2013 Scientific Publications

Advanced Magnetic Resonance Center

* Floyd RA, Castro Faria Neto HC, Zimmerman GA, Hensley K, Towner RA. Nitrone-based Therapeutics for Neurodegenerative Diseases. Their use alone or in Combination with Lanthionines. Free Radic Biol Med 62:145-156,2013. [Abstract]

* Garteiser P, Doblas S, Towner RA, Griffin TM. Calibration of a semi-automated segmenting method for quantification of adipose tissue compartments from magnetic resonance images of mice. Metabolism 62:1686-1695, 2013. [Abstract]

* He T, Smith N, Saunders D, Pittman BP, Lerner M, Lightfoot S, Silasi-Mansat R, Lupu F, Towner RA. Molecular MRI differentiation of VEGF receptor-2 levels in C6 and RG2 glioma models. Am J Nucl Med Mol Imaging 3:300-311, 2013. [Abstract]

Piao D, Towner RA, Smith N, Chen WR. Magnetothermoacoustics from magnetic nanoparticles by short bursting or frequency chirped alternating magnetic field: A theoretical feasibility analysis. Med Phys 40:063301, 2013. [Abstract]

* Towner RA, Garteiser P, Bozza F, Smith N, Saunders D, d’Avila JC, Magno F, Oliveira MF, Ehrenshaft M, Lupu F, Silasi-Mansat R, Ramirez DC, Gomez-Mejiba SE, Mason RP, Faria-Neto HC. In Vivo Detection of Free Radicals in Mouse Septic Encephalopathy using Molecular MRI and Immuno-Spin-Trapping. Free Radic Biol Med 65C:828-837, 2013. [Abstract]

* Towner RA, Gillespie DL, Schwager A, Saunders DG, Smith N, Njoku CE, Krysiak RS, III, Larabee C, Iqbal H, Floyd RA, Bourne DW, Abdullah O, Hsu EW, Jensen RL. Regression of glioma tumor growth in F98 and U87 rat glioma models by the Nitrone OKN-007. Neuro Oncol 15:330-340, 2013. [Abstract]

* Towner RA, Jensen RL, Colman H, Vaillant B, Smith N, Casteel R, Saunders D, Gillespie DL, Silasi-Mansat R, Lupu F, Giles CB, Wren JD. ELTD1, A Potential new biomarker for gliomas. Neurosurgery 72:77-791, 2013. [Abstract]

* Towner RA, Jensen RL, Vaillant B, Colman H, Saunders D, Giles CB, Wren JD. Experimental validation of 5 in-silico predicted glioma biomarkers. Neuro Oncol 15:1625-1634,2013. [Abstract]

* Towner RA, Smith N, Saunders D, De Souza PC, Henry L, Lupu F, Silasi-Mansat R, Ehrenshaft M, Mason RP, Gomez-Mejiba SE, Ramirez DC. Combined Molecular MRI and Immuno-Spin-Trapping for in vivo Detection of Free Radicals in Orthotopic Mouse GL261 Gliomas. Biochim Biophys Acta 1832:2153-2161,2013. [Abstract]

* Towner RA, Smith N, Saunders D, Lupu F, Silasi-Mansat R, West M, Ramirez DC, Gomez-Mejiba SE, Bonini MG, Mason RP, Ehrenshaft M, Hensley K. In Vivo Detection of Free Radicals using Molecular MRI and Immuno-Spin-Trapping in a Mouse Models for Amyotrophic Lateral Sclerosis (ALS). Free Radic Biol Med 63:351-360, 2013. [Abstract]

Arthritis and Clinical Immunology Research Program

Adler AJ, Wiley GB, Gaffney PM. Infinium Assay for Large-scale SNP Genotyping Applications. J Vis Exp (81):e50683, 2013. [Abstract]

Aggarwal R, Sestak AL, Chakravarty EF, Harley JB, Scofield RH. Excess Female Siblings and Male Fetal Loss in Families with Systemic Lupus Erythematosus. J Rheumatol 40:430-434, 2013. [Abstract]

American College of Rheumatology Committee on Rheumatology Training and Workforce, Fitzgerald JD, Battistone M, Brown CR, Jr., Cannella AC, Chakravarty E, Gelber AC, Lozada CJ, Punaro M, Slusher B, Abelson A, Elashoff DA, Benford L. Regional distribution of adult rheumatologists. Arthritis Rheum 65:3017-3025, 2013. [Abstract]

Andrews SF, Zhang Q, Lim S, Li L, Lee JH, Zheng NY, Huang M, Taylor WM, Farris AD, Ni D, Meng W, Luning Prak ET, Wilson PC. Global analysis of B cell selection using an immunoglobulin light chain-mediated model of autoreactivity. J Exp Med 210:125-142,2013. [Abstract]

Belot A, Kasher PR, Trotter EW, Foray AP, Debaud AL, Rice GI, Szynkiewicz M, Zabot MT, Rouvet I, Bhaskar SS, Daly SB, Dickerson JE, Mayer J, O’Sullivan J, Juillard L, Urquhart JE, Fawdar S, Marusiak AA, Stephenson N, Waszkowycz B, Beresford MW, Biesecker LG, Black GM, Rene C, Eliaou JF, Fabien N, Ranchin B, Cochat P, Gaffney PM, Rozenberg F, Lebon P, Malcus C, Crow YJ, Brognard J, Bonnefoy N. Protein kinase C delta deficiency causes mendelian systemic lupus erythematosus with B-cell defective apoptosis and hyperproliferation. Arthritis Rheum 65:2161-2171, 2013. [Abstract]

Bernal-Quiros M, Wu YY, Alarcon-Riquelme ME, Castillejo-Lopez C. BANK1 and BLK act through phospholipase C gamma 2 in B-cell signaling. PLoS One 8:e59842, 2013. [Abstract]

Bushara K, Bower M, Liu J, McFarland KN, Landrian I, Hutter D, Teive HA, Rasmussen A, Mulligan CJ, Ashizawa T. Expansion of the Spinocerebellar Ataxia Type 10 (SCA10) Repeat in a Patient with Sioux Native American Ancestry. PLoS One 8:e81342, 2013. [Abstract]

Buyyarapu R, Kantety RV, Yu JZ, Xu Z, Kohel RJ, Percy RG, Macmil S, Wiley GB, Roe BA, Sharma GC. BAC-Pool Sequencing and Analysis of Large Segments of A12 and D12 Homoeologous Chromosomes in Upland Cotton. PLoS One 8:e76757, 2013. [Abstract]

* Caster DJ, Korte EA, Nanda SK, McLeish KR, Oliver RK, G’sell RT, Sheehan RM, Freeman DW, Coventry SC, Kelly JA, Guthridge JM, James JA, Sivils KL, Alarcon-Riquelme ME, Scofield RH, Adrianto I, Gaffney PM, Stevens AM, Freedman BI, Langefeld CD, Tsao BP, Pons-Estel BA, Jacob CO, Kamen DL, Gilkeson GS, Brown EE, Alarcon GS, Edberg JC, Kimberly RP, Martin J, Merrill JT, Harley JB, Kaufman KM, Reveille JD, Anaya JM, Criswell LA, Vila LM, Petri M, Ramsey-Goldman R, Bae SC, Boackle SA, Vyse TJ, Niewold TB, Cohen P, Powell DW. ABIN1 Dysfunction as a Genetic Basis for Lupus Nephritis. J Am Soc Nephrol 24:1743-1754, 2013. [Abstract]

Centola M, Cavet G, Shen Y, Ramanujan S, Knowlton N, Swan KA, Turner M, Sutton C, Smith DR, Haney DJ, Chernoff D, Hesterberg LK, Carulli JP, Taylor PC, Shadick NA, Weinblatt ME, Curtis JR. Development of a multi-biomarker disease activity test for rheumatoid arthritis. PLoS One 8:e60635, 2013. [Abstract]

Chakravarty E, Michaud K, Katz R, Wolfe F. Increased incidence of herpes zoster among patients with systemic lupus erythematosus. Lupus 22:238-0244, 2013. [Abstract]

Chaudhry MA, Scofield RH. Atypical rocky mountain spotted Fever with polyarticular arthritis. Am J Med Sci 346:427-429, 2013. [Abstract]

* Coggeshall KM, Lupu F, Ballard J, Metcalf JP, James JA, Farris D, Kurosawa S. The sepsis model: an emerging hypothesis for the lethality of inhalation anthrax. J Cell Mol Med 17:914-920, 2013. [Abstract]

Cogman AR, Chakravarty EF. The case for Zostavax vaccination in systemic lupus erythematosus. Vaccine 31:3640-3643, 2013. [Abstract]

