What We Do
The Coagulation Biology Laboratory, headed by Charles T. Esmon, Ph.D., investigates the fundamental mechanisms involved in blood coagulation, including complex biological processes such as inflammation, cancer and cardiovascular disease.
A multidisciplinary approach is utilized to address these questions at a molecular level. These approaches encompass all aspects of modern vascular biology including structural biology, structure-function analysis of enzymes and receptors, regulation of the relevant genes, in vivo studies using transgenic and gene deletion approaches, cell biology, protein chemistry, physiological studies, spectral and other biophysical methods for analyzing protein-protein, membrane-protein and cell-cell interactions. This multidisciplinary approach is designed to allow identification of new factors and the mechanisms which regulate the complex processes of coagulation and inflammation and then to be able to translate these findings into an appreciation of their physiological role and their clinical relevance. In addition to their contributions to a fundamental understanding of these systems, the studies have clinical relevance to heart attack, trauma, cancer, stroke, septic shock, hemophilia, organ rejection in transplantation and miscarriages associated with SLE. Several findings made by members of the laboratory have generated patents and licenses leading to development and application of new diagnostics and therapeutics.
Our Publications

2012
Cohen MJ, Call M, Nelson M, Calfee CS, Esmon CT, Brohi K, Pittet JF. Critical role of Activated Protein C in early coagulopathy and later organ failure, infection and death in trauma patients. Ann Surg 255:379-385,2012. [Abstract]
Esmon CT. Protein C anticoagulant system–anti-inflammatory effects. Semin Immunopathol 34:127-132, 2012. [Abstract]
* Izmirly PM, Shvartsbeyn M, Meehan S, Franks A, Braun A, Ginzler E, Xu SX, Yee H, Rivera T, Esmon C, Barisoni L, Merrill JT, Buyon JP, Clancy RM. Dysregulation of the microvasculature in nonlesional non-sun-exposed skin of patients with lupus nephritis. J Rheumatol 2012. [Abstract] EPub
Lopez-Sagaseta J, Puy C, Tamayo I, Allende M, Cervero J, Velasco SE, Esmon CT, Montes R, Hermida J. sPLA2-V inhibits EPCR anticoagulant and antiapoptotic properties by accommodating lysophosphatidylcholine or PAF in the hydrophobic groove. Blood 2012. [Abstract] EPub
Madhusudhan T, Wang H, Straub BK, Grone E, Zhou Q, Shahzad K, Muller-Krebs S, Schwenger V, Gerlitz B, Grinnell BW, Griffin JH, Reiser J, Grone HJ, Esmon CT, Nawroth PP, Isermann B. Cytoprotective signaling by activated protein C requires protease- activated receptor-3 in podocytes. Blood 119:873-882 2012. [Abstract]
* indicates publications by more than one department
Contact Us
Coagulation Biology Laboratory, MS 51
Oklahoma Medical Research Foundation
825 N.E. 13th Street
Oklahoma City, OK 73104
Phone: (405) 271-6474
Fax: (405) 271-2870
E-mail: esmonc@omrf.org

