When a scientist receives a grant, that’s great news. The funding provides the means for a scientist to explore a hypothesis and run his or her lab. But those grants are not unlimited; they provide funding only for a set period of time, typically three to five years. But for OMRF’s Dr. Paul Kincade, one grant has proven the medical research equivalent of the Energizer Bunny.
First awarded to Kincade when Richard Nixon was President and bell bottoms were the rage, Early events in mammalian B-cell differentiation has remained funded for a whopping 38 years. Kincade attributes this success, which includes seven separate renewals of the grant, to hard work, a steady stream of new findings and, of course, a little bit of luck. Still, after almost 40 years, does anything remain to be learned about this particular topic?
“The human immune system is an incredibly intricate machine, and every day we learn something new about how it develops and functions,” says Kincade, who holds the William H. and Rita Bell Chair in Biomedical Research at OMRF. “That knowledge continues to help us better understand and treat diseases like lupus, leukemias and lymphomas.”
Grants Awarded
January – June, 2012
Dr. José Alberola-Ila
Hematopoietic stem cell senescence
Dr. Yunzhou Dong
Role of epsins in atherosclerosis; Drug development for prostate cancer
Dr. Michael Dresser
Zeiss LSM710 confocal fluorescence microscope for live stem-cell imaging; Mechanics and regulation of chromosome dynamics in meiotic prophase
Dr. Taishan Hu
RAS/MAPK cascade controls iNKT cell development and function
Dr. Kenneth Humphries
Mitochondrial dysfunction in amyotrophic lateral sclerosis
Dr. Judith A. James
Oklahoma Autoimmunity Center for Excellence
Dr. Paul W. Kincade
Hematopoietic stem cell senescence; Early events in mammalian B-cell differentiation
Dr. Hui-Ying Lim
A fluorescence stereomicroscope for characterization of adult stem cells in intact tissues of various model systems
Dr. Florea Lupu
Spinning disk confocal microscope for intravital imaging; Complement inhibition as sepsis therapy
Dr. Rodger P. McEver
Interdisciplinary research in vascular biology; Cellular regulation of selectin-ligand interactions; Mechanisms for blood cell adhesion under flow; Protein-glycan interactions in the vascular system
Dr. Joan Merrill
Clinical outcomes and quality of life of lupus nephritis patients in a prospective international inception cohort
Dr. Kenneth G. Miller
Signaling pathways that regulate synaptic transmission
Dr. Courtney Montgomery
Comprehensive genome interrogation of African-American sarcoidosis families
Dr. Swapan K. Nath
SLE susceptibility and clinical significance at 2q22-24 across multiple ethnicities; Identification of lupus predisposing variants by comparing multiple populations
Dr. Xiao-Hong Sun
Notch-induced protein degradation in lymphopoiesis
Dr. Linda Thompson
Fluorescence activated cell sorters upgrade
Dr. Weidong Wang
An automated high-throughput microscope for adult stem cell research in Oklahoma
Dr. Lijun Xia
Role of mucin-type O-glycans in intestinal inflammation; Microtome for histological analysis of adult stem cell based therapies
