2014 Scientific Publications

Advanced Magnetic Resonance Center

Gomez-Mejiba SE, Zhai Z, Della-Vedova MC, Munoz MD, Chatterjee S, Towner RA, Hensley K, Floyd RA, Mason RP, Ramirez DC. Immuno-spin trapping from biochemistry to medicine: Advances, challenges, and pitfalls. Focus on protein-centered radicals. Biochim Biophys Acta 1840:722-729, 2014. [Abstract]

Arthritis and  Clinical Immunology Research Program

Altorok N, Coit P, Hughes T, Koelsch KA, Stone DU, Rasmussen A, Radfar L, Scofield RH, Sivils KL, Farris AD, Sawalha AH. Genome-wide DNA methylation patterns in naive CD4 T cells from patients with primary Sjogren’s syndrome. Arthritis Rheum 66:731-739, 2014. [Abstract]

Armstrong DL, Zidovetzki R, Alarcón-Riquelme ME, Tsao BP, Criswell LA, Kimberly RP, Harley JB, Sivils KL, Vyse TJ, Gaffney PM, Langefeld CD, Jacob CO. GWAS identifies novel SLE susceptibility genes and explains the association of the HLA region. Genes Immun 2014. [Abstract] EPub

Bagavant H, Nandula SR, Kaplonek P, Rybakowska PD, Deshmukh US. Alum, an aluminum-based adjuvant, induces Sjogren’s syndrome-like disorder in mice. Clin Exp Rheumatol 32:251-255, 2014. [Abstract]

Brown KM, Suvorova E, Farrell A, McLain A, Dittmar A, Wiley GB, Marth G, Gaffney PM, Gubbels MJ, White M, Blader IJ. Forward  Forward genetic screening identifies a small molecule that blocks Toxoplasma gondii growth by inhibiting both host- and parasite-encoded kinases. PLoS Pathog 10:e1004180, 2014. [Abstract]

Carreras E, Kovats S.     Girl power: estrogen promotes HSC self-renewal. Cell Stem Cell 14:137-138, 2014. [Abstract]

Cekanaviciute E, Dietrich HK, Axtell RC, Williams AM, Egusquiza R, Wai KM, Koshy AA, Buckwalter MS. Astrocytic TGF-beta signaling limits inflammation and reduces neuronal damage during central nervous system toxoplasma infection. J Immunol 193:139-149, 2014. [Abstract]

Chakravarty E, Clowse ME, Pushparajah DS, Mertens S, Gordon C. Family planning and pregnancy issues for women with systemic inflammatory diseases: patient and physician perspectives. BMJ Open 4:e004081, 2014. [Abstract]

Chung SA, Brown EE, Williams AH, Ramos PS, Berthier CC, Bhangale T, Alarcón-Riquelme ME, Behrens TW, Criswell LA, Graham DC, Demirci FY, Edberg JC, Gaffney PM, Harley JB, Jacob CO, Kamboh MI, Kelly JA, Manzi S, Moser-Sivils KL, Russell LP, Petri M, Tsao BP, Vyse TJ, Zidovetzki R, Kreztler M, Kimberly RP, Freedman BI, Graham RR, Langefeld CD, for the International Consortium for Systemic Lupus Erythematosus Genetics. Lupus nephritis susceptibility loci in women with systemic lupus erythematosus. J Am Soc Nephrol 2014. [Abstract] EPub

Dozmorov MG, Wren JD, Alarcón-Riquelme ME. Epigenomic elements enriched in the promoters of autoimmunity susceptibility genes. Epigenetics 9:276-285, 2014. [Abstract]

Ferucci ED, Choromanski TL, Hurlburt KJ, Livingston S, Plotnik J, Manns MP, McMahon BJ, James JA. Autoimmune hepatitis in the Alaska Native population: autoantibody profile and HLA associations. Liver Int 2013. [Abstract] EPub

Filippi M, Rocca MA, Pagani E, De SN, Jeffery D, Kappos L, Montalban X, Boyko AN, Comi G, on behalf of the ALLEGRO Study Group. Placebo-controlled trial of oral laquinimod in multiple sclerosis: MRI evidence of an effect on brain tissue damage. J Neurol Neurosurg Psychiatry 2014. [Abstract] EPub

* Freedman BI, Langefeld CD, Andringa KK, Croker JA, Williams AH, Garner NE, Birmingham DJ, Hebert LA, Hicks PJ, Segal MS, Edberg JC, Brown EE, Alarcon GS, Costenbader KH, Comeau ME, Criswell LA, Harley JB, James JA, Kamen DL, Lim SS, Merrill JT, Sivils KL, Niewold TB, Patel NM, Petri M, Ramsey-Goldman R, Reveille JD, Salmon JE, Tsao BP, Gibson KL, Byers JR, Vinnikova AK, Lea JP, Julian BA, Kimberly RP, Lupus  end-stage renal disease in African Americans with lupus nephritis is associated with APOL1. Arthritis Rheumatol 66:390-396, 2014. [Abstract]

Guda K, Fink SP, Milne G, Molyneaux N, Ravi L, Lewis SM, Dannenberg AJ, Montgomery CG, Zhang S, Willis JE, Wiesner GL, Markowitz SD. Inactivating mutation in the prostaglandin transporter gene, SLCO2A1, associated with familial digital clubbing, colon neoplasia, and NSAID resistance. Cancer Prev Res (Phila) 2014. [Abstract]