* Coit P, Jeffries M, Altorok N, Dozmorov MG, Koelsch KA, Wren JD, Merrill JT, McCune WJ, Sawalha AH. Genome-wide DNA methylation study suggests epigenetic accessibility and transcriptional poising of interferon-regulated genes in naive CD4+ T cells from lupus patients. J Autoimmun 43:78-84, 2013. [Abstract]

Davis NA, Lareau CA, White BC, Pandey A, Wiley G, Montgomery CG, Gaffney PM, McKinney BA. Encore: Genetic Association Interaction Network Centrality Pipeline and Application to SLE Exome Data. Genet Epidemiol 37:614-621, 2013. [Abstract]

* Deng Y, Zhao J, Sakurai D, Kaufman KM, Edberg JC, Kimberly RP, Kamen DL, Gilkeson GS, Jacob CO, Scofield RH, Langefeld CD, Kelly JA, Ramsey-Goldman R, Petri MA, Reveille JD, Vila LM, Alarcon GS, Vyse TJ, Pons-Estel BA, Argentine Collaborative Group, Freedman BI, Gaffney PM, Sivils KM, James JA, Gregersen PK, Anaya JM, Niewold TB, Merrill JT, Criswell LA, Stevens AM, Boackle SA, Cantor RM, Chen W, Grossman JM, Hahn BH, Harley JB, Alarcon-Riquelme ME, BIOLUPUS and GENLES Networks, Brown EE, Tsao BP. MicroRNA-3148 Modulates Allelic Expression of Toll-Like Receptor 7 Variant Associated with Systemic Lupus Erythematosus. PLoS Genet 9:e1003336, 2013. [Abstract]

Deshmukh US, Bagavant H. When killers become helpers. Sci Transl Med 5:195fs29, 2013. [Abstract]

Ding C, Ma Y, Chen X, Liu M, Cai Y, Hu X, Xiang D, Nath S, Zhang HG, Ye H, Powell D, Yan J. Integrin CD11b negatively regulates BCR signalling to maintain autoreactive B cell tolerance. Nat Commun 4:2813, 2013. [Abstract]

Dozmorov I, Dominguez N, Sestak AL, Robertson JM, Harley JB, James JA, Guthridge JM. Evidence of dynamically dysregulated gene expression pathways in hyperresponsive B cells from African American lupus patients. PLoS One 8:e71397, 2013. [Abstract]

Dozmorov MG, Giles CB, Koelsch KA, Wren JD. Systematic classification of non-coding RNAs by epigenomic similarity. BMC Bioinformatics 14 Suppl 14:S2, 2013. [Abstract]

Dumas EK, Nguyen ML, Cox PM, Rodgers H, Peterson JL, James JA, Farris AD. Stochastic humoral immunity to Bacillus anthracis protective antigen: Identification of anti-peptide IgG correlating with seroconversion to Lethal Toxin neutralization. Vaccine 31:1856-1863,2013. [Abstract]

Giles CB, Girija-Devi R, Dozmorov MG, Wren JD. mirCoX: a database of miRNA-mRNA expression correlations derived from RNA-seq meta-analysis. BMC Bioinformatics 14 Suppl 14:S17, 2013. [Abstract]

* Guthridge JM, Cogman A, Merrill JT, Macwana S, Bean KM, Powe T, Roberts V, James JA, Chakravarty EF. Herpes Zoster Vaccination in SLE: A Pilot Study of Immunogenicity. J Rheumatol 40:1875-1880, 2013. [Abstract]

Hinks A, Cobb J, Marion MC, Prahalad S, Sudman M, Bowes J, Martin P, Comeau ME, Sajuthi S, Andrews R, Brown M, Chen WM, Concannon P, Deloukas P, Edkins S, Eyre S, Gaffney PM, Guthery SL, Guthridge JM, Hunt SE, James JA, Keddache M, Moser KL, Nigrovic PA, Onengut-Gumuscu S, Onslow ML, Rose CD, Rich SS, Steel KJ, Wakeland EK, Wallace CA, Wedderburn LR, Woo P, Boston Children’s JIA Registry, British Society of Paediatric and Adolescent Rheumatology (BSPAR) Study Group, Childhood Arthritis Prospective Study (CAPS), Childhood Arthritis Response to Medication Study (CHARMS), German Society for Pediatric Rheumatology (GKJR), JIA Gene Expression Study, NIAMS JIA Genetic Registry, TREAT Study, United Kingdom Juvenile Idiopathic Arthritis Genetics Consortium (UKJIAGC), Bohnsack JF, Haas JP, Glass DN, Langefeld CD, Thomson W, Thompson SD. Dense genotyping of immune-related disease regions identifies 14 new susceptibility loci for juvenile idiopathic arthritis. Nat Genet 45:664-669, 2013. [Abstract]

Hirata S, Dirven L, Shen Y, Centola M, Cavet G, Lems WF, Tanaka Y, Huizinga TW, Allaart CF. A multi-biomarker score measures rheumatoid arthritis disease activity in the BeSt study. Rheumatology (Oxford) 52:1202-1207, 2013. [Abstract]

Hughes T, Coit P, Adler A, Yilmaz V, Aksu K, Duzgun N, Keser G, Cefle A, Yazici A, Ergen A, Alpsoy E, Salvarani C, Casali B, Kotter I, Gutierrez-Achury J, Wijmenga C, Direskeneli H, Saruhan-Direskeneli G, Sawalha AH. Identification of multiple independent susceptibility loci in the HLA region in Behcet’s disease. Nat Genet 45:319-324, 2013. [Abstract]

Hurst RE, Hauser PJ, Kyker KD, Heinlen JE, Hodde JP, Hiles MC, Kosanke SD, Dozmorov M, Ihnat MA. Suppression and Activation of the Malignant Phenotype by Extracellular Matrix in Xenograft Models of Bladder Cancer: A Model for Tumor Cell “Dormancy”. PLoS One 8:e64181, 2013. [Abstract]

* Hu T, Wang H, Simmons A, Bajana S, Zhao Y, Kovats S, Sun XH, Alberola-Ila J. Increased Level of E Protein Activity during Invariant NKT Development Promotes Differentiation of Invariant NKT2 and Invariant NKT17 Subsets. J Immunol 191:5065-5073, 2013. [Abstract]

Igoe A, Scofield RH. Autoimmunity and infection in Sjogren’s syndrome. Curr Opin Rheumatol 25:480-487, 2013. [Abstract]

James JA, Danda D. New perspectives and insights to Asian systemic lupus erythematosus: renal disease, genetic predisposition and disease activity. Int J Rheum Dis 16:611-614, 2013. [Abstract]

* Kaufman KM, Zhao J, Kelly JA, Hughes T, Adler A, Sanchez E, Ojwang JO, Langefeld CD, Ziegler JT, Williams AH, Comeau ME, Marion MC, Glenn SB, Cantor RM, Grossman JM, Hahn BH, Song YW, Yu CY, James JA, Guthridge JM, Brown EE, Alarcon GS, Kimberly RP, Edberg JC, Ramsey-Goldman R, Petri MA, Reveille JD, Vila LM, Anaya JM, Boackle SA, Stevens AM, Freedman BI, Criswell LA, Pons-Estel BA, on behalf of the Argentine Collaborative Group, Lee JH, Lee JS, Chang DM, Scofield RH, Gilkeson GS, Merrill JT, Niewold TB, Vyse TJ, Bae SC, Alarcon-Riquelme ME, on behalf of the BIOLUPUS network, Jacob CO, Sivils KM, Gaffney PM, Harley JB, Sawalha AH, Tsao BP. Fine mapping of Xq28: both MECP2 and IRAK1 contribute to risk for systemic lupus erythematosus in multiple ancestral groups. Ann Rheum Dis 72:437-444, 2013. [Abstract]

Koelsch KA, Wang Y, Maier-Moore JS, Sawalha AH, Wren JD. GFP Affects Human T Cell Activation and Cytokine Production following In Vitro Stimulation. PLoS One 8:e50068, 2013. [Abstract]

Koelsch KA, Webb R, Jeffries M, Dozmorov MG, Frank MB, Guthridge JM, James JA, Wren JD, Sawalha AH. Functional characterization of the MECP2/IRAK1 lupus risk haplotype in human T cells and a human MECP2 transgenic mouse. J Autoimmun 41:168-174, 2013. [Abstract]

Kurien BT, Dsouza A, Igoe A, Lee YJ, Maier-Moore JS, Gordon T, Jackson M, Scofield RH. Immunization with 60 kD Ro peptide produces different stages of pre-clinical autoimmunity in a Sjogren’s syndrome-model among multiple strains of inbred mice. Clin Exp Immunol 173:67-75, 2013.[Abstract]

