2004 Scientific Publications

Arthritis Research Program

Dozmorov,I., N.Knowlton, Y.Tang, and M.Centola. 2004. Statistical monitoring of weak spots for improvement of normalization and ratio estimates in microarrays. BMC.Bioinformatics 5:53. [Abstract]

Dozmorov,I., N.Knowlton, Y.Tang, A.Shields, P.Pathipvanich, J.N.Jarvis, and M.Centola. 2004. Hypervariable genes–experimental error or hidden dynamics. Nucleic Acids Res 32:e147. [Abstract]

Gomez,M., R.M.Clark, S.K.Nath, S.Bhatti, R.Sharma, E.Alonso, A.Rasmussen, and S.I.Bidichandani. 2004. Genetic admixture of European FRDA genes is the cause of Friedreich ataxia in the Mexican population. Genomics 84:779-784. [Abstract]

Hitchon,C.A., P.Alex, L.B.Erdile, M.B.Frank, I.Dozmorov, Y.Tang, K.Wong, M.Centola, and H.S.El Gabalawy. 2004. A distinct multicytokine profile is associated with anti-cyclical citrullinated Peptide antibodies in patients with early untreated inflammatory arthritis. J Rheumatol. 31:2336-2346. [Abstract]

James JA, Aggarwal AK, Linden RM, Escalante CR. Structure of adeno-associated virus type 2 Rep40-ADP complex: insight into nucleotide recognition and catalysis by superfamily 3 helicases. Proc Natl Acad Sci U S A 101:12455-12460, 2004. [Abstract]

Jarvis,J.N., I.Dozmorov, K.Jiang, Y.Chen, M.B.Frank, C.Cadwell, S.Turner, and M.Centola. 2004. Gene expression arrays reveal a rapid return to normal homeostasis in immunologically-challenged trophoblast-like JAR cells. J.Reprod.Immunol. 61:99-113. [Abstract]

Jarvis,J.N., I.Dozmorov, K.Jiang, M.B.Frank, P.Szodoray, P.Alex, and M.Centola. 2004. Novel approaches to gene expression analysis of active polyarticular juvenile rheumatoid arthritis. Arthritis Res.Ther. 6:R15-R32. [Abstract]

Jorgensen,E.D., I.Dozmorov, M.B.Frank, M.Centola, and A.P.Albino. 2004. Global Gene Expression Analysis of Human Bronchial Epithelial Cells Treated with Tobacco Condensates. Cell Cycle 3:1154-1168. [Abstract]

Knowlton,N., I.M.Dozmorov, and M.Centola. 2004. Microarray data analysis toolbox (MDAT): for normalization, adjustment and analysis of gene expression data. Bioinformatics. 20: 3687-3690. [Abstract]

* Kolar,G.R., T.Yokota, M.I.Rossi, S.K.Nath, and J.D.Capra. 2004. Human fetal, cord blood, and adult lymphocyte progenitors have similar potential for generating B cells with a diverse immunoglobulin repertoire. Blood. 104:2981-7. [Abstract]

Kurien,B.T., N.E.Everds, and R.H.Scofield. 2004. Experimental animal urine collection: a review. Lab Anim 38:333-361. [Abstract]

Kurien,B.T., N.C.Patel, A.C.Porter, S.Kurono, H.Matsumoto, H.Wang, and R.H. Scofield. 2004. Determination of prolidase activity using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Anal.Biochem. 331:224-229. [Abstract]

* Kurien,B.T., B.W.Pillow, Y.Dorri, K.Hensley, M.Bachman, and R.H.Scofield. 2004. SOD1 interacts directly with hemoglobin in vitro. Thromb.Haemost. 92:218-220. [Abstract]

Kurien,B.T., A.C.Porter, N.C.Patel, S.Kurono, H.Matsumoto, and R.H.Scofield. 2004. Mechanized syringe homogenization of human and animal tissues. Assay.Drug Dev.Technol. 2:308-312. [Abstract]

McClain,M.T., M.R.Arbuckle, L.D.Heinlen, G.J.Dennis, J.Roebuck, M.V.Rubertone, J.B.Harley, and J.A.James. 2004. The prevalence, onset, and clinical significance of antiphospholipid antibodies prior to diagnosis of systemic lupus erythematosus. Arthritis Rheum. 50:1226-1232. [Abstract]

McClain,M.T., C.S.Lutz, K.M.Kaufman, O.Z.Faig, T.F.Gross, and J.A.James. 2004. Structural availability influences the capacity of autoantigenic epitopes to induce a widespread lupus-like autoimmune response. Proc.Natl.Acad.Sci.U.S.A. 101:3551-3556. [Abstract]

Nath,S.K., J.A.Kelly, J.B.Harley, and R.H.Scofield. 2004. Mapping the systematic lupus erythematosus susceptibility genes. Methods Mol Med. 102:11-30. [Abstract]

Nath,S.K., J.Kilpatrick, and J.B.Harley. 2004. Genetics of human systemic lupus erythematosus: the emerging picture. Curr Opin.Immunol. 16:794-800. [Abstract]

