2005 Scientific Publications

Arthritis Research Program

* Aston CE, Ralph DA, Lalo DP, Manjeshwar S, Gramling BA, Defreese DC, West AD, Branam DE, Thompson LF, Craft MA, Mitchell DS, Shimasaki CD, Mulvihill JJ, Jupe ER. Oligogenic combinations associated with breast cancer risk in women under 53 years of age. Hum Genet 116:208-221, 2005. [Abstract]

Bruner BF, Wynn DM, Reichlin M, Harley JB, James JA. Humoral antigenic targets of the ribosomal P0 lupus autoantigen are not limited to the carboxyl region. Ann N Y Acad Sci 1051:390-403, 2005. [Abstract]

Dozmorov IM, Centola M, Knowlton N, Tang Y. Mobile classification in microarray experiments. Scand J Immunol 62 Suppl 1:84-91, 2005. [Abstract]

Hannan JP, Young KA, Guthridge JM, Asokan R, Szakonyi G, Chen XS, Holers VM. Mutational analysis of the complement receptor type 2 (CR2/CD21)-C3d interaction reveals a putative charged SCR1 binding site for C3d. J Mol Biol 346:845-858, 2005. [Abstract]

Huang H, Frank MB, Dozmorov I, Cao W, Cadwell C, Knowlton N, Centola M, Anderson RE. Identification of mouse retinal genes differentially regulated by dim and bright cyclic light rearing. Exp Eye Res 80:727-739, 2005. [Abstract]

Jarvis JN, Centola M. Gene-expression profiling: time for clinical application? Lancet 365:199-200, 2005. [Abstract]

Kim-Howard XR, Staudt L, James JA. Update in rheumatoid arthritis therapy. J Okla State Med Assoc 98:53-62, 2005. [Abstract]

Kochi Y, Yamada R, Suzuki A, Harley JB, Shirasawa S, Sawada T, Bae SC, Tokuhiro S, Chang X, Sekine A, Takahashi A, Tsunoda T, Ohnishi Y, Kaufman KM, Kang CP, Kang C, Otsubo S, Yumura W, Mimori A, Koike T, Nakamura Y, Sasazuki T, Yamamoto K. A functional variant in FCRL3, encoding Fc receptor-like 3, is associated with rheumatoid arthritis and several autoimmunities. Nat Genet 37:478-485, 2005. [Abstract]

Kurella S, Yaciuk JC, Dozmorov I, Frank MB, Centola M, Farris AD. Transcriptional modulation of TCR, Notch and Wnt signaling pathways in SEB-anergized CD4+ T cells. Genes Immun 6:596-608, 2005. [Abstract]

Kurien BT, Asfa S, Li C, Dorri Y, Jonsson R, Scofield RH. Induction of oral tolerance in experimental Sjogren’s syndrome autoimmunity. Scand J Immunol 61:418-425, 2005. [Abstract]

Kurien BT, Scofield RH. In vitro modification of solid phase multiple antigenic peptides/autoantigens with 4-hydroxy-2-nonenal (HNE) provide ideal substrates for detection of anti-HNE antibodies and peptide antioxidants. J Immunol Methods 303:66-75, 2005. [Abstract]

Kurien BT, Gross T, Scofield RH. Barbering in mice: a model for trichotillomania. BMJ 331:1503-1505, 2005. [Abstract]

Lee YH, Harley JB, Nath SK. CTLA-4 polymorphisms and systemic lupus erythematosus (SLE): a meta-analysis. Hum Genet 116:361-367, 2005. [Abstract]

McClain MT, Heinlen LD, Dennis GJ, Roebuck J, Harley JB, James JA. Early events in lupus humoral autoimmunity suggest initiation through molecular mimicry. Nat Med 11:85-89, 2005. [Abstract]

Miner J, Gillan MM, Alex P, Centola M. Steroid-refractory ulcerative colitis treated with corticosteroids, metronidazole and vancomycin: a case report. BMC Gastroenterol 5:3, 2005. [Abstract]

Namjou B, Kelly JA, Kilpatrick J, Kaufman KM, Nath SK, Scofield RH, Harley JB. Linkage at 5q14.3-15 in multiplex systemic lupus erythematosus pedigrees stratified by autoimmune thyroid disease. Arthritis Rheum 52:3646-3650, 2005. [Abstract]

