2011 Scientific Publications

OMRF Publications for 2011

Advanced Magnetic Resonance Center

* Floyd RA, Chandru HK, He T, Towner R. Anti-cancer activity of nitrones and observations on mechanism of action. Anticancer Agents Med Chem 11:373-379, 2011. [Abstract]

* Floyd RA, Towner RA, He T, Hensley K, Maples KR. Translational research involving oxidative stress and diseases of aging. Free Radic Biol Med 51:931-941, 2011. [Abstract]

* He T, Doblas S, Saunders D, Casteel R, Lerner M, Ritchey JW, Snider T, Floyd RA, Towner RA. Effects of PBN and OKN007 in rodent glioma models assessed by (1)H MR spectroscopy. Free Radic Biol Med 51:490-502,2011. [Abstract]

* He T, Smith N, Saunders D, Doblas S, Watanabe Y, Hoyle J, Silasi-Mansat R, Lupu F, Lerner M, Brackett DJ, Towner RA.  Molecular MRI assessment of vascular endothelial growth factor receptor-2 in rat C6 gliomas. J Cell Mol Med 15:837-849, 2011. [Abstract]

Le K, Li X, Figueroa D, Towner RA, Garteiser P, Saunders D, Smith N, Liu H, Hode T, Nordquist RE, Chen WR. Assessment of thermal effects of interstitial laser phototherapy on mammary tumors using proton resonance frequency method. J Biomed Opt 16:128001, 2011. [Abstract]

Niu C, Smith N, Garteiser P, Towner R, Verchot J. Comparative analysis of protein transport in the N. benthamiana vasculature reveals different destinations. Plant Signal Behav 6:1793-1808, 2011. [Abstract]

Arthritis and  Clinical Immunology Research Program

* Adrianto I, Wen F, Templeton A, Wiley G, King JB, Lessard CJ, Bates JS, Hu Y, Kelly JA, Kaufman KM, Guthridge JM, Alarcón-Riquelme ME, Anaya JM, Bae SC, Bang SY, Boackle SA, Brown EE, Petri MA, Gallant C, Ramsey-Goldman R, Reveille JD, Vila LM, Criswell LA, Edberg JC, Freedman BI, Gregersen PK, Gilkeson GS, Jacob CO, James JA, Kamen DL, Kimberly RP, Martin J, Merrill JT, Niewold TB, Park SY, Pons-Estel BA, Scofield RH, Stevens AM, Tsao BP, Vyse TJ, Langefeld CD, Harley JB, Moser KL, Webb CF, Humphrey MB, Montgomery CG, Gaffney PM. Association of a functional variant downstream of TNFAIP3 with systemic lupus erythematosus. Nat Genet 43:253-258, 2011.[ Abstract]

* Air GM, Feng J, Chen T, Joachims ML, James JA, Thompson LF. Individual antibody and T cell responses to vaccination and infection with the 2009 pandemic swine-origin H1N1 influenza virus. J Clin Immunol 31:900-912, 2011.[Abstract]

Bippes CC, Feldmann A, Stamova S, Cartellieri M, Schwarzer A, Wehner R, Schmitz M, Rieber EP, Zhao S, Schakel K, Temme A, Scofield RH, Kurien BT, Bartsch H, Bachmann M. A novel modular antigen delivery system for immuno targeting of human 6-sulfo LacNAc-positive blood dendritic cells (SlanDCs). PLoS One 6:e16315, 2011. [Abstract]

Bronson PG, Goldstein BA, Ramsay PP, Beckman KB, Noble JA, Lane JA, Seldin MF, Kelly JA, Harley JB, Moser KL, Gaffney PM, Behrens TW, Criswell LA, Barcellos LF. The rs4774 CIITA missense variant is associated with risk of systemic lupus erythematosus. Genes Immun 12:667-671, 2011. [Abstract]

Bruner BF, Vista ES, Wynn DM, James JA. Epitope specificity of myeloperoxidase antibodies: identification of candidate human immunodominant epitopes. Clin Exp Immunol 164:330-336, 2011. [Abstract]

Chung SA, Taylor KE, Graham RR, Nititham J, Lee AT, Ortmann WA, Jacob CO, Alarcon-Riquelme ME, Tsao BP, Harley JB, Gaffney PM, Moser KL, SLEGEN, Petri M, Demirci FY, Kamboh MI, Manzi S, Gregersen PK, Langefeld CD, Behrens TW, Criswell LA. Differential Genetic Associations for Systemic Lupus Erythematosus Based on Anti-dsDNA Autoantibody Production. PLoS Genet 7:e1001323, 2011. [Abstract]

Crowe SR, Garman L, Engler RJ, Farris AD, Ballard JD, Harley JB, James JA. Anthrax vaccination induced anti-lethal factor IgG: Fine specificity and neutralizing capacity. Vaccine 29:3670-3678, 2011. [Abstract]

* Crowe SR, Merrill JT, Vista ES, Dedeke AB, Thompson DM, Stewart S, Guthridge JM, Niewold TB, Franek BS, Air GM, Thompson LF, James JA. Influenza vaccination responses in human systemic lupus erythematosus: impact of clinical and demographic features. Arthritis Rheum 63:2396-2406, 2011. [Abstract]

Dall’era M, Chakravarty EF. Treatment of mild, moderate, and severe lupus erythematosus: focus on new therapies. Curr Rheumatol Rep 13:308-316, 2011. [Abstract]

Deshmukh HA, Maiti AK, Kim-Howard XR, Rojas-Villarraga A, Guthridge JM, Anaya JM, Nath SK. Evaluation of 19 autoimmune disease-associated loci with rheumatoid arthritis in a Colombian population: evidence for replication and gene-gene interaction. J Rheumatol 38:1866-1870, 2011. [Abstract]

Dillon S, Aggarwal R, Harding JW, Li LJ, Weissman MH, Li S, Cavett JW, Sevier ST, Ojwang JW, D’Souza A, Harley JB, Hal SR. Klinefelter’s syndrome (47,XXY) among men with systemic lupus erythematosus. Acta Paediatr 100:819-823, 2011. [Abstract]

Dozmorov IM, Jarvis J, Saban R, Benbrook DM, Wakeland E, Aksentijevich I, Ryan J, Chiorazzi N, Guthridge JM, Drewe E, Tighe PJ, Centola M, Lefkovits I. Internal standard-based analysis of microarray data2–Analysis of functional associations between HVE-genes. Nucleic Acids Res 39:7881-7899, 2011. [Abstract]

Dozmorov MG, Giles CB, Wren JD. Predicting gene ontology from a global meta-analysis of 1-color microarray experiments. BMC Bioinformatics 12 Suppl 10:S14, 2011. [Abstract]

Dozmorov MG, Wren JD. High-throughput processing and normalization of one-color microarrays for transcriptional meta-analyses. BMC Bioinformatics 12 Suppl 10:S2, 2011. [Abstract]

Dumas EK, Cox PM, Fullenwider CO, Nguyen M, Centola M, Frank MB, Dozmorov I, James JA, Farris AD. Anthrax lethal toxin-induced gene expression changes in mouse lung. Toxins 3:1111-1130, 2011. [Abstract]

Fjeldstad C, Bemben M, Pardo G. Reduced retinal nerve fiber layer and macular thickness in patients with multiple sclerosis with no history of optic neuritis identified by the use of spectral domain high-definition optical coherence tomography. J Clin Neurosci 18:1469-1472, 2011.[Abstract]

Fu Q, Zhao J, Qian X, Wong JL, Kaufman KM, Yu CY, Hwee SH, Tan Tock Seng Hospital Lupus Study Group, Mok MY, Harley JB, Guthridge JM, Song YW, Cho SK, Bae SC, Grossman JM, Hahn BH, Arnett FC, Shen N, Tsao BP. Association of a functional IRF7 variant with systemic lupus erythematosus. Arthritis Rheum 63:749-754, 2011. [Abstract]

Gilkeson G, James J, Kamen D, Knackstedt T, Maggi D, Meyer A, Ruth N. The United States to Africa lupus prevalence gradient revisited. Lupus 20:1095-1103, 2011. [Abstract]

