Coagulation Biology Laboratory

The Coagulation Biology Laboratory, headed by Charles T. Esmon, Ph.D., investigates the fundamental mechanisms involved in blood coagulation, including complex biological processes such as inflammation, cancer and cardiovascular disease.

A multidisciplinary approach is utilized to address these questions at a molecular level. These approaches encompass all aspects of modern vascular biology including structural biology, structure-function analysis of enzymes and receptors, regulation of the relevant genes, in vivo studies using transgenic and gene deletion approaches, cell biology, protein chemistry, physiological studies, spectral and other biophysical methods for analyzing protein-protein, membrane-protein and cell-cell interactions. This multidisciplinary approach is designed to allow identification of new factors and the mechanisms which regulate the complex processes of coagulation and inflammation and then to be able to translate these findings into an appreciation of their physiological role and their clinical relevance. In addition to their contributions to a fundamental understanding of these systems, the studies have clinical relevance to heart attack, trauma, cancer, stroke, septic shock, hemophilia, organ rejection in transplantation and miscarriages associated with SLE. Several findings made by members of the laboratory have generated patents and licenses leading to development and application of new diagnostics and therapeutics.

2018

Lopez-Ramirez MA, Pham A, Girard R, Wyseure T, Hale P, Yamashita A, Koskimäki J, Polster S, Saadat L, Romero IA, Esmon CT, Lagarrigue F, Awad IA, Mosnier LO, Ginsberg MH.  Cerebral cavernous malformations form an anticoagulant vascular domain.  Blood. 2018 Nov 15. pii: blood-2018-06-856062.  PMID:30442679

Shahzad K, Gadi I, Nazir S, Al-Dabet MM, Kohli S, Bock F, Breitenstein L, Ranjan S, Fuchs T, Halloul Z, Nawroth PP, Pelicci PG, Braun-Dullaeus RC, Camerer E, Esmon CT, Isermann B.  Activated protein C reverses epigenetically sustained p66^Shc expression in plaque-associated macrophages in diabetes.  Commun Biol. 2018 Aug 6;1:104.  PMID:30271984

2017

Ashar HK, Mueller NC, Rudd JM, Snider TA, Achanta M, Prasanthi M, Pulavendran S, Thomas PG, Akhilesh R, Malayer JR, Ritchey JW, Rajasekhar R, Chow VT, Esmon CT, Teluguakula. The role of extracellular histones in influenza virus pathogenesis.  N. Am J Pathol. 2017 Oct 26. pii: S0002-9440(17). PMID:29107075

Li T, Lee W, Hara H, Long C, Ezzelarab M, Ayares D, Huang H, Wang Y, Esmon CT, Cooper DKC, Iwase H.   An Investigation of Extracellular Histones in Pig-To-Baboon Organ Xenotransplantation. Transplantation. 2017 Oct;101(10):2330-9. PMID:28157735 

Madhusudhan T, Wang H, Ghosh S, Dong W, Kumar V, Al-Dabet MM, Manoharan J, Nazir S, Elwakiel A, Bock F, Kohli S, Marquardt A, Sögüt I, Shahzad K, Müller AJ, Esmon CT, Nawroth PP, Reiser J, Chavakis T, Ruf W, Isermann B. Signal integration at the PI3K-p85-XBP1 hub endows coagulation protease activated protein C with
insulin like function. Blood. 2017 Jul 7. pii: blood-2017-02-767921. PMID: 28687614

McDonald B, Davis RP, Kim SJ, Tse M, Esmon CT, Kolaczkowska E, Jenne CN. Platelets and neutrophil extracellular traps collaborate to promote intravascular coagulation during sepsis in mice. Blood. 2017 Mar 9;129(10):1357-67. PMCID: PMC5345735

* publications by more than one department or program

Coagulation Biology Laboratory, MS 51
Oklahoma Medical Research Foundation
825 N.E. 13th Street
Oklahoma City, OK 73104

Phone: (405) 271-6474
Fax: (405) 271-2870
E-mail: Charles-Esmon@omrf.org