Nath,S.K., B.Namjou, C.P.Garriott, S.Frank, P.A.Joslin, J.Kilpatrick, J.A.Kelly, and J.B.Harley. 2004. Linkage analysis of SLE susceptibility: confirmation of SLER1 at 5p15.3. Genes Immun. 5:209-214. [Abstract]

Nath,S.K., B.Namjou, D.Hutchings, C.P.Garriott, C.Pongratz, J.Guthridge, and J.A.James. 2004. Systemic lupus erythematosus (SLE) and chromosome 16: confirmation of linkage to 16q12-13 and evidence for genetic heterogeneity. Eur.J.Hum.Genet. 12:668-72. [Abstract]

Nath,S.K., B.Namjou, J.Kilpatrick, C.P.Garriott, G.R.Bruner, R.H.Scofield, and J.B.Harley. 2004. A candidate region on 11p13 for systemic lupus erythematosus: A linkage identified in African-American families. J Invest Dermatol Symp Proc 9:64-67. [Abstract]

Nath,S.K., A.I.Quintero-Del-Rio, J.Kilpatrick, L.Feo, M.Ballesteros, and J.B.Harley. 2004. Linkage at 12q24 with Systemic Lupus Erythematosus (SLE) Is Established and Confirmed in Hispanic and European American Families. Am.J.Hum.Genet. 74:73-82. [Abstract]

Nunlist,E.H., I.Dozmorov, Y.Tang, R.Cowan, M.Centola, and H.K.Lin. 2004. Partitioning of 5alpha-dihydrotestosterone and 5alpha-androstane-3alpha, 17beta-diol activated pathways for stimulating human prostate cancer LNCaP cell proliferation. J Steroid Biochem.Mol Biol 91:157-170. [Abstract]

O’Hanlon,T., B.Koneru, E.Bayat, L.Love, I.Targoff, J.Malley, K.Malley, and F.Miller. 2004. Immunogenetic differences between Caucasian women with and those without silicone implants in whom myositis develops. Arthritis Rheum 50:3646-3650. [Abstract]

Quintero-del-Rio,A.I., J.A.Kelly, C.P.Garriott, D.C.Hutchings, S.G.Frank, C.E.Aston, and J.B.Harley. 2004. SLEN2 (2q34-35) and SLEN1 (10q22.3) replication in systemic lupus erythematosus stratified by nephritis. Am.J Hum.Genet. 75:346-348.

Sawalha,A.H. and J.B.Harley. 2004. Antinuclear autoantibodies in systemic lupus erythematosus. Curr Opin.Rheumatol. 16:534-540. [Abstract]

Sawalha,A.H., W.R.Schmid, S.R.Binder, D.K.Bacino, and J.B.Harley. 2004. Association between systemic lupus erythematosus and Helicobacter pylori seronegativity. J Rheumatol. 31:1546-1550. [Abstract]

Scofield,R.H. 2004. Autoantibodies as predictors of disease. Lancet 363:1544-1546. [Abstract]

Scofield,R.H. 2004. Genetic knock out of 60kD Ro (or SSA), a common lupus autoantigen, induces lupus. Trends Immunol. 25:1-3. [Abstract]

Scofield,R.H., B.T.Kurien, J.K.Gross, N.B.Reed, A.K.Taylor, N.Dominguez, P.Mehta, J.M.Guthridge, and M.Bachmann. 2004. Interaction of calcium and Ro60: increase of antigenicity. Mol Immunol. 41:809-816. [Abstract]

Shenoi,J., B.T.Kurien, S.Kurono, R.Mascarenhas, H.Matsumoto, and R.H.Scofield. 2004. Cost-benefit analysis of a method using diatomaceous earth to purify Tamm-Horsfall protein. Biotechniques 36:64-66. [Abstract]

Szodoray,P., P.Alex, J.G.Brun, M.Centola, and R.Jonsson. 2004. Circulating cytokines in primary Sjogren’s syndrome determined by a multiplex cytokine array system. Scand.J Immunol. 59:592-599. [Abstract]

Szodoray,P., P.Alex, V.Dandapani, B.Nakken, J.Pesina, X.Kim, G.L.Wallis, P.C.Wilson, R.Jonsson, and M.Centola. 2004. Apoptotic effect of rituximab on peripheral blood B cells in rheumatoid arthritis. Scand.J.Immunol. 60:209-218. [Abstract]

* Szodoray P., S. Jellestad, P. Alex, T. Zhou, P.C. Wilson, M.Centola,J.B. Brun, R.Jonsson. 2004. Programmed cell death of peripheral blood B cells determined by laser scanning cytometry in Sjogren’s syndrome with a special emphasis on BAFF. J Clin Immunol 24:600-611, 2004. [Abstract]

Zimmerman,R.A., I.Dozmorov, E.H.Nunlist, Y.Tang, X.Li, R.Cowan, M.Centola, M.B.Frank, D.J.Culkin, and H.K.Lin. 2004. 5alpha-Androstane-3alpha,17beta-diol activates pathway that resembles the epidermal growth factor responsive pathways in stimulating human prostate cancer LNCaP cell proliferation. Prostate Cancer Prostatic.Dis. 7:364-374. [Abstract]