Kurien BT, D’Sousa A, Bruner BF, Gross T, James JA, Targoff IN, Maier-Moore JS, Harley IT, Wang H, Scofield RH. Prolidase deficiency breaks tolerance to lupus-associated antigens. Int J Rheum Dis 16:674-680, 2013. [Abstract]

Lanis JM, Heinlen LD, James JA, Ballard JD. Clostridium difficile 027/BI/NAP1 Encodes a Hypertoxic and Antigenically Variable Form of TcdB. PLoS Pathog 9:e1003523, 2013. [Abstract]

Lessard CJ, Li H, Adrianto I, Ice JA, Rasmussen A, Grundahl KM, Kelly JA, Dozmorov MG, Miceli-Richard C, Bowman S, Lester S, Eriksson P, Eloranta ML, Brun JG, Goransson LG, Harboe E, Guthridge JM, Kaufman KM, Kvarnstrom M, Jazebi H, Graham DS, Grandits ME, Nazmul-Hossain AN, Patel K, Adler AJ, Maier-Moore JS, Farris AD, Brennan MT, Lessard JA, Chodosh J, Gopalakrishnan R, Hefner KS, Houston GD, Huang AJ, Hughes PJ, Lewis DM, Radfar L, Rohrer MD, Stone DU, Wren JD, Vyse TJ, Gaffney PM, James JA, Omdal R, Wahren-Herlenius M, Illei GG, Witte T, Jonsson R, Rischmueller M, Ronnblom L, Nordmark G, Ng WF, for UK Primary Sjogren’s Syndrome Registry, Mariette X, Anaya JM, Rhodus NL, Segal BM, Scofield RH, Montgomery CG, Harley JB, Sivils KL. Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjogren’s syndrome. Nat Genet 45:1284-1292, 2013. [Abstract]

Lester S, Stokes L, Skarratt KK, Gu BJ, Sivils KL, Lessard CJ, Wiley JS, Rischmueller M. Epistasis with HLA DR3 implicates the P2X7 receptor in the pathogenesis of primary Sjogren’s syndrome. Arthritis Res Ther 15:R71, 2013. [Abstract]

Levin AM, Iannuzzi MC, Montgomery CG, Trudeau S, Datta I, McKeigue P, Fischer A, Nebel A, Rybicki BA. Association of ANXA11 genetic variation with sarcoidosis in African Americans and European Americans. Genes Immun 14:13-18,2013. [Abstract]

Li H, Ice JA, Lessard CJ, Sivils KL. Interferons in Sjogren’s Syndrome: Genes, Mechanisms, and Effects. Front Immunol 4:290, 2013. [Abstract]

Li H, Zuccolo J, Kem DC, Zillner C, Lee J, Smith K, James JA, Cunningham MW, Yu X. Implications of a vasodilatory human monoclonal autoantibody in postural hypotension. J Biol Chem 288:30734-30741, 2013. [Abstract]

López Herráez D, Martínez-Bueno M, Riba L, García de la Torre I, Sacnún M, Goñi M, Berbotto GA, Paira S, Musuruana JL, Graf C, Alvarellos A, Messina OD, Babini A, Strusberg I, Marcos JC, Scherbarth H, Spindler A, Quinteros A, Toloza S, Moreno JL, Catoggio LJ, Tate G, Eimon A, Citera G, Catalán Pellet A, Nasswetter GG, Cardiel MH, Miranda P, Ballesteros F, Esquivel-Valerio JA, Maradiaga-Ceceña MA, Acevedo-Vásquez EM, García García C, Pons-Estel, A., Alarcón-Riquelme M. Rheumatoid arthritis in Latin Americans enriched for Amerindian ancestry is associated with loci in chromosomes 1, 12,13, and HLA class II region. Arthritis Rheum 65:1457-1467, 2013. [Abstract]

Ma H, Thapa A, Morris LM, Michalakis S, Biel M, Frank MB, Bebak M, Ding XQ. Loss of cone cyclic nucleotide-gated channel leads to alterations in light response modulating system and cellular stress response pathways: a gene expression profiling study. Hum Mol Genet 22:3906-3919, 2013. [Abstract]

Maier-Moore JS, Canas CA, Tobon G, Arango A, Anaya JM, Scofield RH. The CCR5 delta 32 polymorphism (rs333) is not associated with Sjogren’s syndrome or Type 1 Diabetes in Colombians. Clin Immunol 148:206-208, 2013. [Abstract]

Maiti AK, Nath SK. Gene network analysis of small molecules with autoimmune disease associated genes predicts a novel strategy for drug efficacy. Autoimmun Rev 12:510-522,2013. [Abstract]

Mamyrova G, Katz JD, Jones RV, Targoff IN, Lachenbruch PA, Jones OY, Miller FW, Rider LG, Childhood Myositis Heterogeneity Collaborative Study Group. Clinical and laboratory features distinguishing juvenile polymyositis and muscular dystrophy. Arthritis Care Res (Hoboken) 65:1969-1975, 2013. [Abstract]

Mangale D, Kariuki SN, Chrabot BS, Kumabe M, Kelly JA, Harley JB, James JA, Sivils KL, Niewold TB. Familial aggregation of high tumor necrosis factor alpha levels in systemic lupus erythematosus. Clin Dev Immunol 2013:267430, 2013. [Abstract]

* Manku H, Langefeld CD, Guerra SG, Malik TH, Alarcon-Riquelme M, Anaya JM, Bae SC, Boackle SA, Brown EE, Criswell LA, Freedman BI, Gaffney PM, Gregersen PA, Guthridge JM, Han SH, Harley JB, Jacob CO, James JA, Kamen DL, Kaufman KM, Kelly JA, Martin J, Merrill JT, Moser KL, Niewold TB, Park SY, Pons-Estel BA, Sawalha AH, Scofield RH, Shen N, Stevens AM, Sun C, Gilkeson GS, Edberg JC, Kimberly RP, Nath SK, Tsao BP, Vyse TJ. Trans-Ancestral Studies Fine Map the SLE-Susceptibility Locus TNFSF4. PLoS Genet 9:e1003554, 2013. [Abstract]

Marabelle A, Kohrt H, Sagiv-Barfi I, Ajami B, Axtell RC, Zhou G, Rajapaksa R, Green MR, Torchia J, Brody J, Luong R, Rosenblum MD, Steinman L, Levitsky HI, Tse V, Levy R. Depleting tumor-specific Tregs at a single site eradicates disseminated tumors. J Clin Invest 123:4980, 2013. [Abstract]

Martin JE, Assassi S, Diaz-Gallo LM, Broen JC, Simeon CP, Castellvi I, Vicente-Rabaneda E, Fonollosa V, Ortego-Centeno N, Gonzalez-Gay MA, Espinosa G, Carreira P, Spanish Scleroderma Group, SLEGEN Consortium, U.S.Scleroderma GWAS group, BIOLUPUS, Camps M, Sabio JM, D’Alfonso S, Vonk MC, Voskuyl AE, Schuerwegh AJ, Kreuter A, Witte T, Riemekasten G, Hunzelmann N, Airo P, Beretta L, Scorza R, Lunardi C, van LJ, Chee MM, Worthington J, Herrick A, Denton C, Fonseca C, Tan FK, Arnett F, Zhou X, Reveille JD, Gorlova O, Koeleman BP, Radstake TR, Vyse T, Mayes MD, Alarcón-Riquelme ME, Martin J. A Systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci. Hum Mol Genet 22:4021-4029,2013. [Abstract]

McFarland KN, Liu J, Landrian I, Gao R, Sarkar PS, Raskin S, Moscovich M, Gatto EM, Teive HA, Ochoa A, Rasmussen A, Ashizawa T. Paradoxical effects of repeat interruptions on spinocerebellar ataxia type 10 expansions and repeat instability. Eur J Hum Genet 21:1272-1276, 2013. [Abstract]

McKeigue PM, Colombo M, Agakov F, Datta I, Levin A, Favro D, Gray-Montgomery C, Iannuzzi MC, Rybicki BA. Extending admixture mapping to nuclear pedigrees: application to sarcoidosis. Genet Epidemiol 37:256-266, 2013. [Abstract]

* Molineros JE, Maiti AK, Sun C, Looger LL, Han S, Kim-Howard X, Glenn S, Adler A, Kelly JA, Niewold TB, Gilkeson GS, Brown EE, Alarcon GS, Edberg JC, Petri M, Ramsey-Goldman R, Reveille JD, Vila LM, Freedman BI, Tsao BP, Criswell LA, Jacob CO, Moore JH, Vyse TJ, Langefeld CL, Guthridge JM, Gaffney PM, Moser KL, Scofield RH, Alarcon-Riquelme ME, BIOLUPUS Network, Williams SM, Merrill JT, James JA, Kaufman KM, Kimberly RP, Harley JB, Nath SK. Admixture Mapping in Lupus Identifies Multiple Functional Variants within IFIH1 Associated with Apoptosis, Inflammation, and Autoantibody Production. PLoS Genet 9:e1003222, 2013. [Abstract]