* Guthridge JM, Lu R, Sun H, Sun C, Wiley GB, Dominguez N, Macwana SR, Lessard CJ, Kim-Howard X, Cobb BL, Kaufman KM, Kelly JA, Langefeld CD, Adler AJ, Harley IT, Merrill JT, Gilkeson GS, Kamen DL, Niewold TB, Brown EE, Edberg JC, Petri MA, Ramsey-Goldman R, Reveille JD, Vila LM, Kimberly RP, Freedman BI, Stevens AM, Boackle SA, Criswell LA, Vyse TJ, Behrens TW, Jacob CO, Alarcon-Riquelme ME, Sivils KL, Choi J, Joo YB, Bang SY, Lee HS, Bae SC, Shen N, Qian X, Tsao BP, Scofield RH, Harley JB, Webb CF, Wakeland EK, James JA, Nath SK, Graham RR, Gaffney PM. Two functional lupus-associated BLK promoter variants control cell-type- and developmental-stage-specific transcription. Am J Hum Genet 94:586-598, 2014. [Abstract]

Huber AM, Mamyrova G, Lachenbruch PA, Lee JA, Katz JD, Targoff IN, Miller FW, Rider LG, for the Childhood Myositis Heterogeneity Study Group. Early illness features associated with mortality in the juvenile idiopathic inflammatory myopathies. Arthritis Care Res (Hoboken) 66:732-740, 2014. [Abstract]

Husain F, Levin J, Scott J, Fjeldstad C. Recurrent refrains in a patient with multiple sclerosis: earworms or musical hallucinations? Mult Scler Relat Disord 2014. EPub

Jeffries MA, Donica M, Baker L, Stevenson M, Annan AC, Humphrey MB, James JA, Sawalha AH. Genome-wide DNA methylation study identifies significant epigenomic changes in osteoarthritic cartilage. Arthritis Rheumatol 2014. [Abstract] EPub

Kaufman M, Pardo G, Rossman H, Sweetser MT, Forrestal F, Duda P. Natalizumab treatment shows no clinically meaningful effects on immunization responses in patients with relapsing-remitting multiple sclerosis. J Neurol Sci 341:22-27, 2014. [Abstract]

Kim K, Bang SY, Lee HS, Cho SK, Choi CB, Sung YK, Kim TH, Jun JB, Yoo DH, Kang YM, Kim SK, Suh CH, Shim SC, Lee SS, Lee J, Chung WT, Choe JY, Shin HD, Lee JY, Han BG, Nath SK, Eyre S, Bowes J, Pappas DA, Kremer JM, Gonzalez-Gay MA, Rodriguez-Rodriguez L, Arlestig L, Okada Y, Diogo D, Liao KP, Karlson EW, Raychaudhuri S, Rantapaa-Dahlqvist S, Martin J, Klareskog L, Padyukov L, Gregersen PK, Worthington J, Greenberg JD, Plenge RM, Bae SC. High-density genotyping of immune loci in Koreans and Europeans identifies eight new rheumatoid arthritis risk loci. Ann Rheum Dis 2014. [Abstract] EPub

Kim-Howard X, Sun C, Molineros JE, Maiti AK, Chandru H, Adler A, Wiley GB, Kaufman KM, Kottyan L, Guthridge JM, Rasmussen A, Kelly J, Sanchez E, Raj P, Li QZ, Bang SY, Lee HS, Kim TH, Kang YM, Suh CH, Chung WT, Park YB, Choe JY, Shim SC, Lee SS, Han BG, Olsen NJ, Karp DR, Moser K, Pons-Estel BA, Wakeland EK, James JA, Harley JB, Bae SC, Gaffney PM, Alarcón-Riquelme M, on behalf of GENLES, Looger LL, Nath SK. Allelic heterogeneity in NCF2 associated with systemic lupus erythematosus (SLE) susceptibility across four ethnic populations. Hum Mol Genet 23:1656-1668, 2014. [Abstract]

Langen ES, Chakravarty EF, Liaquat M, El-Sayed YY, Druzin ML. High rate of preterm birth in pregnancies complicated by rheumatoid arthritis. Am J Perinatol Am J Perinatol 31:9-14, 2014. [Abstract]

Levin AM, Adrianto I, Datta I, Iannuzzi MC, Trudeau S, McKeigue P, Montgomery CG, Rybicki BA. Performance of HLA allele prediction methods in African Americans for class II genes HLA-DRB1, -DQB1, and -DPB1. BMC Genet 15:72, 2014. [Abstract]

Levin AM, Iannuzzi MC, Montgomery CG, Trudeau S, Datta I, Adrianto I, Chitale DA, McKeigue P, Rybicki BA. Admixture fine-mapping in African Americans implicates XAF1 as a possible sarcoidosis risk gene. PLoS One 9:e92646, 2014. [Abstract]

Li J, Yang J, Levin AM, Montgomery CG, Datta I, Trudeau S, Adrianto I, McKeigue P, Iannuzzi MC, Rybicki BA. Efficient  generalized least squares method for mixed population and family-based samples in genome-wide association studies. Genet Epidemiol 38:430-438, 2014. [Abstract]

* Maier-Moore JS, Horton CG, Mathews SA, Confer AW, Lawrence C, Pan Z, Coggeshall KM, Farris AD. IL-6 deficiency corrects nephritis, lymphocyte abnormalities and secondary Sjogren’s features in Sle1.Yaa lupus-prone mice. Arthritis Rheumatol 2014. [Abstract] EPub

Maiti AK, Kim-Howard X, Motghare P, Pradhan V, Chua KH, Sun C, Arango-Guerrero MT, Ghosh K, Niewold TB, Harley JB, Anaya JM, Looger LL, Nath SK. Combined protein- and nucleic acid-level effects of rs1143679 (R77H), a lupus-predisposing variant within ITGAM. Hum Mol Genet 2014. [Abstract] EPub

