2010 Scientific Publications

Advanced Magnetic Resonance Center

Awasthi V, Agashe H, Doblas S, Towner R. Magnetic resonance spectroscopy for evaluation of liposome-encapsulated hemoglobin as a resuscitation fluid. Artif Cells Blood Substit Immobil Biotechnol 38:69-78, 2010. Abstract

Bozza FA, Garteiser P, Oliveira MF, Doblas S, Cranford R, Saunders D, Jones I, Towner RA, Castro-Faria-Neto HC. Sepsis-associated encephalopathy: a magnetic resonance imaging and spectroscopy study. J Cereb Blood Flow Metab 30:440-449, 2010. Abstract

Doblas S, He T, Saunders D, Pearson J, Hoyle J, Smith N, Lerner M, Towner RA. Glioma morphology and tumor-induced vascular alterations revealed in seven rodent glioma models by in vivo magnetic resonance imaging and angiography. J Magn Reson Imaging 32:267-275, 2010. Abstract

* Floyd RA, Towner RA, Wu D, Abbott A, Cranford R, Branch D, Guo WX, Foster SB, Jones I, Alam R, Moore D, Allen T, Huycke M. Anti-cancer activity of nitrones in the Apc(Min/+) model of colorectal cancer. Free Radic Res 44:108-117, 2010. Abstract

* Garteiser P, Doblas S, Watanabe Y, Saunders D, Hoyle J, Lerner M, He T, Floyd RA, Towner RA. Multiparametric assessment of the anti-glioma properties of OKN007 by magnetic resonance imaging. J Magn Reson Imaging 31:796-806, 2010. Abstract

Griffitts J, Saunders D, Tesiram YA, Reid GE, Salih A, Liu S, Lydic TA, Busik JV, Kang JX, Towner RA. Non-mammalian fat-1 gene prevents neoplasia when introduced to a mouse hepatocarcinogenesis model Omega-3 fatty acids prevent liver neoplasia. Biochim Biophys Acta 1801:1133-1144, 2010. Abstract

Johnson AC, Myers B, Lazovic J, Towner R, Greenwood-Van MB. Brain activation in response to visceral stimulation in rats with amygdala implants of corticosterone: an FMRI study. PLoS ONE 5:e8573, 2010. Abstract

Qiu P, Jensen C, Charity N, Towner R, Mao C. Oil phase evaporation-induced self-assembly of hydrophobic nanoparticles into spherical clusters with controlled surface chemistry in an oil-in-water dispersion and comparison of behaviors of individual and clustered iron oxide nanoparticles. J Am Chem Soc 132:17724-17732, 2010. Abstract

Tesiram YA. Implementation equations for HS_n RF pulses. J Magn Reson 204:333-339, 2010. Abstract

* Towner RA, Smith N, Asano Y, Doblas S, Saunders D, Silasi-Mansat R, Lupu F. Molecular magnetic resonance imaging approaches used to aid in the understanding of the tissue regeneration marker Met in vivo: implications for tissue engineering. Tissue Eng Part A 16:365-371, 2010.Abstract

* Towner RA, Smith N, Asano Y, He T, Doblas S, Saunders D, Silasi-Mansat R, Lupu F, Seeney CE. Molecular magnetic resonance imaging approaches used to aid in the understanding of angiogenesis in vivo: implications for tissue engineering. Tissue Eng Part A 16:357-364, 2010. Abstract

* Towner RA, Smith N, Doblas S, Garteiser P, Watanabe Y, He T, Saunders D, Herlea O, Silasi-Mansat R, Lupu F. In vivo detection of inducible nitric oxide xynthase (iNOS) in rodent gliomas. Free Radic Biol Med 48:691-703, 2010. Abstract

Arthritis and Clinical Immunology Research Program

Aggarwal R, Namjou B, Li S, D’Souza A, Tsao BP, Bruner BF, James JA, Scofield RH. Male-only systemic lupus. J Rheumatol 37:1480-1487, 2010. Abstract

Aggarwal R, Sestak AL, D’Sousa A, Dillon SP, Namjou B, Scofield R. Complete complement deficiency in a large cohort of familial systemic lupus erythematosus. Lupus 19:52-57, 2010. Abstract

Alex P, Ye M, Zachos NC, Sipes J, Nguyen T, Suhodrev M, Gonzales L, Arora Z, Zhang T, Centola M, Guggino SE, Li X. Clcn5 knockout mice exhibit novel immunomodulatory effects and are more susceptible to dextran sulfate sodium-induced colitis. J Immunol 184:3988-3996, 2010. Abstract

Al-Ali FM, Ratnamala U, Mehta TY, Naveed M, Al-Ali MT, Al-Khaja N, Sheth JJ, Master DC, Maiti AK, Chetan GK, Nath SK, Radhakrishna U. Hidradenitis suppurativa (or Acne inversa) with autosomal dominant inheritance is not linked to chromosome 1p21.1-1q25.3 region. Exp Dermatol 19:851-853, 2010. Abstract

Been LF, Nath SK, Ralhan SK, Wander GS, Mehra NK, Singh J, Mulvihill JJ, Sanghera DK. Replication of association between a common variant near melanocortin-4 receptor gene and obesity-related traits in Asian Sikhs. Obesity (Silver Spring) 18:425-429, 2010. Abstract

Bronson PG, Komorowski LK, Ramsay PP, May SL, Noble J, Lane JA, Thomson G, Claas FH, Seldin MF, Kelly JA, Harley JB, Moser KL, Gaffney PM, Behrens T, Criswell LA, Barcellos LF. Analysis of maternal-offspring HLA compatibility, parent-of-origin effects, and noninherited maternal antigen effects for HLA-DRB1 in systemic lupus erythematosus. Arthritis Rheum 62:1712-1717, 2010. Abstract

