2006 Scientific Publications

Arthritis and Immunology Research Program

Addington S, Larson N, Scofield RH. Milk-alkali syndrome in pre-eclamptic pregnancy: report of a patient and evaluation of albumin-corrected calcium in pre-eclamptic pregnancies. J Okla State Med Assoc 99:480-484, 2006. [Abstract]

Akbarali Y, Matousek-Ronck J, Hunt L, Staudt L, Reichlin M, Guthridge JM, James JA. Fine specificity mapping of autoantigens targeted by anti-centromere autoantibodies. J Autoimmun 27:272-80, 2006. [Abstract]

Bachmann MP, Bartsch H, Gross JK, Maier SM, Gross TF, Workman JL, James JA, Farris AD, Jung B, Franke C, Conrad K, Schmitz M, Buttner C, Buyon JP, Semsei I, Harley JB, Rieber EP. Autoimmunity as a result of escape from RNA surveillance. J Immunol 177:1698-1707, 2006. [Abstract]

Beall DP, Henslee HB, Webb HR, Scofield RH. Milk-alkali syndrome: a historical review and description of the modern version of the syndrome. Am J Med Sci 331:233-242, 2006. [Abstract]

Centola M, Frank MB, Bolstad AI, Alex P, Szanto A, Zeher M, Hjelmervik TO, Jonsson R, Nakken B, Szegedi G, Szodoray P. Genome-scale assessment of molecular pathology in systemic autoimmune diseases using microarray technology: a potential breakthrough diagnostic and individualized therapy-design tool. Scand J Immunol 64:236-242, 2006. [Abstract]

Dozmorov MG, Kyker KD, Saban R, Knowlton N, Dozmorov I, Centola MB, Hurst RE. Analysis of the interaction of extracellular matrix and phenotype of bladder cancer cells. BMC Cancer 6:12, 2006. [Abstract]

Edwards CJ, James JA. Making lupus: a complex blend of genes and environmental factors is required to cross the disease threshold. Lupus 15:713-714, 2006. [Abstract]

Forabosco P, Gorman JD, Cleveland C, Kelly JA, Fisher SA, Ortmann WA, Johansson C, Johanneson B, Moser KL, Gaffney PM, Tsao BP, Cantor RM, Alarcon-Riquelme ME, Behrens TW, Harley JB, Lewis CM, Criswell LA. Meta-analysis of genome-wide linkage studies of systemic lupus erythematosus. Genes Immun 7:609-614, 2006. [Abstract]

Harley JB, Harley IT, Guthridge JM, James JA. The curiously suspicious: a role for Epstein-Barr virus in lupus. Lupus 15:768-777, 2006. [Abstract]

Harley JB, James JA. Epstein-barr virus infection induces lupus autoimmunity. Bull Hosp Jt Dis 64:45-50, 2006. [Abstract]

Harley JB, Kelly JA, Kaufman KM. Unraveling the genetics of systemic lupus erythematosus. Springer Semin Immunopathol 28:119-130, 2006. [Abstract]

James JA, Harley JB, Scofield RH. Epstein-Barr virus and systemic lupus erythematosus. Curr Opin Rheumatol 18:462-467, 2006. [Abstract]

Jarvis JN, Petty HR, Tang Y, Frank B, Tessier PA, Dozmorov I, Jiang K, Kindzelski A, Chen Y, Cadwell C, Turner M, McGhee JL, Centola M. Evidence for chronic, peripheral activation of neutrophils in polyarticular juvenile rheumatoid arthritis. Arthritis Res Ther 8:R154, 2006. [Abstract]

Kaufman KM, Kelly JA, Herring BJ, Adler AJ, Glenn SB, Namjou B, Frank SG, Dawson SL, Bruner GR, James JA, Harley JB. Evaluation of the genetic association of the PTPN22 R620W polymorphism in familial and sporadic systemic lupus erythematosus. Arthritis Rheum 54:2533-2540, 2006. [Abstract]

Kimm SY, Glynn NW, Obarzanek E, Aston CE, Daniels SR. Racial differences in correlates of misreporting of energy intake in adolescent females. Obes Res 14:156-164, 2006. [Abstract]

Knowlton N, Dozmorov I, Kyker KD, Saban R, Cadwell C, Centola MB, Hurst RE. Template-driven gene selection procedure. Syst Biol (Stevenage ) 153:4-12, 2006. [Abstract]

Kurien BT, Hensley K, Bachmann M, Scofield RH. Oxidatively modified autoantigens in autoimmune diseases. Free Radic Biol Med 41:549-556, 2006. [Abstract]