Mayes MD, Bossini-Castillo L, Gorlova O, Martin JE, Zhou X, Chen WV, Assassi S, Ying J, Tan FK, Arnett FC, Reveille JD, Guerra S, Teruel M, Carmona FD, Gregersen PK, Lee AT, López-Isac E, Ochoa E, Carreira P, Simeón CP, Castellvi I, González-Gay MA, Spanish Scleroderma Group, Zhernakova A, Padyukov L, Alarcón-Riquelme M, Wijmenga C, Brown M, Beretta L, Riemekasten G, Witte T, Hunzelmann N, Kreuter A, Distler JH, Voskuyl AE, Schuerwegh AJ, Hesselstrand R, Nordin A, Airo P, Lunardi C, Shiels P, van Laar JM, Herrick A, Worthington J, Denton C, Wigley FM, Hummers LK, Varga J, Hinchcliff ME, Baron M, Hudson M, Pope JE, Furst DE, Khanna D, Phillips K, Schiopu E, Segal BM, Molitor JA, Silver RM, Steen VD, Simms RW, Lafyatis RA, Fessler BJ, Frech TM, Alkassab F, Docherty P, Kaminska E, Khalidi N, Jones HN, Markland J, Robinson D, Broen J, Radstake TR, Fonseca C, Koeleman BP, Martin J. Immunochip analysis identifies multiple susceptibility loci for systemic sclerosis. Am J Hum Genet 94:47-61, 2014. [Abstract]

McFarland KN, Liu J, Landrian I, Zeng D, Raskin S, Moscovich M, Gatto EM, Ochoa A, Teive HA, Rasmussen A, Ashizawa T. Repeat interruptions in spinocerebellar ataxia type 10 expansions are strongly associated with epileptic seizures. Neurogenetics 15:59-64, 2014. [Abstract]

Molineros JE, Chua KH, Sun C, Lian LH, Motghare P, Kim-Howard X, Nath SK. Evaluation of SLE susceptibility genes in Malaysians. Autoimmune Dis 2014:305436, 2014. [Abstract]

Morris DL, Fernando MM, Taylor KE, Chung SA, Nititham J, Alarcón-Riquelme ME, Barcellos LF, Behrens TW, Cotsapas C, Gaffney PM, Graham RR, Pons-Estel BA, Gregersen PK, Harley JB, Hauser SL, Hom G, Langefeld CD, Noble JA, Rioux JD, Seldin MF, Systemic Lupus Erythematosus Genetics Consortium, Vyse TJ, Criswell LA. MHC associations with clinical and autoantibody manifestations in European SLE. Genes Immun 15:210-217, 2014. [Abstract]

* Munroe ME, Vista ES, Guthridge JM, Thompson LF, Merrill JT, James JA. Proinflammatory adaptive cytokine and shed tumor necrosis factor receptors are elevated preceding systemic lupus erythematosus disease flare. Arthritis Rheumatol 66:1888-1899, 2014. [Abstract]

Nackiewicz D, Dey P, Szczerba B, Mohammad S, Kaplan JL, McNamara CA, Deshmukh US, Bagavant H. Inhibitor of Differentiation 3, a transcription factor, regulates hyperlipidemia-associated kidney disease. Nephron Exp Nephrol 126:141-147, 2014. [Abstract]

Nesin V, Wiley G, Kousi M, Ong EC, Lehmann T, Nicholl DJ, Suri M, Shahrizaila N, Katsanis N, Gaffney PM, Wierenga KJ, Tsiokas L. Activating mutations in STIM1 and ORAI1 cause overlapping syndromes of tubular myopathy and congenital miosis. Proc Natl Acad Sci U S A 111:4197-4202, 2014. [Abstract]

Oparina NY, Delgado-Vega AM, Martinez-Bueno M, Magro-Checa C, Fernandez C, Castro RO, Pons-Estel BA, D’Alfonso S, Sebastiani GD, Witte T, Lauwerys BR, Endreffy E, Kovacs L, Escudero A, Lopez-Pedrera C, Vasconcelos C, da Silva BM, Frostegard J, Truedsson L, Martin J, Raya E, Ortego-Centeno N, de Los Angeles AM, de Ramon GE, Palma MJ, Alarcon-Riquelme ME, Kozyrev SV. PXK locus in systemic lupus erythematosus: fine mapping and functional analysis reveals novel susceptibility gene ABHD6. Ann Rheum Dis 2014. [Abstract] EPub

Rasmussen A, Ice JA, Li H, Grundahl K, Kelly JA, Radfar L, Stone DU, Hefner KS, Anaya JM, Rohrer M, Gopalakrishnan R, Houston GD, Lewis DM, Chodosh J, Harley JB, Hughes P, Maier-Moore JS, Montgomery CG, Rhodus NL, Farris AD, Segal BM, Jonsson R, Lessard CJ, Scofield RH, Sivils KL. Comparison of the American-European Consensus Group Sjogren’s syndrome classification criteria to newly proposed American College of Rheumatology criteria in a large, carefully characterised SICCA cohort. Ann Rheum Dis 73:31-38, 2014. [Abstract]

Ritterhouse LL, Lu R, Shah HB, Robertson JM, Fife DA, Maecker HT, Du H, Fathman CG, Chakravarty EF, Scofield RH, Kamen DL, Guthridge JM, James JA. Vitamin D deficiency in a multiethnic healthy control cohort and altered immune response in vitamin D deficient European-American healthy controls. PLoS One 9:e94500, 2014. [Abstract]

