2007 Scientific Publications

Arthritis and Immunology Research Program

Alex P, Szodoray P, Knowlton N, Dozmorov IM, Turner M, Frank MB, Arthur RE, Willis L, Flinn D, Hynd RF, Carson C, Kumar A, El-Gabalawy HS, Centola M. Multiplex serum cytokine monitoring as a prognostic tool in rheumatoid arthritis. Clin Exp Rheumatol 25:584-592, 2007. [Abstract]

Alex P, Szodoray P, Arthur E, Willis L, Hynd R, Flinn D, Centola M. Influence of intraarticular corticosteroid administration on serum cytokines in rheumatoid arthritis. Clin Rheumatol 25:845-848, 2007. [Abstract]

Ali T, Greenfield RA, Scofield H, Bronze MS. Gatifloxacin-associated hypoglycemia. J Okla State Med Assoc 100:425-428, 2007. [Abstract]

Beiraghi S, Nath SK, Gaines M, Mandhyan DD, Hutchings D, Ratnamala U, McElreavey K, Bartoloni L, Antonarakis GS, Antonarakis SE, Radhakrishna U. Autosomal dominant nonsyndromic cleft lip and palate: significant evidence of linkage at 18q21.1. Am J Hum Genet 81:180-188, 2007. [Abstract]

Blevins SM, Leyva MJ, Brown J, Wright J, Scofield RH, Aston CE.  Effect of cinnamon on glucose and lipid levels in non-insulin dependent type 2 diabetes. Diabetes Care 30:2236-2237, 2007. [Abstract]

Bouali H, Nietert P, Nowling TM, Pandey J, Dooley MA, Cooper G, Harley J, Kamen DL, Oates J, Gilkeson G. Association of the G-463A myeloperoxidase gene polymorphism with renal disease in African Americans with systemic lupus erythematosus. J Rheumatol 34:2028-2034, 2007. [Abstract]

Casellas R, Zhang Q, Zheng NY, Mathias MD, Smith K, Wilson PC. Igkappa allelic inclusion is a consequence of receptor editing. J Exp Med 204:153-160, 2007. [Abstract] [Abstract]

* Chung CH, Kurien BT, Mehta P, Mhatre M, Mou S, Pye QN, Stewart C, West M, Williamson KS, Post J, Liu L, Wang R, Hensley K. Identification of lanthionine synthase C-like protein-1 as a prominent glutathione binding protein expressed in the mammalian central nervous system. Biochemistry 46:3262-3269, 2007.

Crouch EE, Li Z, Takizawa M, Fichtner-Feigl S, Gourzi P, Montano C, Feigenbaum L, Wilson P, Janz S, Papavasiliou FN, Casellas R. Regulation of AID expression in the immune response. J Exp Med 204:1145-1156, 2007. [Abstract] [Abstract]

Dorri Y, Sabeghi M, Kurien BT. Awaken olfactory receptors of humans and experimental animals by coffee odourants to induce appetite. Med Hypotheses 69:508-509, 2007.

Dozmorov MG, Kyker KD, Saban R, Shankar N, Baghdayan AS, Centola MB, Hurst RE. Systems biology approach for mapping the response of human uothelial cells to infection by Enterococcus faecalis. BMC Bioinformatics 8 Suppl 7:S2, 2007. [Abstract]

Dudek NL, Maier S, Chen ZJ, Mudd PA, Mannering SI, Jackson DC, Zeng W, Keech CL, Hamlin K, Pan ZJ, Davis-Schwarz K, Workman-Azbill J, Bachmann M, McCluskey J, Farris AD. T cell epitopes of the La/SSB autoantigen in humanized transgenic mice expressing the hLa class II haplotype DRB1*0301/DQB1*0201. Arthritis Rheum 56:3387-3398, 2007. [Abstract] [Abstract] [Abstract]

Gaeta BA, Malming HR, Jackson KJ, Bain ME, Wilson P, Collins AM. iHMMune-align: hidden Markov model-based alignment and identification of germline genes in rearranged immunoglobulin gene sequences. Bioinformatics 23:1580-1587, 2007.

George JN, Vesely SK , James JA. Overlapping features of thrombotic thrombocytopenic purpura and systemic lupus erythematosus. South Med J 100:512-514, 2007.

Gorelik G, Fang JY, Wu A, Sawalha AH, Richardson B. Impaired T cell protein kinase C{delta} activation decreases ERK pathway signaling in idiopathic and hydralazine-induced lupus. J Immunol 179:5553-5563, 2007. [Abstract]

Graham RR, Ortmann W, Rodine P, Espe K, Langefeld C, Lange E, Williams A, Beck S, Kyogoku C, Moser K, Gaffney P, Gregersen PK, Criswell LA, Harley JB, Behrens TW. Specific combinations of HLA-DR2 and DR3 class II haplotypes contribute graded risk for disease susceptibility and autoantibodies in human SLE. Eur J Hum Genet 15:823-830, 2007. [Abstract]

Harley JB. IL-7Ralpha and multiple sclerosis risk. Nat Genet 39:1053-1054, 2007. [Abstract]