Kurien BT, Kurien JT. A possible animal model of naturally occurring multinodular goitre in the Nilgiris of southern India. Med J Aust 185:677, 2006. [Abstract]

Kurien BT, Patel NC, Porter AC, D’Souza A, Miller D, Matsumoto H, Wang H, Scofield RH. Prolidase deficiency and the biochemical assays used in its diagnosis. Anal. Biochem. 349:165-75, 2006.  [Abstract]

Kurien BT, Scofield RH. Autoantibody determination in the diagnosis of systemic lupus erythematosus. Scand J Immunol 64:227-235, 2006. [Abstract]

Kurien BT, Scofield RH. Lipid peroxidation in systemic lupus erythematosus. Indian J Exp Biol 44:349-356, 2006. [Abstract]

Kurien BT, Scofield RH. Western blotting. Methods 38:283-93, 2006. [Abstract]

Lee YH, Harley JB, Nath SK. Meta-analysis of TNF-alpha promoter -308 A/G polymorphism and SLE susceptibility. Eur J Hum Genet 14:364-71, 2006. [Abstract]

Li C, Tang Y, Li F, Turner S, Li K, Zhou X, Centola M, Yan X, Cao W. 17beta-estradiol (betaE(2)) protects human retinal Muller cell against oxidative stress in vitro: Evaluation of its effects on gene expression by cDNA microarray. Glia 53: 392-400, 2006 [Abstract]

Lyle R, Radhakrishna U, Blouin JL, Gagos S, Everman DB, Gehrig C, Delozier-Blanchet C, Solanki JV, Patel UC, Nath SK, Gurrieri F, Neri G, Schwartz CE, Antonarakis SE. Split-hand/split-foot malformation 3 (SHFM3) at 10q24, development of rapid diagnostic methods and gene expression from the region. Am J Med Genet A 140:1384-1395, 2006. [Abstract]

McClain MT, Poole BD, Bruner BF, Kaufman KM, Harley JB, James JA. An altered immune response to Epstein-Barr nuclear antigen 1 in pediatric systemic lupus erythematosus. Arthritis Rheum 54:360-368, 2006. [Abstract]

Mudd PA, Teague BN, Farris AD. Regulatory T cells and systemic lupus erythematosus. Scand J Immunol 64:211-218, 2006. [Abstract]

Naveed M, Al-Ali MT, Murthy SK, Al-Hajali S, Al-Khaja N, Deutsch S, Bottani A, Antonarakis SE, Nath SK, Radhakrishna U. Ectrodactyly with aplasia of long bones (OMIM; 119100) in a large inbred Arab family with an apparent autosomal dominant inheritance and reduced penetrance: Clinical and genetic analysis. Am J Med Genet A 140:1440-1446, 2006. [Abstract]

Naylor MF, Chen WR, Teague TK, Perry LA, Nordquist RE. In situ photoimmunotherapy: a tumour-directed treatment for melanoma. Br J Dermatol 155:1287-1292, 2006. [Abstract]

O’Hanlon TP, Rider LG, Mamyrova G, Targoff IN, Arnett FC, Reveille JD, Carrington M, Gao X, Oddis CV, Morel PA, Malley JD, Malley K, Shamim EA, Chanock SJ, Foster CB, Bunch T, Reed AM, Love LA, Miller FW. HLA polymorphisms in African Americans with idiopathic inflammatory myopathy: Allelic profiles distinguish patients with different clinical phenotypes and myositis autoantibodies. Arthritis Rheum 54:3670-3681, 2006. [Abstract]

O’Hanlon TP, Carrick DM, Targoff IN, Arnett FC, Reveille JD, Carrington M, Gao X, Oddis CV, Morel PA, Malley JD, Malley K, Shamim EA, Rider LG, Chanock SJ, Foster CB, Bunch T, Blackshear PJ, Plotz PH, Love LA, Miller FW. Immunogenetic risk and protective factors for the idiopathic inflammatory myopathies: distinct HLA-A, -B, -Cw, -DRB1, and -DQA1 allelic profiles distinguish European American patients with different myositis autoantibodies. Medicine (Baltimore) 85:111-127, 2006.[Abstract]

Pan ZJ, Davis K, Maier S, Bachmann MP, Kim-Howard XR, Keech C, Gordon TP, McCluskey J, Farris AD. Neo-epitopes are required for immunogenicity of the La/SS-B nuclear antigen in the context of late apoptotic cells. Clin Exp Immunol 143:237-248, 2006. [Abstract]

Poole BD, Scofield RH, Harley JB, James JA. Epstein-Barr virus and molecular mimicry in systemic lupus erythematosus. Autoimmunity 39:63-70, 2006. [Abstract]