Nath SK, Harley JB, Lee YH. Polymorphisms of complement receptor 1 and interleukin-10 genes and systemic lupus erythematosus: a meta-analysis. Hum Genet 118:225-234, 2005. [Abstract]

Naylor M. Imiquimod and superficial skin cancers. J Drugs Dermatol 4:598-606, 2005. [Abstract]

Nolsoe RL, Kelly JA, Pociot F, Moser KL, Kristiansen OP, Mandrup-Poulsen T, Harley JB. Functional promoter haplotypes of the human FAS gene are associated with the phenotype of SLE characterized by thrombocytopenia. Genes Immun 6:699-706, 2005. [Abstract]

Reichlin M. Serological correlations with nephritis in systemic lupus erythematosus. Clin Immunol 117:12-14, 2005. [Abstract]

* Rodgers W, Farris D, Mishra S. Merging complexes: properties of membrane raft assembly during lymphocyte signaling. Trends Immunol 26:97-103, 2005. [Abstract]

Sarkar K, Weinberg CR, Oddis CV, Medsger Jr TA, Plotz PH, Reveille JD, Arnett FC, Targoff IN, Genth E, Love LA, Miller FW. Seasonal influence on the onset of idiopathic inflammatory myopathies in serologically defined groups. Arthritis Rheum 52:2433-2438, 2005. [Abstract]

* Scofield RH, Kurien BT, Ganick S, McClain MT, Pye Q, James JA, Schneider RI, Broyles RH, Bachmann M, Hensley K. Modification of lupus-associated 60-kDa Ro protein with the lipid oxidation product 4-hydroxy-2-nonenal increases antigenicity and facilitates epitope spreading. Free Radic Biol Med 38:719-728, 2005. [Abstract]

Scofield RH, Asfa S, Obeso D, Jonsson R, Kurien BT. Immunization with short peptides from the 60-kDa Ro antigen recapitulates the serological and pathological findings as well as the salivary gland dysfunction of Sjogren’s syndrome. J Immunol 175:8409-8414, 2005. [Abstract]

Sestak AL, Nath SK, Harley JB. Genetics of systemic lupus erythematosus: how far have we come? Rheum Dis Clin North Am 31:223-244, 2005. [Abstract]

Szodoray P, Alex P, Jonsson MV, Knowlton N, Dozmorov I, Nakken B, Delaleu N, Jonsson R, Centola M. Distinct profiles of Sjogren’s syndrome patients with ectopic salivary gland germinal centers revealed by serum cytokines and BAFF. Clin Immunol 117:168-176, 2005. [Abstract]

Troyanov Y, Targoff IN, Tremblay JL, Goulet JR, Raymond Y, Senecal JL. Novel classification of idiopathic inflammatory myopathies based on overlap syndrome features and autoantibodies: analysis of 100 French Canadian patients. Medicine (Baltimore) 84:231-249, 2005. [Abstract]

Witchel SF, Kahsar-Miller M, Aston CE, White C, Azziz R. Prevalence of CYP21 mutations and IRS1 variant among women with polycystic ovary syndrome and adrenal androgen excess. Fertil Steril 83:371-375, 2005. [Abstract]

Wright H, Alex P, Nguyen T, Bader T, Gurakar A, Sebastian A, Gonzales L, Wallis G, Naylor M, Dozmorov I, Centola M, Nour B. Multiplex cytokine profiling of initial therapeutic response in patients with chronic hepatitis C virus infection. Dig Dis Sci 50:1793-1803, 2005. [Abstract]

Xing C, Gray-McGuire C, Kelly JA, Garriott P, Bukulmez H, Harley JB, Olson JM. Genetic linkage of systemic lupus erythematosus to 13q32 in African American families with affected male members. Hum Genet 118:309-321, 2005. [Abstract]

Yu X, Tang Y, Li F, Frank MB, Huang H, Dozmorov I, Zhu Y, Centola M, Cao W. Protection against hydrogen peroxide-induced cell death in cultured human retinal pigment epithelial cells by 17beta-estradiol: A differential gene expression profile. Mech Ageing Dev 126:1135-1145, 2005. [Abstract]

Zhang W, Reichlin M. Production and characterization of a human monoclonal anti-idiotype to anti-ribosomal P antibodies. Clin Immunol 114:130-136, 2005. [Abstract]