* Heinlen LD, McClain MT, Merrill J, Akbarali YW, Edgerton CC, Harley JB, James JA. Clinical criteria for systemic lupus erythematosus precede diagnosis, and associated autoantibodies are present before clinical symptoms. Arthritis Rheum 56:2344-2351, 2007. [Abstract]

Hirakata M, Suwa A, Takada T, Sato S, Nagai S, Genth E, Song YW, Mimori T, Targoff IN. Clinical and immunogenetic features of patients with autoantibodies to asparaginyl-transfer RNA synthetase. Arthritis Rheum 56:1295-1303, 2007. [Abstract]

Jackson SM, Harp N, Patel D, Henderson M, Roy NM, Courtney MA, Johnson A, Capra JD. CD45RO: A marker for BCR-mediated selection. Scand J Immunol 66:249-260, 2007. [Abstract]

Jackson SM, Harp N, Patel D, Zhang J, Willson S, Kim YJ, Clanton C, Capra JD. CD45RO enriches for activated, highly mutated human germinal center B cells. Blood 110:3917-3925, 2007. [Abstract]

* James J, Kim-Howard X, Bruner B, Jonsson M, McClain M, Arbuckle M, Walker C, Dennis G, Merrill J, Harley J. Hydroxychloroquine sulfate treatment is associated with later onset of systemic lupus erythematosus. Lupus 16:401-409, 2007. [Abstract]

Jarvis JN, Jiang K, Petty HR, Centola M. Neutrophils: the forgotten cell in JIA disease pathogenesis. Pediatr Rheumatol Online J 5:13, 2007. [Abstract]

Katzav A, Solodeev I, Brodsky O, Chapman J, Pick CG, Blank M, Zhang W, Reichlin M, Shoenfeld Y. Induction of autoimmune depression in mice by anti-ribosomal P antibodies via the limbic system. Arthritis Rheum 56:938-948, 2007. [Abstract]

Koelsch K, Zheng NY, Zhang Q, Duty A, Helms C, Mathias MD, Jared M, Smith K, Capra JD, Wilson PC. Mature B cells class switched to IgD are autoreactive in healthy individuals. J Clin Invest 117:1558-65, 2007. [Abstract]

Koenig M, Fritzler MJ, Targoff IN, Troyanov Y, Senecal JL. Heterogeneity of autoantibodies in 100 patients with autoimmune myositis: insights into clinical features and outcomes. Arthritis Res Ther 9:R78, 2007. [Abstract]

Kurien BT. Reply to ‘PH paper trumps expensive kits in measuring acidity’. Nat Med 13:1275, 2007.

Kurien BT, Dorri Y, D’Souza A, Scofield RH. Four men in a space station – To say nothing of the cow! The quest for finding respite and work in the ultimate frontier. Med Hypotheses 68:1195-9,  2007. [Abstract]

Kurien BT, Mathews SA, Scofield RH. Can low dose diagnostic dental radiation trigger Sjogren’s syndrome? Med Hypotheses 69:995-1000, 2007. [Abstract]

Kurien BT, Scofield RH. Curcumin/turmeric solubilized in sodium hydroxide inhibits HNE protein modification-An in vitro study. J Ethnopharmacol 110:368-73, 2007. [Abstract]

Kurien BT, Singh A, Matsumoto H, Scofield RH. Improving the solubility and pharmacological efficacy of curcumin by heat treatment. Assay Drug Dev Technol 5:567-576, 2007. [Abstract]

Lawrence S, Tang Y, Frank MB, Dozmorov I, Jiang K, Chen Y, Cadwell C, Turner S, Centola M, Jarvis JN. A dynamic model of gene expression in monocytes reveals differences in immediate/early response genes between adult and neonatal cells. J Inflamm (Lond) 4:4, 2007. [Abstract]

Lee YH, Ota F, Kim-Howard X, Kaufman KM, Nath SK. APRIL polymorphism and systemic lupus erythematosus (SLE) susceptibility. Rheumatology (Oxford) 46:1274-1276, 2007. [Abstract]

Lee YH, Rho YH, Choi SJ, Ji JD, Song GG, Nath SK, Harley JB. The PTPN22 C1858T functional polymorphism and autoimmune diseases–a meta-analysis. Rheumatology (Oxford) 46:49-56, 2007. [Abstract]

Lu K, Zhou Y, Kaufman K, Mott R, Ma JX. Rat strain-dependent susceptibility to ischemia-induced retinopathy associated with retinal vascular endothelial growth factor regulation. J Mol Endocrinol 38:423-432, 2007. [Abstract]

Maier SM, Gross JK, Hamlin KL, Maier JL, Workman JL, Kim-Howard XR, Schoeb TR, Farris AD. Proteinuria of nonautoimmune origin in wild-type FVB/NJ mice. Comp Med 57:255-266, 2007. [Abstract]

Mandhyan DD, Kim-Howard X, Gaines M, Nath SK. A genome-wide ordered-subset linkage analysis for rheumatoid arthritis. BMC Proc 1 Suppl 1:S101, 2007. [Abstract]