Cardiovascular Biology Research Program

Annamalai,R., B.Jin, Z.H.Cao, S.M.C.Newton, and P.E.Klebba. 2004. Recognition of ferric catecholates by FepA. J Bacteriol 186:3578-3589. [Abstract]

Dhainaut,J.F., W.Aird, and C.Esmon. 2004. Introduction to the Fifth Margaux Conference on Critical Illness: Protein C pathways: Bedside to bench. Crit Care Med. 32:S193. [Abstract]

Esmon,C.T. 2004. Crosstalk between inflammation and thrombosis. Maturitas 47:305-314. [Abstract]

Esmon,C.T. 2004. The impact of the inflammatory response on coagulation. Thromb Res 114:321-327. [Abstract]

Esmon,C.T. 2004. Interactions between the innate immune and blood coagulation systems. Trends Immunol. 25:536-542. [Abstract]

Esmon,C.T. 2004. Structure and functions of the endothelial cell protein C receptor. Crit Care Med. 32:S298-S301. [Abstract]

Esmon,C.T. 2004. Why do animal models (sometimes) fail to mimic human sepsis? Crit Care Med. 32:S219-S222. [Abstract]

Esmon,C.T. and W.G.Owen. 2004. The discovery of thrombomodulin. J.Thromb.Haemost. 2:209-213. {Abstract]

* Huang,X.P., W.P.Chang, G.Koelsch, R.Turner, III, F.Lupu, and J.Tang. 2004. Internalization of exogenously added memapsin 2 (beta -secretase) ectodomain by cells Is mediated by amyloid precursor protein. J Biol Chem. 279:37886-37894 [Abstract]

Huang,J., J.Chen, S.E.Chesla, T.Yago, P.Mehta, R.P.Mcever, C.Zhu, and M.Long. 2004. Quantifying the effects of molecular orientation and length on two-dimensional receptor-ligand binding kinetics. J Biol Chem 279:44915-44923. [Abstract]

Jin,X., A.P.Malykhina, F.Lupu, and H.I.Akbarali. 2004. Altered gene expression and increased bursting activity of colonic smooth muscle ATP-sensitive K+ channels in experimental colitis. Am.J.Physiol Gastrointest.Liver Physiol. 287:G274-G285. [Abstract]

Kappelmayer,J., B.Nagy, K.Miszti-Blasius, Z.Hevessy, and H.Setiadi. 2004. The emerging value of P-selectin as a disease marker. Clin Chem Lab Med 42:475-486. [Abstract]

Kinasewitz,G.T., S.B.Yan, B.Basson, P.Comp, J.A.Russell, A.Cariou, S.L.Um, B.Utterback, P.F.Laterre, and J.F.Dhainaut. 2004. Universal changes in biomarkers of coagulation and inflammation occur in patients with severe sepsis, regardless of causative micro-organism [ISRCTN74215569]. Crit Care 8:R82-R90. [Abstract]

Li,W., D.J.Johnson, C.T.Esmon, and J.A.Huntington. 2004. Structure of the antithrombin-thrombin-heparin ternary complex reveals the antithrombotic mechanism of heparin. Nat.Struct Mol Biol 11:857-862. [Abstract]

Liaw,P.C., C.T.Esmon, K.Kahnamoui, S.Schmidt, S.Kahnamoui, G.Ferrell, S.Beaudin, J.A.Julian, J.I.Weitz, M.Crowther, M.Loeb, and D.J.Cook. 2004. Patients with severe sepsis vary markedly in their ability to generate activate protein C. Blood. 104:3958-3964. [Abstract]

Marcus, W.D., McEver, R.P., and C. Zhu. Forces required to initiate membrane tether extrusion from cell surface depend on cell type but not on the surface molecule. Mech Chem Biosyst 1:245-251, 2004. [Abstract]

Mehta,A., R.Brewington, M.Chatterji, M.Zoubine, G.T.Kinasewitz, G.T.Peer, A.C.K.Chang, F.B.Taylor, and A.Shnyra. 2004. Infection-induced modulation of M1 and M2 phenotypes in circulating monocytes: Role in immune monitoring and early prognosis of sepsis. Shock 22:423-430. [Abstract]

Ramachandran,V., M.Williams, T.Yago, D.W.Schmidtke, and R.P.Mcever. 2004. Dynamic alterations of membrane tethers stabilize leukocyte rolling on P-selectin. Proc Natl Acad Sci U S A 101:13519-13524. [Abstract]

Rijneveld,A.W., S.Weijer, S.Florquin, C.T.Esmon, J.C.Meijers, P.Speelman, P.H.Reitsma, H.ten Cate, and P.T.Van Der. 2004. Thrombomodulin mutant mice with a strongly reduced capacity to generate Activated Protein C have an unaltered pulmonary immune response to respiratory pathogens and lipopolysaccharide. Blood.103:1702-9. [Abstract]

Sarangapani,K.K., T.Yago, A.G.Klopocki, M.B.Lawrence, C.B.Fieger, S.D.Rosen, R.P.McEver, and C.Zhu. 2004. Low force decelerates L-selectin dissociation from P-selectin glycoprotein ligand-1 and endoglycan. J Biol Chem 279:2291-2298. [Abstract]

