2009 Scientific Publications

Advanced Magnetic Resonance Center

Condac E, Dale GL, Bender-Neal D, Ferencz B, Towner R, Hinsdale ME. Xylosyltransferase II is a significant contributor of circulating xylosyltransferase levels and platelets constitute an important source of xylosyltransferase in serum. Glycobiology 19:829-833, 2009. [Abstract]

* Gomez-Mejiba SE, Zhai Z, Akram H, Deterding LJ, Hensley K, Smith N, Towner RA, Tomer KB, Mason RP, Ramirez DC. Immuno-spin trapping of protein and DNA radicals: “tagging” free radicals to locate and understand the redox process. Free Radic Biol Med 46:853-65, 2009. [Abstract]

* Griffitts J, Tesiram YA, Reid GE, Saunders D, Floyd RA, Towner RA. In vivo magnetic resonance spectroscopy (MRS) assessment of altered fatty acyl unsaturation in liver tumor formation of a TGFalpha /c-myc transgenic mouse model. J Lipid Res  50:611-622, 2009. [Abstract]

Mitschelen M, Garteiser P, Carnes BA, Farley JA, Doblas S, Demoe JH, Warrington JP, Yan H, Nicolle MM, Towner R, Sonntag WE.  Basal and hypercapnia-altered cerebrovascular perfusion predict mild cognitive impairment in aging rodents. Neuroscience 164:918-928, 2009. [Abstract]

Arthritis and Immunology Research Program

Abelson AK, Delgado-Vega AM, Kozyrev SV, Sanchez E, Velazquez-Cruz R, Eriksson N, Wojcik J, Linga Reddy MV, Lima G, D’Alfonso S, Migliaresi S, Baca V, Orozco L, Witte T, Ortego-Centeno N, AADEA group, Abderrahim H, Pons-Estel BA, Gutierrez C, Suarez A, Gonzalez-Escribano MF, Martin J, Alarcón-Riquelme ME.  STAT4 associates with systemic lupus erythematosus through two independent effects that correlate with gene expression and act additively with IRF5 to increase risk. Ann Rheum Dis 68:1746-1753, 2009. [Abstract]

Agrawal H, Jacob N, Carreras E, Bajana S, Putterman C, Turner S, Neas B, Mathian A, Koss MN, Stohl W, Kovats S, Jacob CO.  Deficiency of Type I IFN Receptor in Lupus-prone New Zealand Mixed 2328 Mice decreases dendritic cell numbers and activation and protects from disease. J Immunol 183:6021-6029, 2009. [Abstract]

Alex P, Zachos NC, Nguyen T, Gonzales L, Chen TE, Conklin LS, Centola M, Li X. Distinct cytokine patterns identified from multiplex profiles of murine DSS and TNBS-induced colitis. Inflamm Bowel Dis 15:341-352, 2009. [Abstract]

* Armstrong DL, Reiff A, Myones BL, Quismorio FP, Jr., Klein-Gitelman M, McCurdy D, Wagner-Weiner L, Silverman E, Ojwang JO, Kaufman KM, Kelly JA, Merrill JT, Harley JB, Bae SC, Vyse TJ, Gilkeson GS, Gaffney PM, Moser KL, Putterman C, Edberg JC, Brown EE, Ziegler J, Langefeld CD, Zidovetzki R, Jacob CO.   Identification of new SLE-associated genes with a two-step Bayesian study design. Genes Immun 10:446-456, 2009. [Abstract]

Baker AR, Goodloe RJ, Larkin EK, Baechle DJ, Song YE, Phillips LS, Gray-McGuire CL.  Multivariate association analysis of the components of metabolic syndrome from the Framingham Heart Study. BMC Proc 3 Suppl 7:S42, 2009. [Abstract]

Barcellos LF, May SL, Ramsay PP, Quach HL, Lane JA, Nititham J, Noble JA, Taylor KE, Quach DL, Chung SA, Kelly JA, Moser KL, Behrens TW, Seldin MF, Thomson G, Harley JB, Gaffney PM, Criswell LA. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. PLoS Genet 5:e1000696, 2009. [Abstract]

* Bates JS, Lessard CJ, Leon JM, Nguyen T, Battiest LJ, Rodgers J, Kaufman KM, James JA, Gilkeson GS, Kelly JA, Humphrey MB, Harley JB, Gray-McGuire C, Moser KL, Gaffney PM. Meta-analysis and imputation identifies a 109 kb risk haplotype spanning TNFAIP3 associated with lupus nephritis and hematologic manifestations. Genes Immun 10:470-477, 2009. [Abstract]

Bockus LB, Scofield RH. Phosphoprotein detection on protein electroblot using a phosphate-specific fluorophore. Methods Mol Biol 536:385-393, 2009. [Abstract]

Canzler U, Bartsch H, Grossmann K, Lehmann W, Conrad K, Kurien BT, Dorri Y, Scofield RH, Bachmann M. A miniaturized blotting system for simultaneous detecting of different autoantibodies. Methods Mol Biol 536:129-137, 2009.[Abstract]

Canzler U, Bartsch H, Ulitzsch S, Kurien BT, Dorri Y, Scofield RH, Grossmann K, Lehmann W, Pilarsky C, Denz A, Grutzmann R, Conrad K, Schmitz M, Rieber EP, Distler W, Bachmann MP.   Detection of autoantibodies to tumour-associated antigens in sera of patients with systemic autoimmunity using a novel protein microblot array. Scand J Immunol 69:563-569, 2009. [Abstract]

Chung SA, Tian C, Taylor KE, Lee AT, Ortmann WA, Hom G, Graham RR, Nititham J, Kelly JA, Morrisey J, Wu H, Yin H, Alarcón-Riquelme ME, Tsao BP, Harley JB, Gaffney PM, Moser KL, Manzi S, Petri M, Gregersen PK, Langefeld CD, Behrens TW, Seldin MF, Criswell LA. European population substructure is associated with mucocutaneous manifestations and autoantibody production in systemic lupus erythematosus. Arthritis Rheum 60:2448-2456,
2009. [Abstract]

Cooney CM, Bruner GR, Aberle T, Namjou-Khales B, Myers LK, Feo L, Li S, D’Souza A, Ramirez A, Harley JB, Scofield RH. 46,X,del(X)(q13) Turner’s syndrome women with systemic lupus erythematosus in a pedigree multiplex for SLE. Genes Immun 10:478-481, 2009. [Abstract]

D’Souza A, Scofield RH. Protein stains to detect antigen on membranes. Methods Mol Biol 536:433-440, 2009. [Abstract]

* Daum JR, Wren JD, Daniel JJ, Sivakumar S, McAvoy JN, Potapova TA, Gorbsky GJ. Ska3 is
required for spindle checkpoint silencing and the maintenance of chromosome cohesion
in mitosis. Curr Biol 19:1467-1472, 2009.[Abstract]

Delgado-Vega AM, Abelson AK, Sanchez E, Witte T, D’Alfonso S, Galeazzi M, Jimenez-Alonso J, Pons-Estel BA, Martin J, Alarcón-Riquelme ME.  Replication of the TNFSF4 (OX40L) promoter region association with systemic lupus erythematosus. Genes Immun 10:248-253, 2009. [Abstract]

Deshmukh H, Kim-Howard X, Nath SK.  Replication of recently identified associated single-nucleotide polymorphisms from six autoimmune diseases in Genetic Analysis Workshop 16 rheumatoid arthritis data. BMC Proc 3 Suppl 7:S31, 2009. [Abstract]

Dillon SP, D’Souza A, Kurien BT, Scofield RH.  Systemic lupus erythematosus and C1q: a quantitative ELISA for determining C1q levels in serum. Biotechnol J 4:1210-1214, 2009. [Abstract]

Dorri Y, Khalili AW, Scofield RH. Whole and strip nitrocellulose membrane as well as a new-line-immunoblotting of antigen using the chemiluminescence technique. Methods Mol Biol 536:417-432, 2009. [Abstract]

Dorri Y, Kurien BT, Scofield RH.  A Simpler and faster version of two-dimensional gel electrophoresis using vertical, mini SDS-PAGE apparatus. Iran J Chem Chem Eng 28:51-56, 2009.

