2001 Scientific Publications
Arthritis and Immunology Research Program
Alberdi,F., J.Dadone, A.Ryazanov, D.A.Isenberg, and M.Reichlin. 2001. Cross-reaction of lupus anti-dsDNA antibodies with protein translation factor EF-2. Clin.Immunol. 98:293-300.
Anderson,C.J., B.R.Neas, T.Uchiumi, and H.A.Stafford. 2001. Autoantibodies to the 20-kDa ribosomal proteins: Identification, characterization, and new aspects on prevalence in systemic lupus erythematosus. Clin.Immunol. 98:249-257.
Arbuckle,M.R., J.A.James, K.F.Kohlhase, M.V.Rubertone, G.J.Dennis, and J.B.Harley. 2001. Development of anti-dsDNA autoantibodies prior to clinical diagnosis of systemic lupus erythematosus. Scand.J Immunol. 54:211-219.
Guthridge,J.M., K.Young, M.G.Gipson, M.R.Sarrias, G.Szakonyi, X.S.Chen, A.Malaspina, E.Donoghue, J.A.James, J.D.Lambris, S.A.Moir, S.J.Perkins, and V.M.Holers. 2001. Epitope mapping using the X-ray crystallographic structure of complement receptor type 2 (CR2)/CD21: identification of a highly inhibitory monoclonal antibody that directly recognizes the CR2-C3d interface. J Immunol. 167:5758-5766.
Howell,P., S.Kariampuzha, W.Kipgen, M.Z.Baker, T.L.Tytle, G.R.Williams, and R.H.Scofield. 2001. Non-surgical therapy of primary hyperparathyroidism. J Okla.State Med Assoc. 94:561-565.
James,J.A., J.B.Harley, and R.H.Scofield. 2001. Role of viruses in systemic lupus erythematosus and Sjogren syndrome. Curr.Opin.Rheumatol. 13:370-376.
James,J.A., B.R.Neas, K.L.Moser, T.Hall, G.R.Bruner, A.L.Sestak, and J.B.Harley. 2001. Systemic lupus erythematosus in adults is associated with previous Epstein-Barr virus exposure. Arthritis Rheum. 44:1122-1126.
* Jupe,E.R., A.A.Badgett, B.R.Neas, M.A.Craft, D.S.Mitchell, R.Resta, J.J.Mulvihill, C.E.Aston, and L.F.Thompson. 2001. Single nucleotide polymorphism in prohibitin 39 untranslated region and breast-cancer susceptibility. Lancet 357:1588-1589.
Kaufman,K.M., J.Kelly, C.Gray-McGuire, N.Asundi, H.Yu, J.Reid, T.Baird, D.Hutchings, G.Bruner, R.H.Scofield, K.Moser, and J.B.Harley. 2001. Linkage analysis of angiotensin-converting enzyme (ACE) insertion/deletion polymorphism and systemic lupus erythematosus. Mol.Cell Endocrinol. 177:81-85.
Kaufman,K.M., M.Y.Kirby, M.T.McClain, J.B.Harley, and J.A.James. 2001. Lupus autoantibodies recognize the product of an alternative open reading frame of SmB/B’. Biochem.Biophys.Res.Commun. 285:1206-1212.
Kurien,B.T., T.L.Chambers, P.Y.Thomas, M.B.Frank, and R.H.Scofield. 2001. Autoantibody to the leucine zipper region of 52 kDa Ro/SSA binds native 60 kDa Ro/SSA: identification of a tertiary epitope with components from 60 kDa Ro/SSA and 52 kDa Ro/SSA. Scand.J.Immunol. 53:268-276.
Kurien,B.T., K.M.Kaufman, J.B.Harley, and R.H.Scofield. 2001. Pellet pestle homogenization of agarose gel slices at 45 degrees C for deoxyribonucleic acid extraction. Anal.Biochem. 296:162-166.
Kurien,B.T., H.Matsumoto, and R.H.Scofield. 2001. Purification of tryptic peptides for mass spectrometry using polyvinylidene fluoride membrane. Indian J.Biochem.Biophys. 38:274-276.
McClain,M.T., J.B.Harley, and J.A.James. 2001. The role of Epstein-Barr virus in systemic lupus erythematosus. Front Biosci. 6:E137-E147.
Najafi,C.C., S.M.Korbet, E.J.Lewis, M.M.Schwartz, M.Reichlin, and J.Evans. 2001. Significance of histologic patterns of glomerular injury upon long-term prognosis in severe lupus glomerulonephritis. Kidney Int. 59:2156-2163.
