Scientists in our program study free radicals, the highly reactive molecules capable of inducing oxidative damage to DNA, protein, and lipids. The intra- and extracellular content of these species increase during a variety of diseases. Free radical damage is therefore believed to contribute to the accompanying degeneration of physiologic function. Paradoxically, free radicals are also generated in response to normal physiologic stimuli and can exert reversible effects on protein function indicative of metabolic regulation.

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2012

Aurora AB, Mahmoud AI, Luo X, Johnson BA, van Rooij E, Matsuzaki S, Humphries KM, Hill JA, Bassel-Duby R, Sadek HA, Olson EN. MicroRNA-214 protects the mouse heart from ischemic injury by controlling Ca2+ overload and cell death. J Clin Invest 122:1222-1232, 2012. [Abstract]

Griffin TM, Huebner JL, Kraus VB, Yan Z, Guilak F. Induction of osteoarthritis and metabolic inflammation by a very high fat diet in mice: Effects of short-term exercise. Arthritis Rheum 64:443-453, 2012. [Abstract]

Hallgren KW, Zhang D, Kinter M, Willard B, Berkner KL. Methylation of gamma-carboxylated Glu (Gla) allows detection by liquid chromatography-mass spectrometry and the identification of Gla residues in the gamma-glutamyl carboxylase. J Proteome Res 2012. [Abstract] EPub

Ziady AG, Sokolow A, Shank SL, Corey DA, Myers R, Plafker S, Kelley TJ. Interaction with CREB binding protein modulates the activities of Nrf2 AND NF-kappaB in cystic fibrosis airway epithelial cells. Am J Physiol Lung Cell Mol Physiol 2012. [Abstract] EPub

Zhu X, Castellani RJ, Moreira PI, Aliev G, Shenk JC, Siedlak SL, Harris PL, Fujioka H, Sayre LM, Szweda PA, Szweda LI, Smith MA, Perry G. Hydroxynonenal-generated crosslinking fluorophore accumulation in Alzheimer disease reveals a dichotomy of protein turnover. Free Radic Biol Med 52:699-704, 2012. [Abstract]

* Indicates publications by more than one department.

Free Radical Biology & Aging Research Program
Oklahoma Medical Research Foundation
825 NE 13th Street, MS 21
Oklahoma City, OK 73104

Phone: (405) 271-7570
Fax: (405) 271-1437
Email: evansj@omrf.org