Radhakrishna U, Ratnamala U, Gaines M, Beiraghi S, Hutchings D, Golla J, Husain SA, Gambhir PS, Sheth JJ, Sheth FJ, Chetan GK, Naveed M, Solanki JV, Patel UC, Master DC, Memon R, Antonarakis GS, Antonarakis SE, Nath SK. Genomewide scan for nonsyndromic cleft lip and palate in multigenerational Indian families reveals significant evidence of linkage at 13q33.1-34. Am J Hum Genet 79:580-585, 2006. [Abstract]

Ramos PS, Kelly JA, Gray-McGuire C, Bruner GR, Leiran AN, Meyer CM, Namjou B, Espe KJ, Ortmann WA, Reichlin M, Langefeld CD, James JA, Gaffney PM, Behrens TW, Harley JB, Moser KL. Familial aggregation and linkage analysis of autoantibody traits in pedigrees multiplex for systemic lupus erythematosus. Genes Immun 7:417-32, 2006. [Abstract]

Reichlin M. Autoantibodies to the ribosomal P proteins in systemic lupus erythematosus. Clin Exp Med 6:49-52, 2006. [Abstract]

Saban MR, Hellmich HL, Turner M, Nguyen NB, Vadigepalli R, Dyer DW, Hurst RE, Centola M, Saban R. The inflammatory and normal transcriptome of mouse bladder detrusor and mucosa. BMC Physiol 6:1, 2006. [Abstract]

Smith DD, Kovats S, Lee TD, Cano L. Median filter algorithm for estimating the threshold of detection on custom protein arrays. Biotechniques 41:74-78, 2006. [Abstract]

*Szodoray P, Alex P, Frank MB, Turner M, Turner S, Knowlton N, Cadwell C, Dozmorov I, Tang Y, Wilson PC, Jonsson R, Centola M. A genome-scale assessment of peripheral blood B-cell molecular homeostasis in patients with rheumatoid arthritis. Rheumatology (Oxford) 45:1466-1476, 2006. [Abstract]

Targoff IN. Myositis specific autoantibodies. Curr Rheumatol Rep 8:196-203, 2006. [Abstract]

Targoff IN, Mamyrova G, Trieu EP, Perurena O, Koneru B, O’Hanlon TP, Miller FW, Rider LG. A novel autoantibody to a 155-kd protein is associated with dermatomyositis. Arthritis Rheum 54:3682-3689, 2006. [Abstract]

Wang H, Kurien BT, Lundgren D, Patel NC, Kaufman KM, Miller DL, Porter AC, D’Souza A, Nye L, Tumbush J, Hupertz V, Kerr DS, Kurono S, Matsumoto H, Scofield RH. A nonsense mutation of PEPD in four Amish children with prolidase deficiency. Am J Med Genet A 140:580-585, 2006. [Abstract]

Cardiovascular Biology Research Program

Balazs AB, Fabian AJ, Esmon CT, Mulligan, RC. Endothelial protein C receptor (CD201) explicitly identifies hematopoietic stem cells in murine bone marrow. Blood 107:2317-2321, 2006[Abstract]

Borghei A, Ouyang YB, Westmuckett AD, Marcello MR, Landel CP, Evans JP, Moore KL. Targeted disruption of tyrosylprotein sulfotransferase-2, an enzyme that catalyzes post-translational protein tyrosine O-sulfation, causes male infertility. J Biol Chem 281:9423-31, 2006. [Abstract]

Chada D, Mather T, Nollert MU. The Synergy site of fibronectin is required for strong interaction with the platelet integrin alphaIIbbeta3. Ann Biomed Eng 34:1542-1552, 2006. [Abstract]

EsmonCT. The endothelial protein C receptor. Curr. Opin. Hematol 13:382-385, 2006. [Abstract]

Esmon CT. Inflammation and the activated protein C anticoagulant pathway. Semin Thromb Hemost 32 Suppl 1:49-60, 2006. [Abstract]

Hoffhines AJ, Damoc E, Bridges KG, Leary JA, Moore KL. Detection and purification of tyrosine-sulfated proteins using a novel anti-sulfotyrosine monoclonal antibody. J Biol Chem 281:37877-87, 2006. [Abstract]

Long M, Chen J, Jiang N, Selvaraj P, McEver RP, Zhu C. Probabilistic modeling of rosette formation. Biophys J 91:352-363, 2006. [Abstract]

Lou J, Yago T, Klopocki AG, Mehta P, Chen W, Zarnitsyna VI, Bovin NV, Zhu C, McEver RP. Flow-enhanced adhesion regulated by a selectin interdomain hinge. J Cell Biol 174:1107-1117, 2006. [Abstract]