Svensson,A.M., B.L.Waters, Z.G.Laszik, L.Simmons-Arnold, A.Goodwin, B.G.Beatty, and E.G.Bovill. 2004. The protein C system in placental massive perivillous fibrin deposition. Blood Coagul Fibrinolysis 15:491-495. [Abstract]

Taylor,F.B. and G.Kinasewitz. 2004. Activated protein C in sepsis. J.Thromb.Haemost. 2:708-717 [Abstract]

Xia,L., T.Ju, A.Westmuckett, G.An, L.Ivanciu, J.M.McDaniel, F.Lupu, R.D.Cummings, and R.P.McEver. 2004. Defective angiogenesis and fatal embryonic hemorrhage in mice lacking core 1-derived O-glycans. J.Cell Biol. 164:451-459. [Abstract]

Xia,L., J.M.McDaniel, T.Yago, A.Doeden, and R.P.McEver. 2004. Surface fucosylation of human cord blood cells augments binding to P-selectin and E-selectin and enhances engraftment in bone marrow. Blood. 104:3091-3096. [Abstract]

Yago,T., J.Wu, C.D.Wey, A.G.Klopocki, C.Zhu, and R.P.McEver. 2004. Catch bonds govern adhesion through L-selectin at threshold shear. J Cell Biol 166:913-923. [Abstract]

Zhuang,D., A.C.Ceacareanu, Y.Lin, B.Ceacareanu, M.Dixit, K.E.Chapman, C.M.Waters, G.N.Rao, and A.Hassid. 2004. Nitric oxide attenuates insulin- or IGF-I-stimulated aortic smooth muscle cell motility by decreasing H2O2 levels: essential role of cGMP. Am.J Physiol Heart Circ.Physiol 286:H2103-H2112. [Abstract]

Clinical Pharmacology Research Program

Horita,T. and J.T.Merrill. 2004. Genetics of antiphospholipid syndrome. Curr Rheumatol.Rep. 6:458-462. [Abstract]

Lopez,L.R., K.J.Dier, D.Lopez, J.T.Merrill, and C.A.Fink. 2004. Anti-beta 2-glycoprotein I and antiphosphatidylserine antibodies are predictors of arterial thrombosis in patients with antiphospholipid syndrome. Am.J.Clin.Pathol. 121:142-149. [Abstract]

Merrill,J.T. 2004. Antibodies and clinical features of the antiphospholipid syndrome as criteria for systemic lupus erythematosus. Lupus 13:869-876. [Abstract]

Merrill,J.T. 2004. Diagnosis of the antiphospholipid syndrome: how far to go? Curr Rheumatol.Rep. 6:469-472. [Abstract]

Merrill,J.T. 2004. LJP 1082: a toleragen for Hughes syndrome. Lupus 13:335-338. [Abstract]

Merrill,J.T., D.Erkan, and J.P.Buyon. 2004. Challenges in bringing the bench to bedside in drug development for sle. Nat.Rev.Drug Discov. 3:1036-1046. [Abstract]

Petri,M.A., P.J.Mease, J.T.Merrill, R.G.Lahita, M.J.Iannini, D.E.Yocum, E.M.Ginzler, R.S.Katz, O.S.Gluck, M.C.Genovese, R.Van Vollenhoven, K.C.Kalunian, S.Manzi, M.W.Greenwald, J.P.Buyon, N.J.Olsen, M.H.Schiff, A.F.Kavanaugh, J.R.Caldwell, R.Ramsey-Goldman, E.W.St Clair, A.L.Goldman, R.M.Egan, R.P.Polisson, K.G.Moder, N.F.Rothfield, R.T.Spencer, K.Hobbs, B.J.Fessler, L.H.Calabrese, L.W.Moreland, S.B.Cohen, B.J.Quarles, V.Strand, M.Gurwith, and K.E.Schwartz. 2004. Effects of prasterone on disease activity and symptoms in women with active systemic lupus erythematosus. Arthritis Rheum 50:2858-2868. [Abstract]

Wollaston,S.J., V.T.Farewell, D.A.Isenberg, C.Gordon, J.T.Merrill, M.A.Petri, and K.C.Kalunian. 2004. Defining response in systemic lupus erythematosus: a study by the Systemic Lupus International Collaborating Clinics group. J Rheumatol. 31:2390-2394. [Abstract]

Comparative Medicine/LARC

* Booth,J.L., K.M.Coggeshall, B.E.Gordon, and J.P.Metcalf. 2004. Adenovirus Type 7 Induces Interleukin-8 in a Lung Slice Model and Requires Activation of Erk. J.Virol. 78:4156-4164. [Abstract]

* Chang,W.P., G.Koelsch, S.Wong, D.Downs, H.Da, V.Weerasena, B.Gordon, T.Devasamudram, G.Bilcer, A.K.Ghosh, and J.Tang. 2004. In vivo inhibition of Abeta production by memapsin 2 (beta-secretase) inhibitors. J Neurochem. 89416. [Abstract]