Nath,S.K., C.H.Chen, and N.J.Schork. 2001. Two-trait-locus linkage anayses of asthma susceptibility. Genet.Epidemiol. 21:S278-S283.
Nath,S.K., J.A.Kelly, B.Namjou, T.Lam, G.R.Bruner, R.H.Scofield, C.E.Aston, and J.B.Harley. 2001. Evidence for a susceptibility gene, SLEV1, on chromosome 17p13 in families with vitiligo-related systemic lupus erythematosus. Am.J Hum.Genet. 69: 1401-1406.
Njoroge,J.M., L.B.Mitchell, M.Centola, D.Kastner, M.Raffeld, and J.L.Miller. 2001. Characterization of viable autofluorescent macrophages among cultured peripheral blood mononuclear cells. Cytometry 44:38-44.
Pan,Z.J., C.J.Anderson, and H.A.Stafford. 2001. A murine monoclonal anti-idiotype to anti-ribosomal P antibodies: production, characterization, and use in systemic lupus erythematosus. Clin.Immunol. 100:289-297.
Quintero-Del-Rio,A.I., D.Bacino, J.Kelly, T.Aberle, and J.B.Harley. 2001. Familial systemic lupus erythematosus: a comparison of clinical manifestations and antibody presentation in three ethnic groups. Cell Mol.Biol (Noisy.-le-grand) 47:1223-1227.
Rao,S., J.M.Olson, K.L.Moser, C.Gray-McGuire, G.R.Bruner, J.Kelly, and J.B.Harley. 2001. Linkage analysis of human systemic lupus erythematosus-related traits: a principal component approach. Arthritis Rheum. 44:2807-2818.
Scofield,A.N., B.T.Kurien, T.P.Gordon, and R.H.Scofield. 2001. Can B cell epitopes of 60 kDa Ro distinguish systemic lupus erythematosus from Sjogren’s syndrome? Lupus 10:547-553.
Stafford,H.A., Z.J.Pan, and C.J.Anderson. 2001. Possible role of antiidiotypes in the loss of anti-topoisomerase I antibodies: comment on the article by Kuwana et al. Arthritis Rheum. 44:737-738.
Takeda,I., K.Rayno, F.B.Movafagh, M.Wolfson-Reichlin, and M.Reichlin. 2001. Dual binding capabilities of anti-double-stranded DNA antibodies and anti-ribosomal phosphoprotein (P) antibodies. Lupus 10:857-865.
Zhang,W., T.Winkler, J.R.Kalden, and M.Reichlin. 2001. Isolation of human anti-idiotypes broadly cross reactive with anti-dsDNA antibodies from patients with systemic lupus erythematosus. Scand.J.Immunol. 53:192-197.
Cardiovascular Biology Research Program
Alberio,L., B.Lammle, and C.T.Esmon. 2001. Protein C replacement in severe meningococcemia: rationale and clinical experience. Clin.Infect.Dis. 32:1338-1346.
Bernard,G., A.Artigas, P.Dellinger, C.Esmon, E.Faist, S.N.Faust, C.J.Fischer, R.Fumagalli, B.W.Grinnell, and C.Sprung. 2001. Clinical expert round table discussion (session 3) at the Margaux Conference on Critical Illness: the role of activated protein C in severe sepsis. Crit Care Med 29:S75-S77.
Biguzzi,E., G.Merati, P.C.Liaw, P.Bucciarelli, N.Oganesyan, D.Qu, J.M.Gu, R.Fetiveau, C.T.Esmon, P.M.Mannucci, and E.M.Faioni. 2001. A 23bp insertion in the endothelial protein C receptor (EPCR) gene impairs EPCR function. Thromb.Haemost. 86:945-948.
Carlet,J., F.Taylor, M.Levi, A.Artigas, H.ten Cate, and J.Marshall. 2001. Clinical expert round table discussion (session 4) at the Margaux Conference on Critical Illness: sepsis: inflammation disorder, coagulation disorder, or both? A challenge for clinicians. Crit Care Med 29:S107-S108.
Comp,P.C., T.E.Spiro, R.J.Friedman, T.L.Whitsett, G.J.Johnson, G.A.Gardiner, Jr., G.C.Landon, and M.Jove. 2001. Prolonged enoxaparin therapy to prevent venous thromboembolism after primary hip or knee replacement. Enoxaparin Clinical Trial Group. J.Bone Joint Surg.Am. 83-A:336-345.
