2012 Scientific Publications

OMRF Publications for 2012

Advanced Magnetic Resonance Center

Doblas S, He T, Saunders D, Hoyle J, Smith N, Pye Q, Lerner M, Jensen RL, Towner RA. In vivo characterization of several rodent glioma models by (1) H MRS. NMR Biomed 25:685-694, 2012. [Abstract]

Li X, McClellan ME, Tanito M, Garteiser P, Towner R, Bissig D, Berkowitz BA, Fliesler SJ, Woodruff ML, Fain GL, Birch DG, Khan MS, Ash JD, Elliott MH. Loss of caveolin-1 impairs retinal function due to a disturbance of the subretinal microenvironment. J Biol Chem 287:16424-16434, 2012. [Abstract]

* Pasula S, Cai X, Dong Y, Messa M, McManus J, Chang B, Liu X, Zhu H, Mansat RS, Yoon SJ, Hahn S, Keeling J, Saunders D, Ko G, Knight J, Newton G, Luscinskas F, Sun X, Towner R, Lupu F, Xia L, Cremona O, De Camilli P, Min W, Chen H. Endothelial epsin deficiency decreases tumor growth by enhancing VEGF signaling. J Clin Invest 122:4424-4438, 2012. [Abstract]

Tesiram YA, Lerner M, Stewart C, Njoku C, Brackett DJ. Utility of nuclear magnetic resonance spectroscopy for pancreatic cancer studies. Pancreas 41:474-480, 2012. [Abstract]

* Towner RA, Smith N, Saunders D, Henderson M, Downum K, Lupu F, Silasi-Mansat R, Ramirez DC, Gomez-Mejiba SE, Bonini MG, Ehrenshaft M, Mason RP. In vivo imaging of immunospin-trapped radicals with molecular magnetic resonance imaging in a mouse diabetes model. Diabetes 61:2405-2413, 2012. [Abstract]

Arthritis and  Clinical Immunology Research Program

Adrianto I, Montgomery C. Estimating allele frequencies. Methods Mol Biol 850:59-76, 2012. [Abstract]

Adrianto I, Lin CP, Hale JJ, Levin AM, Datta I, Parker R, Adler A, Kelly JA, Kaufman KM, Lessard CJ, Moser KL, Kimberly RP, Harley JB, Iannuzzi MC, Rybicki BA, Montgomery CG. Genome-wide association study of African and European Americans implicates multiple shared and ethnic specific loci in sarcoidosis susceptibility. PLoS One 7:e43907, 2012. [Abstract]

* Adrianto I, Wang S, Wiley GB, Lessard CJ, Kelly JA, Adler AJ, Glenn SB, Williams AH, Ziegler JT, Comeau ME, Marion MC, Wakeland BE, Liang C, Kaufman KM, Guthridge JM, Alarcón-Riquelme ME, BIOLUPUS and GENLES Networks, Alarcón GS, Anaya JM, Bae SC, Kim JH, Joo YB, Boackle SA, Brown EE, Petri MA, Ramsey-Goldman R, Reveille JD, Vila LM, Criswell LA, Edberg JC, Freedman BI, Gilkeson GS, Jacob CO, James JA, Kamen DL, Kimberly RP, Martin J, Merrill JT, Niewold TB, Pons-Estel BA, Scofield RH, Stevens AM, Tsao BP, Vyse TJ, Langefeld CD, Harley JB, Wakeland EK, Moser KL, Montgomery CG, Gaffney PM. Association of two independent functional risk haplotypes in TNIP1 with systemic lupus erythematosus. Arthritis Rheum 64:3695-3705, 2012. [Abstract]

Anaya JM, Kim-Howard X, Prahalad S, Chernavsky A, Canas C, Rojas-Villarraga A, Bohnsack J, Jonsson R, Bolstad AI, Brun JG, Cobb B, Moser KL, James JA, Harley JB, Nath SK. Evaluation of genetic association between an ITGAM non-synonymous SNP (rs1143679) and multiple autoimmune diseases. Autoimmun Rev 11:276-280, 2012.[Abstract]

Bajaña S, Roach K, Turner S, Paul J, Kovats S. IRF4 Promotes cutaneous dendritic cell migration to lymph nodes during homeostasis and inflammation. J Immunol 189:3368-3377,2012. [Abstract]

Bruner BF, Guthridge JM, Lu R, Vidal G, Kelly JA, Robertson JM, Kamen DL, Gilkeson GS, Neas BR, Reichlin M, Scofield RH, Harley JB, James JA. Comparison of autoantibody specificities between traditional and bead-based assays in a large, diverse collection of patients with systemic lupus erythematosus and family members. Arthritis Rheum 64:3677-3686, 2012. [Abstract]

* Castillejo-López C, Delgado-Vega AM, Wojcik J, Kozyrev SV, Thavathiru E, Wu YY, Sanchez E, Pöllmann D, Lopez-Egido JR, Fineschi S, Dominguez N, Lu R, James JA, Merrill JT, Kelly JA, Kaufman KM, Moser KL, Gilkeson G, Frostegård J, Pons-Estel BA, D’Alfonso S, Witte T, Callejas JL, Harley JB, Gaffney PM, Martin J, Guthridge JM, Alarcón-Riquelme ME. Genetic and physical interaction of the B-cell systemic lupus erythematosus-associated genes BANK1 and BLK. Ann Rheum Dis 71:136-142,2012. [Abstract]

Chakravarty E. Pre-disease pregnancy complications and systemic sclerosis: pathogenic or pre-clinical? Arthritis Res Ther 14:102, 2012. [Abstract]

Chakravarty EF, Hubert HB, Krishnan E, Bruce BB, Lingala VB, Fries JF. Lifestyle risk factors predict disability and death in healthy aging adults. Am J Med 125:190-197, 2012. [Abstract]

Clemmensen SN, Bohr CT, Rorvig S, Glenthoj A, Mora-Jensen H, Cramer EP, Jacobsen LC, Larsen MT, Cowland JB, Tanassi JT, Heegaard NH, Wren JD, Silahtaroglu AN, Borregaard N. Olfactomedin 4 defines a subset of human neutrophils. J Leukoc Biol 91:495-500, 2012.  [Abstract]

Clowse ME, Chakravarty E, Costenbader KH, Chambers C, Michaud K. The effects of infertility, pregnancy loss, and patient concerns on family size of women with rheumatoid arthritis and systemic lupus erythematosus. Arthritis Care Res (Hoboken) 64:668-674, 2012. [Abstract]

Costenbader KH, Gay S, Alarcón-Riquelme ME, Iaccarino L, Doria A. Genes, epigenetic regulation and environmental factors: which is the most relevant in developing autoimmune diseases? Autoimmun Rev 11:604-609, 2012. [Abstract]

Cruz-Tapias P, Rojas-Villarraga A, Maier-Moore S, Anaya JM. HLA and Sjogren’s syndrome susceptibility. A meta-analysis of worldwide studies. Autoimmun Rev 11:281-287, 2012. [Abstract]

Cuda CM, Li S, Liang S, Yin Y, Potula HH, Xu Z, Sengupta M, Chen Y, Butfiloski E, Baker H, Chang LJ, Dozmorov I, Sobel ES, Morel L. Pre-B Cell Leukemia Homeobox 1 Is Associated with Lupus Susceptibility in Mice and Humans. J Immunol  188:604-614,2012. [Abstract]

Delgado-Vega AM, Dozmorov MG, Quiros MB, Wu YY, Martinez-Garcia B, Kozyrev SV, Frostegard J, Truedsson L, de Ramon E, Gonzalez-Escribano MF, Ortego-Centeno N, Pons-Estel BA, D’Alfonso S, Sebastiani GD, Witte T, Lauwerys BR, Endreffy E, Kovacs L, Vasconcelos C, da Silva BM, Wren JD, Martin J, Castillejo-Lopez C, Alarcon-Riquelme ME. Fine mapping and conditional analysis identify a new mutation in the autoimmunity susceptibility gene BLK that leads to reduced half-life of the BLK protein. Ann Rheum Dis 71:1219-1226, 2012. [Abstract]

Dillon SP, Kurien BT, Li S, Bruner GR, Kaufman KM, Harley JB, Gaffney PM, Wallace DJ, Weisman MH, Scofield RH. Sex chromosome aneuploidies among men with systemic lupus erythematosus. J Autoimmun 38:J129-J134,2012. [Abstract]

Dozmorov MG, Cara LR, Giles CB, Wren JD. GenomeRunner: Automating genome exploration. Bioinformatics 28:419-420, 2012. [Abstract]

Gaddy JR, Khan ZZ, Chaser B, Scofield RH. Whipple’s disease diagnosis following the use of TNF-alpha blockade. Rheumatology (Oxford)51:946, 2012. [Abstract]

Gaddy JR, Vista ES, Robertson JM, Dedeke AB, Roberts VC, Klein WS, Levin JH, Mota FH, Cooper TM, Grim GA, Khan S, James JA. Rheumatic disease among Oklahoma tribal populations: A cross-sectional study. J Rheumatol 39:1934-1941, 2012. [Abstract]

Guthridge JM, Clark DN, Templeton A, Dominguez N, Lu R, Vidal GS, Kelly JA, Kauffman KM, Harley JB, Gaffney PM, James JA, Poole BD. Effects of IRF5 lupus risk haplotype on pathways predicted to influence B cell functions. J Biomed Biotechnol 2012:594056, 2012. [Abstract]

Hassed SJ, Wiley GB, Wang S, Lee JY, Li S, Xu W, Zhao ZJ, Mulvihill JJ, Robertson J, Warner J, Gaffney PM. RBPJ Mutations identified in two families affected by Adams-Oliver syndrome. Am J Hum Genet 91:391-395, 2012. [Abstract]