Crystallography Research Program

Bourne,P.C., S.S.Terzyan, G.Cloud, N.F.Landolfi, M.Vasquez, and A.B.Edmundson. 2004. Three-dimensional structures of a humanized anti-IFN-gamma Fab (HuZAF) in two crystal forms. Acta Crystallogr.D Biol Crystallogr. 60:1761-1769. [Abstract]

Li,G.P. and X.J.C.Zhang. 2004. GTP hydrolysis mechanism of Ras-like GTPases. J Mol Biol 340:921-932. [Abstract]

Paul,S., S.Karle, S.Planque, H.Taguchi, M.Salas, Y.Nishiyama, B.Handy, R.Hunter, A.Edmundson, and C.Hanson. 2004. Naturally occurring proteolytic antibodies: Selective IgM-catalyzed hydrolysis of HIV gp120. J Biol Chem. 279: 39611-39619 [Abstract]

Planque,S., Y.Bangale, X.T.Song, S.Karle, H.Taguchi, B.Poindexter, R.Bick, A.Edmundson, Y.Nishiyama, and S.Paul. 2004. Ontogeny of proteolytic immunity – IgM serine proteases. J Biol Chem 279:14024-14032. [Abstract]

Terzyan,S., G.Zhu, G.Li, and X.C.Zhang. 2004. Refinement of the structure of human Rab5a GTPase domain at 1.05 A resolution. Acta Crystallogr.D.Biol.Crystallogr. 60:54-60. [Abstract]

Terzyan,S.S., H.A.Karapetyan, R.B.Sukiasyan, and A.M.Petrosyan. 2004. L-arginine nitrates. J Mol Struct 687:111-117.

Terzyan,S., P.A.Ramsland, E.W.Voss, Jr., J.N.Herron, and A.B.Edmundson. 2004. Three-dimensional structures of idiotypically related Fabs with intermediate and high affinity for fluorescein. J Mol Biol 339:1141-1151. [Abstract]

Terzyan,S., N.Wakeham, P.Zhai, K.Rodgers, and X.J.C.Zhang. 2004. Characterization of Lys-698 to Met substitution in human plasminogen catalytic domain. Proteins 56:277-284. [Abstract]

Zhang,Z., S.M.Lapolla, M.G.Annis, M.Truscott, G.J.Roberts, Y.W.Miao, Y.L.Shao, C.B.Tan, J.Peng, A.E.Johnson, X.J.C.Zhang, D.W.Andrews, and J.L.Lin. 2004. Bcl-2 homodimerization involves two distinct binding surfaces, a topographic arrangement that provides an effective mechanism for Bcl-2 to capture activated Bax. J Biol Chem 279:43920-43928. [Abstract]

* Zhu,G., P.Zhai, X.He, N.Wakeham, K.Rodgers, G.Li, J.Tang, and X.C.Zhang. 2004. Crystal structure of human GGA1 GAT domain complexed with the GAT-binding domain of Rabaptin5. EMBO J 23:3909-3917. {Abstract]

Zhu,G.Y., P.Zhai, J.Liu, S.Terzyan, G.P.Li, and X.J.C.Zhang. 2004. Structural basis of Rab5-Rabaptin5 interaction in endocytosis. Nat Struct Mol Biol 11:975-983. [Abstract]

Free Radical Biology and Aging Research Program

Floyd,R.A., J.E.Schneider, Jr., and D.P.Dittmer. 2004. Methylene blue photoinactivation of RNA viruses. Antiviral Res. 61:141-151. [Abstract]

Grammas,P., L.Hamdheydari, E.J.Benaksas, S.Mou, Q.N.Pye, W.J.Wechter, R.A.Floyd, C.Stewart, and K.Hensley. 2004. Anti-inflammatory effects of tocopherol metabolites. Biochem.Biophys.Res.Commun. 319:1047-1052. [Abstract]

Guo,W.X., Q.N.Pye, K.S.Williamson, C.A.Stewart, K.L.Hensley, Y.Kotake, R.A.Floyd, and R.H.Broyles. 2004. Reactive oxygen species in choline deficiency-induced apoptosis in rat hepatocytes. Free Radic.Biol Med. 37:1081-1089. [Abstract]

Hensley,K., E.J.Benaksas, R.Bolli, P.Comp, P.Grammas, L.Hamdheydari, S.Mou, Q.N.Pye, M.F.Stoddard, G.Wallis, K.S.Williamson, M.West, W.J.Wechter, and R.A.Floyd. 2004. New perspectives on vitamin E: gamma-tocopherol and carboxyethylhydroxychroman metabolites in biology and medicine Free Radic.Biol.Med. 36:1-15. [Abstract]

Kim,Y.T., R.Kurita, M.Kojima, W.Nishii, M.Tanokura, T.Muramatsu, H.Ito, and K.Takahashi. 2004. Identification of arginine residues important for the activity of Escherichia coli signal peptidase I. Biol Chem 385:381-388. [Abstract]

* Kurien,B.T., B.W.Pillow, Y.Dorri, K.Hensley, M.Bachman, and R.H.Scofield. 2004. SOD1 interacts directly with hemoglobin in vitro. Thromb.Haemost. 92:218-220. [Abstract]