Daugherty,B.L., K.S.Straley, J.M.Sanders, J.W.Phillips, M.Disdier, R.P.McEver, and S.A.Green. 2001. AP-3 adaptor functions in targeting P-selectin to secretory granules in endothelial cells. Traffic. 2:406-413.
Esmon,C.T. 2001. A myriad of responses. Lancet 358 Suppl:61.:S61.
Esmon,C.T. 2001. The normal role of Activated Protein C in maintaining homeostasis and its relevance to critical illness. Crit Care 5:S7-S12.
Esmon,C.T. 2001. Plasma glycolipids levels: new factors regulating the protein C anticoagulant pathway and determining thrombotic risk. Blood 97:1905.
Esmon,C.T. 2001. Protein C anticoagulant pathway and its role in controlling microvascular thrombosis and inflammation. Crit Care Med 29:S48-S52.
Esmon,C.T. 2001. Role of coagulation inhibitors in inflammation. Thromb.Haemost. 86:51-56.
Faust,S.N., M.Levin, O.B.Harrison, R.D.Goldin, M.S.Lockhart, S.Kondaveeti, Z.Laszik, C.T.Esmon, and R.S.Heyderman. 2001. Dysfunction of endothelial protein C activation in severe meningococcal sepsis. N.Engl.J Med 345:408-416.
* Igarashi,H., T.Kouro, T.Yokota, P.C.Comp, and P.W.Kincade. 2001. Age and stage dependency of estrogen receptor expression by lymphocyte precursors. Proc.Natl.Acad.Sci U.S.A 98:15131-15136.
Laszik,Z.G., X.J.Zhou, G.L.Ferrell, F.G.Silva, and C.T.Esmon. 2001. Down-regulation of endothelial expression of endothelial cell protein C receptor and thrombomodulin in coronary atherosclerosis. Am.J Pathol.159:797-802.
Li,A., A.C.Chang, G.T.Peer, T.C.Wun, and F.B.Taylor, Jr. 2001. Recombinant tissue factor pathway inhibitor enhances the binding of factor Xa to human monocytes. Thromb.Haemost. 85:830-836.
Liaw,P.C., T.Mather, N.Oganesyan, G.L.Ferrell, and C.T.Esmon. 2001. Identification of the protein C/activated protein C binding sites on the endothelial cell protein C receptor: implications for a novel mode of ligand recognition by a major histocompatibility complex class 1-type receptor. J. Biol. Chem. 276: 8364-8370
McEver,R.P. 2001. Adhesive interactions of leukocytes, platelets, and the vessel wall during hemostasis and inflammation. Thromb.Haemost. 86:746-756.
Owen,D.J., H.Setiadi, P.R.Evans, R.P.McEver, and S.A.Green. 2001. A third specificity-determining site in mu 2 adaptin for sequences upstream of Yxx phi sorting motifs. Traffic. 2:105-110.
Ramachandran,V., T.Yago, T.K.Epperson, M.M.Kobzdej, M.U.Nollert, R.D.Cummings, C.Zhu, and R.P.McEver. 2001. From the Cover: dimerization of a selectin and its ligand stabilizes cell rolling and enhances tether strength in shear flow. Proc.Natl.Acad.Sci U.S.A. 98:10166-10171.
* Rossi,M.I., K.L.Medina, K.Garrett, G.Kolar, P.C.Comp, L.D.Shultz, J.D.Capra, P.Wilson, A.Schipul, and P.W.Kincade. 2001. Relatively normal human lymphopoiesis but rapid turnover of newly formed B cells in transplanted nonobese diabetic/SCID mice. J Immunol. 167:3033-3042.
Rudnicka,A.R., G.J.Miller, T.Nelson, D.Doray, and P.C.Comp. 2001. An association between plasma free protein s concentration and risk of coronary heart disease in middle-aged men. Thromb.Res. 101:1-11.
* Safa,O., K.Hensley, M.D.Smirnov, C.T.Esmon, and N.L.Esmon. 2001. Lipid oxidation enhances the function of activated protein C. J.Biol.Chem. 2001 276:1829-36.
Siegler,R.L., T.J.Pysher, R.Lou, V.L.Tesh, and F.B.Taylor, Jr. 2001. Response to Shiga toxin-1, with and without lipopolysaccharide, in a primate model of hemolytic uremic syndrome. Am.J Nephrol. 21:420-425.