Zhang W, Reichlin M. A peptide DNA surrogate that binds and inhibits anti-dsDNA antibodies. Clin Immunol 117:214-220, 2005. [Abstract]

Cardiovascular Biology Research Program

Belczewski AR, Ho J, Taylor FB, Jr., Boffa MB, Jia Z, Koschinsky ML. Baboon lipoprotein(a) binds very weakly to lysine-agarose and fibrin despite the presence of a strong lysine-binding site in apolipoprotein(a) kringle IV type 10. Biochemistry 44:555-564, 2005. [Abstract]

Bochner BS, Alvarez RA, Mehta P, Bovin NV, Blixt O, White JR, Schnaar RL. Glycan array screening reveals a candidate ligand for Siglec-8. J Biol Chem 280:4307-4312, 2005. [Abstract]

Clayton F, Pysher TJ, Lou R, Kohan DE, Denkers ND, Tesh VL, Taylor FB, Jr., Siegler RL. Lipopolysaccharide upregulates renal shiga toxin receptors in a primate model of hemolytic uremic syndrome. Am J Nephrol 25:536-540, 2005. [Abstract]

Esmon C. Do-all receptor takes on coagulation, inflammation. Nat Med 11:475-477, 2005. [Abstract]

Esmon CT. Inflammation and coagulation. Hematology 10 Suppl 1:40, 2005.

Esmon CT. Is APC activation of endothelial cell PAR1 important in severe sepsis?: No. J Thromb Haemost 3:1910-1911, 2005. [Abstract]

Esmon CT. Coagulation inhibitors in inflammation. Biochem Soc Trans 33:401-405, 2005. [Abstract]

Esmon CT. The interactions between inflammation and coagulation. Br J Haematol 131:417-430, 2005. [Abstract]

Heymans S, Lupu F, Terclavers S, Vanwetswinkel B, Herbert JM, Baker A, Collen D, Carmeliet P, Moons L. Loss or inhibition of uPA or MMP-9 attenuates LV remodeling and dysfunction after acute pressure overload in mice. Am J Pathol 166:15-25, 2005. [Abstract]

Hinsdale ME, Maeda N. Complex control of mouse apolipoprotein B gene expression revealed by targeted duplication. Biochim Biophys Acta 1734:178-189, 2005. [Abstract]

Karmakar S, Cummings RD, McEver RP. Contributions of Ca2+ to galectin-1-induced exposure of phosphatidylserine on activated neutrophils. J Biol Chem 280:28623-28631, 2005. [Abstract]

Kinasewitz GT, Zein JG, Lee GL, Nazir SA, Taylor FB, Jr. Prognostic value of a simple evolving disseminated intravascular coagulation score in patients with severe sepsis. Crit Care Med 33:2214-2221, 2005. [Abstract]

Koeppe JR, Seitova A, Mather T, Komives EA. Thrombomodulin tightens the thrombin active site loops to promote protein C activation. Biochemistry 44:14784-14791, 2005. [Abstract]

Li W, Zheng X, Gu JM, Ferrell GL, Brady M, Esmon NL, Esmon CT. Extraembryonic expression of EPCR is essential for embryonic viability. Blood 106:2716-2722, 2005. [Abstract]

Li W, Zheng X, Gu J, Hunter J, Ferrell GL, Lupu F, Esmon NL, Esmon CT. Overexpressing endothelial cell protein C receptor alters the hemostatic balance and protects mice from endotoxin. J Thromb Haemost 3:1351-1359, 2005. [Abstract]

Ludeman MJ, Kataoka H, Srinivasan Y, Esmon N, Esmon CT, Coughlin SR. PAR1 cleavage and signaling in response to activated protein C and thrombin. J Biol Chem 280:13122-13128, 2005. [Abstract]

Lupu C, Hu X, Lupu F. Caveolin-1 enhances tissue factor pathway inhibitor exposure and function on the cell surface. J Biol Chem 280:22308-22317, 2005. [Abstract]

Lupu C, Westmuckett AD, Peer G, Ivanciu L, Zhu H, Taylor FB, Jr., Lupu F. Tissue factor-dependent coagulation is preferentially up-regulated within arterial branching areas in a baboon model of Escherichia coli sepsis. Am J Pathol 167:1161-1172, 2005. [Abstract]

Marshall BT, Sarangapani KK, Lou J, McEver RP, Zhu C. Force history dependence of receptor-ligand dissociation. Biophys J 88:1458-1466, 2005. [Abstract]

