The Protein Studies Research Program, under the direction of Jordan Tang, Ph.D., is interested in the structure and function of several biomedically important aspartic proteases. Historically, this program contributed to the basic structure-function model of aspartic proteases and their inhibition.

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    Jordan J.N. Tang, Ph.D.
    Member and Program Chair

2011

Chang WP, Huang X, Downs D, Cirrito JR, Koelsch G, Holtzman DM, Ghosh AK, Tang J. β-Secretase inhibitor GRL-8234 rescues age-related cognitive decline in APP transgenic mice. FASEB J 25:775-784, 2011. [Abstract]

Li F, Terzyan S, Tang J. Subsite specificity of anthrax lethal factor and its implications for inhibitor development. Biochem Biophys Res Commun 407:400-405, 2011. [Abstract]

Tang J, Ghosh A. Treating transgenic Alzheimer mice with a β-secretase inhibitor, what have we learned? Aging (Albany NY) 3:14-16, 2011. [Abstract]

2012

Ghosh AK, Brindisi M, Tang J. Developing ß-secretase inhibitors for treatment of Alzheimer’s disease. J Neurochem 120 Suppl 1:71-83, 2012. [Abstract]

Li F, Chvyrkova I, Terzyan S, Wakeham N, Turner R, Ghosh AK, Zhang XC, Tang J. Inhibition of anthrax lethal factor: lability of hydroxamate as a chelating group. Appl Microbiol Biotechnol 94:1041-1049, 2012. [Abstract]

Protein Studies Research Program
Oklahoma Medical Research Foundation
825 NE 13th Street, MS 28
Oklahoma City, OK 73104

Phone: (405) 271-7291
Fax: (405) 271-7249
Email:  toni-snow@omrf.org