Siegler,R.L., T.J.Pysher, V.L.Tesh, and F.B.Taylor, Jr. 2001. Response to single and divided doses of Shiga toxin-1 in a primate model of hemolytic uremic syndrome. J Am.Soc.Nephrol. 12:1458-1467.
Silence,J., F.Lupu, D.Collen, and H.R.Lijnen. 2001. Persistence of atherosclerotic plaque but reduced aneurysm formation in mice with stromelysin-1 (MMP-3) gene inactivation. Arterioscler.Thromb.Vasc.Biol 21:1440-1445.
Taylor,F.B.Jr., G.T.Peer, M.S.Lockhart, G.Ferrell, and C.T.Esmon. 2001. Endothelial cell protein C receptor plays an important role in protein C activation in vivo. Blood 97:1685-1688.
Taylor,F.B.,Jr, 2001. Response of anticoagulant pathways in disseminated intravascular coagulation. Semin.Thromb.Hemost. 27:619-632.
Taylor,F.B., Jr. 2001. Staging of the pathophysiologic responses of the primate microvasculature to Escherichia coli and endotoxin: examination of the elements of the compensated response and their links to the corresponding uncompensated lethal variants. Crit Care Med 29:S78-S89.
Taylor,F.B., Jr., C.H.Toh, W.K.Hoots, H.Wada, and M.Levi. 2001. Towards definition, clinical and laboratory criteria, and a scoring system for disseminated intravascular coagulation. Thromb.Haemost. 86:1327-1330.
Taylor,F.B., P.A.Haddad, E.Hack, A.C.Chang, G.T.Peer, J.H.Morrissey, A.Li, R.C.Allen, H.Wada, and G.T.Kinasewitz. 2001. Two-stage response to endotoxin infusion into normal human subjects: correlation of blood phagocyte luminescence with clinical and laboratory markers of the inflammatory, hemostatic response. Crit Care Med. 29:326-334.
Wada,H., M.Yamamuro, A.Inoue, H.Shiku, N.Sakuragawa, H.Redl, G.Peer, and F.B.Taylor, Jr. 2001. Comparison of the responses of global tests of coagulation with molecular markers of neutrophil, endothelial, and hemostatic system perturbation in the baboon model of E. colisepsis–toward a distinction between uncompensated overt DIC and compensated non-overt DIC. Thromb.Haemost. 86:1489-1494.
Wang,S.X., C.T.Esmon, and R.J.Fletterick. 2001. Crystal structure of thrombin-ecotin reveals conformational changes and extended interactions. Biochemistry 40:10038-10046.
Westmuckett,A.D., V.V.Kakkar, T.Hamuro, F.Lupu, and C.Lupu. 2001. Bemiparin and fluid flow modulate the expression, activity and release of tissue factor pathway inhibitor in human endothelial cells in vitro. Thromb.Haemost. 86:1547-1554.
Wu,J.S., J.M.Gu, J.Xu, J.Wang, Z.M.Sun, M.D.Smirnov, J.H.Morrissey, and N.Esmon. 2001. Factor V Leiden mutation in one family of Chinese origin. Chin.Med.J. 114:379-381.
Clinical Pharmacology Research Program
* Manion,C.V., J.Howard, B.Ogle, J.Parkhurst, and A.B.Edmundson. 2001. Aspartame effect in sickle cell anemia. Clin.Pharmacol.Ther. 69:346-355.
Comparative Medicine
Gruber,H.E., T.L.Johnson, J.M.Kinsella, E.C.Greiner, and B.E.Gordon. 2001. Tapeworm identification in the fat sand rat (Psammomys obesus obesus). Contemp.Top.Lab Anim Sci 40:22-24.
Gruber,H.E., I.J.Puzanov, M.Bennett, V.Kumar, V, and B.Gordon. 2001. Alterations in osteoclast morphology following long-term 17 beta-estradiol administration in the mouse. BMC.Cell Biol. 2:3.
Crystallography Research Program
Altuve,A., S.Silchenko, K.H.Lee, K.Kuczera, S.Terzyan, X.Zhang, D.R.Benson, and M.Rivera. 2001. Probing the differences between rat liver outer mitochondrial membrane cytochrome b5 and microsomal cytochromes b5. Biochemistry 40:9469-9483.
Alvarado,U.R., C.R.Dewitt, B.B.Shultz, P.A.Ramsland, and A.B.Edmundson. 2001. Crystallization of a human Bence-Jones protein in microgravity using vapor diffusion in capillaries. J.Cryst.Growth. 223:407-414.
