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My Research
I lead a translational molecular and cellular neuroimmunology research program. We aim to understand neuroimmunologic mechanisms and apply novel therapeutics in central nervous system demyelinating diseases, including multiple sclerosis, neuromyelitis optica and myelin oligodendrocyte glycoprotein antibody disease, known as MOGAD.
My lab pursues bench-to-bedside-and-back translational and clinical studies. We have established MS and other neuroinflammatory disease biorepositories and conducted comprehensive immunological studies on immune cells in MS. Our studies span from the analysis of immune cell type and function to biomarker discovery for disease flares and progression, as well as early disease-initiating mechanisms and the mechanisms of current MS drugs.
- Disease Initiation – How do genetic and environmental factors, including smoking, infection and the microbiome, impact disease onset?
- Disease Treatment – What are the mechanisms of current disease-modifying therapies, predictors of relapse, and treatment responses?
- Disease Progression – How can we slow or stop the progression of MS and related disease?
My goal is to broaden the scope of autoimmune disease research in collaboration with other experts in lupus, sarcoidosis and Sjögren’s disease. Our ultimate aim is to provide a comprehensive understanding of human immune function in health and through various disease courses, not only in autoimmune but also other neurodegenerative diseases.
Research Keywords
- Multiple sclerosis
- Autoimmune disease
- Personalized medicine
Contact
Yang Mao-Draayer, M.D., Ph.D.
Multiple Sclerosis Center of Excellence
Arthritis & Clinical Immunology Research Program, MS 50
Oklahoma Medical Research Foundation
825 N.E. 13th Street
Oklahoma City, OK 73104
Phone: 405-271-7291
