Detection of catalase as a major protein target of the lipid peroxidation product 4-HNE and the lack of its genetic association as a risk factor in SLE. BMC Med Genet 9:62, 2008. [Abstract]

Dozmorov MG, Kyker KD, Hauser PJ, Saban R, Buethe DD, Dozmorov I, Centola MB, Culkin DJ, Hurst RE. From microarray to biology: an integrated experimental, statistical and in silico analysis of how the extracellular matrix modulates the phenotype of cancer cells. BMC Bioinformatics 9 Suppl 9:S4, 2008. [Abstract]

Edberg JC, Wu J, Langefeld CD, Brown EE, Marion MC, McGwin G, Jr., Petri M, Ramsey-Goldman R, Reveille JD, Frank SG, Kaufman KM, Harley JB, Alarcón GS, Kimberly RP. Genetic variation in the CRP promoter: association with systemic lupus erythematosus. Hum Mol Genet 17:1147-1155, 2008. [Abstract]

Errami M, Hicks JM, Fisher W, Trusty D, Wren JD, Long TC, Garner HR. Déjà vu–a study of duplicate citations in Medline. Bioinformatics 24:243-9, 2008. [Abstract]

Flohe SB, Agrawal H, Flohe S, Rani M, Bangen JM, Schade FU. Diversity of interferon gamma and granulocyte-macrophage colony-stimulating factor in restoring immune dysfunction of dendritic cells and macrophages during polymicrobial sepsis. Mol Med 14:247-256, 2008. [Abstract]

Giles CB, Wren JD. Large-scale directional relationship extraction and resolution. BMC Bioinformatics 9 Suppl 9:S11, 2008. [Abstract]

Graham RR, Cotsapas C, Davies L, Hackett R, Lessard CJ, Leon JM, Burtt NP, Guiducci C, Parkin M, Gates C, Plenge RM, Behrens TW, Wither JE, Rioux JD, Fortin PR, Graham DC, Wong AK, Vyse TJ, Daly MJ, Altshuler D, Moser KL, Gaffney PM. Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus. Nat Genet 40:1059-1061, 2008. [Abstract]

Han S, Guthridge JM, Harley IT, Sestak AL, Kim-Howard X, Kaufman KM, Namjou B, Deshmukh H, Bruner G, Espinoza LR, Gilkeson GS, Harley JB, James JA, Nath SK. Osteopontin and systemic lupus erythematosus association: a probable gene-gender interaction. PLoS ONE 3:e0001757, 2008. [Abstract]

* International Consortium for Systemic Lupus Erythematosus Genetics (SLEGEN), Harley JB, Alarcón-Riquelme ME, Criswell LA, Jacob CO, Kimberly RP, Moser KL, Tsao BP, Vyse TJ, Langefeld CD, Nath SK, Guthridge JM, Cobb BL, Mirel DB, Marion MC, Williams AH, Divers J, Wang W, Frank SG, Namjou B, Gabriel SB, Lee AT, Gregersen PK, Behrens TW, Taylor KE, Fernando M, Zidovetzki R, Gaffney PM, Edberg JC, Rioux JD, Ojwang JO, James JA, Merrill JT, Gilkeson GS, Seldin MF, Yin H, Baechler EC, Li QZ, Wakeland EK, Bruner GR, Kaufman KM, Kelly JA. Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci. Nat Genet 40:204-210, 2008. [Abstract]

Jackson SM, Wilson PC, James JA, Capra JD. Human B cell subsets. Adv Immunol 98:151-224, 2008. [Abstract]

Jeffries M, Bruner G, Glenn S, Sadanandan P, Carson CW, Harley J, Sawalha AH. Sulpha allergy in lupus patients: a clinical perspective. Lupus 17:202-205, 2008. [Abstract]

Jeffries M, Hamadeh F, Aberle T, Glenn S, Kamen DL, Kelly JA, Reichlin M, Harley JB, Sawalha AH. Haemolytic anaemia in a multi-ethnic cohort of lupus patients: a clinical and serological perspective. Lupus 17:739-743, 2008. [Abstract]

Kamen DL, Barron M, Parker TM, Shaftman SR, Bruner GR, Aberle T, James JA, Scofield RH, Harley JB, Gilkeson GS. Autoantibody prevalence and lupus characteristics in a unique African American population. Arthritis Rheum 58:1237-1247, 2008. [Abstract]

Katzav A, Ben-Ziv T, Chapman J, Blank M, Reichlin M, Shoenfeld Y. Anti-P ribosomal antibodies induce defect in smell capability in a model of CNS -SLE (depression). J Autoimmun 31:393-398, 2008. [Abstract]

* Kelly JA, Kelley JM, Kaufman KM, Kilpatrick J, Bruner GR, Merrill JT, James JA, Frank SG, Reams E, Brown EE, Gibson AW, Marion MC, Langefeld CD, Li QZ, Karp DR, Wakeland EK, Petri M, Ramsey-Goldman R, Reveille JD, Vilá LM, Alarcón GS, Kimberly RP, Harley JB, Edberg JC. Interferon regulatory factor-5 is genetically associated with systemic lupus erythematosus in African Americans. Genes Immun 9:187-194, 2008. [Abstract]

Kovats S, Carreras E. Regulation of dendritic cell differentiation and function by estrogen receptor ligands. Cell Immunol 252:81-90, 2008. [Abstract]

Kurien BT, Scofield RH. Autoimmunity and oxidatively modified autoantigens. Autoimmun Rev 7:567-573, 2008. [Abstract]