Horton CG, Farris AD. Toll-like receptors in systemic lupus erythematosus: potential targets for therapeutic intervention. Curr Allergy Asthma Rep 12:1-7,2012. [Abstract]

* Hughes T, Adler A, Kelly JA, Kaufman KM, Williams A, Langefeld CD, Brown EE, Alarcon GS, Kimberly RP, Edberg JC, Ramsey-Goldman R, Petri M, Boackle SA, Stevens AM, Reveille JD, Sanchez E, Martin J, Niewold TB, Vila LM, Scofield RH, Gilkeson GS, Gaffney PM, Criswell LA, Moser KL, Merrill JT, Jacob CO, Tsao BP, James JA, Vyse TJ, Alarcon-Riquelme ME, on behalf of the BIOLUPUS network, Harley JB, Richardson BC, Sawalha AH. Evidence for gene-gene epistatic interactions among susceptibility loci for systemic lupus erythematosus. Arthritis Rheum 64:485-492, 2012. [Abstract]

* Hughes T, Adler A, Merrill JT, Kelly JA, Kaufman KM, Williams A, Langefeld CD, Gilkeson GS, Sanchez E, Martin J, Boackle SA, Stevens AM, Alarcon GS, Niewold TB, Brown EE, Kimberly RP, Edberg JC, Ramsey-Goldman R, Petri M, Reveille JD, Criswell LA, Vila LM, Jacob CO, Gaffney PM, Moser KL, Vyse TJ, Alarcon-Riquelme ME, BIOLUPUS N, James JA, Tsao BP, Scofield RH, Harley JB, Richardson BC, Sawalha AH. Analysis of autosomal genes reveals gene-sex interactions and higher total genetic risk in men with systemic lupus erythematosus. Ann Rheum Dis 71:694-699, 2012. [Abstract]

Ice JA, Li H, Adrianto I, Lin PC, Kelly JA, Montgomery CG, Lessard CJ, Moser KL. Genetics of Sjögren’s syndrome in the genome-wide association era. J Autoimmun 39:57-63, 2012. [Abstract]

* Ichii M, Frank MB, Iozzo RV, Kincade PW. The canonical Wnt pathway shapes niches supportive for hematopoietic stem/progenitor cells. Blood 119:1683-1692, 2012.  [Abstract]

Jacob CO, Eisenstein M, Dinauer MC, Ming W, Liu Q, John S, Quismorio FP, Jr., Reiff A, Myones BL, Kaufman KM, McCurdy D, Harley JB, Silverman E, Kimberly RP, Vyse TJ, Gaffney PM, Moser KL, Klein-Gitelman M, Wagner-Weiner L, Langefeld CD, Armstrong DL, Zidovetzki R. Lupus-associated causal mutation in neutrophil cytosolic factor 2 (NCF2) brings unique insights to the structure and function of NADPH oxidase. Proc Natl Acad Sci U S A 109:E59-E67,2012. [Abstract]

James JA, Robertson JM. Lupus and Epstein-Barr. Curr Opin Rheumatol 24:383-388, 2012. [Abstract]

Joshi SK, Lang GA, Devera TS, Johnson AM, Kovats S, Lang ML. Differential contribution of dendritic cell CD1d to NKT cell-enhanced humoral immunity and CD8+ T cell activation. J Leukoc Biol 91:783-793,2012. [Abstract]

* Kim K, Brown EE, Choi CB, Alarcon-Riquelme ME, on behalf of BIOLUPUS, Kelly JA, Glenn SB, Ojwang JO, Adler A, Lee HS, Boackle SA, Criswell LA, Alarcon GS, Edberg JC, Stevens AM, Jacob CO, Gilkeson GS, Kamen DL, Tsao BP, Anaya JM, Guthridge JM, Nath SK, Richardson B, Sawalha AH, Kang YM, Shim SC, Suh CH, Lee SK, Kim CS, Merrill JT, Petri M, Ramsey-Goldman R, Vila LM, Niewold TB, Martin J, Pons-Estel BA, on behalf of GENLES, Vyse TJ, Freedman BI, Moser KL, Gaffney PM, Williams A, Comeau M, Reveille JD, James JA, Scofield RH, Langefeld CD, Kaufman KM, Harley JB, Kang C, Kimberly RP, Bae SC. Variation in the ICAM1-ICAM4-ICAM5 locus is associated with systemic lupus erythematosus susceptibility in multiple ancestries. Ann Rheum Dis 71:1809-1814,2012. [Abstract]

* Knowlton N, Wages J, Centola M, Alaupovic P. Apolipoprotein-defined lipoprotein abnormalities in rheumatoid arthritis patients and their potential impact on cardiovascular disease. Scand J Rheumatol 41:165-169, 2012. [Abstract]

* Knowlton N, Wages JA, Centola MB, Giles J, Bathon J, Quiroga C, Alaupovic P. Apolipoprotein B-containing lipoprotein subclasses as risk factors for cardiovascular disease in patients with rheumatoid arthritis. Arthritis Care Res (Hoboken) 64:993-1000, 2012. [Abstract]

Korte EA, Gaffney PM, Powell DW. Contributions of mass spectrometry-based proteomics to defining cellular mechanisms and diagnostic markers for systemic lupus erythematosus. Arthritis Res Ther 14:204, 2012. [Abstract]

Kovats S. Estrogen receptors regulate an inflammatory pathway of dendritic cell differentiation: Mechanisms and implications for immunity. Horm Behav 62:254-262, 2012. [Abstract]

Kozyrev SV, Bernal-Quiros M, Alarcón-Riquelme ME, Castillejo-Lopez C. The dual effect of the lupus-associated polymorphism rs10516487 on BANK1 gene expression and protein localization. Genes Immun 12:129-138, 2012.[Abstract]

Kurien BT, D’Souza A, Terzyan S, Scofield RH. Putative sequences on Ro60 three-dimensional structure accessible for 4-hydroxy-2-nonenal (HNE) modification compared to in vitro HNE modification of Ro60 sequences. Mol Immunol 50:185-192,2012. [Abstract]

Kurien BT, Dorri Y, Bachmann M, Scofield RH. Induction of anti-Ro60/anti-La by immunisation with spectrin and induction of anti-spectrin by immunisation with Ro60 and 4-hydroxy-2-nonenal-modified Ro60 immunisation. Clin Exp Rheumatol 30:886-893,2012. [Abstract]

* Lessard CJ, Adrianto I, Ice JA, Wiley GB, Kelly JA, Glenn SB, Adler AJ, Li H, Rasmussen A, Williams AH, Ziegler J, Comeau ME, Marion M, Wakeland BE, Liang C, Ramos PS, Grundahl KM, Gallant CJ, Marta E.Alarcon-Riquelme for the BIOLUPUS and GENLES Networks, Alarcon GS, Anaya JM, Bae SC, Boackle SA, Brown EE, Chang DM, Cho SK, Criswell LA, Edberg JC, Freedman BI, Gilkeson GS, Jacob CO, James JA, Kamen DL, Kimberly RP, Kim JH, Martin J, Merrill JT, Niewold TB, Park SY, Petri MA, Pons-Estel BA, Ramsey-Goldman R, Reveille JD, Scofield RH, Song YW, Stevens AM, Tsao BP, Vila LM, Vyse TJ, Yu CY, Guthridge JM, Kaufman KM, Harley JB, Wakeland EK, Langefeld CD, Gaffney PM, Montgomery CG, Moser KL. Identification of IRF8, TMEM39A, and IKZF3-ZPBP2 as susceptibility loci for systemic lupus erythematosus in a large-scale multiracial replication study. Am J Hum Genet 90:648-660, 2012. [Abstract]

Lessard CJ, Ice JA, Adrianto I, Wiley G, Kelly JA, Gaffney PM, Montgomery CG, Moser KL. The genomics of autoimmune disease in the era of genome-wide association studies and beyond. Autoimmun Rev 11:267-275, 2012.[Abstract]

* Lin CP, Adrianto I, Lessard CJ, Kelly JA, Kaufman KM, Guthridge JM, Freedman BI, Anaya JM, Alarcon-Riquelme ME, on behalf of the BIOLUPUS and GENLES Networks, Pons-Estel BA, Martin J, Glenn S, Adler A, Bae SC, Park SY, Bang SY, Song YW, Boackle SA, Brown EE, Edberg JC, Alarcon GS, Petri MA, Criswell LA, Ramsey-Goldman R, Reveille JD, Vila LM, Gilkeson GS, Kamen DL, Ziegler J, Jacob CO, Rasmussen A, James JA, Kimberly RP, Merrill JT, Niewold TB, Scofield RH, Stevens AM, Tsao BP, Vyse TJ, Langefeld CD, Moser KL, Harley JB, Gaffney PM, Montgomery CG. Role of MYH9 and APOL1 in African and non-African populations with lupus nephritis. Genes Immun 13:232-238, 2012. [Abstract]

Löfgren SE, Frostegård J, Truedsson L, Pons-Estel BA, D’Alfonso S, Witte T, Lauwerys BR, Endreffy E, Kovács L, Vasconcelos C, Martins da Silva B, Kozyrev SV, Alarcón-Riquelme ME. Genetic association of miRNA-146a with systemic lupus erythematosus in Europeans through decreased expression of the gene. Genes Immun 13:268-274,2012. [Abstract]