Malik S, Bruner GR, Williams-Weese C, Feo L, Scofield RH, Reichlin M, Harley JB, Sawalha AH. Presence of anti-La autoantibody is associated with a lower risk of nephritis and seizures in lupus patients. Lupus 16:863-866, 2007. [Abstract]

Namjou B, Kilpatrick J, Harley JB. Genetics of clinical expression in SLE. Autoimmunity 40:602-612, 2007. [Abstract]

Naveed M, Nath SK, Gaines M, Al-Ali MT, Al-Khaja N, Hutchings D, Golla J, Deutsch S, Bottani A, Antonarakis SE, Ratnamala U, Radhakrishna U. Genomewide linkage scan for split-hand/foot malformation with long-bone deficiency in a large Arab family identifies two novel susceptibility loci on chromosomes 1q42.2-q43 and 6q14.1. Am J Hum Genet 80:105-111, 2007. [Abstract]

Niewold TB, Hua J, Lehman TJ, Harley JB, Crow MK. High serum IFN-alpha activity is a heritable risk factor for systemic lupus erythematosus. Genes Immun 8:492-502, 2007. [Abstract]

Pham T, Cornea A, Blick KE, Jenkins A, Scofield RH. Oral glucosamine in doses used to treat osteoarthritis worsens insulin resistance. Am J Med Sci 333:333-339, 2007. [Abstract]

Pham T, Scofield RH. 13-cis-Retinoic acid (isotretinoin) unmasking of clinical polycystic ovary syndrome. Endocr Pract 13:776-779, 2007. [Abstract]

Rinderknecht CH, Belmares MP, Catanzarite TL, Bankovich AJ, Holmes TH, Garcia KC, Nanda NK, Busch R, Kovats S, Mellins ED. Posttranslational regulation of I-Ed by affinity for CLIP. J Immunol 179:5907-5915, 2007. [Abstract]

Saban R, D’Andrea MR, Andrade-Gordon P, Derian CK, Dozmorov I, Ihnat MA, Hurst RE, Simpson C, Saban MR. Regulatory network of inflammation downstream of proteinase-activated receptors. BMC Physiol 7:3, 2007. [Abstract]

Saban R, D’Andrea MR, Andrade-Gordon P, Derian CK, Dozmorov I, Ihnat MA, Hurst RE, Davis CA, Simpson C, Saban MR. Mandatory role of proteinase-activated receptor 1 in experimental bladder inflammation. BMC Physiol 7:4, 2007. [Abstract]

Saban R, Simpson C, Davis CA, Dozmorov I, Maier J, Fowler B, Ihnat MA, Hurst RE, Wershil BK, Saban MR. Transcription factor network downstream of protease activated receptors (PARs) modulating mouse bladder inflammation. BMC Immunol 8:17, 2007. [Abstract]

Saban MR, Simpson C, Davis CA, Wallis G, Knowlton N, Frank MB, Centola M, Gallucci RM, Saban R. Discriminators of mouse bladder response to intravesical Bacillus Calmette-Guerin (BCG). BMC Immunol 8:6, 2007. [Abstract]

Sawalha AH, Jeffries M. Defective DNA methylation and CD70 overexpression in CD4+ T cells in MRL/lpr lupus-prone mice. Eur J Immunol 37:1407-1413, 2007. [Abstract]

Scofield RH, Bruner GR, Harley JB, Namjou B. Autoimmune thyroid disease is associated with a diagnosis of secondary Sjogren’s syndrome in familial systemic lupus. Ann Rheum Dis66:410-3, 2007. [Abstract]

Semsei I, Maier S, Workman-Azbill J, Urban L, Moser K, Zeher M, Bachmann M, Farris AD. Detection of a rare oligo(A) repeat tract mutation (8As–>7As) in the sequence encoding the La/SS-B autoantigen. Anal Biochem 370:47-53, 2007.  [Abstract]

Sestak AL, Nath SK , Sawalha AH, Harley JB. Current status of lupus genetics. Arthritis Res Ther 9:210, 2007. [Abstract]

Sestak A, O’Neil K. Review: Familial lupus and antiphospholipid syndrome. Lupus 16:556-563, 2007. [Abstract]

* Shankar M, Nixon JC, Maier S, Workman J, Farris AD, Webb CF. Anti-nuclear antibody production and autoimmunity in transgenic mice that overexpress the transcription factor Bright. J Immunol 178:2996-3006, 2007. [Abstract]

Szodoray P, Alex P, Chappell-Woodward CM, Madland TM, Knowlton N, Dozmorov I, Zeher M, Jarvis JN, Nakken B, Brun JG, Centola M. Circulating cytokines in Norwegian patients with psoriatic arthritis determined by a multiplex cytokine array system. Rheumatology (Oxford) 46:417-425, 2007.  [Abstract]

Teague BN, Pan Y, Mudd PA, Nakken B, Zhang Q, Szodoray P, Kim-Howard X, Wilson PC, Farris AD. Cutting edge: Transitional T3 B cells do not give rise to mature B cells, have undergone selection, and are reduced in murine lupus. J Immunol 178:7511-7515, 2007. [Abstract]

