Lysed cell models and isolated chromosomes for the study of kinetochore/centromere biochemistry in vitro.
Cell-based expression cloning for identification of polypeptides that hypersensitize mammalian cells to mitotic arrest.
Inhibition of TRIP1/S8/hSug1, a component of the human 19S proteasome, enhances mitotic apoptosis induced by spindle poisons.
Polo-like kinase 1 creates the tension-sensing 3F3/2 phosphoepitope and modulates the association of spindle-checkpoint proteins at kinetochores.