Lu R, Robertson JM, Bruner BF, Guthridge JM, Neas BR, Nath SK, Kelly JA, Moser Sivils KL, Chakravarty EF, Kamen DL, Gilkeson GS, Wallace DJ, Weisman MH, Scofield RH, Harley JB, James JA. Multiple autoantibodies display association with lymphopenia, proteinuria, and cellular casts in a large, ethnically diverse SLE patient cohort. Autoimmune Dis 2012:819634, 2012. [Abstract]

Maiti AK. Genetic determinants of oxidative stress-mediated sensitization of drug resistant cancer cells. Int J Cancer 130:1-9, 2012.[Abstract]

Manjarrez-Orduño N, Marasco E, Chung SA, Katz MS, Kiridly JF, Simpfendorfer KR, Freudenberg J, Ballard DH, Nashi E, Hopkins TJ, Cunninghame Graham DS, Lee AT, Coenen MJ, Franke B, Swinkels DW, Graham RR, Kimberly RP, Gaffney PM, Vyse TJ, Behrens TW, Criswell LA, Diamond B, Gregersen PK. CSK regulatory polymorphism is associated with systemic lupus erythematosus and influences B-cell signaling and activation. Nat Genet 44:1227-1230, 2012.[Abstract]

Morris DL, Taylor KE, Fernando MM, Nititham J, Alarcón-Riquelme ME, Barcellos LF, Behrens TW, Cotsapas C, Gaffney PM, Graham RR, Pons-Estel BA, Gregersen PK, Harley JB, Hauser SL, Hom G, International MHC and Autoimmunity Genetics Network, Langefeld CD, Noble JA, Rioux JD, Seldin MF, Systemic Lupus Erythematosus Genetics Consortium, Criswell LA, Vyse TJ. Unraveling multiple MHC gene associations with systemic lupus erythematosus: model choice indicates a role for HLA alleles and non-HLA genes in Europeans. Am J Hum Genet 91:778-793,2012. [Abstract]

* Namjou B, Choi CB, Harley IT, Alarcón-Riquelme ME, on behalf of BIOLUPUS, Kelly JA, Glenn SB, Ojwang JO, Adler A, Kim K, Gallant CJ, Boackle SA, Criswell LA, Kimberly RP, Brown EE, Edberg J, Alarcón GS, Stevens AM, Jacob CO, Gilkeson GS, Kamen DL, Tsao BP, Anaya JM, Kim EM, Park SY, Sung YK, Guthridge JM, Merrill JT, Petri M, Ramsey-Goldman R, Vilá LM, Niewold TB, Martin J, Pons-Estel BA, Genoma en Lupus Network, Vyse TJ, Freedman BI, Moser KL, Gaffney PM, Williams AH, Comeau ME, Reveille JD, Kang C, James JA, Scofield RH, Langefeld CD, Kaufman KM, Harley JB, Bae SC. Evaluation of TRAF6 in a large multiancestral lupus cohort. Arthritis Rheum 64:1960-1969, 2012. [Abstract]

Namjou B, Keddache M, Fletcher D, Dillon S, Kottyan L, Wiley G, Gaffney P, Wakeland B, Liang C, Wakeland E, Scofield R, Kaufman K, Harley J. Identification of novel coding mutation in C1qA gene in an African-American pedigree with lupus and C1q deficiency. Lupus 21:1113-1118, 2012. [Abstract]

* Niewold TB, Kelly JA, Kariuki SN, Franek BS, Kumar AA, Kaufman KM, Thomas K, Walker D, Kamp S, Frost JM, Wong AK, Merrill JT, Alarcon-Riquelme ME, Tikly M, Ramsey-Goldman R, Reveille JD, Petri MA, Edberg JC, Kimberly RP, Alarcon GS, Kamen DL, Gilkeson GS, Vyse TJ, James JA, Gaffney PM, Moser KL, Crow MK, Harley JB. IRF5 haplotypes demonstrate diverse serological associations which predict serum interferon alpha activity and explain the majority of the genetic association with systemic lupus erythematosus. Ann Rheum Dis 71:463-469, 2012. [Abstract]

Peng H, Bateman A, Valencia A, Wren JD. Bioimage informatics: a new category in bioinformatics. Bioinformatics 28:1057, 2012. [Abstract]

* Popova L, Smith K, West AH, Wilson PC, James JA, Thompson LF, Air GM. Immunodominance of antigenic Site B over Site A of Hemagglutinin of recent H3N2 influenza viruses. PLoS One 7:e41895, 2012. [Abstract]

Radhakrishna U, Nath SK, McElreavey K, Ratnamala U, Sun C, Maiti AK, Gagnebin M, Bena F, Newkirk HL, Sharp AJ, Everman DB, Murray JC, Schwartz CE, Antonarakis SE, Butler MG. Genome-wide linkage and copy number variation analysis reveals 710 kb duplication on chromosome 1p31.3 responsible for autosomal dominant omphalocele. J Med Genet 49:270-276, 2012. [Abstract]

Radhakrishna U, Ratnamala U, Deutsch S, Bartoloni L, Kuracha MR, Singh R, Banwait J, Bastola DK, Johar K, Nath SK, Antonarakis SE. Novel homozygous, heterozygous and hemizygous FRMD7 gene mutations segregated in the same consanguineous family with congenital X-linked nystagmus. Eur J Hum Genet 20:1032-1036, 2012.. [Abstract]

Sahoo K, Dozmorov MG, Anant S, Awasthi V. The curcuminoid CLEFMA selectively induces cell death in H441 lung adenocarcinoma cells via oxidative stress. Invest New Drugs 30:558-567, 2012. [Abstract]

Sánchez E, García-Bermúdez M, Jiménez-Alonso J, de Ramón E., Sánchez-Román J, Ortego-Centeno N, Witte T, D’Alfonso S, Pons-Estel B, Anders HJ, Alarcón-Riquelme ME, Martin J. Association study of IRAK-M and SIGIRR genes with SLE in a large European-descent population. Lupus 21:1166-1171, 2012. [Abstract]

* Sánchez E, Rasmussen A, Riba L, Acevedo-Vasquez E, Kelly JA, Langefeld CD, Williams AH, Ziegler JT, Comeau ME, Marion MC, García-De La Torre I, Maradiaga-Ceceña MA, Cardiel MH, Esquivel-Valerio JA, Rodriguez-Amado J, Moctezuma JF, Miranda P, Perandones CE, Castel C, Laborde HA, Alba P, Musuruana JL, Goecke IA, Anaya JM, Kaufman KM, Adler A, Glenn SB, Brown EE, Alarcón GS, Kimberly RP, Edberg JC, Vilá LM, Criswell LA, Gilkeson GS, Niewold TB, Martín J, Vyse TJ, Boackle SA, Ramsey-Goldman R, Scofield RH, Petri M, Merrill JT, Reveille JD, Tsao BP, Orozco L, Baca V, Moser KL, Gaffney PM, James JA, Harley JB, Tusié-Luna T, Pons-Estel BA, Jacob CO, Alarcón-Riquelme ME. Impact of genetic ancestry and sociodemographic status on the clinical expression of systemic lupus erythematosus in American Indian-European populations. Arthritis Rheum 64:3687-3694, 2012.[Abstract]

* Sawalha AH, Wang L, Nadig A, Somers EC, McCune WJ, the Michigan Lupus Consortium, Hughes T, Merrill JT, Scofield RH, Strickland FM, Richardson B. Sex-specific differences in the relationship between genetic susceptibility, T cell DNA demethylation and lupus flare severity. J Autoimmun 38:J216-J222,2012. [Abstract]

Scofield AK, Radfar L, Ice JA, Vista E, Anaya JM, Houston G, Lewis D, Stone DU, Chodosh J, Hefner K, Lessard CJ, Moser KL, Scofield RH. Relation of sensory peripheral neuropathy in Sjogren syndrome to Anti-Ro/SSA. J Clin Rheumatol 18:290-293, 2012. [Abstract]

Scofield RH, Sestak AL. Juvenile spondyloarthropathies. Curr Rheumatol Rep 14:395-401, 2012. [Abstract]

Segal BM, Pogatchnik B, Holker E, Liu H, Sloan J, Rhodus N, Moser KL. Primary Sjogren’s syndrome: cognitive symptoms, mood, and cognitive performance. Acta Neurol Scand 125:272-278, 2012. [Abstract]

Smith K, Crowe SR, Garman L, Guthridge C, Muther JJ, McKee E, Farris AD, Guthridge JM, Wilson PC, James JA. Human monoclonal antibodies generated following vaccination with AVA provide neutralization by blocking furin cleavage but not by preventing oligomerization. Vaccine 30:4276-4283, 2012. [Abstract]

Strickland FM, Hewagama A, Lu Q, Wu A, Hinderer R, Webb R, Johnson K, Sawalha AH, Delaney C, Yung R, Richardson BC. Environmental exposure, estrogen and two X chromosomes are required for disease development in an epigenetic model of lupus. J Autoimmun 38:J135-J143,2012. [Abstract]

* Sun D, Raisley B, Langer M, Iyer JK, Vedham V, Ballard JL, James JA, Metcalf J, Coggeshall KM. Anti-peptidoglycan antibodies and Fcgamma receptors are the key mediators of inflammation in gram-positive sepsis. J Immunol 189:2423-2431, 2012. [Abstract]

Teruel M, Martin JE, Ortego-Centeno N, Jiménez-Alonso J, Sánchez-Román J, de Ramón E., Gonzalez-Escribano MF, Pons-Estel BA, D’Alfonso S, Sebastiani GD, Witte T, Bottini N, González-Gay MA, Alarcón-Riquelme ME, Martin J. Novel association of acid phosphatase locus 1*C allele with systemic lupus erythematosus. Hum Immunol 73:107-110, 2012. [Abstract]

