| Presenter | Topic | Location | |
| Aug. 28 | Introduction | ““ | MC-204 4:00 PM |
| Sept. 4 | Group 1: Non-Insulin Hormonal Regulation of Metabolism Megan Brophy, Jami Gurley, and Rachel Lane |
“Ghrelin is a growth-hormone-releasing acylated peptide from stomach” | MC-204 4:00 PM |
| Sept. 11 | Group | NO MEETING | MC-204 4:00 PM |
| Sept. 18 | Group 1: Non-Insulin Hormonal Regulation of Metabolism Megan Brophy, Rachel Lane |
“Hypothalamic Fatty Acid Metabolism Mediates the Orexigenic Action of Ghrelin” / second link | MC-204 4:00 PM |
| Sept. 25 | Group 1: Non-Insulin Hormonal Regulation of Metabolism Megan Brophy, Rachel Lane |
“Profound Hypoglycemia in Starved, Ghrelin-deficient Mice Is Caused by Decreased Gluconeogenesis and Reversed by Lactate or Fatty Acids” | MC-204 4:00 PM |
| Oct. 2 | Group 2: Metals and Metabolism Clair Crewe, Jolyn Fernandes, Yao Fu |
“Influence of Genetic Obesity on Tissue Concentrations of Zinc, Copper, Manganese and Iron in Mice” | MC-204 4:00 PM |
| Oct. 9 | Group 2: Metals and Metabolism Clair Crewe, Jolyn Fernandes, Yao Fu | “Adipocyte Iron Regulates Adiponectin and Insulin Sensitivity” | MC-204 4:00 PM |
| Oct. 16 | Group 2: Metals and Metabolism Clair Crewe, Jolyn Fernandes, Yao Fu |
“Iron regulates glucose homeostasis in liver and muscle via AMP-activated protein kinase in mice” | MC-204 4:00 PM |
| Oct. 23 | Group 3: ROS Myth-Busters Lee Bockus, Rob Jackson, Nan Zhang |
“Reactive Oxygen Species have a Causal Role in Multiple Forms of Insulin Resistance” | MC-204 4:00 PM |
| Oct. 30 | NO MEETING | HALLOWEEN | MC-204 4:00 PM |
| Nov. 6 | NO MEETING | ““ | MC-204 4:00 PM |
| Nov. 13 | NO MEETING | MC-204 4:00 PM |
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| Nov. 20 | Group 3: ROS Myth-Busters Lee Bockus, Rob Jackson, Nan Zhang |
“Reactive Oxygen Species Enhance Insulin Sensitivity” | MC-204 4:00 PM |
| Nov. 27 | NO MEETING: Thanksgiving Break | MC-204 4:00 PM |
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| Dec. 4 | Group 3: ROS Myth-Busters Lee Bockus, Rob Jackson, Nan Zhang |
“Heme Oxygenase-1 Drives Metaflammation and Insulin Resistance in Mouse and Man” | MC-204 4:00 PM |
| Dec. 11 | Wrap Up | MC-204 4:00 PM |
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| Jan. 6 | ““ | MC-204 4:00 PM |
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| Jan. 15 | Organizational Meeting | ““ | MC-204 4:00 PM |
| Jan. 22 | NO MEETING | ““ | MC-204 4:00 PM |
| Jan. 29 | NO MEETING | ““ | MC-204 4:00 PM |
| Feb 5 | Team Pro / Jami Gurley, Rachel Lane, Yao Fu, Clair Crewe | “Colocalization of MCT1, CD147, and LDH in mitochondrial inner membrane of L6 muscle cells: evidence of a mitochondrial lactate oxidation complex” | MC-204 4:00 PM |
| Feb 12 | Team Anti / Lee Bockus | “Negligible direct lactate oxidation in subsarcolemmal and intermyofibrillar mitochondria obtained from red and white rat skeletal muscle”Also, an optional read is a commentary about the first: click here. | MC-206 4:00 PM |
| Feb 19 | Team Pro / Jami Gurley, Rachel Lane, Yao Fu, Clair Crewe | “Physical and Functional Association of Lactate Dehydrogenase (LDH) with Skeletal Muscle Mitochondria” | MC-206 4:00 PM |
| Feb 26 | Team Anti / Rob Jackson, Megan Brophy, Lee Bockus, Jolyn Fernandes, Nan Zhang | “Direct evidence for activity-dependent glucose phosphorylation in neurons with implications for the astrocyte-to-neuron lactate shuttle“ | MC-206 4:00 PM |
| Feb. 27 | ““ | MC-206 4:00 PM |
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| Mar. 5 | Final Wrap-Up Session for Lactate Shuttle Topic | ““ | MC-206 4:00 PM |
| Mar. 12 | NO MEETING – OMRF Retreat | ““ | MC-206 4:00 PM |
| Mar. 19 | NO MEETING – Spring Break | MC-206 4:00 PM |
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| Mar. 26 | Prep for Topic #2 on your own | MC-206 4:00 PM |
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| Apr. 2 | NO MEETING – OUHSC Great Symposium (continue to prep on your own) | MC-206 4:00 PM |
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| Apr. 9 | Team Pro Ceramide: Rob Jackson, Rachel Lane, Lee Bockus, Clair Crewe, Jolyn Fernandes, Yao Fu | “Prevention of hepatic steatosis and hepatic insulin resistance in mitochondrial acyl-CoA:glycerol-sn-3-phosphate acyltransferase 1 knockout mice.” | MC-206 4:00 PM |
| Apr. 16 | Team Pro Ceramide: Rob Jackson, Rachel Lane, Yao Fu, Lee Bockus, Clair Crewe | “Regulation of insulin-stimulated glucose transporter GLUT4 translocation and Akt kinase activity by ceramide” | MC-206 4:00 PM |
| Apr. 23 | Team Pro DAG: Jolyn Fernandes, Megan Brophy, Jami Gurley, Nan Zhang | “Saturated and unsaturated fat induce hepatic insulin resistance independently of TLR-4 signaling and ceramide synthesis in vivo“ | MC-206 4:00 PM |
| Apr. 30 | Team Pro Ceramide: Rob Jackson, Rachel Lane, Lee Bockus, Clair Crewe, Yao Fu | “Obesity-Induced CerS6-Dependent C16:0 Ceramide Production Promotes Weight Gain and Glucose Intolerance” | MC-206 4:00 PM |
| May 7 | WRAP UP: Ceramide vs DAG topic |
The first paper will be the primary focus of the JC.
The second paper will be referencial and briefly summarized at the end as a followup. |
MC-206 4:00 PM |
| MC-206 4:00 PM |
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| MC-206 4:00 PM |
The Free Radical Biology & Aging Metabolic Regulation Journal Club meets on Thursdays from 4:00 p.m. to 5:00 p.m. in MC-206, unless otherwise posted. To sign up for a particular date contact Tim Griffin at griffint@omrf.org or 271-7579.