* Douglas KB, Windels DC, Zhao J, Gadeliya AV, Wu H, Kaufman KM, Harley JB, Merrill J, Kimberly RP, Alarcon GS, Brown EE, Edberg JC, Ramsey-Goldman R, Petri M, Reveille JD, Vila LM, Gaffney PM, James JA, Moser KL, Alarcón-Riquelme ME, Vyse TJ, Gilkeson GS, Jacob CO, Ziegler JT, Langefeld CD, Ulgiati D, Tsao BP, Boackle SA. Complement receptor 2 polymorphisms associated with systemic lupus erythematosus modulate alternative splicing. Genes Immun 10:457-469, 2009. [Abstract]

Dozmorov I, Lefkovits I.  Internal standard-based analysis of microarray data. Part 1: analysis of differential gene expressions. Nucleic Acids Res 37:6323-6339, 2009. [Abstract]

Dozmorov MG, Hurst RE, Culkin DJ, Kropp BP, Frank MB, Osban J, Penning TM, Lin HK.  Unique patterns of molecular profiling between human prostate cancer LNCaP and PC-3 cells. Prostate 69:1077-1090, 2009. [Abstract]

Duarte-Rey C, Pardo AL, Rodriguez-Velosa Y, Mantilla RD, Anaya JM, Rojas-Villarraga A.  HLA class II association with autoimmune hepatitis in Latin America: a meta-analysis. Autoimmun Rev 8:325-331, 2009. [Abstract]

Duty JA, Szodoray P, Zheng NY, Koelsch KA, Zhang Q, Swiatkowski M, Mathias M, Garman L, Helms C, Nakken B, Smith K, Farris AD, Wilson PC.  Functional anergy in a subpopulation of naive B cells from healthy humans that express autoreactive immunoglobulin receptors. J Exp Med 206:3096-3105, 2009. [Abstract]

Emamian ES, Leon JM, Lessard CJ, Grandits M, Baechler EC, Gaffney PM, Segal B, Rhodus NL, Moser KL. Peripheral blood gene expression profiling in Sjögren’s syndrome. Genes Immun 10:285-296, 2009. [Abstract]

Fei Y, Webb R, Cobb BL, Direskeneli H, Saruhan-Direskeneli G, Sawalha AH. Identification of novel genetic susceptibility loci for Behcet’s disease using a genome-wide association study. Arthritis Res Ther 11:R66, 2009. [Abstract]

Frank MB, Wang S, Aggarwal A, Knowlton N, Jiang K, Chen Y, McKee R, Chaser B, McGhee T, Osban J, Jarvis JN. Disease-associated pathophysiologic structures in pediatric rheumatic diseases show characteristics of scale-free networks seen in physiologic systems: implications for pathogenesis and treatment. BMC Med Genomics 2:9, 2009. [Abstract]

Frank MB, Yang Q, Osban J, Azzarello JT, Saban MR, Saban R, Ashley RA, Welter JC, Fung KM, Lin HK. Frankincense oil derived from Boswellia carteri induces tumor cell specific cytotoxicity. BMC Complement Altern Med 9:6, 2009. [Abstract]

Gajecka M, Radhakrishna U, Winters D, Nath SK, Rydzanicz M, Ratnamala U, Ewing K, Molinari A, Pitarque JA, Lee K, Leal SM, Bejjani BA. Localization of a gene for keratoconus to a 5.6-Mb interval on 13q32. Invest Ophthalmol Vis Sci 50:1531-1539, 2009. [Abstract]

* Gomez-Mejiba SE, Zhai Z, Akram H, Pye QN, Hensley K, Kurien BT, Scofield RH, Ramirez DC. Inhalation of environmental stressors and chronic inflammation: autoimmunity and neurodegeneration. Mutat Res 674:62-72, 2009. [Abstract]

Gray-McGuire C, Bochud M, Goodloe R, Elston RC.  Genetic association tests: a method for the joint analysis of family and case-control data. Hum Genomics 4:2-20, 2009. [Abstract]

Gray-McGuire C, Song Y, Morris NJ, Stein CM.  Comparison of univariate and multivariate linkage analysis of traits related to hypertension. BMC Proc 3 Suppl 7:S99, 2009. [Abstract]

Gu J, Wei YL, Wei JC, Huang F, Jan MS, Centola M, Frank MB, Yu D.  Identification of RGS1 as a candidate biomarker for undifferentiated spondylarthritis by genome-wide expression profiling and real-time polymerase chain reaction. Arthritis Rheum 60:3269-3279, 2009. [Abstract]

Gu Y, Harley IT, Henderson LB, Aronow BJ, Vietor I, Huber LA, Harley JB, Kilpatrick JR, Langefeld CD, Williams AH, Jegga AG, Chen J, Wills-Karp M, Arshad SH, Ewart SL, Thio CL, Flick LM, Filippi MD, Grimes HL, Drumm ML, Cutting GR, Knowles MR, Karp CL. Identification of IFRD1 as a modifier gene for cystic fibrosis lung disease. Nature 458:1039-1042, 2009. [Abstract]

* Guo L, Deshmukh H, Lu R, Vidal GS, Kelly JA, Kaufman KM, Dominguez N, Klein W, Kim-Howard X, Bruner GR, Scofield RH, Moser KL, Gaffney PM, Dozmorov IM, Gilkeson GS, Wakeland EK, Li QZ, Langefeld CD, Marion MC, Williams AH, Divers J, Alarcon GS, Brown EE, Kimberly RP, Edberg JC, Ramsey-Goldman R, Reveille JD, McGwin G, Jr., Vila LM, Petri MA, Vyse TJ, Merrill JT, James JA, Nath SK, Harley JB, Guthridge JM. Replication of the BANK1 genetic association with systemic lupus erythematosus in a European-derived population. Genes Immun 10:531-538, 2009. [Abstract]

* Han S, Kim-Howard X, Deshmukh H, Kamatani Y, Viswanathan P, Guthridge JM, Thomas K, Kaufman KM, Ojwang J, Rojas-Villarraga A, Baca V, Orozco L, Rhodes B, Choi CB, Gregersen PK, Merrill JT, James JA, Gaffney PM, Moser KL, Jacob CO, Kimberly RP, Harley JB, Bae SC, Anaya JM, Alarcón-Riquelme ME, Matsuda K, Vyse TJ, Nath SK. Evaluation of imputation-based association in and around the integrin-{alpha}-M (ITGAM) gene replication of robust association between a non-synonymous functional variant within ITGAM and systemic lupus erythematosus (SLE). Hum Mol Genet 18:1171-1180, 2009. [Abstract]

Harley IT, Kaufman KM, Langefeld CD, Harley JB, Kelly JA. Genetic susceptibility to SLE: new insights from fine mapping and genome-wide association studies.  Nat Rev Genet 10:285-290,  2009. [Abstract]

* Jacob CO, Zhu J, Armstrong DL, Yan M, Han J, Zhou XJ, Thomas JA, Reiff A, Myones BL, Ojwang JO, Kaufman KM, Klein-Gitelman M, McCurdy D, Wagner-Weiner L, Silverman E, Ziegler J, Kelly JA, Merrill JT, Harley JB, Ramsey-Goldman R, Vila LM, Bae SC, Vyse TJ, Gilkeson GS, Gaffney PM, Moser KL, Langefeld CD, Zidovetzki R, Mohan C. Identification of IRAK1 as a risk gene with critical role in the pathogenesis of systemic lupus erythematosus. Proc Natl Acad Sci U S A 106:6256-6261, 2009. [Abstract]

Jarvis JN, Jiang K, Frank MB, Knowlton N, Aggarwal A, Wallace CA, McKee R, Chaser B, Tung C, Smith LB, McGhee JL, Chen Y, Osban J, O’Neil KM, Centola M. Gene expression profiling in neutrophils from children with polyarticular juvenile idiopathic arthritis. Arthritis Rheum 60:1488-1495, 2009. [Abstract]

Jiang K, Krous LC, Knowlton N, Chen Y, Frank MB, Cadwell C, Centola M, Jarvis JN.  Ablation of Stat3 by siRNA alters gene expression profiles in JEG-3 cells: a systems biology approach. Placenta 30:806-815, 2009. [Abstract]

Knowlton N, Jiang K, Frank MB, Aggarwal A, Wallace C, McKee R, Chaser B, Tung C, Smith L, Chen Y, Osban J, O’neil K, Centola M, McGhee JL, Jarvis JN. The meaning of clinical remission in polyarticular juvenile idiopathic arthritis: gene expression profiling in peripheral blood mononuclear cells identifies distinct disease states. Arthritis Rheum 60:892-900, 2009. [Abstract]

Kurien BT. Affinity purification of autoantibodies from an antigen strip excised from a nitrocellulose protein blot. Methods Mol Biol 536:201-211, 2009. [Abstract]

Kurien BT. Sending secret messages on nitrocellulose membrane and the use of a molecular pen for orientation in ECL membrane assays. Methods Mol Biol 536:573-581, 2009. [Abstract]

Kurien BT. Strip immunoblotting of multiple antigenic peptides to nitrocellulose membrane. Methods Mol Biol 536:191-199, 2009. [Abstract]

Kurien BT, Bachmann M. Detection of calcium binding by Ro 60 multiple antigenic peptides on nitrocellulose membrane using Quin-2-. Methods Mol Biol 536:483-490, 2009. [Abstract]

Kurien BT, Bachmann M. Renaturation of recombinant Ro 60 autoantigen by calcium ions on PVDF membrane. Methods Mol Biol 536:299-306, 2009. [Abstract]

Kurien BT, Scofield RH. A brief review of other notable protein blotting methods. Methods Mol Biol 536:367-384, 2009. [Abstract]

Kurien BT, Scofield RH. A brief review of other notable protein detection methods on blots. Methods Mol Biol 536:557-571, 2009. [Abstract]

Kurien BT, Scofield RH. Affinity immunoblotting for analysis of antibody clonotype distribution in a lupus patient developing anti-ro 60 over time. Methods Mol Biol 536:45-53, 2009. [Abstract]

Kurien BT, Scofield RH. Heat-solubilized curcumin should be considered in clinical trials for increasing bioavailability. Clin Cancer Res 15:747, 2009. [Abstract]

Kurien BT, Scofield RH. Introduction to protein blotting. Methods Mol Biol 536:9-22, 2009. [Abstract]

Kurien BT, Scofield RH. Nonelectrophoretic bidirectional transfer of a single SDS-PAGE gel with multiple antigens to obtain 12 immunoblots. Methods Mol Biol 536:55-65, 2009. [Abstract]