Bruner BF, Vista ES, Wynn DM, Harley JB, James JA. Anti-neutrophil cytoplasmic antibodies target sequential functional proteinase 3 epitopes in the sera of patients with Wegener’s granulomatosis. Clin Exp Immunol 162:262-270, 2010. Abstract

* Carreras E, Turner S, Frank MB, Knowlton N, Osban J, Centola M, Park CG, Simmons A, Alberola-Ila J, Kovats S. Estrogen receptor signaling promotes dendritic cell differentiation by increasing expression of the transcription factor IRF4. Blood 115:238-246, 2010. Abstract

Carroll M, James JA, Lardiere MR, Proser M, Rhee K, Sayre MH, Shore JH, Ternullo J. Innovation networks for improving access and quality across the healthcare ecosystem. Telemed J E Health 16:107-111, 2010. Abstract

Charles E, Joshi S, Ash JD, Fox BA, Farris AD, Bzik DJ, Lang ML, Blader IJ. CD4 T-cell suppression by cells from Toxoplasma gondii-infected retinas is mediated by surface protein PD-L1. Infect Immun 78:3484-3492, 2010. Abstract

Clancy RM, Marion MC, Kaufman KM, Ramos PS, Adler A, International Consortium on Systemic Lupus Erythematosus Genetics, Harley JB, Langefeld CD, Buyon JP. Identification of candidate loci at 6p21 and 21q22 in a genome-wide association study of cardiac manifestations of neonatal lupus. Arthritis Rheum 62:3415-3424, 2010. Abstract

Cobb BL, Fei Y, Jonsson R, Bolstad AI, Brun JG, Rischmueller M, Lester SE, Witte T, Illei G, Brennan M, Bowman S, Moser KL, Harley JB, Sawalha AH. Genetic association between methyl-CpG binding protein 2 (MECP2) and primary Sjogren’s syndrome. Ann Rheum Dis 69:1731-1732, 2010. Abstract

Crowe SR, Ash LL, Engler RJ, Ballard JD, Harley JB, Farris AD, James JA. Select human anthrax protective antigen epitope-specific antibodies provide protection from lethal toxin challenge. J Infect Dis 202:251-260, 2010. Abstract

Delgado-Vega AM, Alarcon-Riquelme ME, Kozyrev SV. Genetic associations in type I interferon related pathways with autoimmunity. Arthritis Res Ther 12 Suppl 1:S2, 2010. Abstract

Delgado-Vega A, Sánchez E, Löfgren S, Castillejo-López C, Alarcón-Riquelme ME. Recent findings on genetics of systemic autoimmune diseases. Curr Opin Immunol 22:698-705, 2010. Abstract

* Dias-Baruffi M, Stowell SR, Song SC, Arthur CM, Cho M, Rodrigues LC, Montes MA, Rossi MA, James JA, McEver RP, Cummings RD. Differential expression of immunomodulatory galectin-1 in peripheral leukocytes and adult tissues and its cytosolic organization in striated muscle. Glycobiology 20:507-520, 2010. Abstract

Dorri Y, Kurien BT. Environmentally safe removal/disposal of Coomassie Brilliant Blue from gel destain and used gel stain. Anal Biochem 404:193-196, 2010. Abstract

Dozmorov MG, Azzarello JT, Wren JD, Fung KM, Yang Q, Davis JS, Hurst RE, Culkin DJ, Penning TM, Lin HK. Elevated AKR1C3 expression promotes prostate cancer cell survival and prostate cell-mediated endothelial cell tube formation: Implications for prostate cancer progression. BMC Cancer 10:672, 2010. Abstract

Dozmorov IM, Dresser D. Immune System as a Sensory System. Int J Biomed Sci 6:167-175, 2010. Abstract

Dozmorov MG, Guthridge JM, Hurst RE, Dozmorov IM. A comprehensive and universal method for assessing the performance of differential gene expression analyses. PLoS ONE 5:2010. Abstract

Errami M, Sun Z, George AC, Long TC, Skinner MA, Wren JD, Garner HR. Identifying duplicate content using statistically improbable phrases. Bioinformatics 26:1453-1457, 2010. Abstract

Fesmire J, Wolfson-Reichlin M, Reichlin M. [Effects of autoimmune antibodies anti-lipoprotein lipase, anti-low density lipoprotein, and anti-oxidized low density lipoprotein on lipid metabolism and atherosclerosis in systemic lupus erythematosus.]. Rev Bras Reumatol 50:539-551, 2010. Abstract

Fredi M, Tincani A, Yin H, Delgado-Vega AM, Borghi MO, Meroni PL, Alarcón-Riquelme ME. IRF5 is associated with primary antiphospholipid syndrome but it’s not a major factor risk. Arthritis Rheum 62:1201-1202, 2010. Abstract

Fürnrohr BG, Wach S, Kelly JA, Haslbeck M, Weber CK, Stach CM, Hueber AJ, Graef D, Spriewald BM, Manger K, Herrmann M, Kaufman KM, Frank SG, Goodmon E, James JA, Schett G, Winkler TH, Harley JB, Voll RE. Polymorphisms in the Hsp70 gene locus are genetically associated with systemic lupus erythematosus. Ann Rheum Dis 69:1983-1989, 2010. Abstract

