Although my general interest is the biochemistry of naturally occurring conjugated proteins, most of my research activities have been centered around chemical, metabolic and pathophysiologic properties of human plasma lipoproteins. During recent years, these studies have been mainly concerned with the atherogenic potentials of triglyceride-rich and cholesterol-rich apoB-containing lipoproteins, their concentrations in primary and secondary hyperlipoproteinemias and their specific response to various therapeutic interventions. All these studies are based on the concept that apolipoprotein-defined lipoprotein subclasses are the fundamental chemical and metabolic entities of the lipid transport system.
Education
Diploma in Chemical Engineering, University of Zagreb, Yugoslavia, 1948
Ph.D., University of Zagreb, Yugoslavia, 1956 in Organic Chemistry
Honors and Awards
1988 Honorary Doctorate Degree, University of Lille, France
1988 “Albert Calmette” Medal for Scientific Achievements
1988 Medal of the City of Lille, France
1990 Distinguished Career Scientist, OMRF
1993 Honorary Diploma, National University of La Plata, Argentina
1994 Honorary Doctorate Degree, University of Buenos Aires, Argentina
1994 Special Recognition Award, Council on Arteriosclerosis, American Heart Association
1994 Member, Argentinean National Academy of Exact, Physical and Natural Sciences
1995 Honorary Consultant, Ministry of Health, Province of Buenos Aires
1999 Honorary Doctorate Degree, University of Goteborg, Goteborg Sweden
Teaching Activities
Sponsor and Supervisor of 2 M.S. Degree candidates and 20 Ph.D. candidates.
Sponsor of 72 postdoctoral fellows.
Memberships
American Chemical Society
American Heart Association, Council on Arteriosclerosis
Sigma Xi
American Association for the Advancement of Science
American Oil Chemists’ Society
American Society for Biochemistry and Molecular Biology
Editorial Activities
Technical Editor, Croatica Chemica Acta (1954-1957)
Associate Editor, Lipids (1973-1976)
Membership on Regional and National Research Committees
1966-1969 Research Committee, Oklahoma Heart Association
1974-1978 Southwestern Regional Research and Advisory Committee, American Heart Association
1967-1970 Biochemistry Study Section, American Heart Association
1971 Metabolism Study Section, National Heart, Lung and Blood Institute, NIH
1974-1977 SCOR Program, National Heart, Lung and Blood Institute
1983-1985 Merit Review Board for Basic Sciences, Veterans Administration Hospital
1985-1988 Committee on the Standardization of Apolipoproteins, National Heart, Lung and Blood Institute, NIH
1984-1995 Collaborative Clinical Nutrition Unit Review Committee, National Institute for Diabetes, Digestive and Kidney Disease, NIH
Board Memberships
Chairman, Annual Research Council, Oklahoma Zoological Garden (1972-1974)
Trustee, Oklahoma Zoological Society (1972-present)
Honorary Life Director, Oklahoma Zoological Garden (1991-present)
Member, Scientific Advisory Board, Lipid Sciences, Inc. (1999-present)
Member, Rosuvastatin Advisory Board, AstraZeneca (2001-present)
Member, Executive Committee, Oklahoma Zoological Garden (2004-2005)
Joined OMRF Scientific Staff in 1960.
Although my general interest is the biochemistry of naturally occurring conjugated proteins, most of my research activities have been centered around chemical, metabolic and pathophysiologic properties of human plasma lipoproteins. During recent years, these studies have been mainly concerned with the atherogenic potentials of triglyceride-rich and cholesterol-rich apoB-containing lipoproteins, their concentrations in primary and secondary hyperlipoproteinemias and their specific response to various therapeutic interventions. All these studies are based on the concept that apolipoprotein-defined lipoprotein subclasses are the fundamental chemical and metabolic entities of the lipid transport system.
Recent Publications
Samuelsson O, Attman PO, Gause-Nilsson I, Svensson MK, Alaupovic P. Dual PPAR alpha / gamma Agonism Normalizes Lipoprotein Profile of Renal Dyslipidemia. PPAR Res 2013:391628, 2013. [Abstract]
Blackett P, Tryggestad J, Krishnan S, Li S, Xu W, Alaupovic P, Quiroga C, Copeland K. Lipoprotein abnormalities in compound heterozygous lipoprotein lipase deficiency after treatment with a low-fat diet and Orlistat. J Clin Lipidol 7:132-139, 2013. [Abstract]
McNeal CJ, Chatterjee S, Hou J, Worthy L, Larner C, Macfarlane RD, Alaupovic P, Brocia R. Human HDL Containing a Novel ApoC-I Isoform Induces Smooth Muscle Cell Apoptosis. Cardiovasc Res 98:83-93, 2013. [Abstract]
Selected Publications
Roussell MA, Hill AM, Gaugler TL, West SG, Vanden Heuvel JP, Alaupovic P, Gillies PJ, Kris-Etherton PM. Beef in an Optimal Lean Diet study: effects on lipids, lipoproteins, and apolipoproteins. Am J Clin Nutr 95:9-16, 2012. [Abstract]
Attman PO, Samuelsson O, Alaupovic P. The effect of decreasing renal function on lipoprotein profiles. Nephrol Dial Transplant 26:2572-2575, 2011. [Abstract]
Bagdade J, Pedersen BK, Schwenke D, Saremi A, Alaupovic P. Acute effects of interleukin-6 infusion on apo-B-containing lipoprotein subclasses in humans. Scand J Clin Lab Invest 71:449-455, 2011. [Abstract]
Lee DM, Jackson KW, Knowlton N, Wages J, Alaupovic P, Samuelsson O, Saeed A, Centola M, Attman PO. Oxidative stress and inflammation in renal patients and healthy subjects. PLoS One 6:e22360, 2011. [Abstract]
Nowakowska FE, Herlitz H, Saeed A, Attman PO, Jensen G, Alaupovic P, Guron G. Lipoprotein abnormalities in patients with atherosclerotic renovascular disease. Kidney Blood Press Res 34:311-319, 2011. [Abstract]
Alaupovic P. Apolipoprotein composition as the basis for classifying plasma lipoproteins. Characterization of ApoA- and ApoB-containing lipoprotein families. Prog Lipid Res 30:105-138, 1991. [Abstract]
Lipid and Lipoprotein Laboratory, MS 42
Oklahoma Medical Research Foundation
825 N.E. 13th Street
Oklahoma City, OK 73104
Phone: (405) 271-7703
Fax: (405) 271-8575
E-mail: Petar-Alaupovic@omrf.org
