What We Do
The Coagulation Biology Laboratory, headed by Charles T. Esmon, Ph.D., investigates the fundamental mechanisms involved in blood coagulation, including complex biological processes such as inflammation, cancer and cardiovascular disease.
A multidisciplinary approach is utilized to address these questions at a molecular level. These approaches encompass all aspects of modern vascular biology including structural biology, structure-function analysis of enzymes and receptors, regulation of the relevant genes, in vivo studies using transgenic and gene deletion approaches, cell biology, protein chemistry, physiological studies, spectral and other biophysical methods for analyzing protein-protein, membrane-protein and cell-cell interactions. This multidisciplinary approach is designed to allow identification of new factors and the mechanisms which regulate the complex processes of coagulation and inflammation and then to be able to translate these findings into an appreciation of their physiological role and their clinical relevance. In addition to their contributions to a fundamental understanding of these systems, the studies have clinical relevance to heart attack, trauma, cancer, stroke, septic shock, hemophilia, organ rejection in transplantation and miscarriages associated with SLE. Several findings made by members of the laboratory have generated patents and licenses leading to development and application of new diagnostics and therapeutics.
Madhusudhan T, Wang H, Ghosh S, Dong W, Kumar V, Al-Dabet MM, Manoharan J, Nazir S, Elwakiel A, Bock F, Kohli S, Marquardt A, Sögüt I, Shahzad K, Müller AJ, Esmon CT, Nawroth PP, Reiser J, Chavakis T, Ruf W, Isermann B. Signal integration at the PI3K-p85-XBP1 hub endows coagulation protease activated protein C with
insulin like function. Blood. 2017 Jul 7. pii: blood-2017-02-767921. PMID: 28687614
McDonald B, Davis RP, Kim SJ, Tse M, Esmon CT, Kolaczkowska E, Jenne CN. Platelets and neutrophil extracellular traps collaborate to promote intravascular coagulation during sepsis in mice. Blood. 2017 Mar 9;129(10):1357-67. PMCID: PMC5345735
Shaw MA, Kombrinck KW, McElhinney KE, Sweet DR, Flick MJ, Palumbo JS, Cheng M, Esmon NL, Esmon CT, Brill A, Wagner DD, Degen JL, Mullins ES. Limiting prothrombin activation to meizothrombin is compatible with survival but significantly alters hemostasis in mice. Blood. 2016 Aug 4;128(5):721-31. PMCID:PMC4974202
Coagulation Biology Laboratory, MS 51
Oklahoma Medical Research Foundation
825 N.E. 13th Street
Oklahoma City, OK 73104
Phone: (405) 271-6474
Fax: (405) 271-2870