Maples,K.R., A.R.Green, and R.A.Floyd. 2004. Nitrone-Related Therapeutics : Potential of NXY-059 for the Treatment of Acute Ischaemic Stroke. CNS.Drugs 18:1071-1084. [Abstract]

Mhatre,M., R.A.Floyd, and K.Hensley. 2004. Oxidative stress and neuroinflammation in Alzheimer’s disease and amyotrophic lateral sclerosis: Common links and potential therapeutic targets. J.Alzheimers.Dis. 6:147-157. [Abstract]

Mhatre,M., A.Nguyen, S.Kashani, T.Pham, A.Adesina, and P.Grammas. 2004. Thrombin, a mediator of neurotoxicity and memory impairment. Neurobiol.Aging 25:783-793. [Abstract]

Mhatre,M., R.Pruthi, K.Hensley, and F.Holloway. 2004. 5-HT(3) antagonist ICS 205-930 enhances naltrexone’s effects on ethanol intake. Eur.J.Pharmacol. 491:149-156. [Abstract]

Nakae,D., F.Uematsu, H.Kishida, O.Kusuoka, S.Katsuda, M.Yoshida, M.Takahashi, A.Maekawa, A.Denda, Y.Konishi, Y.Kotake, and R.A.Floyd. 2004. Inhibition of the development of hepatocellular carcinomas by phenyl N-tert-butyl nitrone in rats fed with a choline-deficient, l-amino acid-defined diet. Cancer Lett. 206:1-13. [Abstract]

Sueishi,Y., H.Tobisako, and Y.Kotake. 2004. Distinctive pressure effects on the association equilibrium in cyclodextrin group-inclusion complex as studied with electron paramagnetic resonance. J Phys Chem B 108:12623-12627.

Towner,R.A., C.Appleby, M.Levy, and T.M.Bray. 2004. Zinc deficiency and oxidative stress in brain: Magnetic resonance investigations in weanling rats. J Trace Elem Exp Med 17:161-174.

West,M., M.Mhatre, A.Ceballos, R.A.Floyd, P.Grammas, S.P.Gabbita, L.Hamdheydari, T.Mai, S.Mou, Q.N.Pye, C.Stewart, S.West, K.S.Williamson, F.Zemlan, and K.Hensley. 2004. The arachidonic acid 5-lipoxygenase inhibitor nordihydroguaiaretic acid inhibits tumor necrosis factor alpha activation of microglia and extends survival of G93A-SOD1 transgenic mice. J Neurochem. 91:133-143. [Abstract]

Yoshimura,T. and Y.Kotake. 2004. Spin trapping of nitric oxide with the iron-dithiocarbamate complex: chemistry and biology. Antioxid.Redox.Signal. 6:639-647. [Abstract]

Yoshioka,C., Y.Kotake, and Y.Sueishi. 2004. External pressure modulates spin-trapping rates in solution as studied with electron spin resonance. Chem Phys Lett 385:189-192.

Immunobiology and Cancer Research Program

Baba,Y., R.Pelayo, and P.W.Kincade. 2004. Relationships between hematopoietic stem cells and lymphocyte progenitors. Trends Immunol. 25:645-649. [Abstract]

* Booth,J.L., K.M.Coggeshall, B.E.Gordon, and J.P.Metcalf. 2004. Adenovirus Type 7 Induces Interleukin-8 in a Lung Slice Model and Requires Activation of Erk. J.Virol. 78:4156-4164. [Abstract]

Eltzschig HK, L.F.Thompson, J. Karhausen, R.J. Cotta, J.C. Ibla, S.C. Robson, and S.P. Colgan. 2004. Endogenous adenosine produced during hypoxia attenuates neutrophil accumulation: coordination by extracellular nucleotide metabolism. Blood 104:3986-3992. [Abstract]

Hashikawa,T., S.W.Hooker, J.G.Maj, C.J.Knott-Craig, M.Takedachi, S.Murakami, and L.F.Thompson. 2004. Regulation of adenosine receptor engagement by ecto-adenosine deaminase. FASEB J. 18:131-3. [Abstract]

Huang,Z., L.Nie, M.Xu, and X.H.Sun. 2004. Notch-Induced E2A Degradation Requires CHIP and Hsc70 as Novel Facilitators of Ubiquitination. Mol Cell Biol 24:8951-8962. [Abstract]

Hunter,M.G., A.Jacob, L.C.O’donnell, A.Agler, L.J.Druhan, K.M.Coggeshall, and B.R.Avalos. 2004. Loss of SHIP and CIS recruitment to the granulocyte colony-stimulating factor receptor contribute to hyperproliferative responses in severe congenital neutropenia/acute myelogenous leukemia. J Immunol. 173:5036-5045. [Abstract]