* Vista E, Crowe S, Thompson L, Air G, Robertson J, Guthridge J, James J. Influenza vaccination can induce new-onset anticardiolipins but not beta2-glycoprotein-I antibodies among patients with systemic lupus erythematosus. Lupus 21:168-174, 2012. [Abstract]

*Wang S, Adrianto I, Wiley GB, Lessard CJ, Kelly JA, Adler AJ, Glenn SB, Williams AH, Ziegler JT, Comeau ME, Marion MC, Wakeland BE, Liang C, Kaufman KM, Guthridge JM, Alarcón-Riquelme ME, on behalf of the BIOLUPUS and GENLES Networks, Alarcon GS, Anaya JM, Bae SC, Kim JH, Joo YB, Boackle SA, Brown EE, Petri MA, Ramsey-Goldman R, Reveille JD, Vila LM, Criswell LA, Edberg JC, Freedman BI, Gilkeson GS, Jacob CO, James JA, Kamen DL, Kimberly RP, Martin J, Merrill JT, Niewold TB, Pons-Estel BA, Scofield RH, Stevens AM, Tsao BP, Vyse TJ, Langefeld CD, Harley JB, Wakeland EK, Moser KL, Montgomery CG, Gaffney PM. A functional haplotype of UBE2L3 confers risk for systemic lupus erythematosus. Genes Immun 13:380-387, 2012. [Abstract]

Weckerle CE, Mangale D, Franek BS, Kelly JA, Kumabe M, James JA, Moser KL, Harley JB, Niewold TB. Large-scale analysis of tumor necrosis factor alpha levels in systemic lupus erythematosus. Arthritis Rheum 64:2947-292, 2012. [Abstract]

Yan X, Li F, Dozmorov I, Frank MB, Dao M, Centola M, Cao W, Hu D. External Qi of Yan Xin Qigong induces cell death and gene expression alterations promoting apoptosis and inhibiting proliferation, migration and glucose metabolism in small-cell lung cancer cells. Mol Cell Biochem 363:245-255, 2012. [Abstract]

Zhou XJ, Lu XL, Nath SK, Lv JC, Zhu SN, Yang HZ, Qin LX, Zhao MH, Su Y, The International Consortium for Systemic Lupus Erythematosus Genetics (SLEGEN), Shen N, Li ZG, Zhang H. Gene-gene interaction of BLK, TNFSF4, TRAF1, TNFAIP3, REL in systemic lupus erythematosus. Arthritis Rheum 64:222-231,2012. [Abstract]

Cardiovascular Biology Research Program

Ahmed I, Chandrakesan P, Tawfik O, Xia L, Anant S, Umar S. Critical roles of Notch and Wnt/beta-catenin pathways in the regulation of hyperplasia and/or colitis in response to bacterial infection. Infect Immun 80:3107-3121, 2012. [Abstract]

Chichili GR, Cail RC, Rodgers W. Cytoskeletal modulation of lipid interactions regulates Lck kinase activity. J Biol Chem 287:24186-24194, 2012. [Abstract]

Curtis CD, Davis RB, Ingram KG, Griffin CT. Chromatin-remodeling complex specificity and embryonic vascular development. Cell Mol Life Sci 69:3921-3931,2012. [Abstract]

Curtis CD, Griffin CT. The chromatin-remodeling enzymes BRG1 and CHD4 antagonistically regulate vascular Wnt signaling. Mol Cell Biol 32:1312-1320, 2012. [Abstract]

Ji W, Li Y, Wan T, Wang J, Zhang H, Chen H, Min W. Both internalization and AIP1 association are required for tumor necrosis factor receptor 2-mediated JNK signaling. Arterioscler Thromb Vasc Biol 32:2271-2279, 2012. [Abstract]

Jones D, Li Y, He Y, Xu Z, Chen H, Min W. Mirtron microRNA-1236 inhibits VEGFR-3 signaling during inflammatory lymphangiogenesis. Arterioscler Thromb Vasc Biol 32:633-642, 2012. [Abstract]

Kanan Y, Hamilton RA, Moore KL, Al-Ubaidi MR. Protein tyrosine-o-sulfation in bovine ocular tissues. Adv Exp Med Biol 723:835-841, 2012. [Abstract]

Kim PY, Kim PY, Taylor FB, Jr., Nesheim ME. Thrombin-activatable fibrinolysis inhibitor is activated in vivo in a baboon model of Escherichia coli induced sepsis. J Thromb Thrombolysis 33:412-415, 2012. [Abstract]

* Langer M, Duggan ES, Booth JL, Patel VI, Zander RA, Silasi-Mansat R, Ramani V, Veres TZ, Prenzler F, Sewald K, Williams DM, Coggeshall KM, Awasthi S, Lupu F, Burian D, Ballard JD, Braun A, Metcalf JP. Bacillus anthracis lethal toxin reduces human alveolar epithelial barrier function. Infect Immun 80:4374-4387,2012. [Abstract]

* Pasula S, Cai X, Dong Y, Messa M, McManus J, Chang B, Liu X, Zhu H, Mansat RS, Yoon SJ, Hahn S, Keeling J, Saunders D, Ko G, Knight J, Newton G, Luscinskas F, Sun X, Towner R, Lupu F, Xia L, Cremona O, De Camilli P, Min W, Chen H. Endothelial epsin deficiency decreases tumor growth by enhancing VEGF signaling. J Clin Invest  122:4424-4438, 2012. [Abstract]

Shao B, Yago T, Coghill PA, Klopocki AG, Mehta-D’Souza P, Schmidtke DW, Rodgers W, McEver RP. Signal-dependent slow leukocyte rolling does not require cytoskeletal anchorage of P-selectin glycoprotein ligand-1 (PSGL-1) or integrin alphaLbeta2. J Biol Chem 287:19585-19598,2012. [Abstract]

Sherry DM, Kanan Y, Hamilton R, Hoffhines A, Arbogast KL, Fliesler SJ, Naash MI, Moore KL, Al-Ubaidi MR. Differential developmental deficits in retinal function in the absence of either protein Tyrosine Sulfotransferase-1 or -2. PLoS One 7:e39702, 2012. [Abstract]

Taylor FB, Jr., Kinasewitz GT, Lupu F. Pathophysiology, staging and therapy of severe sepsis in baboon models. J Cell Mol Med 16:672-682, 2012. [Abstract]

Thomsson KA, Holmen-Larsson JM, Angstrom J, Johansson ME, Xia L, Hansson GC. Detailed O-glycomics of the Muc2 mucin from colon of wild-type, Core 1- and Core 3-transferase-deficient mice highlights differences compared with human MUC2. Glycobiology 22:1128-1139, 2012. [Abstract]

* Towner RA, Smith N, Saunders D, Henderson M, Downum K, Lupu F, Silasi-Mansat R, Ramirez DC, Gomez-Mejiba SE, Bonini MG, Ehrenshaft M, Mason RP. In vivo imaging of immunospin-trapped radicals with molecular magnetic resonance imaging in a mouse diabetes model. Diabetes 61:2405-2413, 2012. [Abstract]

Van Hul M, Lupu F, Dresselaers T, Buyse J, Lijnen HR. Matrix metalloproteinase inhibition affects adipose tissue mass in obese mice. Clin Exp Pharmacol Physiol 39:544-550, 2012. [Abstract]

Wang S, Zhang C, Zhang M, Liang B, Zhu H, Lee J, Viollet B, Xia L, Zhang Y, Zou MH. Activation of AMP-activated protein kinase alpha2 by nicotine instigates formation of abdominal aortic aneurysms in mice in vivo. Nat Med 18:902-910, 2012. [Abstract]

Xiao B, Tong C, Jia X, Guo R, Lu S, Zhang Y, McEver RP, Zhu C, Long M. Tyrosine replacement of PSGL-1 reduces association kinetics with P- and L-Selectin on the cell membrane. Biophys J 103:777-785, 2012. [Abstract]

Yao L, Heuser-Baker J, Herlea-Pana O, Iida R, Wang Q, Zou MH, Barlic-Dicen J. Bone marrow endothelial progenitors augment atherosclerotic plaque regression in a mouse model of plasma lipid lowering. Stem Cells 30:2720-2731,2012. [Abstract]

Zhai Z, Gomez-Mejiba SE, Zhu H, Lupu F, Ramirez DC. The spin trap 5,5-dimethyl-1-pyrroline N-oxide inhibits lipopolysaccharide-induced inflammatory response in RAW 264.7 cells. Life Sci 90:432-439, 2012. [Abstract]

Cell Cycle and Cancer Biology Research Program

Bisig CG, Guiraldelli MF, Kouznetsova A, Scherthan H, Hoog C, Dawson DS, Pezza RJ. Synaptonemal complex components persist at centromeres and are required for homologous centromere pairing in mouse spermatocytes. PLoS Genet 8:e1002701, 2012. [Abstract]

Lee CY, Conrad MN, Dresser ME. Meiotic chromosome pairing is promoted by telomere-led chromosome movements independent of bouquet formation. PLoS Genet 8:e1002730, 2012. [16 pages]

Liu H, Rankin S, Yu H. Phosphorylation-enabled binding of SGO1-PP2A to cohesin protects sororin and centromeric cohesion during mitosis. Nat Cell Biol 15:40-49, 2012. [Abstract]

Song J, Lafont A, Chen J, Wu FM, Shirahige K, Rankin S. Cohesin acetylation promotes sister chromatid cohesion only in association with the replication machinery. J Biol Chem 287:34325-34336,2012. [Abstract]