Galarza-Maldonado C, Kourilovitch MR, Molineros JE, Cardiel MH, Zurita L, Soroka NF, Yagur VY, Doukh N, Cervera R. The administration of low doses of rituximab followed by hydroxychloroquine, prednisone and low doses of mycophenolate mofetil is an effective therapy in Latin American patients with active systemic lupus erythematosus. Autoimmun Rev 10:108-111, 2010. Abstract

Gray-McGuire C, Guda K, Adrianto I, Lin CP, Natale L, Potter JD, Newcomb P, Poole EM, Ulrich CM, Lindor N, Goode EL, Fridley BL, Jenkins R, Le ML, Casey G, Haile R, Hopper J, Jenkins M, Young J, Buchanan D, Gallinger S, Adams M, Lewis S, Willis J, Elston R, Markowitz SD, Wiesner GL. Confirmation of linkage to and localization of familial colon cancer risk haplotype on chromosome 9q22. Cancer Res 70:5409-5418, 2010. Abstract

* Harley IT, Niewold TB, Stormont RM, Kaufman KM, Glenn SB, Franek BS, Kelly JA, Kilpatrick JR, Hutchings D, Divers J, Bruner GR, Edberg JC, McGwin G, Jr., Petri MA, Ramsey-Goldman R, Reveille JD, Vila-Perez LM, Merrill JT, Gilkeson GS, Vyse TJ, Alarcon-Riquelme ME, Cho SK, Jacob CO, Alarcon GS, Moser KL, Gaffney PM, Kimberly RP, Bae SC, Langefeld CD, Harley JB, Guthridge JM, James JA. The role of genetic variation near interferon-kappa in systemic lupus erythematosus. J Biomed Biotechnol 2010:Article 706825 [11 pages], 2010. Abstract

Harley JB, James JA. Everyone comes from somewhere: systemic lupus erythematosus and Epstein-Barr virus induction of host interferon and humoral anti-Epstein-Barr nuclear antigen 1 immunity. Arthritis Rheum 62:1571-1575, 2010. Abstract

Heinlen LD, McClain MT, Ritterhouse LL, Bruner BF, Edgerton CC, Keith MP, James JA, Harley JB. 60 kD Ro and nRNP A frequently initiate human lupus autoimmunity. PLoS ONE 5:e9599, 2010. Abstract

Heinlen LD, Ritterhouse LL, McClain MT, Keith MP, Neas BR, Harley JB, James JA. Ribosomal P autoantibodies are present before SLE onset and are directed against non-C-terminal peptides. J Mol Med 88:719-727, 2010. Abstract

Hoemann CD, Chen G, Marchand C, Tran-Khanh N, Thibault M, Chevrier A, Sun J, Shive MS, Fernandes MJ, Poubelle PE, Centola M, El-Gabalawy H. Scaffold-guided subchondral bone repair: implication of neutrophils and alternatively activated arginase-1+ macrophages. Am J Sports Med 38:1845-1856, 2010. Abstract

Horton CG, Pan ZJ, Farris AD. Targeting Toll-like receptors for treatment of SLE. Mediators Inflamm 2010:498980, 2010. Abstract

Hughes T, Webb R, Fei Y, Wren JD, Sawalha AH. DNA methylome in human CD4+ T cells identifies transcriptionally repressive and non-repressive methylation peaks. Genes Immun 11:554-560, 2010. Abstract

Jarvis JN, Frank MB. Functional genomics and rheumatoid arthritis: where have we been and where should we go? Genome Med 2:44, 2010. Abstract

Javierre BM, Fernandez AF, Richter J, Al-Shahrour F, Martin-Subero JI, Rodriguez-Ubreva J, Berdasco M, Fraga MF, O’Hanlon TP, Rider LG, Jacinto FV, Lopez-Longo FJ, Dopazo J, Forn M, Peinado MA, Carreno L, Sawalha AH, Harley JB, Siebert R, Esteller M, Miller FW, Ballestar E. Changes in the pattern of DNA methylation associate with twin discordance in systemic lupus erythematosus. Genome Res 20:170-179, 2010. Abstract

Kim K, Cho SK, Sestak A, Namjou B, Kang C, Bae SC. Interferon-gamma gene polymorphisms associated with susceptibility to systemic lupus erythematosus. Ann Rheum Dis 69:1247-1250, 2010. Abstract

* Kim-Howard X, Maiti AK, Anaya JM, Bruner GR, Brown E, Merrill JT, Edberg JC, Petri MA, Reveille JD, Ramsey-Goldman R, Alarcón GS, Vyse TJ, Gilkeson G, Kimberly RP, James JA, Guthridge JM, Harley JB, Nath SK. ITGAM coding variant (rs1143679) influences the risk of renal disease, discoid rash, and immunologic manifestations in patients with systemic lupus erythematosus with European ancestry. Ann Rheum Dis 69:1329-1332, 2010. Abstract

Kivity S, Tsarfaty G, Agmon-Levin N, Blank M, Manor D, Konen E, Chapman J, Reichlin M, Wasson C, Shoenfeld Y, Kushnir T. Abnormal olfactory function demonstrated by manganese-enhanced MRI in mice with experimental neuropsychiatric lupus. Ann N Y Acad Sci 1193:70-77, 2010. Abstract

Kristjansdottir H, Steinsson K, Gunnarsson I, Gröndal G, Erlendsson K, Alarcón-Riquelme ME. Lower expression levels of the programmed death 1 receptor on CD4+CD25+ T-cells in SLE patients and correlation to the PD-1.3A genotype. Arthritis Rheum 62:1702-1711, 2010. Abstract