Kurien BT, Scofield RH.  Oral administration of heat-solubilized curcumin for potentially increasing curcumin bioavailability in experimental animals. Int J Cancer 125:1192-1193, 2009. [Abstract]

Kurien BT, Scofield RH. Tryptic peptide purification using polyvinylidene difluoride membrane for matrix-assisted laser desorption ionization time of flight mass spectrometry. Methods Mol Biol 536:39-44, 2009. [Abstract]

Kurien BT, Scofield RH. Ultrarapid electrophoretic transfer of high and low molecular weight proteins using heat. Methods Mol Biol 536:181-190, 2009. [Abstract]

Li Y, Sawalha AH, Lu Q. Aberrant DNA methylation in skin diseases. J Dermatol Sci 54:143-149, 2009. [Abstract]

* Liu K, Li QZ, Delgado-Vega AM, Abelson AK, Sanchez E, Kelly JA, Li L, Liu Y, Zhou J, Yan M, Ye Q, Liu S, Xie C, Zhou XJ, Chung SA, Pons-Estel B, Witte T, de RE, Bae SC, Barizzone N, Sebastiani GD, Merrill JT, Gregersen PK, Gilkeson GG, Kimberly RP, Vyse TJ, Kim I, D’Alfonso S, Martin J, Harley JB, Criswell LA, Wakeland EK, Alarcón-Riquelme ME, Mohan C, Profile Study Group, Italian Collaborative Group, German Collaborative Group, Spanish Collaborative Group, Argentinian Collaborative Group, SLEGEN Consortium. Kallikrein genes are associated with lupus and glomerular basement membrane-specific antibody-induced nephritis in mice and humans. J Clin Invest 119:911-923, 2009. [Abstract]

Love LA, Weinberg CR, McConnaughey DR, Oddis CV, Medsger TA, Jr., Reveille JD, Arnett FC,
Targoff IN, Miller FW. Ultraviolet radiation intensity predicts the relative distribution of
dermatomyositis and anti-Mi-2 autoantibodies in women. Arthritis Rheum 60:2499-2504,
2009. [Abstract]

* Lu R, Vidal GS, Kelly JA, Delgado-Vega AM, Howard XK, Macwana SR, Dominguez N, Klein W, Burrell C, Harley IT, Kaufman KM, Bruner GR, Moser KL, Gaffney PM, Gilkeson GS, Wakeland EK, Li QZ, Langefeld CD, Marion MC, Divers J, Alarcon GS, Brown EE, Kimberly RP, Edberg JC, Ramsey-Goldman R, Reveille JD, McGwin JG, Vila LM, Petri MA, Bae SC, Cho SK, Bang SY, Kim I, Choi CB, Martin J, Vyse TJ, Merrill JT, Harley JB, Alarcón-Riquelme ME, for the BIOLUPUS and GENLES Multicenter Collaborations, Nath SK, James JA, Guthridge JM. Genetic associations of LYN with systemic lupus erythematosus. Genes Immun 10:397-403, 2009. [Abstract]

* Maeda K, Malykhin A, Teague-Weber BN, Sun XH, Farris AD, Coggeshall KM. Interleukin 6 aborts lymphopoiesis and elevates production of myeloid cells in systemic lupus erythematosis-prone B6.Sle1.Yaa animals. Blood 113:4534-4540, 2009. [Abstract]

Maier S, Hubbell S, Scofield RH. Detection of La/SS-B by Western Blot using nanogold-tagged antibodies and silver enhancement. Methods Mol Biol 536:491-497, 2009. [Abstract]

* Malhotra S, Kovats S, Zhang W, Coggeshall KM. B cell antigen receptor endocytosis and antigen presentation to T cells requires Vav and dynamin. J Biol Chem 284:24088-24097, 2009. [Abstract]

* Malhotra S, Kovats S, Zhang W, Coggeshall KM.  Vav and Rac activation in B cell antigen receptor endocytosis involves Vav recruitment to the adapter protein LAB. J Biol Chem 284:36202-36212, 2009. [Abstract]

Meroni P, Tincani A, Alarcón-Riquelme M, Shoenfeld Y, Borghi M.  European Forum on Antiphospholipid Antibodies: research in progress. Lupus 18:924-929, 2009. [Abstract]

Molineros JE, Kim-Howard X, Deshmukh H, Jacob CO, Harley JB, Nath SK. Admixture in Hispanic Americans: its impact on ITGAM association and implications for admixture mapping in SLE. Genes Immun 10:539-545, 2009. [Abstract]

Morris DL, Graham RR, Erwig LP, Gaffney PM, Moser KL, Behrens TW, Vyse TJ, Graham DS. Variation in the upstream region of P-Selectin (SELP) is a risk factor for SLE. Genes Immun 10:404-413, 2009. [Abstract]

Morris NJ, Gray-McGuire C, Stein CM.  Mendelian randomization in family data. BMC Proc 3 Suppl 7:S45, 2009. [Abstract]

Moser KL, Kelly JA, Lessard CJ, Harley JB.   Recent insights into the genetic basis of systemic lupus erythematosus. Genes Immun 10:373-379, 2009. [Abstract]

* Namjou B, Gray-McGuire C, Sestak AL, Gilkeson GS, Jacob CO, Merrill JT, James JA, Wakeland EK, Li QZ, Langefeld CD, Divers J, Ziegler J, Moser KL, Kelly JA, Kaufman KM, Harley JB.   Evaluation of C1q genomic region in minority racial groups of lupus. Genes Immun 10:517-524, 2009. [Abstract]

Namjou B, Scofield R, Kelly J, Goodmon E, Aberle T, Bruner G, Harley JB. The effects of previous hysterectomy on lupus. Lupus 18:1000-1005, 2009. [Abstract]

* Namjou B, Sestak AL, Armstrong DL, Zidovetzki R, Kelly JA, Jacob N, Ciobanu V, Kaufman KM, Ojwang JO, Ziegler J, Quismorio FP, Jr., Reiff A, Myones BL, Guthridge JM, Nath SK, Bruner GR, Mehrian-Shai R, Silverman E, Klein-Gitelman M, McCurdy D, Wagner-Weiner L, Nocton JJ, Putterman C, Bae SC, Kim YJ, Petri M, Reveille JD, Vyse TJ, Gilkeson GS, Kamen DL, Alarcón-Riquelme ME, Gaffney PM, Moser KL, Merrill JT, Scofield RH, James JA, Langefeld CD, Harley JB, Jacob CO. High-density genotyping of STAT4 reveals multiple haplotypic associations with systemic lupus erythematosus in different racial groups. Arthritis Rheum 60:1085-1095, 2009. [Abstract]

Nassir R, Kosoy R, Tian C, White PA, Butler LM, Silva G, Kittles R, Alarcón-Riquelme ME, Gregersen PK, Belmont JW, De La Vega FM, Seldin MF. An ancestry informative marker set for determining continental origin: validation and extension using human genome diversity panels. BMC Genet 10:39, 2009. [Abstract]

* Nguyen ML, Crowe SR, Kurella S, Teryzan S, Cao B, Ballard JD, James JA, Farris AD. Sequential B-cell epitopes of Bacillus anthracis lethal factor bind lethal toxin-neutralizing antibodies. Infect Immun 77:162-169, 2009. [Abstract]

* Nguyen ML, Terzyan S, Ballard JD, James JA, Farris AD.  The Major neutralizing antibody responses to recombinant anthrax lethal factor and edema factors are directed to non-cross-reactive epitopes. Infect Immun 77:4714-4723, 2009. [Abstract]

Nock NL, Wang X, Thompson CL, Song Y, Baechle D, Raska P, Stein CM, Gray-McGuire C.  Defining genetic determinants of the Metabolic Syndrome in the Framingham Heart Study using association and structural equation modeling methods. BMC Proc 3 Suppl 7:S50, 2009. [Abstract]

Orozco G, Abelson AK, Gonzalez-Gay MA, Balsa A, Pascual-Salcedo D, Garcia A, Fernandez-Gutierrez B, Petersson I, Pons-Estel B, Eimon A, Paira S, Scherbarth HR, Alarcón-Riquelme M, Martin J.  Study of functional variants of the BANK1 gene in rheumatoid arthritis. Arthritis Rheum 60:372-379, 2009. [Abstract]

Pan Y, Sawalha AH. Epigenetic regulation and the pathogenesis of systemic lupus erythematosus. Transl Res 153:4-10, 2009. [Abstract]

* Poole BD, Schneider RI, Guthridge JM, Velte CA, Reichlin M, Harley JB, James JA. Early targets of nuclear RNP humoral autoimmunity in human systemic lupus erythematosus. Arthritis Rheum 60:848-859, 2009. [Abstract]

* Poole BD, Templeton AK, Guthridge JM, Brown EJ, Harley JB, James JA. Aberrant Epstein-Barr viral infection in systemic lupus erythematosus. Autoimmun Rev 8:337-342, 2009. [Abstract]

Ramos PS, Langefeld CD, Bera LA, Gaffney PM, Noble JA, Moser KL. Variation in the ATP-binding cassette transporter 2 gene is a separate risk factor for systemic lupus erythematosus within the MHC. Genes Immun 10:350-355, 2009. [Abstract]