Gupta R, Wayangankar SA, Targoff IN, Hennebry TA.  Clinical cardiac involvement in idiopathic inflammatory myopathies: A systematic review. Int J Cardiol 148:261-270, 2011. [Abstract]

Htoon J, Nadig A, Hughes T, Yavuz S, Direskeneli H, Saruhan-Direskeneli G, Sawalha AH. IL18 Polymorphism is associated with Behcet’s disease but not lupus in patients from Turkey. J Rheumatol 38:962-963, 2011. [Abstract]

* Hughes T, Kim-Howard X, Kelly JA, Kaufman KM, Langefeld CD, Ziegler J, Sanchez E, Kimberly RP, Edberg JC, Ramsey-Goldman R, Petri M, Reveille JD, Martin J, Brown EE, Vila LM, Alarcon GS, James JA, Gilkeson GS, Moser KL, Gaffney PM, Merrill JT, Vyse TJ, Alarcon-Riquelme ME, on behalf of the BIOLUPUS network, Nath SK, Harley JB, Sawalha AH. Fine mapping and trans-ethnic genotyping establish IL2/IL21 genetic association with lupus and localize this genetic effect to IL21. Arthritis Rheum 63:1689-1697, 2011. [Abstract]

Hughes T, Sawalha AH. The role of epigenetic variation in the pathogenesis of systemic lupus erythematosus. Arthritis Res Ther 13:245, 2011. [Abstract]

* Jeffries M, Dozmorov M, Tang Y, Merrill JT, Wren JD, Sawalha AH. Genome-wide DNA methylation patterns in CD4+ T cells from patients with systemic lupus erythematosus. Epigenetics 6: 593-601, 2011. [Abstract]

Kurien BT, Dillon SP, Dorri Y, D’Souza A, Scofield RH. Curcumin does not bind or intercalate into DNA and a note on the gray side of curcumin. Int J Cancer 128:242-245, 2011. [Abstract]

Kurien BT, Dorri Y, Dillon S, Dsouza A, Scofield RH. An overview of Western blotting for determining antibody specificities for immunohistochemistry. Methods Mol Biol 717:55-67, 2011. [Abstract]

Kurien BT, Porter A, Dorri Y, Iqbal S, D’Sousa A, Singh A, Asfa S, Cartellieri M, Mathias K, Matsumoto H, Bachmann M, Hensley K, Scofield RH. Degree of modification of Ro60 by the lipid peroxidation by-product 4-hydroxy-2-nonenal may differentially induce Sjögren’s syndrome or systemic lupus erythematosus in BALB/c mice. Free Radic Biol Med 50:1222-1233, 2011. [Abstract]

* Lee DM, Jackson KW, Knowlton N, Wages J, Alaupovic P, Samuelsson O, Saeed A, Centola M, Attman PO. Oxidative stress and inflammation in renal patients and healthy subjects. PLoS One 6:e22360, 2011. [Abstract]

* Lessard CJ, Adrianto I, Kelly JA, Kaufman KM, Grundahl KM, Adler A, Williams AH, Gallant CJ, Marta E.Alarcon-Riquelme on behalf of the BIOLUPUS and GENLES Networks, Anaya JM, Bae SC, Boackle SA, Brown EE, Chang DM, Criswell LA, Edberg JC, Freedman BI, Gregersen PK, Gilkeson GS, Jacob CO, James JA, Kamen DL, Kimberly RP, Martin J, Merrill JT, Niewold TB, Park SY, Petri MA, Pons-Estel BA, Ramsey-Goldman R, Reveille JD, Song YW, Stevens AM, Tsao BP, Vila LM, Vyse TJ, Yu CY, Guthridge JM, Bruner GR, Langefeld CD, Montgomery C, Harley JB, Scofield RH, Gaffney PM, Moser KL. Identification of a systemic lupus erythematosus susceptibility locus at 11p13 between PDHX and CD44 in a multiethnic study. Am J Hum Genet 88:83-91, 2011.  [Abstract]

* Lupu C, Zhu H, Popescu NI, Wren JD, Lupu F. Novel protein ADTRP regulates TFPI expression and function in human endothelial cells in normal conditions and in response to androgen. Blood 118:4463-4471, 2011.[Abstract]

Mechelli R, Anderson J, Vittori D, Coarelli G, Annibali V, Cannoni S, Aloisi F, Salvetti M, James J, Ristori G. Epstein-Barr virus nuclear antigen-1 B-cell epitopes in multiple sclerosis twins. Mult Scler 17:1290-1294, 2011.[Abstract]

Mowry EM, James JA, Krupp LB, Waubant E. Vitamin D status and antibody levels to common viruses in pediatric-onset multiple sclerosis. Mult Scler  17:666-671,2011.  [Abstract]

* Namjou B, Kothari PH, Kelly JA, Glenn SB, Ojwang JO, Adler A, Alarcon-Riquelme ME, Gallant CJ, Boackle SA, Criswell LA, Kimberly RP, Brown E, Edberg J, Stevens AM, Jacob CO, Tsao BP, Gilkeson GS, Kamen DL, Merrill JT, Petri M, Goldman RR, Vila LM, Anaya JM, Niewold TB, Martin J, Pons-Estel BA, Sabio JM, Callejas JL, Vyse TJ, Bae SC, Perrino FW, Freedman BI, Scofield RH, Moser KL, Gaffney PM, James JA, Langefeld CD, Kaufman KM, Harley JB, Atkinson JP. Evaluation of the TREX1 gene in a large multi-ancestral lupus cohort. Genes Immun 12:270-279, 2011.  [Abstract]

Navarra SV, Ishimori ML, Uy EA, Hamijoyo L, Sama J, James JA, Holers VM, Weisman MH. Studies of Filipino patients with systemic lupus erythematosus (SLE): Autoantibody profile of first degree relatives. Lupus 20:537-543, 2011. [Abstract]

Ramos PS, Criswell LA, Moser KL, Comeau ME, Williams AH, Pajewski NM, Chung SA, Graham RR, Zidovetzki R, Kelly JA, Kaufman KM, Jacob CO, Vyse TJ, Tsao BP, Kimberly RP, Gaffney PM, Alarcon-Riquelme ME, Harley JB, Langefeld CD, for The International Consortium on the Genetics of Systemic Erythematosus. A Comprehensive analysis of shared loci between systemic lupus erythematosus (SLE) and sixteen autoimmune diseases reveals limited genetic overlap. PLoS Genet 7:e1002406, 2011. [Abstract]

Ramos PS, Williams AH, Ziegler JT, Comeau ME, Guy RT, Lessard CJ, Edberg JC, Zidovetzki R, Criswell LA, Gaffney PM, Graham DC, Graham RR, Kelly JA, Kaufman KM, Brown EE, Alarcon GS, Petri MA, Reveille JD, McGwin G, Vila LM, Ramsey-Goldman R, Jacob CO, Vyse TJ, Tsao BP, Harley JB, Kimberly RP, Alarcón-Riquelme ME, Langefeld CD, Moser KL. Genetic analyses of interferon pathway-related genes reveals multiple new loci associated with systemic lupus erythematosus. Arthritis Rheum 63:2049-2057,2011. [Abstract]

* Rasmussen A, Sevier S, Kelly JA, Glenn SB, Aberle T, Cooney CM, Grether A, James E, Ning J, Tesiram J, Morrisey J, Powe T, Drexel M, Daniel W, Namjou B, Ojwang JO, Nguyen KL, Cavett JW, Te JL, James JA, Scofield RH, Moser K, Gilkeson GS, Kamen DL, Carson CW, Quintero-Del-Rio AI, del Carmen Ballesteros M, Punaro MG, Karp DR, Wallace DJ, Weisman M, Merrill JT, Rivera R, Petri MA, Albert DA, Espinoza LR, Utset TO, Shaver TS, Arthur E, Anaya JM, Bruner GR, Harley JB.  The Lupus Family Registry and Repository. Rheumatology (Oxford) 50:47-59, 2011.[ Abstract ]