* Van Komen JS, Mishra S, Byrum J, Chichili GR, Yaciuk JC, Farris AD, Rodgers W. Early and dynamic polarization of T cell membrane rafts and constituents prior to TCR stop signals. J Immunol 179:6845-6855, 2007. [Abstract]

Williams PH, Cobb BL, Namjou B, Scofield RH, Sawalha AH, Harley JB. Horizons in Sjögren’s syndrome genetics. Clin Rev Allergy Immunol 32:201-209, 2007. [Abstract]

Wren JD, Wu Y, Guo SW. A system-wide analysis of differentially expressed genes in ectopic and eutopic endometrium. Hum Reprod 22:2093-2102, 2007. [Abstract]

Wren JD, Kozak KZ, Johnson KR, Deakyne SJ, Schilling LM, Dellavalle RP. The write position. A survey of perceived contributions to papers based on byline position and number of authors. EMBO Rep 8:988-991, 2007. [Abstract]

Xing C, Sestak AL, Kelly JA, Nguyen KL, Bruner GR, Harley JB, Gray-McGuire C. Localization and replication of the systemic lupus erythematosus linkage signal at 4p16: interaction with 2p11, 12q24 and 19q13 in European Americans. Hum Genet 120:623-31, 2007. [Abstract]

* Zhu H, Tang Y, Ivanciu L, Centola M, Lupu C, Taylor FB, Jr., Lupu F. Temporal dynamics of gene expression in the lung in a baboon model of E. coli sepsis. BMC Genomics 8:58, 2007. [Abstract] [Abstract]

Cardiovascular Biology Research Program

An G, Wei B, Xia B, McDaniel JM, Ju T, Cummings RD, Braun J, Xia L. Increased susceptibility to colitis and colorectal tumors in mice lacking core 3-derived O-glycans. J Exp Med 204:1417-1429, 2007.

Binette TM, Taylor FB, Jr., Peer G, Bajzar L. Thrombin-thrombomodulin connects coagulation and fibrinolysis: more than an in vitro phenomenon. Blood 110:3168-3175, 2007. [Abstract]

Borgel D, Bornstain C, Reitsma PH, Lerolle N, Gandrille S, Dali-Ali F, Esmon CT, Fagon JY, Aiach M, Diehl JL. A Comparative study of the protein C pathway in septic and non-septic patients with organ failure. Am J Respir Crit Care Med 176:878-885, 2007. [Abstract]

Chichili GR, Rodgers W. Clustering of membrane raft proteins by the actin cytoskeleton. J Biol Chem 282:36682-36691, 2007. [Abstract]

* Condac E, Silasi-Mansat R, Kosanke S, Schoeb T, Towner R, Lupu F, Cummings RD, Hinsdale ME. Polycystic disease caused by deficiency in xylosyltransferase 2, an initiating enzyme of glycosaminoglycan biosynthesis. Proc Natl Acad Sci U S A 104:9416-9421, 2007. [Abstract]

Cuellar K, Chuong H, Hubbell SM, Hinsdale ME. Biosynthesis of chondroitin and heparan sulfate in chinese hamster ovary cells depends on xylosyltransferase II. J Biol Chem 282:5195-5200, 2007.[Abstract]

Gao HK, Zhou ZG, Li Y, Chen YQ. Toll-like receptor 4 Asp299Gly polymorphism is associated with an increased risk of pancreatic necrotic infection in acute pancreatitis: a study in the Chinese population. Pancreas 34:295-298, 2007. [Abstract]

Ghosh S, Pendurthi UR, Esmon CT , Rao LV. Endothelial cell protein C receptor acts as a cellular receptor for factor VIIa on endothelium. J Biol Chem 282:11849-57, 2007. [Abstract]

Isermann B, Vinnikov IA, Madhusudhan T, Herzog S, Kashif M, Blautzik J, Corat MA, Zeier M, Blessing E, Oh J, Gerlitz B, Berg DT, Grinnell BW, Chavakis T, Esmon CT, Weiler H, Bierhaus A, Nawroth PP. Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis. Nat Med 13:1349-1358, 2007. [Abstract]

Ivanciu L, Gerard RD, Tang H, Lupu F, Lupu C. Adenovirus-mediated expression of tissue factor pathway inhibitor-2 Inhibits endothelial cell migration and angiogenesis. Arterioscler Thromb Vasc Biol 27:310-316, 2007.[Abstract]

Kashiwagi A, Digirolamo CM, Kanda Y, Niikura Y, Esmon CT, Hansen TR, Shioda T, Pru JK. The postimplantation embryo differentially regulates endometrial gene expression and decidualization. Endocrinology 148:4173-84, 2007. [Abstract]

McEver RP, Zhu C. A catch to integrin activation. Nat Immunol 8:1035-1037, 2007. [Abstract] [Abstract] [Abstract] [Abstract]

Miner J, Hoffhines A. The discovery of aspirin’s antithrombotic effects. Tex Heart Inst J 34:179-186, 2007.

Oettinger CM, D’souza MJ, Akhavein N, Peer GT, Taylor FB, Kinasewitz GT. Pro-inflammatory cytokine inhibition in the primate using microencapsulated antisense oligomers to NF-kappaB. J Microencapsul 24:337-348, 2007.

