What We Do

The Cardiovascular Biology Research Program, headed by Rodger P. McEver, M.D., investigates fundamental mechanisms involved in blood coagulation, inflammation and atherogenesis, with special emphasis on the regulation of these processes.
This program utilizes a multidisciplinary approach to address these questions at a molecular level. This approach encompasses all aspects of modern vascular biology, including structural biology, structure-function analysis of enzymes and receptors, regulation of the relevant genes, in vivo studies using transgenic and gene deletion approaches, cell biology, protein chemistry, physiological studies and spectral and other biophysical methods for analyzing protein-protein, membrane-protein and cell-cell interactions.
The multidisciplinary approach allows identification of new factors and the mechanisms that regulate coagulation and inflammation and enables translation of these findings into an appreciation of their physiological role and clinical relevance. In addition to contributing to a fundamental understanding of these systems, the studies have clinical relevance to heart attack, stroke, septic shock, hemophilia, acute organ rejection in transplantation and miscarriages associated with SLE. Several findings by department members have generated patents and licenses that have led to new diagnostics and therapeutics.
Our Publications

2012
Curtis CD, Griffin CT. The chromatin-remodeling enzymes BRG1 and CHD4 antagonistically regulate vascular Wnt signaling. Mol Cell Biol 32:1312-1320, 2012. [Abstract]
Jones D, Li Y, He Y, Xu Z, Chen H, Min W. Mirtron microRNA-1236 inhibits VEGFR-3 signaling during inflammatory lymphangiogenesis. Arterioscler Thromb Vasc Biol 32:633-642, 2012. [Abstract]
Kanan Y, Hamilton RA, Moore KL, Al-Ubaidi MR. Protein tyrosine-o-sulfation in bovine ocular tissues. Adv Exp Med Biol 723:835-841, 2012. [Abstract]
Kim PY, Kim PY, Taylor FB, Jr., Nesheim ME. Thrombin-activatable fibrinolysis inhibitor is activated in vivo in a baboon model of Escherichia coli induced sepsis. J Thromb Thrombolysis 33:412-415, 2012. [Abstract]
Shao B, Yago T, Coghill PA, Klopocki AG, Mehta-D’Souza P, Schmidtke DW, Rodgers W, McEver RP. Signal-dependent slow leukocyte rolling does not require cytoskeletal anchorage of P-selectin glycoprotein ligand-1 (PSGL-1) or integrin alphaLbeta2. J Biol Chem 2012. [Abstract] EPub
Taylor FB, Jr., Kinasewitz GT, Lupu F. Pathophysiology, staging and therapy of severe sepsis in baboon models. J Cell Mol Med 16:672-682, 2012. [Abstract]
Zhai Z, Gomez-Mejiba SE, Zhu H, Lupu F, Ramirez DC. The spin trap 5,5-dimethyl-1-pyrroline N-oxide inhibits lipopolysaccharide-induced inflammatory response in RAW 264.7 cells. Life Sci 90:432-439, 2012. [Abstract]
* Indicates publications by more than one department.
Contact Us

Cardiovascular Biology Research Program
Oklahoma Medical Research Foundation
825 NE 13th Street, MS 45
Oklahoma City, OK 73104
Phone: (405) 271-6480
Fax: (405) 271-3137
Email: Anita-James@OMRF.org