Edmundson,A.B., G.Tribbick, S.Plompen, H.M.Geysen, E.Yuriev, and P.A.Ramsland. 2001. Binding of synthetic peptides by a human monoclonal IgM with an unusual combining site structure. J Mol.Recognit. 14:229-238.
* Loy,J.A., X.Lin, M.Schenone, F.J.Castellino, X.C.Zhang, and J.Tang. 2001. Domain Interactions between streptokinase and human plasminogen. Biochemistry 40:14686-14695.
* Manion,C.V., J.Howard, B.Ogle, J.Parkhurst, and A.B.Edmundson. 2001. Aspartame effect in sickle cell anemia. Clin.Pharmacol.Ther. 69:346-355.
Marchalonis,J.J., M.K.Adelman, I.F.Robey, S.F.Schluter, and A.B.Edmundson. 2001. Exquisite specificity and peptide epitope recognition promiscuity, properties shared by antibodies from sharks to humans. J.Mol.Recognit. 14:110-121.
Marchalonis,J.J., I.F.Robey, A.B.Edmundson, R.T.Sepulveda, and R.R.Watson. 2001. T-cell receptor-derived peptides in immunoregulation and therapy of retrovirally induced immunosuppression. Crit Rev.Immunol. 21:57-74.
Ramsland,P.A., A.Kaushik, J.J.Marchalonis, and A.B.Edmundson. 2001. Incorporation of Long CDR3s into V Domains: Implications for the Structural Evolution of the Antibody-Combining Site. Exp.Clin.Immunogenet. 18:176-198.
Ramsland,P.A., J.L.Upshaw, B.B.Shultz, C.R.Dewitt, W.F.Chissoe, R.L.Raison, and A.B.Edmundson. 2001. Interconversion of different crystal forms of Fabs from human IgM cryoglobulins. J.Cryst.Growth. 232:204-214.
Ramsland,P.A., E.Yuriev, and A.B.Edmundson. 2001. Immunoglobulin cross-reactivity examined by library screening, crystallography and docking studies. Comb.Chem.High Throughput.Screen. 4:397-408.
Yuriev,E., P.A.Ramsland, and A.B.Edmundson. 2001. Docking of combinatorial peptide libraries into a broadly cross-reactive human IgM. J Mol.Recognit. 14:172-184.
Developmental Biology Research Program
Forbes,S., S.Bui, B.R.Robinson, U.Hochgeschwender, and M.B.Brennan. 2001. Integrated control of appetite and fat metabolism by the leptin-proopiomelanocortin pathway. Proc.Natl.Acad.Sci.U.S.A 98:4233-4237.
Hirasawa,M., A.Cho, T.Sreenath, B.Sauer, J.P.Julien, and A.B.Kulkarni. 2001. Neuron-specific expression of Cre recombinase during the late phase of brain development. Neurosci.Res. 40:125-132.
Le,Y. and B.Sauer. 2001. Conditional gene knockout using Cre recombinase. Mol.Biotechnol. 17:269-275.
Sharifi,N., N.Diehl, L.Yaswen, M.B.Brennan, and U.Hochgeschwender. 2001. Generation of dynorphin knockout mice. Brain Res.Mol.Brain Res. 86:70-75.
Wang,Z., L.R.Gardell, M.H.Ossipov, T.W.Vanderah, M.B.Brennan, U.Hochgeschwender, V.J.Hruby, T.P.Malan, J.Lai, and F.Porreca. 2001. Pronociceptive actions of dynorphin maintain chronic neuropathic pain. J.Neurosci. 21:1779-1786.
Zeyda,T., N.Diehl, R.Paylor, M.B.Brennan, and U.Hochgeschwender. 2001. Impairment in motor learning of somatostatin null mutant mice. Brain Res. 906:107-114.
Functional Proteomics Laboratory
Wei,X.C., X.J.Wang, K.Chen, L.Zhang, Y.Liang, and X.L.Lin. 2001. Killing effect of TNF-related apoptosis inducing ligand regulated by tetracycline on gastric cancer cell line NCI-N87. World J.Gastroenterol. 7:559-562.
Free Radical Biology and Aging Research Program
Broyles,R.H., V.Belegu, C.R.Dewitt, S.N.Shah, C.A.Stewart, Q.N.Pye, and R.A.Floyd. 2001. Specific repression of beta-globin promoter activity by nuclear ferritin. Proc.Natl.Acad.Sci U.S.A 98:9145-9150.