Kurien BT, Scofield RH. 4-Hydroxynonenal-modified Ro 60 autoantigen accelerates autoimmunity in experimental animals. Rheumatology (Oxford) 47:1587, 2008. [Abstract]

Kurien BT, Scofield RH. Lipstick consumption and systemic lupus erythematosus: nothing to gloss over. Clin Rheumatol 27:1339-1340, 2008. [Abstract]

Lundberg P, Ramakrishna C, Brown J, Tyszka JM, Hamamura M, Hinton DR, Kovats S, Nalcioglu O, Weinberg K, Openshaw H, Cantin EM. The immune response to herpes simplex virus type 1 infection in susceptible mice is a major cause of CNS pathology resulting in fatal encephalitis. J Virol 82:7078-7088, 2008. [Abstract]

Mathews SA, Kurien BT, Scofield RH. Oral manifestations of Sjogren’s Syndrome. J Dent Res 87:308-318, 2008. [Abstract]

Nakou M, Knowlton N, Frank MB, Bertsias G, Osban J, Sandel CE, Papadaki H, Raptopoulou A, Sidiropoulos P, Kritikos I, Tassiulas I, Centola M, Boumpas DT. Gene expression in systemic lupus erythematosus: Bone marrow analysis differentiates active from inactive disease and reveals apoptosis and granulopoiesis signatures. Arthritis Rheum 58:3541-3549, 2008. [Abstract]

* Nath SK, Han S, Kim-Howard X, Kelly JA, Viswanathan P, Gilkeson GS, Chen W, Zhu C, McEver RP, Kimberly RP, Alarcón-Riquelme ME, Vyse TJ, Li QZ, Wakeland EK, Merrill JT, James JA, Kaufman KM, Guthridge JM, Harley JB. A nonsynonymous functional variant in integrin-alpha(M) (encoded by ITGAM) is associated with systemic lupus erythematosus. Nat Genet 40:152-154, 2008. [Abstract]

Niewold TB, Adler JE, Glenn SB, Lehman TJ, Harley JB, Crow MK. Age- and sex-related patterns of serum interferon-alpha activity in lupus families. Arthritis Rheum 58:2113-2119, 2008. [Abstract]

Niewold TB, Kelly JA, Flesch MH, Espinoza LR, Harley JB, Crow MK. Association of the IRF5 risk haplotype with high serum interferon-alpha activity in systemic lupus erythematosus patients. Arthritis Rheum 58:2481-2487, 2008. [Abstract]

O’Hanlon TP, Rider LG, Schiffenbauer A, Targoff IN, Malley K, Pandey JP, Miller FW. Immunoglobulin gene polymorphisms are susceptibility factors in clinical and autoantibody subgroups of the idiopathic inflammatory myopathies. Arthritis Rheum 58:3239-3246, 2008. [Abstract]

Poole BD, Gross T, Maier S, Harley JB, James JA. Lupus-like autoantibody development in rabbits and mice after immunization with EBNA-1 fragments. J Autoimmun 31:362-371, 2008. [Abstract]

Saban MR, O’Donnell MA, Hurst RE, Wu XR, Simpson C, Dozmorov I, Davis C, Saban R. Molecular networks discriminating mouse bladder responses to intravesical bacillus Calmette-Guerin (BCG), LPS, and TNF-alpha. BMC Immunol 9:4, 2008. [Abstract]

Sanghera DK, Nath SK, Ortega L, Gambarelli M, Kim-Howard X, Singh JR, Ralhan SK, Wander GS, Mehra NK, Mulvihill JJ, Kamboh MI. TCF7L2 polymorphisms are associated with type 2 diabetes in Khatri Sikhs from North India: genetic variation affects lipid levels. Ann Hum Genet 72:499-509, 2008. [Abstract]

Sanghera DK, Ortega L, Han S, Singh J, Ralhan SK, Wander GS, Mehra NK, Mulvihill JJ, Ferrell RE, Nath SK, Kamboh MI. Impact of nine common type 2 diabetes risk polymorphisms in Asian Indian Sikhs: PPARG2 (Pro12Ala), IGF2BP2, TCF7L2 and FTO variants confer a significant risk. BMC Med Genet 9:59, 2008. [Abstract]

Sawalha AH. Epigenetics and T-cell immunity. Autoimmunity 41:245-252, 2008. [Abstract]

Sawalha AH, Jeffries M, Webb R, Lu Q, Gorelik G, Ray D, Osban J, Knowlton N, Johnson K, Richardson B. Defective T-cell ERK signaling induces interferon-regulated gene expression and overexpression of methylation-sensitive genes similar to lupus patients. Genes Immun 9:368-378, 2008. [Abstract]

* Sawalha AH, Kaufman KM, Kelly JA, Adler AJ, Aberle T, Kilpatrick J, Wakeland EK, Li QZ, Wandstrat AE, Karp DS, James JA, Merrill JT, Lipsky P, Harley JB. Genetic association of interleukin-21 polymorphisms with systemic lupus erythematosus. Ann Rheum Dis 67:458-461, 2008. [Abstract]

Sawalha AH, Kovats S. Dehydroepiandrosterone in systemic lupus erythematosus. Curr Rheumatol Rep 10:286-291, 2008. [Abstract]

Sawalha AH, Webb R, Han S, Kelly JA, Kaufman KM, Kimberly RP, Alarcón-Riquelme ME, James JA, Vyse TJ, Gilkeson GS, Choi CB, Scofield RH, Bae SC, Nath SK, Harley JB. Common variants within MECP2 confer risk of systemic lupus erythematosus. PLoS ONE 3:e1727, 2008. [Abstract]