Ratnamala U, Lyle R, Raval R, Singh R, Vishnupriya S, Himabindu P, Rao VV, Aggarwal S, Paluru P, Bartoloni L, Young TL, Paoloni-Giacobino A, Morris MA, Nath SK, Antonarakis SE, Uppala R. Refinement of the X-linked nonsyndromic high-grade myopia locus MYP1 on Xq28 and exclusion of 13 known positional candidate genes by direct sequencing. Invest Ophthalmol Vis Sci 52:6814-6819, 2011. [Abstract]

Ritterhouse LL, Crowe SR, Niewold TB, Kamen DL, Macwana SR, Roberts VC, Dedeke AB, Harley JB, Scofield RH, Guthridge JM, James JA. Vitamin D deficiency is associated with an increased autoimmune response in healthy individuals and in patients with systemic lupus erythematosus. Ann Rheum Dis 70:1569-1574, 2011. [Abstract]

* Ritterhouse LL, Crowe SR, Niewold TB, Merrill JT, Roberts VC, Dedeke AB, Neas BR, Thompson LF, Guthridge JM, James JA. B lymphocyte stimulator levels in systemic lupus erythematosus: Higher circulating levels in African American patients and increased production after influenza vaccination in patients with low baseline levels. Arthritis Rheum 63:3931-3941, 2011. [Abstract]

Rybicki BA, Levin AM, McKeigue P, Datta I, Gray-McGuire C, Colombo M, Reich D, Burke RR, Iannuzzi MC. A genome-wide admixture scan for ancestry-linked genes predisposing to sarcoidosis in African-Americans. Genes Immun 12:67-77, 2011. [Abstract]

Rydzanicz M, Nath SK, Sun C, Podfigurna-Musielak M, Frajdenberg A, Mrugacz M, Winters D, Ratnamala U, Radhakrishna U, Bejjani BA, Gajecka M. Identification of novel suggestive loci for high-grade myopia in Polish families. Mol Vis 17:2028-2039, 2011. [Abstract]

* Sanchez E, Comeau ME, Freedman BI, Kelly JA, Kaufman KM, Langefeld CD, Brown EE, Alarcon GS, Kimberly RP, Edberg JC, Ramsey-Goldman R, Petri M, Reveille JD, Vila LM, Merrill JT, Tsao BP, Kamen DL, Gilkeson GS, James JA, Vyse TJ, Gaffney PM, Jacob CO, Niewold TB, Richardson BC, Harley JB, Alarcon-Riquelme ME, Sawalha AH. Identification of novel genetic susceptibility loci in African-American lupus patients using a candidate gene association study. Arthritis Rheum 70:1752-1757, 2011. [Abstract]

* Sánchez E, Comeau ME, Freedman BI, Kelly JA, Kaufman KM, Langefeld CD, Brown EE, Alarcón GS, Kimberly RP, Edberg JC, Ramsey-Goldman R, Petri M, Reveille JD, Vilá LM, Merrill JT, Tsao BP, Kamen DL, Gilkeson GS, James JA, Vyse TJ, International Consortium on the Genetics of Systemic Lupus Erythematosus, Gaffney PM, Jacob CO, Niewold TB, Richardson BC, Harley JB, Alarcón-Riquelme ME, Sawalha AH. Identification of novel genetic susceptibility loci in African-American lupus patients using a candidate gene association study. Arthritis Rheum 63:3493-3501, 2011. [Abstract]

Sasaki S, Sullivan M, Narvaez CF, Holmes TH, Furman D, Zheng NY, Nishtala M, Wrammert J, Smith K, James JA, Dekker CL, Davis MM, Wilson PC, Greenberg HB, He XS. Limited efficacy of inactivated influenza vaccine in elderly individuals is associated with decreased production of vaccine-specific antibodies. J Clin Invest 121:3109-3119, 2011. [Abstract]

Sawalha AH, Hughes T, Nadig A, Yilmaz V, Aksu K, Keser G, Cefle A, Yazici A, Ergen A, Alarcón-Riquelme ME, Salvarani C, Casali B, Direskeneli H, Saruhan-Direskeneli G. A putative functional variant within the ubiquitin-associated domain-containing protein 2 gene (UBAC2) is associated with increased risk of Behcet’s disease. Arthritis Rheum 63:3607-3612, 2011.[Abstract]

Scofield RH. Vasculitis in Sjögren’s Syndrome. Curr Rheumatol Rep 13:482-488, 2011. [Abstract]

Segal BM, Nazmul-Hossain AN, Patel K, Hughes P, Moser KL, Rhodus NL. Genetics and genomics of Sjögren’s syndrome: research provides clues to pathogenesis and novel therapies. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 111:673-680, 2011. [Abstract]

* Sestak AL, Furnrohr BG, Harley JB, Merrill JT, Namjou B. The genetics of systemic lupus erythematosus and implications for targeted therapy. Ann Rheum Dis 70 Suppl 1:i37-i43, 2011. [Abstract]

Sreih A, Ezzeddine R, Leng L, Lachance A, Yu G, Mizue Y, Subrahmanyan L, Pons-Estel BA, Abelson AK, Gunnarsson I, Svenungsson E, Cavett J, Glenn S, Zhang L, Montgomery R, Perl A, Salmon J, Alarcón-Riquelme ME, Harley JB, Bucala R. Dual effect of the macrophage migration inhibitory factor gene on the development and severity of human systemic lupus erythematosus. Arthritis Rheum 63:3942-3951, 2011. [Abstract]

* Tan W, Sunahori K, Zhao J, Deng Y, Kaufman KM, Kelly JA, Langefeld CD, Williams AH, Comeau ME, Ziegler JT, Marion MC, Bae SC, Lee J.H., Lee JS, Chang DM, Wook SY, Yu CY, Kimberly RP, Edberg JC, Brown EE, Petri MA, Ramsey-Goldman R, Vila LM, Reveille JD, Alarcon-Riquelme ME, Harley JB, Boackle SA, Stevens AM, Scofield R.H., Merrill JT, Freedman BI, Anaya JM, Criswell LA, Jacob CO, Vyse TJ, Niewold TB, Gaffney PM, Moser KL, Gilkeson GS, Kamen DL, James JA, Grossman JM, Hahn BH, Tsokos GC, Tsao BP, on behalf of the BIOLUPUS GENLES networks. Association of PPP2CA polymorphisms with SLE susceptibility in multiple ethnic groups. Arthritis Rheum 63:2755-2763, 2011. [Abstract]

Taylor KE, Chung SA, Graham RR, Ortmann WA, Lee AT, Langefeld CD, Jacob CO, Kamboh MI, Alarcon-Riquelme ME, Tsao BP, Moser KL, Gaffney PM, Harley JB, Petri M, Manzi S, Gregersen PK, Behrens TW, Criswell LA. Risk alleles for systemic lupus erythematosus in a large case-control collection and associations with clinical subphenotypes. PLoS Genet 7:e1001311, 2011. [Abstract]

Thanou-Stavraki A, Sawalha AH. An update on belimumab for the treatment of lupus. Biologics 5:33-43, 2011. [Abstract]

Thanou-Stavraki A, Sawalha AH, Crowson AN, Harley JB. Noodling and Mycobacterium marinum infection mimicking seronegative rheumatoid arthritis complicated by anti-TNFa therapy. Arthritis Care Res (Hoboken ) 63:160-164, 2011.  [Abstract]

Todd DJ, Knowlton N, Amato M, Frank MB, Schur PH, Izmailova ES, Roubenoff R, Shadick NA, Weinblatt ME, Centola M, Lee DM. Erroneous augmentation of multiplex assay measurements in patients with rheumatoid arthritis due to heterophilic binding by serum rheumatoid factor. Arthritis Rheum 63:894-903, 2011. [Abstract]

Waubant E, Mowry EM, Krupp L, Chitnis T, Yeh EA, Kuntz N, Ness J, Chabas D, Strober J, McDonald J, Belman A, Milazzo M, Gorman M, Weinstock-Guttman B, Rodriguez M, Oksenberg JR, James JA, For the US Pediatric MS Network. Common viruses associated with lower pediatric multiple sclerosis risk. Neurology 76:1989-1995, 2011. [Abstract]