Malykhina AP, Qin C, Greenwood-van Meerveld B, Foreman RD, Lupu F, Akbarali HI. Hyperexcitability of convergent colon and bladder dorsal root ganglion neurons after colonic inflammation: mechanism for pelvic organ cross-talk. Neurogastroenterol Motil 18:936-948, 2006. [Abstract]

Nam HJ, Gurda-Whitaker B, Gan WY, Ilaria S, McKenna R, Mehta P, Alvarez RA, Agbandje-McKenna M. Identification of the sialic acid structures recognized by minute virus of mice and the role of binding affinity in virulence adaptation. J Biol Chem 281:25670-25677, 2006. [Abstract]

Orlova VV, Economopoulou M, Lupu F, Santoso S, Chavakis T. Junctional adhesion molecule-C regulates vascular endothelial permeability by modulating VE-cadherin-mediated cell-cell contacts. J Exp Med 203:2703-14, 2006. [Abstract]

Qu D, Wang Y, Song Y, Esmon NL, Esmon CT. The Ser219–>Gly dimorphism of the endothelial protein C receptor contributes to the higher soluble protein levels observed in individuals with the A3 haplotype. J Thromb Haemost 4:229-235, 2006. [Abstract]

Rabeh WM, Mather T, Cook PF. A Three-dimensional homology model of the O-acetylserine Sulfhydrylase-B from Salmonella typhimurium. Protein Pept Lett 13:7-13, 2006. [Abstract]

Reneer DV, Kearns SA, Yago T, Sims J, Cummings RD, McEver RP, Carlyon JA. Characterization of a sialic acid- and P-selectin glycoprotein ligand-1-independent adhesin activity in the granulocytotropic bacterium Anaplasma phagocytophilum. Cell Microbiol 8:1972-84, 2006. [Abstract]

Rossignol P, Luttun A, Martin-Ventura JL, Lupu F, Carmeliet P, Collen D, Angles-Cano E, Lijnen HR. Plasminogen activation: a mediator of vascular smooth muscle cell apoptosis in atherosclerotic plaques. J Thromb Haemost 4:664-670, 2006. [Abstract]

Taylor FB, Jr., Hack E, Lupu F. Observations on complement activity in the two-stage inflammatory/hemostatic response in the baboon and human models of E. coli sepsis and endotoxemia. Adv Exp Med Biol 586:203-216, 2006. [Abstract]

Xia L, McEver RP. Targeted disruption of the gene encoding core 1 beta1-3-galactosyltransferase (T-synthase) causes embryonic lethality and defective angiogenesis in mice. Methods Enzymol 416:314-331, 2006. [Abstract]

Clinical Pharmacology Research Program

Merrill JT. Antiphospholipid syndrome: what’s new in understanding antiphospholipid antibody-related stroke? Curr Rheumatol Rep 8:159-161, 2006. [Abstract]

Merrill JT. Do antiphospholipid antibodies develop for a purpose? Curr Rheumatol Rep 8:109-113, 2006. [Abstract]

Merrill JT, Asherson RA. Catastrophic antiphospholipid syndrome. Nat.Clin.Pract.Rheumatol. 2:81-89. 2006. [Abstract]

Olech E, Merrill JT. The prevalence and clinical significance of antiphospholipid antibodies in rheumatoid arthritis. Curr Rheumatol Rep 8:100-108, 2006. [Abstract]

Crystallography Research Program

Ramsland PA, Terzyan SS, Cloud G, Bourne CR, Farrugia W, Tribbick G, Geysen HM, Moomaw CR, Slaughter CA, Edmundson AB. Crystal structure of a glycosylated Fab from an IgM cryoglobulin with properties of a natural proteolytic antibody. Biochem J 395:473-481, 2006. [Abstract]

Su D, Lou ZY, Sun F, Zhai YJ, Yang HT, Zhang RG, Joachimiak A, Zhang XJC, Bartlam M, Rao ZH. Dodecamer structure of severe acute respiratory syndrome coronavirus nonstructural protein nsp10. J Virol 80:7902-7908, 2006.[Abstract]

Wang L, Sun N, Terzyan S, Zhang X, Benson DR. A histidine/tryptophan pi-stacking interaction stabilizes the heme-independent folding core of microsomal apocytochrome b₅ relative to that of mitochondrial apocytochrome b₅. Biochemistry 45:13750-13759, 2006. [Abstract]

Xu X, Zhai Y, Sun F, Lou Z, Su D, Xu Y, Zhang R, Joachimiak A, Zhang XC, Bartlam M, Rao Z. New antiviral target revealed by the hexameric structure of mouse hepatitis virus nonstructural protein nsp15. J Virol 80:7909-7917, 2006. [Abstract]