Kurien BT, D’Souza A, Scofield RH. Heat-solubilized curry spice curcumin inhibits antibody-antigen interaction in in vitro studies: A possible therapy to alleviate autoimmune disorders. Mol Nutr Food Res 54:1202-1209, 2010. Abstract

Larkin EK, Patel SR, Goodloe RJ, Li Y, Zhu X, Gray-McGuire C, Adams MD, Redline S. A Candidate gene study of obstructive sleep apnea in European Americans and African Americans. Am J Respir Crit Care Med 182:947-953, 2010. Abstract

Lee YJ, Scofield RH, Hyon JY, Yun PY, Lee HJ, Lee EY, Lee EB, Song YW. Salivary chemokine levels in patients with primary Sjogren’s syndrome. Rheumatology (Oxford) 49:1747-1752, 2010. Abstract

Lofgren SE, Delgado-Vega AM, Gallant CJ, Sanchez E, Frostegard J, Truedsson L, Garrido ED, Sabio JM, Gonzalez-Escribano MF, Pons-Estel BA, D’Alfonso S, Witte T, Lauwerys BR, Endreffy E, Kovacs L, Vasconcelos C, da Silva BM, Martin J, Alarcon-Riquelme ME, Kozyrev SV. A 3′-untranslated region variant is associated with impaired expression of CD226 in T and natural killer T cells and is associated with susceptibility to systemic lupus erythematosus. Arthritis Rheum 62:3404-3414, 2010. Abstract

Lofgren S, Yin H, Delgado-Vega AM, Sanchez E, Lewen S, Pons-Estel BA, Witte T, D’Alfonso S, Ortego-Centeno N, Martin J, Alarcón-Riquelme ME, Kozyrev SV. Promoter insertion/deletion in the IRF5 gene is highly associated with susceptibility to systemic lupus erythematosus in distinct populations, but exerts a modest effect on gene expression in peripheral blood mononuclear cells. J Rheumatol 37:574-578, 2010. Abstract

Lu LJ, Wallace DJ, Ishimori ML, Scofield RH, Weisman MH. Male systemic lupus erythematosus: a review of sex disparities in this disease. Lupus 19:119-129, 2010. Abstract

Maiti AK. Gene network analysis of oxidative stress-mediated drug sensitivity in resistant ovarian carcinoma cells. Pharmacogenomics J 10:94-104, 2010. Abstract

Maiti AK, Kim-Howard X, Viswanathan P, Guillen L, Rojas-Villarraga A, Deshmukh H, Direskeneli H, Saruhan-Direskeneli G, Canas C, Tobon GJ, Sawalha AH, Chernavsky AC, Anaya JM, Nath SK. Confirmation of an association between rs6822844 at the Il2-Il21 region and multiple autoimmune diseases: Evidence of a general susceptibility locus. Arthritis Rheum 62:323-329, 2010. Abstract

Maiti AK, Kim-Howard X, Viswanathan P, Guillén L, Qian X, Rojas-Villarraga A, Sun C, Cañas C, Tobón GJ, Matsuda K, Shen N, Cherñavsky AC, Anaya JM, Nath SK. Non-synonymous variant (Gly307Ser) in CD226 is associated with susceptibility to multiple autoimmune diseases. Rheumatology (Oxford) 49:1239-1244, 2010. Abstract

Nakou M, Bertsias G, Stagakis I, Centola M, Tassiulas I, Hatziapostolou M, Kritikos I, Goulielmos G, Boumpas DT, Iliopoulos D. Gene network analysis of bone marrow mononuclear cells reveals activation of multiple kinase pathways in human systemic lupus erythematosus. PLoS ONE 5:e13351, 2010. Abstract

Ojwang JO, Adrianto I, Gray-McGuire C, Nath SK, Sun C, Kaufman KM, Harley JB, Rayan GM. Genome-wide association scan of Dupuytren’s disease. J Hand Surg Am 35:2039-2045, 2010. Abstract

Pan ZJ, Maier S, Schwarz K, Azbill J, Akira S, Uematsu S, Farris AD. Toll-like receptor 7 (TLR7) modulates anti-nucleosomal autoantibody isotype and renal complement deposition in mice exposed to syngeneic late apoptotic cells. Ann Rheum Dis 69:1195-1199, 2010. Abstract

Rider LG, Wu L, Mamyrova G, Targoff IN, Miller FW, Childhood Myositis Heterogeneity Collaborative Study Group. Environmental factors preceding illness onset differ in phenotypes of the juvenile idiopathic inflammatory myopathies. Rheumatology (Oxford) 49:2381-2390, 2010. Abstract

Saban MR, Sferra TJ, Davis CA, Simpson C, Allen A, Maier J, Fowler B, Knowlton N, Birder L, Wu XR, Saban R. Neuropilin-VEGF signaling pathway acts as a key modulator of vascular, lymphatic, and inflammatory cell responses of the bladder to intravesical BCG treatment. Am J Physiol Renal Physiol 299:F1245-F1256, 2010. Abstract

Sanchez E, Webb RD, Rasmussen A, Kelly JA, Riba L, Kaufman KM, Garcia de la Torre I, Moctezuma JF, Maradiaga-Ceceña MA, Cardiel-Rios MH, Acevedo E, Cucho-Venegas M, Garcia MA, Gamron S, Pons-Estel BA, Vasconcelos C, Martin J, Tusié-Luna T, Harley JB, Richardson B, Sawalha AH, Alarcón-Riquelme ME. Genetically determined Amerindian ancestry correlates with increased frequency of risk alleles for systemic lupus erythematosus. Arthritis Rheum 62:3722-3729, 2010. Abstract

