ORDRCC Cohorts

Lupus Family Registry and Repository (LFRR)

• Collected samples from >12,300 enrolled participants
• Samples include potential SLE cases family members, and healthy controls
  • Detailed clinical information including:
    • Questionnaires
    • Disease Activity Measurements
    • Abstracted medical records
    • Longitudinal clinical visit information
  • All participants tested for standard SLE serology tests
  • Extensive genetic information available for most individuals
  • Valuable research resource
    • >420,000 sample aliquots are available
    • DNA, RNA, sera, plasma, EBV transformed cell lines, and PBMCs

Oklahoma Rheumatic Disease Cohort (ORDC)

Oklahoma Lupus Cohort (OLC)

• Contains longitudinal samples from SLE patients with anti-phospholipid antibodies
• Approximately 650 individuals followed every three months
• Some individuals have been followed for over 15 years
• Detailed clinical information including:
  • Serial standard disease activity
  • Damage scores and other clinical measures

Oklahoma Rheumatoid Arthritis Cohorts

• Serial samples and clinical information from approximately 450 rheumatoid arthritis subjects with serial MRI evaluations of their joints
• Sample derivatives include serum, DNA, RNA, and some PBMCs
• Detailed clinical data available for all participants

Department of Defense Serum Repository (DODSR)

• Over 1000 serum samples with an average of 5 samples per case
• All patients had at least one sample prior to diagnosis
• Over 50% of cases also have serum samples after diagnosis

SLE Blood Relative Follow-Up Cohort (SBRFC)

• Blood relatives of lupus patients at higher risk of developing SLE
• Enrolled over 400 individuals who provided complete information/samples

Oklahoma Immune Cohort (OIC)

• Over 700 health individuals
• Over 50 ANA+ healthy individuals
• Screened for dsDNA, Chromatin, RiboP, Ro, La, Sm, SmRNP, RNP, Centromere B, Scl-70, Jo-1

Oklahoma Clinical Immunology Serum Cohort (OCIS)

• This collection holds >70,000 de-identified, remnant patient samples
• Nearly every serum obtained from a patient with a positive ANA (or other evidence of autoimmune disease) has been saved for future investigation
• A comprehensive database allows coded samples to be selected by serological criteria

Undifferentiated Connective Tissue Disease (UCTD)

• Approximately 150 individuals have been seen in the Oklahoma Rheumatic Disease Cohort who initially presented with undifferentiated connective tissue disease
• Some of these have since transitioned to SLE, RA, Sjogren’s, or systemic sclerosis, while many others have remained UCTD
• Serial clinical data and samples are available on these individuals
• Patients are continually being added to this cohort
• Serves as a patient base for the new lupus prevention trial, Study of anti-Malarials in Incomplete Lupus Erythematosus (SMILE)