Scofield RH, Bruner GR, Namjou B, Kimberly RP, Ramsey-Goldman R, Petri M, Reveille JD, Alarcon GS, Vila LM, Reid J, Harris B, Li S, Kelly JA, Harley JB. Klinefelter’s syndrome (47,XXY) in male systemic lupus erythematosus patients: Support for the notion of a gene-dose effect from the X chromosome. Arthritis Rheum 58:2511-2517, 2008. [Abstract]

Segal B, Thomas W, Rogers T, Leon JM, Hughes P, Patel D, Patel K, Novitzke J, Rohrer M, Gopalakrishnan R, Myers S, Nazmul-Hossain A, Emamian E, Huang A, Rhodus N, Moser K. Prevalence, severity, and predictors of fatigue in subjects with primary Sjogren’s syndrome. Arthritis Care Res (Hoboken) 59:1780-1787, 2008. [Abstract]

Sestak A, Nath S, Kelly J, Bruner G, James J, Harley J. Patients with familial and sporadic onset SLE have similar clinical profiles but vary profoundly by race. Lupus 17:1004-1009, 2008. [Abstract]

Targoff IN. Autoantibodies and their significance in myositis. Curr Rheumatol Rep 10:333-340, 2008. [Abstract]

Thanou-Stavraki A, James JA. Primary Sjogren’s Syndrome: current and prospective therapies. Semin Arthritis Rheum 37:273-292, 2008.[Abstract]

Wang H, Kesinger JW, Zhou Q, Wren JD, Martin G, Turner S, Tang Y, Frank MB, Centola M. Identification and characterization of zebrafish ocular formation genes. Genome 51:222-235, 2008. [Abstract]

Wrammert J, Smith K, Miller J, Langley WA, Kokko K, Larsen C, Zheng NY, Mays I, Garman L, Helms C, James J, Air GM, Capra JD, Ahmed R, Wilson PC. Rapid cloning of high-affinity human monoclonal antibodies against influenza virus. Nature 453:667-71, 2008. [Abstract]

Wren JD. URL decay in MEDLINE–a 4-year follow-up study. Bioinformatics 24:1381-1385, 2008. [Abstract]

Zhang W, Reichlin M. A possible link between infection with Burkholderia bacteria and systemic lupus erythematosus based on epitope mimicry. Clin Dev Immunol 2008:683489, 2008. [Abstract]

Cardiovascular Biology Research Program

An G, Wang H, Tang R, Yago T, McDaniel JM, McGee S, Huo Y, Xia L. P-selectin glycoprotein ligand-1 is highly expressed on Ly-6Chi monocytes and a major determinant for Ly-6Chi monocyte recruitment to sites of atherosclerosis in mice. Circulation 117:3227-3237, 2008. [Abstract]

Aragonés J, Schneider M, Van Geyte K., Fraisl P, Dresselaers T, Mazzone M, Dirkx R, Zacchigna S, Lemieux H, Jeoung NH, Lambrechts D, Bishop T, Lafuste P, Diez-Juan A, Harten SK, Van Noten P., De Bock K., Willam C, Tjwa M, Grosfeld A, Navet R, Moons L, Vandendriessche T, Deroose C, Wijeyekoon B, Nuyts J, Jordan B, Silasi-Mansat R, Lupu F, Dewerchin M, Pugh C, Salmon P, Mortelmans L, Gallez B, Gorus F, Buyse J, Sluse F, Harris RA, Gnaiger E, Hespel P, Van Hecke P., Schuit F, Van Veldhoven P., Ratcliffe P, Baes M, Maxwell P, Carmeliet P. Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism. Nat Genet 40:170-180, 2008. [Abstract]

Chen W, Evans EA, McEver RP, Zhu C. Monitoring receptor-ligand interactions between surfaces by thermal fluctuations. Biophys J 94:694-701, 2008. [Abstract]

Danan LM, Yu Z, Hoffhines AJ, Moore KL, Leary JA. Mass spectrometric kinetic analysis of human tyrosylprotein sulfotransferase-1 and -2. J Am Soc Mass Spectrom 19:1459-1466, 2008. [Abstract]

Fabene PF, Mora GN, Martinello M, Rossi B, Merigo F, Ottoboni L, Bach S, Angiari S, Benati D, Chakir A, Zanetti L, Schio F, Osculati A, Marzola P, Nicolato E, Homeister JW, Xia L, Lowe JB, McEver RP, Osculati F, Sbarbati A, Butcher EC, Constantin G. A role for leukocyte-endothelial adhesion mechanisms in epilepsy. Nat Med 14:1377-1383, 2008. [Abstract]

Fu J, Gerhardt H, McDaniel JM, Xia B, Liu X, Ivanciu L, Ny A, Hermans K, Silasi-Mansat R, McGee S, Nye E, Ju T, Ramirez MI, Carmeliet P, Cummings RD, Lupu F, Xia L. Endothelial cell O-glycan deficiency causes blood/lymphatic misconnections and consequent fatty liver disease in mice. J Clin Invest 118:3725-3737, 2008. [Abstract]

Johnson CM, Chichili GR, Rodgers W. Compartmentalization of phosphatidylinositol 4,5-bisphosphate signaling evidenced using targeted phosphatases. J Biol Chem 283:29920-29928, 2008. [Abstract]

Johnson CM, Rodgers W. Spatial segregation of phosphatidylinositol 4,5 biphosphate (PIP₂) signaling in immune cell functions. Immunol Endocr Metabol Agents Med 8, 349-357, 2008. [Abstract]