Shen N, Fu Q, Deng Y, Qian X, Zhao J, Kaufman KM, Wu YL, Yu CY, Tang Y, Chen JY, Yang W, Wong M, Kawasaki A, Tsuchiya N, Sumida T, Kawaguchi Y, Howe HS, Mok MY, Bang SY, Liu FL, Chang DM, Takasaki Y, Hashimoto H, Harley JB, Guthridge JM, Grossman JM, Cantor RM, Song YW, Bae SC, Chen S, Hahn BH, Lau YL, Tsao BP. Sex-specific association of X-linked Toll-like receptor 7 (TLR7) with male systemic lupus erythematosus. Proc Natl Acad Sci U S A 107:15838-15843, 2010. Abstract

Szodoray P, Alex P, Knowlton N, Centola M, Dozmorov I, Csipo I, Nagy AT, Constantin T, Ponyi A, Nakken B, Danko K. Idiopathic inflammatory myopathies, signified by distinctive peripheral cytokines, chemokines and the TNF family members B-cell activating factor and a proliferation inducing ligand. Rheumatology (Oxford) 49:1867-1877, 2010. Abstract

Te JL, Dozmorov IM, Guthridge JM, Nguyen KL, Cavett JW, Kelly JA, Bruner GR, Harley JB, Ojwang JO. Identification of unique microRNA signature associated with lupus nephritis. PLoS ONE 5:e10344, 2010. Abstract

Cardiovascular Biology Research Program

Chichili GR, Westmuckett A, Rodgers W. T cell signal regulation by the actin cytoskeleton. J Biol Chem 285:14737-14746, 2010. Abstract

Danan LM, Yu Z, Ludden PJ, Jia W, Moore KL, Leary JA. Catalytic mechanism of Golgi-resident human Tyrosylprotein Sulfotransferase-2: a mass spectrometry approach. J Am Soc Mass Spectrom 21:1633-1642, 2010. Abstract

Esmon CT. Far from the Heart: Counteracting coagulation. Nat Med 16:759-760, 2010. Abstract

Esmon CT. The discovery of the endothelial cell protein C receptor. J Thromb Haemost 8:2-5, 2010. Abstract

He Y, Zhang H, Yu L, Gunel M, Boggon TJ, Chen H, Min W. Stabilization of VEGFR2 signaling by cerebral cavernous malformation 3 is critical for vascular development. Sci Signal 3:ra26, 2010. Abstract

Jones D, Xu Z, Zhang H, He Y, Kluger MS, Chen H, Min W. Functional analyses of the bone marrow kinase in the X chromosome in vascular endothelial growth factor-induced lymphangiogenesis. Arterioscler Thromb Vasc Biol 30:2553-2561, 2010. Abstract

Ko G, Paradise S, Chen H, Graham M, Vecchi M, Bianchi F, Cremona O, Di Fiore PP, De CP. Selective high-level expression of epsin 3 in gastric parietal cells, where it is localized at endocytic sites of apical canaliculi. Proc Natl Acad Sci U S A 107:21511-21516, 2010. Abstract

Liu Z, Miner JJ, Yago T, Yao L, Lupu F, Xia L, McEver RP. Differential regulation of human and murine P-selectin expression and function in vivo. J Exp Med 207:2975-2987, 2010. Abstract

McEver RP. Rolling back neutrophil adhesion. Nat Immunol 11:282-284, 2010. (Comment)

McEver RP, Zhu C. Rolling cell adhesion. Annu Rev Cell Dev Biol 26:363-369, 2010. Abstract

Nagai M, Yilmaz CE, Kirchhofer D, Esmon CT, Mackman N, Granger DN. Role of coagulation factors in cerebral venous sinus and cerebral microvascular thrombosis. Neurosurgery 66:560-566, 2010. Abstract

Nagai M, Terao S, Yilmaz G, Yilmaz CE, Esmon CT, Watanabe E, Granger DN. Roles of inflammation and the activated protein C pathway in the brain edema associated with cerebral venous sinus thrombosis. Stroke 41:147-152, 2010. Abstract

Popescu NI, Lupu C, Lupu F. Extracellular protein disulfide isomerase regulates coagulation on endothelial cells through modulation of phosphatidylserine exposure. Blood 116:993-1001, 2010. Abstract

Popescu NI, Lupu C, Lupu F. Role of PDI in regulating tissue factor: FVIIa activity. Thromb Res 125:S38-S41, 2010. Abstract

Silasi-Mansat R, Zhu H, Popescu NI, Peer G, Sfyroera G, Magotti P, Ivanciu L, Lupu C, Mollnes TE, Taylor FB, Kinasewitz G, Lambris JD, Lupu F. Complement inhibition decreases the procoagulant response and confers organ protection in a baboon model of Escherichia coli sepsis. Blood 116:1002-1010, 2010. Abstract

Starr ME, Ueda J, Takahashi H, Weiler H, Esmon CT, Evers BM, Saito H. Age-dependent vulnerability to endotoxemia is associated with reduction of anticoagulant factors activated protein C and thrombomodulin. Blood 115:4886-4893, 2010. Abstract

Wang Y, Ju T, Ding X, Xia B, Wang W, Xia L, He M, Cummings RD. Cosmc is an essential chaperone for correct protein O-glycosylation. Proc Natl Acad Sci U S A 107:9228-9233, 2010. Abstract

Wayman AM, Chen W, McEver RP, Zhu C. Triphasic force dependence of E-selectin/ligand dissociation governs cell rolling under flow. Biophys J 99:1166-1174, 2010. Abstract

Xia L. Core 3-derived O-Glycans are essential for intestinal mucus barrier function. Methods Enzymol 479C:123-141, 2010. Abstract