Webb R, Kelly JA, Somers EC, Hughes T, Kaufman KM, Sanchez E, Nath SK, Bruner G, Alarcon-Riquelme ME, Gilkeson GS, Kamen DL, Richardson BC, Harley JB, Sawalha AH.  Early disease onset is predicted by a higher genetic risk for lupus and is associated with a more severe phenotype in lupus patients. Ann Rheum Dis 70:151-156, 2011. [Abstract ]

Weckerle CE, Franek BS, Kelly JA, Kumabe M, Mikolaitis RA, Green SL, Utset TO, Jolly M, James JA, Harley JB, Niewold TB. Network analysis of associations between serum interferon alpha activity, autoantibodies, and clinical features in systemic lupus erythematosus. Arthritis Rheum 63:1044-1053,  2011. [Abstract]

Wen F, Ellingson SM, Kyogoku C, Peterson EJ, Gaffney PM. Exon 6 variants carried on systemic lupus erythematosus (SLE) risk haplotypes modulate IRF5 function. Autoimmunity 44:82-89, 2011. [Abstract]

Wirapati P, Forner K, Delgado-Vega A, Alarcon-Riquelme M, Delorenzi M, Wojcik J.  Detecting epistasis with restricted response patterns in pairs of Biallelic Loci. Ann Hum Genet 75:133-145, 2011. [Abstract]

Wren JD. Question answering systems in biology and medicine – the time is now. Bioinformatics 27:2025-2026,  2011. [Abstract]

Xu Z, Potula HH, Vallurupalli A, Perry D, Baker H, Croker BP, Dozmorov I, Morel L. Cyclin-dependent kinase inhibitor Cdkn2c regulates B Cell homeostasis and function in the NZM2410-derived murine lupus susceptibility locus Sle2c1. J Immunol  186:6673-6682,2011. [Abstract]

Yan XJ, Dozmorov I, Li W, Yancopoulos S, Sison C, Centola M, Jain P, Allen SL, Kolitz JE, Rai KR, Chiorazzi N, Sherry B. Identification of outcome-correlated cytokine clusters in chronic lymphocytic leukemia. Blood 118:5201-5210, 2011. [Abstract]

* Zhao J, Wu H, Khosravi M, Cui H, Qian X, Kelly JA, Kaufman KM, Langefeld CD, Williams AH, Comeau ME, Ziegler JT, Marion MC, Adler A, Glenn SB, Alarcon-Riquelme ME, BIOLUPUS N, GENLES N, Pons-Estel BA, Harley JB, Bae SC, Bang SY, Cho SK, Jacob CO, Vyse TJ, Niewold TB, Gaffney PM, Moser KL, Kimberly RP, Edberg JC, Brown EE, Alarcon GS, Petri MA, Ramsey-Goldman R, Vila LM, Reveille JD, James JA, Gilkeson GS, Kamen DL, Freedman BI, Anaya JM, Merrill JT, Criswell LA, Scofield RH, Stevens AM, Guthridge JM, Chang DM, Song YW, Park JA, Lee EY, Boackle SA, Grossman JM, Hahn BH, Goodship TH, Cantor RM, Yu CY, Shen N, Tsao BP. Association of genetic variants in complement factor h and factor h-related genes with systemic lupus erythematosus susceptibility. PLoS Genet 7:e1002079, 2011. [Abstract]

Cardiovascular Biology Research Program

Arbuckle JL, Rahman NS, Zhao S, Rodgers W, Rodgers KK. Elucidating the domain architecture and functions of non-core RAG1: the capacity of a non-core zinc-binding domain to function in nuclear import and nucleic acid binding. BMC Biochem 12:23, 2011. [Abstract]

Calloway N, Owens T, Corwith K, Rodgers W, Holowka D, Baird B. Stimulated association of STIM1 and Orai1 is regulated by the balance of PtdIns(4,5)P between distinct membrane pools. J Cell Sci 124:2602-2610, 2011. [Abstract]

Fu J, Wei B, Wen T, Johansson ME, Liu X, Bradford E, Thomsson KA, McGee S, Mansour L, Tong M, McDaniel JM, Sferra TJ, Turner JR, Chen H, Hansson GC, Braun J, Xia L. Loss of intestinal core 1-derived O-glycans causes spontaneous colitis in mice. J Clin Invest 121:1657-1666, 2011. [Abstract]

Griffin CT, Curtis CD, Davis RB, Muthukumar V, Magnuson T. The chromatin-remodeling enzyme BRG1 modulates vascular Wnt signaling at two levels. Proc Natl Acad Sci U S A 108:2282-2287, 2011.  [Abstract]

* He T, Smith N, Saunders D, Doblas S, Watanabe Y, Hoyle J, Silasi-Mansat R, Lupu F, Lerner M, Brackett DJ, Towner RA. Molecular MRI assessment of vascular endothelial growth factor receptor-2 in rat C6 gliomas. J Cell Mol Med 15:837-849, 2011. [Abstract]

* Lupu C, Zhu H, Popescu NI, Wren JD, Lupu F. Novel protein ADTRP regulates TFPI expression and function in human endothelial cells in normal conditions and in response to androgen. Blood 118:4463-4471, 2011. [Abstract]

Marcello MR, Jia W, Leary JA, Moore KL, Evans JP. Lack of tyrosylprotein sulfotransferase-2 activity results in altered sperm-egg interactions and loss of ADAM3 and ADAM6 in epididymal sperm. J Biol Chem 286:13060-13070, 2011. [Abstract]

Miner JJ, Shao B, Wang Y, Chichili GR, Liu Z, Klopocki AG, Yago T, McDaniel JM, Rodgers W, Xia L, McEver RP. Cytoplasmic domain of P-selectin glycoprotein ligand-1 facilitates dimerization and export from the endoplasmic reticulum. J Biol Chem 286:9577-9586, 2011. [Abstract]

Sarangapani KK, Marshall BT, McEver RP, Zhu C. Molecular stiffness of selectins. J Biol Chem 286:9567-9576, 2011. [Abstract]

Sarangapani KK, Qian J, Chen W, Zarnitsyna VI, Mehta P, Yago T, McEver RP, Zhu C. Regulation of catch bonds by rate of force application. J Biol Chem 286:32749-32761, 2011. [Abstract]

Shao B, Wahrenbrock MG, Yao L, David T, Coughlin SR, Xia L, Varki A, McEver RP. Carcinoma mucins trigger reciprocal activation of platelets and neutrophils in a murine model of Trousseau syndrome. Blood 118:4015-4023, 2011. [Abstract]

Wallays G, Nuyens D, Silasi-Mansat R, Souffreau J, Callaerts-Vegh Z, Van Nuffelen A., Moons L, D’hooge R, Lupu F, Carmeliet P, Collen D, Dewerchin M. Notch3 Arg170Cys knock-in mice display pathologic and clinical features of the neurovascular disorder cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy. Arterioscler Thromb Vasc Biol 31:2881-2888, 2011. [Abstract]

*  Webb CF, Bryant J, Popowski M, Allred L, Kim D, Harriss J, Schmidt C, Miner CA, Rose K, Cheng HL, Griffin C, Tucker PW. The ARID family transcription factor Bright is required for both hematopoietic stem cell and B lineage development. Mol Cell Biol 31:1041-1053, 2011.  [Abstract]

Westmuckett AD, Thacker KM, Moore KL. Tyrosine sulfation of native mouse PSGL-1 is required for optimal leukocyte rolling on P-selectin in vivo. PLoS One 6:e20406, 2011. [Abstract]

Yu L, Qin L, Zhang H, He Y, Chen H, Pober JS, Tellides G, Min W. AIP1 prevents graft arteriosclerosis by inhibiting interferon-{gamma}-dependent smooth muscle cell proliferation and intimal expansion. Circ Res 109:418-427, 2011. [Abstract]

Zarbock A, Ley K, McEver RP, Hidalgo A. Leukocyte ligands for endothelial selectins: specialized glycoconjugates that mediate rolling and signaling under flow. Blood 118:6743-6751, 2011. [Abstract]

Zarpellon A, Celikel R, Roberts JR, McClintock RA, Mendolicchio GL, Moore KL, Jing H, Varughese KI, Ruggeri ZM. Binding of {alpha}-thrombin to surface-anchored platelet glycoprotein Ib{alpha} sulfotyrosines through a two-site mechanism involving exosite I. Proc Natl Acad Sci U S A 108:8628-8633, 2011. [Abstract]

Zhang X, Yu H, Lou JR, Zheng J, Zhu H, Popescu NI, Lupu F, Lind SE, Ding WQ.  microRNA-19 (miR-19) regulates tissue factor expression in breast cancer cells. J Biol Chem 286:1429-1435, 2011. [Abstract]

Zsuzsa S, Kiss A, Erdodi F, Setiadi H, Debreceni IB, Nagy B, Kappelmayer J. Protein phosphatase inhibitor calyculin – A modulates activation markers in TRAP-stimulated human platelets. Platelets 21:555-562, 2011.

