Scientists in the Arthritis & Clinical Immunology Research Program focus on understanding the etiology, pathogenesis and molecular mechanisms of systemic autoimmunity, as well as understanding immunologic responses to infection and vaccination. Using genetic, genomic, proteomic, immunologic and molecular approaches, our investigators are working to understand complex human diseases such as systemic lupus erythematosus, Sjogren’s syndrome, rheumatoid arthritis, inflammatory myositis, multiple sclerosis and thrombotic thrombocytopenic purpura, as well as to decipher mechanisms of immune protection after influenza or anthrax vaccination. To facilitate these patient-oriented research activities, some of our scientists are also working to develop novel methods and algorithms to mine large datasets and evaluate complex human genetic diseases.

2012

Adrianto I, Montgomery C. Estimating allele frequencies. Methods Mol Biol 850:59-76, 2012. [Abstract]

Anaya JM, Kim-Howard X, Prahalad S, Chernavsky A, Canas C, Rojas-Villarraga A, Bohnsack J, Jonsson R, Bolstad AI, Brun JG, Cobb B, Moser KL, James JA, Harley JB, Nath SK. Evaluation of genetic association between an ITGAM non-synonymous SNP (rs1143679) and multiple autoimmune diseases. Autoimmun Rev 11:276-280, 2012.[Abstract]

* Castillejo-López C, Delgado-Vega AM, Wojcik J, Kozyrev SV, Thavathiru E, Wu YY, Sanchez E, Pöllmann D, Lopez-Egido JR, Fineschi S, Dominguez N, Lu R, James JA, Merrill JT, Kelly JA, Kaufman KM, Moser KL, Gilkeson G, Frostegård J, Pons-Estel BA, D’Alfonso S, Witte T, Callejas JL, Harley JB, Gaffney PM, Martin J, Guthridge JM, Alarcón-Riquelme ME. Genetic and physical interaction of the B-cell systemic lupus erythematosus-associated genes BANK1 and BLK. Ann Rheum Dis 71:136-142,2012. [Abstract]

Chakravarty E. Pre-disease pregnancy complications and systemic sclerosis: pathogenic or pre-clinical? Arthritis Res Ther 14:102, 2012. [Abstract] EPub

Chakravarty EF, Hubert HB, Krishnan E, Bruce BB, Lingala VB, Fries JF. Lifestyle risk factors predict disability and death in healthy aging adults. Am J Med 125:190-197, 2012. [Abstract]

Clemmensen SN, Bohr CT, Rorvig S, Glenthoj A, Mora-Jensen H, Cramer EP, Jacobsen LC, Larsen MT, Cowland JB, Tanassi JT, Heegaard NH, Wren JD, Silahtaroglu AN, Borregaard N. Olfactomedin 4 defines a subset of human neutrophils. J Leukoc Biol 91:495-500, 2012.  [Abstract]

Clowse ME, Chakravarty E, Costenbader KH, Chambers C, Michaud K. The effects of infertility, pregnancy loss, and patient concerns on family size of women with rheumatoid arthritis and systemic lupus erythematosus. Arthritis Care Res (Hoboken) 64:668-674, 2012. [Abstract]

Cuda CM, Li S, Liang S, Yin Y, Potula HH, Xu Z, Sengupta M, Chen Y, Butfiloski E, Baker H, Chang LJ, Dozmorov I, Sobel ES, Morel L. Pre-B Cell Leukemia Homeobox 1 Is Associated with Lupus Susceptibility in Mice and Humans. J Immunol  188:604-614,2012. [Abstract]

Dillon SP, Kurien BT, Li S, Bruner GR, Kaufman KM, Harley JB, Gaffney PM, Wallace DJ, Weisman MH, Scofield RH. Sex chromosome aneuploidies among men with systemic lupus erythematosus. J Autoimmun 38:J129-J134,2012. [Abstract]

Dozmorov MG, Cara LR, Giles CB, Wren JD. GenomeRunner: Automating genome exploration. Bioinformatics 28:419-420, 2012. [Abstract]

Gaddy JR, Khan ZZ, Chaser B, Scofield RH. Whipple’s disease diagnosis following the use of TNF-alpha blockade. Rheumatology (Oxford)51:946, 2012. [Abstract]

