In multiple sclerosis, the body’s immune system attacks the protective sheath that covers the nerves. The resulting nerve damage causes a variety of symptoms, including vision loss, painful spasms, weakness, numbness, sensory changes and difficulty walking. The disease can be debilitating and, too often, devastating to patients.
At OMRF’s Multiple Sclerosis Center of Excellence, we utilize a whole-disease model, where our care teams focus on the spectrum of needs of individual patients to help speed recovery from attacks, modify the course of the disease, and manage symptoms. We have the ability to treat spasticity, a condition that occurs when muscles become stiff or spasm involuntarily. This muscle disorder, caused by a signal disparity in the central nervous system, is a common symptom of MS. Here we have the expertise to treat it with onsite physical therapy.
In addition to treating those with MS, we collect biological samples from patient volunteers. These research materials enable scientists in our laboratories to search for biomarkers — naturally occurring, measurable biological occurrences — that can tell us which medications might work best for particular patients. It’s all part of our bench-to-bedside commitment to better understanding this complex disease.
M.D., Universidad Mexico Americana del Norte, Reynosa, Tamaulipas, Mexico, 1997
B.S., Colegio Nacional de Medicina Homeopatica y Naturismo, Bogota, Cundinamarca, Colombia, 1995
Garrido-Sanabria ER, Perez MG, Banuelos C, Reyna T, Hernandez S, Castaneda MT, Colom LV. Electrophysiological and morphological heterogeneity of slow firing neurons in medial septal/diagonal band complex as revealed by cluster analysis. Neuroscience 146: 931-945, 2007. [Abstract]
Colom LV, Castaneda MT, Reyna T, Hernandez S, Garrido-Sanabria E. Characterization of medial septal glutamatergic neurons and their projection to the hippocampus. Synapse 58: 151-164, 2005. [Abstract]
Castaneda MT, Sanabria ER, Hernandez S, Ayala A, Reyna TA, Wu JY, Colom LV. Glutamic acid decarboxylase isoforms are differentially distributed in the septal region of the rat. Neurosci Res 52: 107-119, 2005. [Abstract]
Arthritis & Clinical Immunology Research Program, MS 50
Oklahoma Medical Research Foundation
825 N.E. 13th Street
Oklahoma City, OK 73104
Phone: (405) 271-6241
Fax: (405) 271-2887