Kawakami,M., T.Kimura, Y.Kishimoto, T.Tatekawa, Y.Baba, T.Nishizaki, N.Matsuzaki, Y.Taniguchi, S.Yoshihara, K.Ikegame, T.Shirakata, S.Nishida, T.Masuda, N.Hosen, A.Tsuboi, Y.Oji, Y.Oka, H.Ogawa, Y.Sonoda, H.Sugiyama, I.Kawase, and T.Soma. 2004. Preferential expression of the vasoactive intestinal peptide (VIP) receptor VPAC1 in human cord blood-derived CD34(+)CD38(-) cells: possible role of VIP as a growth-promoting factor for hematopoietic stem/progenitor cells. Leukemia 18:912-921. [Abstract]

Nakamura,K., T.Kouro, P.W.Kincade, A.Malykhin, K.Maeda, and K.M.Coggeshall. 2004. Src Homology 2-containing 5-Inositol Phosphatase (SHIP) Suppresses an Early Stage of Lymphoid Cell Development through Elevated Interleukin-6 Production by Myeloid Cells in Bone Marrow. J.Exp.Med. 199:243-254. [Abstract]

Nixon,J.C., J.Rajaiya, and C.F.Webb. 2004. Mutations in the DNA-binding domain of the transcription factor, bright, act as dominant negative proteins and interfere with immunoglobulin transactivation. J Biol Chem. 279: 52465-52472. [Abstract]

Nixon,J.C., J.B.Rajaiya, N.Ayers, S.Evetts, and C.F.Webb. 2004. The transcription factor, Bright, is not expressed in all human B lymphocyte subpopulations. Cell Immunol. 228:42-53. [Abstract]

Qi,Z. and X.H.Sun. 2004. Hyperresponse to T-cell receptor signaling and apoptosis of id1 transgenic thymocytes. Mol Cell Biol 24:7313-7323. [Abstract]

Sun,X.H. 2004. Multitasking of helix-loop-helix proteins in lymphopoiesis. Adv.Immunol. 84:43-77.

Thompson,L.F., H.K.Eltzschig, J.C.Ibla, C.J.Van De Wiele, R.Resta, J.C.Morote-Garcia, and S.P.Colgan. 2004. Crucial Role for Ecto-5′-Nucleotidase (CD73) in Vascular Leakage during Hypoxia. J Exp Med 200:1395-1405. [Abstract]

Lipid Studies

Kolmakova,A., P.Kwiterovich, D.Virgil, P.Alaupovic, C.Knight-Gibson, S.F.Martin, and S.Chatterjee. 2004. Apolipoprotein C-I Induces Apoptosis in Human Aortic Smooth Muscle Cells via Recruiting Neutral Sphingomyelinase. Arterioscler.Thromb.Vasc.Biol. 24: 264-9. [Abstract]

Lee,E.T., M.Begum, W.Wang, P.R.Blackett, K.S.Blevins, M.Stoddart, B.Tolbert, and P.Alaupovic. 2004. Type 2 diabetes and impaired fasting glucose in American Indians aged 5-40 years: the Cherokee diabetes study. Ann.Epidemiol. 14:696-704. [Abstract]

Molecular, Cell and Developmental Biology Research Program

Beardmore,V.A., L.J.Ahonen, G.J.Gorbsky, and M.J.Kallio. 2004. Survivin dynamics increases at centromeres during G2/M phase transition and is regulated by microtubule-attachment and Aurora B kinase activity. J Cell Sci. 117:4033-42. [Abstract]

Bidlack,J.E. and P.M.Silverman. 2004. An active type IV secretion system encoded by the F plasmid sensitizes Escherichia coli to bile salts. J Bacteriol 186:5202-5209. [Abstract]

Bretschneider,T., S.Diez, K.Anderson, J.Heuser, M.Clarke, A.Muller-Taubenberger, J.Kohler, and G.Gerisch. 2004. Dynamic actin patterns and Arp2/3 assembly at the substrate-attached surface of motile cells. Curr.Biol. 14:1-10. [Abstract]

Burkeen,A.K., S.L.Maday, K.K.Rybicka, J.A.Sulcove, J.Ward, M.M.Huang, R.Barstead, C.Franzini-Armstrong, and T.S.Allen. 2004. Disruption of Caenorhabditis elegans Muscle Structure and Function Caused by Mutation of Troponin I. Biophys.J. 86:991-1001. [Abstract]

Chen,J., K.S.de Felipe, M.Clarke, H.Lu, O.R.Anderson, G.Segal, and H.A.Shuman. 2004. Legionella effectors that promote nonlytic release from protozoa. Science 303:1358-1361. [Abstract]

Clarke,M. and L.Maddera. 2004. Distribution of alkaline phosphatase in vegetative dictyostelium cells in relation to the contractile vacuole complex. Eur.J Cell Biol 83:289-296. [Abstract]

Coluccio,A., E.Bogengruber, M.N.Conrad, M.E.Dresser, P.Briza, and A.M.Neiman. 2004. Morphogenetic Pathway of Spore Wall Assembly in Saccharomyces cerevisiae. Eukaryot.Cell 3:1464-1475. [Abstract]

Costa,J.L., S.Bui, P.Reed, R.M.Dores, M.B.Brennan, and U.Hochgeschwender. 2004. Mutational analysis of evolutionarily conserved ACTH residues. Gen.Comp Endocrinol. 136:12-16. [Abstract]