Rojas-Villarraga A, Diaz FJ, Calvo-Paramo E, Salazar JC, Iglesias-Gamarra A, Mantilla RD, Anaya JM.  Familial disease, the HLA-DRB1 shared epitope and anti-CCP antibodies influence time at appearance of substantial joint damage in rheumatoid arthritis. J Autoimmun 32:64-69, 2009. [Abstract]

Sammalisto S, Hiekkalinna T, Schwander K, Kardia S, Weder AB, Rodriguez BL, Doria A, Kelly JA, Bruner GR, Harley JB, Redline S, Larkin EK, Patel SR, Ewan AJ, Weber JL, Perola M, Peltonen L. Genome-wide linkage screen for stature and body mass index in 3.032 families: evidence for sex- and population-specific genetic effects. Eur J Hum Genet 17:258-266, 2009. [Abstract]

Sawalha AH, Harley JB, Scofield RH. Autoimmunity and Klinefelter’s syndrome: when men have two X chromosomes. J Autoimmun 33:31-34, 2009. [Abstract]

Scofield RH.  Genetics of systemic lupus erythematosus and Sjögren’s syndrome. Curr Opin Rheumatol 21:448-453, 2009. [Abstract]

Scofield RH, Oates JC.  The Place of William Osler in the description of systemic lupus erythematosus. Am J Med Sci 338:409-412, 2009. [Abstract]

Smith K, Garman L, Wrammert J, Zheng NY, Capra JD, Ahmed R, Wilson PC. Rapid generation of fully human monoclonal antibodies specific to a vaccinating antigen. Nat Protoc 4:372-384, 2009. [Abstract]

Torgerson TR, Genin A, Chen C, Zhang M, Zhou B, Anover-Sombke S, Frank MB, Dozmorov I, Ocheltree E, Kulmala P, Centola M, Ochs HD, Wells AD, Cron RQ.  FOXP3 inhibits activation-induced NFAT2 expression in T cells thereby limiting effector cytokine expression. J Immunol 183:907-915, 2009. [Abstract]

Trieu EP, Gross JK, Targoff IN. Immunoprecipitation-Western blot for proteins of low abundance. Methods Mol Biol 536:259-275, 2009. [Abstract]

Wahlström J, Dengjel J, Winqvist O, Targoff I, Persson B, Duyar H, Rammensee HG, Eklund A, Weissert R, Grunewald J.  Autoimmune T cell responses to antigenic peptides presented by bronchoalveolar lavage cell HLA-DR molecules in sarcoidosis. Clin Immunol 133:353-363, 2009. [Abstract]

Webb R, Jeffries M, Sawalha AH. Uric acid directly promotes human T-cell activation. Am J Med Sci 337:23-27, 2009. [Abstract]

* Webb R, Merrill JT, Kelly JA, Sestak A, Kaufman KM, Langefeld CD, Ziegler J, Kimberly RP, Edberg JC, Ramsey-Goldman R, Petri M, Reveille JD, Alarcon GS, Vila LM, Alarcón-Riquelme ME, James JA, Gilkeson GS, Jacob CO, Moser KL, Gaffney PM, Vyse TJ, Nath SK, Lipsky P, Harley JB, Sawalha AH. A polymorphism within IL21R confers
risk for systemic lupus erythematosus. Arthritis Rheum 60:2402-2407, 2009. [Abstract]

* Webb R, Wren JD, Jeffries M, Kelly JA, Kaufman KM, Tang Y, Frank MB, Merrill J, Kimberly RP, Edberg JC, Ramsey-Goldman R, Petri M, Reveille JD, Alarcon GS, Vila LM, Alarcón-Riquelme ME, James JA, Vyse TJ, Moser KL, Gaffney PM, Gilkeson GS, Harley JB, Sawalha AH. Variants within MECP2, a key transcription regulator, are associated with increased susceptibility to lupus and differential gene expression in patients with systemic lupus erythematosus. Arthritis Rheum 60:1076-1084, 2009. [Abstract]

Wren JD.  A global meta-analysis of microarray expression data to predict unknown gene functions and estimate the literature-data divide.  Bioinformatics 25:1694-1701, 2009. [Abstract]

Yeliosof O, Scofield RH.  Grid-immunoblotting.  Methods Mol Biol 536:289-292, 2009. [Abstract]

Yin H, Borghi MO, Delgado-Vega AM, Tincani A, Meroni PL, Alarcón-Riquelme ME. Association of STAT4 and BLK, but not BANK1 or IRF5, with primary antiphospholipid syndrome. Arthritis Rheum 60:2468-2471, 2009. [Abstract]

Zhou Y, Yuan J, Pan Y, Fei Y, Qiu X, Hu N, Luo Y, Lei W, Li Y, Long H, Sawalha AH, Richardson B, Lu Q.  T cell CD40LG gene expression and the production of IgG by autologous B cells in systemic lupus erythematosus.  Clin Immunol 132:362-370, 2009. [Abstract]

Cardiovascular Biology Research Program

Barlic J, Zhu W, Murphy PM.  Atherogenic lipids induce high-density lipoprotein uptake and cholesterol efflux in human macrophages by up-regulating transmembrane chemokine CXCL16 without engaging CXCL16-dependent cell adhesion.  J Immunol 182:7928-7936, 2009. [Abstract]

Bezuhly M, Cullen R, Esmon CT, Morris SF, West KA, Johnston B, Liwski RS.  Role of activated protein C and its receptor in inhibition of tumor metastasis.  Blood 113:3371-3374, 2009.[Abstract]

Brooks EG, Trotman W, Wadsworth MP, Taatjes DJ, Evans MF, Ittleman FP, Callas PW, Esmon CT, Bovill EG.   Valves of the deep venous system: an overlooked risk factor.  Blood 114:1276-1279, 2009. [Abstract]

Chesebro BB, Rahn P, Carles M, Esmon CT, Xu J, Brohi K, Frith D, Pittet JF, Cohen MJ.  Increase in activated protein C mediates acute traumatic coagulopathy in mice.  Shock 32:659-665, 2009. [Abstract]

Chichili GR, Rodgers W.  Cytoskeleton-membrane interactions in membrane raft structure.  Cell Mol Life Sci 66:2319-2328, 2009. [Abstract]

Dai S, He Y, Zhang H, Yu L, Wan T, Xu Z, Jones D, Chen H, Min W.  Endothelial-specific expression of mitochondrial thioredoxin promotes ischemia-mediated arteriogenesis and angiogenesis.  Arterioscler Thromb Vasc Biol 29:495-502, 2009. [Abstract]

Delvaeye M, Noris M, De Vriese A., Esmon CT, Esmon NL, Ferrell G, Del-Favero J, Plaisance
S, Claes B, Lambrechts D, Zoja C, Remuzzi G, Conway EM. Thrombomodulin
mutations in atypical hemolytic-uremic syndrome. N Engl J Med 361:345-357, 2009.
[Abstract]

Esmon CT.  Basic mechanisms and pathogenesis of venous thrombosis. Blood Rev 23:225-229, 2009. [Abstract]

Esmon CT.  Dimorphisms in the membrane-spanning domain of EPCR impact systemic coagulation. Arterioscler Thromb Vasc Biol 29:1712-1713, 2009. [Abstract]

Esmon CT, Glass JD.  The APCs of neuroprotection. J Clin Invest 119:3205-3207, 2009. [Abstract]

Fang Y, Wu J, McEver RP, Zhu C.  Bending rigidities of cell surface molecules P-selectin and PSGL-1. J Biomech 42:303-307, 2009. [Abstract]

Finigan JH, Boueiz A, Wilkinson E, Damico R, Skirball J, Pae HH, Damarla M, Hasan E, Pearse DB, Reddy SP, Grigoryev DN, Cheadle C, Esmon CT, Garcia JG, Hassoun PM.  Activated Protein C protects against ventilator-induced pulmonary capillary leak.  Am J Physiol Lung Cell Mol Physiol 296:L1002-L1011, 2009. [Abstract]

Hoffhines AJ, Jen CH, Leary JA, Moore KL.  Tyrosylprotein sulfotransferase-2 expression is required for sulfation of Rnase9 and Mfge8 in Vivo.  J Biol Chem 284:3096-3105, 2009. [Abstract]

Huo Y, Xia L.  P-selectin glycoprotein ligand-1 plays a crucial role in the selective recruitment of leukocytes into the atherosclerotic arterial wall. Trends Cardiovasc Med 19:140-145, 2009. [Abstract]

* Izmirly PM, Barisoni L, Buyon JP, Kim MY, Rivera TL, Schwartzman JS, Weisstuch JM, Liu DT, Bernstein S, Tseng CE, Belmont HM, Esmon CT, Merrill JT, Askanase AD, Thomas DB, Clancy RM.  Expression of endothelial protein C receptor in cortical peritubular capillaries associates with a poor clinical response in lupus nephritis.  Rheumatology (Oxford) 48:513-519,  2009. [Abstract]

Jen CH, Moore KL, Leary JA. Pattern and temporal sequence of sulfation of CCR5 N-terminal peptides by tyrosylprotein sulfotransferase-2: an assessment of the effects of N-terminal residues. Biochemistry 48:5332-5338, 2009. [Abstract]

Li Z, Wells CW, Esmon CT, Zhao M.  Phosphatidylethanolamine at the endothelial surface of aortic flow dividers.  J Thromb Haemost 7:227-229, 2009. [Abstract]