Cell Cycle and Cancer Biology Research Program

Bugreev DV, Pezza RJ, Mazina OM, Voloshin ON, Camerini-Otero RD, Mazin AV. The resistance of DMC1 D-loops to dissociation may account for the DMC1 requirement in meiosis. Nat Struct Mol Biol 18:56-60, 2011. [Abstract]

Daum JR, Potapova TA, Sivakumar S, Daniel JJ, Flynn JN, Rankin S, Gorbsky GJ. Cohesion fatigue induces chromatid separation in cells delayed at metaphase. Curr Biol 21:1018-1024,2011. [Abstract]

Kim S, Zaghloul NA, Bubenshchikova E, Oh EC, Rankin S, Katsanis N, Obara T, Tsiokas L. Nde1-mediated inhibition of ciliogenesis affects cell cycle re-entry. Nat Cell Biol 13:351-360, 2011. [Abstract]

Potapova TA, Sivakumar S, Flynn JN, Li R, Gorbsky GJ. Mitotic progression becomes irreversible in prometaphase and collapses when Wee1 and Cdc25 are inhibited. Mol Biol Cell 22:1191-1206, 2011. [Abstract]

Wu FM, Nguyen JV, Rankin S. A conserved motif at the C-terminus of sororin is required for sister chromatid cohesion. J Biol Chem 286:3579-3586, 2011. [Abstract]

Clinical Pharmacology Research Program

* Adrianto I, Wen F, Templeton A, Wiley G, King JB, Lessard CJ, Bates JS, Hu Y, Kelly JA, Kaufman KM, Guthridge JM, Alarcón-Riquelme ME, Anaya JM, Bae SC, Bang SY, Boackle SA, Brown EE, Petri MA, Gallant C, Ramsey-Goldman R, Reveille JD, Vila LM, Criswell LA, Edberg JC, Freedman BI, Gregersen PK, Gilkeson GS, Jacob CO, James JA, Kamen DL, Kimberly RP, Martin J, Merrill JT, Niewold TB, Park SY, Pons-Estel BA, Scofield RH, Stevens AM, Tsao BP, Vyse TJ, Langefeld CD, Harley JB, Moser KL, Webb CF, Humphrey MB, Montgomery CG, Gaffney PM. Association of a functional variant downstream of TNFAIP3 with systemic lupus erythematosus. Nat Genet 43:253-258, 2011. [Abstract]

* Crowe SR, Merrill JT, Vista ES, Dedeke AB, Thompson DM, Stewart S, Guthridge JM, Niewold TB, Franek BS, Air GM, Thompson LF, James JA. Influenza vaccination responses in human systemic lupus erythematosus: impact of clinical and demographic features. Arthritis Rheum 63:2396-2406, 2011. [Abstract]

Furie R, Petri M, Zamani O, Cervera R, Wallace DJ, Tegzova D, Sanchez-Guerrero J, Schwarting A, Merrill JT, Chatham WW, Stohl W, Ginzler EM, Hough DR, Zhong ZJ, Freimuth W, Van Vollenhoven RF, Study Group. A phase III, randomized, placebo-controlled study of belimumab, a monoclonal antibody that inhibits B lymphocyte stimulator, in patients with systemic lupus erythematosus. Arthritis Rheum 63:3918-3930, 2011. [Abstract]

Hanly JG, Urowitz MB, Jackson D, Bae SC, Gordon C, Wallace DJ, Clarke A, Bernatsky S, Vasudevan A, Isenberg D, Rahman A, Sanchez-Guerrero J, Romero-Diaz J, Merrill JT, Fortin PR, Gladman DD, Bruce IN, Steinsson K, Khamashta M, Alarcón GS, Fessler B, Petri M, Manzi S, Nived O, Sturfelt G, Ramsey-Goldman R, Dooley MA, Aranow C, van Vollenhoven R., Ramos-Casals M, Zoma A, Kalunian K, Farewell V, for the Systemic Lupus International Collaborating Clinics (SLICC). SF-36 summary and subscale scores are reliable outcomes of neuropsychiatric events in systemic lupus erythematosus. Ann Rheum Dis 70:961-967, 2011. [Abstract]

Hanly JG, Urowitz MB, Su L, Bae SC, Gordon C, Clarke A, Bernatsky S, Vasudevan A, Isenberg D, Rahman A, Wallace DJ, Fortin PR, Gladman D, Romero-Dirz J, Sanchez-Guerrero J, Dooley MA, Bruce I, Steinsson K, Khamashta M, Manzi S, Ramsey-Goldman R, Sturfelt G, Nived O, van Vollenhoven R., Ramos-Casals M, Aranow C, Mackay M, Kalunian K, Alarcon GS, Fessler BJ, Ruiz-Irastorza G, Petri M, Lim S, Kamen D, Peschken C, Farewell V, Thompson K, Theriault C, Merrill JT. Autoantibodies as biomarkers for the prediction of neuropsychiatric events in systemic lupus erythematosus. Ann Rheum Dis 70:1726-1732, 2011. [Abstract]

* Hughes T, Kim-Howard X, Kelly JA, Kaufman KM, Langefeld CD, Ziegler J, Sanchez E, Kimberly RP, Edberg JC, Ramsey-Goldman R, Petri M, Reveille JD, Martin J, Brown EE, Vila LM, Alarcon GS, James JA, Gilkeson GS, Moser KL, Gaffney PM, Merrill JT, Vyse TJ, Alarcon-Riquelme ME, BIOLUPUS network, Nath SK, Harley JB, Sawalha AH. Fine mapping and transethnic genotyping establish IL2/IL21 genetic association with lupus and localize this genetic effect to IL21. Arthritis Rheum 63:1689-1697, 2011. [Abstract]

Ippolito A, Wallace D, Gladman D, Fortin P, Urowitz M, Werth V, Costner M, Gordon C, Alarcon G, Ramsey-Goldman R, Maddison P, Clarke A, Bernatsky S, Manzi S, Bae SC, Merrill J, Ginzler E, Hanly J, Nived O, Sturfelt G, Sanchez-Guerrero J, Bruce I, Aranow C, Isenberg D, Zoma A, Magder L, Buyon J, Kalunian K, Dooley M, Steinsson K, Vollenhoven R, Stoll T, Weisman M, Petri M. Autoantibodies in systemic lupus erythematosus: comparison of historical and current assessment of seropositivity. Lupus 20:250-255, 2011. [Abstract]

Isenberg DA, Allen E, Farewell V, D’Cruz D, Alarcon GS, Aranow C, Bruce IN, Dooley MA, Fortin PR, Ginzler EM, Gladman DD, Hanly JG, Inanc M, Kalunian K, Khamashta M, Merrill JT, Nived O, Petri M, Ramsey-Goldman R, Sturfelt G, Urowitz M, Wallace DJ, Gordon C, Rahman A. An assessment of disease flare in patients with systemic lupus erythematosus: a comparison of BILAG 2004 and the flare version of SELENA. Ann Rheum Dis 70:54-59, 2011. [Abstract]

* Jeffries M, Dozmorov M, Tang Y, Merrill JT, Wren JD, Sawalha AH. Genome-wide DNA methylation patterns in CD4+ T cells from patients with systemic lupus erythematosus. Epigenetics 6: 593-601, 2011. [Abstract]