Xie D, Gore C, Liu J, Pong RC, Mason R, Hao G, Long M, Kabbani W, Yu L, Zhang H, Chen H, Sun X, Boothman DA, Min W, Hsieh JT. Role of DAB2IP in modulating epithelial-to-mesenchymal transition and prostate cancer metastasis. Proc Natl Acad Sci U S A 107:2485-2490, 2010. Abstract

Xu J, Lupu F, Esmon CT. Inflammation, innate immunity and blood coagulation. Hamostaseologie 30:5-9, 2010. Abstract

Yago T, Fu J, McDaniel JM, Miner JJ, McEver RP, Xia L. Core 1-derived O-glycans are essential E-selectin ligands on neutrophils. Proc Natl Acad Sci U S A 107:9204-9209, 2010. Abstract

* Yago T, Shao B, Miner JJ, Yao L, Klopocki AG, Maeda K, Coggeshall KM, McEver RP. E-selectin engages PSGL-1 and CD44 through a common signaling pathway to induce integrin {alpha}L{beta}2-mediated slow leukocyte rolling. Blood 116:485-494, 2010. Abstract

Yu L, Ji W, Zhang H, Renda MJ, He Y, Lin S, Cheng EC, Chen H, Krause DS, Min W. SENP1-mediated GATA1 deSUMOylation is critical for definitive erythropoiesis. J Exp Med 207:1183-1195, 2010. Abstract

Cell Cycle and Cancer Biology Research Program

Bardhan A, Chuong H, Dawson DS. Meiotic cohesin promotes pairing of nonhomologous centromeres in early meiotic prophase. Mol Biol Cell 21:1799-1809, 2010. Abstract

Gorbsky GJ. Duct tape for broken chromosomes. Cell 140:178-180, 2010. Abstract

Havens KA, Gardner MK, Kamieniecki RJ, Dresser ME, Dawson DS. Slk19 of Saccharomyces cerevisiae regulates anaphase spindle dynamics through two independent mechanisms. Genetics 186:1247-1260, 2010. Abstract

Hu L, Potapova TA, Li S, Rankin S, Gorbsky GJ, Angeletti PC, Ceresa BP. Expression of HPV16 E5 produces enlarged nuclei and polyploidy through endoreplication. Virology 405:342-351, 2010. Abstract

Lafont AL, Song J, Rankin S. Sororin cooperates with the acetyltransferase Eco2 to ensure DNA replication-dependent sister chromatid cohesion. Proc Natl Acad Sci U S A 107:20364-20369, 2010. Abstract

Obeso D, Dawson DS. Temporal characterization of homology-independent centromere coupling in meiotic prophase. PLoS ONE 5:e10336, 2010. Abstract

Wang F, Dai J, Daum JR, Niedzialkowska E, Banerjee B, Stukenberg PT, Gorbsky GJ, Higgins JM. Histone H3 Thr-3 phosphorylation by haspin positions Aurora B at centromeres in mitosis. Science 330:231-235, 2010. Abstract

Clinical Pharmacology Research Program

Bruce IN, Gordon C, Merrill JT, Isenberg D. Clinical trials in lupus: what have we learned so far?: Understanding the gap between reality and expectation. Rheumatology (Oxford) 49:1025-1027, 2010. Abstract

Hanly JG, Urowitz MB, Su L, Bae SC, Gordon C, Wallace DJ, Clarke A, Bernatsky S, Isenberg D, Rahman A, Alarcón GS, Gladman DD, Fortin PR, Sanchez-Guerrero J, Romero-Diaz J, Merrill JT, Ginzler E, Bruce IN, Steinsson K, Khamashta M, Petri M, Manzi S, Dooley MA, Ramsey-Goldman R, van Vollenhoven R., Nived O, Sturfelt G, Aranow C, Kalunian K, Ramos-Casals M, Zoma A, Douglas J, Thompson K, Farewell V, Systemic Lupus International Collaborating Clinics (SLICC). Prospective analysis of neuropsychiatric events in an international disease inception cohort of patients with systemic lupus erythematosus. Ann Rheum Dis 69:529-535, 2010. Abstract

Merrill JT, Burgos-Vargas R, Westhovens R, Chalmers A, D’Cruz D, Wallace DJ, Bae SC, Sigal L, Becker JC, Kelly S, Raghupathi K, Li T, Peng Y, Kinaszczuk M, Nash P. The efficacy and safety of abatacept in patients with non-life-threatening manifestations of systemic lupus erythematosus: results of a twelve-month multicenter exploratory, phase IIB, randomized, double blind, placebo-controlled trial. Arthritis Rheum 62:3077-3087, 2010. Abstract

Merrill JT, Buyon JP. Rituximab: Wanted dead or alive.. Arthritis Rheum 72:2188-2191, 2010. Abstract

Merrill JT, Neuwelt CM, Wallace DJ, Shanahan JC, Latinis KM, Oates JC, Utset TO, Gordon C, Isenberg DA, Hsieh HJ, Zhang D, Brunetta PG. Efficacy and safety of rituximab in moderately-to-severely active systemic lupus erythematosus: The randomized, double-blind, phase II/III systemic lupus erythematosus evaluation of rituximab trial. Arthritis Rheum 62:222-233, 2010. Abstract

Olech E, Crues JV, III, Yocum DE, Merrill JT. Bone marrow edema Is the most specific finding for Rheumatoid Arthritis (RA) on noncontrast magnetic resonance imaging of the hands and wrists: A comparison of patients with RA and healthy controls. J Rheumatol 37:265-274, 2010. Abstract