Looney MR, Esmon CT, Matthay MA.  Role of coagulation pathways and treatment with activated protein C in hyperoxic lung injury.  Thorax 64:114-120, 2009.[Abstract]

Loubele ST, Spek CA, Leenders P, van Oerle R, Aberson HL, Hamulyák K, Ferrell G, Esmon CT, Spronk HM, Ten Cate H.  Activated protein C protects against myocardial ischemia/reperfusion injury via inhibition of apoptosis and inflammation.  Arterioscler Thromb Vasc Biol 20:1087-1092, 2009. [Abstract]

Mehta P.  Semi-dry protein transfer and immunodetection of P-Selectin using an antibody to its C-terminal tag.  Methods Mol Biol 536:229-235, 2009. [Abstract]

Moore KL. Protein tyrosine sulfation: a critical posttranslation modification in plants and animals. Proc Natl Acad Sci U S A 106:14741-14742, 2009. [Abstract]

Motose H, Iwamoto K, Endo S, Demura T, Sakagami Y, Matsubayashi Y, Moore KL, Fukuda H.  Involvement of phytosulfokine in the attenuation of stress response during the transdifferentiation of zinnia mesophyll cells into tracheary elements. Plant Physiol 150:437-447, 2009. [Abstract]

Nayak RC, Sen P, Ghosh S, Gopalakrishnan R, Esmon CT, Pendurthi UR, Rao LV.  Endothelial cell protein C receptor cellular localization and trafficking. Blood 114:1974-1986, 2009. [Abstract]

Smyth SS, McEver RP, Weyrich AS, Morrell CN, Hoffman MR, Arepally GM, French PA, Dauerman HL, Becker RC, 2009 Platelet Colloquim Participants.  Platelet functions beyond haemostasis. J Thromb Haemost 7:1759-1766, 2009. [Abstract]

Stowell SR, Cho M, Feasley CL, Arthur CM, Song X, Colucci JK, Karmakar S, Mehta P, Dias-Baruffi M, McEver RP, Cummings RD.  Ligand reduces galectin-1 sensitivity to oxidative inactivation by enhancing dimer formation.  J Biol Chem 284:4989-4999, 2009. [Abstract]

Stowell SR, Karmakar S, Arthur CM, Ju T, Rodrigues LC, Riul TB, Dias-Baruffi M, Miner J, McEver RP, Cummings RD.  Galectin-1 induces reversible phosphatidylserine exposure at the plasma membrane.  Mol Biol Cell 20:1408-1418,  2009. [Abstract]

* Towner RA, Smith N, Doblas S, Garteiser P, Watanabe Y, He T, Saunders D, Herlea O, Silasi-Mansat R, Lupu F.  In Vivo detection of inducible nitric oxide xynthase (iNOS) in rodent gliomas. Free Radic Biol Med 2009. [Abstract]

Van Sluis GL, Niers TM, Esmon CT, Tigchelaar W, Richel DJ, Buller HR, Van Noorden CJ, Spek CA.  Endogenous activated protein C limits cancer cell extravasation through sphingosine-1-phosphate receptor 1-mediated vascular endothelial barrier enhancement. Blood 114:1968-1973, 2009. [Abstract]

Wang H, Tang R, Zhang W, Amirikian K, Geng Z, Geng J, Hebbel RP, Xia L, Marth JD, Fukuda M, Katoh S, Huo Y.  Core2 1-6-N-glucosaminyltransferase-I is crucial for the formation of atherosclerotic lesions in apolipoprotein E-deficient mice.  Arterioscler Thromb Vasc Biol 29:180-187, 2009. [Abstract]

Westmuckett AD, Moore KL.  Lack of tyrosylprotein sulfotransferase activity in hematopoietic cells drastically attenuates atherosclerosis in Ldlr-/- mice. Arterioscler Thromb Vasc Biol 29:1730-1736, 2009. [Abstract]

Xu J, Ji Y, Zhang X, Drake M, Esmon CT.  Endogenous activated protein C signaling is critical to protection of mice from lipopolysaccaride-induced septic shock.  J Thromb Haemost 7:851-856,  2009. [Abstract]

Xu J, Zhang X, Pelayo R, Monestier M, Ammollo CT, Semeraro F, Taylor FB, Esmon NL, Lupu F, Esmon CT.  Extracellular histones are major mediators of death in sepsis. Nat Med 15:1318-1321, 2009. [Abstract]

Yu L, Min W, He Y, Qin L, Zhang H, Bennett AM, Chen H.  JAK2 and SHP2 reciprocally regulate tyrosine phosphorylation and stability of proapoptotic protein ASK1. J Biol Chem 284:13481-13488, 2009. [Abstract]

Cell Cycle and Cancer Biology Research Program

Daum JR, Mo YY, Gorbsky GJ.  The Dynamics of DNA topoisomerase IIalpha in living cells. Methods Mol Biol 582:233-244, 2009. [Abstract]

* Daum JR, Wren JD, Daniel JJ, Sivakumar S, McAvoy JN, Potapova TA, Gorbsky GJ. Ska3 is
required for spindle checkpoint silencing and the maintenance of chromosome cohesion
in mitosis. Curr Biol 19:1467-1472, 2009.[Abstract]

Demoe JH, Santaguida S, Daum JR, Musacchio A, Gorbsky GJ.  A High throughput, whole cell screen for small molecule inhibitors of the mitotic spindle checkpoint identifies OM137, a novel aurora kinase inhibitor.  Cancer Res 69:1509-1516, 2009. [Abstract]

Dresser ME.  Time-lapse fluorescence microscopy of Saccharomyces cerevisiae in meiosis. Methods Mol Biol 558:65-79, 2009. [Abstract]

Gladstone MN, Obeso D, Chuong H, Dawson DS.  The synaptonemal complex protein Zip1 promotes bi-orientation of centromeres at meiosis I. PLoS Genet 5:e1000771, 2009. [Abstract]

Hu L, Plafker K, Vorozhko V, Zuna RE, Hanigan MH, Gorbsky GJ, Plafker SM, Angeletti PC, Ceresa BP.  Human papillomavirus 16 E5 induces bi-nucleated cell formation by cell-cell fusion. Virology 384:125-134, 2009. [Abstract]

Knowlton AL, Vorozhko VV, Lan W, Gorbsky GJ, Stukenberg PT.  ICIS and Aurora B coregulate the microtubule depolymerase Kif2a.  Curr Biol 19:758-763, 2009. [Abstract]

Potapova TA, Daum JR, Byrd KS, Gorbsky GJ.   Fine tuning the cell cycle: activation of the Cdk1 inhibitory phosphorylation pathway during mitotic exit.  Mol Biol Cell 20:1737-1748, 2009. [Abstract]

Salmela AL, Pouwels J, Varis A, Kukkonen A, Toivonen P, Halonen P, Perälä M, Kallioniemi O, Gorbsky GJ, Kallio MJ.  Dietary flavonoid fisetin induces a forced exit from mitosis by targeting the mitotic spindle checkpoint.  Carcinogenesis 30:1032-1040, 2009. [Abstract]

Clinical Immunology Research Program

* Bates JS, Lessard CJ, Leon JM, Nguyen T, Battiest LJ, Rodgers J, Kaufman KM, James JA, Gilkeson GS, Kelly JA, Humphrey MB, Harley JB, Gray-McGuire C, Moser KL, Gaffney PM. Meta-analysis and imputation identifies a 109 kb risk haplotype spanning TNFAIP3 associated with lupus nephritis and hematologic manifestations. Genes Immun 10:470-477, 2009. [Abstract]

* Douglas KB, Windels DC, Zhao J, Gadeliya AV, Wu H, Kaufman KM, Harley JB, Merrill J, Kimberly RP, Alarcon GS, Brown EE, Edberg JC, Ramsey-Goldman R, Petri M, Reveille JD, Vila LM, Gaffney PM, James JA, Moser KL, Alarcón-Riquelme ME, Vyse TJ, Gilkeson GS, Jacob CO, Ziegler JT, Langefeld CD, Ulgiati D, Tsao BP, Boackle SA. Complement receptor 2 polymorphisms associated with systemic lupus erythematosus modulate alternative splicing. Genes Immun 10:457-469, 2009. [Abstract]

* Feng J, Gulati U, Zhang X, Keitel WA, Thompson DM, James JA, Thompson LF, Air GM.  Antibody quantity versus quality after influenza vaccination. Vaccine 27:6358-6362, 2009. [Abstract]

* Guo L, Deshmukh H, Lu R, Vidal GS, Kelly JA, Kaufman KM, Dominguez N, Klein W, Kim-Howard X, Bruner GR, Scofield RH, Moser KL, Gaffney PM, Dozmorov IM, Gilkeson GS, Wakeland EK, Li QZ, Langefeld CD, Marion MC, Williams AH, Divers J, Alarcon GS, Brown EE, Kimberly RP, Edberg JC, Ramsey-Goldman R, Reveille JD, McGwin G, Jr., Vila LM, Petri MA, Vyse TJ, Merrill JT, James JA, Nath SK, Harley JB, Guthridge JM. Replication of the BANK1 genetic association with systemic lupus erythematosus in a European-derived population. Genes Immun 10:531-538, 2009. [Abstract]