Karmakar S, Stowell SR, Cummings RD, McEver RP. Galectin-1 signaling in leukocytes requires expression of complex-type N-glycans. Glycobiology 18:770-778, 2008. [Abstract]

Klopocki AG, Yago T, Mehta P, Yang J, Wu T, Leppänen A, Bovin NV, Cummings RD, Zhu C, McEver RP. Replacing a lectin domain residue in L-selectin enhances binding to P-selectin glycoprotein ligand-1 but not to 6-Sulfo-sialyl Lewis x. J Biol Chem 283:11493-11500, 2008. [Abstract]

Koenig A, Russell JQ, Rodgers WA, Budd RC. Spatial differences in active caspase-8 defines its role in T-cell activation versus cell death. Cell Death Differ 15:1701-1711, 2008. [Abstract]

Lelievre E, Hinek A, Lupu F, Buquet C, Soncin F, Mattot V. VE-statin/egfl7 regulates vascular elastogenesis by interacting with lysyl oxidases. EMBO J 27:1658-1670, 2008. [Abstract]

Li W, Adams TE, Nangalia J, Esmon CT, Huntington JA. Molecular basis of thrombin recognition by protein C inhibitor revealed by the 1.6-A structure of the heparin-bridged complex. Proc Natl Acad Sci U S A 105:4661-4666, 2008. [Abstract]

Lupu F. “Crossroads in Sepsis Research” Review Series overview of the pathophysiology of sepsis. J Cell Mol Med 12:1072-1073, 2008. [Abstract]

Lupu F. Laudatio to professor Fletcher B. Taylor. J Cell Mol Med 12:1069-1071, 2008. [Abstract]

Miner JJ, Xia L, Yago T, Kappelmayer J, Liu Z, Klopocki AG, Shao B, McDaniel JM, Setiadi H, Schmidtke DW, McEver RP. Separable requirements for cytoplasmic domain of PSGL-1 in leukocyte rolling and signaling under flow. Blood 112:2035-2045, 2008. [Abstract]

Saposnik B, Lesteven E, Lokajczyk A, Esmon CT, Aiach M, Gandrille S. Alternative mRNA splicing is favored by the A3 haplotype of the EPCR gene PROCR and generates a novel soluble form of EPCR in plasma. Blood 111:3442-3451, 2008. [Abstract]

Setiadi H, McEver RP. Clustering endothelial e-selectin in clathrin-coated pits and lipid rafts enhances leukocyte adhesion under flow. Blood 111:1989-98, 2008. [Abstract]

Stowell SR, Arthur CM, Mehta P, Slanina KA, Blixt O, Leffler H, Smith DF, Cummings RD. Galectin-1, -2, and -3 exhibit differential recognition of sialylated glycans and blood group antigens. J Biol Chem 283:10109-10123, 2008. [Abstract]

Stowell SR, Qian Y, Karmakar S, Koyama NS, Dias-Baruffi M, Leffler H, McEver RP, Cummings RD. Differential roles of galectin-1 and galectin-3 in regulating leukocyte viability and cytokine secretion. J Immunol 180:3091-3102, 2008. [Abstract]

* Takedachi M, Qu D, Ebisuno Y, Oohara H, Joachims ML, McGee ST, Maeda E, McEver RP, Tanaka T, Miyasaka M, Murakami S, Krahn T, Blackburn MR, Thompson LF. CD73-generated adenosine restricts lymphocyte migration into draining lymph nodes. J Immunol 180:6288-6296, 2008. [Abstract]

Tjwa M, Bellido-Martin L, Lin Y, Lutgens E, Plaisance S, Bono F, Delesque-Touchard N, Hervé C, Moura R, Billiau AD, Aparicio C, Levi M, Daemen M, Dewerchin M, Lupu F, Arnout J, Herbert JM, Waer M, Garcia de Frutos P., Dahlbäck B, Carmeliet P, Hoylaerts MF, Moons L. Gas6 promotes inflammation by enhancing interactions between endothelial cells, platelets and leukocytes. Blood 111:4096-4105, 2008. [Abstract]

* Towner RA, Smith N, Doblas S, Tesiram Y, Garteiser P, Saunders D, Cranford R, Silasi-Mansat R, Herlea O, Ivanciu L, Wu D, Lupu F. In vivo detection of c-Met expression in a rat C6 glioma model. J Cell Mol Med 12:174-186, 2008. [Abstract]

Varki AP, Baum LG, Bellis SL, Cummings RD, Esko JD, Hart GW, Linhardt RJ, Lowe JB, McEver RP, Srivastava A, Sarkar R. Working Group Report: The roles of glycans in hemostasis, inflammation and vascular biology. Glycobiology 18:747-749, 2008. [Abstract]

Westmuckett AD, Hoffhines AJ, Borghei A, Moore KL. Early postnatal pulmonary failure and primary hypothyroidism in mice with combined TPST-1 and TPST-2 deficiency. Gen Comp Endocrinol. 156:145-53, 2008. [Abstract]

Yago T, Lou J, Wu T, Yang J, Miner JJ, Coburn L, Lopez JA, Cruz MA, Dong JF, McIntire LV, McEver RP, Zhu C. Platelet glycoprotein Ibalpha forms catch bonds with human WT vWF but not with type 2B von Willebrand disease vWF. J Clin Invest 118:3195-3207, 2008. [Abstract]

Yoshida H, Russell J, Stokes KY, Yilmaz CE, Esmon CT, Granger DN. Role of the protein C pathway in the extraintestinal thrombosis associated with murine colitis. Gastroenterology 135:882-888, 2008. [Abstract]