Guthridge JM, Clark DN, Templeton A, Dominguez N, Lu R, Vidal GS, Kelly JA, Kauffman KM, Harley JB, Gaffney PM, James JA, Poole BD. Effects of IRF5 lupus risk haplotype on pathways predicted to influence B cell functions. J Biomed Biotechnol 2012:594056, 2012. [Abstract]

Horton CG, Farris AD. Toll-like Receptors in Systemic Lupus Erythematosus: Potential Targets for Therapeutic Intervention. Curr Allergy Asthma Rep 12:1-7,2012. [Abstract]

* Hughes T, Adler A, Kelly JA, Kaufman KM, Williams A, Langefeld CD, Brown EE, Alarcon GS, Kimberly RP, Edberg JC, Ramsey-Goldman R, Petri M, Boackle SA, Stevens AM, Reveille JD, Sanchez E, Martin J, Niewold TB, Vila LM, Scofield RH, Gilkeson GS, Gaffney PM, Criswell LA, Moser KL, Merrill JT, Jacob CO, Tsao BP, James JA, Vyse TJ, Alarcon-Riquelme ME, on behalf of the BIOLUPUS network, Harley JB, Richardson BC, Sawalha AH. Evidence for gene-gene epistatic interactions among susceptibility loci for systemic lupus erythematosus. Arthritis Rheum 64:485-492, 2012. [Abstract]

* Hughes T, Adler A, Merrill JT, Kelly JA, Kaufman KM, Williams A, Langefeld CD, Gilkeson GS, Sanchez E, Martin J, Boackle SA, Stevens AM, Alarcon GS, Niewold TB, Brown EE, Kimberly RP, Edberg JC, Ramsey-Goldman R, Petri M, Reveille JD, Criswell LA, Vila LM, Jacob CO, Gaffney PM, Moser KL, Vyse TJ, Alarcon-Riquelme ME, BIOLUPUS N, James JA, Tsao BP, Scofield RH, Harley JB, Richardson BC, Sawalha AH. Analysis of autosomal genes reveals gene-sex interactions and higher total genetic risk in men with systemic lupus erythematosus. Ann Rheum Dis 71:694-699, 2012. [Abstract]

Ice JA, Li H, Adrianto I, Lin PC, Kelly JA, Montgomery CG, Lessard CJ, Moser KL. Genetics of Sjogren’s syndrome in the genome-wide association era. J Autoimmun 2012. [Abstract] EPub

* Ichii M, Frank MB, Iozzo RV, Kincade PW. The canonical Wnt pathway shapes niches supportive for hematopoietic stem/progenitor cells. Blood 119:1683-1692, 2012.  [Abstract]

Jacob CO, Eisenstein M, Dinauer MC, Ming W, Liu Q, John S, Quismorio FP, Jr., Reiff A, Myones BL, Kaufman KM, McCurdy D, Harley JB, Silverman E, Kimberly RP, Vyse TJ, Gaffney PM, Moser KL, Klein-Gitelman M, Wagner-Weiner L, Langefeld CD, Armstrong DL, Zidovetzki R. Lupus-associated causal mutation in neutrophil cytosolic factor 2 (NCF2) brings unique insights to the structure and function of NADPH oxidase. Proc Natl Acad Sci U S A 109:E59-E67,2012. [Abstract]

James JA, Robertson JM. Lupus and Epstein-Barr. Curr Opin Rheumatol 2012. [Abstract] EPub

Joshi SK, Lang GA, Devera TS, Johnson AM, Kovats S, Lang ML. Differential contribution of dendritic cell CD1d to NKT cell-enhanced humoral immunity and CD8+ T cell activation. J Leukoc Biol 2012. [Abstract] EPub

* Kim K, Brown EE, Choi CB, Alarcon-Riquelme ME, on behalf of BIOLUPUS, Kelly JA, Glenn SB, Ojwang JO, Adler A, Lee HS, Boackle SA, Criswell LA, Alarcon GS, Edberg JC, Stevens AM, Jacob CO, Gilkeson GS, Kamen DL, Tsao BP, Anaya JM, Guthridge JM, Nath SK, Richardson B, Sawalha AH, Kang YM, Shim SC, Suh CH, Lee SK, Kim CS, Merrill JT, Petri M, Ramsey-Goldman R, Vila LM, Niewold TB, Martin J, Pons-Estel BA, on behalf of GENLES, Vyse TJ, Freedman BI, Moser KL, Gaffney PM, Williams A, Comeau M, Reveille JD, James JA, Scofield RH, Langefeld CD, Kaufman KM, Harley JB, Kang C, Kimberly RP, Bae SC. Variation in the ICAM1-ICAM4-ICAM5 locus is associated with systemic lupus erythematosus susceptibility in multiple ancestries. Ann Rheum Dis 2012. [Abstract]EPub

