What We Do
The Coagulation Biology Laboratory, headed by Charles T. Esmon, Ph.D., investigates the fundamental mechanisms involved in blood coagulation, including complex biological processes such as inflammation, cancer and cardiovascular disease.
A multidisciplinary approach is utilized to address these questions at a molecular level. These approaches encompass all aspects of modern vascular biology including structural biology, structure-function analysis of enzymes and receptors, regulation of the relevant genes, in vivo studies using transgenic and gene deletion approaches, cell biology, protein chemistry, physiological studies, spectral and other biophysical methods for analyzing protein-protein, membrane-protein and cell-cell interactions. This multidisciplinary approach is designed to allow identification of new factors and the mechanisms which regulate the complex processes of coagulation and inflammation and then to be able to translate these findings into an appreciation of their physiological role and their clinical relevance. In addition to their contributions to a fundamental understanding of these systems, the studies have clinical relevance to heart attack, trauma, cancer, stroke, septic shock, hemophilia, organ rejection in transplantation and miscarriages associated with SLE. Several findings made by members of the laboratory have generated patents and licenses leading to development and application of new diagnostics and therapeutics.
Lopez-Ramirez MA, Pham A, Girard R, Wyseure T, Hale P, Yamashita A, Koskimäki J, Polster S, Saadat L, Romero IA, Esmon CT, Lagarrigue F, Awad IA, Mosnier LO, Ginsberg MH. Cerebral cavernous malformations form an anticoagulant vascular domain in humans and mice. Blood 133:193-204, 2019 January, PMID: 30442679, PMCID: PMC6337879
Vincent JL, Francois B, Zabolotskikh I, Daga MK, Lascarrou JB, Kirov MY, Pettilä V, Wittebole X, Meziani F, Mercier E, Lobo SM, Barie PS, Crowther M, Esmon CT, Fareed J, Gando S, Gorelick KJ, Levi M, Mira JP, Opal SM, Parrillo J, Russell JA, Saito H, Tsuruta K, Sakai T, Fineberg D, SCARLET Trial Group.. Effect of a Recombinant Human Soluble Thrombomodulin on Mortality in Patients With Sepsis-Associated Coagulopathy: The SCARLET Randomized Clinical Trial. JAMA, 2019 May, PMID: 31104069
Ashar HK, Mueller NC, Rudd JM, Snider TA, Achanta M, Prasanthi M, Pulavendran S, Thomas PG, Ramachandran A, Malayer JR, Ritchey JW, Rajasekhar R, Chow VTK, Esmon CT, Teluguakula N. The Role of Extracellular Histones in Influenza Virus Pathogenesis. Am J Pathol 188:135-148, 2018 January, PMID: 29107075, PMCID: PMC5745522
Shahzad K, Gadi I, Nazir S, Al-Dabet MM, Kohli S, Bock F, Breitenstein L, Ranjan S, Fuchs T, Halloul Z, Nawroth PP, Pelicci PG, Braun-Dullaeus RC, Camerer E, Esmon CT, Isermann B. Activated protein C reverses epigenetically sustained p66Shc expression in plaque-associated macrophages in diabetes. Commun Biol 1:104, 2018 August, PMID: 30271984, PMCID: PMC6123684
Coagulation Biology Laboratory, MS 51
Oklahoma Medical Research Foundation
825 N.E. 13th Street
Oklahoma City, OK 73104
Phone: (405) 271-6474
Fax: (405) 271-2870