Zhu C, Yago T, Lou J, Zarnitsyna VI, McEver RP. Mechanisms for flow-enhanced cell adhesion. Ann Biomed Eng 36:604-621, 2008. [Abstract]

Cell Cycle and Cancer Biology Research Program

Conrad MN, Lee CY, Chao G, Shinohara M, Kosaka H, Shinohara A, Conchello JA, Dresser ME. Rapid telomere movement in meiotic prophase is promoted by NDJ1, MPS3, and CSM4 and is modulated by recombination. Cell 133:1175-1187, 2008. [Abstract]

Dresser ME. Chromosome mechanics and meiotic engine maintenance. PLoS Genet 4:e1000210, 2008. [Abstract]

Clinical Pharmacology Research Program

Asherson RA, Cervera R, Merrill JT, Erkan D. Antiphospholipid antibodies and the antiphospholipid syndrome: clinical significance and treatment. Semin Thromb Hemost 34:256-266, 2008. [Abstract]

Furie R, Stohl W, Ginzler EM, Becker M, Mishra N, Chatham WW, Merrill JT, Weinstein A, McCune WJ, Zhong J, Cai W, Freimuth W, Study Group. Biologic activity and safety of Belimumab, a neutralizing anti-B-lymphocyte stimulator (BLyS) monoclonal antibody: a phase I trial in patients with systemic lupus erythematosus. Arthritis Res Ther 10:R109, 2008. [Abstract]

Hanly JG, Urowitz MB, Siannis F, Farewell V, Gordon C, Bae SC, Isenberg D, Dooley MA, Clarke A, Bernatsky S, Gladman D, Fortin PR, Manzi S, Steinsson K, Bruce IN, Ginzler E, Aranow C, Wallace DJ, Ramsey-Goldman R, van Vollenhoven R, Sturfelt G, Nived O, Sanchez-Guerrero J, Alarcón GS, Petri M, Khamashta M, Zoma A, Font J, Kalunian K, Douglas J, Qi Q, Thompson K, Merrill JT. Autoantibodies and neuropsychiatric events at the time of systemic lupus erythematosus diagnosis: Results from an international inception cohort study. Arthritis Rheum 58:843-853, 2008. [Abstract]

Hanly JG, Urowitz MB, Su L, Sanchez-Guerrero J, Bae SC, Gordon C, Wallace DJ, Isenberg D, Alarcon GS, Merrill JT, Clarke A, Bernatsky S, Dooley MA, Fortin PR, Gladman D, Steinsson K, Petri M, Bruce IN, Manzi S, Khamashta M, Zoma A, Font J, van Vollenhoven R., Aranow C, Ginzler E, Nived O, Sturfelt G, Ramsey-Goldman R, Kalunian K, Douglas J, Qiufen QK, Thompson K, Farewell V, Systemic Lupus International Collaborating Clinics. Short-term outcome of neuropsychiatric events in systemic lupus erythematosus upon enrollment into an international inception cohort study. Arthritis Rheum 59:721-729, 2008.[Abstract]

Isenberg D, Gordon C, Merrill J, Urowitz M. New therapies in systemic lupus erythematosus – trials, troubles and tribulations…. working towards a solution. Lupus 17:967-970, 2008. [Abstract]

Merrill JT. Biomarkers relevant to atacicept effects in systemic lupus erythematosus patients. Curr Rheumatol Rep 10:264, 2008. [Abstract]

Merrill JT. Is individualized medicine on the horizon for lupus? Curr Rheumatol Rep 10:257-258, 2008. [Abstract]

Merrill JT. Testosterone patches in systemic lupus erythematosus. Curr Rheumatol Rep 10:263, 2008. [Abstract]

Merrill JT. Topical tacrolimus and pimecrolimus for cutaneous lupus. Curr Rheumatol Rep 10:263-264, 2008. [Abstract]

Olech E, Freeston JE, Conaghan PG, Hensor EM, Emery P, Yocum D. Using extremity magnetic resonance imaging to assess and monitor early rheumatoid arthritis: the optimal joint combination to be scanned in clinical practice. J Rheumatol 35:580-583, 2008. [Abstract]

Petri M, Kasitanon N, Singh S, Link K, Magder L, Bae SC, Hanly JG, Nived O, Sturfelt G, van Vollenhoven R, Wallace DJ, Alarcón GS, Adu D, A vila-Casado C, Bernatsky SR, Bruce IN, Clarke AE, Contreras G, Fine DM, Gladman DD, Gordon C, Kalunian KC, Madaio MP, Rovin BH, Sanchez-Guerrero J, Steinsson K, Aranow C, Balow JE, Buyon JP, Ginzler EM, Khamashta MA, Urowitz MB, Dooley MA, Merrill JT, Ramsey-Goldman R, Font J, Tumlin J, Stoll T, Zoma A, Systemic Lupus International Collaborating Clinics. Systemic lupus International Collaborating Clinics renal activity/response exercise: comparison of agreement in rating renal response. Arthritis Rheum 58:1789-1795, 2008. [Abstract]

Petri M, Kasitanon N, Lee SS, Link K, Magder L, Bae SC, Hanly JG, Isenberg DA, Nived O, Sturfelt G, van Vollenhoven R., Wallace DJ, Alarcón GS, Adu D, Avila-Casado C, Bernatsky SR, Bruce IN, Clarke AE, Contreras G, Fine DM, Gladman DD, Gordon C, Kalunian KC, Madaio MP, Rovin BH, Sanchez-Guerrero J, Steinsson K, Aranow C, Balow JE, Buyon JP, Ginzler EM, Khamashta MA, Urowitz MB, Dooley MA, Merrill JT, Ramsey-Goldman R, Font J, Tumlin J, Stoll T, Zoma A, Systemic Lupus International Collaborating Clinics. Systemic Lupus International Collaborating Clinics renal activity/response exercise: development of a renal activity score and renal response index. Arthritis Rheum 58:1784-1788, 2008. [Abstract]