* Lessard CJ, Adrianto I, Kelly JA, Kaufman KM, Grundahl KM, Adler A, Williams AH, Gallant CJ, Marta E.Alarcon-Riquelme on behalf of the BIOLUPUS and GENLES Networks, Anaya JM, Bae SC, Boackle SA, Brown EE, Chang DM, Criswell LA, Edberg JC, Freedman BI, Gregersen PK, Gilkeson GS, Jacob CO, James JA, Kamen DL, Kimberly RP, Martin J, Merrill JT, Niewold TB, Park SY, Petri MA, Pons-Estel BA, Ramsey-Goldman R, Reveille JD, Song YW, Stevens AM, Tsao BP, Vila LM, Vyse TJ, Yu CY, Guthridge JM, Bruner GR, Langefeld CD, Montgomery C, Harley JB, Scofield RH, Gaffney PM, Moser KL. Identification of a systemic lupus erythematosus susceptibility locus at 11p13 between PDHX and CD44 in a multiethnic study. Am J Hum Genet 88:83-91, 2011.  [Abstract]

Merrill JT. Ending the 50-year drought of FDA drug approval for SLE. Bull NYU Hosp Jt Dis 69:238-242, 2011. [Article]

Merrill JT, Buyon JP, Furie RA, Latinis KM, Gordon C, Hsieh HJ, Brunetta PG. Assessment of flares in lupus patients enrolled in a phase II/III study of rituximab (EXPLORER). Lupus 20:709-716, 2011. [Abstract]

Merrill JT, Wallace DJ, Petri M, Kirou KA, Yao Y, White WI, Robbie G, Levin R, Berney SM, Chindalore V, Olsen N, Richman L, Le C, Jallal B, White B, for the Lupus Interferon Skin Activity (LISA) Study Investigators. Safety profile and clinical activity of sifalimumab, a fully human anti-interferon {alpha} monoclonal antibody, in systemic lupus erythematosus: a phase I, multicentre, double-blind randomised study. Ann Rheum Dis 70:1905-1913, 2011.[Abstract]

* Namjou B, Kothari PH, Kelly JA, Glenn SB, Ojwang JO, Adler A, Alarcon-Riquelme ME, Gallant CJ, Boackle SA, Criswell LA, Kimberly RP, Brown E, Edberg J, Stevens AM, Jacob CO, Tsao BP, Gilkeson GS, Kamen DL, Merrill JT, Petri M, Goldman RR, Vila LM, Anaya JM, Niewold TB, Martin J, Pons-Estel BA, Sabio JM, Callejas JL, Vyse TJ, Bae SC, Perrino FW, Freedman BI, Scofield RH, Moser KL, Gaffney PM, James JA, Langefeld CD, Kaufman KM, Harley JB, Atkinson JP. Evaluation of the TREX1 gene in a large multi-ancestral lupus cohort. Genes Immun 12:270-279, 2011.  [Abstract]

Peterfy CG, Countryman P, Gabriele A, Shaw T, Anisfeld A, Tsuji W, Olech E, Gaylis NB, Conaghan PG, Strand V, Dicarlo J. Magnetic resonance imaging in rheumatoid arthritis clinical trials: emerging patterns based on recent experience. J Rheumatol 38:2023-2030, 2011. [Abstract]

* Rasmussen A, Sevier S, Kelly JA, Glenn SB, Aberle T, Cooney CM, Grether A, James E, Ning J, Tesiram J, Morrisey J, Powe T, Drexel M, Daniel W, Namjou B, Ojwang JO, Nguyen KL, Cavett JW, Te JL, James JA, Scofield RH, Moser K, Gilkeson GS, Kamen DL, Carson CW, Quintero-Del-Rio AI, del Carmen Ballesteros M, Punaro MG, Karp DR, Wallace DJ, Weisman M, Merrill JT, Rivera R, Petri MA, Albert DA, Espinoza LR, Utset TO, Shaver TS, Arthur E, Anaya JM, Bruner GR, Harley JB.  The Lupus Family Registry and Repository. Rheumatology (Oxford) 50:47-59, 2011.[ Abstract ]

* Ritterhouse LL, Crowe SR, Niewold TB, Merrill JT, Roberts VC, Dedeke AB, Neas BR, Thompson LF, Guthridge JM, James JA. B lymphocyte stimulator levels in systemic lupus erythematosus: Higher circulating levels in African American patients and increased production after influenza vaccination in patients with low baseline levels. Arthritis Rheum 63:3931-3941, 2011. [Abstract]

Ruperto N, Hanrahan L, Alarcón G, Belmont H, Brey R, Brunetta P, Buyon J, Costner M, Cronin M, Dooley M, Filocamo G, Fiorentino D, Fortin P, Franks A, Jr., Gilkeson G, Ginzler E, Gordon C, Grossman J, Hahn B, Isenberg D, Kalunian K, Petri M, Sammaritano L, Sánchez-Guerrero J, Sontheimer R, Strand V, Urowitz M, von Feldt J., Werth V, Merrill J. International consensus for a definition of disease flare in lupus. Lupus 20:453-462, 2011. [Abstract]

* Sánchez E, Comeau ME, Freedman BI, Kelly JA, Kaufman KM, Langefeld CD, Brown EE, Alarcón GS, Kimberly RP, Edberg JC, Ramsey-Goldman R, Petri M, Reveille JD, Vilá LM, Merrill JT, Tsao BP, Kamen DL, Gilkeson GS, James JA, Vyse TJ, International Consortium on the Genetics of Systemic Lupus Erythematosus, Gaffney PM, Jacob CO, Niewold TB, Richardson BC, Harley JB, Alarcón-Riquelme ME, Sawalha AH. Identification of novel genetic susceptibility loci in African-American lupus patients using a candidate gene association study. Arthritis Rheum 63:3493-3501, 2011. [Abstract]

* Sanchez E, Nadig A, Richardson BC, Freedman BI, Kaufman KM, Kelly JA, Niewold TB, Kamen DL, Gilkeson GS, Ziegler JT, Langefeld CD, Alarcon GS, Edberg JC, Ramsey-Goldman R, Petri M, Brown EE, Kimberly RP, Reveille JD, Vila LM, Merrill JT, Anaya JM, James JA, Pons-Estel BA, Martin J, Park SY, Bang SY, Bae SC, Moser KL, Vyse TJ, Criswell LA, Gaffney PM, Tsao BP, Jacob CO, Harley JB, Alarcon-Riquelme ME, Sawalha AH. Phenotypic associations of genetic susceptibility loci in systemic lupus erythematosus. Ann Rheum Dis 70:1752-1757, 2011. [Abstract]

* Sestak AL, Furnrohr BG, Harley JB, Merrill JT, Namjou B. The genetics of systemic lupus erythematosus and implications for targeted therapy. Ann Rheum Dis 70 Suppl 1:i37-i43, 2011. [Abstract]

* Tan W, Sunahori K, Zhao J, Deng Y, Kaufman KM, Kelly JA, Langefeld CD, Williams AH, Comeau ME, Ziegler JT, Marion MC, Bae SC, Lee J.H., Lee JS, Chang DM, Wook SY, Yu CY, Kimberly RP, Edberg JC, Brown EE, Petri MA, Ramsey-Goldman R, Vila LM, Reveille JD, Alarcon-Riquelme ME, Harley JB, Boackle SA, Stevens AM, Scofield R.H., Merrill JT, Freedman BI, Anaya JM, Criswell LA, Jacob CO, Vyse TJ, Niewold TB, Gaffney PM, Moser KL, Gilkeson GS, Kamen DL, James JA, Grossman JM, Hahn BH, Tsokos GC, Tsao BP, on behalf of the BIOLUPUS GENLES networks. Association of PPP2CA polymorphisms with SLE susceptibility in multiple ethnic groups. Arthritis Rheum 63:2755-2763, 2011. [Abstract]