Gorbsky,G.J. 2004. Mitosis: MCAK under the Aura of Aurora B. Curr.Biol. 14:R346-R348. [Abstract]

Harris,R.L. and P.A.Silverman. 2004. Tra proteins characteristic of F-like type IV secretion systems constitute an interaction group by yeast two-hybrid analysis. J Bacteriol 186:5480-5485. [Abstract]

McCleland,M.L., M.J.Kallio, G.A.Barrett-Wilt, C.A.Kestner, J.Shabanowitz, D.F.Hunt, G.J.Gorbsky, and P.T.Stukenberg. 2004. The vertebrate Ndc80 complex contains Spc24 and Spc25 homologs, which are required to establish and maintain kinetochore-microtubule attachment. Curr Biol 14:131-137. [Abstract]

McDermott,J., Y.Zhao, and B.Sauer. 2004. A simple polymerase chain reaction screen for homologous targeting in embryonic stem cells. Anal Biochem 332:401-403. [Abstract]

Meza,I. and M.Clarke. 2004. Dynamics of endocytic traffic of Entamoeba histolytica revealed by confocal microscopy and flow cytometry. Cell Motil.Cytoskeleton 59:215-226. [Abstract]

Otto,G.P., M.Y.Wu, M.Clarke, H.Lu, O.R.Anderson, H.Hilbi, H.A.Shuman, and R.H.Kessin. 2004. Macroautophagy is dispensable for intracellular replication of Legionella pneumophila in Dictyostelium discoideum. Mol.Microbiol. 51:63-72. [Abstract]

Preza,C. and J.A.Conchello. 2004. Depth-variant maximum-likelihood restoration for three-dimensional fluorescence microscopy. J Opt.Soc.Am.A Opt.Image Sci.Vis. 21:1593-1601. [Abstract]

Rundle,D.R., G.J.Gorbsky, and L.Tsiokas. 2004. PKD2 interacts and co-localizes with mDia1 to mitotic spindles of dividing cells: Role of mDia1 in PKD2 localization to mitotic spindles. J.Biol.Chem. 279:29728-39. [Abstract]

Molecular Immunogenetics Research Program

Byrum,J., S.Jordan, S.T.Safrany, and W.Rodgers. 2004. Visualization of inositol phosphate-dependent mobility of Ku: depletion of the DNA-PK cofactor InsP6 inhibits Ku mobility. Nucleic Acids Res. 32:2776-2784. [Abstract]

Capra,J.D. 2004. Multiple genes, one polypeptide chain. J Immunol. 173:6501-6502. [Abstract]

Gordy,C., S.Mishra, and W.Rodgers. 2004. Visualization of antigen presentation by actin-mediated targeting of glycolipid-enriched membrane domains to the immune synapse of B cell APCs. J.Immunol. 172:2030-2038. [Abstract]

Kolar,G.R. and J.D.Capra. 2004. Ig V region restrictions in human chronic lymphocytic leukemia suggest some cases have a common origin. J.Clin.Invest 113:952-954. [Abstract]

Kolar,G.R. and J.D.Capra. 2004. Immunoglobulin heavy-chain receptor editing is observed in the NOD/SCID model of human B-cell development. Scand.J Immunol. 60:108-111. [Abstract]

Luo,C. and P.Laaja. 2004. Inhibitors of JAKs/STATs and the kinases: a possible new cluster of drugs. Drug Discov.Today 9:268-275. [Abstract]

Meffre,E., A.Schaefer, H.Wardemann, P.Wilson, E.Davis, and M.C.Nussenzweig. 2004. Surrogate Light Chain Expressing Human Peripheral B Cells Produce Self-reactive Antibodies. J.Exp.Med. 199:145-150. [Abstract]

Zheng, N.Y., K.Wilson, X.Wang, A.Boston, G.Kolar, S.M.Jackson, Y.J.Liu, V.Pascual, J.D.Capra, and P.C.Wilson. 2004. Human immunoglobulin selection associated with class switch and possible tolerogenic origins for C delta class-switched B cells. J.Clin.Invest 113:1188-1201. [Abstract]

Protein Studies Research Program

Hong,L., X.Y.He, X.P.Huang, W.P.Chang, and J.Tang. 2004. Structural Features of Human Memapsin 2 (beta-Secretase) and Their Biological and Pathological Implications. Acta Biochim.Biophys Sin.(Shanghai) 36:787-792. [Abstract]

Hong,L. and J.Tang. 2004. Flap position of free memapsin 2 (beta-secretase), a model for flap opening in aspartic protease catalysis. Biochemistry 43:4689-4695. [Abstract]

Kzhyshkowska,J., A.Gratchev, J.H.Martens, O.Pervushina, S.Mamidi, S.Johansson, K.Schledzewski, B.Hansen, X.He, J.Tang, K.Nakayama, and S.Goerdt. 2004. Stabilin-1 localizes to endosomes and the trans-Golgi network in human macrophages and interacts with GGA adaptors. J Leukoc.Biol. 76:1151-1161. [Abstract]

* Indicates publications by more than one department.

01/13/10

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