Wang F, Ulyanova NP, Daum JR, Patnaik D, Kateneva AV, Gorbsky GJ, Higgins JM. Haspin inhibitors reveal centromeric functions of Aurora B in chromosome segregation. J Cell Biol 199:251-268, 2012. [Abstract]

Clinical Pharmacology Research Program

* Adrianto I, Wang S, Wiley GB, Lessard CJ, Kelly JA, Adler AJ, Glenn SB, Williams AH, Ziegler JT, Comeau ME, Marion MC, Wakeland BE, Liang C, Kaufman KM, Guthridge JM, Alarcón-Riquelme ME, BIOLUPUS and GENLES Networks, Alarcón GS, Anaya JM, Bae SC, Kim JH, Joo YB, Boackle SA, Brown EE, Petri MA, Ramsey-Goldman R, Reveille JD, Vila LM, Criswell LA, Edberg JC, Freedman BI, Gilkeson GS, Jacob CO, James JA, Kamen DL, Kimberly RP, Martin J, Merrill JT, Niewold TB, Pons-Estel BA, Scofield RH, Stevens AM, Tsao BP, Vyse TJ, Langefeld CD, Harley JB, Wakeland EK, Moser KL, Montgomery CG, Gaffney PM. Association of two independent functional risk haplotypes in TNIP1 with systemic lupus erythematosus. Arthritis Rheum 64:3695-3705, 2012. [Abstract]

* Castillejo-López C, Delgado-Vega AM, Wojcik J, Kozyrev SV, Thavathiru E, Wu YY, Sanchez E, Pöllmann D, Lopez-Egido JR, Fineschi S, Dominguez N, Lu R, James JA, Merrill JT, Kelly JA, Kaufman KM, Moser KL, Gilkeson G, Frostegård J, Pons-Estel BA, D’Alfonso S, Witte T, Callejas JL, Harley JB, Gaffney PM, Martin J, Guthridge JM, Alarcón-Riquelme ME. Genetic and physical interaction of the B-cell systemic lupus erythematosus-associated genes BANK1 and BLK. Ann Rheum Dis 71:136-142, 2012. [Abstract]

Hahn BH, McMahon MA, Wilkinson A, Wallace WD, Daikh DI, Fitzgerald JD, Karpouzas GA, Merrill JT, Wallace DJ, Yazdany J, Ramsey-Goldman R, Singh K, Khalighi M, Choi SI, Gogia M, Kafaja S, Kamgar M, Lau C, Martin WJ, Parikh S, Peng J, Rastogi A, Chen W, Grossman JM. American College of Rheumatology guidelines for screening, treatment, and management of lupus nephritis. Arthritis Care Res (Hoboken ) 64:797-808, 2012. [Abstract]

Hanly JG, Urowitz MB, Su L, Gordon C, Bae SC, Sanchez-Guerrero J, Romero-Diaz J, Wallace DJ, Clarke AE, Ginzler E, Merrill JT, Isenberg DA, Rahman A, Petri M, Fortin PR, Gladman D, Bruce IN, Steinsson K, Dooley M, Khamashta MA, Alarcon GS, Fessler BJ, Ramsey-Goldman R, Manzi S, Zoma AA, Sturfelt GK, Nived O, Aranow C, Mackay M, Ramos-Casals M, van Vollenhoven R, Kalunian KC, Ruiz-Irastorza G, Lim S, Kamen DL, Peschken CA, Inanc M, Theriault C, Thompson K, Farewell V. Seizure disorders in systemic lupus erythematosus results from an international, prospective, inception cohort study. Ann Rheum Dis 71:1502-1509, 2012. [Abstract]

* Hughes T, Adler A, Kelly JA, Kaufman KM, Williams A, Langefeld CD, Brown EE, Alarcon GS, Kimberly RP, Edberg JC, Ramsey-Goldman R, Petri M, Boackle SA, Stevens AM, Reveille JD, Sanchez E, Martin J, Niewold TB, Vila LM, Scofield RH, Gilkeson GS, Gaffney PM, Criswell LA, Moser KL, Merrill JT, Jacob CO, Tsao BP, James JA, Vyse TJ, Alarcon-Riquelme ME, on behalf of the BIOLUPUS network, Harley JB, Richardson BC, Sawalha AH. Evidence for gene-gene epistatic interactions among susceptibility loci for systemic lupus erythematosus. Arthritis Rheum 64:485-492,2012. [Abstract]

* Hughes T, Adler A, Merrill JT, Kelly JA, Kaufman KM, Williams A, Langefeld CD, Gilkeson GS, Sanchez E, Martin J, Boackle SA, Stevens AM, Alarcon GS, Niewold TB, Brown EE, Kimberly RP, Edberg JC, Ramsey-Goldman R, Petri M, Reveille JD, Criswell LA, Vila LM, Jacob CO, Gaffney PM, Moser KL, Vyse TJ, Alarcon-Riquelme ME, BIOLUPUS N, James JA, Tsao BP, Scofield RH, Harley JB, Richardson BC, Sawalha AH. Analysis of autosomal genes reveals gene-sex interactions and higher total genetic risk in men with systemic lupus erythematosus. Ann Rheum Dis 71:694-699, 2012. [Abstract]

* Izmirly PM, Shvartsbeyn M, Meehan S, Franks A, Braun A, Ginzler E, Xu SX, Yee H, Rivera T, Esmon C, Barisoni L, Merrill JT, Buyon JP, Clancy RM. Dysregulation of the microvasculature in nonlesional non-sun-exposed skin of patients with lupus nephritis. J Rheumatol 39:510-515, 2012. [Abstract]

Jolly M, Pickard AS, Block JA, Kumar RB, Mikolaitis RA, Wilke CT, Rodby RA, Fogg L, Sequeira W, Utset TO, Cash TF, Moldovan I, Katsaros E, Nicassio P, Ishimori ML, Kosinsky M, Merrill JT, Weisman MH, Wallace DJ. Disease-specific patient reported outcome tools for systemic lupus erythematosus. Semin Arthritis Rheum 42:56-65, 2012. [Abstract]

Khanna D, Fitzgerald JD, Khanna PP, Bae S, Singh MK, Neogi T, Pillinger MH, Merrill J, Lee S, Prakash S, Kaldas M, Gogia M, Perez-Ruiz F, Taylor W, Liote F, Choi H, Singh JA, Dalbeth N, Kaplan S, Niyyar V, Jones D, Yarows SA, Roessler B, Kerr G, King C, Levy G, Furst DE, Edwards NL, Mandell B, Schumacher HR, Robbins M, Wenger N, Terkeltaub R. 2012 American College of Rheumatology guidelines for management of gout. Part 1: Systematic nonpharmacologic and pharmacologic therapeutic approaches to hyperuricemia. Arthritis Care Res (Hoboken ) 64:1431-1446, 2012. [Abstract]

Khanna D, Khanna PP, Fitzgerald JD, Singh MK, Bae S, Neogi T, Pillinger MH, Merrill J, Lee S, Prakash S, Kaldas M, Gogia M, Perez-Ruiz F, Taylor W, Liote F, Choi H, Singh JA, Dalbeth N, Kaplan S, Niyyar V, Jones D, Yarows SA, Roessler B, Kerr G, King C, Levy G, Furst DE, Edwards NL, Mandell B, Schumacher HR, Robbins M, Wenger N, Terkeltaub R. 2012 American College of Rheumatology guidelines for management of gout. Part 2: Therapy and antiinflammatory prophylaxis of acute gouty arthritis. Arthritis Care Res (Hoboken ) 64:1447-1461, 2012. [Abstract]

* Kim K, Brown EE, Choi CB, Alarcon-Riquelme ME, on behalf of BIOLUPUS, Kelly JA, Glenn SB, Ojwang JO, Adler A, Lee HS, Boackle SA, Criswell LA, Alarcon GS, Edberg JC, Stevens AM, Jacob CO, Gilkeson GS, Kamen DL, Tsao BP, Anaya JM, Guthridge JM, Nath SK, Richardson B, Sawalha AH, Kang YM, Shim SC, Suh CH, Lee SK, Kim CS, Merrill JT, Petri M, Ramsey-Goldman R, Vila LM, Niewold TB, Martin J, Pons-Estel BA, on behalf of GENLES, Vyse TJ, Freedman BI, Moser KL, Gaffney PM, Williams A, Comeau M, Reveille JD, James JA, Scofield RH, Langefeld CD, Kaufman KM, Harley JB, Kang C, Kimberly RP, Bae SC. Variation in the ICAM1-ICAM4-ICAM5 locus is associated with systemic lupus erythematosus susceptibility in multiple ancestries. Ann Rheum Dis 71:1809-1814,2012. [Abstract]

* Lessard CJ, Adrianto I, Ice JA, Wiley GB, Kelly JA, Glenn SB, Adler AJ, Li H, Rasmussen A, Williams AH, Ziegler J, Comeau ME, Marion M, Wakeland BE, Liang C, Ramos PS, Grundahl KM, Gallant CJ, Marta E.Alarcon-Riquelme for the BIOLUPUS and GENLES Networks, Alarcon GS, Anaya JM, Bae SC, Boackle SA, Brown EE, Chang DM, Cho SK, Criswell LA, Edberg JC, Freedman BI, Gilkeson GS, Jacob CO, James JA, Kamen DL, Kimberly RP, Kim JH, Martin J, Merrill JT, Niewold TB, Park SY, Petri MA, Pons-Estel BA, Ramsey-Goldman R, Reveille JD, Scofield RH, Song YW, Stevens AM, Tsao BP, Vila LM, Vyse TJ, Yu CY, Guthridge JM, Kaufman KM, Harley JB, Wakeland EK, Langefeld CD, Gaffney PM, Montgomery CG, Moser KL. Identification of IRF8, TMEM39A, and IKZF3-ZPBP2 as susceptibility loci for systemic lupus erythematosus in a large-scale multiracial replication study. Am J Hum Genet 64:485-492, 2012. [Abstract]