* Knowlton N, Wages J, Centola M, Alaupovic P. Apolipoprotein-defined lipoprotein abnormalities in rheumatoid arthritis patients and their potential impact on cardiovascular disease. Scand J Rheumatol 2012. [Abstract] EPub

* Knowlton N, Wages J, Centola M, Giles J, Bathon J, Quiroga C, Alaupovic P. Apolipoprotein B-containing lipoprotein subclasses as risk factors for cardiovascular disease in patients with rheumatoid arthritis. Arthritis Care Res (Hoboken) 2012. [Abstract] EPub

Korte EA, Gaffney PM, Powell DW. Contributions of mass spectrometry-based proteomics to defining cellular mechanisms and diagnostic markers for systemic lupus erythematosus. Arthritis Res Ther 14:204, 2012. [Abstract]

Kozyrev SV, Bernal-Quiros M, Alarcón-Riquelme ME, Castillejo-Lopez C. The dual effect of the lupus-associated polymorphism rs10516487 on BANK1 gene expression and protein localization. Genes Immun 12:129-138, 2012.[Abstract]

Kurien BT, D’Souza A, Terzyan S, Scofield RH. Putative sequences on Ro60 three-dimensional structure accessible for 4-hydroxy-2-nonenal (HNE) modification compared to in vitro HNE modification of Ro60 sequences. Mol Immunol 50:185-192,2012. [Abstract]

* Lessard CJ, Adrianto I, Ice JA, Wiley GB, Kelly JA, Glenn SB, Adler AJ, Li H, Rasmussen A, Williams AH, Ziegler J, Comeau ME, Marion M, Wakeland BE, Liang C, Ramos PS, Grundahl KM, Gallant CJ, Marta E.Alarcon-Riquelme for the BIOLUPUS and GENLES Networks, Alarcon GS, Anaya JM, Bae SC, Boackle SA, Brown EE, Chang DM, Cho SK, Criswell LA, Edberg JC, Freedman BI, Gilkeson GS, Jacob CO, James JA, Kamen DL, Kimberly RP, Kim JH, Martin J, Merrill JT, Niewold TB, Park SY, Petri MA, Pons-Estel BA, Ramsey-Goldman R, Reveille JD, Scofield RH, Song YW, Stevens AM, Tsao BP, Vila LM, Vyse TJ, Yu CY, Guthridge JM, Kaufman KM, Harley JB, Wakeland EK, Langefeld CD, Gaffney PM, Montgomery CG, Moser KL. Identification of IRF8, TMEM39A, and IKZF3-ZPBP2 as Susceptibility Loci for Systemic Lupus Erythematosus in a Large-Scale Multiracial Replication Study. Am J Hum Genet 90:648-660, 2012. [Abstract]

Lessard CJ, Ice JA, Adrianto I, Wiley G, Kelly JA, Gaffney PM, Montgomery CG, Moser KL. The genomics of autoimmune disease in the era of genome-wide association studies and beyond. Autoimmun Rev 11:267-275, 2012.[Abstract]

* Lin CP, Adrianto I, Lessard CJ, Kelly JA, Kaufman KM, Guthridge JM, Freedman BI, Anaya JM, Alarcon-Riquelme ME, on behalf of the BIOLUPUS and GENLES Networks, Pons-Estel BA, Martin J, Glenn S, Adler A, Bae SC, Park SY, Bang SY, Song YW, Boackle SA, Brown EE, Edberg JC, Alarcon GS, Petri MA, Criswell LA, Ramsey-Goldman R, Reveille JD, Vila LM, Gilkeson GS, Kamen DL, Ziegler J, Jacob CO, Rasmussen A, James JA, Kimberly RP, Merrill JT, Niewold TB, Scofield RH, Stevens AM, Tsao BP, Vyse TJ, Langefeld CD, Moser KL, Harley JB, Gaffney PM, Montgomery CG. Role of MYH9 and APOL1 in African and non-African populations with lupus nephritis. Genes Immun 13:232-238, 2012. [Abstract]