* Han S, Kim-Howard X, Deshmukh H, Kamatani Y, Viswanathan P, Guthridge JM, Thomas K, Kaufman KM, Ojwang J, Rojas-Villarraga A, Baca V, Orozco L, Rhodes B, Choi CB, Gregersen PK, Merrill JT, James JA, Gaffney PM, Moser KL, Jacob CO, Kimberly RP, Harley JB, Bae SC, Anaya JM, Alarcón-Riquelme ME, Matsuda K, Vyse TJ, Nath SK.  Evaluation of imputation-based association in and around the integrin-{alpha}-M (ITGAM) gene replication of robust association between a non-synonymous functional variant within ITGAM and systemic lupus erythematosus (SLE).  Hum Mol Genet 18:1171-1180, 2009. [Abstract]

Jackson SM, Harp N, Patel D, Wulf J, Spaeth ED, Dike UK, James JA, Capra JD. Key developmental transitions in human germinal center B cells are revealed by differential CD45RB expression. Blood 113:3999-4007, 2009. [Abstract]

* Namjou B, Gray-McGuire C, Sestak AL, Gilkeson GS, Jacob CO, Merrill JT, James JA, Wakeland EK, Li QZ, Langefeld CD, Divers J, Ziegler J, Moser KL, Kelly JA, Kaufman KM, Harley JB.   Evaluation of C1q genomic region in minority racial groups of lupus. Genes Immun 10:517-524, 2009. [Abstract]

* Namjou B, Sestak AL, Armstrong DL, Zidovetzki R, Kelly JA, Jacob N, Ciobanu V, Kaufman KM, Ojwang JO, Ziegler J, Quismorio FP, Jr., Reiff A, Myones BL, Guthridge JM, Nath SK, Bruner GR, Mehrian-Shai R, Silverman E, Klein-Gitelman M, McCurdy D, Wagner-Weiner L, Nocton JJ, Putterman C, Bae SC, Kim YJ, Petri M, Reveille JD, Vyse TJ, Gilkeson GS, Kamen DL, Alarcón-Riquelme ME, Gaffney PM, Moser KL, Merrill JT, Scofield RH, James JA, Langefeld CD, Harley JB, Jacob CO.  High-density genotyping of STAT4 reveals multiple haplotypic associations with systemic lupus erythematosus in different racial groups.  Arthritis Rheum 60:1085-1095, 2009. [Abstract]

* Nguyen ML, Crowe SR, Kurella S, Teryzan S, Cao B, Ballard JD, James JA, Farris AD.  Sequential B-cell epitopes of Bacillus anthracis lethal factor bind lethal toxin-neutralizing antibodies.  Infect Immun 77:162-169, 2009. [Abstract]

* Nguyen ML, Terzyan S, Ballard JD, James JA, Farris AD.  The Major neutralizing antibody responses to recombinant anthrax lethal factor and edema factors are directed to non-cross-reactive epitopes. Infect Immun 77:4714-4723, 2009. [Abstract]

* Poole BD, Schneider RI, Guthridge JM, Velte CA, Reichlin M, Harley JB, James JA.  Early targets of nuclear RNP humoral autoimmunity in human systemic lupus erythematosus.  Arthritis Rheum 60:848-859, 2009. [Abstract]

* Poole BD, Templeton AK, Guthridge JM, Brown EJ, Harley JB, James JA.  Aberrant Epstein-Barr viral infection in systemic lupus erythematosus.  Autoimmun Rev 8:337-342, 2009. [Abstract]

* Webb R, Wren JD, Jeffries M, Kelly JA, Kaufman KM, Tang Y, Frank MB, Merrill J, Kimberly RP, Edberg JC, Ramsey-Goldman R, Petri M, Reveille JD, Alarcon GS, Vila LM, Alarcón-Riquelme ME, James JA, Vyse TJ, Moser KL, Gaffney PM, Gilkeson GS, Harley JB, Sawalha AH.  Variants within MECP2, a key transcription regulator, are associated with increased susceptibility to lupus and differential gene expression in patients with systemic lupus erythematosus.  Arthritis Rheum 60:1076-1084, 2009. [Abstract]

Yin H, Borghi MO, Delgado-Vega AM, Tincani A, Meroni PL, Alarcón-Riquelme ME.
Association of STAT4 and BLK, but not BANK1 or IRF5, with primary antiphospholipid
syndrome. Arthritis Rheum 60:2468-2471, 2009. [Abstract]

Clinical Pharmacology Research Program

* Armstrong DL, Reiff A, Myones BL, Quismorio FP, Jr., Klein-Gitelman M, McCurdy D, Wagner-Weiner L, Silverman E, Ojwang JO, Kaufman KM, Kelly JA, Merrill JT, Harley JB, Bae SC, Vyse TJ, Gilkeson GS, Gaffney PM, Moser KL, Putterman C, Edberg JC, Brown EE, Ziegler J, Langefeld CD, Zidovetzki R, Jacob CO.   Identification of new SLE-associated genes with a two-step Bayesian study design. Genes Immun 10:446-456, 2009. [Abstract]

Furie RA, Petri MA, Wallace DJ, Ginzler EM, Merrill JT, Stohl W, Chatham WW, Strand V, Weinstein A, Chevrier MR, Zhong ZJ, Freimuth WW.  Novel evidence-based systemic lupus erythematosus responder index. Arthritis Rheum 61:1143-1151, 2009. [Abstract]

Gladd DA, Olech E.  Antiphospholipid antibodies in rheumatoid arthritis: identifying the dominoes. Curr Rheumatol Rep 11:43-51, 2009. [Abstract]

* Guo L, Deshmukh H, Lu R, Vidal GS, Kelly JA, Kaufman KM, Dominguez N, Klein W, Kim-Howard X, Bruner GR, Scofield RH, Moser KL, Gaffney PM, Dozmorov IM, Gilkeson GS, Wakeland EK, Li QZ, Langefeld CD, Marion MC, Williams AH, Divers J, Alarcon GS, Brown EE, Kimberly RP, Edberg JC, Ramsey-Goldman R, Reveille JD, McGwin G, Jr., Vila LM, Petri MA, Vyse TJ, Merrill JT, James JA, Nath SK, Harley JB, Guthridge JM. Replication of the BANK1 genetic association with systemic lupus erythematosus in a European-derived population. Genes Immun 10:531-538, 2009. [Abstract]

* Han S, Kim-Howard X, Deshmukh H, Kamatani Y, Viswanathan P, Guthridge JM, Thomas K, Kaufman KM, Ojwang J, Rojas-Villarraga A, Baca V, Orozco L, Rhodes B, Choi CB, Gregersen PK, Merrill JT, James JA, Gaffney PM, Moser KL, Jacob CO, Kimberly RP, Harley JB, Bae SC, Anaya JM, Alarcón-Riquelme ME, Matsuda K, Vyse TJ, Nath SK.  Evaluation of imputation-based association in and around the integrin-{alpha}-M (ITGAM) gene replication of robust association between a non-synonymous functional variant within ITGAM and systemic lupus erythematosus (SLE).  Hum Mol Genet 18:1171-1180, 2009. [Abstract]

* Izmirly PM, Barisoni L, Buyon JP, Kim MY, Rivera TL, Schwartzman JS, Weisstuch JM, Liu DT, Bernstein S, Tseng CE, Belmont HM, Esmon CT, Merrill JT, Askanase AD, Thomas DB, Clancy RM.  Expression of endothelial protein C receptor in cortical peritubular capillaries associates with a poor clinical response in lupus nephritis.  Rheumatology (Oxford), 48:513-519,  2009. [Abstract]

* Jacob CO, Zhu J, Armstrong DL, Yan M, Han J, Zhou XJ, Thomas JA, Reiff A, Myones BL, Ojwang JO, Kaufman KM, Klein-Gitelman M, McCurdy D, Wagner-Weiner L, Silverman E, Ziegler J, Kelly JA, Merrill JT, Harley JB, Ramsey-Goldman R, Vila LM, Bae SC, Vyse TJ, Gilkeson GS, Gaffney PM, Moser KL, Langefeld CD, Zidovetzki R, Mohan C.  Identification of IRAK1 as a risk gene with critical role in the pathogenesis of systemic lupus erythematosus.  Proc Natl Acad Sci U S A 106:6256-6261, 2009. [Abstract]

Kalunian K, Merrill JT.  New directions in the treatment of systemic lupus erythematosus. Curr Med Res Opin 25:1501-1514, 2009.