* Lin CP, Adrianto I, Lessard CJ, Kelly JA, Kaufman KM, Guthridge JM, Freedman BI, Anaya JM, Alarcon-Riquelme ME, on behalf of the BIOLUPUS and GENLES Networks, Pons-Estel BA, Martin J, Glenn S, Adler A, Bae SC, Park SY, Bang SY, Song YW, Boackle SA, Brown EE, Edberg JC, Alarcon GS, Petri MA, Criswell LA, Ramsey-Goldman R, Reveille JD, Vila LM, Gilkeson GS, Kamen DL, Ziegler J, Jacob CO, Rasmussen A, James JA, Kimberly RP, Merrill JT, Niewold TB, Scofield RH, Stevens AM, Tsao BP, Vyse TJ, Langefeld CD, Moser KL, Harley JB, Gaffney PM, Montgomery CG. Role of MYH9 and APOL1 in African and non-African populations with lupus nephritis. Genes Immun 13:232-238, 2012. [Abstract]

Lockshin MD, Kim M, Laskin CA, Guerra M, Branch DW, Merrill J, Petri M, Porter TF, Sammaritano L, Stephenson MD, Buyon J, Salmon JE. Prediction of adverse pregnancy outcome by the presence of lupus anticoagulant, but not anticardiolipin antibody, in patients with antiphospholipid antibodies. Arthritis Rheum 64:2311-2318, 2012. [Abstract]

Manzi S, Sanchez-Guerrero J, Merrill JT, Furie R, Gladman D, Navarra SV, Ginzler EM, D’Cruz DP, Doria A, Cooper S, Zhong ZJ, Hough D, Freimuth W, Petri MA, on behalf of the BLISS-. Effects of Belimumab, a B lymphocyte stimulator-specific inhibitor, on disease activity across multiple organ domains in patients with systemic lupus erythematosus: combined results from two phase III trials. Ann Rheum Dis71:1833-1838,,2012. [Abstract]

Merrill JT. Treatment of systemic lupus erythematosus a 2012 update. Bull NYU Hosp Jt Dis 70:172-176, 2012. [Abstract]

Merrill JT, Ginzler EM, Wallace DJ, McKay JD, Lisse JR, Aranow C, Wellborne FR, Burnette M, Condemi J, Zhong ZJ, Pineda L, Klein J, Freimuth WW, on Behalf of the LBSL. Long-term safety profile of Belimumab plus standard therapy in patients with systemic lupus erythematosus. Arthritis Rheum 64:3364-3373, 2012. [Abstract]

* Namjou B, Choi CB, Harley IT, Alarcón-Riquelme ME, on behalf of BIOLUPUS, Kelly JA, Glenn SB, Ojwang JO, Adler A, Kim K, Gallant CJ, Boackle SA, Criswell LA, Kimberly RP, Brown EE, Edberg J, Alarcón GS, Stevens AM, Jacob CO, Gilkeson GS, Kamen DL, Tsao BP, Anaya JM, Kim EM, Park SY, Sung YK, Guthridge JM, Merrill JT, Petri M, Ramsey-Goldman R, Vilá LM, Niewold TB, Martin J, Pons-Estel BA, Genoma en Lupus Network, Vyse TJ, Freedman BI, Moser KL, Gaffney PM, Williams AH, Comeau ME, Reveille JD, Kang C, James JA, Scofield RH, Langefeld CD, Kaufman KM, Harley JB, Bae SC. Evaluation of TRAF6 in a large multiancestral lupus cohort. Arthritis Rheum 64:1960-1969, 2012. [Abstract]

* Niewold TB, Kelly JA, Kariuki SN, Franek BS, Kumar AA, Kaufman KM, Thomas K, Walker D, Kamp S, Frost JM, Wong AK, Merrill JT, Alarcon-Riquelme ME, Tikly M, Ramsey-Goldman R, Reveille JD, Petri MA, Edberg JC, Kimberly RP, Alarcon GS, Kamen DL, Gilkeson GS, Vyse TJ, James JA, Gaffney PM, Moser KL, Crow MK, Harley JB. IRF5 haplotypes demonstrate diverse serological associations which predict serum interferon alpha activity and explain the majority of the genetic association with systemic lupus erythematosus. Ann Rheum Dis 71:463-469, 2012. [Abstract]

Petri M, Orbai AM, Alarcón GS, Gordon C, Merrill JT, Fortin PR, Bruce IN, Isenberg D, Wallace DJ, Nived O, Sturfelt G, Ramsey-Goldman R, Bae SC, Hanly JG, Sánchez-Guerrero J, Clarke A, Aranow C, Manzi S, Urowitz M, Gladman D, Kalunian K, Costner M, Werth VP, Zoma A, Bernatsky S, Ruiz-Irastorza G, Khamashta MA, Jacobsen S, Buyon JP, Maddison P, Dooley MA, Van Vollenhoven RF, Ginzler E, Stoll T, Peschken C, Jorizzo JL, Callen JP, Lim SS, Fessler BJ, Inanc M, Kamen DL, Rahman A, Steinsson K, Franks AG, Jr., Sigler L, Hameed S, Fang H, Pham N, Brey R, Weisman MH, McGwin G, Jr., Magder LS. Derivation and validation of Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus. Arthritis Rheum 64:2677-2686, 2012. [Abstract]

* Sánchez E, Rasmussen A, Riba L, Acevedo-Vasquez E, Kelly JA, Langefeld CD, Williams AH, Ziegler JT, Comeau ME, Marion MC, García-De La Torre I, Maradiaga-Ceceña MA, Cardiel MH, Esquivel-Valerio JA, Rodriguez-Amado J, Moctezuma JF, Miranda P, Perandones CE, Castel C, Laborde HA, Alba P, Musuruana JL, Goecke IA, Anaya JM, Kaufman KM, Adler A, Glenn SB, Brown EE, Alarcón GS, Kimberly RP, Edberg JC, Vilá LM, Criswell LA, Gilkeson GS, Niewold TB, Martín J, Vyse TJ, Boackle SA, Ramsey-Goldman R, Scofield RH, Petri M, Merrill JT, Reveille JD, Tsao BP, Orozco L, Baca V, Moser KL, Gaffney PM, James JA, Harley JB, Tusié-Luna T, Pons-Estel BA, Jacob CO, Alarcón-Riquelme ME. Impact of genetic ancestry and sociodemographic status on the clinical expression of systemic lupus erythematosus in American Indian-European populations. Arthritis Rheum 64:3687-3694, 2012.[Abstract]

* Sawalha AH, Wang L, Nadig A, Somers EC, McCune WJ, the Michigan Lupus Consortium, Hughes T, Merrill JT, Scofield RH, Strickland FM, Richardson B. Sex-specific differences in the relationship between genetic susceptibility, T cell DNA demethylation and lupus flare severity. J Autoimmun 38:J216-J222,2012. [Abstract]

Steinman L, Merrill JT, McInnes IB, Peakman M. Optimization of current and future therapy for autoimmune diseases. Nat Med 18:59-65, 2012. [Abstract]

Stohl W, Gomez-Reino J, Olech E, Dudler J, Fleischmann RM, Zerbini CA, Ashrafzadeh A, Grzeschik S, Bieraugel R, Green J, Francom S, Dummer W. Safety and efficacy of ocrelizumab in combination with methotrexate in MTX-naive subjects with rheumatoid arthritis: the phase III FILM trial. Ann Rheum Dis 71:1289-1296, 2012. [Abstract]

Urowitz M, Gladman D, Ibanez D, Fortin P, Bae S, Gordon C, Clarke A, Bernatsky S, Hanly J, Isenberg D, Rahman A, Sanchez-Guerrero J, Wallace D, Ginzler E, Alarcon G, Merrill J, Bruce I, Sturfelt G, Nived O, Steinsson K, Khamashta M, Petri M, Manzi S, Ramsey-Goldman R, Dooley M, van Vollenhoven R., Ramos M, Stoll T, Zoma A, Kalunian K, Aranow C. Evolution of disease burden over 5 years in a multicentre inception SLE cohort. Arthritis Care Res (Hoboken) 64:132-137, 2012. [Abstract]

*Wang S, Adrianto I, Wiley GB, Lessard CJ, Kelly JA, Adler AJ, Glenn SB, Williams AH, Ziegler JT, Comeau ME, Marion MC, Wakeland BE, Liang C, Kaufman KM, Guthridge JM, Alarcón-Riquelme ME, on behalf of the BIOLUPUS and GENLES Networks, Alarcon GS, Anaya JM, Bae SC, Kim JH, Joo YB, Boackle SA, Brown EE, Petri MA, Ramsey-Goldman R, Reveille JD, Vila LM, Criswell LA, Edberg JC, Freedman BI, Gilkeson GS, Jacob CO, James JA, Kamen DL, Kimberly RP, Martin J, Merrill JT, Niewold TB, Pons-Estel BA, Scofield RH, Stevens AM, Tsao BP, Vyse TJ, Langefeld CD, Harley JB, Wakeland EK, Moser KL, Montgomery CG, Gaffney PM. A functional haplotype of UBE2L3 confers risk for systemic lupus erythematosus. Genes Immun 13:380-387, 2012. [Abstract]

Coagulation Biology Laboratory

Carnemolla R, Patel KR, Zaitsev S, Cines DB, Esmon CT, Muzykantov VR. Quantitative analysis of thrombomodulin-mediated conversion of Protein C to APC: Translation from in vitro to in vivo. J Immunol Methods 384:21-24, 2012. [Abstract]