Qu D, Wang Y, Esmon NL, Esmon CT. Regulated endothelial protein C receptor shedding is mediated by tumor necrosis factor-alpha converting enzyme/ADAM17. J Thromb Haemost 5:395-402, 2007.

Samis JA, Stewart KA, Nesheim ME, Taylor FB, Jr. Factor V Cleavage and inactivation are temporally associated with elevated elastase during experimental sepsis. J Thromb Haemost 5:2559-2561, 2007. [Abstract]

Silverstein RL, Bauer KA, Cushman M, Esmon CT, Ershler WB, Tracy RP. Venous thrombosis in the elderly: more questions than answers. Blood 110:3097-3101, 2007. [Abstract]

Stowell SR, Karmakar S, Stowell CJ, Dias-Baruffi M, McEver RP, Cummings RD. Human galectin-1, -2, and -4 induce surface exposure of phosphatidylserine in activated human neutrophils but not activated T cells. Blood 109:219-27,  2007. [Abstract]

Tang H, Ivanciu L, Popescu N, Peer G, Hack E, Lupu C, Taylor FB, Jr., Lupu F. Sepsis-induced coagulation in the baboon lung is associated with decreased tissue factor pathway inhibitor. Am J Pathol 171:1066-1077, 2007.  [Abstract]

* Towner RA, Smith N, Tesiram YA, Abbott A, Saunders D, Blindauer R, Herlea O, Silasi-Mansat R, Lupu F. In vivo detection of c-MET expression in a rat hepatocarcinogenesis model using molecularly targeted magnetic resonance imaging. Mol Imaging 6:18-29, 2007. [Abstract]

* Van Komen JS, Mishra S, Byrum J, Chichili GR, Yaciuk JC, Farris AD, Rodgers W. Early and dynamic polarization of T cell membrane rafts and constituents prior to TCR stop signals. J Immunol 179:6845-6855, 2007. [Abstract]

Williams SA, Xia L, Cummings RD, McEver RP, Stanley P. Fertilization in mouse does not require terminal galactose or N-acetylglucosamine on the zona pellucida glycans. J Cell Sci 120:1341-9, 2007. [Abstract]

Yago T, Zarnitsyna VI, Klopocki AG, McEver RP, Zhu C. Transport governs flow-enhanced cell tethering through L-selectin at threshold shear. Biophys J 92:330-42,  2007. [Abstract]

Yu Y, Hoffhines AJ, Moore KL, Leary JA. Determination of the sites of tyrosine O-sulfation in peptides and proteins. Nat Methods 4:583-588, 2007. [Abstract]

Zheng X, Li W, Gu JM, Qu D, Ferrell GL, Esmon NL, Esmon CT. Effects of membrane and soluble EPCR on the hemostatic balance and endotoxemia in mice. Blood 109:1003-9, 2007.[Abstract]

Zheng X, Li W, Song Y, Hu Y, Ferrell GL, Esmon NL, Esmon CT. Non-hematopoietic EPCR regulates the coagulation and inflammatory responses during endotoxemia. J Thromb Haemost 5:1394-400, 2007. [Abstract]

* Zhu H, Tang Y, Ivanciu L, Centola M, Lupu C, Taylor FB, Jr., Lupu F. Temporal dynamics of gene expression in the lung in a baboon model of E. coli sepsis. BMC Genomics 8:58, 2007. [Abstract]

Zwerts F, Lupu F, De VA, Pollefeyt S, Moons L, Altura RA, Jiang Y, Maxwell PH, Hill P, Oh H, Rieker C, Collen D, Conway SJ, Conway EM. Lack of endothelial cell survivin causes embryonic defects in angiogenesis, cardiogenesis, and neural tube closure. Blood 109:4742-4752, 2007. [Abstract]

Clinical Pharmacology Research Program

Hanly JG, Urowitz MB, Sanchez-Guerrero J, Bae SC, Gordon C, Wallace DJ, Isenberg D, Alarcon GS, Clarke A, Bernatsky S, Merrill JT, Petri M, Dooley MA, Gladman D, Fortin PR, Steinsson K, Bruce I, Manzi S, Khamashta M, Zoma A, Aranow C, Ginzler E, van VR, Font J, Sturfelt G, Nived O, Ramsey-Goldman R, Kalunian K, Douglas J, Thompson K, Farewell V. Neuropsychiatric events at the time of diagnosis of systemic lupus erythematosus: an international inception cohort study. Arthritis Rheum 56:265-273, 2007. [Abstract]

* Heinlen LD, McClain MT, Merrill J, Akbarali YW, Edgerton CC, Harley JB, James JA. Clinical criteria for systemic lupus erythematosus precede diagnosis, and associated autoantibodies are present before clinical symptoms. Arthritis Rheum 56:2344-2351, 2007. [Abstract]

* James J, Kim-Howard X, Bruner B, Jonsson M, McClain M, Arbuckle M, Walker C, Dennis G, Merrill J, Harley J. Hydroxychloroquine sulfate treatment is associated with later onset of systemic lupus erythematosus. Lupus 16:401-409, 2007. [Abstract]