* Namjou B, Kim-Howard X, Sun C, Adler A, Chung SA, Kaufman KM, Kelly JA, Glenn SB, Guthridge JM, Scofield RH, Kimberly RP, Brown EE, Alarcon GS, Edberg JC, Kim JH, Choi J, Ramsey-Goldman R, Petri MA, Reveille JD, Vila LM, Boackle SA, Freedman BI, Tsao BP, Langefeld CD, Vyse TJ, Jacob CO, Pons-Estel B, Argentine Collaborative Group, Niewold TB, Moser Sivils KL, Merrill JT, Anaya JM, Gilkeson GS, Gaffney PM, Bae SC, Alarcon-Riquelme ME, BIOLUPUS and GENLES Networks, Harley JB, Criswell LA, James JA, Nath SK. PTPN22 Association in Systemic Lupus Erythematosus (SLE) with Respect to Individual Ancestry and Clinical Sub-Phenotypes. PLoS One 8:e69404, 2013. [Abstract]

Nocturne G, Boudaoud S, Miceli-Richard C, Viengchareun S, Lazure T, Nititham J, Taylor KE, Ma A, Busato F, Melki J, Lessard CJ, Sivils KL, Dubost JJ, Hachulla E, Gottenberg JE, Lombes M, Tost J, Criswell LA, Mariette X. Germline and somatic genetic variations of TNFAIP3 in lymphoma complicating primary Sjogren’s syndrome. Blood 122:4068-4076, 2013. [Abstract]

Price JV, Haddon DJ, Kemmer D, Delepine G, Mandelbaum G, Jarrell JA, Gupta R, Balboni I, Chakravarty EF, Sokolove J, Shum AK, Anderson MS, Cheng MH, Robinson WH, Browne SK, Holland SM, Baechler EC, Utz PJ. Protein microarray analysis reveals BAFF-binding autoantibodies in systemic lupus erythematosus. J Clin Invest 123:5135-5145, 2013. [Abstract]

* Ramos PS, Oates JC, Kamen DL, Williams AH, Gaffney PM, Kelly JA, Kaufman KM, Kimberly RP, Niewold TB, Jacob CO, Tsao BP, Alarcón GS, Brown EE, Edberg JC, Petri MA, Ramsey-Goldman R, Reveille JD, Vilá LM, James JA, Guthridge JM, Merrill JT, Boackle SA, Freedman BI, Scofield RH, Stevens AM, Vyse TJ, Criswell LA, Moser KL, Alarcón-Riquelme ME, Langefeld CD, Harley JB, Gilkeson GS. Variable Association of Reactive Intermediate Genes with Systemic Lupus Erythematosus in Populations with Different African Ancestry. J Rheumatol 40:842-849, 2013. [Abstract]

Requena T, Gazquez I, Moreno A, Batuecas A, Aran I, Soto-Varela A, Santos-Perez S, Perez N, Perez-Garrigues H, Lopez-Nevot A, Martin E, Sanz R, Perez P, Trinidad G, Alarcón-Riquelme ME, Teggi R, Zagato L, Lopez-Nevot MA, Lopez-Escamez JA. Allelic variants in TLR10 gene may influence bilateral affectation and clinical course of Meniere’s disease. Immunogenetics 65:345-355,2013. [Abstract]

Rider LG, Shah M, Mamyrova G, Huber AM, Rice MM, Targoff IN, Miller FW, for the Childhood Myositis Heterogeneity Collaborative Study Group. The Myositis Autoantibody Phenotypes of the Juvenile Idiopathic Inflammatory Myopathies. Medicine (Baltimore) 92:223-243, 2013. [Abstract]

Rusakiewicz S, Nocturne G, Lazure T, Semeraro M, Flament C, Caillat-Zucman S, Sene D, Delahaye N, Vivier E, Chaba K, Poirier-Colame V, Nordmark G, Eloranta ML, Eriksson P, Theander E, Forsblad-d’Elia H, Omdal R, Wahren-Herlenius M, Jonsson R, Ronnblom L, Nititham J, Taylor KE, Lessard CJ, Sivils KL, Gottenberg JE, Criswell LA, Miceli-Richard C, Zitvogel L, Mariette X. NCR3/NKp30 Contributes to Pathogenesis in Primary Sjogren’s Syndrome. Sci Transl Med 5:195ra96, 2013. [Abstract]

* Sakurai D, Zhao J, Deng Y, Kelly JA, Brown EE, Harley JB, Bae SC, Alarcón-Riquelme ME, on behalf of the BIOLUPUS and GENLES networks, Edberg JC, Kimberly RP, Ramsey-Goldman R, Petri MA, Reveille JD, Vilá LM, Alarcon GS, Kaufman KM, Vyse TJ, Jacob CO, Gaffney PM, Sivils KM, James JA, Kamen DL, Gilkeson GS, Niewold TB, Merrill JT, Scofield RH, Criswell LA, Stevens AM, Boackle SA, Kim JH, Choi J, Pons-Estel BA, on behalf of the Argentine Collaborative Group, Freedman BI, Anaya JM, Martin J, Yu CY, Chang DM, Song YW, Langefeld CD, Chen W, Grossman JM, Cantor RM, Hahn BH, Tsao BP. Preferential Binding to Elk-1 by SLE-Associated Risk Allele Upregulates Expression. PLoS Genet 9:e1003870, 2013. [Abstract]

Saruhan-Direskeneli G, Hughes T, Aksu K, Keser G, Coit P, Aydin SZ, Alibaz-Oner F, Kamali S, Inanc M, Carette S, Hoffman GS, Akar S, Onen F, Akkoc N, Khalidi NA, Koening C, Karadag O, Kiraz S, Langford CA, McAlear CA, Ozbalkan Z, Ates A, Karaaslan Y, Maksimowicz-McKinnon K, Monach PA, Ozer HT, Seyahi E, Fresko I, Cefle A, Seo P, Warrington KJ, Ozturk MA, Ytterberg SR, Cobankara V, Onat AM, Guthridge JM, James JA, Tunc E, Duzgun N, Bicakcigil M, Yentur SP, Merkel PA, Direskeneli H, Sawalha AH. Identification of Multiple Genetic Susceptibility Loci in Takayasu Arteritis. Am J Hum Genet 93:298-305, 2013. [Abstract]

Savitz J, Frank MB, Victor T, Bebak M, Marino JH, Bellgowan PS, McKinney BA, Bodurka J, Kent TT, Drevets WC. Inflammation and neurological disease-related genes are differentially expressed in depressed patients with mood disorders and correlate with morphometric and functional imaging abnormalities. Brain Behav Immun 31:161-171, 2013. [Abstract]

Segal BM, Pogatchnik B, Henn L, Rudser K, Sivils KM. Pain Severity and Neuropathic Pain symptoms in primary Sjogren’s syndrome: A comparison study of seropositive and seronegative Sjogren’s syndrome. Arthritis Care Res (Hoboken) 65:1291-1298, 2013. [Abstract]

Shah D, Sah S, Nath SK. Interaction between glutathione and Apoptosis in Systemic Lupus Erythematosus. Autoimmun Rev 12:741-751,2013. [Abstract]

Shah M, Mamyrova G, Targoff IN, Huber AM, Malley JD, Rice MM, Miller FW, Rider LG, with the Childhood Myositis Heterogeneity Collaborative Study Group. The Clinical Phenotypes of the Juvenile Idiopathic Inflammatory Myopathies. Medicine (Baltimore) 2013:92:25-41. [Abstract]

Shah M, Targoff IN, Rice MM, Miller FW, Rider LG, with the Childhood Myositis Heterogeneity Collaborative Study Group. Ultraviolet radiation exposure is associated with clinical and autoantibody phenotypes in Juvenile Myositis. Arthritis Rheum 65:1934-1941,2013. [Abstract]

Smith K, James JA, Harley JB. Editorial for Lindop et al. “long-term Ro60 humoral autoimmunity in primary Sjogren’s syndrome is maintained by rapid clonal turnover”. Clin Immunol 148:110-112, 2013. [Abstract]

Smith K, Muther JJ, Duke AL, McKee E, Zheng NY, Wilson PC, James JA. Fully human monoclonal antibodies from antibody secreting cells after vaccination with Pneumovax(R)23 are serotype specific and facilitate opsonophagocytosis. Immunobiology 218:745-754, 2013. [Abstract]

St Clair EW, Levesque MC, Prak ET, Vivino FB, Alappatt CJ, Spychala ME, Wedgwood J, McNamara J, Moser Sivils KL, Fisher L, Cohen P, Autoimmunity Centers of Excellence. Rituximab therapy for primary Sjogren’s syndrome: an open-label clinical trial and mechanistic analysis. Arthritis Rheum 65:1097-1106, 2013. [Abstract]