Clark CA, Vatsyayan R, Hedner U, Esmon CT, Pendurthi UR, Rao LV. Endothelial cell protein C receptor-mediated redistribution and tissue-level accumulation of factor VIIa. J Thromb Haemost 10:2383-2391,2012. [Abstract]

Cohen MJ, Call M, Nelson M, Calfee CS, Esmon CT, Brohi K, Pittet JF. Critical role of Activated Protein C in early coagulopathy and later organ failure, infection and death in trauma patients. Ann Surg 255:379-385,2012. [Abstract]

Condac E, Strachan H, Gutierrez-Sanchez G, Brainard B, Giese C, Heiss C, Johnson D, Azadi P, Bergmann C, Orlando R, Esmon CT, Harenberg J, Moremen K, Wang L. The C-terminal fragment of axon guidance molecule Slit3 binds heparin and neutralizes heparin`s anticoagulant activity. Glycobiology 22:1183-1192, 2012. [Abstract]

Esmon CT. Protein C anticoagulant system–anti-inflammatory effects. Semin Immunopathol 34:127-132, 2012. [Abstract]

Esmon CT. What did we learn from new oral anticoagulant treatment? Thromb Res 130S1:S41-S43, 2012. [Abstract]

Gopalakrishnan R, Pendurthi UR, Hedner U, Agerso H, Esmon CT, Rao LV. Influence of endothelial cell protein C receptor on plasma clearance of factor VIIa. J Thromb Haemost 10:971-973, 2012. [Abstract]

* Izmirly PM, Shvartsbeyn M, Meehan S, Franks A, Braun A, Ginzler E, Xu SX, Yee H, Rivera T, Esmon C, Barisoni L, Merrill JT, Buyon JP, Clancy RM. Dysregulation of the microvasculature in nonlesional non-sun-exposed skin of patients with lupus nephritis. J Rheumatol 39:510-515, 2012. [Abstract]

Kutcher ME, Xu J, Vilardi RF, Ho C, Esmon CT, Cohen MJ. Extracellular histone release in response to traumatic injury: Implications for a compensatory role of activated protein C. J Trauma Acute Care Surg 73:1387-1392, 2012. [Abstract]

Lopez-Sagaseta J, Puy C, Tamayo I, Allende M, Cervero J, Velasco SE, Esmon CT, Montes R, Hermida J. sPLA2-V inhibits EPCR anticoagulant and antiapoptotic properties by accommodating lysophosphatidylcholine or PAF in the hydrophobic groove. Blood 119:2914-2921,2012. [Abstract]

Madhusudhan T, Wang H, Straub BK, Grone E, Zhou Q, Shahzad K, Muller-Krebs S, Schwenger V, Gerlitz B, Grinnell BW, Griffin JH, Reiser J, Grone HJ, Esmon CT, Nawroth PP, Isermann B. Cytoprotective signaling by activated protein C requires protease-activated receptor-3 in podocytes. Blood 119:874-883, 2012. [Abstract]

Sen P, Clark CA, Gopalakrishnan R, Hedner U, Esmon CT, Pendurthi UR, Rao LV. Factor VIIa binding to endothelial cell protein C receptor: Differences between mouse and human systems. Thromb Haemost 107:951-961, 2012. [Abstract]

Sopel MJ, Rosin NL, Falkenham AG, Bezuhly M, Esmon CT, Lee TD, Liwski RS, Legare JF. Treatment with Activated Protein C (aPC) is protective during the development of myocardial fibrosis: an angiotensin II infusion model in mice. PLoS One 7:e45663, 2012. [Abstract]

Zaitsev S, Kowalska MA, Neyman M, Carnemolla R, Tliba S, Ding BS, Stonestrom A, Spitzer D, Atkinson JP, Poncz M, Cines DB, Esmon CT, Muzykantov VR. Targeting recombinant thrombomodulin fusion protein to red blood cells provides multifaceted thromboprophylaxis. Blood 119:4779-4785, 2012. [Abstract]

Zeerleder S, Stephan F, Emonts M, de Kleijn ED, Esmon CT, Varadi K, Hack CE, Hazelzet JA. Circulating nucleosomes and severity of illness in children suffering from meningococcal sepsis treated with protein C. Crit Care Med 40:3224-3229,2012. [Abstract]

Experimental Therapeutics Research Laboratory

Coria MJ, Viglianco YV, Marra CA, Gomez-Mejiba SE, Ramirez DC, Anzulovich AC, Gimenez MS. Hypothyroidism modifies lipid composition of polymorphonuclear leukocytes. Cell Physiol Biochem 29:713-724, 2012. [Abstract]

Du X, Chen K, Choi CH, Li W, Cheng W, Stewart C, Hu N, Floyd RA, Kopke RD. Selective degeneration of synapses in the dorsal cochlear nucleus of chinchilla following acoustic trauma and effects of antioxidant treatment. Hear Res 283:1-13, 2012. [Abstract]

Ewert DL, Lu J, Li W, Du X, Floyd R, Kopke R. Antioxidant treatment reduces blast-induced cochlear damage and hearing loss. Hear Res 285:29-39, 2012. [Abstract]

Zhai Z, Gomez-Mejiba SE, Gimenez MS, Deterding LJ, Tomer KB, Mason RP, Ashby MT, Ramirez DC. Free radical-operated proteotoxic stress in macrophages primed with lipopolysaccharide. Free Radic Biol Med 53:172-181, 2012. [Abstract]

Free Radical Biology and Aging Research Program

Aurora AB, Mahmoud AI, Luo X, Johnson BA, van Rooij E, Matsuzaki S, Humphries KM, Hill JA, Bassel-Duby R, Sadek HA, Olson EN. MicroRNA-214 protects the mouse heart from ischemic injury by controlling Ca2+ overload and cell death. J Clin Invest 122:1222-1232, 2012. [Abstract]

Ghosh SK, Yohannes E, Bebek G, Weinberg A, Jiang B, Willard B, Kinter M, Chance MR, McCormick TS. Proteomic and bioinformatic profile of primary human oral epithelial cells. J Proteome Res 11:5492-5502, 2012. [Abstract]

Griffin TM, Huebner JL, Kraus VB, Yan Z, Guilak F. Induction of osteoarthritis and metabolic inflammation by a very high fat diet in mice: Effects of short-term exercise. Arthritis Rheum 64:443-453, 2012. [Abstract]

Issa RI, Griffin TM. Pathobiology of obesity and osteoarthritis: integrating biomechanics and inflammation. Pathobiol Aging Age Relat Dis 2:17470, 2012. [7 pages]

Kinter CS, Lundie JM, Patel H, Rindler PM, Szweda LI, Kinter M. A Quantitative proteomic profile of the Nrf2-mediated antioxidant response of macrophages to oxidized LDL determined by multiplexed selected reaction monitoring. PLoS One 2012;7(11):e50016 [Abstract]

Plafker SM, O’Mealey GB, Szweda LI. Mechanisms for countering oxidative stress and damage in retinal pigment epithelium. Int Rev Cell Mol Biol 298:135-177, 2012. [Abstract]

Roach GC, Edke M, Griffin TM. A novel mouse running wheel that senses individual limb forces: Biomechanical validation and in vivo testing. J Appl Physiol 113:627-635, 2012. [Abstract]

Ziady AG, Sokolow A, Shank SL, Corey DA, Myers R, Plafker S, Kelley TJ. Interaction with CREB binding protein modulates the activities of Nrf2 and NF-kappaB in cystic fibrosis airway epithelial cells. Am J Physiol Lung Cell Mol Physiol 302:L1221-L1231, 2012. [Abstract]

Zhu X, Castellani RJ, Moreira PI, Aliev G, Shenk JC, Siedlak SL, Harris PL, Fujioka H, Sayre LM, Szweda PA, Szweda LI, Smith MA, Perry G. Hydroxynonenal-generated crosslinking fluorophore accumulation in Alzheimer disease reveals a dichotomy of protein turnover. Free Radic Biol Med 52:699-704, 2012. [Abstract]

Genetic Models of Disease

Mathews EA, Mullen GP, Hodgkin J, Duerr JS, Rand JB. Genetic Interactions between UNC-17/VAChT and a Novel Transmembrane Protein in Caenorhabditis elegans. Genetics 192:1315-1325,2012. [Abstract]

Mullen GP, Grundahl KM, Gu M, Watanabe S, Hobson RJ, Crowell JA, McManus JR, Mathews EA, Jorgensen EM, Rand JB. UNC-41/Stonin functions with AP2 to recycle synaptic vesicles in Caenorhabditis elegans. PLoS One 7:e40095, 2012. [Abstract]

Immunobiology and Cancer Research Program

Blackburn MR, Thompson LF. Adenosine deaminase deficiency: unanticipated benefits from the study of a rare immunodeficiency. J Immunol 188:933-935, 2012. [Abstract]

Greif DM, Kumar M, Lighthouse JK, Hum J, An A, Ding L, Red-Horse K, Espinoza FH, Olson L, Offermanns S, Krasnow MA. Radial construction of an arterial wall. Dev Cell 23:482-493, 2012. [Abstract]

* Ichii M, Frank MB, Iozzo RV, Kincade PW. The canonical Wnt pathway shapes niches supportive for hematopoietic stem/progenitor cells. Blood 119:1683-1692, 2012.  [Abstract]

Kincade PW. Moving the field of B lymphopoiesis (editorial). J Immunol 189:3269-3270, 2012. [Abstract]

