Molecular Mechanisms and Genetics of Autoimmunity

The Oklahoma Medical Research Foundation (OMRF) with the support of the National Institute of General Medical Sciences (NIGMS) has founded a Center of Biomedical Research Excellence (COBRE) with the scientific theme of molecular mechanisms and genetics of autoimmunity. OMRF has historically been a focal point of outstanding science in the field of immunology, with OMRF faculty responsible for a number of seminal discoveries. To continue this tradition of scientific excellence, the overall goal of this COBRE is to foster and develop the promising talent of our Junior Investigators into independent researchers while producing sound scientific contributions.
This Center has supported 24 Junior Investigators over the last five years, through either pilot funding or full investigator support. These Junior Investigators are supported by exceptional Mentors who will provide the guidance and advocacy critical for launching the successful careers of independent scientists. The Center projects are also facilitated by four scientific Cores, including a Nucleic Acid Analysis Core, a Data Analysis Core, a Biorepository Core, and a Bioinformatics Core, all of which are directed by highly experienced and knowledgeable staff scientists. These Cores efficiently and economically apply the most sophisticated technologies and methods to the problems being addressed by the Junior Investigators. Additional COBRE Junior Investigators will continue to be recruited to this Center, making this a transitional mechanism for the development of many independent investigators and thereby sustaining the level of excellence now achieved in the research of autoimmunity in Oklahoma. The synergies, collaborations, and directed effort of the COBRE will provide a much deeper level of understanding to human autoimmune diseases and will foster the independent career development of a strong group of Junior Investigators.