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Home - ORDRCC Cohorts

ORDRCC Cohorts

Lupus Family Registry and Repository (LFRR)

  • Collected samples from >12,300 enrolled participants
  • Samples include potential SLE cases family members, and healthy controls
    • Detailed clinical information including:
      • Questionnaires
      • Disease Activity Measurements
      • Abstracted medical records
      • Longitudinal clinical visit information
    • All participants tested for standard SLE serology tests
    • Extensive genetic information available for most individuals
    • Valuable research resource
      • >420,000 sample aliquots are available
      • DNA, RNA, sera, plasma, EBV transformed cell lines, and PBMCs

Oklahoma Rheumatic Disease Cohort (ORDC)

Oklahoma Lupus Cohort (OLC)

  • Contains longitudinal samples from SLE patients with anti-phospholipid antibodies
  • Approximately 650 individuals followed every three months
  • Some individuals have been followed for over 15 years
  • Detailed clinical information including:
    • Serial standard disease activity
    • Damage scores and other clinical measures

Oklahoma Rheumatoid Arthritis Cohorts

  • Serial samples and clinical information from approximately 450 rheumatoid arthritis subjects with serial MRI evaluations of their joints
  • Sample derivatives include serum, DNA, RNA, and some PBMCs
  • Detailed clinical data available for all participants

Department of Defense Serum Repository (DODSR)

  • Over 1000 serum samples with an average of 5 samples per case
  • All patients had at least one sample prior to diagnosis
  • Over 50% of cases also have serum samples after diagnosis

SLE Blood Relative Follow-Up Cohort (SBRFC)

  • Blood relatives of lupus patients at higher risk of developing SLE
  • Enrolled over 400 individuals who provided complete information/samples

Oklahoma Immune Cohort (OIC)

  • Over 700 health individuals
  • Over 50 ANA+ healthy individuals
  • Screened for dsDNA, Chromatin, RiboP, Ro, La, Sm, SmRNP, RNP, Centromere B, Scl-70, Jo-1

Oklahoma Clinical Immunology Serum Cohort (OCIS)

  • This collection holds >70,000 de-identified, remnant patient samples
  • Nearly every serum obtained from a patient with a positive ANA (or other evidence of autoimmune disease) has been saved for future investigation
  • A comprehensive database allows coded samples to be selected by serological criteria

Undifferentiated Connective Tissue Disease (UCTD)

  • Approximately 150 individuals have been seen in the Oklahoma Rheumatic Disease Cohort who initially presented with undifferentiated connective tissue disease
  • Some of these have since transitioned to SLE, RA, Sjogren’s, or systemic sclerosis, while many others have remained UCTD
  • Serial clinical data and samples are available on these individuals
  • Patients are continually being added to this cohort
  • Serves as a patient base for the new lupus prevention trial, Study of anti-Malarials in Incomplete Lupus Erythematosus (SMILE)

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