Endoh,H., N.Kato, S.Fujii, Y.Suzuki, S.Sato, T.Kayama, Y.Kotake, and T.Yoshimura. 2001. Spin trapping agent, phenyl N-tert-butylnitrone, reduces nitric oxide production in the rat brain during experimental meningitis. Free Radic.Res. 35:583-591.
Floyd,R.A., M.West, and K.Hensley. 2001. Oxidative biochemical markers; clues to understanding aging in long-lived species. Exp.Gerontol. 36:619-640.
Huycke,M.M., D.Moore, W.Joyce, P.Wise, L.Shepard, Y.Kotake, and M.S.Gilmore. 2001. Extracellular superoxide production by Enterococcus faecalis requires demethylmenaquinone and is attenuated by functional terminal quinol oxidases. Mol.Microbiol. 42:729-740.
Nakagawa,H., N.Ikota, T.Ozawa, and Y.Kotake. 2001. Dose- and time-dependence of radiation-induced nitric oxide formation in mice as quantified with electron paramagnetic resonance. Nitric.Oxide. 5:47-52.
* Safa,O., K.Hensley, M.D.Smirnov, C.T.Esmon, and N.L.Esmon. 2001. Lipid oxidation enhances the function of activated protein C. J.Biol.Chem. 2001 276:1829-36.
Salsman,S., N.Felts, Q.N.Pye, R.A.Floyd, and K.Hensley. 2001. Induction of Akt phosphorylation in rat primary astrocytes by H2O2 occurs upstream of phosphatidylinositol 3-kinase: no evidence for oxidative inhibition of PTEN. Arch.Biochem.Biophys. 386:275-280.
Tabatabaie,T., A.M.Vasquez, D.R.Moore, R.A.Floyd, and Y.Kotake. 2001. Direct administration of interleukin-1 and interferon-gamma to rat pancreas leads to the in vivo production of nitric oxide and expression of inducible nitric oxide synthase and inducible cyclooxygenase. Pancreas 23:316-322.
Weindruch,R., K.P.Keenan, J.M.Carney, G.Fernandes, R.J.Feuers, R.A.Floyd, J.B.Halter, J.J.Ramsey, A.Richardson, and G.S.Roth. 2001. Caloric restriction mimetics: metabolic interventions. J.Gerontol.A.Biol.Sci.Med.Sci. 56:20-33.
Immunobiology and Cancer Research Program
Alcorn,M.J., J.L.Booth, K.M.Coggeshall, and J.P.Metcalf. 2001. Adenovirus type 7 induces interleukin-8 production via activation of extracellular regulated kinase 1/2. J Virol. 75:6450-6459.
Cooney,D.S., H.Phee, A.Jacob, and K.M.Coggeshall. 2001. Signal transduction by human-restricted fcgammariia involves three distinct cytoplasmic kinase families leading to phagocytosis. J Immunol. 167:844-854.
Garrison,H.H. and P.W.Kincade. 2001. Careers in immunology: the new reality. Nat.Immunol. 2:5-8.
* Igarashi,H., T.Kouro, T.Yokota, P.C.Comp, and P.W.Kincade. 2001. Age and stage dependency of estrogen receptor expression by lymphocyte precursors. Proc.Natl.Acad.Sci U.S.A 98:15131-15136.
Isenberg,J.S. 2001. Additional follow-up with microvascular transfer in the treatment of chronic venous stasis ulcers. J Reconstr.Microsurg. 17:603-605.
* Jupe,E.R., A.A.Badgett, B.R.Neas, M.A.Craft, D.S.Mitchell, R.Resta, J.J.Mulvihill, C.E.Aston, and L.F.Thompson. 2001. Single nucleotide polymorphism in prohibitin 39 untranslated region and breast-cancer susceptibility. Lancet 357:1588-1589.
Kouro,T., K.L.Medina, K.Oritani, and P.W.Kincade. 2001. Characteristics of early murine B-lymphocyte precursors and their direct sensitivity to negative regulators. Blood 97:2708-2715.
Medina,K.L., K.P.Garrett, L.F.Thompson, M.I.Rossi, K.J.Payne, and P.W.Kincade. 2001. Identification of very early lymphoid precursors in bone marrow and their regulation by estrogen. Nat.Immunol. 2:718-724.