Löfgren SE, Frostegård J, Truedsson L, Pons-Estel BA, D’Alfonso S, Witte T, Lauwerys BR, Endreffy E, Kovács L, Vasconcelos C, Martins da Silva B, Kozyrev SV, Alarcón-Riquelme ME. Genetic association of miRNA-146a with systemic lupus erythematosus in Europeans through decreased expression of the gene. Genes Immun 13:268-274,2012. [Abstract]

Maiti AK. Genetic determinants of oxidative stress-mediated sensitization of drug resistant cancer cells. Int J Cancer 130:1-9, 2012.[Abstract]

Namjou B, Choi CB, Harley IT, Alarcon-Riquelme ME, on behalf of BIOLUPUS, Kelly JA, Glenn SB, Ojwang JO, Adler A, Kim K, Gallant CJ, Boackle SA, Criswell LA, Kimberly RP, Brown EE, Edberg J, Alarcon GS, Stevens AM, Jacob CO, Gilkeson GS, Kamen DL, Tsao BP, Anaya JM, Kim EM, Park SY, Sung YK, Guthridge JM, Merrill JT, Petri M, Ramsey-Goldman R, Vila LM, Niewold TB, Martin J, Pons-Estel BA, on behalf of GENLES, Vyse TJ, Freedman BI, Moser KL, Gaffney PM, Williams AH, Comeau ME, Reveille JD, Kang C, James JA, Scofield RH, Langefeld CD, Kaufman KM, Harley JB, Bae SC. Evaluation of TRAF6 in a large multi-ancestral lupus cohort. Arthritis Rheum 2012. [Abstract] EPub

Namjou B, Keddache M, Fletcher D, Dillon S, Kottyan L, Wiley G, Gaffney P, Wakeland B, Liang C, Wakeland E, Scofield R, Kaufman K, Harley J. Identification of novel coding mutation in C1qA gene in an African-American pedigree with lupus and C1q deficiency. Lupus 2012. [Abstract] EPub

* Niewold TB, Kelly JA, Kariuki SN, Franek BS, Kumar AA, Kaufman KM, Thomas K, Walker D, Kamp S, Frost JM, Wong AK, Merrill JT, Alarcon-Riquelme ME, Tikly M, Ramsey-Goldman R, Reveille JD, Petri MA, Edberg JC, Kimberly RP, Alarcon GS, Kamen DL, Gilkeson GS, Vyse TJ, James JA, Gaffney PM, Moser KL, Crow MK, Harley JB. IRF5 haplotypes demonstrate diverse serological associations which predict serum interferon alpha activity and explain the majority of the genetic association with systemic lupus erythematosus. Ann Rheum Dis 71:463-469, 2012. [Abstract]

Peng H, Bateman A, Valencia A, Wren JD. Bioimage Informatics: A New Category in Bioinformatics. Bioinformatics 28:1057, 2012. [Abstract]

Radhakrishna U, Nath SK, McElreavey K, Ratnamala U, Sun C, Maiti AK, Gagnebin M, Bena F, Newkirk HL, Sharp AJ, Everman DB, Murray JC, Schwartz CE, Antonarakis SE, Butler MG. Genome-wide linkage and copy number variation analysis reveals 710 kb duplication on chromosome 1p31.3 responsible for autosomal dominant omphalocele. J Med Genet 49:270-276, 2012. [Abstract]

Radhakrishna U, Ratnamala U, Deutsch S, Bartoloni L, Kuracha MR, Singh R, Banwait J, Bastola DK, Johar K, Nath SK, Antonarakis SE. Novel homozygous, heterozygous and hemizygous FRMD7 gene mutations segregated in the same consanguineous family with congenital X-linked nystagmus. Eur J Hum Genet 2012. [Abstract] EPub

* Sawalha AH, Wang L, Nadig A, Somers EC, McCune WJ, the Michigan Lupus Consortium, Hughes T, Merrill JT, Scofield RH, Strickland FM, Richardson B. Sex-specific differences in the relationship between genetic susceptibility, T cell DNA demethylation and lupus flare severity. J Autoimmun 38:J216-J222,2012. [Abstract]