Segal B, Pogatchnik B, Rhodus N, Sivils KM, McElvain G, Solid C. Pain in primary Sjogren’s syndrome: the role of catastrophizing and negative illness perceptions. Scand J Rheumatol 43:234-241, 2014. [Abstract]

Seror R, Theander E, Brun JG, Ramos-Casals M, Valim V, Dorner T, Bootsma H, Tzioufas A, Solans-Laque R, Mandl T, Gottenberg JE, Hachulla E, Sivils KL, Ng WF, Fauchais AL, Bombardieri S, Valesini G, Bartoloni E, Saraux A, Tomsic M, Sumida T, Nishiyama S, Caporali R, Kruize AA, Vollenweider C, Ravaud P, Vitali C, Mariette X, Bowman SJ, on behalf of the EULAR Sjogren’s Task Force. Validation of EULAR primary Sjogren’s syndrome disease activity (ESSDAI) and patient indexes (ESSPRI). Ann Rheum Dis 2014. [Abstract] EPub

Shah D, Mahajan N, Sah S, Nath SK, Paudyal B. Oxidative stress and its biomarkers in systemic lupus erythematosus. J Biomed Sci 21:23, 2014. [Abstract]

Shen W, Gao Y, Lu B, Zhang Q, Hu Y, Chen Y. Negatively regulating TLR4/NF-kappaB signaling via PPARalpha in endotoxin-induced uveitis. Biochim Biophys Acta 2014. [Abstract] EPub

Shen W, Gao Y, Lu B, Zhang Q, Hu Y, Chen Y. Negatively Regulating TLR4/NF-kappaB signaling via PPARalpha in Endotoxin-induced Uveitis. Biochim Biophys Acta 2014. [Abstract] EPub

Szymula A, Rosenthal J, Szczerba BM, Bagavant H, Fu SM, Deshmukh US. T cell epitope mimicry between Sjogren’s syndrome Antigen A (SSA)/Ro60 and oral, gut, skin and vaginal bacteria. Clin Immunol 152:1-9, 2014. [Abstract]

* Thanou A, Chakravarty E, James JA, Merrill JT. How should lupus flares be measured? Deconstruction of the Safety of Estrogen in Lupus Erythematosus National Assessment-Systemic Lupus Erythematosus Disease Activity Index flare index. Rheumatology (Oxford) 2014. [Abstract] EPub

* Thanou A, Merrill JT. Treatment of systemic lupus erythematosus: new therapeutic avenues and blind alleys. Nat Rev Rheumatol 10:23-34, 2014. [Abstract]

Tucsek Z, Toth P, Tarantini S, Sosnowska D, Gautam T, Warrington JP, Giles CB, Wren JD, Koller A, Ballabh P, Sonntag WE, Ungvari Z, Csiszar A. Aging exacerbates obesity-induced cerebromicrovascular rarefaction, neurovascular uncoupling, and cognitive decline in mice. J Gerontol A Biol Sci Med Sci 2014. [Abstract] EPub

Williams M, Chakravarty EF. Rheumatoid arthritis and pregnancy: impediments to optimal management of both biologic use before, during and after pregnancy. Curr Opin Rheumatol 26:341-346, 2014. [Abstract]

Young K, Terrell D, Guthridge J, Kamen D, Gilkeson G, Karp D, Ishimori M, Weisman M, Holers V, Harley J, Norris J, James J. Smoking is not associated with autoantibody production in systemic lupus erythematosus patients, unaffected first-degree relatives, nor healthy controls. Lupus  23:360-369,2014. [Abstract]

Zhou XJ, Nath SK, Qi YY, Cheng FJ, Yang HZ, Zhang Y, Yang W, Ma JY, Zhao MH, Shen N, Zhang H. Identification of MTMR3 as a novel susceptibility gene for lupus nephritis in northern Han Chinese by shared-gene analysis with IgA nephropathy. Arthritis Rheumatol 2014. [Abstract] EPub

Cardiovascular Biology Research Program

Chen H, Griffin C, Xia L, Srinivasan RS. Molecular and cellular mechanisms of lymphatic vascular maturation. Microvasc Res 2014. [Abstract] EPub

Herzog BH, Fu J, Xia L. Mucin-type O-glycosylation is critical for vascular integrity. Glycobiology 2014. [Abstract] EPub

Hess PR, Rawnsley DR, Jakus Z, Yang Y, Sweet DT, Fu J, Herzog B, Lu M, Nieswandt B, Oliver G, Makinen T, Xia L, Kahn ML. Platelets mediate lymphovenous hemostasis to maintain blood-lymphatic separation throughout life. J Clin Invest 124:273-284, 2014. [Abstract]

Johansson ME, Gustafsson JK, Holmen-Larsson J, Jabbar KS, Xia L, Xu H, Ghishan FK, Carvalho FA, Gewirtz AT, Sjovall H, Hansson GC. Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis. Gut 63:281-291, 2014. [Abstract]

Keshari RS, Silasi-Mansat R, Zhu H, Popescu NI, Peer G, Chaaban H, Lambris JD, Polf H, Lupu C, Kinasewitz G, Lupu F. Acute lung injury and fibrosis in a baboon model of Escherichia coli sepsis. Am J Respir Cell Mol Biol 50:439-450, 2014. [Abstract]

Lee MY, Skoura A, Park EJ, Landskroner-Eiger S, Jozsef L, Luciano AK, Murata T, Pasula S, Dong Y, Bouaouina M, Calderwood DA, Ferguson SM, De CP, Sessa WC. Dynamin 2 regulation of integrin endocytosis, but not VEGF signaling, is crucial for developmental angiogenesis. Development 141:1465-1472, 2014. [Abstract]