Urowitz MB, Gladman D, Ibanez D, Fortin P, Sanchez-Guerrero J, Bae S, Clarke A, Bernatsky S, Gordon C, Hanly J, Wallace D, Isenberg D, Ginzler E, Merrill J, Alarcon G, Steinsson K, Petri M, Dooley MA, Bruce I, Manzi S, Khamashta M, Ramsey-Goldman R, Zoma A, Sturfelt G, Nived O, Maddison P, Font J, van VR, Aranow C, Kalunian K, Stoll T, Buyon J. Clinical manifestations and coronary artery disease risk factors at diagnosis of systemic lupus erythematosus: data from an international inception cohort. Lupus 16:731-735, 2007. [Abstract]

Comparative Medicine

Gruber HE, Gordon B, Williams C, Norton HJ, Hanley EN, Jr. Vertebral endplate and disc changes in the aging sand rat lumbar spine: cross-sectional analyses of a large male and female population. Spine 32:2529-2536, 2007. [Abstract]

Crystallography Research Program

Cao S, Lou Z, Tan M, Chen Y, Liu Y, Zhang Z, Zhang XC, Jiang X, Li X, Rao Z. Structural basis for the recognition of blood group trisaccharides by norovirus. J Virol 81:5949-5957, 2007. [Abstract]

Chvyrkova I, Zhang XC, Terzyan S. Lethal factor of anthrax toxin binds monomeric form of protective antigen. Biochem Biophys Res Commun 360:690-695, 2007. [Abstract]

Vallas V, Farrugia W, Raison RL, Edmundson AB, Ramsland PA. Dissimilar aggregation processes govern precipitation and gelation of human IgM cryoglobulins. J Mol Recognit 20:90-96, 2007. [Abstract]

Wang L, Cowley AB, Terzyan S, Zhang X, Benson DR. Comparison of cytochromes b5 from insects and vertebrates. Proteins 67:293-304, 2007. [Abstract]

Zhu G, Chen J, Liu J, Brunzelle JS, Huang B, Wakeham N, Terzyan S, Li X, Rao Z, Li G, Zhang XC. Structure of the APPL1 BAR-PH domain and characterization of its interaction with Rab5. EMBO J 26:3484-3493, 2007. [Abstract]

Zhu H, Zhu G, Liu J, Liang Z, Zhang XC, Li G. Rabaptin-5-independent membrane targeting and Rab5 activation by Rabex-5 in the cell. Mol Biol Cell 18:4119-4128, 2007. [Abstract]

Free Radical Biology and Aging Research Program

Ancha HR, Kurella RR, Stewart CA, Damera G, Ceresa BP, Harty RF. Histamine stimulation of MMP-1(Collagenase-1) secretion and gene expression in gastric epithelial cells: role of EGFR transactivation and the MAP kinase pathway. Int J Biochem Cell Biol 39:2143-2152, 2007. [Abstract]

Arimoto T, Choi DY, Lu X, Liu M, Nguyen XV, Zheng N, Stewart CA, Kim HC, Bing G. Interleukin-10 protects against inflammation-mediated degeneration of dopaminergic neurons in substantia nigra. Neurobiol Aging 28:894-906, 2007. [Abstract]

* Chung CH, Kurien BT, Mehta P, Mhatre M, Mou S, Pye QN, Stewart C, West M, Williamson KS, Post J, Liu L, Wang R, Hensley K. Identification of lanthionine synthase C-like protein-1 as a prominent glutathione binding protein expressed in the mammalian central nervous system. Biochemistry 46:3262-3269, 2007. [Abstract]

* Condac E, Silasi-Mansat R, Kosanke S, Schoeb T, Towner R, Lupu F, Cummings RD, Hinsdale ME. Polycystic disease caused by deficiency in xylosyltransferase 2, an initiating enzyme of glycosaminoglycan biosynthesis. Proc Natl Acad Sci U S A 104:9416-9421, 2007. [Abstract]

Inoue Y, Asanuma T, Smith N, Saunders D, Oblander J, Kotake Y, Floyd RA, Towner RA. Modulation of Fas-FasL related apoptosis by PBN in the early phases of choline deficient diet-mediated hepatocarcinogenesis in rats. Free Radic Res 41:972-980, 2007. [Abstract]

Kopke RD , Jackson RL, Coleman JK, Liu J, Bielefeld EC, Balough BJ. NAC for noise: From the bench top to the clinic. Hear Res 226:114-125, 2007. [Abstract]

Matsuzaki S, Szweda LI. Inhibition of complex I by Ca(2+) reduces electron transport activity and the rate of superoxide anion production in cardiac submitochondrial particles. Biochemistry 46:1350-1357, 2007. [Abstract]

McMeekin DS, Sill MW, Benbrook D, Darcy KM, Stearns-Kurosawa DJ, Eaton L, Yamada SD. A phase II trial of thalidomide in patients with refractory endometrial cancer and correlation with angiogenesis biomarkers: a Gynecologic Oncology Group study. Gynecol Oncol 105:508-16, 2007. [Abstract]