Segal BM, Pogatchnik B, Holker E, Liu H, Sloan J, Rhodus N, Moser KL. Primary Sjogren’s syndrome: cognitive symptoms, mood, and cognitive performance. Acta Neurol Scand 125:272-278, 2012. [Abstract]

Smith K, Crowe SR, Garman L, Guthridge C, Muther JJ, McKee E, Farris AD, Guthridge JM, Wilson PC, James JA. Human monoclonal antibodies generated following vaccination with AVA provide neutralization by blocking furin cleavage but not by preventing oligomerization. Vaccine 2012. [Abstract] EPub

Strickland FM, Hewagama A, Lu Q, Wu A, Hinderer R, Webb R, Johnson K, Sawalha AH, Delaney C, Yung R, Richardson BC. Environmental exposure, estrogen and two X chromosomes are required for disease development in an epigenetic model of lupus. J Autoimmun 38:J135-J143,2012. [Abstract]

Teruel M, Martin JE, Ortego-Centeno N, Jiménez-Alonso J, Sánchez-Román J, de Ramón E., Gonzalez-Escribano MF, Pons-Estel BA, D’Alfonso S, Sebastiani GD, Witte T, Bottini N, González-Gay MA, Alarcón-Riquelme ME, Martin J. Novel association of acid phosphatase locus 1*C allele with systemic lupus erythematosus. Hum Immunol 73:107-110, 2012. [Abstract]

* Vista E, Crowe S, Thompson L, Air G, Robertson J, Guthridge J, James J. Influenza vaccination can induce new-onset anticardiolipins but not beta2-glycoprotein-I antibodies among patients with systemic lupus erythematosus. Lupus 21:168-174, 2012. [Abstract]

*Wang S, Adrianto I, Wiley GB, Lessard CJ, Kelly JA, Adler AJ, Glenn SB, Williams AH, Ziegler JT, Comeau ME, Marion MC, Wakeland BE, Liang C, Kaufman KM, Guthridge JM, Alarcón-Riquelme ME, on behalf of the BIOLUPUS and GENLES Networks, Alarcon GS, Anaya JM, Bae SC, Kim JH, Joo YB, Boackle SA, Brown EE, Petri MA, Ramsey-Goldman R, Reveille JD, Vila LM, Criswell LA, Edberg JC, Freedman BI, Gilkeson GS, Jacob CO, James JA, Kamen DL, Kimberly RP, Martin J, Merrill JT, Niewold TB, Pons-Estel BA, Scofield RH, Stevens AM, Tsao BP, Vyse TJ, Langefeld CD, Harley JB, Wakeland EK, Moser KL, Montgomery CG, Gaffney PM. A functional haplotype of UBE2L3 confers risk for systemic lupus erythematosus. Genes Immun 2012. [Abstract] EPub

Weckerle CE, Imbuka D, Franek BS, Kelly JA, Kumabe M, James JA, Moser KL, Harley JB, Niewold TB. Large scale analysis of tumor necrosis factor alpha levels in systemic lupus erythematosus. Arthritis Rheum 2012. [Abstract] EPub

Yan X, Li F, Dozmorov I, Frank MB, Dao M, Centola M, Cao W, Hu D. External Qi of Yan Xin Qigong induces cell death and gene expression alterations promoting apoptosis and inhibiting proliferation, migration and glucose metabolism in small-cell lung cancer cells. Mol Cell Biochem 363:245-255, 2012. [Abstract]

Zhou XJ, Lu XL, Nath SK, Lv JC, Zhu SN, Yang HZ, Qin LX, Zhao MH, Su Y, The International Consortium for Systemic Lupus Erythematosus Genetics (SLEGEN), Shen N, Li ZG, Zhang H. Gene-gene interaction of BLK, TNFSF4, TRAF1, TNFAIP3, REL in systemic lupus erythematosus. Arthritis Rheum 64:222-231,2012. [Abstract]

* Indicates publications by more than one department.

Arthritis & Clinical Immunology Research Program
Oklahoma Medical Research Foundation
825 NE 13th Street, MS 53
Oklahoma City, OK 73104

Phone: (405) 271-4987
Fax: (405) 271- 7063
Email:  jamesj@omrf.org