Strickland FM, Hewagama A, Wu A, Sawalha AH, Delaney C, Hoeltzel MF, Yung R, Johnson K, Mickelson B, Richardson BC. Diet influences expression of autoimmune-associated genes and disease severity by epigenetic mechanisms in a transgenic mouse model of lupus. Arthritis Rheum 65:1872-1881, 2013. [Abstract]

Thanou A, Ali T, Haq O, Kaitha S, Morton J, Stavrakis S, Humphrey MB. Utilization of Preventive Measures for Glucocorticoid-Induced Osteoporosis among Veterans with Inflammatory Bowel Disease. ISRN Gastroenterol 2013:862312, 2013. [Abstract]

* Thanou A, Merrill JT. Top 10 things to know about lupus activity measures. Curr Rheumatol Rep 15:334, 2013. [Abstract]

* Towner RA, Jensen RL, Colman H, Vaillant B, Smith N, Casteel R, Saunders D, Gillespie DL, Silasi-Mansat R, Lupu F, Giles CB, Wren JD. ELTD1, A Potential New Biomarker for Gliomas. Neurosurgery 72:77-91, 2013. [Abstract]

* Towner RA, Jensen RL, Vaillant B, Colman H, Saunders D, Giles CB, Wren JD. Experimental validation of 5 in-silico predicted glioma biomarkers. Neuro Oncol 15:1625-1634, 2013. [Abstract]

Trevarton AJ, Mann MB, Knapp C, Araki H, Wren JD, Stones-Havas S, Black MA, Print CG. MelanomaDB: A Web Tool for Integrative Analysis of Melanoma Genomic Information to Identify Disease-Associated Molecular Pathways. Front Oncol 3:184, 2013. [Abstract]

* Wang S, Wen F, Wiley GB, Kinter MT, Gaffney PM. An Enhancer Element Harboring Variants Associated with Systemic Lupus Erythematosus Engages the TNFAIP3 Promoter to Influence A20 Expression. PLoS Genet 9:e1003750, 2013. [Abstract]

Waubant E, Mowry EM, Krupp L, Chitnis T, Yeh EA, Kuntz N, Ness J, Belman A, Milazzo M, Gorman M, Weinstock-Guttman B, Rodriguez M, James JA. Antibody response to common viruses and human leukocyte antigen-DRB1 in pediatric multiple sclerosis. Mult Scler 19:891-895,2013. [Abstract]

Wu YY, Kumar R, Haque MS, Castillejo-Lopez C, Alarcon-Riquelme ME. BANK1 Controls CpG-Induced IL-6 Secretion via a p38 and MNK1/2/eIF4E Translation Initiation Pathway. J Immunol 191:6110-6116,2013. [Abstract]

Cardiovascular Biology Research Program

Ahmed I, Roy B, Chandrakesan P, Venugopal A, Xia L, Jensen R, Anant S, Umar S. Evidence of functional cross talk between the Notch and NF-kappaB pathways in nonneoplastic hyperproliferating colonic epithelium. Am J Physiol Gastrointest Liver Physiol 304:G356-G370, 2013. [Abstract]

Bergstrom KS, Xia L. Mucin-type O-glycans and their roles in intestinal homeostasis. Glycobiology 23:1026-1037,2013. [Abstract]

Davis RB, Curtis CD, Griffin CT. BRG1 promotes COUP-TFII expression and venous specification during embryonic vascular development. Development 140:1272-1281, 2013. [Abstract]

Herzog BH, Fu J, Wilson SJ, Hess PR, Sen A, McDaniel JM, Pan Y, Sheng M, Yago T, Silasi-Mansat R, McGee S, May F, Nieswandt B, Morris AJ, Lupu F, Coughlin SR, McEver RP, Chen H, Kahn ML, Xia L. Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2. Nature 502:105-109,2013. [Abstract]

Huang Q, Qin L, Dai S, Zhang H, Pasula S, Zhou H, Chen H, Min W. AIP1 Suppresses Atherosclerosis by Limiting Hyperlipidemia-Induced Inflammation and Vascular Endothelial Dysfunction. Arterioscler Thromb Vasc Biol 33:795-804, 2013. [Abstract]

Ingram KG, Curtis CD, Silasi-Mansat R, Lupu F, Griffin CT. The NuRD Chromatin-Remodeling Enzyme CHD4 Promotes Embryonic Vascular Integrity by Transcriptionally Regulating Extracellular Matrix Proteolysis. PLoS Genet 9:e1004031, 2013. [Abstract]

Kim YM, Lee JY, Xia L, Mulvihill JJ, Li S. Trisomy 8: a common finding in mouse embryonic stem (ES) cell lines. Mol Cytogenet 6:3, 2013. [Abstract]

Lupu C, Herlea O, Tang H, Lijnen RH, Lupu F. Plasmin-dependent proteolysis of Tissue Factor Pathway Inhibitor in a mouse model of endotoxemia. J Thromb Haemost 11:142-148, 2013.2013. [Abstract]

Qu H, Ricklin D, Bai H, Chen H, Reis ES, Maciejewski M, Tzekou A, Deangelis RA, Resuello RR, Lupu F, Barlow PN, Lambris JD. New analogs of the clinical complement inhibitor compstatin with subnanomolar affinity and enhanced pharmacokinetic properties. Immunobiology 218:496-505,2013. [Abstract]

Song K, Herzog BH, Sheng M, Fu J, McDaniel JM, Ruan J, Xia L. Lenalidomide inhibits lymphangiogenesis in preclinical models of mantle cell lymphoma. Cancer Res 73:7254-7264, 2013. [Abstract]

* Sun D, Popescu NI, Raisley B, Keshari RS, Dale GL, Lupu F, Coggeshall KM. B. anthracis peptidoglycan activates human platelets through FcgammaRII and complement. Blood 122:571-579,2013. [Abstract]

Tappert MM, Porterfield JZ, Mehta-D’Souza P, Gulati S, Air GM. Quantitative comparison of human parainfluenza virus hemagglutinin-neuraminidase receptor binding and receptor cleavage. J Virol 87:8962-8970, 2013. [Abstract]

Tessneer KL, Cai X, Pasula S, Dong Y, Liu X, Chang B, McManus J, Hahn S, Yu L, Chen H. Epsin family of endocytic adaptor proteins as oncogenic regulators of cancer progression. J Cancer Res Updates 2013;2(3):144-50. [Article]

Tessneer KL, Pasula S, Cai X, Dong Y, Liu X, Yu L, Hahn S, McManus J, Chen Y, Chang B, Chen H. Endocytic adaptor protein epsin is elevated in prostate cancer and required for cancer progression. ISRN Oncol 2013:420597, 2013. [Abstract]

Wan X, Sato H, Miyaji H, McDaniel JM, Wang Y, Kaneko E, Gibson B, Mehta JP, Dozmorov M, Miller LP, Goodman J, Sun Z, Xia L. Fucosyltransferase VII improves the function of selectin ligands on cord blood hematopoietic stem cells. Glycobiology 23:1184-1191,2013. [Abstract]

Wang Y, Zhao L, Suzuki A, Lian L, Min SH, Wang Z, Litvinov RI, Stalker TJ, Yago T, Klopocki AG, Schmidtke DW, Yin H, Choi JK, McEver RP, Weisel JW, Hartwig JH, Abrams CS. Platelets lacking PIP5KIgamma have normal integrin activation but impaired cytoskeletal-membrane integrity and adhesion. Blood 121:2743-2752, 2013. [Abstract]

Westmuckett AD, Siefert JC, Tesiram YA, Pinson DM, Moore KL. Salivary Gland Hypofunction in tyrosylprotein sulfotransferase-2 Knockout Mice Is Due to Primary Hypothyroidism. PLoS One 8:e71822, 2013. [Abstract]

Yao L, Heuser-Baker J, Herlea-Pana O, Barlic-Dicen J. Bone marrow endothelial progenitors in atherosclerotic plaque resolution. Organogenesis 9:29-33,2013. [Abstract]

Yao L, Yago T, Shao B, Liu Z, Silasi-Mansat R, Setiadi H, Lupu F, McEver RP. Elevated CXCL1 expression in gp130-deficient endothelial cells impairs neutrophil migration in mice. Blood 122:3832-3842,2013. [Abstract

Zarepour M, Bhullar K, Montero M, Ma C, Huang T, Xia L, Vallance BA. The mucin Muc2 limits pathogen burdens and epithelial barrier dysfunction during Salmonella Typhimurium colitis. Infect Immun 81:3672-3683, 2013. [Abstract]