Miller RA, Harrison DE, Astle CM, Floyd RA, Flurkey K, Hensley KL, Javors MA, Leeuwenburgh C, Nelson JF, Ongini E, Nadon NL, Warner HR, Strong R. An aging interventions testing program: study design and interim report. Aging Cell 6:565-575, 2007. [Abstract]

Moreira PI, Siedlak SL, Wang X, Santos MS, Oliveira CR, Tabaton M, Nunomura A, Szweda LI, Aliev G, Smith MA, Zhu X, Perry G. Autophagocytosis of mitochondria is prominent in Alzheimer disease. J Neuropathol Exp Neurol 66:525-532, 2007. [Abstract]

Moreira PI, Siedlak SL, Wang X, Santos MS, Oliveira CR, Tabaton M, Nunomura A, Szweda LI, Aliev G, Smith MA, Zhu X, Perry G. Increased autophagic degradation of mitochondria in Alzheimer disease. Autophagy 3:614-615, 2007. [Abstract]

Oktay Y, Dioum E, Matsuzaki S, Ding K, Yan LJ, Haller RG, Szweda LI, Garcia JA. Hypoxia inducible factor 2 alpha regulates expression of the mitochondrial aconitase chaperone protein frataxin. J Biol Chem 282:11750-6, 2007. [Abstract]

Saban MR, Towner R, Smith N, Abbott A, Neeman M, Davis CA, Simpson C, Maier J, Memet S, Wu XR, Saban R. Lymphatic vessel density and function in experimental bladder cancer. BMC Cancer 7:219, 2007. [Abstract]

Towner RA, Smith N, Tesiram YA, Abbott A, Saunders D, Blindauer R, Herlea O, Silasi-Mansat R, Lupu F. In vivo detection of c-MET expression in a rat hepatocarcinogenesis model using molecularly targeted magnetic resonance imaging. Mol Imaging 6:18-29, 2007. [Abstract]

Yu X, Tesiram YA, Towner RA, Abbott A, Patterson E, Huang S, Garrett MW, Chandrasekaran S, Matsuzaki S, Szweda LI, Gordon BE, Kem DC. Early myocardial dysfunction in streptozotocin-induced diabetic mice: a study using in vivo magnetic resonance imaging (MRI). Cardiovasc Diabetol 6:6, 2007. [Abstract]

Immunobiology and Cancer Research Program

Berggren MA, Heinlen L, Isaksson A, Nystrom U, Ricksten A. EBNA1 expression in a lung transplant recipient with hypocomplementemic urticarial vasculitis syndrome. J Med Virol 79:963-969, 2007. [Abstract]

Chakrabarty K, Wu W, Booth JL, Duggan ES, Nagle NN, Coggeshall KM, Metcalf JP. Human lung innate immune response to Bacillus anthracis spore infection. Infect Immun 75:3729-3738, 2007. [Abstract]

Eckle T, Krahn T, Grenz A, Kohler D, Mittelbronn M, Ledent C, Jacobson MA, Osswald H, Thompson LF, Unertl K, Eltzschig HK. Cardioprotection by ecto-5′-nucleotidase (CD73) and A2B adenosine receptors. Circulation 115:1581-1590, 2007. [Abstract]

Grenz A, Zhang H, Eckle T, Mittelbronn M, Wehrmann M, Kohle C, Kloor D, Thompson LF, Osswald H, Eltzschig HK. Protective role of ecto-5′-nucleotidase (CD73) in renal ischemia. J Am Soc Nephrol 18:833-845, 2007. [Abstract]

Hardy RR, Kincade PW, Dorshkind K. The protean nature of cells in the B lymphocyte lineage. Immunity 26:703-714, 2007. [Abstract]

Kolar GR, Mehta D, Pelayo R, Capra JD. A novel human B cell subpopulation representing the initial germinal center population to express AID. Blood 109:2545-52, 2007. [Abstract]

Montesinos MC, Takedachi M, Thompson LF, Wilder TF, Fernandez P, Cronstein BN. The antiinflammatory mechanism of methotrexate depends on extracellular conversion of adenine nucleotides to adenosine by ecto-5′-nucleotidase: findings in a study of ecto-5′-nucleotidase gene-deficient mice. Arthritis Rheum 56:1440-1445, 2007. [Abstract]

Perry SS, Zhao Y, Nie L, Cochrane SW, Huang Z, Sun XH. Id1, but not Id3, directs long-term repopulating hematopoietic stem-cell maintenance. Blood 110:2351-2360, 2007. [Abstract]

* Shankar M, Nixon JC, Maier S, Workman J, Farris AD, Webb CF. Anti-nuclear antibody production and autoimmunity in transgenic mice that overexpress the transcription factor Bright. J Immunol 178:2996-3006, 2007. [Abstract]

Welner RS, Kincade PW. Stem cells on patrol. Cell 131:842-844, 2007. [Abstract]

Welner RS, Pelayo R, Garrett KP, Chen X, Perry SS, Sun XH, Kee BL, Kincade PW. Interferon-producing killer dendritic cells (IKDCs) arise via a unique differentiation pathway from primitive c-kitHiCD62L+ lymphoid progenitors. Blood 109:4825-4931, 2007. [Abstract]