* Langer M, Duggan ES, Booth JL, Patel VI, Zander RA, Silasi-Mansat R, Ramani V, Veres TZ, Prenzler F, Sewald K, Williams DM, Coggeshall KM, Awasthi S, Lupu F, Burian D, Ballard JD, Braun A, Metcalf JP. Bacillus anthracis lethal toxin reduces human alveolar epithelial barrier function. Infect Immun 80:4374-4387,2012. [Abstract]

Long CL, Berry WL, Zhao Y, Sun XH, Humphrey MB. E proteins regulate osteoclast maturation and survival. J Bone Miner Res 27:2476-2489,2012. [Abstract]

Luis TC, Ichii M, Brugman MH, Kincade P, Staal FJ. Wnt signaling strength regulates normal hematopoiesis and its deregulation is involved in leukemia development. Leukemia 26:414-421, 2012. [Abstract]

* Pasula S, Cai X, Dong Y, Messa M, McManus J, Chang B, Liu X, Zhu H, Mansat RS, Yoon SJ, Hahn S, Keeling J, Saunders D, Ko G, Knight J, Newton G, Luscinskas F, Sun X, Towner R, Lupu F, Xia L, Cremona O, De Camilli P., Min W, Chen H. Endothelial epsin deficiency decreases tumor growth by enhancing VEGF signaling. J Clin Invest 122:4424-4438, 2012. [Abstract]

* Popova L, Smith K, West AH, Wilson PC, James JA, Thompson LF, Air GM. Immunodominance of antigenic Site B over Site A of Hemagglutinin of recent H3N2 influenza viruses. PLoS One 7:e41895, 2012. [Abstract]

Rose K, Long P, Shankar M, Ballard JD, Webb CF. Serum amyloid A protects murine macrophages from lethal toxin-mediated death. Cell Immunol 272:175-181, 2012. [Abstract]

Shimazu T, Iida R, Zhang Q, Welner RS, Medina KL, Alberola-Ila J, Kincade PW. CD86 is expressed on murine hematopoietic stem cells and denotes lymphopoietic potential. Blood 119:4889-4897, 2012. [Abstract]

Stagg J, Thompson LF, Dwyer KM. Ectonucleotidases in cancer and inflammation. J Biomed Biotechnol 2012:951423, 2012. [Abstract]

* Sun D, Raisley B, Langer M, Iyer JK, Vedham V, Ballard JL, James JA, Metcalf J, Coggeshall KM. Anti-peptidoglycan antibodies and Fcgamma receptors are the key mediators of inflammation in gram-positive sepsis. J Immunol 189:2423-2431, 2012. [Abstract]

Sun Y, Teng I, Huo R, Rosenfeld MG, Olson LE, Li X, Li X. Asymmetric requirement of surface epithelial beta-catenin during the upper and lower jaw development. Dev Dyn 241:663-674, 2012. [Abstract]

Takedachi M, Oohara H, Smith BJ, Iyama M, Kobashi M, Maeda K, Long CL, Humphrey MB, Stoecker BJ, Toyosawa S, Thompson LF, Murakami S. CD73-generated adenosine promotes osteoblast differentiation. J Cell Physiol 227:2622-2631, 2012.    [Abstract]

Tsukamoto H, Chernogorova P, Ayata K, Gerlach UV, Rughani A, Ritchey JW, Ganesan J, Follo M, Zeiser R, Thompson LF, Idzko M. Deficiency of CD73/ecto-5′-nucleotidase in mice enhances acute graft-versus-host disease. Blood 119:4554-4564, 2012. [Abstract]

* Vista E, Crowe S, Thompson L, Air G, Robertson J, Guthridge J, James J. Influenza vaccination can induce new-onset anticardiolipins but not beta2-glycoprotein-I antibodies among patients with systemic lupus erythematosus. Lupus 21:168-174, 2012. [Abstract]

Wang HC, Peng V, Zhao Y, Sun XH. Enhanced notch activation is advantageous but not essential for T cell lymphomagenesis in Id1 transgenic mice. PLoS One 7:e32944, 2012. [Abstract]

Wu W, Sun XH. Janus kinase 3: the controller and the controlled. Acta Biochim Biophys Sin (Shanghai) 44:187-196, 2012.[Abstract]

Yusuf D, Butland SL, Swanson MI, Bolotin E, Ticoll A, Cheung WA, Zhang XY, Dickman CT, Fulton DL, Lim JS, Schnabl JM, Ramos OH, Vasseur-Cognet M, de Leeuw CN, Simpson EM, Ryffel GU, Lam EW, Kist R, Wilson MS, Marco-Ferreres R, Brosens JJ, Beccari LL, Bovolenta P, Benayoun BA, Monteiro LJ, Schwenen HD, Grontved L, Wederell E, Mandrup S, Veitia RA, Chakravarthy H, Hoodless PA, Mancarelli M, Torbett BE, Banham AH, Reddy SP, Cullum RL, Liedtke M, Tschan MP, Vaz M, Rizzino A, Zannini M, Frietze S, Farnham PJ, Eijkelenboom A, Brown PJ, Laperriere D, Leprince D, de CT, Prince KL, Putker M, Del PL, Camenisch G, Wenger RH, Mikula M, Rozendaal M, Mader S, Ostrowski J, Rhodes SJ, Van RC, Boulay G, Olechnowicz SW, Breslin MB, Lan MS, Nanan KK, Wegner M, Hou J, Mullen RD, Colvin SC, Noy PJ, Webb CF, Witek ME, Ferrell S, Daniel JM, Park J, Waldman SA, Peet DJ, Taggart M, Jayaraman PS, Karrich JJ, Blom B, Vesuna F, O’Geen H, Sun Y, Gronostajski RM, Woodcroft MW, Hough MR, Chen E, Europe-Finner N, Karolczak-Bayatti M, Bailey J, Hankinson O, Raman V, Lebrun DP, Biswal S, Harvey CJ, Debruyne JP, Hogenesch JB, Hevner RF, Heligon C, Luo XM, Blank MC, Millen KJ, Sharlin DS, Forrest D, Dahlman-Wright K, Zhao C, Mishima Y, Sinha S, Chakrabarti R, Portales-Casamar E, Sladek FM, Bradley PH, Wasserman WW. The Transcription Factor Encyclopedia. Genome Biol 13:R24, 2012. [Abstract]

Zhang Q, Iida R, Shimazu T, Kincade PW. Replenishing B lymphocytes in health and disease. Curr Opin Immunol 24:196-203, 2012. [Abstract]

Lipid and Lipoprotein Laboratory

Bagdade JD, Knight-Gibson C, Simpson N, Gerkin R, Alaupovic P, Reardon C. CETP-mediated cholesteryl ester enrichment of apoB subclasses in type 1 diabetes. Eur J Clin Invest 42:709-716, 2012. [Abstract]

Basu A, Alaupovic P, Wu M, Jenkins AJ, Yu Y, Nankervis AJ, Hanssen KF, Scholz H, Henriksen T, Lorentzen B, Clausen T, Garg SK, Menard MK, Hammad SM, Scardo JA, Stanley JR, Dashti A, Aston CE, Lyons TJ. Plasma lipoproteins and preeclampsia in women with Type 1 diabetes: a prospective study. J Clin Endocrinol Metab 97:1752-1762, 2012. [Abstract]

Blackett PR, Khan S, Wang W, Alaupovic P, Lee E.  Sex differences in HDL ApoC-III in American Indian youth. Biol Sex Differ 3:18, 2012. [Abstract]

* Knowlton N, Wages J, Centola M, Alaupovic P. Apolipoprotein-defined lipoprotein abnormalities in rheumatoid arthritis patients and their potential impact on cardiovascular disease. Scand J Rheumatol 41:165-169,  2012. [Abstract]

* Knowlton N, Wages JA, Centola MB, Giles J, Bathon J, Quiroga C, Alaupovic P. Apolipoprotein B-containing lipoprotein subclasses as risk factors for cardiovascular disease in patients with rheumatoid arthritis. Arthritis Care Res (Hoboken) 64:993-1000, 2012. [Abstract]

Roussell MA, Hill AM, Gaugler TL, West SG, Vanden Heuvel JP, Alaupovic P, Gillies PJ, Kris-Etherton PM. Beef in an Optimal Lean Diet study: effects on lipids, lipoproteins, and apolipoproteins. Am J Clin Nutr 95:9-16, 2012. [Abstract]

Protein Studies Research Program

Ghosh AK, Brindisi M, Tang J. Developing ß-secretase inhibitors for treatment of Alzheimer’s disease. J Neurochem 120 Suppl 1:71-83, 2012. [Abstract]

Ghosh AK, Pandey S, Gangarajula S, Kulkarni S, Xu X, Rao KV, Huang X, Tang J. Structure-based design, synthesis, and biological evaluation of dihydroquinazoline-derived potent beta-secretase inhibitors. Bioorg Med Chem Lett 22(17):5460-5465, 2012. [Abstract]

Ghosh AK, Venkateswara RK, Yadav ND, Anderson DD, Gavande N, Huang X, Terzyan S, Tang J. Structure-based design of highly selective beta-secretase inhibitors: synthesis, biological evaluation, and protein-ligand X-ray crystal structure. J Med Chem 55:9195-9207,2012. [Abstract]

Li F, Chvyrkova I, Terzyan S, Wakeham N, Turner R, Ghosh AK, Zhang XC, Tang J. Inhibition of anthrax lethal factor: lability of hydroxamate as a chelating group. Appl Microbiol Biotechnol 94:1041-1049, 2012. [Abstract]

* Indicates publications by more than one department.

 

 

* Indicates publications by more than one department.

 

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