* Lupu F, Keshari RS, Lambris JD, Coggeshall KM. Crosstalk between the coagulation and complement systems in sepsis. Thromb Res 133 Suppl 1:S28-S31, 2014. [Abstract]

McBride J, Jenkins A, Liu X, Zhang B, Lee K, Berry WL, Janknecht R, Griffin C, Aston CE, Lyons T, Tomasek JJ, Ma JX. Elevated circulation levels of an anti-angiogenic SERPIN in patients with diabetic microvascular complications impair wound healing through suppression of Wnt signaling. J Invest Dermatol 134:1725-1734, 2014. [Abstract]

Pan Y, Wang WD, Yago T. Transcriptional regulation of podoplanin expression by Prox1 in lymphatic endothelial cells. Microvasc Res 2014. [Abstract] EPub

Perez-Munoz M, Bergstrom K, Peng V, Schmaltz R, Jimenez-Cardona R, Marsteller N, McGee S, Clavel T, Ley R, Xia L, Peterson D. Discordance between changes in the gut microbiota and pathogenicity in a mouse model of spontaneous colitis. Gut Microbes 5: 2014. [Abstract] EPub

Risitano AM, Ricklin D, Huang Y, Reis ES, Chen H, Ricci P, Lin Z, Pascariello C, Raia M, Sica M, Del VL, Pane F, Lupu F, Notaro R, Resuello RR, Deangelis RA, Lambris JD. Peptide inhibitors of C3 activation as a novel strategy of complement inhibition for the treatment of paroxysmal nocturnal hemoglobinuria. Blood 123:2094-2101, 2014. [Abstract]

Sommer F, Adam N, Johansson ME, Xia L, Hansson GC, Backhed F. Altered mucus glycosylation in core 1 o-glycan-deficient mice affects microbiota composition and intestinal architecture. PLoS One 9:e85254, 2014. [Abstract]

Tessneer KL, Pasula S, Cai X, Dong Y, McManus J, Liu X, Yu L, Hahn S, Chang B, Chen Y, Griffin C, Xia L, Adams RH, Chen H. Genetic reduction of vascular endothelial growth factor receptor 2 rescues aberrant angiogenesis caused by epsin deficiency. Arterioscler Thromb Vasc Biol 34:331-337, 2014. [Abstract]

Yao L, Herlea-Pana O, Heuser-Baker J, Chen Y, Barlic-Dicen J. Roles of the chemokine system in development of obesity, insulin resistance, and cardiovascular disease. J Immunol Res 2014:181450, 2014. [Abstract]

Cell Cycle and Cancer Biology Research Program

Bugreev DV, Huang F, Mazina OM, Pezza RJ, Voloshin ON, Daniel Camerini-Otero R, Mazin AV. HOP2-MND1 modulates RAD51 binding to nucleotides and DNA. Nat Commun 5:4198, 2014. [Abstract]

Moktan H, Guiraldelli MF, Eyster CA, Zhao W, Lee CY, Mather T, Camerini-Otero RD, Sung P, Zhou DH, Pezza RJ. Solution structure and DNA-binding properties of the winged helix domain of the meiotic recombination HOP2 protein. J Biol Chem 2014. [Abstract] EPub

Obeso D, Pezza RJ, Dawson D. Couples, pairs, and clusters: mechanisms and implications of centromere associations in meiosis. Chromosoma 123:43-55, 2014. [Abstract]

Pezza RJ, Voloshin ON, Volodin AA, Boateng KA, Bellani MA, Mazin AV, Camerini-Otero RD. The dual role of HOP2 in mammalian meiotic homologous recombination. Nucleic Acids Res 42:2346-2357, 2014. [Abstract]

Sau S, Conrad MN, Lee CY, Kaback DB, Dresser ME, Jayaram M. A selfish DNA element engages a meiosis-specific motor and telomeres for germ-line propagation. J Cell Biol 205:643-661, 2014. [Abstract]

Sivakumar S, Daum JR, Gorbsky GJ. Live–cell fluorescence imaging for phenotypic analysis of mitosis. Methods Mol Biol 1170:549-562, 2014. [Abstract]

Sivakumar S, Daum JR, Tipton AR, Rankin S, Gorbsky GJ. The spindle and kinetochore-associated (Ska) complex enhances binding of the anaphase-promoting complex/cyclosome (APC/C) to chromosomes and promotes mitotic exit. Mol Biol Cell  25:594-605, 2014. [Abstract]

Zhao W, Saro D, Hammel M, Kwon Y, Xu Y, Rambo RP, Williams GJ, Chi P, Lu L, Pezza RJ, Camerini-Otero RD, Tainer JA, Wang HW, Sung P. Mechanistic insights into the role of Hop2-Mnd1 in meiotic homologous DNA pairing. Nucleic Acids Res 42:906-917, 2014. [Abstract]

Clinical Pharmacology Research Program

Bourre-Tessier J, Urowitz MB, Clarke AE, Bernatsky S, Krantz MJ, Huynh T, Joseph L, Belisle P, Bae SC, Hanly JG, Wallace DJ, Gordon C, Isenberg D, Rahman A, Gladman DD, Fortin PR, Merrill JT, Romero-Diaz J, Sanchez-Guerrero J, Fessler B, Alarcon GS, Steinsson K, Bruce IN, Ginzler E, Dooley MA, Nived O, Sturfelt G, Kalunian K, Ramos-Casals M, Petri M, Zoma A, SLICC investigators, Pineau CA. Electrocardiographic findings in systemic lupus erythematosus: Data from an international inception cohort. Arthritis Care Res (Hoboken) 2014. [Abstract] EPub