Miyoshi,E.K., P.L.Stewart, P.W.Kincade, M.B.Lee, A.A.Thompson, and R.Wall. 2001. Aberrant expression and localization of the cytoskeleton-binding pp52 (LSP1) protein in hairy cell leukemia. Leuk.Res. 25:57-67.
Oritani,K., P.W.Kincade, and Y.Tomiyama. 2001. Limitin: an interferon-like cytokine without myeloerythroid suppressive properties. J Mol.Med 79:168-174.
Oritani,K., P.W.Kincade, C.Zhang, Y.Tomiyama, and Y.Matsuzawa. 2001. Type I interferons and limitin: a comparison of structures, receptors, and functions. Cytokine Growth Factor Rev. 12:337-348.
* Phee,H., W.Rodgers, and K.M.Coggeshall. 2001. Visualization of negative signaling in B cells by quantitative confocal microscopy. Mol.Cell Biol 21:8615-8625.
* Rossi,M.I., K.L.Medina, K.Garrett, G.Kolar, P.C.Comp, L.D.Shultz, J.D.Capra, P.Wilson, A.Schipul, and P.W.Kincade. 2001. Relatively normal human lymphopoiesis but rapid turnover of newly formed B cells in transplanted nonobese diabetic/SCID mice. J Immunol.167:3033-3042.
Watanabe,Y., M.Hashizume, S.Kataoka, E.Hamaguchi, N.Morimoto, S.Tsuru, S.Katoh, K.Miyake, K.Matsushima, M.Tominaga, T.Kurashige, S.Fujimoto, P.W.Kincade, and A.Tominaga. 2001. Differentiation stages of eosinophils characterized by hyaluronic acid binding via CD44 and responsiveness to stimuli. DNA Cell Biol 20:189-202.
Webb,C.F. 2001. The transcription factor, Bright, and immunoglobulin heavy chain expression. Immunol.Res. 24:149-161.
Lipid Studies Laboratory
Brown,B.G., X.Q.Zhao, A.Chait, L.D.Fisher, M.C.Cheung, J.S.Morse, A.A.Dowdy, E.K.Marino, E.L.Bolson, P.Alaupovic, J.Frohlich, and J.J.Albers. 2001. Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease. N.Engl.J Med 345:1583-1592.
Grassmann,J., D.Schneider, D.Weiser, and E.F.Elstner. 2001. Antioxidative effects of lemon oil and its components on copper induced oxidation of low density lipoprotein. Arzneimittelforschung. 51:799-805.
Ottosson,P., P.O.Attman, C.Knight, O.Samuelsson, L.Weiss, and P.Alaupovic. 2001. Do high-flux dialysis membranes affect renal dyslipidemia? ASAIO J. 47:229-234.
Molecular Cell Biology Research Program
Barstead,R. 2001. Genome-wide RNAi. Curr.Opin.Chem.Biol. 5:63-66.
Duerr,J.S., J.Gaskin, and J.B.Rand. 2001. Identified neurons in C. elegans coexpress vesicular transporters for acetylcholine and monoamines. Am.J.Physiol Cell Physiol 280:C1616-C1622.
Dvir,A., J.W.Conaway, and R.C.Conaway. 2001. Mechanism of transcription initiation and promoter escape by RNA polymerase II. Curr.Opin.Genet.Dev. 11:209-214.
Elmendorf,B.J., A.Shilatifard, Q.Yan, J.W.Conaway, and R.C.Conaway. 2001. Transcription factors TFIIF, ELL, and Elongin negatively regulate SII-induced nascent transcript cleavage by non-arrested RNA polymerase II elongation intermediates. J.Biol.Chem. 276:23109-14.
Epstein,A.C., J.M.Gleadle, L.A.McNeill, K.S.Hewitson, J.O’Rourke, D.R.Mole, M.Mukherji, E.Metzen, M.I.Wilson, A.Dhanda, Y.M.Tian, N.Masson, D.L.Hamilton, P.Jaakkola, R.Barstead, J.Hodgkin, P.H.Maxwell, C.W.Pugh, C.J.Schofield, and P.J.Ratcliffe. 2001. C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell 107:43-54.
Hao,J.C., T.W.Yu, K.Fujisawa, J.G.Culotti, K.Gengyo-Ando, S.Mitani, G.Moulder, R.Barstead, M.Tessier-Lavigne, and C.I.Bargmann. 2001. C. elegans slit acts in midline, dorsal-ventral, and anterior-posterior guidance via the SAX-3/Robo Receptor. Neuron 32:25-38.