Free Radical Biology and Aging Research Program

Asada K, Asada R, Yoshiji H, Fukui H, Floyd RA, Kotake Y. DNA cytosine methylation profile in various cancer-related genes is altered in cultured rat hepatocyte cell lines as compared with primary hepatocytes. Oncol Rep 15:1241-1248, 2006. [Abstract]

Broyles RH, Roth AC, Todd M, Belegu V. Nuclear reprogramming by cell fusion. Methods Mol Biol 325:47-57, 2006. [Abstract]

Bulteau AL, Szweda LI, Friguet B. Mitochondrial protein oxidation and degradation in response to oxidative stress and aging. Exp Gerontol 41: 653-7, 2006. [Abstract]

Farout L, Mary J, Vinh J, Szweda LI, Friguet B. Inactivation of the proteasome by 4-hydroxy-2-nonenal is site specific and dependant on 20S proteasome subtypes. Arch Biochem Biophys 453: 135-42, 2006. [Abstract]

Floyd RA. Nitrones as therapeutics in age-related diseases. Aging Cell 5:51-57, 2006. [Abstract]

Haynes RL, Folkerth RD, Szweda LI, Volpe JJ, Kinney HC. Lipid peroxidation during human cerebral myelination. J Neuropathol Exp Neurol 65:894-904, 2006. [Abstract]

Hensley K, Abdel-Moaty H, Hunter J, Mhatre M, Mou S, Nguyen K, Potapova T, Pye QN, Qi M, Rice H, Stewart C, Stroukoff K, West M. Primary glia expressing the G93A-SOD1 mutation present a neuroinflammatory phenotype and provide a cellular system for studies of glial inflammation. J Neuroinflammation 3:2, 2006. [Abstract]

Hensley K, Mhatre M, Mou S, Pye QN, Stewart C, West M, Williamson KS. On the relation of oxidative stress to neuroinflammation: lessons learned from the G93A-SOD1 mouse model of a myotrophic lateral sclerosis. Antioxid Redox Signal 8:2075-2087, 2006. [Abstract]

Humphries KM, Szweda PA, Szweda LI. Aging: A shift from redox regulation to oxidative damage. Free Radic Res 40:1239-1243, 2006. [Abstract]

Kamibayashi M, Oowada S, Kameda H, Okada T, Inanami O, Ohta S, Ozawa T, Makino K, Kotake Y. Synthesis and characterization of a practically better DEPMPO-type spin trap, 5-(2,2-dimethyl-1,3-propoxy cyclophosphoryl)-5-methyl-1-pyrroline N-oxide (CYPMPO). Free Radic Res 40:1166-1172, 2006. [Abstract]

Kiaei M, Petri S, Kipiani K, Gardian G, Choi DK, Chen J, Calingasan NY, Schafer P, Muller GW, Stewart C, Hensley K, Beal MF. Thalidomide and lenalidomide extend survival in a transgenic mouse model of amyotrophic lateral sclerosis. J Neurosci 26:2467-2473, 2006. [Abstract]

Kopke RD, Wassel RA, Mondalek F, Grady B, Chen K, Liu J, Gibson D, Dormer KJ. Magnetic nanoparticles: inner ear targeted molecule delivery and middle ear implant. Audiol Neurootol 11:123-133, 2006. [Abstract]

Kurien BT, Hensley K, Bachmann M, Scofield RH. Oxidatively modified autoantigens in autoimmune diseases. Free Radic Biol Med 41:549-556, 2006. [Abstract]

Lashin OM, Szweda PA, Szweda LI, Romani AM. Decreased complex II respiration and HNE-modified SDH subunit in diabetic heart. Free Radic Biol Med 40:886-896, 2006. [Abstract]

Lundberg KC, Szweda LI. Preconditioning prevents loss in mitochondrial function and release of cytochrome c during prolonged cardiac ischemia/reperfusion. Arch Biochem Biophys 453:130-34, 2006. [Abstract]

Matsumoto T, Kaneko T, Wada H, Kobayashi T, Abe Y, Nobori T, Shiku H, Stearns-Kurosawa DJ, Kurosawa S. Proteinase 3 expression on neutrophil membranes from patients with infectious disease. Shock 26:128-133, 2006. [Abstract]

Mhatre M. The role of the 5-lipoxygenase pathway in Alzheimer’s disease.  Drugs Future 31:83-89, 2006.