Reiss AB, Anwar K, Merrill JT, Chan ES, Awadallah NW, Cronstein BN, Belmont HM, Belilos E, Rosenblum G, Belostocki K, Bonetti L, Hasneen K, Carsons SE. Plasma from systemic lupus patients compromises cholesterol homeostasis: a potential mechanism linking autoimmunity to atherosclerotic cardiovascular disease. Rheumatol Int 30:591-598, 2010.Abstract

Suh CH, Hilliard BA, Li S, Merrill JT, Cohen PL. TAM receptor ligands in lupus: Protein S but not Gas6 levels reflect disease activity in systemic lupus erythematosus. Arthritis Res Ther 12:R146, 2010. Abstract

Urowitz MB, Gladman D, Ibanez D, Bae SC, Sanchez-Guerrero J, Gordon C, Clarke A, Bernatsky S, Fortin PR, Hanly JG, Wallace DJ, Isenberg D, Rahman A, Alarcon GS, Merrill JT, Ginzler E, Khamashta M, Nived O, Sturfelt G, Bruce IN, Steinsson K, Manzi S, Ramsey-Goldman R, Dooley MA, Zoma A, Kalunian K, Ramos M, Van Vollenhoven RF, Aranow C, Stoll T, Petri M, Maddison P, Systemic Lupus International Collaborating Clinics. Atherosclerotic vascular events in a multinational inception cohort of systemic lupus erythematosus. Arthritis Care Res (Hoboken ) 62:881-887, 2010. Abstract

Experimental Therapeutics Research Laboratory

Gomez-Mejiba SE, Zhai Z, Gimenez MS, Ashby MT, Chilakapati J, Kitchin K, Mason RP, Ramirez DC. Myeloperoxidase-induced genomic DNA-centered radicals. J Biol Chem 285:20062-20071, 2010. Abstract

Ranguelova K, Chatterjee S, Ehrenshaft M, Ramirez DC, Summers FA, Kadiiska MB, Mason RP. Protein radical formation resulting from eosinophil peroxidase-catalyzed oxidation of sulfite. J Biol Chem 285:24195-24205, 2010. Abstract

Sueishi Y, Miyata A, Yoshioka D, Kamibayashi M, Kotake Y. Influence of the glucosylated beta-cyclodextrin inclusion on sulfur trioxide spin-adduct stabilizations and spin-trapping rate processes for DMPO-type spin traps. J Incl Phenom Macrocycl Chem 66:357-364, 2010.

Sueishi Y, Yoshioka D, Oowada S, Endoh N, Kohri S, Fujii H, Shimmei M, Kotake Y. Is the oxygen radical absorbance capacity (ORAC) method a peroxyl-radical scavenging assay? Z Phys Chem 224:921-928, 2010.

Free Radical Biology and Aging Research Program

Churchill EN, Ferreira JC, Brum PC, Szweda LI, Mochly-Rosen D. Ischemic preconditioning improves proteasomal activity and increases the degradation of {delta}PKC during reperfusion. Cardiovasc Res 85:385-394, 2010. Abstract

Costello KE, Guilak F, Setton LA, Griffin TM. Locomotor activity and gait in aged mice deficient for Type IX collagen. J Appl Physiol 109:211-219, 2010. Abstract

Cussiol JR, Alegria TG, Szweda LI, Netto LE. Ohr (organic hydroperoxide resistance protein) possesses a previously undescribed activity: lipoyl-dependent peroxidase. J Biol Chem 285:21943-21950, 2010. Abstract

Dibello PM, Dayal S, Kaveti S, Zhang D, Kinter M, Lentz SR, Jacobsen DW. The Nutrigenetics of hyperhomocysteinemia.quantitative proteomics reveals differences in the methionine cycle enzymes of gene-induced versus diet-induced hyperhomocysteinemia. Mol Cell Proteomics 9:471-485, 2010. Abstract

Griesel BA, Weems J, Russell RA, Abel ED, Humphries K, Olson AL. Acute inhibition of fatty acid import inhibits GLUT4 transcription in adipose tissue, but not skeletal or cardiac muscle tissue, partly through liver X receptor (LXR) signaling. Diabetes 59:800-807, 2010. Abstract

Griffin TM, Fermor B, Huebner JL, Kraus VB, Rodriguiz RM, Wetsel WC, Cao L, Setton LA, Guilak F. Diet-induced obesity differentially regulates behavioral, biomechanical, and molecular risk factors for osteoarthritis in mice. Arthritis Res Ther 12:R130, 2010. Abstract

Jagannathan R, Kaveti S, Desnoyer RW, Willard B, Kinter M, Karnik SS. AT1 receptor induced alterations in histone H2A reveal novel insights into GPCR control of chromatin remodeling. PLoS ONE 5:e12552, 2010. Abstract

Genetic Models of Disease Research Program

Clarke M. Recent insights into host-pathogen interactions from Dictyostelium. Cell Microbiol 12:283-291, 2010. Abstract

Clarke M, Engel U, Giorgione J, Muller-Taubenberger A, Prassler J, Veltman D, Gerisch G. Curvature recognition and force generation in phagocytosis. BMC Biol 8:154, 2010. Abstract

Clarke M, Maddera L, Engel U, Gerisch G. Retrieval of the vacuolar H-ATPase from phagosomes revealed by live cell imaging. PLoS ONE 5:e8585, 2010. Abstract

Flibotte S, Edgley ML, Chaudhry I, Taylor J, Neil SE, Rogula A, Zapf R, Hirst M, Butterfield Y, Jones SJ, Marra MA, Barstead RJ, Moerman DG. Whole-genome profiling of mutagenesis in Caenorhabditis elegans. Genetics 185:431-441, 2010. Abstract