Zhang Y, Jiang N, Zarnitsyna VI, Klopocki AG, McEver RP, Zhu C. P-selectin glycoprotein ligand-1 forms dimeric interactions with E-selectin but monomeric interactions with L-selectin on cell surfaces. PLoS One 8:e57202, 2013. [Abstract]

Cell Cycle and Cancer Biology Research Program

Earnshaw WC, Allshire RC, Black BE, Bloom K, Brinkley BR, Brown W, Cheeseman IM, Choo KH, Copenhaver GP, Deluca JG, Desai A, Diekmann S, Erhardt S, Fitzgerald-Hayes M, Foltz D, Fukagawa T, Gassmann R, Gerlich DW, Glover DM, Gorbsky GJ, Harrison SC, Heun P, Hirota T, Jansen LE, Karpen G, Kops GJ, Lampson MA, Lens SM, Losada A, Luger K, Maiato H, Maddox PS, Margolis RL, Masumoto H, McAinsh AD, Mellone BG, Meraldi P, Musacchio A, Oegema K, O’Neill RJ, Salmon ED, Scott KC, Straight AF, Stukenberg PT, Sullivan BA, Sullivan KF, Sunkel CE, Swedlow JR, Walczak CE, Warburton PE, Westermann S, Willard HF, Wordeman L, Yanagida M, Yen TJ, Yoda K, Cleveland DW. Esperanto for histones: CENP-A, not CenH3, is the centromeric histone H3 variant. Chromosome Res 21:101-106, 2013. [Abstract]

Gorbsky GJ. Cohesion fatigue. Curr Biol 23:R986-R988, 2013. [Abstract]

Guiraldelli MF, Eyster C, Pezza RJ. Genome instability and embryonic developmental defects in RMI1 deficient mice. DNA Repair (Amst) 12:835-843, 2013. [Abstract]

Guiraldelli MF, Eyster C, Wilkerson JL, Dresser ME, Pezza RJ. Mouse HFM1/Mer3 Is Required for Crossover Formation and Complete Synapsis of Homologous Chromosomes during Meiosis. PLoS Genet 9:e1003383, 2013. [Abstract]

Kim S, Meyer R, Chuong H, Dawson DS. Dual mechanisms prevent premature chromosome segregation during meiosis. Genes Dev 27:2139-2146, 2013. [Abstract]

Lao JP, Cloud V, Huang CC, Grubb J, Thacker D, Lee CY, Dresser ME, Hunter N, Bishop DK. Meiotic crossover control by concerted action of rad51-dmc1 in homolog template bias and robust homeostatic regulation. PLoS Genet 9:e1003978, 2013. [Abstract]

Liu H, Rankin S, Yu H. Phosphorylation-enabled binding of SGO1-PP2A to cohesin protects sororin and centromeric cohesion during mitosis. Nat Cell Biol 15:40-49,2013. [Abstract]

Meyer RE, Dawson DS. Attaching to spindles before they form: Do early incorrect chromosome-microtubule attachments promote meiotic segregation fidelity? Cell Cycle 12:2011-2015, 2013. [Abstract]

Meyer RE, Kim S, Obeso D, Straight PD, Winey M, Dawson DS. Mps1 and Ipl1/Aurora B Act Sequentially to Correctly Orient Chromosomes on the Meiotic Spindle of Budding Yeast. Science 339:1071-1074, 2013. [Abstract]

Ouyang Z, Zheng G, Song J, Borek DM, Otwinowski Z, Brautigam CA, Tomchick DR, Rankin S, Yu H. Structure of the human cohesin inhibitor Wapl. Proc Natl Acad Sci U S A 110:11355-11360, 2013. [Abstract]

Clinical Pharmacology Research Program

Hanly JG, Urowitz MB, O’Keeffe AG, Gordon C, Bae SC, Sanchez-Guerrero J, Romero-Diaz J, Clarke AE, Bernatsky S, Wallace DJ, Ginzler EM, Isenberg DA, Rahman A, Merrill JT, Petri M, Fortin PR, Gladman DD, Fessler BJ, Alarcon GS, Bruce IN, Dooley MA, Steinsson K, Khamashta MA, Ramsey-Goldman R, Manzi S, Sturfelt GK, Nived O, Zoma AA, Van Vollenhoven RF, Ramos-Casals M, Aranow C, Mackay M, Ruiz-Irastorza G, Kalunian KC, Lim SS, Inanc M, Kamen DL, Peschken CA, Jacobsen S, Theriault C, Thompson K, Farewell V. Headache in systemic lupus erythematosus: results from a prospective, international inception cohort study. Arthritis Rheum 65:2887-2897, 2013. [Abstract]

Merrill JT. Co-stimulatory molecules as targets for treatment of lupus. Clin Immunol 148:369-375,2013. [Abstract]

Parker B, Urowitz MB, Gladman DD, Lunt M, Bae SC, Sanchez-Guerrero J, Romero-Diaz J, Gordon C, Wallace DJ, Clarke AE, Bernatsky S, Ginzler EM, Isenberg DA, Rahman A, Merrill JT, Alarcon GS, Fessler BJ, Fortin PR, Hanly JG, Petri M, Steinsson K, Dooley MA, Manzi S, Khamashta MA, Ramsey-Goldman R, Zoma AA, Sturfelt GK, Nived O, Arranow C, Mackay M, Ramos-Casals M, Van Vollenhoven RF, Kalunian KC, Ruiz-Irastorza G, Lim S, Kamen DL, Peschken CA, Inanc M, Bruce IN. Clinical associations of the metabolic syndrome in systemic lupus erythematosus: data from an international inception cohort. Ann Rheum Dis 72:1308-1314,2013. [Abstract]

Peterfy CG, Olech E, Dicarlo JC, Merrill JT, Countryman PJ, Gaylis NB. Monitoring cartilage loss in the hands and wrists in rheumatoid arthritis with magnetic resonance imaging in a multi-center clinical trial: IMPRESS (NCT00425932). Arthritis Res Ther 15:R44, 2013. [Abstract]

Stohl W, Merrill JT, McKay JD, Lisse JR, Zhong ZJ, Freimuth WW, Genovese MC. Efficacy and Safety of Belimumab in Patients with Rheumatoid Arthritis: A Phase II, Randomized, Double-blind, Placebo-controlled, Dose-ranging Study. J Rheumatol 40:579-589, 2013. [Abstract]

* Thanou A, Merrill JT. Top 10 things to know about lupus activity measures. Curr Rheumatol Rep 15:334, 2013. [Abstract]

Zizzo G, Guerrieri J, Dittman LM, Merrill JT, Cohen PL. Circulating levels of soluble MER in lupus reflect M2c activation of monocytes/macrophages, autoantibody specificities and disease activity. Arthritis Res Ther 15:R212, 2013. [Abstract]

Coagulation Biology Laboratory

Alabanza LM, Esmon NL, Esmon CT, Bynoe MS. Inhibition of Endogenous Activated Protein C Attenuates Experimental Autoimmune Encephalomyelitis by Inducing Myeloid-Derived Suppressor Cells. J Immunol 191:3764-3777, 2013. [Abstract]

Bock F, Shahzad K, Wang H, Stoyanov S, Wolter J, Dong W, Pelicci PG, Kashif M, Ranjan S, Schmidt S, Ritzel R, Schwenger V, Reymann KG, Esmon CT, Madhusudhan T, Nawroth PP, Isermann B. Activated protein C ameliorates diabetic nephropathy by epigenetically inhibiting the redox enzyme p66Shc. Proc Natl Acad Sci U S A 110:648-653, 2013. [Abstract]

Borissoff JI, Otten JJ, Heeneman S, Leenders P, van Oerle R., Soehnlein O, Loubele ST, Hamulyak K, Hackeng TM, Daemen MJ, Degen JL, Weiler H, Esmon CT, van Ryn J., Biessen EA, Spronk HM, Ten Cate H. Genetic and Pharmacological Modifications of Thrombin Formation in Apolipoprotein E-deficient Mice Determine Atherosclerosis Severity and Atherothrombosis Onset in a Neutrophil-Dependent Manner. PLoS One 8:e55784, 2013. [Abstract]

Carnemolla R, Greineder CF, Chacko AM, Patel KR, Ding BS, Zaytsev S, Esmon CT, Muzykantov VR. PECAM targeted oxidant-resistant mutant thrombomodulin fusion protein with enhanced potency in vitro and vivo. J Pharmacol Exp Ther 347:339-345, 2013. [Abstract]

Christiaans SC, Wagener BM, Esmon CT, Pittet JF. Protein C and Acute Inflammation: A Clinical and Biologic Perspective. Am J Physiol Lung Cell Mol Physiol 305:L455-L466, 2013. [Abstract]