Mhatre M, Hensley K, Nguyen A, Grammas P. Chronic thrombin exposure results in an increase in apolipoprotein-E levels. J Neurosci Res 84:444-449, 2006. [Abstract]

Picot CR, Perichon M, Lundberg KC, Friguet B, Szweda LI, Petropoulos I. Alterations in mitochondrial and cytosolic methionine sulfoxide reductase activity during cardiac ischemia and reperfusion. Exp Gerontol 41: 663-667, 2006. [Abstract]

Siddiqui A, Ancha H, Tedesco D, Lightfoot S, Stewart CA, Harty RF. Antioxidant therapy with N-acetylcysteine plus mesalamine accelerates mucosal healing in a rodent model of colitis. Dig Dis Sci 51:698-705, 2006. [Abstract]

Stearns-Kurosawa DJ, Lupu F, Taylor FB, Jr., Kinasewitz G, Kurosawa S. Sepsis and pathophysiology of anthrax in a nonhuman primate model. Am J Pathol 169:433-444, 2006. [Abstract]

Immunobiology and Cancer Research Program

Baba Y, Yokota T, Spits H, Garrett KP, Hayashi S, Kincade PW. Constitutively active beta-catenin promotes expansion of multipotent hematopoietic progenitors in culture. J Immunol 177:2294-2303, 2006. [Abstract]

Chakrabarty K, Wu W, Booth JL, Duggan ES, Coggeshall KM, Metcalf JP. Bacillus anthracis spores stimulate cytokine and chemokine innate immune responses in human alveolar macrophages through multiple mitogen-activated protein kinase pathways. Infect Immun 74:4430-4438, 2006. [Abstract]

Colgan SP, Eltzschig HK, Eckle T, Thompson LF. Physiological roles for ecto-5′-nucleotidase (CD73). Purinergic Signal 2:351-360, 2006. [Abstract]

Eltzschig HK, Faigle M, Knapp S, Karhausen J, Ibla J, Rosenberger P, Odegard KC, Laussen PC, Thompson LF, Colgan SP. Endothelial catabolism of extracellular adenosine during hypoxia: the role of surface adenosine deaminase and CD26. Blood 108:1602-1610, 2006. [Abstract]

Hashikawa T, Takedachi M, Terakura M, Yamada S, Thompson LF, Shimabukuro Y, Murakami S. Activation of adenosine receptor on gingival fibroblasts. J Dent Res 85:739-744, 2006. [Abstract]

Igarashi H, Baba Y, Nagai Y, Jimi E, Ghosh S, Kincade PW. NF-{kappa}B is dispensable for normal lymphocyte development in bone marrow but required for protection of progenitors from TNF{alpha}. Int Immunol 18: 653-659, 2006. [Abstract]

Joachims ML, Chain JL, Hooker SW, Knott-Craig CJ, Thompson LF. Human {alpha}beta and {gamma}{delta} thymocyte development: TCR gene rearrangements, intracellular TCR beta expression, and {gamma}{delta} developmental potential–differences between men and mice. J Immunol 176:1543-1552, 2006. [Abstract]

Kincade PW. MAb JY/93 anti-murine CD72. Hybridoma (Larchmt.) 25(3), 178. 2006.

Kincade PW. Supplying the demand for granulocytes. Nat Immunol 7:701-702, 2006. [Abstract]

Nagai Y, Garrett KP, Ohta S, Bahrun U, Kouro T, Akira S, Takatsu K, Kincade PW. Toll-like receptors on hematopoietic progenitor cells stimulate innate immune system replenishment. Immunity 24:801-812, 2006. [Abstract]

Pelayo R, Miyazaki K, Huang J, Garrett KP, Osmond DG, Kincade PW. Cell cycle quiescence of early lymphoid progenitors in adult bone marrow. Stem Cells 24:2703-13, 2006.  [Abstract]

Pelayo R, Welner RS, Nagai Y, Kincade PW. Life before the pre-B cell receptor checkpoint: Specification and commitment of primitive lymphoid progenitors in adult bone marrow. Semin. Immunol. 18:2-11, 2006.  [Abstract]

Perry SS, Welner RS, Kouro T, Kincade PW, Sun XH. Primitive lymphoid progenitors in bone marrow with T lineage reconstituting potential. J Immunol 177:2880-2887, 2006.  [Abstract]

Rajaiya J, Nixon JC, Ayers N, Desgranges ZP, Roy AL, Webb CF. Induction of immunoglobulin heavy-chain transcription through the transcription factor Bright requires TFII-I. Mol Cell Biol 26:4758-4768, 2006. [Abstract]

Van De Wiele CJ, Joachims ML, Fesler AM, Vaughn JG, Blackburn MR, McGee ST, Thompson LF. Further differentiation of murine double-positive thymocytes is inhibited in adenosine deaminase-deficient murine fetal thymic organ culture. J Immunol 176:5925-5933, 2006. [Abstract]