* Liu K, Li QZ, Delgado-Vega AM, Abelson AK, Sanchez E, Kelly JA, Li L, Liu Y, Zhou J, Yan M, Ye Q, Liu S, Xie C, Zhou XJ, Chung SA, Pons-Estel B, Witte T, de RE, Bae SC, Barizzone N, Sebastiani GD, Merrill JT, Gregersen PK, Gilkeson GG, Kimberly RP, Vyse TJ, Kim I, D’Alfonso S, Martin J, Harley JB, Criswell LA, Wakeland EK, Alarcón-Riquelme ME, Mohan C, Profile Study Group, Italian Collaborative Group, German Collaborative Group, Spanish Collaborative Group, Argentinian Collaborative Group, SLEGEN Consortium.  Kallikrein genes are associated with lupus and glomerular basement membrane-specific antibody-induced nephritis in mice and humans.  J Clin Invest 119:911-923, 2009. [Abstract]

* Lu R, Vidal GS, Kelly JA, Delgado-Vega AM, Howard XK, Macwana SR, Dominguez N, Klein W, Burrell C, Harley IT, Kaufman KM, Bruner GR, Moser KL, Gaffney PM, Gilkeson GS, Wakeland EK, Li QZ, Langefeld CD, Marion MC, Divers J, Alarcon GS, Brown EE, Kimberly RP, Edberg JC, Ramsey-Goldman R, Reveille JD, McGwin JG, Vila LM, Petri MA, Bae SC, Cho SK, Bang SY, Kim I, Choi CB, Martin J, Vyse TJ, Merrill JT, Harley JB, Alarcón-Riquelme ME, for the BIOLUPUS and GENLES Multicenter Collaborations, Nath SK, James JA, Guthridge JM. Genetic associations of LYN with systemic lupus erythematosus. Genes Immun 10:397-403, 2009. [Abstract]

Merrill JT. Clinical trials for lupus–are we there yet? Bull NYU Hosp Jt Dis 67:267-270, 2009. [Abstract]

Merrill JT, Buyon JP.  Connective tissue diseases: what does the death of Riquent hold for the future of SLE? Nat Rev Rheumatol 5:306-307, 2009.  [Abstract]

* Namjou B, Gray-McGuire C, Sestak AL, Gilkeson GS, Jacob CO, Merrill JT, James JA, Wakeland EK, Li QZ, Langefeld CD, Divers J, Ziegler J, Moser KL, Kelly JA, Kaufman KM, Harley JB.   Evaluation of C1q genomic region in minority racial groups of lupus. Genes Immun 10:517-524, 2009. [Abstract]

* Namjou B, Sestak AL, Armstrong DL, Zidovetzki R, Kelly JA, Jacob N, Ciobanu V, Kaufman KM, Ojwang JO, Ziegler J, Quismorio FP, Jr., Reiff A, Myones BL, Guthridge JM, Nath SK, Bruner GR, Mehrian-Shai R, Silverman E, Klein-Gitelman M, McCurdy D, Wagner-Weiner L, Nocton JJ, Putterman C, Bae SC, Kim YJ, Petri M, Reveille JD, Vyse TJ, Gilkeson GS, Kamen DL, Alarcón-Riquelme ME, Gaffney PM, Moser KL, Merrill JT, Scofield RH, James JA, Langefeld CD, Harley JB, Jacob CO.  High-density genotyping of STAT4 reveals multiple haplotypic associations with systemic lupus erythematosus in different racial groups.  Arthritis Rheum 60:1085-1095, 2009. [Abstract]

Reiss AB, Wan DW, Anwar K, Merrill JT, Wirkowski PA, Shah N, Cronstein BN, Chan ES, Carsons SE.  Enhanced CD36 scavenger receptor expression in THP-1 human monocytes in the presence of lupus plasma: linking autoimmunity and atherosclerosis.  Exp Biol Med (Maywood ) 234:354-360, 2009. [Abstract]

Wallace DJ, Stohl W, Furie RA, Lisse JR, McKay JD, Merrill JT, Petri MA, Ginzler EM, Chatham WW, McCune WJ, Fernandez V, Chevrier MR, Zhong ZJ, Freimuth WW.  A phase II, randomized, double-blind, placebo-controlled, dose-ranging study of belimumab in patients with active systemic lupus erythematosus. Arthritis Rheum 61:1168-1178, 2009. [Abstract]

* Webb R, Merrill JT, Kelly JA, Sestak A, Kaufman KM, Langefeld CD, Ziegler J, Kimberly RP, Edberg JC, Ramsey-Goldman R, Petri M, Reveille JD, Alarcon GS, Vila LM, Alarcón-Riquelme ME, James JA, Gilkeson GS, Jacob CO, Moser KL, Gaffney PM, Vyse TJ, Nath SK, Lipsky P, Harley JB, Sawalha AH. A polymorphism within IL21R confers
risk for systemic lupus erythematosus. Arthritis Rheum 60:2402-2407, 2009. [Abstract]

* Webb R, Wren JD, Jeffries M, Kelly JA, Kaufman KM, Tang Y, Frank MB, Merrill J, Kimberly RP, Edberg JC, Ramsey-Goldman R, Petri M, Reveille JD, Alarcon GS, Vila LM, Alarcón-Riquelme ME, James JA, Vyse TJ, Moser KL, Gaffney PM, Gilkeson GS, Harley JB, Sawalha AH.  Variants within MECP2, a key transcription regulator, are associated with increased susceptibility to lupus and differential gene expression in patients with systemic lupus erythematosus.  Arthritis Rheum 60:1076-1084, 2009. [Abstract]

Comparative Medicine

Gruber HE, Gordon B, Williams C, Ingram JA, Norton HJ, Hanley EN, Jr.  A new small animal model for the study of spine fusion in the sand rat: pilot studies.  Lab Anim 43:272-277, 2009. [Abstract]

Experimental Therapeutics Research Laboratory

Floyd RA.   Serendipitous findings while researching oxygen free radicals.  Free Radic Biol Med 46:1004-1013, 2009. [Abstract]

* Griffitts J, Tesiram YA, Reid GE, Saunders D, Floyd RA, Towner RA. In vivo magnetic resonance spectroscopy (MRS) assessment of altered fatty acyl unsaturation in liver tumor formation of a TGFalpha /c-myc transgenic mouse model.  J Lipid Res  50:611-622, 2009. [Abstract]

Free Radical Biology and Aging Research Program

Allen KD, Griffin TM, Rodriguiz RM, Wetsel WC, Kraus VB, Huebner JL, Boyd LM, Setton LA.  Decreased physical function and increased pain sensitivity in mice deficient for type IX collagen. Arthritis Rheum 60:2684-2693, 2009. [Abstract]

Arendash GW, Cox AA, Mori T, Cracchiolo JR, Hensley KL, Roberts JL. Oxygen treatment triggers cognitive impairment in Alzheimer’s transgenic mice. Neuroreport 20:1087-1092, 2009. [Abstract]

* Gomez-Mejiba SE, Zhai Z, Akram H, Deterding LJ, Hensley K, Smith N, Towner RA, Tomer KB, Mason RP, Ramirez DC.  Immuno-spin trapping of protein and DNA radicals: “tagging” free radicals to locate and understand the redox process.  Free Radic Biol Med 46:853-65, 2009. [Abstract]

* Gomez-Mejiba SE, Zhai Z, Akram H, Pye QN, Hensley K, Kurien BT, Scofield RH, Ramirez DC.  Inhalation of environmental stressors and chronic inflammation: autoimmunity and neurodegeneration.  Mutat Res 674:62-72, 2009. [Abstract]

Griffin TM, Huebner JL, Kraus VB, Guilak F.  Extreme obesity due to impaired leptin signaling in mice does not cause knee osteoarthritis. Arthritis Rheum 60:2935-2944, 2009. [Abstract]

Grozav AG, Chikamori K, Kozuki T, Grabowski DR, Bukowski RM, Willard B, Kinter M, Andersen AH, Ganapathi R, Ganapathi MK.  Casein kinase I {delta}/{varepsilon} phosphorylates topoisomerase II{alpha} at serine-1106 and modulates DNA cleavage activity.  Nucleic Acids Res 37:382-392, 2009. [Abstract]

Hensley K.  Detection of protein carbonyls by means of biotin hydrazide-streptavidin affinity methods.  Methods Mol Biol 536:457-462, 2009. [Abstract]

Hensley K.  The Importance of getting a good start: gestational nutrition interacts with adult nutrition to affect function of the aging brain.  Neurobiol Dis 35:1-2, 2009. [Abstract]

Humphries KM.  Mitochondrial superoxide production and respiratory activity: biphasic response to ischemic duration.  Arch Biochem Biophys 484:87-93, 2009. [Abstract]

Koeck T, Willard B, Crabb JW, Kinter M, Stuehr DJ, Aulak KS.  Glucose-mediated tyrosine nitration in adipocytes: targets and consequences.  Free Radic Biol Med 46:884-892, 2009. [Abstract]

Kojima C, Ramirez DC, Tokar EJ, Himeno S, Drobná Z, Stýblo M, Mason RP, Waalkes MP.  Requirement of arsenic biomethylation for oxidative DNA damage. J Natl Cancer Inst 101:1670-1681, 2009. [Abstract]

Matsuzaki S, Szweda LI, Humphries KM.  Mitochondrial superoxide production and respiratory activity: biphasic response to ischemic duration.  Arch Biochem Biophys 484:87-93, 2009. [Abstract]

Matsuzaki S, Szweda PA, Szweda LI, Humphries KM.  Regulated production of free radicals by the mitochondrial electron transport chain: cardiac ischemic preconditioning. Adv Drug Deliv Rev 2009. [Abstract]

Moser MD, Matsuzaki S, Humphries KM.  Inhibition of succinate-linked respiration and complex II activity by hydrogen peroxide.   Arch Biochem Biophys 488:69-75, 2009. [Abstract]

Neymotin A, Petri S, Calingasan NY, Wille E, Schafer P, Stewart C, Hensley K, Beal MF, Kiaei M.  Lenalidomide (Revlimid) administration at symptom onset is neuroprotective in a mouse model of amyotrophic lateral sclerosis. Exp Neurol 220:191-197, 2009. [Abstract]