Harris,R.L., V.Hombs, and P.M.Silverman. 2001. Evidence that F-plasmid proteins TraV, TraK and TraB assemble into an envelope-spanning structure in Escherichia coli. Mol.Microbiol. 42:757-766.
Kamura,T., D.Burian, H.Khalili, S.L.Schmidt, S.Sato, W.J.Liu, M.N.Conrad, R.C.Conaway, J.W.Conaway, and A.Shilatifard. 2001. Cloning and characterization of ELL-associated proteins EAP45 and EAP20. a role for yeast EAP-like proteins in regulation of gene expression by glucose. J.Biol.Chem. 276:16528-16533.
Kamura,T., D.Burian, Q.Yan, S.L.Schmidt, W.S.Lane, E.Querido, P.E.Branton, A.Shilatifard, R.C.Conaway, and J.W.Conaway. 2001. MUF1, a novel Elongin BC-interacting leucine-rich repeat protein that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin ligase. J.Biol.Chem 276: 29748-53.
Lickteig,K.M., J.S.Duerr, D.L.Frisby, D.H.Hall, J.B.Rand, and D.M.Miller, III. 2001. Regulation of neurotransmitter vesicles by the homeodomain protein UNC-4 and its transcriptional corepressor UNC-37/groucho in Caenorhabditis elegans cholinergic motor neurons. J.Neurosci. 21:2001-2014.
Liu,J., S.Akoulitchev, A.Weber, H.Ge, S.Chuikov, D.Libutti, X.W.Wang, J.W.Conaway, C.C.Harris, R.C.Conaway, D.Reinberg, and D.Levens. 2001. Defective interplay of activators and repressors with TFIIH in xeroderma pigmentosum. Cell 104:353-363.
Spangler,L., X.Wang, J.W.Conaway, R.C.Conaway, and A.Dvir. 2001. TFIIH action in transcription initiation and promoter escape requires distinct regions of downstream promoter DNA. Proc.Natl.Acad.Sci.U.S.A 98:5544-5549.
Zhu,H., J.S.Duerr, H.Varoqui, J.R.McManus, J.B.Rand, and J.D.Erickson. 2001. Analysis of point mutants in the Caenorhabditis elegans vesicular acetylcholine transporter reveals domains involved in substrate translocation. J Biol Chem 276(45):41580-7.
Molecular Immunogenetics Research Program
Capra,J.D. 2001. IDeA: a program whose time has come. Science 294:999.
* Phee,H., W.Rodgers, and K.M.Coggeshall. 2001. Visualization of negative signaling in B cells by quantitative confocal microscopy. Mol.Cell Biol 21:8615-8625.
Rodgers,W. and J.Zavzavadjian. 2001. Glycolipid-enriched membrane domains are assembled into membrane patches by associating with the actin cytoskeleton. Exp.Cell Res. 267:173-183.
* Rossi,M.I., K.L.Medina, K.Garrett, G.Kolar, P.C.Comp, L.D.Shultz, J.D.Capra, P.Wilson, A.Schipul, and P.W.Kincade. 2001. Relatively normal human lymphopoiesis but rapid turnover of newly formed B cells in transplanted nonobese diabetic/SCID mice. J Immunol.167:3033-3042.
Protein Studies Research Program
Ghosh,A.K., G.Bilcer, C.Harwood, R.Kawahama, D.Shin, K.A.Hussain, L.Hong, J.A.Loy, C.Nguyen, G.Koelsch, J.Ermolieff, and J.Tang. 2001. Structure-based design: potent inhibitors of human brain memapsin 2 (beta-secretase). J Med Chem.44:2865-2868.
Judd,D.A., J.H.Nettles, N.Nevins, J.P.Snyder, D.C.Liotta, J.Tang, J.Ermolieff, R.F.Schinazi, and C.L.Hill. 2001. Polyoxometalate HIV-1 protease inhibitors. A new mode of protease inhibition. J.Am.Chem.Soc. 123:886-897.
* Loy,J.A., X.Lin, M.Schenone, F.J.Castellino, X.C.Zhang, and J.Tang. 2001. Domain interactions between streptokinase and human plasminogen. Biochemistry 40:14686-14695.
Turner, R.T. III, G.Koelsch, L.Hong, P.Castenheira, A.Ghosh, and J.Tang. 2001. Subsite specificity of memapsin 2 (beta-secretase): implications for inhibitor design. Biochemistry 40:10001-10006.
* indicates a publication with more than one department involved.