* Zhao J, Wu H, Khosravi M, Cui H, Qian X, Kelly JA, Kaufman KM, Langefeld CD, Williams AH, Comeau ME, Ziegler JT, Marion MC, Adler A, Glenn SB, Alarcon-Riquelme ME, BIOLUPUS N, GENLES N, Pons-Estel BA, Harley JB, Bae SC, Bang SY, Cho SK, Jacob CO, Vyse TJ, Niewold TB, Gaffney PM, Moser KL, Kimberly RP, Edberg JC, Brown EE, Alarcon GS, Petri MA, Ramsey-Goldman R, Vila LM, Reveille JD, James JA, Gilkeson GS, Kamen DL, Freedman BI, Anaya JM, Merrill JT, Criswell LA, Scofield RH, Stevens AM, Guthridge JM, Chang DM, Song YW, Park JA, Lee EY, Boackle SA, Grossman JM, Hahn BH, Goodship TH, Cantor RM, Yu CY, Shen N, Tsao BP. Association of genetic variants in complement factor h and factor h-related genes with systemic lupus erythematosus susceptibility. PLoS Genet 7:e1002079, 2011. [Abstract]

Coagulation Biology Laboratory

Ammollo CT, Semeraro F, Xu J, Esmon NL, Esmon CT. Extracellular histones increase plasma thrombin generation by impairing TM-dependent protein C activation. J Thromb Haemost 9:1795-1803, 2011. [Abstract]

Cervero J, Montes R, Espana F, Esmon CT, Hermida J. Limited ability to activate Protein C confers left atrial endocardium a thrombogenic phenotype: A Role in cardioembolic stroke? Stroke 42:2622-2624, 2011. [Abstract]

Disse J, Petersen HH, Larsen KS, Persson E, Esmon N, Esmon CT, Teyton L, Petersen LC, Ruf W. The endothelial protein c receptor supports tissue factor ternary coagulation initiation complex signaling through protease-activated receptors. J Biol Chem 286:5756-5767,2011. [Abstract]

Esmon CT. Extracellular histones zap platelets. Blood 118:3456-3457, 2011. [Abstract]

Esmon CT, Esmon NL.  The Link between vascular features and thrombosis. Annu Rev Physiol 73:503-514, 2011. [Abstract]

Esmon CT, Xu J, Lupu F. Innate immunity and coagulation. J Thromb Haemost 9 Suppl 1:182-188, 2011. [Abstract]

Flick MJ, Chauhan AK, Frederick M, Talmage KE, Kombrinck KW, Miller W, Mullins ES, Palumbo JS, Zheng X, Esmon NL, Esmon CT, Thornton S, Becker A, Pelc LA, Di CE, Wagner DD, Degen JL. The development of inflammatory joint disease is attenuated in mice expressing the anticoagulant prothrombin mutant W215A/E217A. Blood 117:6326-6337,2011. [Abstract]

Gavins FN, Russell J, Senchenkova EL, De Almeida PL, Damazo AS, Esmon CT, Kirchhofer D, Hebbel RP, Granger DN. Mechanisms of enhanced thrombus formation in cerebral microvessels of mice expressing hemoglobin-S. Blood 117:4125-4133, 2011. [Abstract]

Huang H, Evankovich J, Yan W, Nace G, Zhang L, Ross M, Liao X, Billiar T, Xu J, Esmon CT, Tsung A. Endogenous histones function as alarmins in sterile inflammatory liver injury through toll-like receptor 9. Hepatology 54:999-1008, 2011. [Abstract]

Schouten M, de Boer JD, van der Sluijs KF, Roelofs JJ, van ‘t Veer C, Levi M, Esmon CT, van der Poll T. Impact of endogenous protein C on pulmonary coagulation and injury during lethal H1N1 influenza in mice. Am J Respir Cell Mol Biol 45:789-794, 2011. [Abstract]

Schouten M, van’t Veer C, Levi M, Esmon CT, van der Poll T. Endogenous protein C inhibits activation of coagulation and transiently lowers bacterial outgrowth in murine Escherichia coli peritonitis. J Thromb Haemost 9:1072-1074, 2011. [Abstract]

Semeraro F, Ammollo CT, Morrissey JH, Dale GL, Friese P, Esmon NL, Esmon CT. Extracellular histones promote thrombin generation through platelet-dependent mechanisms: involvement of platelet TLR2 and TLR4. Blood 118:1952-1961, 2011. [Abstract]

Sen P, Gopalakrishnan R, Kothari H, Keshava S, Clark CA, Esmon CT, Pendurthi UR, Rao LV. Factor VIIa bound to endothelial cell protein C receptor activates protease activated receptor-1 and mediates cell signaling and barrier protection. Blood 117:3199-3208, 2011.  [Abstract]

Sen P, Nayak R, Clark CA, Gopalakrishnan R, Esmon CT, Pendurthi UR, Rao LV. Factor X binding to endothelial cell protein C receptor: comparison with factor VIIa and activated protein C. Blood 118:2635-2636, 2011. [Abstract]

Turpie AG, Esmon C. Venous and arterial thrombosis – pathogenesis and the rationale for anticoagulation. Thromb Haemost 105:586-596,  2011.  [Abstract]

Van Sluis GL, Bruggemann LW, Esmon CT, Kamphuisen PW, Richel DJ, Buller HR, Van Noorden CJ, Spek CA. Endogenous activated protein C is essential for immune-mediated cancer cell elimination from the circulation. Cancer Lett 306:106-110, 2011. [Abstract]

Xu J, Zhang X, Monestier M, Esmon NL, Esmon CT. Extracellular histones are mediators of death through TLR2 and TLR4 in mouse fatal liver injury. J Immunol 187:2626-2631, 2011. [Abstract]

Experimental Therapeutics Research Laboratory

Bhattacharjee S, Deterding LJ, Chatterjee S, Jiang J, Ehrenshaft M, Lardinois O, Ramirez DC, Tomer KB, Mason RP. Site-specific radical formation in DNA induced by Cu(II)-H(2)O(2) oxidizing system, using ESR, immuno-spin trapping, LC-MS, and MS/MS. Free Radic Biol Med 50:1536-1545, 2011. [Abstract]

Choi CH, Chen K, Du X, Floyd RA, Kopke RD. Effects of delayed and extended antioxidant treatment on acute acoustic trauma. Free Radic Res 45:1162-1172, 2011. [Abstract]

Du X, Choi CH, Chen K, Cheng W, Floyd RA, Kopke RD. Reduced formation of oxidative stress biomarkers and migration of mononuclear phagocytes in the cochleae of chinchilla after antioxidant treatment in acute acoustic trauma. Int J Otolaryngol 2011:612690, 2011. [Abstract]

* Floyd RA, Chandru HK, He T, Towner R. Anti-cancer activity of nitrones and observations on mechanism of action. Anticancer Agents Med Chem 11:373-379, 2011. [Abstract]

* Floyd RA, Towner RA, He T, Hensley K, Maples KR. Translational research involving oxidative stress and diseases of aging. Free Radic Biol Med 51:931-941, 2011. [Abstract]

* He T, Doblas S, Saunders D, Casteel R, Lerner M, Ritchey JW, Snider T, Floyd RA, Towner RA. Effects of PBN and OKN007 in rodent glioma models assessed by (1)H MR spectroscopy. Free Radic Biol Med 51:490-502,2011. [Abstract]

Mandal MN, Moiseyev GP, Elliott MH, Kasus-Jacobi A, Li X, Chen H, Zheng L, Nikolaeva O, Floyd RA, Ma JX, Anderson RE. {alpha}-phenyl-N-tert-butyl nitrone (PBN) prevents light-induced degeneration of the retina by inhibiting RPE65 protein isomerohydrolase activity. J Biol Chem 286:32491-32501, 2011. [Abstract]

Free Radical Biology and Aging Research Program

Baily CN, Cason RW, Vadvalkar SS, Matsuzaki S, Humphries KM. Inhibition of mitochondrial respiration by phosphoenolpyruvate. Arch Biochem Biophys 514:68-74, 2011. [Abstract]

Dasuri K, Zhang L, Ebenezer P, Fernandez-Kim SO, Bruce-Keller AJ, Szweda LI, Keller JN. Proteasome alterations during adipose differentiation and aging: links to impaired adipocyte differentiation and development of oxidative stress. Free Radic Biol Med 51:1727-1735, 2011. [Abstract]

