Jacob Brown, Ph.D.
Research Assistant Professor
Aging & Metabolism Research Program
Research
I originally became interested in skeletal muscle because of my love for exercise, which lead me to pursue a research career studying skeletal muscle biology. My broad research interests include understanding the underlying metabolic changes in skeletal muscle that trigger muscle atrophy in (patho) physiological conditions such as aging and cancer cachexia. Skeletal muscle is important for maintaining our quality of life and our overall health, so understanding underlying mechanisms that contribute to skeletal muscle loss and dysfunction is a worthwhile area of study.
Over the past few years, my laboratory focus has been on understanding how oxylipins contribute to skeletal muscle pathologies. Oxylipins are lipid signaling molecules that are generated from polyunsaturated fatty acids. Oxylipins have a variety of different functions in skeletal muscle; however, my recent research suggests that some species of oxylipins play a role in triggering skeletal muscle pathology. My current research focuses on identifying oxylipins that may impact skeletal muscle health.
Publications
Thadathil N, Selvarani R, Mohammed S, Nicklas EH, Tran AL, Kamal M, Luo W, Brown JL, Lawrence MM, Borowik AK, Miller BF, Van Remmen H, Richardson A, Deepa SS. Senolytic treatment reduces cell senescence and necroptosis in Sod1 knockout mice that is associated with reduced inflammation and hepatocellular carcinoma. Aging Cell. 2022 Aug;21(8):e13676. doi: 10.1111/acel.13676. Epub 2022 Jul 23. PMID: 35869934, PMCID: PMC9381894
Washington TA, Haynie WS, Schrems ER, Perry Jr RA, Brown LA, Williams BM, Rosa-Caldwell ME, Lee DE, Brown JL. Effects of PGC-1α overexpression on the myogenic response during skeletal muscle regeneration. Sports Med Health Sci. 2022 Jul 20;4(3):198-208. doi: 10.1016/j.smhs.2022.06.005. eCollection 2022 Sep. PMID: 36090923, PMCID: PMC9453693
Morena da Silva F, Rosa-Caldwell ME, Schrems ER, Martinez L, Amos MG, Lim S, Cabrera AR, Brown JL, Washington TA, Greene NP. PGC-1α overexpression is not sufficient to mitigate cancer cachexia in either male or female mice. Appl Physiol Nutr Metab. 2022 Sep 1;47(9):933-948. doi: 10.1139/apnm-2022-0086. Epub 2022 Jun 14.
Rosa-Caldwell ME, Haynie WS, Lim S, Brown JL, Lee DE, Dunlap KR, Jansen LT, Washington TA, Wiggs MP, Greene NP. Mitochondrial Aberrations during the Progression of Disuse Atrophy Differentially Affect Male and Female Mice. Journal of Cachexia Sarcopenia Muscle. 2021 Dec;12(6):2056-2068. doi: 10.1002/jcsm.12809. PMID: 34585846, PMCID: PMC8718086
Contact
Aging & Metabolism Research Program, MS 46
Oklahoma Medical Research Foundation
825 N.E. 13th Street
Oklahoma City, OK 73104
Phone: 405-271-2653
E-mail: Jacob-Brown@omrf.org