Marshall BT, Sarangapani KK, Wu J, Lawrence MB, McEver RP, Zhu C. Measuring molecular elasticity by atomic force microscope cantilever fluctuations. Biophys J 90:681-692, 2005. [Abstract]

Mazo IB, Honczarenko M, Leung H, Cavanagh LL, Bonasio R, Weninger W, Engelke K, Xia L, McEver RP, Koni PA, Silberstein LE, von Andrian UH. Bone marrow is a major reservoir and site of recruitment for central memory CD8(+) T cells. Immunity 22:259-270, 2005. [Abstract]

McEver RP. A sulfated address for lymphocyte homing. Nat Immunol 6:1067-1069, 2005. [Abstract]

Ny A, Koch M, Schneider M, Neven E, Tong RT, Maity S, Fischer C, Plaisance S, Lambrechts D, Heligon C, Terclavers S, Ciesiolka M, Kalin R, Man WY, Senn I, Wyns S, Lupu F, Brandli A, Vleminckx K, Collen D, Dewerchin M, Conway EM, Moons L, Jain RK, Carmeliet P. A genetic Xenopus laevis tadpole model to study lymphangiogenesis. Nat Med 11:998-1004, 2005. [Abstract]

Safa O, Esmon CT, Esmon NL. Inhibition of APC anticoagulant activity on oxidized phospholipid by anti-{beta}2-glycoprotein I monoclonal antibodies. Blood 106:1629-1635, 2005. [Abstract]

Sesin CA, Yin X, Esmon CT, Buyon JP, Clancy RM. Shedding of endothelial protein C receptor contributes to vasculopathy and renal injury in lupus: in vivo and in vitro evidence. Kidney Int 68:110-120, 2005. [Abstract]

Siegler RL, Pysher TJ, Tesh VL, Noris M, Cassis P, Taylor FB, Jr. Reduced nitric oxide bioavailability in a baboon model of Shiga toxin mediated hemolytic uremic syndrome (HUS). Ren Fail 27:635-641, 2005. [Abstract]

* Yao L, Yokota T, Xia L, Kincade PW, McEver RP. Bone marrow dysfunction in mice lacking the cytokine receptor gp130 in endothelial cells. Blood 106:4093-4101, 2005. [Abstract]

Zhu C, McEver RP. Catch bonds: physical models and biological functions. Mol Cell Biomech 2:91-104, 2005. [Abstract]

Zhu C, Lou J, McEver RP. Catch bonds: physical models, structural bases, biological function and rheological relevance. Biorheology 42:443-462, 2005. [Abstract]

Clinical Pharmacology Research Program

Binder SR, Genovese MC, Merrill JT, Morris RI, Metzger AL. Computer-assisted pattern recognition of autoantibody results. Clin Diagn Lab Immunol 12:1353-1357, 2005. [Abstract]

Buyon JP, Petri MA, Kim MY, Kalunian KC, Grossman J, Hahn BH, Merrill JT, Sammaritano L, Lockshin M, Alarcon GS, Manzi S, Belmont HM, Askanase AD, Sigler L, Dooley MA, Von Feldt J, McCune WJ, Friedman A, Wachs J, Cronin M, Hearth-Holmes M, Tan M, Licciardi F. The effect of combined estrogen and progesterone hormone replacement therapy on disease activity in systemic lupus erythematosus: a randomized trial. Ann Intern Med 142:953-962, 2005. [Abstract]

Ginzler EM, Dooley MA, Aranow C, Kim MY, Buyon J, Merrill JT, Petri M, Gilkeson GS, Wallace DJ, Weisman MH, Appel GB. Mycophenolate mofetil or intravenous cyclophosphamide for lupus nephritis. N Engl J Med 353:2219-2228, 2005. [Abstract]

Merrill JT, Buyon JP. The role of biomarkers in the assessment of lupus. Best Pract Res Clin Rheumatol 19:709-726, 2005. [Abstract]

Merrill JT. BLyS antagonists and peptide tolerance induction. Lupus 14:204-209, 2005. [Abstract]

Merrill JT. Emergence of targeted immune therapies for systemic lupus. Expert Opin Emerg Drugs 10:53-65, 2005. [Abstract]