Volmer JB, Thompson LF, Blackburn MR. Ecto-5′-nucleotidase (CD73)-mediated adenosine production is tissue protective in a model of bleomycin-induced lung injury. J Immunol 176:4449-4458, 2006. [Abstract]

Webb CF, Kincade PW. The divergence of lymphocyte development pathways. J Immunol 176:6369, 2006. [Abstract]

Wu W, Booth JL, Coggeshall KM, Metcalf JP. Calcium-dependent viral internalization is required for adenovirus type 7 induction of IL-8 protein. Virology 355:18-29, 2006. [Abstract]

Yamashita Y, Phee H, Tudor KS, Rossi MI, Parnes JR, Coggeshall KM, Kincade PW. A unique CD72 epitope suggests a potential interaction with FcgammaRII/CD32 on B lineage lymphocytes. Hybridoma (Larchmt ) 25:107-114, 2006. [Abstract]

Yang Y, Liou HC, Sun XH. Id1 potentiates NF-kappa B activation upon T cell receptor signaling. J Biol Chem 281:34989-96, 2006. [Abstract]

Yokota T, Huang J, Tavian M, Nagai Y, Hirose J, Zuniga-Pflucker JC, Peault B, Kincade PW. Tracing the first waves of lymphopoiesis in mice. Development 133:2041-2051, 2006. [Abstract]

Yokota T, Kawakami Y, Nagai Y, Ma JX, Tsai JY, Kincade PW, Sato S. Bone marrow lacks a transplantable progenitor for smooth muscle type {alpha}-actin expressing cells. Stem Cells 24: 13-22, 2006.[Abstract]

Lipid and Lipoprotein Laboratory

Alaupovic P, Attman PO, Knight-Gibson C, Mulec H, Weiss L, Samuelsson O. Effect of fluvastatin on apolipoprotein-defined lipoprotein subclasses in patients with chronic renal insufficiency. Kidney Int 69: 1865-71, 2006. [Abstract]

Blackett PR, Wang W, Quintana E, Alaupovic P, Lee ET. Apolipoproteins in Cherokee children and adolescents. Cesk Pediatr 61: 477-483, 2006.

Hodis HN, Mack WJ, Zheng L, Li Y, Torres M, Sevilla D, Stewart Y, Hollen B, Garcia K, Alaupovic P, Buchanan TA. Effect of peroxisome proliferator-activated receptor {gamma} agonist treatment on subclinical atherosclerosis in patients with insulin-requiring type 2 diabetes. Diabetes Care 29:1545-1553, 2006. [Abstract]

Molecular, Cell and Developmental Biology Research Program

Barstead RJ, Moerman DG. C. elegans deletion mutant screening. Methods Mol Biol 351:51-58, 2006. [Abstract]

Charlie NK, Schade MA, Thomure AM, Miller KG. Presynaptic UNC-31 (CAPS) is required to activate the G alpha(s) pathway of the Caenorhabditis elegans synaptic signaling network. Genetics 172:943-961, 2006. [Abstract]

Charlie NK, Thomure AM, Schade MA, Miller KG. The Dunce cAMP phosphodiesterase PDE-4 regulates G{alpha}s – dependent and G{alpha}s- independent cAMP pools in the Caenorhabditis elegans synaptic signaling network. Genetics 173: 111-130, 2006. [Abstract]

Clarke M, Maddera L. Phagocyte meets prey: Uptake, internalization, and killing of bacteria by Dictyostelium amoebae. Eur J Cell Biol 85:1001-1010, 2006. [Abstract]

Clarke M, Muller-Taubenberger A, Anderson KI, Engel U, Gerisch G. Mechanically induced actin-mediated rocketing of phagosomes. Mol Biol Cell 17:4866-4875, 2006. [Abstract]

Costa JL, Hochgeschwender U, Brennan M. The role of melanocyte-stimulating hormone in insulin resistance and type 2 diabetes mellitus. Treat Endocrinol 5:7-13, 2006. [Abstract]

Daum JR, Gorbsky GJ. Lysed cell models and isolated chromosomes for the study of kinetochore/centromere biochemistry in vitro. Methods 38:52-59, 2006. [Abstract]

Eyster CA, Duggins QS, Gorbsky GJ, Olson AL. Microtubule network is required for insulin signaling through activation of Akt/protein kinase B: Evidence that insulin stimulates vesicle docking/fusion but not intracellular mobility. J Biol Chem 281: 39719-27, 2006. [Abstract]

Karpac J, Ostwald D, Li GY, Bui S, Hunnewell P, Brennan MB, Hochgeschwender U. Proopiomelanocortin heterozygous and homozygous null mutant mice develop pituitary adenomas. Cell Mol Biol (Noisy -le-grand) 52:47-52, 2006. [Abstract]