Esmon CT. Molecular circuits in thrombosis and inflammation. Thromb Haemost 109:416-420, 2013. [Abstract]

Greineder CF, Chacko AM, Zaytsev S, Zern BJ, Carnemolla R, Hood ED, Han J, Ding BS, Esmon CT, Muzykantov VR. Vascular Immunotargeting to Endothelial Determinant ICAM-1 Enables Optimal Partnering of Recombinant scFv-Thrombomodulin Fusion with Endogenous Cofactor. PLoS One 8:e80110, 2013. [Abstract]

Huang H, Chen HW, Evankovich J, Yan W, Rosborough BR, Nace GW, Ding Q, Loughran P, Beer-Stolz D, Billiar TR, Esmon CT, Tsung A. Histones Activate the NLRP3 Inflammasome in Kupffer Cells during Sterile Inflammatory Liver Injury. J Immunol 191:2665-2679, 2013. [Abstract]

Kager LM, Schouten M, Wiersinga WJ, de Boer JD, Lattenist LC, Roelofs JJ, Meijers JC, Levi M, Dondorp AM, Esmon CT, Van’t Veer C, van der Poll T. Overexpression of the Endothelial Protein C Receptor Is Detrimental during Pneumonia-Derived Gram-negative Sepsis (Melioidosis). PLoS Negl Trop Dis 7:e2306, 2013. [Abstract]

Kager LM, Wiersinga WJ, Roelofs JJ, Meijers JC, Zeerleder SS, Esmon CT, Van’t Veer C, van der Poll T. Endogenous protein C has a protective role during gram-negative pneumosepsis (melioidosis). J Thromb Haemost 11:282-292,2013. [Abstract]

Kager LM, Roelofs JJ, de Vos AF, Wieland CW, Schouten M, Meijers JC, Isermann B, Van’t Veer C, Esmon CT, van der Poll T. The endothelial protein C receptor and activated protein C play a limited role in host defense during experimental tuberculosis. Thromb Haemost 109: 726-737,2013. [Abstract]

Moxon CA, Wassmer SC, Milner DA, Jr., Chisala NV, Taylor TE, Seydel KB, Molyneux ME, Faragher B, Esmon CT, Downey C, Toh CH, Craig AG, Heyderman RS. Loss of endothelial protein C receptors links coagulation and inflammation to parasite sequestration in cerebral malaria in African children. Blood 122:842-851, 2013. [Abstract]

Nayak RC, Keshava S, Esmon CT, Pendurthi UR, Rao LV. Rab GTPases Regulate Endothelial Cell Protein C Receptor-Mediated Endocytosis and Trafficking of Factor VIIa. PLoS One 8:e59304, 2013. [Abstract]

Schaffner F, Yokota N, Carneiro-Lobo T, Kitano M, Schaffer M, Anderson GM, Mueller BM, Esmon CT, Ruf W. Endothelial Protein C Receptor Function in Murine and Human Breast Cancer Development. PLoS One 8:e61071, 2013. [Abstract]

Vadivel K, Agah S, Messer AS, Cascio D, Bajaj MS, Krishnaswamy S, Esmon CT, Padmanabhan K, Bajaj SP. Structural and Functional Studies of gamma-Carboxyglutamic Acid Domains of Factor VIIa and Activated Protein C: Role of Magnesium at Physiological Calcium. J Mol Biol 425:1961-1981,2013. [Abstract]

Vincent JL, Ramesh MK, Ernest D, Larosa SP, Pachl J, Aikawa N, Hoste E, Levy H, Hirman J, Levi M, Daga M, Kutsogiannis DJ, Crowther M, Bernard GR, Devriendt J, Puigserver JV, Blanzaco DU, Esmon CT, Parrillo JE, Guzzi L, Henderson SJ, Pothirat C, Mehta P, Fareed J, Talwar D, Tsuruta K, Gorelick KJ, Osawa Y, Kaul I. A Randomized, Double-Blind, Placebo-Controlled, Phase 2b Study to Evaluate the Safety and Efficacy of Recombinant Human Soluble Thrombomodulin, ART-123, in Patients With Sepsis and Suspected Disseminated Intravascular Coagulation*. Crit Care Med 41:2069-2079, 2013. [Abstract]

Experimental Therapeutics

Du X, Ewert DL, Cheng W, West MB, Lu J, Li W, Floyd RA, Kopke RD. Effects of antioxidant treatment on blast-induced brain injury. PLoS One 8:e80138, 2013. [Abstract]

*Floyd RA, Castro Faria Neto HC, Zimmerman GA, Hensley K, Towner RA. Nitrone-based therapeutics for neurodegenerative diseases: their use alone or in combination with lanthionines. Free Radic Biol Med 62:145-156, 2013. [Abstract]

*Towner RA, Gillespie DL, Schwager A, Saunders DG, Smith N, Njoku CE, Krysiak RS, III, Larabee C, Iqbal H, Floyd RA, Bourne DW, Abdullah O, Hsu EW, Jensen RL. Regression of glioma tumor growth in F98 and U87 rat glioma models by the Nitrone OKN-007. Neuro Oncol 15:330-340, 2013. [Abstract]

Zheng X, Gai X, Han S, Moser CD, Hu C, Shire AM, Floyd RA, Roberts LR. The human sulfatase 2 inhibitor 2,4-disulfonylphenyl-tert-butylnitrone (OKN-007) has an antitumor effect in hepatocellular carcinoma mediated via suppression of TGFB1/SMAD2 and Hedgehog/GLI1 signaling. Genes Chromosomes Cancer 52:225-236, 2013. [Abstract]

Free Radical Biology and Aging Research Program

Allen BG, Bhatia SK, Buatti JM, Brandt KE, Lindholm KE, Button AM, Szweda LI, Smith B, Spitz DR, Fath MA. Ketogenic Diets Enhance Oxidative Stress and Radio-Chemo-Therapy Responses in Lung Cancer Xenografts. Clin Cancer Res 19:3905-3913, 2013. [Abstract]

Bhatnagar A, Unal H, Jagannathan R, Kaveti S, Duan ZH, Yong S, Vasanji A, Kinter M, Desnoyer R, Karnik SS. Interaction of G-Protein betagamma Complex with Chromatin Modulates GPCR-Dependent Gene Regulation. PLoS One 8:e52689, 2013. [Abstract]

Crewe C, Kinter M, Szweda LI. Rapid Inhibition of Pyruvate Dehydrogenase: An Initiating Event in High Dietary Fat-Induced Loss of Metabolic Flexibility in the Heart. PLoS One 8:e77280, 2013. [Abstract]

Ghosh S, Willard B, Comhair S, Dibello P, Xu W, Shiva S, Aulak KS, Kinter M, Erzurum SC. Disulfide bond as a switch for copper-zinc superoxide dismutase activity in asthma. Antioxid Redox Signal 18:412-423, 2013. [Abstract]

Hallgren KW, Zhang D, Kinter M, Willard B, Berkner KL. Methylation of gamma-carboxylated Glu (Gla) allows detection by liquid chromatography-mass spectrometry and the identification of Gla residues in the gamma-glutamyl carboxylase. J Proteome Res 12:2365-2374, 2013. [Abstract]

Hardas SS, Sultana R, Clark AM, Beckett TL, Szweda LI, Murphy MP, Butterfield DA. Oxidative modification of lipoic acid by HNE in Alzheimer disease brain. Redox Biol 1:80-85, 2013. [Abstract]

Macdonald MJ, Langberg EC, Tibell A, Sabat G, Kendrick MA, Szweda LI, Ostenson CG. Identification of ATP Synthase As a Lipid Peroxide Protein Adduct in Pancreatic Islets From Humans With and Without Type 2 Diabetes Mellitus. J Clin Endocrinol Metab 98:E727-E731, 2013. [Abstract]

McLain AL, Cormier PJ, Kinter M, Szweda LI. Glutathionylation of alpha-Ketoglutarate Dehydrogenase: The Chemical Nature and Relative Susceptibility of the Cofactor Lipoic Acid to Modification. Free Radic Biol Med 61C:161-169, 2013. [Abstract]

O’Conor CJ, Griffin TM, Liedtke W, Guilak F. Increased susceptibility of Trpv4-deficient mice to obesity and obesity-induced osteoarthritis with very high-fat diet. Ann Rheum Dis 72:300-304, 2013. [Abstract]

Perry EA, Castellani RJ, Moreira PI, Nunomura AA, Liu Q, Harris PL, Sayre LM, Szweda PA, Szweda LI, Zhu X, Smith MA, Perry G. Neurofilaments are the Major Neuronal Target of Hydroxynonenal Mediated Protein Crosslinks. Free Radic Res 47:507-510, 2013. [Abstract]