Olech E, Merrill JT. DHEA supplementation: the claims in perspective. Cleve Clin J Med 72:965-966, 968, 970-1, 2005. [Abstract]

Petri M, Kim MY, Kalunian KC, Grossman J, Hahn BH, Sammaritano LR, Lockshin M, Merrill JT, Belmont HM, Askanase AD, McCune WJ, Hearth-Holmes M, Dooley MA, Von Feldt J, Friedman A, Tan M, Davis J, Cronin M, Diamond B, Mackay M, Sigler L, Fillius M, Rupel A, Licciardi F, Buyon JP. Combined oral contraceptives in women with systemic lupus erythematosus. N Engl J Med 353:2550-2558, 2005. [Abstract]

Crystallography Research Program

Zhu G, Zhai P, Wakeham N, He X, Zhang XC. Analysis of the interaction between GGA1 GAT domain and Rabaptin-5. Methods Enzymol 403:583-592, 2005. [Abstract]

Free Radical Biology and Aging Research Program

Bulteau AL, Lundberg KC, Ikeda-Saito M, Isaya G, Szweda LI. Reversible redox-dependent modulation of mitochondrial aconitase and proteolytic activity during in vivo cardiac ischemia/reperfusion. Proc Natl Acad Sci U S A 102:5987-5991, 2005. [Abstract]

Chaiswing L, Cole MP, Ittarat W, Szweda LI, St Clair DK, Oberley TD. Manganese superoxide dismutase and inducible nitric oxide synthase modify early oxidative events in acute adriamycin-induced mitochondrial toxicity. Mol Cancer Ther 4:1056-1064, 2005. [Abstract]

Churchill EN, Murriel CL, Chen CH, Mochly-Rosen D, Szweda LI. Reperfusion-induced translocation of deltaPKC to cardiac mitochondria prevents pyruvate dehydrogenase reactivation. Circ Res 97:78-85, 2005. [Abstract]

Churchill EN, Szweda LI. Translocation of deltaPKC to mitochondria during cardiac reperfusion enhances superoxide anion production and induces loss in mitochondrial function. Arch Biochem Biophys 439:194-199, 2005. [Abstract]

Guo WX, Pye QN, Williamson KS, Stewart CA, Hensley KL, Kotake Y, Floyd RA, Broyles RH. Mitochondrial dysfunction in choline deficiency-induced apoptosis in cultured rat hepatocytes. Free Radic Biol Med 39:641-650, 2005. [Abstract]

Hensley K, Williamson KS. HPLC-electrochemical detection of tocopherol products as indicators of reactive nitrogen intermediates. Methods Enzymol 396:171-182, 2005. [Abstract]

Hensley K, Floyd RA. Oxidative modification of proteins in cell signaling. Antioxid Redox Signal 7:523-525, 2005. [Abstract]

Ireland H, Konstantoulas CJ, Cooper JA, Hawe E, Humphries SE, Mather H, Goodall AH, Hogwood J, Juhan-Vague I, Yudkin JS, di Minno G, Margaglione M, Hamsten A, Miller GJ, Bauer KA, Kim YT, Stearns-Kurosawa DJ, Kurosawa S. EPCR Ser219Gly: Elevated sEPCR, prothrombin F1+2, risk for coronary heart disease, and increased sEPCR shedding in vitro. Atherosclerosis 183:283-292, 2005. [Abstract]

Kadiiska MB, Gladen BC, Baird DD, Germolec D, Graham LB, Parker CE, Nyska A, Wachsman JT, Ames BN, Basu S, Brot N, Fitzgerald GA, Floyd RA, George M, Heinecke JW, Hatch GE, Hensley K, Lawson JA, Marnett LJ, Morrow JD, Murray DM, Plastaras J, Roberts LJ, Rokach J, Shigenaga MK, Sohal RS, Sun J, Tice RR, Van Thiel DH, Wellner D, Walter PB, Tomer KB, Mason RP, Barrett JC. Biomarkers of Oxidative Stress Study II: are oxidation products of lipids, proteins, and DNA markers of CCl(4) poisoning? Free Radic Biol Med 38:698-710, 2005. [Abstract]

Kotake Y, Kishida H, Nakae D, Floyd RA. Nitric oxide production by primary liver cells isolated from amino Acid diet-fed rats. Methods Enzymol 396:535-541, 2005. [Abstract]