Kateneva AV, Dresser ME. Sister chromatid cohesion remodeling and meiotic recombination. Cell Cycle 5:467-471, 2006. [Abstract]

Luque RM, Gahete MD, Hochgeschwender U, Kineman RD. Evidence that endogenous SST inhibits ACTH and ghrelin expression by independent pathways. Am J Physiol Endocrinol Metab 291:E395-E403, 2006.  [Abstract]

Mullen GP, Mathews EA, Saxena P, Fields SD, McManus JR, Moulder G, Barstead RJ, Quick MW, Rand JB. The Caenorhabditis elegans snf-11gene encodes a sodium-dependent GABA transporter required for clearance of synaptic GABA. Mol Biol Cell 17:3021-30, 2006. [Abstract]

Ostwald D, Karpac J, Hochgeschwender U. Effects on hippocampus of lifelong absence of glucocorticoids in the pro-opiomelanocortin null mutant mouse reveal complex relationship between glucocorticoids and hippocampal structure and function. J Mol Neurosci 28:291-302, 2006. [Abstract]

Potapova TA, Daum JR, Pittman BD, Hudson JR, Jones TN, Satinover DL, Stukenberg PT, Gorbsky GJ. The reversibility of mitotic exit in vertebrate cells. Nature 440:954-958, 2006. [Abstract]

Rankin S. A wapl a day keeps the sisters apart: wapl and cohesin dynamics. Dev Cell 11:754-755, 2006. [Abstract]

Sandoval GM, Duerr JS, Hodgkin J, Rand JB, Ruvkun G. A genetic interaction between the vesicular acetylcholine transporter VAChT/UNC-17 and synaptobrevin/SNB-1 in C. elegans. Nat Neurosci 9:599-601, 2006. [Abstract]

Weimer RM, Gracheva EO, Meyrignac O, Miller KG, Richmond JE, Bessereau JL. UNC-13 and UNC-10/rim localize synaptic vesicles to specific membrane domains. J Neurosci 26:8040-8047, 2006. [Abstract]

Yakovleva T, Bazov I, Cebers G, Marinova Z, Hara Y, Ahmed A, Vlaskovska M, Johansson B, Hochgeschwender U, Singh IN, Bruce-Keller AJ, Hurd YL, Kaneko T, Terenius L, Ekstrom TJ, Hauser KF, Pickel VM, Bakalkin G. Prodynorphin storage and processing in axon terminals and dendrites. FASEB J 20:2124-2126, 2006. [Abstract]

Yamada HY, Gorbsky GJ. Cell-based expression cloning for identification of polypeptides that hypersensitize mammalian cells to mitotic arrest. Biol Proced Online 8:36-43, 2006. [Abstract]

Yamada HY, Gorbsky GJ. Inhibition of TRIP1/S8/hSug1, a component of the human 19S proteasome, enhances mitotic apoptosis induced by spindle poisons. Mol Cancer Ther 5:29-38, 2006. [Abstract]

Yamada HY, Gorbsky GJ. Spindle checkpoint function and cellular sensitivity to antimitotic drugs. Mol Cancer Ther 5:2963-2969, 2006. [Abstract]

Molecular Immunogenetics Research Program

Kolar GR, Mehta D, Wilson PC, Capra JD. Diversity of the Ig repertoire is maintained with age in spite of reduced germinal centre cells in human tonsil lymphoid tissue. Scand J Immunol 64:314-324, 2006. [Abstract]

Rahman NS, Godderz LJ, Stray SJ, Capra JD, Rodgers KK. DNA cleavage of a cryptic recombination signal sequence by RAG1 and RAG2: Implications for partial VH gene replacement. J Biol Chem 281: 12370-12380, 2006. [Abstract]

*Szodoray P, Alex P, Frank MB, Turner M, Turner S, Knowlton N, Cadwell C, Dozmorov I, Tang Y, Wilson PC, Jonsson R, Centola M. A genome-scale assessment of peripheral blood B-cell molecular homeostasis in patients with rheumatoid arthritis. Rheumatology (Oxford) 45:1466-1476, 2006. [Abstract]

Protein Studies Research Program

Ghosh AK, Kumaragurubaran N, Hong L, Lei H, Hussain KA, Liu CF, Devasamudram T, Weerasena V, Turner R, Koelsch G, Bilcer G, Tang J. Design, synthesis and X-ray structure of protein-ligand complexes: important insight into selectivity of memapsin 2 (beta-secretase) inhibitors. J Am Chem Soc 128:5310-5311, 2006. [Abstract]

* Indicates publications by more than one department.

01/13/10