Coagulation Biology Laboratory

The Coagulation Biology Laboratory, headed by Charles T. Esmon, Ph.D., investigates the fundamental mechanisms involved in blood coagulation, including complex biological processes such as inflammation, cancer and cardiovascular disease.

A multidisciplinary approach is utilized to address these questions at a molecular level. These approaches encompass all aspects of modern vascular biology including structural biology, structure-function analysis of enzymes and receptors, regulation of the relevant genes, in vivo studies using transgenic and gene deletion approaches, cell biology, protein chemistry, physiological studies, spectral and other biophysical methods for analyzing protein-protein, membrane-protein and cell-cell interactions. This multidisciplinary approach is designed to allow identification of new factors and the mechanisms which regulate the complex processes of coagulation and inflammation and then to be able to translate these findings into an appreciation of their physiological role and their clinical relevance. In addition to their contributions to a fundamental understanding of these systems, the studies have clinical relevance to heart attack, trauma, cancer, stroke, septic shock, hemophilia, organ rejection in transplantation and miscarriages associated with SLE. Several findings made by members of the laboratory have generated patents and licenses leading to development and application of new diagnostics and therapeutics.

Coagulation Biology Laboratory, MS 51
Oklahoma Medical Research Foundation
825 N.E. 13th Street
Oklahoma City, OK 73104

Phone: (405) 271-6474
Fax: (405) 271-2870
E-mail: Charles-Esmon@omrf.org