The Cardiovascular Biology Research Program, headed by Rodger P. McEver, M.D., investigates fundamental mechanisms involved in blood coagulation, inflammation and atherogenesis, with special emphasis on the regulation of these processes.

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2011

Arbuckle JL, Rahman NS, Zhao S, Rodgers W, Rodgers KK. Elucidating the domain architecture and functions of non-core RAG1: the capacity of a non-core zinc-binding domain to function in nuclear import and nucleic acid binding. BMC Biochem 12:23, 2011. [Abstract]

Calloway N, Owens T, Corwith K, Rodgers W, Holowka D, Baird B. Stimulated association of STIM1 and Orai1 is regulated by the balance of PtdIns(4,5)P between distinct membrane pools. J Cell Sci 124:2602-2610, 2011. [Abstract]

Fu J, Wei B, Wen T, Johansson ME, Liu X, Bradford E, Thomsson KA, McGee S, Mansour L, Tong M, McDaniel JM, Sferra TJ, Turner JR, Chen H, Hansson GC, Braun J, Xia L. Loss of intestinal core 1-derived O-glycans causes spontaneous colitis in mice. J Clin Invest 121:1657-1666, 2011. [Abstract]

Griffin CT, Curtis CD, Davis RB, Muthukumar V, Magnuson T. The chromatin-remodeling enzyme BRG1 modulates vascular Wnt signaling at two levels. Proc Natl Acad Sci U S A 108:2282-2287, 2011.  [Abstract]

* He T, Smith N, Saunders D, Doblas S, Watanabe Y, Hoyle J, Silasi-Mansat R, Lupu F, Lerner M, Brackett DJ, Towner RA. Molecular MRI assessment of vascular endothelial growth factor receptor-2 in rat C6 gliomas. J Cell Mol Med 15:837-849, 2011. [Abstract]

* Lupu C, Zhu H, Popescu NI, Wren JD, Lupu F. Novel protein ADTRP regulates TFPI expression and function in human endothelial cells in normal conditions and in response to androgen. Blood 118:4463-4471, 2011. [Abstract]

Marcello MR, Jia W, Leary JA, Moore KL, Evans JP. Lack of tyrosylprotein sulfotransferase-2 activity results in altered sperm-egg interactions and loss of ADAM3 and ADAM6 in epididymal sperm. J Biol Chem 286:13060-13070, 2011. [Abstract]

Miner JJ, Shao B, Wang Y, Chichili GR, Liu Z, Klopocki AG, Yago T, McDaniel JM, Rodgers W, Xia L, McEver RP. Cytoplasmic domain of P-selectin glycoprotein ligand-1 facilitates dimerization and export from the endoplasmic reticulum. J Biol Chem 286:9577-9586, 2011. [Abstract]

Sarangapani KK, Marshall BT, McEver RP, Zhu C. Molecular stiffness of selectins. J Biol Chem 286:9567-9576, 2011. [Abstract]

Sarangapani KK, Qian J, Chen W, Zarnitsyna VI, Mehta P, Yago T, McEver RP, Zhu C. Regulation of catch bonds by rate of force application. J Biol Chem 286:32749-32761, 2011. [Abstract]

Shao B, Wahrenbrock MG, Yao L, David T, Coughlin SR, Xia L, Varki A, McEver RP. Carcinoma mucins trigger reciprocal activation of platelets and neutrophils in a murine model of Trousseau syndrome. Blood 118:4015-4023, 2011. [Abstract]

Wallays G, Nuyens D, Silasi-Mansat R, Souffreau J, Callaerts-Vegh Z, Van Nuffelen A., Moons L, D’hooge R, Lupu F, Carmeliet P, Collen D, Dewerchin M. Notch3 Arg170Cys knock-in mice display pathologic and clinical features of the neurovascular disorder cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy. Arterioscler Thromb Vasc Biol 31:2881-2888, 2011. [Abstract]

*  Webb CF, Bryant J, Popowski M, Allred L, Kim D, Harriss J, Schmidt C, Miner CA, Rose K, Cheng HL, Griffin C, Tucker PW. The ARID family transcription factor Bright is required for both hematopoietic stem cell and B lineage development. Mol Cell Biol 31:1041-1053, 2011.  [Abstract]

Westmuckett AD, Thacker KM, Moore KL. Tyrosine sulfation of native mouse PSGL-1 is required for optimal leukocyte rolling on P-selectin in vivo. PLoS One 6:e20406, 2011. [Abstract]

Yu L, Qin L, Zhang H, He Y, Chen H, Pober JS, Tellides G, Min W. AIP1 prevents graft arteriosclerosis by inhibiting interferon-{gamma}-dependent smooth muscle cell proliferation and intimal expansion. Circ Res 109:418-427, 2011. [Abstract]

Zarbock A, Ley K, McEver RP, Hidalgo A. Leukocyte ligands for endothelial selectins: specialized glycoconjugates that mediate rolling and signaling under flow. Blood 118:6743-6751, 2011. [Abstract]

Zarpellon A, Celikel R, Roberts JR, McClintock RA, Mendolicchio GL, Moore KL, Jing H, Varughese KI, Ruggeri ZM. Binding of {alpha}-thrombin to surface-anchored platelet glycoprotein Ib{alpha} sulfotyrosines through a two-site mechanism involving exosite I. Proc Natl Acad Sci U S A 108:8628-8633, 2011. [Abstract]

Zhang X, Yu H, Lou JR, Zheng J, Zhu H, Popescu NI, Lupu F, Lind SE, Ding WQ.  microRNA-19 (miR-19) regulates tissue factor expression in breast cancer cells. J Biol Chem 286:1429-1435, 2011. [Abstract]

Zsuzsa S, Kiss A, Erdodi F, Setiadi H, Debreceni IB, Nagy B, Kappelmayer J. Protein phosphatase inhibitor calyculin – A modulates activation markers in TRAP-stimulated human platelets. Platelets 21:555-562, 2011.

2012

Curtis CD, Griffin CT. The chromatin-remodeling enzymes BRG1 and CHD4 antagonistically regulate vascular Wnt signaling. Mol Cell Biol 2012. [Abstract] EPub

Jones D, Li Y, He Y, Xu Z, Chen H, Min W. Mirtron microRNA-1236 inhibits VEGFR-3 signaling during inflammatory lymphangiogenesis. Arterioscler Thromb Vasc Biol 2012. [Abstract] EPub

Kanan Y, Hamilton RA, Moore KL, Al-Ubaidi MR. Protein tyrosine-o-sulfation in bovine ocular tissues. Adv Exp Med Biol 723:835-841, 2012. [Abstract]

Kim PY, Kim PY, Taylor FB, Jr., Nesheim ME. Thrombin-activatable fibrinolysis inhibitor is activated in vivo in a baboon model of Escherichia coli induced sepsis. J Thromb Thrombolysis 2012. [Abstract] EPub

Taylor FB, Jr., Kinasewitz GT, Lupu F. Pathophysiology, staging and therapy of severe sepsis in baboon models. J Cell Mol Med 2012. [Abstract] EPub

Zhai Z, Gomez-Mejiba SE, Zhu H, Lupu F, Ramirez DC. The spin trap 5,5-dimethyl-1-pyrroline N-oxide inhibits lipopolysaccharide-induced inflammatory response in RAW 264.7 cells. Life Sci 2012. [Abstract] EPub

* Indicates publications by more than one department.

Cardiovascular Biology Research Program
Oklahoma Medical Research Foundation
825 NE 13th Street, MS 45
Oklahoma City, OK 73104

Phone: (405) 271-6480
Fax: (405) 271-3137
Email:  Anita-James@OMRF.org