Papin JF, Floyd RA, Dittmer DP. Methylene blue photoinactivation abolishes West Nile virus infectivity in vivo. Antiviral Res 68:84-87, 2005. [Abstract]

Perluigi M, Fai PH, Hensley K, Pierce WM, Klein JB, Calabrese V, De Marco C, Butterfield DA. Proteomic analysis of 4-hydroxy-2-nonenal-modified proteins in G93A-SOD1 transgenic mice-A model of familial amyotrophic lateral sclerosis. Free Radic Biol Med 38:960-968, 2005. [Abstract]

Poon HF, Hensley K, Thongboonkerd V, Merchant ML, Lynn BC, Pierce WM, Klein JB, Calabrese V, Butterfield DA. Redox proteomics analysis of oxidatively modified proteins in G93A-SOD1 transgenic mice-a model of familial amyotrophic lateral sclerosis. Free Radic Biol Med 39:453-462, 2005. [Abstract]

Salsman SJ, Hensley K, Floyd RA. Sensitivity of protein tyrosine phosphatase activity to the redox environment, cytochrome C, and microperoxidase. Antioxid Redox Signal 7:1078-1088, 2005. [Abstract]

* Scofield RH, Kurien BT, Ganick S, McClain MT, Pye Q, James JA, Schneider RI, Broyles RH, Bachmann M, Hensley K. Modification of lupus-associated 60-kDa Ro protein with the lipid oxidation product 4-hydroxy-2-nonenal increases antigenicity and facilitates epitope spreading. Free Radic Biol Med 38:719-728, 2005. [Abstract]

Tanito M, Elliott MH, Kotake Y, Anderson RE. Protein modifications by 4-hydroxynonenal and 4-hydroxyhexenal in light-exposed rat retina. Invest Ophthalmol Vis Sci 46:3859-3868, 2005. [Abstract]

Tesiram YA, Saunders D, Towner RA. Application of proton NMR spectroscopy in the study of lipid metabolites in a rat hepatocarcinogenesis model. Biochim Biophys Acta 1737:61-68, 2005. [Abstract]

Tomita H, Kotake Y, Anderson RE. Mechanism of protection from light-induced retinal degeneration by the synthetic antioxidant phenyl-N-tert-butylnitrone. Invest Ophthalmol Vis Sci 46:427-434, 2005. [Abstract]

Towner RA, Foley LM, Painter DM. Hepatocarcinogenesis tumor grading correlated with in vivo image-guided (1)H-NMR spectroscopy in a rat model. Toxicol Appl Pharmacol 207:237-244, 2005. [Abstract]

Uematsu F, Takahashi M, Yoshida M, Igarashi M, Watanabe N, Suzuki N, Abe M, Rusyn I, Floyd RA, Nakae D. Distinct patterns of gene expression in hepatocellular carcinomas and adjacent non-cancerous, cirrhotic liver tissues in rats fed a choline-deficient, l-amino acid-defined diet. Cancer Sci 96:414-424, 2005. [Abstract]

Immunobiology and Cancer Research Program

* Aston CE, Ralph DA, Lalo DP, Manjeshwar S, Gramling BA, Defreese DC, West AD, Branam DE, Thompson LF, Craft MA, Mitchell DS, Shimasaki CD, Mulvihill JJ, Jupe ER. Oligogenic combinations associated with breast cancer risk in women under 53 years of age. Hum Genet 116:208-221, 2005. [Abstract]

Baba Y, Garrett KP, Kincade PW. Constitutively active beta-catenin confers multilineage differentiation potential on lymphoid and myeloid progenitors. Immunity 23:599-609, 2005. [Abstract]

Chain JL, Joachims ML, Hooker SW, Laurent AB, Knott-Craig CK, Thompson LF. Real-time PCR method for the quantitative analysis of human T-cell receptor gamma and beta gene rearrangements. J Immunol Methods 300:12-23, 2005. [Abstract]

Dudley DD, Chaudhuri J, Bassing CH, Alt FW. Mechanism and control of V(D)J recombination versus class switch recombination: Similarities and differences. Adv Immunol 86:43-112, 2005. [Abstract]

Huang J, Garrett KP, Pelayo R, Zuniga-Pflucker JC, Petrie HT, Kincade PW. Propensity of adult lymphoid progenitors to progress to DN2/3 stage thymocytes with notch receptor ligation. J Immunol 175:4858-4865, 2005. [Abstract]