Urowitz MB, Gladman D, Ibañez D, Fortin P, Sanchez-Guerrero J, Bae S, Clarke A, Bernatsky S, Gordon C, Hanly J, Wallace D, Isenberg D, Ginzler E, Merrill J, Alarcon GS, Steinsson K, Petri M, Dooley MA, Bruce I, Manzi S, Khamashta M, Ramsey-Goldman R, Zoma A, Sturfelt G, Nived O, Maddison P, Font J, van Vollenhoven R, Aranow C, Kalunian K, Stoll T. Accumulation of coronary artery disease risk factors over three years: Data from an international inception cohort. Arthritis Rheum 59:176-180, 2008. [Abstract]

Comparative Medicine

* Doblas S, Saunders D, Kshirsagar P, Pye Q, Oblander J, Gordon B, Kosanke S, Floyd RA, Towner RA. Phenyl-tert-butylnitrone induces tumor regression and decreases angiogenesis in a c6 rat glioma model. Free Radic Biol Med 44:63-72, 2008. [Abstract]

Gruber HE, Gordon B, Norton HJ, Kilburn J, Williams C, Zinchenko N, Heath J, Ingram J, Hanley EN, Jr. Analysis of cell death and vertebral end plate bone mineral density in the annulus of the aging sand rat. Spine J 8:475-481, 2008. [Abstract]

Saban MR, Backer JM, Backer MV, Maier J, Fowler B, Davis CA, Simpson C, Wu XR, Birder L, Freeman MR, Soker S, Hurst RE, Saban R. VEGF receptors and neuropilins are expressed in the urothelial and neuronal cells in normal mouse urinary bladder and are upregulated in inflammation. Am J Physiol Renal Physiol 295:F60-F72, 2008. [Abstract]

Crystallography Research Program

Chen J, Li W, Wang M, Zhu G, Liu D, Sun F, Hao N, Li X, Rao Z, Zhang XC. Crystal structure and mutagenic analysis of GDOsp, a gentisate 1,2-dioxygenase from Silicibacter pomeroyi. Protein Sci 17:1362-1373, 2008. [Abstract]

Zhang R, Xu Y, Sun Y, Nie Y, Mu X, Li X, Zhang XC, Rao Z. Crystallization and preliminary X-ray crystallographic analysis of a carbonyl reductase from Candida parapsilosis. Acta Crystallogr Sect F Struct Biol Cryst Commun 64:252-254, 2008. [Abstract]

Experimental Therapeutics Research Center

Choi CH, Chen K, Vasquez-Weldon A, Jackson RL, Floyd RA, Kopke RD. Effectiveness of 4-hydroxy phenyl N-tert-butylnitrone (4-OHPBN) alone and in combination with other antioxidant drugs in the treatment of acute acoustic trauma in chinchilla. Free Radic Biol Med 44:1772-1784, 2008. [Abstract]

*Floyd RA, Kopke RD, Choi CH, Foster SB, Doblas S, Towner RA. Nitrones as therapeutics. Free Radic Biol Med 45:1361-1374, 2008. [Abstract]

* Strong R, Miller RA, Astle CM, Floyd RA, Flurkey K, Hensley KL, Javors MA, Leeuwenburgh C, Nelson JF, Ongini E. Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice. Aging Cell 7:641-650, 2008. [Abstract]

Free Radical Biology and Aging Research Program

Applegate MA, Humphries KM, Szweda LI. Reversible inhibition of alpha-ketoglutarate dehydrogenase by hydrogen peroxide: glutathionylation and protection of lipoic acid. Biochemistry 47:473-478, 2008. [Abstract]

Kamat CD, Gadal S, Mhatre M, Williamson KS, Pye QN, Hensley K. Antioxidants in central nervous system diseases: preclinical promise and translational challenges. J Alzheimers Dis 15:473-493, 2008. [Abstract]

Kurosawa S, Stearns-Kurosawa DJ, Kinasewitz GT. Soluble thrombomodulin: a sign of bad times. Crit Care Med 36:985-987, 2008. [Abstract]

* Langer M, Malykhin A, Maeda K, Chakrabarty K, Williamson KS, Feasley CL, West CM, Metcalf JP, Coggeshall KM. Bacillus anthracis peptidoglycan stimulates an inflammatory response in monocytes through the p38 mitogen-activated protein kinase pathway. PLoS ONE 3:e3706, 2008. [Abstract]

Martin CM, Ferdous A, Gallardo T, Humphries C, Sadek H, Caprioli A, Garcia JA, Szweda LI, Garry MG, Garry DJ. Hypoxia-inducible factor-2{alpha} transactivates Abcg2 and promotes cytoprotection in cardiac side population cells. Circ Res 102:1075-1081, 2008. [Abstract]

Matsumoto T, Kaneko T, Seto M, Wada H, Kobayashi T, Nakatani K, Tonomura H, Tono Y, Ohyabu M, Nobori T, Shiku H, Sudo A, Uchida A, Kurosawa DJ, Kurosawa S. The membrane proteinase 3 expression on neutrophils was downregulated after treatment with infliximab in patients with rheumatoid arthritis. Clin Appl Thromb Hemost 14:186-192, 2008. [Abstract]