Hunter JW, Mullen GP, McManus JR, Heatherly JM, Duke A, Rand JB. Neuroligin-deficient mutants of C. elegans have sensory processing deficits and are hypersensitive to oxidative stress and mercury toxicity. Dis Model Mech 3:366-376, 2010. Abstract

Moulder GL, Cremona GH, Duerr J, Stirman JN, Fields SD, Martin W, Qadota H, Benian GM, Lu H, Barstead RJ. alpha-actinin is required for the proper assembly of Z-disk/focal adhesion-like structures and for efficient locomotion in Caenorhabditis elegans. J Mol Biol 403:516-528, 2010. Abstract

Silverman PM, Clarke MB. New insights into F-pilus structure, dynamics, and function. Integr Biol (Camb ) 2:25-31, 2010. Abstract

Immunobiology and Cancer Research Program

An G, Miner CA, Nixon JC, Kincade PW, Bryant J, Tucker PW, Webb CF. Loss of Bright/ARID3a function promotes developmental plasticity. Stem Cells 28:1560-1567, 2010. Abstract

Ernst PB, Garrison JC, Thompson LF. Much ado about adenosine: adenosine synthesis and function in regulatory T cell biology. J Immunol 185:1993-1998, 2010. Abstract

Hu T, Simmons A, Yuan J, Bender TP, Alberola-Ila J. The transcription factor c-Myb primes CD4(+)CD8(+) immature thymocytes for selection into the iNKT lineage. Nat Immunol 11:435-441, 2010. Abstract

Ichii M, Oritani K, Yokota T, Schultz DC, Holter JL, Kanakura Y, Kincade PW. Stromal cell-free conditions favorable for human B lymphopoiesis in culture. J Immunol Methods 359:47-55, 2010. Abstract

Ichii M, Oritani K, Yokota T, Zhang Q, Garrett KP, Kanakura Y, Kincade PW. The density of CD10 corresponds to commitment and progression in the human B lymphoid lineage. PLoS ONE 5:e12954, 2010. Abstract

Ichii M, Shimazu T, Welner RS, Garrett KP, Zhang Q, Esplin BL, Kincade PW. Functional diversity of stem and progenitor cells with B-lymphopoietic potential. Immunol Rev 237:10-21, 2010. Abstract

Iyer JK, Khurana T, Langer M, West CM, Ballard JD, Metcalf JP, Merkel TJ, Coggeshall KM. Inflammatory cytokine response to Bacillus anthracis peptidoglycan requires phagocytosis and lysosomal trafficking. Infect Immun 78:2418-2428, 2010. Abstract

Jin D, Fan J, Wang L, Thompson LF, Liu A, Daniel BJ, Shin T, Curiel TJ, Zhang B. CD73 on tumor cells impairs antitumor T-cell responses: a novel mechanism of tumor-induced immune suppression. Cancer Res 70:2245-2255, 2010. Abstract

Kincade PW. Plasticity of supporting cells in a stem cell factory. Immunity 33:291-293, 2010. Abstract

Lam QL, Wang S, Ko OK, Kincade PW, Lu L. Leptin signaling maintains B-cell homeostasis via induction of Bcl-2 and Cyclin D1. Proc Natl Acad Sci U S A 107:13812-13817, 2010. Abstract

Maeda K, Mehta H, Drevets DA, Coggeshall KM. IL-6 increases B cell IgG production in a feed-forward pro-inflammatory mechanism to skew hematopoiesis and elevate myeloid production. Blood 115:4699-4706, 2010. Abstract

Peng Q, Malhotra S, Torchia JA, Kerr WG, Coggeshall KM, Humphrey MB. TREM2- and DAP12-dependent activation of P13K requires DAP10 and is inhibited by SHIP1. Sci Signal 3:ra38, 2010. Abstract

Wu W, Booth JL, Duggan ES, Patel KB, Coggeshall KM, Metcalf JP. Human lung innate immune cytokine response to adenovirus type 7. J Gen Virol 91:1155-1163, 2010. Abstract

Wu W, Booth JL, Duggan ES, Wu S, Patel KB, Coggeshall KM, Metcalf JP. Innate immune response to H3N2 and H1N1 influenza virus infection in a human lung organ culture model. Virology 396:178-188, 2010. Abstract

Protein Studies Research Program

Huang B, Wu H, Hao N, Blombach F, van der Oost J, Li X, Zhang XC, Rao Z. Functional study on GTP hydrolysis by the GTP-binding protein from Sulfolobus solfataricus, a member of the HflX family. J Biochem 148:103-113, 2010. Abstract

Li X, Bo H, Zhang XC, Hartsuck JA, Tang J. Predicting memapsin 2 (beta-secretase) hydrolytic activity. Protein Sci 19:2175-2185, 2010. Abstract

Wu H, Sun L, Blombach F, Brouns SJ, Snijders AP, Lorenzen K, van den Heuvel RH, Heck AJ, Fu S, Li X, Zhang XC, Rao Z, van der Oost J. Structure of the ribosome associating GTPase HflX. Proteins 78:705-713, 2010. Abstract

Zhang Z, Zhu W, Lapolla SM, Miao Y, Shao Y, Falcone M, Boreham D, McFarlane N, Ding J, Johnson AE, Zhang XC, Andrews DW, Lin J. Bax forms an oligomer via separate, yet interdependent, surfaces. J Biol Chem 285:17614-17627, 2010. Abstract

* Indicates publications by more than one department.

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