Rindler PM, Crewe CL, Fernandes J, Kinter M, Szweda LI. Redox Regulation of Insulin Sensitivity due to Enhanced Fatty Acid Utilization in the Mitochondria. Am J Physiol Heart Circ Physiol 305:H634-H643, 2013. [Abstract]

Rindler PM, Plafker SM, Szweda LI, Kinter M. High dietary fat selectively increases catalase expression within cardiac mitochondria. J Biol Chem 288:1979-1990,2013. [Abstract]

Thiagarajan PS, Akbasli AC, Kinter MT, Willard B, Cathcart MK. Vimentin is a target of PKCbeta phosphorylation in MCP-1-activated primary human monocytes. Inflamm Res 62:991-1001, 2013. [Abstract]

Vadvalkar SS, Baily CN, Matsuzaki S, West M, Tesiram YA, Humphries KM. Metabolic inflexibility and protein lysine acetylation in heart mitochondria of a chronic model of Type 1 diabetes. Biochem J 449:253-261, 2013. [Abstract]

Genetic Models of Disease Research Program

Edwards SL, Yu SC, Hoover CM, Phillips BC, Richmond JE, Miller KG. An Organelle Gatekeeper Function for Caenorhabditis elegans UNC-16 (JIP3) at the Axon Initial Segment. Genetics 194:143-161, 2013. [Abstract]

Immunobiology and Cancer Research Program

An JH, Kurokawa K, Jung DJ, Kim MJ, Kim CH, Fujimoto Y, Fukase K, Coggeshall KM, Lee BL. Human SAP Is a Novel Peptidoglycan Recognition Protein That Induces Complement-Independent Phagocytosis of Staphylococcus aureus. J Immunol 191:3319-3327, 2013. [Abstract]

Barua S, Iyer JK, Larabee JL, Raisley B, Hughes MA, Coggeshall KM, Ballard JD. Toxin Inhibition of Antimicrobial Factors Induced by Bacillus anthracis Peptidoglycan in Human Blood. Infect Immun 81:3693-3702,2013. [Abstract]

Iwayama T, Olson LE. Involvement of PDGF in Fibrosis and Scleroderma: Recent Insights from Animal Models and Potential Therapeutic Opportunities. Curr Rheumatol Rep 15:304, 2013. [Abstract]

Liu C, Jin R, Wang HC, Tang H, Liu YF, Qian XP, Sun XY, Ge Q, Sun XH, Zhang Y. Id1 expression promotes peripheral CD4 T cell proliferation and survival upon TCR activation without co-stimulation. Biochem Biophys Res Commun 436:47-52, 2013. [Abstract]

Satoh Y, Yokota T, Sudo T, Kondo M, Lai A, Kincade PW, Kouro T, Iida R, Kokame K, Miyata T, Habuchi Y, Matsui K, Tanaka H, Matsumura I, Oritani K, Kohwi-Shigematsu T, Kanakura Y. The Satb1 Protein Directs Hematopoietic Stem Cell Differentiation toward Lymphoid Lineages. Immunity 38:1105-1115,2013. [Abstract]

Shen W, Tremblay MS, Deshmukh VA, Wang W, Filippi CM, Harb G, Zhang YQ, Kamireddy A, Baaten JE, Jin Q, Wu T, Swoboda JG, Cho CY, Li J, Laffitte BA, McNamara P, Glynne R, Wu X, Herman AE, Schultz PG. Small-Molecule Inducer of beta Cell Proliferation Identified by High-Throughput Screening. J Am Chem Soc 135:1669-1672, 2013. [Abstract]

* Sun D, Popescu NI, Raisley B, Keshari RS, Dale GL, Lupu F, Coggeshall KM. B. anthracis peptidoglycan activates human platelets through FcgammaRII and complement. Blood 122:571-579,2013. [Abstract]

Thompson LF. Editorial: CD73 deficiency and immune dysregulation in HIV infection: cause or effect? J Leukoc Biol 94:545-547, 2013. [Abstract]

Thompson LF, Tsukamoto H, Chernogorova P, Zeiser R. A delicate balance: CD73-generated adenosine limits the severity of graft vs. host disease but also constrains the allogeneic graft vs. tumor effect. Oncoimmunology 2:e22107, 2013. [Abstract]

Zhang P, Zhao Y, Sun XH. Notch-Regulated Periphery B Cell Differentiation Involves Suppression of E Protein Function. J Immunol 191:726-736, 2013. [Abstract]

Zhang Q, Esplin BL, Iida R, Garrett KP, Huang ZL, Medina KL, Kincade PW. RAG-1 and Ly6D Independently Reflect Progression in the B Lymphoid Lineage. PLoS One 8:e72397, 2013. [Abstract]

Zhang Q, Iida R, Yokota T, Kincade PW. Early events in lymphopoiesis: an update. Curr Opin Hematol 20:265-272, 2013. [Abstract]

Zhao Y, Ling F, Wang HC, Sun XH. Chronic TLR Signaling Impairs the Long-Term Repopulating Potential of Hematopoietic Stem Cells of Wild Type but Not Id1 Deficient Mice. PLoS One 8:e55552, 2013. [Abstract]

Lipid Studies

Azar M, Lyons TJ, Alaupovic P, Stoner JA, Quiroga C, Kaufman DG, Lopes-Virella M, Klein RL, Jenkins AJ, VADT Study Group. Apolipoprotein-defined and NMR lipoprotein subclasses in the veterans affairs diabetes trial. J Diabetes Complications 27:627-632, 2013. [Abstract]

Blackett P, Tryggestad J, Krishnan S, Li S, Xu W, Alaupovic P, Quiroga C, Copeland K. Lipoprotein abnormalities in compound heterozygous lipoprotein lipase deficiency after treatment with a low-fat diet and orlistat. J Clin Lipidol 7:132-139, 2013. [Abstract]

Gardner AW, Alaupovic P, Parker DE, Montgomery PS, Roof A, Casanegra AI. Apolipoprotein profiles in subjects with and without peripheral artery disease. Vasc Med 18:129-135, 2013. [Abstract]

Gardner AW, Alaupovic P, Parker DE, Montgomery PS, Esponda OL, Casanegra AI. Influence of Peripheral Artery Disease and Statin Therapy on Apolipoprotein Profiles. Int J Vasc Med 2013:548764, 2013. [Abstract]

Jenkins AJ, Yu J, Alaupovic P, Basu A, Klein RL, Lopes-Virella M, Baker NL, Hunt KJ, Lackland DT, Garvey WT, Lyons TJ, DCCT/EDIC Research Group. Apolipoprotein-defined lipoproteins and apolipoproteins: Associations with abnormal albuminuria in type 1 diabetes in the diabetes control and complications trial/epidemiology of diabetes interventions and complications cohort. J Diabetes Complications 27:447-453, 2013. [Abstract]

Kwiterovich PO, Virgil DG, Chu AY, Khouzami VA, Alaupovic P, Otvos JD. Interrelationships between the concentration and size of the largest high-density lipoprotein subfraction and apolipoprotein C-I in infants at birth and follow-up at 2-3 months of age and their parents. J Clin Lipidol 7:29-37, 2013. [Abstract]

McNeal CJ, Chatterjee S, Hou J, Worthy LS, Larner CD, Macfarlane RD, Alaupovic P, Brocia RW. Human HDL containing a novel apoC-I isoform induces smooth muscle cell apoptosis. Cardiovasc Res 98:83-93, 2013. [Abstract]

Samuelsson O, Attman PO, Gause-Nilsson I, Svensson MK, Alaupovic P. Dual PPAR alpha / gamma Agonism Normalizes Lipoprotein Profile of Renal Dyslipidemia. PPAR Res 2013:391628, 2013. [Abstract]

Wang W, Khan S, Blackett P, Alaupovic P, Lee E. Apolipoproteins A-I, B, and C-III in young adult Cherokee with metabolic syndrome with or without type 2 diabetes. J Clin Lipidol 7:38-42, 2013. [Abstract]

Protein Studies Research Program

Coughlan K, Huang X, He X, Chung CH, Li G, Tang J. Expression and processing of fluorescent fusion proteins of amyloid precursor protein (APP). Biochim Biophys Acta 1833:1562-1571, 2013. [Abstract]

Li X, Hong L, Coughlan K, Wang L, Cao L, Tang J. Structure-activity relationship of memapsin 2: implications on physiological functions and Alzheimer’s disease. Acta Biochim Biophys Sin (Shanghai) 45:613-621, 2013. [Abstract]

Wu H, Downs D, Ghosh K, Ghosh AK, Staib P, Monod M, Tang J, Puatanachokchai R. Candida albicans secreted aspartic proteases 4-6 induce apoptosis of epithelial cells by a novel Trojan horse mechanism. FASEB J 27:2132-2144, 2013. [Abstract]

* Indicates publications by more than one department or group.

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