Igarashi H, Medina KL, Yokota T, Rossi MI, Sakaguchi N, Comp PC, Kincade PW. Early lymphoid progenitors in mouse and man are highly sensitive to glucocorticoids. Int Immunol 17:501-511, 2005. [Abstract]

Maeda K, Baba Y, Nagai Y, Miyazaki K, Malykhin A, Nakamura K, Kincade PW, Sakaguchi N, Coggeshall KM. IL-6 blocks a discrete early step in lymphopoiesis. Blood 106:879-885, 2005. [Abstract]

Pelayo R, Welner R, Perry SS, Huang J, Baba Y, Yokota T, Kincade PW. Lymphoid progenitors and primary routes to becoming cells of the immune system. Curr Opin Immunol 17:100-107, 2005. [Abstract]

Pelayo R, Hirose J, Huang J, Garrett KP, Delogu A, Busslinger M, Kincade PW. Derivation of two categories of plasmacytoid dendritic cells in murine bone marrow. Blood 105:4407-4415, 2005. [Abstract]

Petrie HT, Kincade PW. Many roads, one destination for T cell progenitors. J Exp Med 202:11-13, 2005. [Abstract]

Rajaiya J, Hatfield M, Nixon JC, Rawlings DJ, Webb CF. Bruton’s Tyrosine Kinase regulates immunoglobulin promoter activation in association with the transcription factor Bright. Mol Cell Biol 25:2073-2084, 2005. [Abstract]

Schmittgen TD, Gissel KA, Zakrajsek BA, Lawrence BP, Liu Q, Jupe ER, Lerner MR, Do SV, Brackett DJ. Diverse gene expression pattern during 5-fluorouridine-induced apoptosis. Int J Oncol 27:297-306, 2005. [Abstract]

Vedham V, Phee H, Coggeshall KM. Vav activation and function as a rac Guanine nucleotide exchange factor in macrophage colony-stimulating factor-induced macrophage chemotaxis. Mol Cell Biol 25:4211-4220, 2005. [Abstract]

* Yao L, Yokota T, Xia L, Kincade PW, McEver RP. Bone marrow dysfunction in mice lacking the cytokine receptor gp130 in endothelial cells. Blood 106:4093-4101, 2005. [Abstract]

Lipid Studies

Blackett PR, Blevins KS, Stoddart M, Wang W, Quintana E, Alaupovic P, Lee ET. Body mass index and high-density lipoproteins in Cherokee Indian children and adolescents. Pediatr Res 58:472-477, 2005. [Abstract]

Blackett PR, Blevins KS, Quintana E, Stoddart M, Wang W, Alaupovic P, Lee ET. ApoC-III bound to apoB-containing lipoproteins increase with insulin resistance in Cherokee Indian youth. Metabolism 54:180-187, 2005. [Abstract]

Kwiterovich PO, Jr., Cockrill SL, Virgil DG, Garrett ES, Otvos J, Knight-Gibson C, Alaupovic P, Forte T, Zhang L, Farwig ZN, Macfarlane RD. A large high-density lipoprotein enriched in apolipoprotein C-I: a novel biochemical marker in infants of lower birth weight and younger gestational age. JAMA 293:1891-1899, 2005. [Abstract]

Wang W, Lee ET, Alaupovic P, Blackett P, Blevins KS. Correlation between lipoprotein(a) and other risk factors for cardiovascular disease and diabetes in Cherokee Indians: the Cherokee Diabetes Study. Ann Epidemiol 15:390-397, 2005. [Abstract]

Molecular, Cell and Developmental Biology Research Program

Ahonen LJ, Kallio MJ, Daum JR, Bolton M, Manke IA, Yaffe MB, Stukenberg PT, Gorbsky GJ. Polo-like Kinase 1 Creates the tension-sensing 3F3/2 phosphoepitope and modulates the association of spindle-checkpoint proteins at kinetochores. Curr Biol 15:1078-1089, 2005. [Abstract]

Conchello JA, Lichtman JW. Optical sectioning microscopy. Nat Methods 2:920-931, 2005. [Abstract]

Daehnel K, Harris R, Maddera L, Silverman P. Fluorescence assays for F-pili and their application. Microbiology 151:3541-3548, 2005. [Abstract]

