Evaluation of imputation-based association in and around the integrin-alpha-M (ITGAM) gene and replication of robust association between a non-synonymous functional variant within ITGAM and systemic lupus erythematosus (SLE).
Patients with familial and sporadic onset SLE have similar clinical profiles but vary profoundly by race.
Interferon regulatory factor-5 is genetically associated with systemic lupus erythematosus in African Americans.