Bruce IN, O’Keeffe AG, Farewell V, Hanly JG, Manzi S, Su L, Gladman DD, Bae SC, Sanchez-Guerrero J, Romero-Diaz J, Gordon C, Wallace DJ, Clarke AE, Bernatsky S, Ginzler EM, Isenberg DA, Rahman A, Merrill JT, Alarcon GS, Fessler BJ, Fortin PR, Petri M, Steinsson K, Dooley MA, Khamashta MA, Ramsey-Goldman R, Zoma AA, Sturfelt GK, Nived O, Aranow C, Mackay M, Ramos-Casals M, Van Vollenhoven RF, Kalunian KC, Ruiz-Irastorza G, Lim S, Kamen DL, Peschken CA, Inanc M, Urowitz MB. Factors associated with damage accrual in patients with systemic lupus erythematosus: results from the Systemic Lupus International Collaborating Clinics (SLICC) Inception Cohort. Ann Rheum Dis 2014. [Abstract] EPub

* Freedman BI, Langefeld CD, Andringa KK, Croker JA, Williams AH, Garner NE, Birmingham DJ, Hebert LA, Hicks PJ, Segal MS, Edberg JC, Brown EE, Alarcon GS, Costenbader KH, Comeau ME, Criswell LA, Harley JB, James JA, Kamen DL, Lim SS, Merrill JT, Sivils KL, Niewold TB, Patel NM, Petri M, Ramsey-Goldman R, Reveille JD, Salmon JE, Tsao BP, Gibson KL, Byers JR, Vinnikova AK, Lea JP, Julian BA, Kimberly RP. Lupus nephritis-end-stage renal disease consortium. end-stage renal disease in African Americans with lupus nephritis is associated with APOL1. Arthritis Rheumatol 66:390-396, 2014. [Abstract]

Furie R, Nicholls K, Cheng TT, Houssiau F, Burgos-Vargas R, Chen SL, Hillson JL, Meadows-Shropshire S, Kinaszczuk M, Merrill JT. Efficacy and safety of abatacept in lupus nephritis: a twelve-month, randomized, double-blind study. Arthritis Rheumatol 66:379-389, 2014. [Abstract]

Ginzler EM, Wallace DJ, Merrill JT, Furie RA, Stohl W, Chatham WW, Weinstein A, McKay JD, McCune WJ, Zhong ZJ, Freimuth WW, Petri MA, the LBSL02/99 Study Group. Disease control and safety of Belimumab plus standard therapy over 7 years in patients with systemic lupus erythematosus. J Rheumatol 41:300-309, 2014. [Abstract]

* Guthridge JM, Lu R, Sun H, Sun C, Wiley GB, Dominguez N, Macwana SR, Lessard CJ, Kim-Howard X, Cobb BL, Kaufman KM, Kelly JA, Langefeld CD, Adler AJ, Harley IT, Merrill JT, Gilkeson GS, Kamen DL, Niewold TB, Brown EE, Edberg JC, Petri MA, Ramsey-Goldman R, Reveille JD, Vila LM, Kimberly RP, Freedman BI, Stevens AM, Boackle SA, Criswell LA, Vyse TJ, Behrens TW, Jacob CO, Alarcon-Riquelme ME, Sivils KL, Choi J, Joo YB, Bang SY, Lee HS, Bae SC, Shen N, Qian X, Tsao BP, Scofield RH, Harley JB, Webb CF, Wakeland EK, James JA, Nath SK, Graham RR, Gaffney PM. Two functional lupus-associated BLK promoter variants control cell-type- and developmental-stage-specific transcription.. Am J Hum Genet 94:586-598, 2014. [Abstract]

Kivitz A, Olech E, Borofsky M, Zazueta BM, Navarro-Sarabia F, Radominski SC, Merrill JT, Rowell L, Nasmyth-Miller C, Bao M, Wright S, Pope JE. Subcutaneous Tocilizumab vs placebo in combination with disease modifying antirheumatic drugs in patients with rheumatoid arthritis. Arthritis Care Res (Hoboken) 2014. [Abstract] EPub

Lertratanakul A, Wu P, Dyer A, Urowitz M, Gladman D, Fortin P, Bae SC, Gordon C, Clarke A, Bernatsky S, Hanly JG, Isenberg D, Rahman A, Merrill J, Wallace DJ, Ginzler E, Khamashta M, Bruce I, Nived O, Sturfelt G, Steinsson K, Manzi S, Dooley MA, Kalunian K, Petri M, Aranow C, Font J, van Vollenhoven R, Stoll T, Ramsey-Goldman R. 25-Hydroxyvitamin D and cardiovascular disease in patients with systemic lupus erythematosus: Data from a large international inception cohort. Arthritis Care Res (Hoboken) 2014. [Abstract] EPub

* Munroe ME, Vista ES, Guthridge JM, Thompson LF, Merrill JT, James JA. Proinflammatory adaptive cytokine and shed tumor necrosis factor receptors are elevated preceding systemic lupus erythematosus disease flare. Arthritis Rheumatol 66:1888-1899, 2014. [Abstract]

Parker B, Urowitz MB, Gladman DD, Lunt M, Donn R, Bae SC, Sanchez-Guerrero J, Romero-Diaz J, Gordon C, Wallace DJ, Clarke AE, Bernatsky S, Ginzler EM, Isenberg DA, Rahman A, Merrill JT, Alarcon GS, Fessler BJ, Fortin PR, Hanly JG, Petri M, Steinsson K, Dooley MA, Manzi S, Khamashta MA, Ramsey-Goldman R, Zoma AA, Sturfelt GK, Nived O, Aranow C, Mackay M, Ramos-Casals M, Van Vollenhoven RF, Kalunian KC, Ruiz-Irastorza G, Lim SS, Kamen DL, Peschken CA, Inanc M, Bruce IN. Impact of early disease factors on metabolic syndrome in systemic lupus erythematosus: data from an international inception cohort. Ann Rheum Dis 2014. [Abstract] EPub