Ramirez DC, Gomez-Mejiba SE, Corbett JT, Deterding LJ, Tomer KB, Mason RP.  Cu,Zn-superoxide dismutase-driven free radical modifications: copper- and carbonate radical anion-initiated protein radical chemistry.  Biochem J 417:341-353, 2009. [Abstract]

Zhang W, Wang L, Liu Y, Xu J, Zhu G, Cang H, Li X, Bartlam M, Hensley K, Li G, Rao Z, Zhang XC. Structure of human lanthionine synthetase C-like protein 1 and its interaction with Eps8 and glutathione. Genes Dev 23:1387-1392, 2009. [Abstract]

Ziady AG, Kinter M.  Protein sequencing with tandem mass spectrometry.  Methods Mol Biol 544:325-341, 2009. [Abstract]

Genetic Models of Disease Research Program

Edwards SL, Charlie NK, Richmond JE, Hegermann J, Eimer S, Miller KG.  Impaired dense core vesicle maturation in Caenorhabditis elegans mutants lacking Rab2. J Cell Biol 186:881-895, 2009. [Abstract]

Hovel-Miner G, Pampou S, Faucher SP, Clarke M, Morozova I, Morozov P, Russo JJ, Shuman HA, Kalachikov S.  {sigma}S controls multiple pathways associated with intracellular multiplication of Legionella pneumophila.  J Bacteriol 191:2461-2473, 2009. [Abstract]

Silverman PM.  The research dynamic: a professional development model for secondary school science teachers.  CBE Life Sci Educ 8:123-130, 2009. [Abstract]

Wang YA, Yu X, Silverman PM, Harris RL, Egelman EH.  The structure of F-pili. J Mol Biol 385:22-29, 2009. [Abstract]

Immunobiology and Cancer Research Program

Chen X, Welner RS, Kincade PW.  A possible contribution of retinoids to regulation of fetal B lymphopoiesis. Eur J Immunol 39:2515-2524, 2009. [Abstract]

Cochrane SW, Zhao Y, Welner RS, Sun XH.  Balance between Id and E proteins regulates myeloid-versus-lymphoid lineage decisions.  Blood 113:1016-1026, 2009. [Abstract]

Dozmorov M, Wu W, Chakrabarty K, Booth JL, Hurst RE, Coggeshall KM, Metcalf JP.  Gene expression profiling of human alveolar macrophages infected by B. anthracis spores demonstrates TNF-alpha and NF-kappab are key components of the innate immune response to the pathogen. BMC Infect Dis 9:152, 2009. [Abstract]

Dudley DD, Wang HC, Sun XH.  Hes1 potentiates T cell lymphomagenesis by up-regulating a subset of notch target genes. PLoS ONE 4:e6678, 2009. [Abstract]

Esplin BL, Welner RS, Zhang Q, Borghesi LA, Kincade PW.  A differentiation pathway for B1 cells in adult bone marrow.  Proc Natl Acad Sci U S A 106:5773-5778, 2009. [Abstract]

* Feng J, Gulati U, Zhang X, Keitel WA, Thompson DM, James JA, Thompson LF, Air GM.  Antibody quantity versus quality after influenza vaccination. Vaccine 27:6358-6362, 2009. [Abstract]

* Maeda K, Malykhin A, Teague-Weber BN, Sun XH, Farris AD, Coggeshall KM.  Interleukin 6 aborts lymphopoiesis and elevates production of myeloid cells in systemic lupus erythematosis-prone B6. Sle1.Yaa animals. Blood 113:4534-4540, 2009. [Abstract]

Malhotra S, Kincade PW.  Canonical Wnt pathway signaling suppresses VCAM-1 expression by marrow stromal and hematopoietic cells.  Exp Hematol 37:19-30, 2009. [Abstract]

Malhotra S, Kincade PW.  Wnt-related molecules and signaling pathway equilibrium in hematopoiesis.  Cell Stem Cell 4:27-36, 2009. [Abstract]

* Malhotra S, Kovats S, Zhang W, Coggeshall KM. B cell antigen receptor endocytosis and antigen presentation to T cells requires Vav and dynamin. J Biol Chem 284:24088-24097, 2009. [Abstract]

* Malhotra S, Kovats S, Zhang W, Coggeshall KM.  Vav and Rac activation in B cell antigen receptor endocytosis involves Vav recruitment to the adapter protein LAB. J Biol Chem 284:36202-36212, 2009. [Abstract]

Mehta H, Glogauer M, Bécart S, Altman A, Coggeshall KM.  Adaptor protein SLAT modulates Fcgamma receptor-mediated phagocytosis in murine macrophages.  J Biol Chem 294:11882-11891, 2009. [Abstract]

Schmidt C, Kim D, Ippolito GC, Naqvi HR, Probst L, Mathur S, Rosas-Acosta G, Wilson VG, Oldham AL, Poenie M, Webb CF, Tucker PW.  Signalling of the BCR is regulated by a lipid rafts-localised transcription factor, Bright. EMBO J 28:711-724, 2009. [Abstract]

Wang HC, Perry SS, Sun XH.  Id1 attenuates Notch signaling and impairs T-cell commitment by elevating Deltex1 expression. Mol Cell Biol 29:4640-4652, 2009. [Abstract]

Welner RS, Esplin BL, Garrett KP, Pelayo R, Luche H, Fehling HJ, Kincade PW.  Asynchronous RAG-1 expression during B lymphopoiesis. J Immunol 183:7768-7777, 2009. [Abstract]

Wilson NK, Miranda-Saavedra D, Kinston S, Bonadies N, Foster SD, Calero-Nieto F, Dawson MA, Donaldson IJ, Dumon S, Frampton J, Janky R, Sun XH, Teichmann SA, Bannister AJ, Gottgens B.  The transcriptional program controlled by the stem cell leukaemia gene Scl/Tal1 during early embryonic haematopoietic development.  Blood 113:5456-5465, 2009. [Abstract]

Wu W, Mehta H, Chakrabarty K, Booth JL, Duggan ES, Patel KB, Ballard JD, Coggeshall KM, Metcalf JP.  Resistance of human alveolar macrophages to Bacillus anthracis lethal toxin. J Immunol 183:5799-5806, 2009. [Abstract]

Yokota T, Oritani K, Butz S, Kokame K, Kincade PW, Miyata T, Vestweber D, Kanakura Y.  The endothelial antigen ESAM marks primitive hematopoietic progenitors throughout life in mice.  Blood 113:2914-2923, 2009. [Abstract]

Lipid Studies

Bagdade J, Knight-Gibson C, Quiroga C, Jacobson M, Lee D.  Distribution of immunochemically defined apoB-containing lipoprotein subclasses in T1D. Diabetes Res Clin Pract 85:265-271, 2009. [Abstract]

Hodis HN, Mack WJ, Dustin L, Mahrer PR, Azen SP, Detrano R, Selhub J, Alaupovic P, Liu CR, Liu CH, Hwang J, Wilcox AG, Selzer RH, BVAIT Research Group.  High-dose B vitamin supplementation and progression of subclinical atherosclerosis.  A randomized controlled trial.  Stroke 40:730-736, 2009. [Abstract]

Sacks FM, Rudel LL, Conner A, Akeefe H, Kostner G, Baki T, Rothblat G, de la Llera-Moya M, Asztalos B, Perlman T, Zheng C, Alaupovic P, Maltais JA, Brewer HB.  Selective delipidation of plasma HDL enhances reverse cholesterol transport in vivo.  J Lipid Res 50:894-907, 2009. [Abstract]

Protein Studies Research Program

Ghosh AK, Kulkarni S, Anderson DD, Hong L, Baldridge A, Wang YF, Chumanevich AA, Kovalevsky AY, Tojo Y, Amano M, Koh Y, Tang J, Weber IT, Mitsuya H. Design, synthesis, protein-ligand X-ray structure, and biological evaluation of a series of novel macrocyclic human immunodeficiency virus-1 protease inhibitors to combat drug resistance. J Med Chem 52:7689-7705, 2009. [Abstract]

Lee KN, Jackson KW, Terzyan S, Christiansen VJ, McKee PA.  Using substrate specificity of antiplasmin-cleaving enzyme for fibroblast activation protein inhibitor design. Biochemistry 48:5149-5158, 2009. [Abstract]

Liu XQ, Xu LF, Liu YW, Tong XH, Zhu GY, Zhang XJ, Li XM, Rao ZH.  Crystal structure of the hexamer of human heat shock factor binding protein 1. Proteins 75:1-11, 2009.

Minogue AM, Stubbs AK, Frigerio CS, Boland B, Fadeeva JV, Tang J, Selkoe DJ, Walsh DM.  gamma-secretase processing of APLP1 leads to the production of a p3-like peptide that does not aggregate and is not toxic to neurons.  Brain Res 1262:89-99, 2009. [Abstract]

* Nguyen ML, Crowe SR, Kurella S, Teryzan S, Cao B, Ballard JD, James JA, Farris AD. Sequential B-cell epitopes of Bacillus anthracis lethal factor bind lethal toxin-neutralizing antibodies. Infect Immun 77:162-169, 2009. [Abstract]

* Nguyen ML, Terzyan S, Ballard JD, James JA, Farris AD.  The Major neutralizing antibody responses to recombinant anthrax lethal factor and edema factors are directed to non-cross-reactive epitopes. Infect Immun 77:4714-4723, 2009. [Abstract]

* Indicates publications by more than one department.

04/08/10
 

Additional Publications:
2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 2000