Montgomery RL, Potthoff MJ, Haberland M, Qi X, Matsuzaki S, Humphries KM, Richardson JA, Bassel-Duby R, Olson EN. Maintenance of cardiac energy metabolism by histone deacetylase 3 in mice. J Clin Invest 118:3588-3597, 2008. [Abstract]

Tesiram YA, Saunders D, Towner RA. Chemical speciation by selective heteronuclear single-quantum coherence spectroscopy: determination of double-bond quantity in unsaturated fatty acid compounds. NMR Biomed 21:345-356, 2008. [Abstract]

Williamson KS, Morris JB, Pye QN, Kamat CD, Hensley K. A survey of sesamin and composition of tocopherol variability from seeds of eleven diverse sesame (Sesamum indicum L.) genotypes using HPLC-PAD-ECD. Phytochem Anal 19:311-322, 2008. [Abstract]

Wu M, Chen Y, Wilson K, Chirindel A, Ihnat MA, Yu Y, Boulton ME, Szweda LI, Ma JX, Lyons TJ. Intraretinal leakage and oxidation of LDL in diabetic retinopathy. Invest Ophthalmol Vis Sci 49:2679-2685, 2008. [Abstract]

Genetic Models of Disease Research Program

Clarke M, Maddera L, Harris RL, Silverman PM. F-pili dynamics by live-cell imaging. Proc Natl Acad Sci U S A 105:17978-17981, 2008. [Abstract]

Edwards SL, Charlie NK, Milfort MC, Brown BS, Gravlin CN, Knecht JE, Miller KG. A novel molecular solution for ultraviolet light detection in Caenorhabditis elegans. PLoS Biol 6:e198, 2008. [Abstract]

Giorgione J, Clarke M. Heterogeneous modes of uptake for latex beads revealed through live cell imaging of phagocytes expressing a probe for phosphatidylinositol-(3,4,5)-trisphosphate and phosphatidylinositol-(3,4)-bisphosphate. Cell Motil Cytoskeleton 65:721-733, 2008. [Abstract]

Immunobiology and Cancer Research Program

Chen X, Esplin BL, Garrett KP, Welner RS, Webb CF, Kincade PW. Retinoids accelerate B lineage lymphoid differentiation. J Immunol 180:138-145, 2008. [Abstract]

Eckle T, Faigle M, Grenz A, Laucher S, Thompson LF, Eltzschig HK. A2B adenosine receptor dampens hypoxia-induced vascular leak. Blood 111:2024-35, 2008. [Abstract]

Ichii M, Oritani K, Yokota T, Nishida M, Takahashi I, Shirogane T, Ezoe S, Saitoh N, Tanigawa R, Kincade PW, Kanakura Y. Regulation of human B lymphopoiesis by the transforming growth factor-beta superfamily in a newly established coculture system using human mesenchymal stem cells as a supportive microenvironment. Exp Hematol 36:587-597, 2008. [Abstract]

Joachims ML, Marble P, Knott-Craig C, Pastuszko P, Blackburn MR, Thompson LF. Inhibition of deoxynucleoside kinases in human thymocytes prevents dATP accumulation and induction of apoptosis. Nucleosides Nucleotides Nucleic Acids 27:816-820, 2008. [Abstract]

Joachims ML, Marble PA, Laurent AB, Pastuszko P, Paliotta M, Blackburn MR, Thompson LF. Restoration of adenosine deaminase-deficient human thymocyte development in vitro by inhibition of deoxynucleoside kinases. J Immunol 181:8153-8161, 2008. [Abstract]

Lauritsen JP, Kurella S, Lee SY, Lefebvre JM, Rhodes M, Aberola-Ila J, Wiest DL. Egr2 is required for Bcl-2 induction during positive selection. J Immunol 181:7778-7785, 2008. [Abstract]

Malhotra S, Baba Y, Garrett KP, Staal FJ, Gerstein R, Kincade PW. Contrasting responses of lymphoid progenitors to canonical and noncanonical wnt signals. J Immunol 181:3955-3964, 2008. [Abstract]

Mikhailov A, Sokolovskaya A, Yegutkin GG, Amdahl H, West A, Yagita H, Lahesmaa R, Thompson LF, Jalkanen S, Blokhin D, Eriksson JE. CD73 Participates in cellular multiresistance program and protects against TRAIL-induced apoptosis. J Immunol 181:464-475, 2008. [Abstract]

Mills JH, Thompson LF, Mueller C, Waickman AT, Jalkanen S, Niemela J, Airas L, Bynoe MS. CD73 is required for efficient entry of lymphocytes into the central nervous system during experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A 105:9325-9330, 2008. [Abstract]

Nie L, Perry SS, Zhao Y, Huang J, Kincade PW, Farrar MA, Sun XH. Regulation of lymphocyte development by cell type-specific interpretation of notch signals. Mol Cell Biol 28:2078-90, 2008. [Abstract]

Nie L, Wu H, Sun XH. Ubiquitination and degradation of Tal1/SCL is induced by notch signaling and depends on Skp2 and CHIP. J Biol Chem 283:684-92, 2008. [Abstract]

Nixon JC, Ferrell S, Miner C, Oldham AL, Hochgeschwender U, Webb CF. Transgenic mice expressing dominant-negative Bright exhibit defects in B1 B cells. J Immunol 181:6913-6922, 2008. [Abstract]

Thapa M, Welner RS, Pelayo R, Carr DJ. CXCL9 and CXCL10 expression are critical for control of genital herpes simplex virus type 2 infection through mobilization of HSV-specific CTL and NK cells to the nervous system. J Immunol 180:1098-1106, 2008. [Abstract]