* Thanou A, Chakravarty E, James JA, Merrill JT. How should lupus flares be measured? Deconstruction of the of the safety of estrogen in Lupus Erythematosus National Assessment-Systemic Lupus Erythematosus Disease Activity Index flare index. Rheumatology (Oxford) 2014. [Abstract] EPub

* Thanou A, Merrill JT. Treatment of systemic lupus erythematosus: new therapeutic avenues and blind alleys. Nat Rev Rheumatol 10:23-34, 2014. [Abstract]

Urowitz M, Gladman DD, Ibanez D, Sanchez-Guerrero J, Bae SC, Gordon C, Fortin PR, Clarke A, Bernatsky S, Hanly JG, Wallace DJ, Isenberg D, Rahman A, Merrill J, Ginzler E, Alarcon GS, Fessler B, Khamashta M, Steinsson K, Petri M, Dooley M, Bruce IN, Manzi S, Sturfelt G, Nived O, Ramsey-Goldman R, Zoma A, Maddison P, Kalunian K, Van Vollenhoven R., Aranow C, Romero-Diaz J, Stoll T. Changes in quality of life in the first 5 years of disease in a multicentre cohort of patients with systemic lupus erythematosus (SLE). Arthritis Care Res (Hoboken) 2014. [Abstract] EPub

Urowitz MB, Gladman DD, Ibanez D, Sanchez-Guerrero J, Romero-Diaz J, Gordon C, Bae SC, Clarke AE, Bernatsky S, Fortin PR, Hanly JG, Isenberg D, Rahman A, Wallace DJ, Ginzler E, Petri M, Bruce IN, Merrill JT, Nived O, Sturfelt G, Dooley MA, Alarcon GS, Fessler B, Steinsson K, Ramsey-Goldman R, Zoma A, Khamashta M, Manzi S, Van Vollenhoven R., Ramos-Casals M, Aranow C, Stoll T. American College of Rheumatology criteria at inception, and accrual over 5 years in the SLICC inception cohort. J Rheumatol 41:875-880, 2014. [Abstract]

Coagulation Biology Laboratory

Esmon C. Targeting factor Xa and thrombin: impact on coagulation and beyond. Thromb Haemost 111:625-633, 2014. [Abstract]

Senchenkova EY, Russell J, Esmon CT, Granger DN. Roles of coagulation and fibrinolysis in angiotensin II enhanced microvascular thrombosis. Microcirculation 2014. [Abstract] EPub

Schouten M, de Boer JD, Kager LM, Roelofs JJ, Meijers JC, Esmon CT, Levi M, Van’t Veer C, van der Poll T. The endothelial protein C receptor impairs the antibacterial response in murine pneumococcal pneumonia and sepsis. Thromb Haemost 111:970-980, 2014. [Abstract]

Sundaram J, Keshava S, Gopalakrishnan R, Esmon CT, Pendurthi UR, Rao LV. Factor VIIa binding to endothelial cell protein C receptor protects vascular barrier integrity in vivo. J Thromb Haemost 12:690-700, 2014. [Abstract]

Experimental Therapeutics

Choi CH, Du X, Floyd RA, Kopke RD. Therapeutic effects of orally administrated antioxidant drugs on acute noise induced hearing loss. Free Radic Res  48:264-272,2014. [Abstract]

Lu J, Li W, Du X, Ewert DL, West MB, Stewart C, Floyd RA, Kopke RD. Antioxidants reduce cellular and functional changes induced by intense noise in the inner ear and cochlear nucleus. J Assoc Res Otolaryngol 15:353-372, 2014. [Abstract]

Free Radical Biology and Aging Research Program

Debalsi KL, Wong KE, Koves TR, Slentz DH, Seiler SE, Wittmann AH, Ilkayeva OR, Stevens RD, Perry CG, Lark DS, Hui ST, Szweda L, Neufer PD, Muoio DM. Targeted  metabolomics connects thioredoxin-interacting protein (TXNIP) to mitochondrial fuel selection and regulation of specific oxidoreductase enzymes in skeletal muscle. J Biol Chem 289:8106-8120,2014. [Abstract]

* Lim HY, Wang W, Chen J, Ocorr K, Bodmer R. ROS Regulate cardiac function via a distinct paracrine mechanism. Cell Rep 7:35-44, 2014. [Abstract]

Nguyen L, Plafker KS, Starnes A, Cook MJ, Klevit RE, Plafker SM. The Ubiquitin conjugating enzyme, UBCM2, is restricted to monoubiquitylation by a two-fold mechanism that involves backside residues of the E2 and LYS-48 of ubiquitin. Biochemistry 2014. [Abstract] EPub

Puente BN, Kimura W, Muralidhar SA, Moon J, Amatruda JF, Phelps KL, Grinsfelder D, Rothermel BA, Chen R, Garcia JA, Santos CX, Thet S, Mori E, Kinter MT, Rindler PM, Zacchigna S, Mukherjee S, Chen DJ, Mahmoud AI, Giacca M, Rabinovitch PS, Aroumougame A, Shah AM, Szweda LI, Sadek HA. The oxygen-rich postnatal environment induces cardiomyocyte cell-cycle arrest through DNA damage response. Cell 157:565-579, 2014. [Abstract]