Karpac J, Ostwald D, Bui S, Hunnewell P, Shankar M, Hochgeschwender U. Development, maintenance, and function of the adrenal gland in early postnatal Pro-opiomelanocortin Null mutant mice. Endocrinology 146:2555-2562, 2005. [Abstract]

Kateneva AV, Konovchenko AA, Guacci V, Dresser ME. Recombination protein Tid1p controls resolution of cohesin-dependent linkages in meiosis in Saccharomyces cerevisiae. J Cell Biol 171:241-253, 2005. [Abstract]

Lichtman JW, Conchello JA. Fluorescence microscopy. Nat Methods 2:910-919, 2005. [Abstract]

Lu H, Clarke M. Dynamic properties of Legionella-containing phagosomes in Dictyostelium amoebae. Cell Microbiol 7:995-1007, 2005. [Abstract]

Ren Q, Yang H, Rosinski M, Conrad MN, Dresser ME, Guacci V, Zhang Z. Mutation of the cohesin related gene PDS5 causes cell death with predominant apoptotic features in Saccharomyces cerevisiae during early meiosis. Mutat Res 570:163-173, 2005. [Abstract]

Reynolds NK, Schade MA, Miller KG. Convergent, RIC-8-dependent Galpha signaling pathways in the Caenorhabditis elegans synaptic signaling network. Genetics 169:651-670, 2005. [Abstract]

Schade MA, Reynolds NK, Dollins CM, Miller KG. Mutations that rescue the paralysis of C. elegans ric-8 (Synembryn) mutants activate the G{alpha}s Pathway and define a third major branch of the synaptic signaling network. Genetics 169:631-649, 2005. [Abstract]

Zhang Z, Ren Q, Yang H, Conrad MN, Guacci V, Kateneva A, Dresser ME. Budding yeast PDS5 plays an important role in meiosis and is required for sister chromatid cohesion. Mol Microbiol 56:670-680, 2005. [Abstract]

Molecular Immunogenetics Research Program

Byrum J, Rodgers W. Visualization of transfer of a fluorescently-labeled membrane raft protein to T cells using lentivirus. Gene Ther Mol Biol 9B:135-142, 2005. [Abstract]

Jackson SM, Capra JD. IgH V-Region sequence does not predict the survival fate of human germinal center B cells. J Immunol 174:2805-2813, 2005. [Abstract]

Rodgers W, Smith K. Properties of glycolipid-enriched membrane rafts in antigen presentation. Crit Rev Immunol 25:19-30, 2005. [Abstract]

* Rodgers W, Farris D, Mishra S. Merging complexes: properties of membrane raft assembly during lymphocyte signaling. Trends Immunol 26:97-103, 2005. [Abstract]

Zheng NY, Wilson K, Jared M, Wilson PC. Intricate targeting of immunoglobulin somatic hypermutation maximizes the efficiency of affinity maturation. J Exp Med 201:1467-1478, 2005. [Abstract]

Protein Studies Research Program

Chang WP, Combs GF, Jr., Scanes CG, Marsh JA. The effects of dietary vitamin E and selenium deficiencies on plasma thyroid and thymic hormone concentrations in the chicken. Dev Comp Immunol 29:265-273, 2005. [Abstract]

Ghosh AK, Kumaragurubaran N, Tang J. Recent developments of structure based beta-secretase inhibitors for Alzheimer’s disease. Curr Top Med Chem 5:1609-1622, 2005. [Abstract]

Ghosh AK, Devasamudram T, Hong L, Dezutter C, Xu X, Weerasena V, Koelsch G, Bilcer G, Tang J. Structure-based design of cycloamide-urethane-derived novel inhibitors of human brain memapsin 2 (beta-secretase). Bioorg Med Chem Lett 15:15-20, 2005. [Abstract]

He X, Li F, Chang W, Tang J. GGA proteins mediate the recycling pathway of memapsin 2 (BACE). J Biol Chem 280:11696-11703, 2005. [Abstract]

Tang J, He X, Huang X, Hong L. Recent developments on the studies of human memapsin 2 (beta-secretase). Curr Alzheimer Res 2:261-264, 2005. [Abstract]

Turner RT, III, Hong L, Koelsch G, Ghosh AK, Tang J. Structural locations and functional roles of new subsites S5, S6, and S7 in memapsin 2 (beta-secretase). Biochemistry 44:105-112, 2005. [Abstract]

* Indicates publications by more than one department.

01/13/10