Matsuzaki S, Kotake Y, Humphries KM. Identification of mitochondrial electron transport chain-mediated NADH radical formation by EPR spin-trapping techniques. Biochemistry 50:10792-10803, 2011. [Abstract]

McLain AL, Szweda PA, Szweda LI.  alpha-Ketoglutarate dehydrogenase: A mitochondrial redox sensor. Free Radic Res 45:29-36, 2011. [Abstract]

Talbot JJ, Shillingford JM, Vasanth S, Doerr N, Mukherjee S, Kinter MT, Watnick T, Weimbs T. Polycystin-1 regulates STAT activity by a dual mechanism. Proc Natl Acad Sci U S A 108:7985-7990, 2011. [Abstract]

Genetic Models of Disease

Mesa R, Luo S, Hoover CM, Miller K, Minniti A, Inestrosa N, Nonet ML. HID-1, a new component of the peptidergic signaling pathway. Genetics 187:467-483, 2011. [Abstract]

Immunobiology and Cancer Research Program

* Adrianto I, Wen F, Templeton A, Wiley G, King JB, Lessard CJ, Bates JS, Hu Y, Kelly JA, Kaufman KM, Guthridge JM, Alarcón-Riquelme ME, Anaya JM, Bae SC, Bang SY, Boackle SA, Brown EE, Petri MA, Gallant C, Ramsey-Goldman R, Reveille JD, Vila LM, Criswell LA, Edberg JC, Freedman BI, Gregersen PK, Gilkeson GS, Jacob CO, James JA, Kamen DL, Kimberly RP, Martin J, Merrill JT, Niewold TB, Park SY, Pons-Estel BA, Scofield RH, Stevens AM, Tsao BP, Vyse TJ, Langefeld CD, Harley JB, Moser KL, Webb CF, Humphrey MB, Montgomery CG, Gaffney PM. Association of a functional variant downstream of TNFAIP3 with systemic lupus erythematosus. Nat Genet 43:253-258, 2011. [Abstract]

* Air GM, Feng J, Chen T, Joachims ML, James JA, Thompson LF. Individual antibody and T cell responses to vaccination and infection with the 2009 pandemic swine-origin H1N1 influenza virus. J Clin Immunol 31:900-912, 2011. [Abstract]

Cochrane SW, Zhao Y, Perry S, Urbaniak T, Sun XH. Id1 has a physiological role in regulating early B lymphopoiesis. Cell Mol Immunol 8:41-49, 2011. [Abstract]

* Crowe SR, Merrill JT, Vista ES, Dedeke AB, Thompson DM, Stewart S, Guthridge JM, Niewold TB, Franek BS, Air GM, Thompson LF, James JA. Influenza vaccination responses in human systemic lupus erythematosus: impact of clinical and demographic features. Arthritis Rheum 63:2396-2406, 2011. [Abstract]

Esplin BL, Shimazu T, Welner RS, Garrett KP, Nie L, Zhang Q, Humphrey MB, Yang Q, Borghesi LA, Kincade PW. Chronic exposure to a TLR Ligand injures hematopoietic stem cells. J Immunol 186:5367-5375, 2011. [Abstract]

Gimferrer I, Hu T, Simmons A, Wang C, Souabni A, Busslinger M, Bender TP, Hernandez-Hoyos G, Alberola-Ila J. Regulation of GATA-3 Expression during CD4 lineage differentiation. J Immunol 186:3892-3898, 2011. [Abstract]

Haskó G, Csóka B, Koscsó B, Chandra R, Pacher P, Thompson LF, Deitch EA, Spolarics Z, Virág L, Gergely P, Rolandelli RH, Németh ZH. Ecto-5′-Nucleotidase (CD73) decreases mortality and organ injury in sepsis. J Immunol 187:4256-4267, 2011. [Abstract]

Hu T, Gimferrer I, Alberola-Ila J. Control of early stages in invariant natural killer T-cell development. Immunology 134:1-7, 2011. [Abstract]

Hu T, Gimferrer I, Simmons A, Wiest D, Alberola-Ila J. The Ras/MAPK pathway is required for generation of iNKT cells. PLoS One 6:e19890, 2011. [Abstract]

Iyer JK, Coggeshall KM. Primary innate immune cells respond efficiently to polymeric peptidoglycan, but not to peptidoglycan monomers. J Immunol 186:3841-3845, 2011. [Abstract]

Nie L, Zhao Y, Wu W, Yang YZ, Wang HC, Sun XH.  Notch-induced Asb2 expression promotes protein ubiquitination by forming non-canonical E3 ligase complexes. Cell Res 21:754-769, 2011. [Abstract]

Oldham AL, Miner CA, Wang HC, Webb CF. The transcription factor Bright plays a role in marginal zone B lymphocyte development and autoantibody production. Mol Immunol 49:367-379, 2011.[Abstract]

Olson LE, Soriano P. PDGFRbeta signaling regulates mural cell plasticity and inhibits fat development. Dev Cell 20:815-826, 2011. [Abstract]

* Ritterhouse LL, Crowe SR, Niewold TB, Merrill JT, Roberts VC, Dedeke AB, Neas BR, Thompson LF, Guthridge JM, James JA. B lymphocyte stimulator levels in systemic lupus erythematosus: Higher circulating levels in African American patients and increased production after influenza vaccination in patients with low baseline levels. Arthritis Rheum 63:3931-3941, 2011. [Abstract]

Thompson LF, Picher M, Blackburn MR. Animal models of airway diseases. Subcell Biochem 55:195-234, 2011. [Abstract]

Wang L, Fan J, Thompson LF, Zhang Y, Shin T, Curiel TJ, Zhang B. CD73 has distinct roles in nonhematopoietic and hematopoietic cells to promote tumor growth in mice. J Clin Invest 121:2371-2382,2011. [Abstract]

*  Webb CF, Bryant J, Popowski M, Allred L, Kim D, Harriss J, Schmidt C, Miner CA, Rose K, Cheng HL, Griffin C, Tucker PW. The ARID family transcription factor Bright is required for both hematopoietic stem cell and B lineage development. Mol Cell Biol 31:1041-1053, 2011.  [Abstract]

Wu W, Sun XH. A mechanism underlying NOTCH-induced and ubiquitin-mediated JAK3 degradation. J Biol Chem 286:41153-41162, 2011.[Abstract]

Lipid and Lipoprotein Laboratory

Attman PO, Samuelsson O, Alaupovic P. The effect of decreasing renal function on lipoprotein profiles. Nephrol Dial Transplant 26:2572-2575, 2011. [Abstract]

Bagdade J, Pedersen BK, Schwenke D, Saremi A, Alaupovic P. Acute effects of interleukin-6 infusion on apo-B-containing lipoprotein subclasses in humans. Scand J Clin Lab Invest 71:449-455, 2011. [Abstract]

* Lee DM, Jackson KW, Knowlton N, Wages J, Alaupovic P, Samuelsson O, Saeed A, Centola M, Attman PO. Oxidative stress and inflammation in renal patients and healthy subjects. PLoS One 6:e22360, 2011. [Abstract]

Nowakowska FE, Herlitz H, Saeed A, Attman PO, Jensen G, Alaupovic P, Guron G. Lipoprotein abnormalities in patients with atherosclerotic renovascular disease. Kidney Blood Press Res 34:311-319, 2011. [Abstract]

Protein Studies Research Program

Chang WP, Huang X, Downs D, Cirrito JR, Koelsch G, Holtzman DM, Ghosh AK, Tang J. {beta}-Secretase inhibitor GRL-8234 rescues age-related cognitive decline in APP transgenic mice. FASEB J 25:775-784, 2011. [Abstract]

Li F, Terzyan S, Tang J. Subsite specificity of anthrax lethal factor and its implications for inhibitor development. Biochem Biophys Res Commun 407:400-405, 2011. [Abstract]

Tang J, Ghosh A. Treating transgenic Alzheimer mice with a beta-secretase inhibitor, what have we learned? Aging (Albany NY) 3:14-16, 2011. [Abstract]

 

* Indicates publications by more than one department.

 

Additional Publications:
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