Pulliam DA, Deepa SS, Liu Y, Hill S, Lin AL, Bhattacharya A, Shi Y, Sloane L, Viscomi C, Zeviani M, Van Remmen H. Complex IV deficient Surf1-/- mice initiate mitochondrial stress responses. Biochem J 2014. [Abstract] EPub

Shi Y, Ivannikov MV, Walsh ME, Liu Y, Zhang Y, Jaramillo CA, Macleod GT, Van Remmen H. The lack of CuZnSOD leads to impaired neurotransmitter release, neuromuscular junction destabilization and reduced muscle strength in mice. PLoS One 9:e100834, 2014. [Abstract]

Genetic Models of Disease Research Program

Hoover CM, Edwards SL, Yu SC, Kittelmann M, Richmond JE, Eimer S, Yorks RM, Miller KG. A  novel CaM kinase II pathway controls the location of neuropeptide release from Caenorhabditis elegans. Genetics 196:745-765, 2014. [Abstract]

Immunobiology and Cancer Research Program

Coffey F, Lee SY, Buus TB, Lauritsen JP, Wong GW, Joachims ML, Thompson LF, Zuniga-Pflucker JC, Kappes DJ, Wiest DL. The TCR ligand-inducible expression of CD73 marks gammadelta lineage commitment and a metastable intermediate in effector specification. J Exp Med 211:329-343, 2014. [Abstract]

Fenutria R, Martinez VG, Simoes I, Postigo J, Gil V, Martinez-Florensa M, Sintes J, Naves R, Cashman KS, Alberola-Ila J, Ramos-Casals M, Soldevila G, Raman C, Merino J, Merino R, Engel P, Lozano F. Transgenic expression of soluble human CD5 enhances experimentally-induced autoimmune and anti-tumoral immune responses. PLoS One 9:e84895, 2014. [Abstract]

* Guthridge JM, Lu R, Sun H, Sun C, Wiley GB, Dominguez N, Macwana SR, Lessard CJ, Kim-Howard X, Cobb BL, Kaufman KM, Kelly JA, Langefeld CD, Adler AJ, Harley IT, Merrill JT, Gilkeson GS, Kamen DL, Niewold TB, Brown EE, Edberg JC, Petri MA, Ramsey-Goldman R, Reveille JD, Vila LM, Kimberly RP, Freedman BI, Stevens AM, Boackle SA, Criswell LA, Vyse TJ, Behrens TW, Jacob CO, Alarcon-Riquelme ME, Sivils KL, Choi J, Joo YB, Bang SY, Lee HS, Bae SC, Shen N, Qian X, Tsao BP, Scofield RH, Harley JB, Webb CF, Wakeland EK, James JA, Nath SK, Graham RR, Gaffney PM. Two functional lupus-associated BLK promoter variants control cell-type- and developmental-stage-specific transcription. Am J Hum Genet 94:586-598, 2014. [Abstract]

Iida R, Welner RS, Zhao W, Alberola-Ila J, Medina KL, Zhao ZJ, Kincade PW. Stem and progenitor cell subsets are affected by JAK2 signaling and can be monitored by flow cytometry. PLoS One 9:e93643, 2014. [Abstract]

* Lim HY, Wang W, Chen J, Ocorr K, Bodmer R. ROS Regulate cardiac function via a distinct paracrine mechanism. Cell Rep 7:35-44, 2014. [Abstract]

Liu C, Wang HC, Yu S, Jin R, Tang H, Liu YF, Ge Q, Sun XH, Zhang Y. Id1 expression promotes T regulatory cell differentiation by facilitating TCR costimulation. J Immunol 2014. [Abstract] EPub

* Lupu F, Keshari RS, Lambris JD, Coggeshall KM. Crosstalk between the coagulation and complement systems in sepsis. Thromb Res 133 Suppl 1:S28-S31, 2014. [Abstract]

* Maier-Moore JS, Horton CG, Mathews SA, Confer AW, Lawrence C, Pan Z, Coggeshall KM, Farris AD. IL-6 deficiency corrects nephritis, lymphocyte abnormalities and secondary Sjogren’s features in Sle1.Yaa lupus-prone mice. Arthritis Rheumatol 2014. [Abstract] EPub

Popowski M, Templeton TD, Lee BK, Rhee C, Li H, Miner C, Dekker JD, Orlanski S, Bergman Y, Iyer VR, Webb CF, Tucker H. Bright/Arid3A acts as a barrier to somatic cell reprogramming through direct regulation of Oct4, Sox2, and Nanog. Stem Cell Reports 2:26-35, 2014. [Article]

Qin L, Thompson LF, Kuzel TM, Zhang B. Requirement of NK cells for selective A2A receptor blockade to suppress CD73(+) tumor metastasis. Immunotherapy 6:19-21, 2014. [Abstract]

Ratliff ML, Templeton TD, Ward JM, Webb CF. The Bright side of hematopoiesis: regulatory roles of ARID3a/Bright in human and mouse hematopoiesis. Front Immunol 5:113, 2014. [Abstract]

Vadillo E, Dorantes-Acosta E, Arriaga-Pizano L, Chavez-Gonzalez A, Reyes-Maldonado E, Garrett KP, Mayani H, Kincade PW, Pelayo R. Adult, but not neonatal, human lymphoid progenitors respond to TLR9 ligation by producing functional NK-like cells. Exp Hematol 2014. [Abstract] EPub

Welner RS, Kincade PW. 9-1-1: HSCs respond to emergency calls. Cell Stem Cell 14:415-416, 2014. [Abstract]

 

* Indicates publications by more than one department or group.

 

 

 

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