Lipid and Lipoprotein Laboratory

Hilpert KF, West SG, Kris-Etherton PM, Hecker KD, Simpson NM, Alaupovic P. Postprandial effect of n-3 polyunsaturated fatty acids on apolipoprotein B-containing lipoproteins and vascular reactivity in type 2 diabetes. Am J Clin Nutr 85:369-376, 2007. [Abstract]

Molecular, Cell and Developmental Biology Research Program

Chen J, Reyes M, Clarke M, Shuman HA. Host cell-dependent secretion and translocation of the LepA and LepB effectors of Legionella pneumophila. Cell Microbiol 9:1660-1671, 2007. [Abstract]

Conchello JA, Dresser ME. Extended depth-of-focus microscopy via constrained deconvolution. J Biomed Opt 12:064026, 2007. [Abstract]

Conrad MN, Lee CY, Wilkerson JL, Dresser ME. MPS3 mediates meiotic bouquet formation in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 104:8863-8868, 2007. [Abstract]

Jung N, Wienisch M, Gu M, Rand JB, Muller SL, Krause G, Jorgensen EM, Klingauf J, Haucke V. Molecular basis of synaptic vesicle cargo recognition by the endocytic sorting adaptor stonin 2. J Cell Biol 179:1497-1510, 2007. [Abstract]

Karpac J, Kern A, Hochgeschwender U. Pro-opiomelanocortin peptides and the adrenal gland. Mol Cell Endocrinol 265-266:29-33, 2007. [Abstract]

Luke CJ, Pak SC, Askew YS, Naviglia TL, Askew DJ, Nobar SM, Vetica AC, Long OS, Watkins SC, Stolz DB, Barstead RJ, Moulder GL, Bromme D, Silverman GA. An intracellular serpin regulates necrosis by inhibiting the induction and sequelae of lysosomal Injury. Cell 130:1108-1119, 2007. [Abstract]

Mathews EA, Mullen GP, Crowell JA, Duerr JS, McManus JR, Duke A, Gaskin J, Rand JB. Differential expression and function of synaptotagmin 1 isoforms in Caenorhabditis elegans. Mol Cell Neurosci 34:642-652, 2007. [Abstract]

Mullen GP, Mathews EA, Vu MH, Hunter JW, Frisby DL, Duke A, Grundahl K, Osborne JD, Crowell JA, Rand JB. Choline transport and de novo choline synthesis support acetylcholine biosynthesis in Caenorhabditis elegans cholinergic neurons. Genetics 177:195-204, 2007. [Abstract]

Nguyen K, van D, I, Grundahl KM, Kawar ZS, Cummings RD. Molecular cloning and characterization of the Caenorhabditis elegans alpha1,3-fucosyltransferase family. Glycobiology 17:586-599, 2007. [Abstract]

Pablo-Hernando ME, Arnaiz-Pita Y, Nakanishi H, Dawson D, Del Rey F., Neiman AM, Vazquez de Aldana CR. Cdc15 is required for spore morphogenesis independently of Cdc14 in Saccharomyces cerevisiae. Genetics 177:281-293, 2007. [Abstract]

Pouwels J, Kukkonen AM, Lan W, Daum JR, Gorbsky GJ, Stukenberg T, Kallio MJ. Shugoshin 1 plays a central role in kinetochore assembly and is required for kinetochore targeting of Plk1. Cell Cycle 6:1579-1585, 2007. [Abstract]

Rand JB. Acetylcholine. WormBook 1-21, 2007. [Abstract]

Williams SL, Lutz S, Charlie NK, Vettel C, Ailion M, Coco C, Tesmer JJ, Jorgensen EM, Wieland T, Miller KG. Trio’s Rho-specific GEF domain is the missing G{alpha}q effector in C. elegans. Genes Dev 21:2731-2746, 2007. [Abstract]

Protein Studies Research Program

Chang WP, Downs D, Huang XP, Da H, Fung KM, Tang J. Amyloid-beta reduction by memapsin 2 (beta-secretase) immunization. FASEB J 21:3184-3196, 2007. [Abstract]

Ghosh AK, Bilcer G, Hong L, Koelsch G, Tang J. Memapsin 2 (beta-secretase) inhibitor drug, between fantasy and reality. Curr Alzheimer Res 4:418-422, 2007. [Abstract]

Ghosh AK, Kumaragurubaran N, Hong L, Kulkarni SS, Xu X, Chang W, Weerasena V, Turner R, Koelsch G, Bilcer G, Tang J. Design, synthesis, and X-ray structure of potent memapsin 2 (beta-secretase) inhibitors with isophthalamide derivatives as the P(2)(-)P(3)-ligands. J Med Chem 50:2399-2407, 2007. [Abstract]

He X, Cooley K, Chung CH, Dashti N, Tang J. Apolipoprotein Receptor 2 and X11{alpha}/{beta} Mediate apolipoprotein E-induced endocytosis of amyloid-{beta} precursor protein and {beta}-secretase, leading to amyloid-{beta} production. J Neurosci 27:4052-4060, 2007. [Abstract]

* Indicates publications by more than one department.

01/13/10