Thompson LF, Takedachi M, Ebisuno Y, Tanaka T, Miyasaka M, Mills JH, Bynoe MS. Regulation of leukocyte migration across endothelial barriers by ECTO-5′-nucleotidase-generated adenosine. Nucleosides Nucleotides Nucleic Acids 27:755-760, 2008. [Abstract]

Welner RS, Pelayo R, Kincade PW. Evolving views on the genealogy of B cells. Nat Rev Immunol 8:95-106, 2008. [Abstract]

Welner RS, Pelayo R, Nagai Y, Garrett KP, Wuest TR, Carr DJ, Borghesi LA, Farrar MA, Kincade PW. Lymphoid precursors are directed to produce dendritic cells as a result of TLR9 ligation during herpes infection. Blood 112:3753-3761, 2008 [Abstract]

Yamashita Y, Kouro T, Miyake K, Takatsu K, Kido MA, Tanaka T, Goto M, Kincade PW. Participation of intercellular adhesion molecule-2 (CD102) in B lymphopoiesis. Immunol Lett 120:79-86, 2008. [Abstract]

Yang Y, Wang HC, Sun XH. Id1 induces apoptosis through inhibition of RORgammat expression. BMC Immunol 9:20, 2008. [Abstract]

Yokota T, Oritani K, Garrett KP, Kouro T, Nishida M, Takahashi I, Ichii M, Satoh Y, Kincade PW, Kanakura Y. Soluble Frizzled-related protein 1 is estrogen inducible in bone marrow stromal cells and suppresses the earliest events in lymphopoiesis. J Immunol 181:6061-6072, 2008. [Abstract]

Lipid Studies

Alaupovic P, Blackett P, Wang W, Lee E. Characterization of the metabolic syndrome by apolipoproteins in the Oklahoma Cherokee. J Cardiometab Syndr 3:193-199, 2008. [Abstract]

Gebauer SK, West SG, Kay CD, Alaupovic P, Bagshaw D, Kris-Etherton PM. Effects of pistachios on cardiovascular disease risk factors and potential mechanisms of action: a dose-response study. Am J Clin Nutr 88:651-659, 2008. [Abstract]

Lee DM, Alaupovic P, Knight-Gibson C, Bagdade JD. Apolipoprotein-B subclasses as acceptors of cholesteryl esters transferred by CETP. Eur J Clin Invest 38:734-742, 2008. [Abstract]

Molecular, Cell and Developmental Biology Research Program

Duerr JS, Han HP, Fields SD, Rand JB. Identification of major classes of cholinergic neurons in the nematode Caenorhabditis elegans. J Comp Neurol 506:398-408, 2008. [Abstract]

Karpac J, Czyzewska K, Kern A, Brush RS, Anderson RE, Hochgeschwender U. Failure of adrenal corticosterone production in POMC-deficient mice results from lack of integrated effects of POMC peptides on multiple factors. Am J Physiol Endocrinol Metab 295:E446-E455, 2008. [Abstract]

Mangahas PM, Yu X, Miller KG, Zhou Z. The small GTPase Rab2 functions in the removal of apoptotic cells in Caenorhabditis elegans. J Cell Biol 180:357-373, 2008. [Abstract]

Moerman DG, Barstead RJ. Towards a mutation in every gene in Caenorhabditis elegans. Brief Funct Genomic Proteomic 7:195-204, 2008. [Abstract]

Qiu C, Zeyda T, Johnson B, Hochgeschwender U, de Lecea L, Tallent MK. Somatostatin receptor subtype 4 couples to the M-current to regulate seizures. J Neurosci 28:3567-3576, 2008. [Abstract]

Vorozhko VV, Emanuele MJ, Kallio MJ, Stukenberg PT, Gorbsky GJ. Multiple mechanisms of chromosome movement in vertebrate cells mediated through the Ndc80 complex and dynein/dynactin. Chromosoma 117:169-179, 2008. [Abstract]

Zeyda T, Hochgeschwender U. Null mutant mouse models of somatostatin and cortistatin, and their receptors. Mol Cell Endocrinol 286:18-25, 2008. [Abstract]

Protein Studies Research Program

Ghosh AK, Gemma S, Tang J. Beta-secretase as a therapeutic target for Alzheimer’s disease. Neurotherapeutics 5:399-408, 2008. [Abstract]

Ghosh AK, Kumaragurubaran N, Hong L, Koelsh G, Tang J. Memapsin 2 (beta-secretase) inhibitors: drug development. Curr Alzheimer Res 5:121-131, 2008. [Abstract]

Ghosh AK, Kumaragurubaran N, Hong L, Kulkarni S, Xu X, Miller HB, Reddy DS, Weerasena V, Turner R, Chang W, Koelsch G, Tang J. Potent memapsin 2 (beta-secretase) inhibitors: design, synthesis, protein-ligand X-ray structure, and in vivo evaluation. Bioorg Med Chem Lett 18:1031-1036, 2008. [Abstract]

Li X, Lou Z, Li X, Zhou W, Ma M, Cao Y, Geng Y, Bartlam M, Zhang XC, Rao Z. Structure of human cytosolic X-prolyl aminopeptidase: a double Mn(II)-dependent dimeric enzyme with a novel three-domain subunit. J Biol Chem 283:22858-22866, 2008. [Abstract]

Zhang R, Zhu G, Zhang W, Cao S, Ou X, Li X, Bartlam M, Xu Y, Zhang XC, Rao Z. Crystal structure of a carbonyl reductase from Candida parapsilosis with anti-Prelog stereospecificity. Protein Sci 17:1412-1423, 2008. [Abstract]

* Indicates publications by more than one department.

04/08/10

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